-- dump date 20140619_093730 -- class Genbank::misc_feature -- table misc_feature_note -- id note 313603000001 Family description; Region: VCBS; pfam13517 313603000002 Family description; Region: VCBS; pfam13517 313603000003 Family description; Region: VCBS; pfam13517 313603000004 Family description; Region: VCBS; pfam13517 313603000005 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 313603000006 Immunoglobulin domain; Region: Ig_3; pfam13927 313603000007 Calx-beta domain; Region: Calx-beta; pfam03160 313603000008 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 313603000009 Right handed beta helix region; Region: Beta_helix; pfam13229 313603000010 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603000011 binding surface 313603000012 TPR motif; other site 313603000013 Tetratricopeptide repeat; Region: TPR_16; pfam13432 313603000014 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 313603000015 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 313603000016 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 313603000017 ligand binding site [chemical binding]; other site 313603000018 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 313603000019 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 313603000020 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 313603000021 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 313603000022 G1 box; other site 313603000023 putative GEF interaction site [polypeptide binding]; other site 313603000024 GTP/Mg2+ binding site [chemical binding]; other site 313603000025 Switch I region; other site 313603000026 G2 box; other site 313603000027 G3 box; other site 313603000028 Switch II region; other site 313603000029 G4 box; other site 313603000030 G5 box; other site 313603000031 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 313603000032 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 313603000033 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 313603000034 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 313603000035 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 313603000036 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 313603000037 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 313603000038 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 313603000039 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 313603000040 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 313603000041 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 313603000042 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 313603000043 DNA binding site [nucleotide binding] 313603000044 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 313603000045 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 313603000046 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 313603000047 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 313603000048 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 313603000049 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 313603000050 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 313603000051 RPB3 interaction site [polypeptide binding]; other site 313603000052 RPB1 interaction site [polypeptide binding]; other site 313603000053 RPB11 interaction site [polypeptide binding]; other site 313603000054 RPB10 interaction site [polypeptide binding]; other site 313603000055 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 313603000056 core dimer interface [polypeptide binding]; other site 313603000057 peripheral dimer interface [polypeptide binding]; other site 313603000058 L10 interface [polypeptide binding]; other site 313603000059 L11 interface [polypeptide binding]; other site 313603000060 putative EF-Tu interaction site [polypeptide binding]; other site 313603000061 putative EF-G interaction site [polypeptide binding]; other site 313603000062 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 313603000063 23S rRNA interface [nucleotide binding]; other site 313603000064 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 313603000065 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 313603000066 mRNA/rRNA interface [nucleotide binding]; other site 313603000067 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 313603000068 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 313603000069 23S rRNA interface [nucleotide binding]; other site 313603000070 L7/L12 interface [polypeptide binding]; other site 313603000071 putative thiostrepton binding site; other site 313603000072 L25 interface [polypeptide binding]; other site 313603000073 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 313603000074 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 313603000075 putative homodimer interface [polypeptide binding]; other site 313603000076 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 313603000077 heterodimer interface [polypeptide binding]; other site 313603000078 homodimer interface [polypeptide binding]; other site 313603000079 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 313603000080 elongation factor Tu; Reviewed; Region: PRK12735 313603000081 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 313603000082 G1 box; other site 313603000083 GEF interaction site [polypeptide binding]; other site 313603000084 GTP/Mg2+ binding site [chemical binding]; other site 313603000085 Switch I region; other site 313603000086 G2 box; other site 313603000087 G3 box; other site 313603000088 Switch II region; other site 313603000089 G4 box; other site 313603000090 G5 box; other site 313603000091 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 313603000092 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 313603000093 Antibiotic Binding Site [chemical binding]; other site 313603000094 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 313603000095 30S subunit binding site; other site 313603000096 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 313603000097 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 313603000098 active site 313603000099 DNA binding site [nucleotide binding] 313603000100 Int/Topo IB signature motif; other site 313603000101 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 313603000102 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 313603000103 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 313603000104 active site 313603000105 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 313603000106 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 313603000107 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 313603000108 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 313603000109 Ion channel; Region: Ion_trans_2; pfam07885 313603000110 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 313603000111 TrkA-N domain; Region: TrkA_N; pfam02254 313603000112 TrkA-C domain; Region: TrkA_C; pfam02080 313603000113 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 313603000114 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603000115 active site residue [active] 313603000116 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 313603000117 MarR family; Region: MarR; pfam01047 313603000118 YceI-like domain; Region: YceI; smart00867 313603000119 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 313603000120 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 313603000121 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 313603000122 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 313603000123 Glutamine amidotransferase class-I; Region: GATase; pfam00117 313603000124 glutamine binding [chemical binding]; other site 313603000125 catalytic triad [active] 313603000126 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 313603000127 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 313603000128 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 313603000129 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 313603000130 active site 313603000131 ribulose/triose binding site [chemical binding]; other site 313603000132 phosphate binding site [ion binding]; other site 313603000133 substrate (anthranilate) binding pocket [chemical binding]; other site 313603000134 product (indole) binding pocket [chemical binding]; other site 313603000135 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 313603000136 active site 313603000137 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 313603000138 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 313603000139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603000140 catalytic residue [active] 313603000141 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 313603000142 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 313603000143 substrate binding site [chemical binding]; other site 313603000144 active site 313603000145 catalytic residues [active] 313603000146 heterodimer interface [polypeptide binding]; other site 313603000147 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_1; cd05678 313603000148 hypothetical protein; Provisional; Region: PRK08201 313603000149 putative metal binding site [ion binding]; other site 313603000150 putative dimer interface [polypeptide binding]; other site 313603000151 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 313603000152 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 313603000153 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 313603000154 putative active site [active] 313603000155 hypothetical protein; Validated; Region: PRK02101 313603000156 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 313603000157 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 313603000158 RNA binding surface [nucleotide binding]; other site 313603000159 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 313603000160 active site 313603000161 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 313603000162 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 313603000163 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 313603000164 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 313603000165 ATP-grasp domain; Region: ATP-grasp_4; cl17255 313603000166 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 313603000167 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 313603000168 active site 313603000169 (T/H)XGH motif; other site 313603000170 PAS fold; Region: PAS_4; pfam08448 313603000171 PAS domain; Region: PAS_9; pfam13426 313603000172 PAS fold; Region: PAS_4; pfam08448 313603000173 PAS fold; Region: PAS_4; pfam08448 313603000174 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 313603000175 putative active site [active] 313603000176 heme pocket [chemical binding]; other site 313603000177 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 313603000178 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 313603000179 putative active site [active] 313603000180 heme pocket [chemical binding]; other site 313603000181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 313603000182 putative active site [active] 313603000183 heme pocket [chemical binding]; other site 313603000184 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 313603000185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603000186 ATP binding site [chemical binding]; other site 313603000187 Mg2+ binding site [ion binding]; other site 313603000188 G-X-G motif; other site 313603000189 Response regulator receiver domain; Region: Response_reg; pfam00072 313603000190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603000191 active site 313603000192 phosphorylation site [posttranslational modification] 313603000193 intermolecular recognition site; other site 313603000194 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 313603000195 nudix motif; other site 313603000196 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 313603000197 active site 313603000198 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 313603000199 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 313603000200 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 313603000201 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 313603000202 FtsH Extracellular; Region: FtsH_ext; pfam06480 313603000203 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 313603000204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603000205 Walker A motif; other site 313603000206 ATP binding site [chemical binding]; other site 313603000207 Walker B motif; other site 313603000208 arginine finger; other site 313603000209 Peptidase family M41; Region: Peptidase_M41; pfam01434 313603000210 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 313603000211 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 313603000212 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 313603000213 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 313603000214 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 313603000215 Creatinine amidohydrolase; Region: Creatininase; pfam02633 313603000216 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 313603000217 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 313603000218 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 313603000219 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 313603000220 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 313603000221 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 313603000222 active site 313603000223 HIGH motif; other site 313603000224 nucleotide binding site [chemical binding]; other site 313603000225 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 313603000226 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 313603000227 active site 313603000228 KMSKS motif; other site 313603000229 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 313603000230 tRNA binding surface [nucleotide binding]; other site 313603000231 anticodon binding site; other site 313603000232 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 313603000233 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 313603000234 Aspartyl protease; Region: Asp_protease_2; pfam13650 313603000235 Aspartyl protease; Region: Asp_protease_2; pfam13650 313603000236 inhibitor binding site; inhibition site 313603000237 catalytic motif [active] 313603000238 Catalytic residue [active] 313603000239 Active site flap [active] 313603000240 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 313603000241 aspartate aminotransferase; Provisional; Region: PRK07568 313603000242 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 313603000243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603000244 homodimer interface [polypeptide binding]; other site 313603000245 catalytic residue [active] 313603000246 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 313603000247 FAD binding domain; Region: FAD_binding_4; pfam01565 313603000248 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 313603000249 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 313603000250 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603000251 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603000252 DNA binding residues [nucleotide binding] 313603000253 Anti-sigma-K factor rskA; Region: RskA; pfam10099 313603000254 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 313603000255 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603000256 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603000257 DNA binding residues [nucleotide binding] 313603000258 lipoyl synthase; Provisional; Region: PRK05481 313603000259 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 313603000260 FeS/SAM binding site; other site 313603000261 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 313603000262 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 313603000263 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 313603000264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 313603000265 binding surface 313603000266 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603000267 TPR motif; other site 313603000268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 313603000269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 313603000270 dimer interface [polypeptide binding]; other site 313603000271 phosphorylation site [posttranslational modification] 313603000272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603000273 ATP binding site [chemical binding]; other site 313603000274 Mg2+ binding site [ion binding]; other site 313603000275 G-X-G motif; other site 313603000276 Response regulator receiver domain; Region: Response_reg; pfam00072 313603000277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603000278 active site 313603000279 phosphorylation site [posttranslational modification] 313603000280 intermolecular recognition site; other site 313603000281 dimerization interface [polypeptide binding]; other site 313603000282 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 313603000283 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 313603000284 Uncharacterized conserved protein [Function unknown]; Region: COG0327 313603000285 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 313603000286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 313603000287 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 313603000288 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 313603000289 Putative zinc ribbon domain; Region: DUF164; pfam02591 313603000290 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 313603000291 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 313603000292 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 313603000293 Clp protease; Region: CLP_protease; pfam00574 313603000294 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 313603000295 oligomer interface [polypeptide binding]; other site 313603000296 active site residues [active] 313603000297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603000298 putative substrate translocation pore; other site 313603000299 Cupin domain; Region: Cupin_2; pfam07883 313603000300 Helix-turn-helix domain; Region: HTH_18; pfam12833 313603000301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603000302 kynureninase; Region: kynureninase; TIGR01814 313603000303 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 313603000304 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 313603000305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603000306 Coenzyme A binding pocket [chemical binding]; other site 313603000307 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 313603000308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603000309 S-adenosylmethionine binding site [chemical binding]; other site 313603000310 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 313603000311 active site 313603000312 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 313603000313 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 313603000314 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 313603000315 Zn binding site [ion binding]; other site 313603000316 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603000317 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603000318 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603000319 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 313603000320 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 313603000321 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 313603000322 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 313603000323 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 313603000324 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 313603000325 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 313603000326 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 313603000327 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 313603000328 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 313603000329 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 313603000330 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 313603000331 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 313603000332 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 313603000333 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 313603000334 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 313603000335 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 313603000336 Peptidase family M48; Region: Peptidase_M48; pfam01435 313603000337 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 313603000338 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 313603000339 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 313603000340 phosphoglyceromutase; Provisional; Region: PRK05434 313603000341 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 313603000342 active site 313603000343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603000344 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 313603000345 ApbE family; Region: ApbE; pfam02424 313603000346 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 313603000347 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 313603000348 catalytic loop [active] 313603000349 iron binding site [ion binding]; other site 313603000350 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 313603000351 FAD binding pocket [chemical binding]; other site 313603000352 FAD binding motif [chemical binding]; other site 313603000353 phosphate binding motif [ion binding]; other site 313603000354 beta-alpha-beta structure motif; other site 313603000355 NAD binding pocket [chemical binding]; other site 313603000356 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 313603000357 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 313603000358 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 313603000359 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 313603000360 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 313603000361 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 313603000362 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 313603000363 Double zinc ribbon; Region: DZR; pfam12773 313603000364 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 313603000365 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 313603000366 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 313603000367 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 313603000368 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 313603000369 Glutamate binding site [chemical binding]; other site 313603000370 NAD binding site [chemical binding]; other site 313603000371 catalytic residues [active] 313603000372 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 313603000373 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 313603000374 Fatty acid desaturase; Region: FA_desaturase; pfam00487 313603000375 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 313603000376 putative di-iron ligands [ion binding]; other site 313603000377 aspartate aminotransferase; Provisional; Region: PRK05764 313603000378 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 313603000379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603000380 homodimer interface [polypeptide binding]; other site 313603000381 catalytic residue [active] 313603000382 Cation transport protein; Region: TrkH; cl17365 313603000383 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 313603000384 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 313603000385 TrkA-N domain; Region: TrkA_N; pfam02254 313603000386 TrkA-C domain; Region: TrkA_C; pfam02080 313603000387 TrkA-N domain; Region: TrkA_N; pfam02254 313603000388 TrkA-C domain; Region: TrkA_C; pfam02080 313603000389 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 313603000390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603000391 S-adenosylmethionine binding site [chemical binding]; other site 313603000392 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 313603000393 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 313603000394 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 313603000395 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 313603000396 Surface antigen; Region: Bac_surface_Ag; pfam01103 313603000397 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 313603000398 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 313603000399 active site 313603000400 intersubunit interface [polypeptide binding]; other site 313603000401 zinc binding site [ion binding]; other site 313603000402 Na+ binding site [ion binding]; other site 313603000403 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 313603000404 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 313603000405 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 313603000406 16S/18S rRNA binding site [nucleotide binding]; other site 313603000407 S13e-L30e interaction site [polypeptide binding]; other site 313603000408 25S rRNA binding site [nucleotide binding]; other site 313603000409 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 313603000410 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 313603000411 RNase E interface [polypeptide binding]; other site 313603000412 trimer interface [polypeptide binding]; other site 313603000413 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 313603000414 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 313603000415 RNase E interface [polypeptide binding]; other site 313603000416 trimer interface [polypeptide binding]; other site 313603000417 active site 313603000418 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 313603000419 putative nucleic acid binding region [nucleotide binding]; other site 313603000420 G-X-X-G motif; other site 313603000421 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 313603000422 RNA binding site [nucleotide binding]; other site 313603000423 domain interface; other site 313603000424 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 313603000425 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 313603000426 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603000427 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 313603000428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603000429 DNA binding residues [nucleotide binding] 313603000430 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 313603000431 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 313603000432 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 313603000433 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 313603000434 DNA interaction; other site 313603000435 Metal-binding active site; metal-binding site 313603000436 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 313603000437 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 313603000438 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603000439 binding surface 313603000440 TPR repeat; Region: TPR_11; pfam13414 313603000441 TPR motif; other site 313603000442 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603000443 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 313603000444 active site 313603000445 catalytic triad [active] 313603000446 oxyanion hole [active] 313603000447 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 313603000448 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 313603000449 substrate binding site [chemical binding]; other site 313603000450 hexamer interface [polypeptide binding]; other site 313603000451 metal binding site [ion binding]; metal-binding site 313603000452 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 313603000453 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 313603000454 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 313603000455 Cupin domain; Region: Cupin_2; pfam07883 313603000456 Helix-turn-helix domain; Region: HTH_18; pfam12833 313603000457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603000458 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 313603000459 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 313603000460 Trehalose utilisation; Region: ThuA; pfam06283 313603000461 Cupin domain; Region: Cupin_2; pfam07883 313603000462 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 313603000463 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 313603000464 hypothetical protein; Provisional; Region: PRK02399 313603000465 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 313603000466 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 313603000467 Yqey-like protein; Region: YqeY; pfam09424 313603000468 cell division protein FtsZ; Validated; Region: PRK09330 313603000469 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 313603000470 nucleotide binding site [chemical binding]; other site 313603000471 SulA interaction site; other site 313603000472 cell division protein FtsA; Region: ftsA; TIGR01174 313603000473 Cell division protein FtsA; Region: FtsA; smart00842 313603000474 Cell division protein FtsA; Region: FtsA; pfam14450 313603000475 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 313603000476 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 313603000477 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 313603000478 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 313603000479 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 313603000480 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 313603000481 active site 313603000482 homodimer interface [polypeptide binding]; other site 313603000483 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 313603000484 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 313603000485 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 313603000486 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 313603000487 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 313603000488 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 313603000489 Mg++ binding site [ion binding]; other site 313603000490 putative catalytic motif [active] 313603000491 putative substrate binding site [chemical binding]; other site 313603000492 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 313603000493 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 313603000494 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 313603000495 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 313603000496 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 313603000497 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 313603000498 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 313603000499 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 313603000500 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 313603000501 MraW methylase family; Region: Methyltransf_5; cl17771 313603000502 MraZ protein; Region: MraZ; pfam02381 313603000503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 313603000504 MraZ protein; Region: MraZ; pfam02381 313603000505 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 313603000506 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 313603000507 G1 box; other site 313603000508 GTP/Mg2+ binding site [chemical binding]; other site 313603000509 Switch I region; other site 313603000510 G2 box; other site 313603000511 G3 box; other site 313603000512 Switch II region; other site 313603000513 G4 box; other site 313603000514 G5 box; other site 313603000515 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 313603000516 active site 313603000517 metal binding site [ion binding]; metal-binding site 313603000518 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 313603000519 6-phosphofructokinase; Region: PLN02884 313603000520 active site 313603000521 ADP/pyrophosphate binding site [chemical binding]; other site 313603000522 dimerization interface [polypeptide binding]; other site 313603000523 allosteric effector site; other site 313603000524 fructose-1,6-bisphosphate binding site; other site 313603000525 gliding motility-associated protein GldC; Region: GldC; TIGR03515 313603000526 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 313603000527 NAD synthetase; Provisional; Region: PRK13980 313603000528 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 313603000529 homodimer interface [polypeptide binding]; other site 313603000530 NAD binding pocket [chemical binding]; other site 313603000531 ATP binding pocket [chemical binding]; other site 313603000532 Mg binding site [ion binding]; other site 313603000533 active-site loop [active] 313603000534 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 313603000535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603000536 active site 313603000537 phosphorylation site [posttranslational modification] 313603000538 intermolecular recognition site; other site 313603000539 dimerization interface [polypeptide binding]; other site 313603000540 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 313603000541 DNA binding residues [nucleotide binding] 313603000542 dimerization interface [polypeptide binding]; other site 313603000543 DNA primase, catalytic core; Region: dnaG; TIGR01391 313603000544 CHC2 zinc finger; Region: zf-CHC2; cl17510 313603000545 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 313603000546 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 313603000547 active site 313603000548 metal binding site [ion binding]; metal-binding site 313603000549 interdomain interaction site; other site 313603000550 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 313603000551 thymidine kinase; Provisional; Region: PRK04296 313603000552 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 313603000553 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 313603000554 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603000555 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603000556 DNA binding residues [nucleotide binding] 313603000557 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 313603000558 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 313603000559 substrate binding pocket [chemical binding]; other site 313603000560 chain length determination region; other site 313603000561 substrate-Mg2+ binding site; other site 313603000562 catalytic residues [active] 313603000563 aspartate-rich region 1; other site 313603000564 active site lid residues [active] 313603000565 aspartate-rich region 2; other site 313603000566 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 313603000567 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 313603000568 FeS/SAM binding site; other site 313603000569 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 313603000570 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 313603000571 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 313603000572 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 313603000573 hinge; other site 313603000574 active site 313603000575 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 313603000576 homodimer interface [polypeptide binding]; other site 313603000577 metal binding site [ion binding]; metal-binding site 313603000578 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 313603000579 putative active site [active] 313603000580 dimerization interface [polypeptide binding]; other site 313603000581 putative tRNAtyr binding site [nucleotide binding]; other site 313603000582 GTPase RsgA; Reviewed; Region: PRK00098 313603000583 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 313603000584 RNA binding site [nucleotide binding]; other site 313603000585 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 313603000586 GTPase/Zn-binding domain interface [polypeptide binding]; other site 313603000587 GTP/Mg2+ binding site [chemical binding]; other site 313603000588 G4 box; other site 313603000589 G5 box; other site 313603000590 G1 box; other site 313603000591 Switch I region; other site 313603000592 G2 box; other site 313603000593 G3 box; other site 313603000594 Switch II region; other site 313603000595 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 313603000596 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 313603000597 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 313603000598 Chorismate mutase type II; Region: CM_2; smart00830 313603000599 prephenate dehydrogenase; Validated; Region: PRK08507 313603000600 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 313603000601 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 313603000602 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 313603000603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603000604 homodimer interface [polypeptide binding]; other site 313603000605 catalytic residue [active] 313603000606 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 313603000607 Prephenate dehydratase; Region: PDT; pfam00800 313603000608 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 313603000609 putative L-Phe binding site [chemical binding]; other site 313603000610 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603000611 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603000612 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 313603000613 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 313603000614 FAD binding site [chemical binding]; other site 313603000615 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 313603000616 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 313603000617 substrate binding pocket [chemical binding]; other site 313603000618 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 313603000619 B12 binding site [chemical binding]; other site 313603000620 cobalt ligand [ion binding]; other site 313603000621 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 313603000622 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 313603000623 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 313603000624 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 313603000625 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 313603000626 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 313603000627 active site 313603000628 SAM binding site [chemical binding]; other site 313603000629 homodimer interface [polypeptide binding]; other site 313603000630 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 313603000631 precorrin-3B synthase; Region: CobG; TIGR02435 313603000632 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 313603000633 HEPN domain; Region: HEPN; cl00824 313603000634 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 313603000635 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 313603000636 CysD dimerization site [polypeptide binding]; other site 313603000637 G1 box; other site 313603000638 putative GEF interaction site [polypeptide binding]; other site 313603000639 GTP/Mg2+ binding site [chemical binding]; other site 313603000640 Switch I region; other site 313603000641 G2 box; other site 313603000642 G3 box; other site 313603000643 Switch II region; other site 313603000644 G4 box; other site 313603000645 G5 box; other site 313603000646 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 313603000647 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 313603000648 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 313603000649 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 313603000650 Active Sites [active] 313603000651 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 313603000652 Active Sites [active] 313603000653 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 313603000654 Rrf2 family protein; Region: rrf2_super; TIGR00738 313603000655 Transcriptional regulator; Region: Rrf2; pfam02082 313603000656 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 313603000657 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 313603000658 homodimer interface [polypeptide binding]; other site 313603000659 substrate-cofactor binding pocket; other site 313603000660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603000661 catalytic residue [active] 313603000662 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 313603000663 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 313603000664 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 313603000665 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 313603000666 putative catalytic residues [active] 313603000667 putative nucleotide binding site [chemical binding]; other site 313603000668 putative aspartate binding site [chemical binding]; other site 313603000669 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 313603000670 dimer interface [polypeptide binding]; other site 313603000671 putative threonine allosteric regulatory site; other site 313603000672 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 313603000673 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 313603000674 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 313603000675 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 313603000676 homodimer interface [polypeptide binding]; other site 313603000677 substrate-cofactor binding pocket; other site 313603000678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603000679 catalytic residue [active] 313603000680 S-adenosylmethionine synthetase; Validated; Region: PRK05250 313603000681 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 313603000682 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 313603000683 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 313603000684 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 313603000685 GLPGLI family protein; Region: GLPGLI; TIGR01200 313603000686 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 313603000687 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 313603000688 Substrate-binding site [chemical binding]; other site 313603000689 Substrate specificity [chemical binding]; other site 313603000690 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 313603000691 active site pocket [active] 313603000692 oxyanion hole [active] 313603000693 catalytic triad [active] 313603000694 active site nucleophile [active] 313603000695 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 313603000696 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 313603000697 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 313603000698 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 313603000699 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 313603000700 dimer interface [polypeptide binding]; other site 313603000701 substrate binding site [chemical binding]; other site 313603000702 metal binding sites [ion binding]; metal-binding site 313603000703 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603000704 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 313603000705 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 313603000706 alpha subunit interface [polypeptide binding]; other site 313603000707 TPP binding site [chemical binding]; other site 313603000708 heterodimer interface [polypeptide binding]; other site 313603000709 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 313603000710 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 313603000711 Ligand binding site [chemical binding]; other site 313603000712 Electron transfer flavoprotein domain; Region: ETF; pfam01012 313603000713 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 313603000714 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 313603000715 Ligand Binding Site [chemical binding]; other site 313603000716 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 313603000717 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 313603000718 Bifunctional nuclease; Region: DNase-RNase; pfam02577 313603000719 UvrB/uvrC motif; Region: UVR; pfam02151 313603000720 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 313603000721 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 313603000722 Nucleoside recognition; Region: Gate; pfam07670 313603000723 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 313603000724 thymidylate synthase; Reviewed; Region: thyA; PRK01827 313603000725 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 313603000726 dimerization interface [polypeptide binding]; other site 313603000727 active site 313603000728 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 313603000729 2TM domain; Region: 2TM; pfam13239 313603000730 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 313603000731 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 313603000732 folate binding site [chemical binding]; other site 313603000733 NADP+ binding site [chemical binding]; other site 313603000734 glutamate racemase; Provisional; Region: PRK00865 313603000735 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 313603000736 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 313603000737 Permease; Region: Permease; pfam02405 313603000738 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 313603000739 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 313603000740 Walker A/P-loop; other site 313603000741 ATP binding site [chemical binding]; other site 313603000742 Q-loop/lid; other site 313603000743 ABC transporter signature motif; other site 313603000744 Walker B; other site 313603000745 D-loop; other site 313603000746 H-loop/switch region; other site 313603000747 Domain of unknown function (DUF389); Region: DUF389; pfam04087 313603000748 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 313603000749 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 313603000750 Substrate binding site; other site 313603000751 SprT homologues; Region: SprT; cl01182 313603000752 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 313603000753 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 313603000754 substrate binding pocket [chemical binding]; other site 313603000755 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 313603000756 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 313603000757 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 313603000758 active site 313603000759 classical (c) SDRs; Region: SDR_c; cd05233 313603000760 short chain dehydrogenase; Provisional; Region: PRK12747 313603000761 NAD(P) binding site [chemical binding]; other site 313603000762 active site 313603000763 M28 Zn-Peptidase IAP aminopeptidase may contain PA domain insert; Region: M28_like_5; cd08021 313603000764 Peptidase family M28; Region: Peptidase_M28; pfam04389 313603000765 metal binding site [ion binding]; metal-binding site 313603000766 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 313603000767 E3 interaction surface; other site 313603000768 lipoyl attachment site [posttranslational modification]; other site 313603000769 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 313603000770 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 313603000771 E3 interaction surface; other site 313603000772 lipoyl attachment site [posttranslational modification]; other site 313603000773 e3 binding domain; Region: E3_binding; pfam02817 313603000774 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 313603000775 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 313603000776 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 313603000777 tetramer interface [polypeptide binding]; other site 313603000778 TPP-binding site [chemical binding]; other site 313603000779 heterodimer interface [polypeptide binding]; other site 313603000780 phosphorylation loop region [posttranslational modification] 313603000781 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 313603000782 active site 313603000783 catalytic motif [active] 313603000784 Zn binding site [ion binding]; other site 313603000785 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 313603000786 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 313603000787 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 313603000788 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 313603000789 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 313603000790 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 313603000791 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 313603000792 phosphate binding site [ion binding]; other site 313603000793 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 313603000794 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 313603000795 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 313603000796 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 313603000797 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 313603000798 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 313603000799 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 313603000800 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 313603000801 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 313603000802 NAD(P) binding pocket [chemical binding]; other site 313603000803 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 313603000804 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 313603000805 active site 313603000806 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 313603000807 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 313603000808 active site 313603000809 dimer interface [polypeptide binding]; other site 313603000810 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 313603000811 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 313603000812 active site 313603000813 FMN binding site [chemical binding]; other site 313603000814 substrate binding site [chemical binding]; other site 313603000815 3Fe-4S cluster binding site [ion binding]; other site 313603000816 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 313603000817 domain interface; other site 313603000818 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 313603000819 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 313603000820 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 313603000821 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 313603000822 nucleotide binding site [chemical binding]; other site 313603000823 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 313603000824 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 313603000825 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 313603000826 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 313603000827 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 313603000828 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 313603000829 active site 313603000830 dimer interface [polypeptide binding]; other site 313603000831 motif 1; other site 313603000832 motif 2; other site 313603000833 motif 3; other site 313603000834 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 313603000835 anticodon binding site; other site 313603000836 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 313603000837 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 313603000838 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 313603000839 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 313603000840 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 313603000841 23S rRNA binding site [nucleotide binding]; other site 313603000842 L21 binding site [polypeptide binding]; other site 313603000843 L13 binding site [polypeptide binding]; other site 313603000844 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 313603000845 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 313603000846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 313603000847 active site 313603000848 motif I; other site 313603000849 motif II; other site 313603000850 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 313603000851 replicative DNA helicase; Region: DnaB; TIGR00665 313603000852 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 313603000853 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 313603000854 Walker A motif; other site 313603000855 ATP binding site [chemical binding]; other site 313603000856 Walker B motif; other site 313603000857 DNA binding loops [nucleotide binding] 313603000858 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 313603000859 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 313603000860 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 313603000861 Predicted permeases [General function prediction only]; Region: COG0795 313603000862 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 313603000863 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 313603000864 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 313603000865 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 313603000866 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 313603000867 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 313603000868 RNA binding surface [nucleotide binding]; other site 313603000869 MG2 domain; Region: A2M_N; pfam01835 313603000870 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 313603000871 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 313603000872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 313603000873 active site 313603000874 Shikimate kinase; Region: SKI; pfam01202 313603000875 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 313603000876 ADP binding site [chemical binding]; other site 313603000877 magnesium binding site [ion binding]; other site 313603000878 putative shikimate binding site; other site 313603000879 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 313603000880 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 313603000881 Na binding site [ion binding]; other site 313603000882 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 313603000883 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 313603000884 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 313603000885 active site 313603000886 dimer interface [polypeptide binding]; other site 313603000887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 313603000888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 313603000889 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 313603000890 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 313603000891 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 313603000892 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 313603000893 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 313603000894 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 313603000895 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 313603000896 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603000897 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603000898 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 313603000899 nucleoside/Zn binding site; other site 313603000900 dimer interface [polypeptide binding]; other site 313603000901 catalytic motif [active] 313603000902 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 313603000903 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603000904 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603000905 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 313603000906 classical (c) SDRs; Region: SDR_c; cd05233 313603000907 NAD(P) binding site [chemical binding]; other site 313603000908 active site 313603000909 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 313603000910 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 313603000911 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 313603000912 Pirin-related protein [General function prediction only]; Region: COG1741 313603000913 Pirin; Region: Pirin; pfam02678 313603000914 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 313603000915 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 313603000916 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 313603000917 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 313603000918 FMN binding site [chemical binding]; other site 313603000919 active site 313603000920 substrate binding site [chemical binding]; other site 313603000921 catalytic residue [active] 313603000922 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603000923 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603000924 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 313603000925 homotrimer interaction site [polypeptide binding]; other site 313603000926 putative active site [active] 313603000927 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 313603000928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603000929 NAD(P) binding site [chemical binding]; other site 313603000930 active site 313603000931 haloalkane dehalogenase; Provisional; Region: PRK03204 313603000932 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 313603000933 MarR family; Region: MarR_2; pfam12802 313603000934 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 313603000935 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 313603000936 ligand binding site [chemical binding]; other site 313603000937 flexible hinge region; other site 313603000938 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 313603000939 Putative esterase; Region: Esterase; pfam00756 313603000940 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 313603000941 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 313603000942 active site 313603000943 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 313603000944 dimer interface [polypeptide binding]; other site 313603000945 FMN binding site [chemical binding]; other site 313603000946 Protein of unknown function, DUF606; Region: DUF606; pfam04657 313603000947 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603000948 Coenzyme A binding pocket [chemical binding]; other site 313603000949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 313603000950 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 313603000951 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 313603000952 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 313603000953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603000954 NADH(P)-binding; Region: NAD_binding_10; pfam13460 313603000955 NAD(P) binding site [chemical binding]; other site 313603000956 active site 313603000957 Uncharacterized conserved protein [Function unknown]; Region: COG2128 313603000958 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 313603000959 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 313603000960 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 313603000961 putative substrate binding pocket [chemical binding]; other site 313603000962 trimer interface [polypeptide binding]; other site 313603000963 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 313603000964 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603000965 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603000966 TPR repeat; Region: TPR_11; pfam13414 313603000967 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 313603000968 Active site serine [active] 313603000969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603000970 Coenzyme A binding pocket [chemical binding]; other site 313603000971 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 313603000972 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 313603000973 putative dimer interface [polypeptide binding]; other site 313603000974 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 313603000975 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 313603000976 nucleophile elbow; other site 313603000977 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 313603000978 propionate/acetate kinase; Provisional; Region: PRK12379 313603000979 phosphate acetyltransferase; Reviewed; Region: PRK05632 313603000980 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 313603000981 DRTGG domain; Region: DRTGG; pfam07085 313603000982 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 313603000983 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603000984 Ligand Binding Site [chemical binding]; other site 313603000985 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603000986 Ligand Binding Site [chemical binding]; other site 313603000987 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603000988 Ligand Binding Site [chemical binding]; other site 313603000989 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603000990 Ligand Binding Site [chemical binding]; other site 313603000991 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 313603000992 intersubunit interface [polypeptide binding]; other site 313603000993 active site 313603000994 catalytic residue [active] 313603000995 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 313603000996 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 313603000997 KWG Leptospira; Region: KWG; pfam07656 313603000998 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 313603000999 classical (c) SDRs; Region: SDR_c; cd05233 313603001000 NAD(P) binding site [chemical binding]; other site 313603001001 active site 313603001002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603001003 Coenzyme A binding pocket [chemical binding]; other site 313603001004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 313603001005 YoaP-like; Region: YoaP; pfam14268 313603001006 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 313603001007 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 313603001008 aspartokinase; Region: PLN02551 313603001009 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 313603001010 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 313603001011 metal binding site [ion binding]; metal-binding site 313603001012 dimer interface [polypeptide binding]; other site 313603001013 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 313603001014 Domain of unknown function DUF302; Region: DUF302; cl01364 313603001015 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 313603001016 mce related protein; Region: MCE; pfam02470 313603001017 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 313603001018 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 313603001019 Walker A/P-loop; other site 313603001020 ATP binding site [chemical binding]; other site 313603001021 Q-loop/lid; other site 313603001022 ABC transporter signature motif; other site 313603001023 Walker B; other site 313603001024 D-loop; other site 313603001025 H-loop/switch region; other site 313603001026 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 313603001027 Permease; Region: Permease; pfam02405 313603001028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 313603001029 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 313603001030 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 313603001031 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 313603001032 catalytic residues [active] 313603001033 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 313603001034 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 313603001035 catalytic residues [active] 313603001036 aconitate hydratase; Validated; Region: PRK07229 313603001037 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 313603001038 substrate binding site [chemical binding]; other site 313603001039 ligand binding site [chemical binding]; other site 313603001040 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 313603001041 substrate binding site [chemical binding]; other site 313603001042 MoxR-like ATPases [General function prediction only]; Region: COG0714 313603001043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603001044 Walker A motif; other site 313603001045 ATP binding site [chemical binding]; other site 313603001046 Walker B motif; other site 313603001047 arginine finger; other site 313603001048 SurA N-terminal domain; Region: SurA_N; pfam09312 313603001049 PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions; Region: PET; cl05674 313603001050 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 313603001051 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 313603001052 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 313603001053 hydrophobic ligand binding site; other site 313603001054 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 313603001055 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 313603001056 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 313603001057 RNA binding surface [nucleotide binding]; other site 313603001058 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 313603001059 probable active site [active] 313603001060 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603001061 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 313603001062 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 313603001063 ATP binding site [chemical binding]; other site 313603001064 putative Mg++ binding site [ion binding]; other site 313603001065 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 313603001066 nucleotide binding region [chemical binding]; other site 313603001067 ATP-binding site [chemical binding]; other site 313603001068 RQC domain; Region: RQC; pfam09382 313603001069 HRDC domain; Region: HRDC; pfam00570 313603001070 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 313603001071 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 313603001072 putative active site [active] 313603001073 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 313603001074 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 313603001075 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 313603001076 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 313603001077 Walker A/P-loop; other site 313603001078 ATP binding site [chemical binding]; other site 313603001079 Q-loop/lid; other site 313603001080 ABC transporter signature motif; other site 313603001081 Walker B; other site 313603001082 D-loop; other site 313603001083 H-loop/switch region; other site 313603001084 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 313603001085 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 313603001086 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 313603001087 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 313603001088 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 313603001089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 313603001090 Walker A/P-loop; other site 313603001091 ATP binding site [chemical binding]; other site 313603001092 Q-loop/lid; other site 313603001093 ABC transporter signature motif; other site 313603001094 Walker B; other site 313603001095 D-loop; other site 313603001096 H-loop/switch region; other site 313603001097 ABC transporter; Region: ABC_tran_2; pfam12848 313603001098 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 313603001099 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 313603001100 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 313603001101 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 313603001102 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 313603001103 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 313603001104 nucleotide binding region [chemical binding]; other site 313603001105 ATP-binding site [chemical binding]; other site 313603001106 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603001107 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603001108 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 313603001109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 313603001110 Histidine kinase; Region: HisKA_2; pfam07568 313603001111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603001112 ATP binding site [chemical binding]; other site 313603001113 Mg2+ binding site [ion binding]; other site 313603001114 G-X-G motif; other site 313603001115 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 313603001116 putative active site [active] 313603001117 Zn binding site [ion binding]; other site 313603001118 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 313603001119 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603001120 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603001121 Amidohydrolase; Region: Amidohydro_4; pfam13147 313603001122 active site 313603001123 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603001124 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603001125 Sulfatase; Region: Sulfatase; pfam00884 313603001126 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 313603001127 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 313603001128 active site 313603001129 metal binding site [ion binding]; metal-binding site 313603001130 Dienelactone hydrolase family; Region: DLH; pfam01738 313603001131 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 313603001132 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 313603001133 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 313603001134 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 313603001135 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603001136 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603001137 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603001138 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603001139 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 313603001140 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 313603001141 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603001142 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 313603001143 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 313603001144 active site 313603001145 catalytic residues [active] 313603001146 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 313603001147 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 313603001148 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 313603001149 Ligand binding site; other site 313603001150 Putative Catalytic site; other site 313603001151 DXD motif; other site 313603001152 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 313603001153 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 313603001154 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 313603001155 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 313603001156 active site 313603001157 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 313603001158 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 313603001159 multidrug efflux protein; Reviewed; Region: PRK01766 313603001160 cation binding site [ion binding]; other site 313603001161 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 313603001162 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 313603001163 homodimer interface [polypeptide binding]; other site 313603001164 metal binding site [ion binding]; metal-binding site 313603001165 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 313603001166 homodimer interface [polypeptide binding]; other site 313603001167 active site 313603001168 putative chemical substrate binding site [chemical binding]; other site 313603001169 metal binding site [ion binding]; metal-binding site 313603001170 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 313603001171 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 313603001172 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 313603001173 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 313603001174 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 313603001175 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 313603001176 catalytic triad [active] 313603001177 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 313603001178 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 313603001179 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 313603001180 putative ligand binding site [chemical binding]; other site 313603001181 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 313603001182 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603001183 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603001184 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 313603001185 amphipathic channel; other site 313603001186 Asn-Pro-Ala signature motifs; other site 313603001187 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 313603001188 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502 313603001189 active site 313603001190 catalytic triad [active] 313603001191 oxyanion hole [active] 313603001192 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 313603001193 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 313603001194 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 313603001195 active site 313603001196 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 313603001197 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 313603001198 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 313603001199 active site 313603001200 catalytic residues [active] 313603001201 metal binding site [ion binding]; metal-binding site 313603001202 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 313603001203 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 313603001204 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 313603001205 trimer interface [polypeptide binding]; other site 313603001206 active site 313603001207 substrate binding site [chemical binding]; other site 313603001208 CoA binding site [chemical binding]; other site 313603001209 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 313603001210 putative metal binding site; other site 313603001211 LicD family; Region: LicD; pfam04991 313603001212 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 313603001213 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 313603001214 active site 313603001215 nucleotide binding site [chemical binding]; other site 313603001216 HIGH motif; other site 313603001217 KMSKS motif; other site 313603001218 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 313603001219 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 313603001220 active site 313603001221 metal-binding site 313603001222 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 313603001223 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 313603001224 putative metal binding site; other site 313603001225 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 313603001226 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 313603001227 active site 313603001228 NTP binding site [chemical binding]; other site 313603001229 metal binding triad [ion binding]; metal-binding site 313603001230 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 313603001231 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 313603001232 Zn2+ binding site [ion binding]; other site 313603001233 Mg2+ binding site [ion binding]; other site 313603001234 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 313603001235 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 313603001236 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 313603001237 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 313603001238 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 313603001239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 313603001240 Walker A/P-loop; other site 313603001241 ATP binding site [chemical binding]; other site 313603001242 Q-loop/lid; other site 313603001243 ABC transporter signature motif; other site 313603001244 Walker B; other site 313603001245 D-loop; other site 313603001246 H-loop/switch region; other site 313603001247 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 313603001248 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 313603001249 Immunoglobulin domain; Region: Ig; cl11960 313603001250 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 313603001251 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 313603001252 excinuclease ABC subunit B; Provisional; Region: PRK05298 313603001253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 313603001254 ATP binding site [chemical binding]; other site 313603001255 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 313603001256 nucleotide binding region [chemical binding]; other site 313603001257 ATP-binding site [chemical binding]; other site 313603001258 Ultra-violet resistance protein B; Region: UvrB; pfam12344 313603001259 UvrB/uvrC motif; Region: UVR; pfam02151 313603001260 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 313603001261 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 313603001262 putative dimer interface [polypeptide binding]; other site 313603001263 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 313603001264 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 313603001265 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 313603001266 CoA-ligase; Region: Ligase_CoA; pfam00549 313603001267 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 313603001268 diaminopimelate decarboxylase; Region: lysA; TIGR01048 313603001269 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 313603001270 active site 313603001271 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 313603001272 substrate binding site [chemical binding]; other site 313603001273 catalytic residues [active] 313603001274 dimer interface [polypeptide binding]; other site 313603001275 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 313603001276 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 313603001277 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 313603001278 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 313603001279 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 313603001280 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 313603001281 active site 313603001282 FMN-binding domain; Region: FMN_bind; pfam04205 313603001283 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 313603001284 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 313603001285 active site 313603001286 catalytic residues [active] 313603001287 metal binding site [ion binding]; metal-binding site 313603001288 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 313603001289 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 313603001290 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 313603001291 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 313603001292 quinone interaction residues [chemical binding]; other site 313603001293 active site 313603001294 catalytic residues [active] 313603001295 FMN binding site [chemical binding]; other site 313603001296 substrate binding site [chemical binding]; other site 313603001297 peptidase T; Region: peptidase-T; TIGR01882 313603001298 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 313603001299 metal binding site [ion binding]; metal-binding site 313603001300 dimer interface [polypeptide binding]; other site 313603001301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 313603001302 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 313603001303 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 313603001304 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603001305 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603001306 Preprotein translocase subunit; Region: YajC; pfam02699 313603001307 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 313603001308 transcription antitermination factor NusB; Region: nusB; TIGR01951 313603001309 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 313603001310 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 313603001311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 313603001312 Walker A/P-loop; other site 313603001313 ATP binding site [chemical binding]; other site 313603001314 Q-loop/lid; other site 313603001315 ABC transporter signature motif; other site 313603001316 Walker B; other site 313603001317 D-loop; other site 313603001318 H-loop/switch region; other site 313603001319 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 313603001320 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 313603001321 putative active site [active] 313603001322 Zn binding site [ion binding]; other site 313603001323 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 313603001324 conserved cys residue [active] 313603001325 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 313603001326 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 313603001327 putative acyl-acceptor binding pocket; other site 313603001328 bile acid transporter; Region: bass; TIGR00841 313603001329 Sodium Bile acid symporter family; Region: SBF; cl17470 313603001330 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 313603001331 dimer interface [polypeptide binding]; other site 313603001332 putative tRNA-binding site [nucleotide binding]; other site 313603001333 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 313603001334 putative catalytic residue [active] 313603001335 metal-dependent hydrolase; Provisional; Region: PRK13291 313603001336 DinB superfamily; Region: DinB_2; pfam12867 313603001337 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 313603001338 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 313603001339 dimer interface [polypeptide binding]; other site 313603001340 decamer (pentamer of dimers) interface [polypeptide binding]; other site 313603001341 catalytic triad [active] 313603001342 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 313603001343 DNA-binding site [nucleotide binding]; DNA binding site 313603001344 RNA-binding motif; other site 313603001345 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 313603001346 active site 313603001347 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 313603001348 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 313603001349 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 313603001350 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 313603001351 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 313603001352 PA/protease or protease-like domain interface [polypeptide binding]; other site 313603001353 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 313603001354 Peptidase family M28; Region: Peptidase_M28; pfam04389 313603001355 metal binding site [ion binding]; metal-binding site 313603001356 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 313603001357 Response regulator receiver domain; Region: Response_reg; pfam00072 313603001358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603001359 active site 313603001360 phosphorylation site [posttranslational modification] 313603001361 intermolecular recognition site; other site 313603001362 dimerization interface [polypeptide binding]; other site 313603001363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603001364 Walker A motif; other site 313603001365 ATP binding site [chemical binding]; other site 313603001366 Walker B motif; other site 313603001367 arginine finger; other site 313603001368 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 313603001369 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 313603001370 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 313603001371 Walker A/P-loop; other site 313603001372 ATP binding site [chemical binding]; other site 313603001373 Q-loop/lid; other site 313603001374 ABC transporter signature motif; other site 313603001375 Walker B; other site 313603001376 D-loop; other site 313603001377 H-loop/switch region; other site 313603001378 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 313603001379 chaperone protein DnaJ; Provisional; Region: PRK14289 313603001380 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 313603001381 HSP70 interaction site [polypeptide binding]; other site 313603001382 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 313603001383 substrate binding site [polypeptide binding]; other site 313603001384 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 313603001385 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 313603001386 dimer interface [polypeptide binding]; other site 313603001387 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 313603001388 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 313603001389 dimer interface [polypeptide binding]; other site 313603001390 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 313603001391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603001392 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 313603001393 NAD(P) binding site [chemical binding]; other site 313603001394 active site 313603001395 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 313603001396 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 313603001397 substrate-cofactor binding pocket; other site 313603001398 homodimer interface [polypeptide binding]; other site 313603001399 catalytic residue [active] 313603001400 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 313603001401 metal binding site [ion binding]; metal-binding site 313603001402 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 313603001403 Nitrogen regulatory protein P-II; Region: P-II; smart00938 313603001404 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 313603001405 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 313603001406 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 313603001407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603001408 Major Facilitator Superfamily; Region: MFS_1; pfam07690 313603001409 putative substrate translocation pore; other site 313603001410 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 313603001411 DJ-1 family protein; Region: not_thiJ; TIGR01383 313603001412 conserved cys residue [active] 313603001413 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 313603001414 Mechanosensitive ion channel; Region: MS_channel; pfam00924 313603001415 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 313603001416 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 313603001417 putative DNA binding site [nucleotide binding]; other site 313603001418 putative Zn2+ binding site [ion binding]; other site 313603001419 AsnC family; Region: AsnC_trans_reg; pfam01037 313603001420 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 313603001421 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 313603001422 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 313603001423 putative active site [active] 313603001424 putative substrate binding site [chemical binding]; other site 313603001425 putative cosubstrate binding site; other site 313603001426 catalytic site [active] 313603001427 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 313603001428 Helix-turn-helix domain; Region: HTH_18; pfam12833 313603001429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603001430 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 313603001431 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603001432 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 313603001433 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603001434 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 313603001435 starch binding outer membrane protein SusD; Region: SusD; cl17845 313603001436 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 313603001437 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 313603001438 active site 313603001439 dimer interface [polypeptide binding]; other site 313603001440 peptide chain release factor 1; Validated; Region: prfA; PRK00591 313603001441 PCRF domain; Region: PCRF; pfam03462 313603001442 RF-1 domain; Region: RF-1; pfam00472 313603001443 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 313603001444 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 313603001445 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 313603001446 ApbE family; Region: ApbE; pfam02424 313603001447 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 313603001448 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 313603001449 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 313603001450 iron-sulfur cluster [ion binding]; other site 313603001451 [2Fe-2S] cluster binding site [ion binding]; other site 313603001452 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 313603001453 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 313603001454 dimerization interface [polypeptide binding]; other site 313603001455 ATP binding site [chemical binding]; other site 313603001456 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 313603001457 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 313603001458 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 313603001459 glutamine synthetase; Region: PLN02284 313603001460 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 313603001461 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 313603001462 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603001463 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 313603001464 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 313603001465 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 313603001466 Penicillinase repressor; Region: Pencillinase_R; pfam03965 313603001467 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 313603001468 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 313603001469 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 313603001470 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 313603001471 active site 313603001472 Family description; Region: VCBS; pfam13517 313603001473 Family description; Region: VCBS; pfam13517 313603001474 Family description; Region: VCBS; pfam13517 313603001475 Family description; Region: VCBS; pfam13517 313603001476 Family description; Region: VCBS; pfam13517 313603001477 Family description; Region: VCBS; pfam13517 313603001478 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 313603001479 Family description; Region: VCBS; pfam13517 313603001480 Family description; Region: VCBS; pfam13517 313603001481 Family description; Region: VCBS; pfam13517 313603001482 Family description; Region: VCBS; pfam13517 313603001483 starch binding outer membrane protein SusD; Region: SusD; cl17845 313603001484 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 313603001485 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603001486 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 313603001487 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603001488 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 313603001489 Glyco_18 domain; Region: Glyco_18; smart00636 313603001490 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 313603001491 active site 313603001492 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 313603001493 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 313603001494 Peptide-N-glycosidase F, N terminal; Region: N-glycanase_N; pfam09112 313603001495 Peptide-N-glycosidase F, C terminal; Region: N-glycanase_C; pfam09113 313603001496 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 313603001497 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 313603001498 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 313603001499 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 313603001500 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 313603001501 putative ligand binding site [chemical binding]; other site 313603001502 Domain of unknown function (DUF377); Region: DUF377; pfam04041 313603001503 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 313603001504 active site 313603001505 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 313603001506 Na binding site [ion binding]; other site 313603001507 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 313603001508 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 313603001509 Histidine kinase; Region: His_kinase; pfam06580 313603001510 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 313603001511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603001512 active site 313603001513 phosphorylation site [posttranslational modification] 313603001514 intermolecular recognition site; other site 313603001515 dimerization interface [polypeptide binding]; other site 313603001516 LytTr DNA-binding domain; Region: LytTR; smart00850 313603001517 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 313603001518 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 313603001519 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 313603001520 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 313603001521 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 313603001522 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 313603001523 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 313603001524 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 313603001525 Leucine rich repeat; Region: LRR_8; pfam13855 313603001526 Fn3 associated; Region: Fn3_assoc; pfam13287 313603001527 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 313603001528 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 313603001529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603001530 Coenzyme A binding pocket [chemical binding]; other site 313603001531 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 313603001532 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 313603001533 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 313603001534 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 313603001535 putative active site [active] 313603001536 catalytic triad [active] 313603001537 putative dimer interface [polypeptide binding]; other site 313603001538 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603001539 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603001540 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 313603001541 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 313603001542 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 313603001543 active site 313603001544 catalytic tetrad [active] 313603001545 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 313603001546 Repair protein; Region: Repair_PSII; pfam04536 313603001547 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 313603001548 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 313603001549 DNA binding site [nucleotide binding] 313603001550 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 313603001551 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 313603001552 Right handed beta helix region; Region: Beta_helix; pfam13229 313603001553 Domain of unknown function (DUF303); Region: DUF303; pfam03629 313603001554 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 313603001555 active site 313603001556 catalytic residues [active] 313603001557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603001558 S-adenosylmethionine binding site [chemical binding]; other site 313603001559 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 313603001560 Amidohydrolase; Region: Amidohydro_2; pfam04909 313603001561 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 313603001562 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 313603001563 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 313603001564 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 313603001565 Sulphur transport; Region: Sulf_transp; pfam04143 313603001566 Predicted transporter component [General function prediction only]; Region: COG2391 313603001567 Sulphur transport; Region: Sulf_transp; pfam04143 313603001568 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 313603001569 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 313603001570 catalytic domain interface [polypeptide binding]; other site 313603001571 homodimer interface [polypeptide binding]; other site 313603001572 putative active site [active] 313603001573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603001574 MFS/sugar transport protein; Region: MFS_2; pfam13347 313603001575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603001576 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 313603001577 active site 313603001578 catalytic residues [active] 313603001579 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 313603001580 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 313603001581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603001582 S-adenosylmethionine binding site [chemical binding]; other site 313603001583 triosephosphate isomerase; Provisional; Region: PRK14567 313603001584 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 313603001585 substrate binding site [chemical binding]; other site 313603001586 dimer interface [polypeptide binding]; other site 313603001587 catalytic triad [active] 313603001588 Predicted membrane protein [Function unknown]; Region: COG2259 313603001589 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 313603001590 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 313603001591 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 313603001592 dihydropteroate synthase; Region: DHPS; TIGR01496 313603001593 substrate binding pocket [chemical binding]; other site 313603001594 dimer interface [polypeptide binding]; other site 313603001595 inhibitor binding site; inhibition site 313603001596 TIGR00159 family protein; Region: TIGR00159 313603001597 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 313603001598 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 313603001599 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 313603001600 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 313603001601 Walker A/P-loop; other site 313603001602 ATP binding site [chemical binding]; other site 313603001603 Q-loop/lid; other site 313603001604 ABC transporter signature motif; other site 313603001605 Walker B; other site 313603001606 D-loop; other site 313603001607 H-loop/switch region; other site 313603001608 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 313603001609 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 313603001610 active site 313603001611 dimerization interface 3.5A [polypeptide binding]; other site 313603001612 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 313603001613 active site 313603001614 metal binding site [ion binding]; metal-binding site 313603001615 homotetramer interface [polypeptide binding]; other site 313603001616 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 313603001617 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 313603001618 transcription termination factor Rho; Provisional; Region: rho; PRK09376 313603001619 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 313603001620 RNA binding site [nucleotide binding]; other site 313603001621 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 313603001622 multimer interface [polypeptide binding]; other site 313603001623 Walker A motif; other site 313603001624 ATP binding site [chemical binding]; other site 313603001625 Walker B motif; other site 313603001626 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 313603001627 prolyl-tRNA synthetase; Provisional; Region: PRK08661 313603001628 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 313603001629 dimer interface [polypeptide binding]; other site 313603001630 motif 1; other site 313603001631 active site 313603001632 motif 2; other site 313603001633 motif 3; other site 313603001634 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 313603001635 anticodon binding site; other site 313603001636 zinc-binding site [ion binding]; other site 313603001637 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 313603001638 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 313603001639 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 313603001640 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 313603001641 GTP cyclohydrolase I; Provisional; Region: PLN03044 313603001642 active site 313603001643 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 313603001644 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 313603001645 active site 313603001646 HIGH motif; other site 313603001647 nucleotide binding site [chemical binding]; other site 313603001648 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 313603001649 KMSKS motif; other site 313603001650 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 313603001651 tRNA binding surface [nucleotide binding]; other site 313603001652 anticodon binding site; other site 313603001653 Haemolytic domain; Region: Haemolytic; pfam01809 313603001654 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 313603001655 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 313603001656 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 313603001657 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 313603001658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 313603001659 ABC transporter signature motif; other site 313603001660 Walker B; other site 313603001661 D-loop; other site 313603001662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 313603001663 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 313603001664 Walker A/P-loop; other site 313603001665 ATP binding site [chemical binding]; other site 313603001666 Q-loop/lid; other site 313603001667 ABC transporter signature motif; other site 313603001668 Walker B; other site 313603001669 D-loop; other site 313603001670 H-loop/switch region; other site 313603001671 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 313603001672 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 313603001673 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 313603001674 Protein export membrane protein; Region: SecD_SecF; pfam02355 313603001675 malate dehydrogenase; Reviewed; Region: PRK06223 313603001676 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 313603001677 dimer interface [polypeptide binding]; other site 313603001678 NAD(P) binding site [chemical binding]; other site 313603001679 tetramer (dimer of dimers) interface [polypeptide binding]; other site 313603001680 substrate binding site [chemical binding]; other site 313603001681 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 313603001682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603001683 ATP binding site [chemical binding]; other site 313603001684 Mg2+ binding site [ion binding]; other site 313603001685 G-X-G motif; other site 313603001686 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 313603001687 anchoring element; other site 313603001688 dimer interface [polypeptide binding]; other site 313603001689 ATP binding site [chemical binding]; other site 313603001690 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 313603001691 active site 313603001692 putative metal-binding site [ion binding]; other site 313603001693 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 313603001694 asparagine synthetase B; Provisional; Region: asnB; PRK09431 313603001695 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 313603001696 active site 313603001697 dimer interface [polypeptide binding]; other site 313603001698 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 313603001699 Ligand Binding Site [chemical binding]; other site 313603001700 Molecular Tunnel; other site 313603001701 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 313603001702 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_1; cd05678 313603001703 hypothetical protein; Provisional; Region: PRK08201 313603001704 putative metal binding site [ion binding]; other site 313603001705 putative dimer interface [polypeptide binding]; other site 313603001706 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 313603001707 putative metal binding site [ion binding]; other site 313603001708 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 313603001709 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 313603001710 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 313603001711 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 313603001712 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 313603001713 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 313603001714 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 313603001715 protein binding site [polypeptide binding]; other site 313603001716 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 313603001717 Domain interface; other site 313603001718 Peptide binding site; other site 313603001719 Active site tetrad [active] 313603001720 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 313603001721 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 313603001722 DNA-binding site [nucleotide binding]; DNA binding site 313603001723 RNA-binding motif; other site 313603001724 Major Facilitator Superfamily; Region: MFS_1; pfam07690 313603001725 NIPSNAP; Region: NIPSNAP; pfam07978 313603001726 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 313603001727 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 313603001728 ligand binding site [chemical binding]; other site 313603001729 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603001730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603001731 binding surface 313603001732 TPR motif; other site 313603001733 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603001734 TPR motif; other site 313603001735 binding surface 313603001736 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 313603001737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603001738 TPR motif; other site 313603001739 binding surface 313603001740 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 313603001741 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 313603001742 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 313603001743 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 313603001744 Walker A/P-loop; other site 313603001745 ATP binding site [chemical binding]; other site 313603001746 Q-loop/lid; other site 313603001747 ABC transporter signature motif; other site 313603001748 Walker B; other site 313603001749 D-loop; other site 313603001750 H-loop/switch region; other site 313603001751 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 313603001752 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 313603001753 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 313603001754 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 313603001755 nucleotide binding site [chemical binding]; other site 313603001756 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 313603001757 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 313603001758 G2 box; other site 313603001759 Switch I region; other site 313603001760 G3 box; other site 313603001761 Switch II region; other site 313603001762 GTP/Mg2+ binding site [chemical binding]; other site 313603001763 G4 box; other site 313603001764 G5 box; other site 313603001765 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 313603001766 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 313603001767 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 313603001768 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 313603001769 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603001770 Sulfatase; Region: Sulfatase; pfam00884 313603001771 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603001772 Sulfatase; Region: Sulfatase; cl17466 313603001773 Polymerase and Histidinol Phosphatase domain of Chlorobi like; Region: PHP_HisPPase_Chlorobi_like; cd12112 313603001774 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 313603001775 active site 313603001776 dimer interface [polypeptide binding]; other site 313603001777 Sulfatase; Region: Sulfatase; cl17466 313603001778 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603001779 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 313603001780 Inner membrane protein CreD; Region: CreD; pfam06123 313603001781 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 313603001782 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 313603001783 active site 313603001784 ligand binding site [chemical binding]; other site 313603001785 NAD(P) binding site [chemical binding]; other site 313603001786 Part of AAA domain; Region: AAA_19; pfam13245 313603001787 Family description; Region: UvrD_C_2; pfam13538 313603001788 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 313603001789 TPR repeat; Region: TPR_11; pfam13414 313603001790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603001791 binding surface 313603001792 TPR motif; other site 313603001793 TPR repeat; Region: TPR_11; pfam13414 313603001794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603001795 Tetratricopeptide repeat; Region: TPR_16; pfam13432 313603001796 TPR motif; other site 313603001797 binding surface 313603001798 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 313603001799 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 313603001800 Methyltransferase domain; Region: Methyltransf_26; pfam13659 313603001801 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 313603001802 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 313603001803 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 313603001804 DEAD-like helicases superfamily; Region: DEXDc; smart00487 313603001805 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 313603001806 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 313603001807 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 313603001808 nucleotide binding region [chemical binding]; other site 313603001809 ATP-binding site [chemical binding]; other site 313603001810 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 313603001811 Helix-turn-helix domain; Region: HTH_17; pfam12728 313603001812 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 313603001813 active site 313603001814 Int/Topo IB signature motif; other site 313603001815 DNA binding site [nucleotide binding] 313603001816 Predicted membrane protein [Function unknown]; Region: COG4270 313603001817 Transcriptional regulators [Transcription]; Region: FadR; COG2186 313603001818 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 313603001819 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 313603001820 substrate binding site [chemical binding]; other site 313603001821 ATP binding site [chemical binding]; other site 313603001822 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 313603001823 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 313603001824 active site 313603001825 intersubunit interface [polypeptide binding]; other site 313603001826 catalytic residue [active] 313603001827 galactonate dehydratase; Provisional; Region: PRK14017 313603001828 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 313603001829 putative active site pocket [active] 313603001830 putative metal binding site [ion binding]; other site 313603001831 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 313603001832 fructuronate transporter; Provisional; Region: PRK10034; cl15264 313603001833 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 313603001834 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 313603001835 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 313603001836 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 313603001837 catalytic residues [active] 313603001838 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 313603001839 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 313603001840 active site 313603001841 metal binding site [ion binding]; metal-binding site 313603001842 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 313603001843 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 313603001844 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 313603001845 Fn3 associated; Region: Fn3_assoc; pfam13287 313603001846 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 313603001847 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 313603001848 active site 313603001849 catalytic residues [active] 313603001850 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 313603001851 Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994 313603001852 active site 313603001853 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 313603001854 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 313603001855 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603001856 Sulfatase; Region: Sulfatase; pfam00884 313603001857 Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994 313603001858 active site 313603001859 Sulfatase; Region: Sulfatase; cl17466 313603001860 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 313603001861 Domain of unknown function (DUF303); Region: DUF303; pfam03629 313603001862 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603001863 Sulfatase; Region: Sulfatase; pfam00884 313603001864 Right handed beta helix region; Region: Beta_helix; pfam13229 313603001865 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 313603001866 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 313603001867 protein binding site [polypeptide binding]; other site 313603001868 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 313603001869 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 313603001870 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 313603001871 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 313603001872 sugar binding site [chemical binding]; other site 313603001873 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 313603001874 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 313603001875 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 313603001876 active site 313603001877 catalytic site [active] 313603001878 substrate binding site [chemical binding]; other site 313603001879 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 313603001880 GIY-YIG motif/motif A; other site 313603001881 active site 313603001882 catalytic site [active] 313603001883 putative DNA binding site [nucleotide binding]; other site 313603001884 metal binding site [ion binding]; metal-binding site 313603001885 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 313603001886 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 313603001887 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603001888 active site residue [active] 313603001889 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603001890 active site residue [active] 313603001891 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 313603001892 high affinity sulphate transporter 1; Region: sulP; TIGR00815 313603001893 Sulfate transporter family; Region: Sulfate_transp; pfam00916 313603001894 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 313603001895 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 313603001896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603001897 Coenzyme A binding pocket [chemical binding]; other site 313603001898 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 313603001899 active site 313603001900 catalytic residues [active] 313603001901 hypothetical protein; Provisional; Region: PRK07338 313603001902 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 313603001903 metal binding site [ion binding]; metal-binding site 313603001904 dimer interface [polypeptide binding]; other site 313603001905 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 313603001906 CotH protein; Region: CotH; pfam08757 313603001907 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 313603001908 FtsX-like permease family; Region: FtsX; pfam02687 313603001909 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 313603001910 Flagellin N-methylase; Region: FliB; pfam03692 313603001911 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 313603001912 Methyltransferase domain; Region: Methyltransf_31; pfam13847 313603001913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603001914 S-adenosylmethionine binding site [chemical binding]; other site 313603001915 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 313603001916 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 313603001917 AAA-like domain; Region: AAA_10; pfam12846 313603001918 Zonular occludens toxin (Zot); Region: Zot; cl17485 313603001919 Predicted transcriptional regulators [Transcription]; Region: COG1733 313603001920 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 313603001921 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 313603001922 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 313603001923 PGAP1-like protein; Region: PGAP1; pfam07819 313603001924 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 313603001925 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 313603001926 putative metal binding site [ion binding]; other site 313603001927 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 313603001928 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 313603001929 active site 313603001930 catalytic tetrad [active] 313603001931 Predicted esterase [General function prediction only]; Region: COG0627 313603001932 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 313603001933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 313603001934 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 313603001935 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 313603001936 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 313603001937 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 313603001938 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 313603001939 homodimer interface [polypeptide binding]; other site 313603001940 NADP binding site [chemical binding]; other site 313603001941 substrate binding site [chemical binding]; other site 313603001942 signal recognition particle protein; Provisional; Region: PRK10867 313603001943 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 313603001944 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 313603001945 P loop; other site 313603001946 GTP binding site [chemical binding]; other site 313603001947 Signal peptide binding domain; Region: SRP_SPB; pfam02978 313603001948 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 313603001949 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603001950 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603001951 DNA binding residues [nucleotide binding] 313603001952 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 313603001953 FecR protein; Region: FecR; pfam04773 313603001954 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603001955 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603001956 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 313603001957 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 313603001958 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 313603001959 Glyco_18 domain; Region: Glyco_18; smart00636 313603001960 The Bacteroides thetaiotaomicron protein represented by pdb structure 3CO4 is an uncharacterized bacterial member of the family 18 glycosyl hydrolases with homologs found in Flavobacterium, Stigmatella, and Pseudomonas; Region: GH18_3CO4_chitinase; cd06545 313603001961 putative active site [active] 313603001962 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 313603001963 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 313603001964 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 313603001965 active site 313603001966 HIGH motif; other site 313603001967 nucleotide binding site [chemical binding]; other site 313603001968 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 313603001969 KMSK motif region; other site 313603001970 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 313603001971 tRNA binding surface [nucleotide binding]; other site 313603001972 anticodon binding site; other site 313603001973 Amidinotransferase; Region: Amidinotransf; pfam02274 313603001974 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 313603001975 Amidinotransferase; Region: Amidinotransf; cl12043 313603001976 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 313603001977 dimer interface [polypeptide binding]; other site 313603001978 Citrate synthase; Region: Citrate_synt; pfam00285 313603001979 active site 313603001980 citrylCoA binding site [chemical binding]; other site 313603001981 NADH binding [chemical binding]; other site 313603001982 cationic pore residues; other site 313603001983 oxalacetate/citrate binding site [chemical binding]; other site 313603001984 coenzyme A binding site [chemical binding]; other site 313603001985 catalytic triad [active] 313603001986 glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095 313603001987 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 313603001988 ADP-binding pocket [chemical binding]; other site 313603001989 homodimer interface [polypeptide binding]; other site 313603001990 enolase; Provisional; Region: eno; PRK00077 313603001991 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 313603001992 dimer interface [polypeptide binding]; other site 313603001993 metal binding site [ion binding]; metal-binding site 313603001994 substrate binding pocket [chemical binding]; other site 313603001995 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 313603001996 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 313603001997 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 313603001998 catalytic site [active] 313603001999 subunit interface [polypeptide binding]; other site 313603002000 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 313603002001 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 313603002002 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 313603002003 alphaNTD homodimer interface [polypeptide binding]; other site 313603002004 alphaNTD - beta interaction site [polypeptide binding]; other site 313603002005 alphaNTD - beta' interaction site [polypeptide binding]; other site 313603002006 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 313603002007 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 313603002008 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 313603002009 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 313603002010 RNA binding surface [nucleotide binding]; other site 313603002011 30S ribosomal protein S11; Validated; Region: PRK05309 313603002012 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 313603002013 30S ribosomal protein S13; Region: bact_S13; TIGR03631 313603002014 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 313603002015 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 313603002016 rRNA binding site [nucleotide binding]; other site 313603002017 predicted 30S ribosome binding site; other site 313603002018 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 313603002019 SecY translocase; Region: SecY; pfam00344 313603002020 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 313603002021 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 313603002022 23S rRNA binding site [nucleotide binding]; other site 313603002023 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 313603002024 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 313603002025 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 313603002026 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 313603002027 5S rRNA interface [nucleotide binding]; other site 313603002028 L27 interface [polypeptide binding]; other site 313603002029 23S rRNA interface [nucleotide binding]; other site 313603002030 L5 interface [polypeptide binding]; other site 313603002031 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 313603002032 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 313603002033 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 313603002034 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 313603002035 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 313603002036 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 313603002037 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 313603002038 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 313603002039 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 313603002040 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 313603002041 RNA binding site [nucleotide binding]; other site 313603002042 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 313603002043 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 313603002044 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 313603002045 putative translocon interaction site; other site 313603002046 23S rRNA interface [nucleotide binding]; other site 313603002047 signal recognition particle (SRP54) interaction site; other site 313603002048 L23 interface [polypeptide binding]; other site 313603002049 trigger factor interaction site; other site 313603002050 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 313603002051 23S rRNA interface [nucleotide binding]; other site 313603002052 5S rRNA interface [nucleotide binding]; other site 313603002053 putative antibiotic binding site [chemical binding]; other site 313603002054 L25 interface [polypeptide binding]; other site 313603002055 L27 interface [polypeptide binding]; other site 313603002056 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 313603002057 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 313603002058 G-X-X-G motif; other site 313603002059 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 313603002060 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 313603002061 putative translocon binding site; other site 313603002062 protein-rRNA interface [nucleotide binding]; other site 313603002063 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 313603002064 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 313603002065 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 313603002066 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 313603002067 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 313603002068 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 313603002069 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 313603002070 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 313603002071 elongation factor G; Reviewed; Region: PRK12739 313603002072 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 313603002073 G1 box; other site 313603002074 putative GEF interaction site [polypeptide binding]; other site 313603002075 GTP/Mg2+ binding site [chemical binding]; other site 313603002076 Switch I region; other site 313603002077 G2 box; other site 313603002078 G3 box; other site 313603002079 Switch II region; other site 313603002080 G4 box; other site 313603002081 G5 box; other site 313603002082 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 313603002083 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 313603002084 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 313603002085 30S ribosomal protein S7; Validated; Region: PRK05302 313603002086 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 313603002087 S17 interaction site [polypeptide binding]; other site 313603002088 S8 interaction site; other site 313603002089 16S rRNA interaction site [nucleotide binding]; other site 313603002090 streptomycin interaction site [chemical binding]; other site 313603002091 23S rRNA interaction site [nucleotide binding]; other site 313603002092 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 313603002093 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 313603002094 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603002095 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 313603002096 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603002097 starch binding outer membrane protein SusD; Region: SusD; cl17845 313603002098 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 313603002099 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 313603002100 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 313603002101 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 313603002102 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 313603002103 Rhomboid family; Region: Rhomboid; cl11446 313603002104 recombination factor protein RarA; Reviewed; Region: PRK13342 313603002105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603002106 Walker A motif; other site 313603002107 ATP binding site [chemical binding]; other site 313603002108 Walker B motif; other site 313603002109 arginine finger; other site 313603002110 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 313603002111 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 313603002112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 313603002113 motif II; other site 313603002114 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 313603002115 putative active site [active] 313603002116 hypothetical protein; Reviewed; Region: PRK00024 313603002117 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 313603002118 MPN+ (JAMM) motif; other site 313603002119 Zinc-binding site [ion binding]; other site 313603002120 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 313603002121 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 313603002122 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 313603002123 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 313603002124 Cupin domain; Region: Cupin_2; pfam07883 313603002125 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 313603002126 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 313603002127 putative NAD(P) binding site [chemical binding]; other site 313603002128 putative active site [active] 313603002129 MG2 domain; Region: A2M_N; pfam01835 313603002130 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 313603002131 Alpha-2-macroglobulin family; Region: A2M; pfam00207 313603002132 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 313603002133 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 313603002134 GTPase CgtA; Reviewed; Region: obgE; PRK12299 313603002135 GTP1/OBG; Region: GTP1_OBG; pfam01018 313603002136 Obg GTPase; Region: Obg; cd01898 313603002137 G1 box; other site 313603002138 GTP/Mg2+ binding site [chemical binding]; other site 313603002139 Switch I region; other site 313603002140 G2 box; other site 313603002141 G3 box; other site 313603002142 Switch II region; other site 313603002143 G4 box; other site 313603002144 G5 box; other site 313603002145 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 313603002146 active site 313603002147 adenylate kinase; Reviewed; Region: adk; PRK00279 313603002148 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 313603002149 AMP-binding site [chemical binding]; other site 313603002150 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 313603002151 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 313603002152 ATP-grasp domain; Region: ATP-grasp; pfam02222 313603002153 AIR carboxylase; Region: AIRC; pfam00731 313603002154 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 313603002155 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 313603002156 active site 313603002157 Zn binding site [ion binding]; other site 313603002158 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603002159 active site residue [active] 313603002160 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603002161 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 313603002162 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603002163 DNA binding residues [nucleotide binding] 313603002164 glycine dehydrogenase; Provisional; Region: PRK05367 313603002165 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 313603002166 tetramer interface [polypeptide binding]; other site 313603002167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603002168 catalytic residue [active] 313603002169 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 313603002170 tetramer interface [polypeptide binding]; other site 313603002171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603002172 catalytic residue [active] 313603002173 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 313603002174 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 313603002175 dimer interface [polypeptide binding]; other site 313603002176 active site 313603002177 CoA binding pocket [chemical binding]; other site 313603002178 Methyltransferase domain; Region: Methyltransf_23; pfam13489 313603002179 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 313603002180 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 313603002181 active site 313603002182 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 313603002183 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 313603002184 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 313603002185 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 313603002186 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 313603002187 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 313603002188 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 313603002189 Surface antigen; Region: Bac_surface_Ag; pfam01103 313603002190 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 313603002191 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 313603002192 catalytic residue [active] 313603002193 putative FPP diphosphate binding site; other site 313603002194 putative FPP binding hydrophobic cleft; other site 313603002195 dimer interface [polypeptide binding]; other site 313603002196 putative IPP diphosphate binding site; other site 313603002197 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 313603002198 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911 313603002199 ATP-NAD kinase; Region: NAD_kinase; pfam01513 313603002200 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 313603002201 HipA-like C-terminal domain; Region: HipA_C; pfam07804 313603002202 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 313603002203 active site 313603002204 hydrophilic channel; other site 313603002205 dimerization interface [polypeptide binding]; other site 313603002206 catalytic residues [active] 313603002207 active site lid [active] 313603002208 acyl-CoA esterase; Provisional; Region: PRK10673 313603002209 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 313603002210 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 313603002211 catalytic site [active] 313603002212 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 313603002213 catalytic triad [active] 313603002214 Membrane protein of unknown function; Region: DUF360; pfam04020 313603002215 trigger factor; Region: tig; TIGR00115 313603002216 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 313603002217 Clp protease; Region: CLP_protease; pfam00574 313603002218 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 313603002219 oligomer interface [polypeptide binding]; other site 313603002220 active site residues [active] 313603002221 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 313603002222 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 313603002223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603002224 Walker A motif; other site 313603002225 ATP binding site [chemical binding]; other site 313603002226 Walker B motif; other site 313603002227 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 313603002228 GH3 auxin-responsive promoter; Region: GH3; pfam03321 313603002229 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 313603002230 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 313603002231 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 313603002232 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 313603002233 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 313603002234 tandem repeat interface [polypeptide binding]; other site 313603002235 oligomer interface [polypeptide binding]; other site 313603002236 active site residues [active] 313603002237 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 313603002238 tandem repeat interface [polypeptide binding]; other site 313603002239 oligomer interface [polypeptide binding]; other site 313603002240 active site residues [active] 313603002241 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 313603002242 catalytic center binding site [active] 313603002243 ATP binding site [chemical binding]; other site 313603002244 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 313603002245 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 313603002246 Substrate-binding site [chemical binding]; other site 313603002247 Substrate specificity [chemical binding]; other site 313603002248 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 313603002249 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 313603002250 MutS domain I; Region: MutS_I; pfam01624 313603002251 MutS domain II; Region: MutS_II; pfam05188 313603002252 MutS domain III; Region: MutS_III; pfam05192 313603002253 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 313603002254 Walker A/P-loop; other site 313603002255 ATP binding site [chemical binding]; other site 313603002256 Q-loop/lid; other site 313603002257 ABC transporter signature motif; other site 313603002258 Walker B; other site 313603002259 D-loop; other site 313603002260 H-loop/switch region; other site 313603002261 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 313603002262 Acyltransferase family; Region: Acyl_transf_3; pfam01757 313603002263 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 313603002264 putative active site [active] 313603002265 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 313603002266 Tetratricopeptide repeat; Region: TPR_16; pfam13432 313603002267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 313603002268 TPR motif; other site 313603002269 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 313603002270 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 313603002271 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 313603002272 ligand binding site [chemical binding]; other site 313603002273 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 313603002274 Calx-beta domain; Region: Calx-beta; cl02522 313603002275 Domain of unknown function DUF11; Region: DUF11; cl17728 313603002276 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 313603002277 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 313603002278 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 313603002279 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 313603002280 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 313603002281 trimer interface [polypeptide binding]; other site 313603002282 putative metal binding site [ion binding]; other site 313603002283 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 313603002284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603002285 active site 313603002286 phosphorylation site [posttranslational modification] 313603002287 intermolecular recognition site; other site 313603002288 dimerization interface [polypeptide binding]; other site 313603002289 LytTr DNA-binding domain; Region: LytTR; smart00850 313603002290 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603002291 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603002292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603002293 binding surface 313603002294 TPR motif; other site 313603002295 Tetratricopeptide repeat; Region: TPR_16; pfam13432 313603002296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 313603002297 TPR motif; other site 313603002298 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603002299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 313603002300 binding surface 313603002301 TPR motif; other site 313603002302 Histidine kinase; Region: His_kinase; pfam06580 313603002303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603002304 ATP binding site [chemical binding]; other site 313603002305 Mg2+ binding site [ion binding]; other site 313603002306 G-X-G motif; other site 313603002307 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 313603002308 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 313603002309 metal ion-dependent adhesion site (MIDAS); other site 313603002310 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 313603002311 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 313603002312 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 313603002313 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 313603002314 Dodecin; Region: Dodecin; pfam07311 313603002315 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 313603002316 Glycoprotease family; Region: Peptidase_M22; pfam00814 313603002317 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 313603002318 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 313603002319 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 313603002320 HlyD family secretion protein; Region: HlyD_3; pfam13437 313603002321 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603002322 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 313603002323 FtsX-like permease family; Region: FtsX; pfam02687 313603002324 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603002325 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 313603002326 FtsX-like permease family; Region: FtsX; pfam02687 313603002327 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 313603002328 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 313603002329 Walker A/P-loop; other site 313603002330 ATP binding site [chemical binding]; other site 313603002331 Q-loop/lid; other site 313603002332 ABC transporter signature motif; other site 313603002333 Walker B; other site 313603002334 D-loop; other site 313603002335 H-loop/switch region; other site 313603002336 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 313603002337 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 313603002338 HlyD family secretion protein; Region: HlyD_3; pfam13437 313603002339 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603002340 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 313603002341 FtsX-like permease family; Region: FtsX; pfam02687 313603002342 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603002343 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 313603002344 FtsX-like permease family; Region: FtsX; pfam02687 313603002345 Protein of unknown function (DUF420); Region: DUF420; pfam04238 313603002346 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 313603002347 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 313603002348 Cu(I) binding site [ion binding]; other site 313603002349 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 313603002350 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 313603002351 Subunit I/III interface [polypeptide binding]; other site 313603002352 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 313603002353 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 313603002354 Subunit I/III interface [polypeptide binding]; other site 313603002355 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 313603002356 UbiA prenyltransferase family; Region: UbiA; pfam01040 313603002357 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 313603002358 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 313603002359 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 313603002360 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 313603002361 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 313603002362 lipoyl attachment site [posttranslational modification]; other site 313603002363 cell surface protein SprA; Region: surface_SprA; TIGR04189 313603002364 Motility related/secretion protein; Region: SprA_N; pfam14349 313603002365 Motility related/secretion protein; Region: SprA_N; pfam14349 313603002366 Motility related/secretion protein; Region: SprA_N; pfam14349 313603002367 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 313603002368 RuvA N terminal domain; Region: RuvA_N; pfam01330 313603002369 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 313603002370 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 313603002371 Malic enzyme, N-terminal domain; Region: malic; pfam00390 313603002372 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 313603002373 putative NAD(P) binding site [chemical binding]; other site 313603002374 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 313603002375 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 313603002376 4Fe-4S binding domain; Region: Fer4; pfam00037 313603002377 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 313603002378 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 313603002379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603002380 Walker A motif; other site 313603002381 ATP binding site [chemical binding]; other site 313603002382 Walker B motif; other site 313603002383 arginine finger; other site 313603002384 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 313603002385 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 313603002386 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 313603002387 active site 313603002388 substrate-binding site [chemical binding]; other site 313603002389 metal-binding site [ion binding] 313603002390 ATP binding site [chemical binding]; other site 313603002391 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 313603002392 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 313603002393 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 313603002394 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 313603002395 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 313603002396 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 313603002397 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 313603002398 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 313603002399 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 313603002400 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 313603002401 Uncharacterized conserved protein [Function unknown]; Region: COG3743 313603002402 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 313603002403 molybdopterin cofactor binding site; other site 313603002404 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 313603002405 4Fe-4S binding domain; Region: Fer4; cl02805 313603002406 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 313603002407 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 313603002408 Cytochrome c; Region: Cytochrom_C; pfam00034 313603002409 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 313603002410 heme-binding residues [chemical binding]; other site 313603002411 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 313603002412 heme-binding residues [chemical binding]; other site 313603002413 Sporulation related domain; Region: SPOR; pfam05036 313603002414 translation initiation factor IF-2; Region: IF-2; TIGR00487 313603002415 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 313603002416 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 313603002417 G1 box; other site 313603002418 putative GEF interaction site [polypeptide binding]; other site 313603002419 GTP/Mg2+ binding site [chemical binding]; other site 313603002420 Switch I region; other site 313603002421 G2 box; other site 313603002422 G3 box; other site 313603002423 Switch II region; other site 313603002424 G4 box; other site 313603002425 G5 box; other site 313603002426 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 313603002427 Translation-initiation factor 2; Region: IF-2; pfam11987 313603002428 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 313603002429 transcription termination factor NusA; Region: NusA; TIGR01953 313603002430 NusA N-terminal domain; Region: NusA_N; pfam08529 313603002431 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 313603002432 RNA binding site [nucleotide binding]; other site 313603002433 homodimer interface [polypeptide binding]; other site 313603002434 NusA-like KH domain; Region: KH_5; pfam13184 313603002435 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 313603002436 G-X-X-G motif; other site 313603002437 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 313603002438 Sm and related proteins; Region: Sm_like; cl00259 313603002439 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 313603002440 putative oligomer interface [polypeptide binding]; other site 313603002441 putative RNA binding site [nucleotide binding]; other site 313603002442 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 313603002443 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 313603002444 catalytic residues [active] 313603002445 phosphodiesterase YaeI; Provisional; Region: PRK11340 313603002446 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 313603002447 putative active site [active] 313603002448 putative metal binding site [ion binding]; other site 313603002449 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 313603002450 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 313603002451 active site 313603002452 dimer interface [polypeptide binding]; other site 313603002453 catalytic nucleophile [active] 313603002454 DNA polymerase I; Provisional; Region: PRK05755 313603002455 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 313603002456 active site 313603002457 metal binding site 1 [ion binding]; metal-binding site 313603002458 putative 5' ssDNA interaction site; other site 313603002459 metal binding site 3; metal-binding site 313603002460 metal binding site 2 [ion binding]; metal-binding site 313603002461 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 313603002462 putative DNA binding site [nucleotide binding]; other site 313603002463 putative metal binding site [ion binding]; other site 313603002464 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 313603002465 active site 313603002466 catalytic site [active] 313603002467 substrate binding site [chemical binding]; other site 313603002468 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 313603002469 active site 313603002470 DNA binding site [nucleotide binding] 313603002471 catalytic site [active] 313603002472 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 313603002473 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 313603002474 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 313603002475 putative ligand binding site [chemical binding]; other site 313603002476 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 313603002477 putative ligand binding site [chemical binding]; other site 313603002478 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 313603002479 23S rRNA interface [nucleotide binding]; other site 313603002480 L3 interface [polypeptide binding]; other site 313603002481 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 313603002482 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 313603002483 rRNA interaction site [nucleotide binding]; other site 313603002484 S8 interaction site; other site 313603002485 putative laminin-1 binding site; other site 313603002486 elongation factor Ts; Provisional; Region: tsf; PRK09377 313603002487 UBA/TS-N domain; Region: UBA; pfam00627 313603002488 Elongation factor TS; Region: EF_TS; pfam00889 313603002489 Elongation factor TS; Region: EF_TS; pfam00889 313603002490 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 313603002491 putative nucleotide binding site [chemical binding]; other site 313603002492 uridine monophosphate binding site [chemical binding]; other site 313603002493 homohexameric interface [polypeptide binding]; other site 313603002494 ribosome recycling factor; Reviewed; Region: frr; PRK00083 313603002495 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 313603002496 hinge region; other site 313603002497 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 313603002498 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 313603002499 putative dimer interface [polypeptide binding]; other site 313603002500 putative anticodon binding site; other site 313603002501 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 313603002502 homodimer interface [polypeptide binding]; other site 313603002503 motif 1; other site 313603002504 motif 2; other site 313603002505 active site 313603002506 motif 3; other site 313603002507 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 313603002508 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 313603002509 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 313603002510 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 313603002511 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 313603002512 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 313603002513 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 313603002514 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 313603002515 active site 313603002516 homodimer interface [polypeptide binding]; other site 313603002517 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 313603002518 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 313603002519 active site 313603002520 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 313603002521 catalytic motif [active] 313603002522 Catalytic residue [active] 313603002523 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 313603002524 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 313603002525 E3 interaction surface; other site 313603002526 lipoyl attachment site [posttranslational modification]; other site 313603002527 e3 binding domain; Region: E3_binding; pfam02817 313603002528 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 313603002529 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 313603002530 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 313603002531 TPP-binding site [chemical binding]; other site 313603002532 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 313603002533 dimer interface [polypeptide binding]; other site 313603002534 PYR/PP interface [polypeptide binding]; other site 313603002535 TPP binding site [chemical binding]; other site 313603002536 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 313603002537 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603002538 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 313603002539 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 313603002540 active site 313603002541 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 313603002542 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 313603002543 NAD binding site [chemical binding]; other site 313603002544 homodimer interface [polypeptide binding]; other site 313603002545 active site 313603002546 substrate binding site [chemical binding]; other site 313603002547 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 313603002548 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 313603002549 inhibitor-cofactor binding pocket; inhibition site 313603002550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603002551 catalytic residue [active] 313603002552 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 313603002553 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 313603002554 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 313603002555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603002556 putative substrate translocation pore; other site 313603002557 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603002558 Sulfatase; Region: Sulfatase; pfam00884 313603002559 Sulfatase; Region: Sulfatase; cl17466 313603002560 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603002561 Sulfatase; Region: Sulfatase; cl17466 313603002562 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 313603002563 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 313603002564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603002565 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 313603002566 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 313603002567 putative NAD(P) binding site [chemical binding]; other site 313603002568 catalytic Zn binding site [ion binding]; other site 313603002569 structural Zn binding site [ion binding]; other site 313603002570 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 313603002571 galactarate dehydratase; Region: galactar-dH20; TIGR03248 313603002572 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 313603002573 altronate oxidoreductase; Provisional; Region: PRK03643 313603002574 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 313603002575 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 313603002576 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 313603002577 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 313603002578 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 313603002579 Amidohydrolase; Region: Amidohydro_2; pfam04909 313603002580 short chain dehydrogenase; Provisional; Region: PRK08628 313603002581 classical (c) SDRs; Region: SDR_c; cd05233 313603002582 NAD(P) binding site [chemical binding]; other site 313603002583 active site 313603002584 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 313603002585 L-fucose transporter; Provisional; Region: PRK10133; cl17665 313603002586 Sulfatase; Region: Sulfatase; cl17466 313603002587 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603002588 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 313603002589 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 313603002590 catalytic residues [active] 313603002591 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 313603002592 metal binding site [ion binding]; metal-binding site 313603002593 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 313603002594 hypothetical protein; Provisional; Region: PRK08201 313603002595 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 313603002596 metal binding site [ion binding]; metal-binding site 313603002597 putative dimer interface [polypeptide binding]; other site 313603002598 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 313603002599 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 313603002600 PhnA protein; Region: PhnA; pfam03831 313603002601 Penicillinase repressor; Region: Pencillinase_R; cl17580 313603002602 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 313603002603 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 313603002604 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 313603002605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603002606 active site 313603002607 phosphorylation site [posttranslational modification] 313603002608 intermolecular recognition site; other site 313603002609 dimerization interface [polypeptide binding]; other site 313603002610 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 313603002611 Ligand binding site; other site 313603002612 Ligand binding site; other site 313603002613 Ligand binding site; other site 313603002614 Putative Catalytic site; other site 313603002615 DXD motif; other site 313603002616 Predicted integral membrane protein [Function unknown]; Region: COG5617 313603002617 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 313603002618 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 313603002619 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 313603002620 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 313603002621 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 313603002622 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 313603002623 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 313603002624 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 313603002625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603002626 TPR motif; other site 313603002627 binding surface 313603002628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603002629 binding surface 313603002630 TPR motif; other site 313603002631 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 313603002632 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 313603002633 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 313603002634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603002635 active site 313603002636 phosphorylation site [posttranslational modification] 313603002637 intermolecular recognition site; other site 313603002638 dimerization interface [polypeptide binding]; other site 313603002639 LytTr DNA-binding domain; Region: LytTR; smart00850 313603002640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 313603002641 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 313603002642 putative active site [active] 313603002643 heme pocket [chemical binding]; other site 313603002644 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 313603002645 putative active site [active] 313603002646 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 313603002647 heme pocket [chemical binding]; other site 313603002648 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 313603002649 dimer interface [polypeptide binding]; other site 313603002650 phosphorylation site [posttranslational modification] 313603002651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603002652 ATP binding site [chemical binding]; other site 313603002653 Mg2+ binding site [ion binding]; other site 313603002654 G-X-G motif; other site 313603002655 Heme NO binding; Region: HNOB; pfam07700 313603002656 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 313603002657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603002658 active site 313603002659 phosphorylation site [posttranslational modification] 313603002660 intermolecular recognition site; other site 313603002661 dimerization interface [polypeptide binding]; other site 313603002662 Protein of unknown function (DUF998); Region: DUF998; pfam06197 313603002663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 313603002664 Walker A/P-loop; other site 313603002665 ATP binding site [chemical binding]; other site 313603002666 Q-loop/lid; other site 313603002667 ABC transporter signature motif; other site 313603002668 Walker B; other site 313603002669 D-loop; other site 313603002670 H-loop/switch region; other site 313603002671 DinB superfamily; Region: DinB_2; pfam12867 313603002672 Protein of unknown function (DUF419); Region: DUF419; pfam04237 313603002673 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 313603002674 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 313603002675 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 313603002676 Putative cyclase; Region: Cyclase; pfam04199 313603002677 Putative cyclase; Region: Cyclase; cl00814 313603002678 putative oxygen-independent coproporphyrinogen III oxidase; Region: hemN_rel; TIGR00539 313603002679 HemN C-terminal domain; Region: HemN_C; pfam06969 313603002680 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 313603002681 active site 313603002682 putative DNA-binding cleft [nucleotide binding]; other site 313603002683 dimer interface [polypeptide binding]; other site 313603002684 Gram-negative bacterial tonB protein; Region: TonB; cl10048 313603002685 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 313603002686 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 313603002687 Domain interface; other site 313603002688 Peptide binding site; other site 313603002689 Active site tetrad [active] 313603002690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603002691 binding surface 313603002692 Tetratricopeptide repeat; Region: TPR_16; pfam13432 313603002693 TPR motif; other site 313603002694 Tetratricopeptide repeat; Region: TPR_16; pfam13432 313603002695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603002696 binding surface 313603002697 TPR motif; other site 313603002698 TPR repeat; Region: TPR_11; pfam13414 313603002699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603002700 binding surface 313603002701 TPR motif; other site 313603002702 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 313603002703 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 313603002704 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 313603002705 Penicillinase repressor; Region: Pencillinase_R; pfam03965 313603002706 Protein of unknown function (DUF456); Region: DUF456; pfam04306 313603002707 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 313603002708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 313603002709 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 313603002710 putative dimerization interface [polypeptide binding]; other site 313603002711 putative substrate binding pocket [chemical binding]; other site 313603002712 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 313603002713 active sites [active] 313603002714 tetramer interface [polypeptide binding]; other site 313603002715 imidazolonepropionase; Validated; Region: PRK09356 313603002716 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603002717 active site 313603002718 urocanate hydratase; Provisional; Region: PRK05414 313603002719 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 313603002720 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 313603002721 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 313603002722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603002723 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 313603002724 putative active site [active] 313603002725 putative metal binding site [ion binding]; other site 313603002726 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 313603002727 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 313603002728 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 313603002729 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 313603002730 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 313603002731 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603002732 Ligand Binding Site [chemical binding]; other site 313603002733 Universal stress protein family; Region: Usp; pfam00582 313603002734 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 313603002735 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 313603002736 ligand binding site [chemical binding]; other site 313603002737 flexible hinge region; other site 313603002738 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 313603002739 putative switch regulator; other site 313603002740 non-specific DNA interactions [nucleotide binding]; other site 313603002741 DNA binding site [nucleotide binding] 313603002742 sequence specific DNA binding site [nucleotide binding]; other site 313603002743 putative cAMP binding site [chemical binding]; other site 313603002744 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 313603002745 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 313603002746 Heavy-metal-associated domain; Region: HMA; pfam00403 313603002747 metal-binding site [ion binding] 313603002748 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 313603002749 Soluble P-type ATPase [General function prediction only]; Region: COG4087 313603002750 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 313603002751 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 313603002752 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 313603002753 Low-spin heme binding site [chemical binding]; other site 313603002754 Putative water exit pathway; other site 313603002755 Binuclear center (active site) [active] 313603002756 Putative proton exit pathway; other site 313603002757 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 313603002758 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 313603002759 Cytochrome c; Region: Cytochrom_C; pfam00034 313603002760 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 313603002761 4Fe-4S binding domain; Region: Fer4_5; pfam12801 313603002762 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 313603002763 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 313603002764 FixH; Region: FixH; pfam05751 313603002765 Family description; Region: DsbD_2; pfam13386 313603002766 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 313603002767 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 313603002768 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 313603002769 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 313603002770 heme-binding site [chemical binding]; other site 313603002771 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 313603002772 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 313603002773 4Fe-4S binding domain; Region: Fer4; pfam00037 313603002774 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 313603002775 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 313603002776 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 313603002777 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 313603002778 [4Fe-4S] binding site [ion binding]; other site 313603002779 molybdopterin cofactor binding site; other site 313603002780 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 313603002781 molybdopterin cofactor binding site; other site 313603002782 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 313603002783 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 313603002784 Walker A/P-loop; other site 313603002785 ATP binding site [chemical binding]; other site 313603002786 Q-loop/lid; other site 313603002787 ABC transporter signature motif; other site 313603002788 Walker B; other site 313603002789 D-loop; other site 313603002790 H-loop/switch region; other site 313603002791 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 313603002792 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 313603002793 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 313603002794 NosL; Region: NosL; cl01769 313603002795 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 313603002796 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 313603002797 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 313603002798 Fasciclin domain; Region: Fasciclin; pfam02469 313603002799 Cytochrome c; Region: Cytochrom_C; pfam00034 313603002800 Rrf2 family protein; Region: rrf2_super; TIGR00738 313603002801 Transcriptional regulator; Region: Rrf2; pfam02082 313603002802 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603002803 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603002804 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 313603002805 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603002806 Ligand Binding Site [chemical binding]; other site 313603002807 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603002808 Ligand Binding Site [chemical binding]; other site 313603002809 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 313603002810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 313603002811 FeS/SAM binding site; other site 313603002812 HemN C-terminal domain; Region: HemN_C; pfam06969 313603002813 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 313603002814 active site 313603002815 Phosphotransferase enzyme family; Region: APH; pfam01636 313603002816 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 313603002817 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 313603002818 putative transporter; Provisional; Region: PRK10484 313603002819 Na binding site [ion binding]; other site 313603002820 xylose isomerase; Provisional; Region: PRK05474 313603002821 xylose isomerase; Region: xylose_isom_A; TIGR02630 313603002822 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 313603002823 nucleotide binding site [chemical binding]; other site 313603002824 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 313603002825 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 313603002826 mannonate dehydratase; Region: uxuA; TIGR00695 313603002827 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 313603002828 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 313603002829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603002830 NAD(P) binding site [chemical binding]; other site 313603002831 active site 313603002832 Cupin domain; Region: Cupin_2; cl17218 313603002833 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 313603002834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603002835 putative substrate translocation pore; other site 313603002836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603002837 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 313603002838 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 313603002839 N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791 313603002840 putative active site [active] 313603002841 catalytic site [active] 313603002842 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 313603002843 Transcriptional regulators [Transcription]; Region: PurR; COG1609 313603002844 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 313603002845 DNA binding site [nucleotide binding] 313603002846 domain linker motif; other site 313603002847 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 313603002848 dimerization interface [polypeptide binding]; other site 313603002849 ligand binding site [chemical binding]; other site 313603002850 Domain of unknown function (DUF303); Region: DUF303; pfam03629 313603002851 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 313603002852 Kelch motif; Region: Kelch_1; pfam01344 313603002853 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 313603002854 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 313603002855 Na binding site [ion binding]; other site 313603002856 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 313603002857 catalytic site [active] 313603002858 BNR repeat-like domain; Region: BNR_2; pfam13088 313603002859 Asp-box motif; other site 313603002860 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 313603002861 dimerization interface [polypeptide binding]; other site 313603002862 putative active cleft [active] 313603002863 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 313603002864 Class I aldolases; Region: Aldolase_Class_I; cl17187 313603002865 catalytic residue [active] 313603002866 Protein of unknown function DUF58; Region: DUF58; pfam01882 313603002867 von Willebrand factor type A domain; Region: VWA_2; pfam13519 313603002868 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 313603002869 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 313603002870 catalytic residues [active] 313603002871 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 313603002872 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 313603002873 active site 313603002874 catalytic site [active] 313603002875 substrate binding site [chemical binding]; other site 313603002876 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 313603002877 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 313603002878 active site 313603002879 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 313603002880 generic binding surface I; other site 313603002881 generic binding surface II; other site 313603002882 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603002883 Sulfatase; Region: Sulfatase; pfam00884 313603002884 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 313603002885 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 313603002886 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 313603002887 RimM N-terminal domain; Region: RimM; pfam01782 313603002888 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 313603002889 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 313603002890 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603002891 Sulfatase; Region: Sulfatase; pfam00884 313603002892 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 313603002893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603002894 S-adenosylmethionine binding site [chemical binding]; other site 313603002895 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 313603002896 Amidinotransferase; Region: Amidinotransf; pfam02274 313603002897 arginine:agmatin antiporter; Provisional; Region: PRK10644 313603002898 Spore germination protein; Region: Spore_permease; cl17796 313603002899 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 313603002900 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 313603002901 [2Fe-2S] cluster binding site [ion binding]; other site 313603002902 C-terminal catalytic domain of plant choline monooxygenase (CMO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_CMO-like; cd08883 313603002903 putative alpha subunit interface [polypeptide binding]; other site 313603002904 putative active site [active] 313603002905 putative substrate binding site [chemical binding]; other site 313603002906 Fe binding site [ion binding]; other site 313603002907 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 313603002908 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 313603002909 active site 313603002910 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 313603002911 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 313603002912 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 313603002913 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 313603002914 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 313603002915 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 313603002916 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 313603002917 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 313603002918 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 313603002919 molybdopterin cofactor binding site; other site 313603002920 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 313603002921 putative molybdopterin cofactor binding site; other site 313603002922 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 313603002923 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 313603002924 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 313603002925 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 313603002926 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 313603002927 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 313603002928 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 313603002929 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603002930 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603002931 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 313603002932 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 313603002933 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 313603002934 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603002935 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 313603002936 Predicted membrane protein [Function unknown]; Region: COG2311 313603002937 Protein of unknown function (DUF418); Region: DUF418; cl12135 313603002938 Protein of unknown function (DUF418); Region: DUF418; pfam04235 313603002939 DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594 313603002940 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 313603002941 active site 313603002942 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 313603002943 generic binding surface I; other site 313603002944 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 313603002945 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 313603002946 active site 313603002947 DNA binding site [nucleotide binding] 313603002948 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 313603002949 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603002950 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603002951 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 313603002952 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 313603002953 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 313603002954 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 313603002955 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 313603002956 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 313603002957 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 313603002958 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 313603002959 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 313603002960 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 313603002961 active site 313603002962 metal binding site [ion binding]; metal-binding site 313603002963 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 313603002964 BON domain; Region: BON; pfam04972 313603002965 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 313603002966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 313603002967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 313603002968 dimer interface [polypeptide binding]; other site 313603002969 phosphorylation site [posttranslational modification] 313603002970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603002971 ATP binding site [chemical binding]; other site 313603002972 Mg2+ binding site [ion binding]; other site 313603002973 G-X-G motif; other site 313603002974 Response regulator receiver domain; Region: Response_reg; pfam00072 313603002975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603002976 active site 313603002977 phosphorylation site [posttranslational modification] 313603002978 intermolecular recognition site; other site 313603002979 dimerization interface [polypeptide binding]; other site 313603002980 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 313603002981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603002982 active site 313603002983 phosphorylation site [posttranslational modification] 313603002984 intermolecular recognition site; other site 313603002985 dimerization interface [polypeptide binding]; other site 313603002986 LytTr DNA-binding domain; Region: LytTR; smart00850 313603002987 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 313603002988 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 313603002989 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 313603002990 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 313603002991 active site 313603002992 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 313603002993 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 313603002994 5S rRNA interface [nucleotide binding]; other site 313603002995 CTC domain interface [polypeptide binding]; other site 313603002996 L16 interface [polypeptide binding]; other site 313603002997 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 313603002998 putative active site [active] 313603002999 catalytic residue [active] 313603003000 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 313603003001 active site 313603003002 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 313603003003 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 313603003004 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 313603003005 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 313603003006 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 313603003007 active site 313603003008 Riboflavin kinase; Region: Flavokinase; pfam01687 313603003009 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 313603003010 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 313603003011 active site 313603003012 metal binding site [ion binding]; metal-binding site 313603003013 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 313603003014 seryl-tRNA synthetase; Provisional; Region: PRK05431 313603003015 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 313603003016 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 313603003017 dimer interface [polypeptide binding]; other site 313603003018 active site 313603003019 motif 1; other site 313603003020 motif 2; other site 313603003021 motif 3; other site 313603003022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603003023 TPR motif; other site 313603003024 binding surface 313603003025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603003026 binding surface 313603003027 TPR motif; other site 313603003028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 313603003029 binding surface 313603003030 TPR motif; other site 313603003031 TPR repeat; Region: TPR_11; pfam13414 313603003032 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 313603003033 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 313603003034 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 313603003035 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 313603003036 MgtE intracellular N domain; Region: MgtE_N; pfam03448 313603003037 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 313603003038 Divalent cation transporter; Region: MgtE; pfam01769 313603003039 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 313603003040 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 313603003041 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 313603003042 putative ligand binding site [chemical binding]; other site 313603003043 putative NAD binding site [chemical binding]; other site 313603003044 catalytic site [active] 313603003045 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 313603003046 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 313603003047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 313603003048 dimerization interface [polypeptide binding]; other site 313603003049 putative DNA binding site [nucleotide binding]; other site 313603003050 putative Zn2+ binding site [ion binding]; other site 313603003051 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 313603003052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603003053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 313603003054 Coenzyme A binding pocket [chemical binding]; other site 313603003055 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 313603003056 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 313603003057 putative acyl-acceptor binding pocket; other site 313603003058 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 313603003059 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 313603003060 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 313603003061 nucleotide binding site [chemical binding]; other site 313603003062 substrate binding site [chemical binding]; other site 313603003063 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 313603003064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603003065 Coenzyme A binding pocket [chemical binding]; other site 313603003066 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 313603003067 AMP binding site [chemical binding]; other site 313603003068 metal binding site [ion binding]; metal-binding site 313603003069 active site 313603003070 tellurium resistance terB-like protein; Region: terB_like; cd07177 313603003071 metal binding site [ion binding]; metal-binding site 313603003072 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 313603003073 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 313603003074 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 313603003075 ATP binding site [chemical binding]; other site 313603003076 putative Mg++ binding site [ion binding]; other site 313603003077 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 313603003078 nucleotide binding region [chemical binding]; other site 313603003079 ATP-binding site [chemical binding]; other site 313603003080 TRCF domain; Region: TRCF; pfam03461 313603003081 tellurium resistance terB-like protein; Region: terB_like; cd07177 313603003082 metal binding site [ion binding]; metal-binding site 313603003083 Predicted acyl esterases [General function prediction only]; Region: COG2936 313603003084 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 313603003085 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 313603003086 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 313603003087 catalytic residues [active] 313603003088 Family description; Region: ACT_7; pfam13840 313603003089 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 313603003090 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 313603003091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 313603003092 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 313603003093 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 313603003094 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 313603003095 active site 313603003096 HIGH motif; other site 313603003097 KMSKS motif; other site 313603003098 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 313603003099 tRNA binding surface [nucleotide binding]; other site 313603003100 anticodon binding site; other site 313603003101 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 313603003102 dimer interface [polypeptide binding]; other site 313603003103 putative tRNA-binding site [nucleotide binding]; other site 313603003104 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 313603003105 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 313603003106 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 313603003107 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 313603003108 RNA binding site [nucleotide binding]; other site 313603003109 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 313603003110 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 313603003111 active site 313603003112 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 313603003113 Ferritin-like domain; Region: Ferritin; pfam00210 313603003114 ferroxidase diiron center [ion binding]; other site 313603003115 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603003116 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603003117 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 313603003118 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 313603003119 dimer interface [polypeptide binding]; other site 313603003120 ssDNA binding site [nucleotide binding]; other site 313603003121 tetramer (dimer of dimers) interface [polypeptide binding]; other site 313603003122 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 313603003123 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 313603003124 active site 313603003125 Sulfatase; Region: Sulfatase; cl17466 313603003126 Protein of unknown function (DUF664); Region: DUF664; pfam04978 313603003127 DinB superfamily; Region: DinB_2; pfam12867 313603003128 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 313603003129 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 313603003130 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 313603003131 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 313603003132 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 313603003133 FOG: CBS domain [General function prediction only]; Region: COG0517 313603003134 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 313603003135 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 313603003136 Peptidase family M28; Region: Peptidase_M28; pfam04389 313603003137 metal binding site [ion binding]; metal-binding site 313603003138 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 313603003139 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 313603003140 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 313603003141 NADH(P)-binding; Region: NAD_binding_10; pfam13460 313603003142 putative NAD(P) binding site [chemical binding]; other site 313603003143 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 313603003144 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 313603003145 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 313603003146 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 313603003147 homodimer interface [polypeptide binding]; other site 313603003148 substrate-cofactor binding pocket; other site 313603003149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603003150 catalytic residue [active] 313603003151 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 313603003152 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 313603003153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603003154 NAD(P) binding site [chemical binding]; other site 313603003155 active site 313603003156 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 313603003157 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 313603003158 catalytic loop [active] 313603003159 iron binding site [ion binding]; other site 313603003160 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 313603003161 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 313603003162 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 313603003163 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 313603003164 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 313603003165 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 313603003166 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 313603003167 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 313603003168 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 313603003169 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 313603003170 Sulfatase; Region: Sulfatase; cl17466 313603003171 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 313603003172 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 313603003173 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 313603003174 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 313603003175 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 313603003176 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 313603003177 substrate binding pocket [chemical binding]; other site 313603003178 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 313603003179 homotrimer interaction site [polypeptide binding]; other site 313603003180 putative active site [active] 313603003181 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 313603003182 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603003183 catalytic residue [active] 313603003184 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 313603003185 homotrimer interaction site [polypeptide binding]; other site 313603003186 putative active site [active] 313603003187 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 313603003188 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 313603003189 Sodium Bile acid symporter family; Region: SBF; pfam01758 313603003190 dihydroorotase; Provisional; Region: PRK09237 313603003191 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603003192 active site 313603003193 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 313603003194 putative ligand binding site [chemical binding]; other site 313603003195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 313603003196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 313603003197 dimer interface [polypeptide binding]; other site 313603003198 phosphorylation site [posttranslational modification] 313603003199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603003200 ATP binding site [chemical binding]; other site 313603003201 Mg2+ binding site [ion binding]; other site 313603003202 G-X-G motif; other site 313603003203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603003204 Response regulator receiver domain; Region: Response_reg; pfam00072 313603003205 active site 313603003206 phosphorylation site [posttranslational modification] 313603003207 intermolecular recognition site; other site 313603003208 dimerization interface [polypeptide binding]; other site 313603003209 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 313603003210 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 313603003211 Rab subfamily motif 1 (RabSF1); other site 313603003212 G1 box; other site 313603003213 GTP/Mg2+ binding site [chemical binding]; other site 313603003214 Rab subfamily motif 2 (RabSF2); other site 313603003215 Switch I region; other site 313603003216 G2 box; other site 313603003217 effector interaction site; other site 313603003218 GDI interaction site; other site 313603003219 Rab family motif 1 (RabF1); other site 313603003220 GEF interaction site [polypeptide binding]; other site 313603003221 Rab family motif 2 (RabF2); other site 313603003222 G3 box; other site 313603003223 Switch II region; other site 313603003224 Rab family motif 3 (RabF3); other site 313603003225 Rab family motif 4 (RabF4); other site 313603003226 Rab family motif 5 (RabF5); other site 313603003227 Rab subfamily motif 3 (RabSF3); other site 313603003228 G4 box; other site 313603003229 G5 box; other site 313603003230 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 313603003231 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 313603003232 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 313603003233 active site 313603003234 AAA domain; Region: AAA_33; pfam13671 313603003235 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 313603003236 ligand-binding site [chemical binding]; other site 313603003237 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 313603003238 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 313603003239 Active Sites [active] 313603003240 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 313603003241 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 313603003242 CysD dimerization site [polypeptide binding]; other site 313603003243 G1 box; other site 313603003244 putative GEF interaction site [polypeptide binding]; other site 313603003245 GTP/Mg2+ binding site [chemical binding]; other site 313603003246 Switch I region; other site 313603003247 G2 box; other site 313603003248 G3 box; other site 313603003249 Switch II region; other site 313603003250 G4 box; other site 313603003251 G5 box; other site 313603003252 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 313603003253 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 313603003254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603003255 Major Facilitator Superfamily; Region: MFS_1; pfam07690 313603003256 putative substrate translocation pore; other site 313603003257 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 313603003258 active site 313603003259 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 313603003260 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 313603003261 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 313603003262 putative substrate binding region [chemical binding]; other site 313603003263 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 313603003264 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 313603003265 Cu(I) binding site [ion binding]; other site 313603003266 FeoA domain; Region: FeoA; pfam04023 313603003267 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 313603003268 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 313603003269 G1 box; other site 313603003270 GTP/Mg2+ binding site [chemical binding]; other site 313603003271 Switch I region; other site 313603003272 G2 box; other site 313603003273 G3 box; other site 313603003274 Switch II region; other site 313603003275 G4 box; other site 313603003276 G5 box; other site 313603003277 Nucleoside recognition; Region: Gate; pfam07670 313603003278 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 313603003279 Nucleoside recognition; Region: Gate; pfam07670 313603003280 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603003281 Protein of unknown function (DUF423); Region: DUF423; pfam04241 313603003282 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 313603003283 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 313603003284 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 313603003285 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 313603003286 NodB motif; other site 313603003287 putative active site [active] 313603003288 putative catalytic site [active] 313603003289 putative Zn binding site [ion binding]; other site 313603003290 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 313603003291 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 313603003292 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 313603003293 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 313603003294 TM1410 hypothetical-related protein; Region: DUF297; cl00997 313603003295 TM1410 hypothetical-related protein; Region: DUF297; cl00997 313603003296 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 313603003297 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 313603003298 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 313603003299 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 313603003300 FeoA domain; Region: FeoA; pfam04023 313603003301 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603003302 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 313603003303 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 313603003304 N-terminal plug; other site 313603003305 ligand-binding site [chemical binding]; other site 313603003306 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 313603003307 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 313603003308 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 313603003309 DNA-binding site [nucleotide binding]; DNA binding site 313603003310 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 313603003311 putative dimerization interface [polypeptide binding]; other site 313603003312 Transcriptional regulators [Transcription]; Region: PurR; COG1609 313603003313 putative ligand binding site [chemical binding]; other site 313603003314 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 313603003315 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603003316 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 313603003317 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 313603003318 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 313603003319 starch binding outer membrane protein SusD; Region: SusD; cl17845 313603003320 SusD family; Region: SusD; pfam07980 313603003321 Family description; Region: VCBS; pfam13517 313603003322 Family description; Region: VCBS; pfam13517 313603003323 Family description; Region: VCBS; pfam13517 313603003324 Family description; Region: VCBS; pfam13517 313603003325 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 313603003326 Family description; Region: VCBS; pfam13517 313603003327 Family description; Region: VCBS; pfam13517 313603003328 Family description; Region: VCBS; pfam13517 313603003329 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 313603003330 TM1410 hypothetical-related protein; Region: DUF297; cl00997 313603003331 catalytic site [active] 313603003332 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 313603003333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 313603003334 HEAT repeats; Region: HEAT_2; pfam13646 313603003335 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 313603003336 Cytochrome c; Region: Cytochrom_C; pfam00034 313603003337 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 313603003338 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 313603003339 heme-binding residues [chemical binding]; other site 313603003340 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 313603003341 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 313603003342 substrate binding pocket [chemical binding]; other site 313603003343 chain length determination region; other site 313603003344 substrate-Mg2+ binding site; other site 313603003345 catalytic residues [active] 313603003346 aspartate-rich region 1; other site 313603003347 active site lid residues [active] 313603003348 aspartate-rich region 2; other site 313603003349 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 313603003350 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603003351 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603003352 DNA binding residues [nucleotide binding] 313603003353 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 313603003354 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 313603003355 Outer membrane efflux protein; Region: OEP; pfam02321 313603003356 Outer membrane efflux protein; Region: OEP; pfam02321 313603003357 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 313603003358 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 313603003359 HlyD family secretion protein; Region: HlyD_3; pfam13437 313603003360 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 313603003361 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 313603003362 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 313603003363 dimer interface [polypeptide binding]; other site 313603003364 anticodon binding site; other site 313603003365 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 313603003366 homodimer interface [polypeptide binding]; other site 313603003367 motif 1; other site 313603003368 active site 313603003369 motif 2; other site 313603003370 GAD domain; Region: GAD; pfam02938 313603003371 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 313603003372 motif 3; other site 313603003373 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 313603003374 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 313603003375 Cl- selectivity filter; other site 313603003376 Cl- binding residues [ion binding]; other site 313603003377 pore gating glutamate residue; other site 313603003378 dimer interface [polypeptide binding]; other site 313603003379 FOG: CBS domain [General function prediction only]; Region: COG0517 313603003380 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 313603003381 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 313603003382 DNA-binding site [nucleotide binding]; DNA binding site 313603003383 RNA-binding motif; other site 313603003384 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 313603003385 nucleoside/Zn binding site; other site 313603003386 dimer interface [polypeptide binding]; other site 313603003387 catalytic motif [active] 313603003388 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 313603003389 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 313603003390 TPP-binding site; other site 313603003391 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 313603003392 PYR/PP interface [polypeptide binding]; other site 313603003393 dimer interface [polypeptide binding]; other site 313603003394 TPP binding site [chemical binding]; other site 313603003395 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 313603003396 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 313603003397 YceI-like domain; Region: YceI; pfam04264 313603003398 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 313603003399 Cytochrome c; Region: Cytochrom_C; cl11414 313603003400 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 313603003401 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 313603003402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 313603003403 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 313603003404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 313603003405 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 313603003406 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 313603003407 LytTr DNA-binding domain; Region: LytTR; smart00850 313603003408 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 313603003409 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 313603003410 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 313603003411 PBP superfamily domain; Region: PBP_like_2; cl17296 313603003412 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 313603003413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 313603003414 dimer interface [polypeptide binding]; other site 313603003415 conserved gate region; other site 313603003416 putative PBP binding loops; other site 313603003417 ABC-ATPase subunit interface; other site 313603003418 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 313603003419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 313603003420 dimer interface [polypeptide binding]; other site 313603003421 conserved gate region; other site 313603003422 putative PBP binding loops; other site 313603003423 ABC-ATPase subunit interface; other site 313603003424 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 313603003425 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 313603003426 Walker A/P-loop; other site 313603003427 ATP binding site [chemical binding]; other site 313603003428 Q-loop/lid; other site 313603003429 ABC transporter signature motif; other site 313603003430 Walker B; other site 313603003431 D-loop; other site 313603003432 H-loop/switch region; other site 313603003433 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 313603003434 PhoU domain; Region: PhoU; pfam01895 313603003435 PhoU domain; Region: PhoU; pfam01895 313603003436 Phosphate transporter family; Region: PHO4; pfam01384 313603003437 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 313603003438 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 313603003439 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 313603003440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603003441 putative substrate translocation pore; other site 313603003442 Phosphate transporter family; Region: PHO4; cl00396 313603003443 Phosphate transporter family; Region: PHO4; cl00396 313603003444 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 313603003445 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603003446 active site 313603003447 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603003448 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 313603003449 catalytic site [active] 313603003450 BNR repeat-like domain; Region: BNR_2; pfam13088 313603003451 Asp-box motif; other site 313603003452 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 313603003453 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 313603003454 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 313603003455 active site 313603003456 (T/H)XGH motif; other site 313603003457 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 313603003458 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 313603003459 catalytic site [active] 313603003460 G-X2-G-X-G-K; other site 313603003461 hypothetical protein; Provisional; Region: PRK11820 313603003462 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 313603003463 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 313603003464 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 313603003465 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 313603003466 Metal-binding active site; metal-binding site 313603003467 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 313603003468 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 313603003469 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603003470 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603003471 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 313603003472 DDE superfamily endonuclease; Region: DDE_5; cl17874 313603003473 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 313603003474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603003475 putative substrate translocation pore; other site 313603003476 DinB family; Region: DinB; cl17821 313603003477 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 313603003478 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 313603003479 Metal-binding active site; metal-binding site 313603003480 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 313603003481 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 313603003482 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 313603003483 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 313603003484 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 313603003485 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 313603003486 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 313603003487 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 313603003488 ATP cone domain; Region: ATP-cone; pfam03477 313603003489 Class I ribonucleotide reductase; Region: RNR_I; cd01679 313603003490 active site 313603003491 dimer interface [polypeptide binding]; other site 313603003492 catalytic residues [active] 313603003493 effector binding site; other site 313603003494 R2 peptide binding site; other site 313603003495 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 313603003496 dimer interface [polypeptide binding]; other site 313603003497 putative radical transfer pathway; other site 313603003498 diiron center [ion binding]; other site 313603003499 tyrosyl radical; other site 313603003500 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 313603003501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603003502 active site 313603003503 phosphorylation site [posttranslational modification] 313603003504 intermolecular recognition site; other site 313603003505 dimerization interface [polypeptide binding]; other site 313603003506 LytTr DNA-binding domain; Region: LytTR; smart00850 313603003507 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603003508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603003509 binding surface 313603003510 TPR motif; other site 313603003511 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603003512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603003513 binding surface 313603003514 TPR motif; other site 313603003515 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603003516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603003517 TPR motif; other site 313603003518 binding surface 313603003519 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603003520 Histidine kinase; Region: His_kinase; pfam06580 313603003521 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 313603003522 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 313603003523 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 313603003524 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 313603003525 protein binding site [polypeptide binding]; other site 313603003526 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 313603003527 Catalytic dyad [active] 313603003528 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 313603003529 catalytic motif [active] 313603003530 Zn binding site [ion binding]; other site 313603003531 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 313603003532 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 313603003533 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 313603003534 putative metal binding site [ion binding]; other site 313603003535 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 313603003536 HSP70 interaction site [polypeptide binding]; other site 313603003537 Disulphide isomerase; Region: Disulph_isomer; pfam06491 313603003538 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 313603003539 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 313603003540 putative acyl-acceptor binding pocket; other site 313603003541 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 313603003542 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 313603003543 Zn2+ binding site [ion binding]; other site 313603003544 Mg2+ binding site [ion binding]; other site 313603003545 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 313603003546 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 313603003547 FeS/SAM binding site; other site 313603003548 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 313603003549 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 313603003550 substrate binding site [chemical binding]; other site 313603003551 oxyanion hole (OAH) forming residues; other site 313603003552 trimer interface [polypeptide binding]; other site 313603003553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 313603003554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 313603003555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 313603003556 dimer interface [polypeptide binding]; other site 313603003557 phosphorylation site [posttranslational modification] 313603003558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603003559 ATP binding site [chemical binding]; other site 313603003560 Mg2+ binding site [ion binding]; other site 313603003561 G-X-G motif; other site 313603003562 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 313603003563 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 313603003564 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 313603003565 Asp-box motif; other site 313603003566 catalytic site [active] 313603003567 BNR repeat-like domain; Region: BNR_2; pfam13088 313603003568 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 313603003569 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603003570 Sulfatase; Region: Sulfatase; pfam00884 313603003571 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 313603003572 putative active site [active] 313603003573 GIY-YIG motif/motif A; other site 313603003574 putative metal binding site [ion binding]; other site 313603003575 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 313603003576 VPS10 domain; Region: VPS10; smart00602 313603003577 Asp-box motif; other site 313603003578 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 313603003579 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 313603003580 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 313603003581 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 313603003582 ferrochelatase; Reviewed; Region: hemH; PRK00035 313603003583 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 313603003584 C-terminal domain interface [polypeptide binding]; other site 313603003585 active site 313603003586 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 313603003587 active site 313603003588 N-terminal domain interface [polypeptide binding]; other site 313603003589 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 313603003590 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 313603003591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603003592 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 313603003593 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 313603003594 tRNA; other site 313603003595 putative tRNA binding site [nucleotide binding]; other site 313603003596 putative NADP binding site [chemical binding]; other site 313603003597 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 313603003598 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 313603003599 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 313603003600 domain interfaces; other site 313603003601 active site 313603003602 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 313603003603 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 313603003604 active site 313603003605 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 313603003606 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 313603003607 substrate binding site [chemical binding]; other site 313603003608 active site 313603003609 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 313603003610 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 313603003611 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 313603003612 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 313603003613 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 313603003614 DEAD-like helicases superfamily; Region: DEXDc; smart00487 313603003615 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 313603003616 ATP binding site [chemical binding]; other site 313603003617 putative Mg++ binding site [ion binding]; other site 313603003618 helicase superfamily c-terminal domain; Region: HELICc; smart00490 313603003619 ATP-binding site [chemical binding]; other site 313603003620 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 313603003621 dimer interface [polypeptide binding]; other site 313603003622 allosteric magnesium binding site [ion binding]; other site 313603003623 active site 313603003624 aspartate-rich active site metal binding site; other site 313603003625 Schiff base residues; other site 313603003626 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603003627 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603003628 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 313603003629 Domain of unknown function DUF21; Region: DUF21; pfam01595 313603003630 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 313603003631 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 313603003632 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 313603003633 DNA binding site [nucleotide binding] 313603003634 active site 313603003635 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 313603003636 active site 313603003637 catalytic site [active] 313603003638 substrate binding site [chemical binding]; other site 313603003639 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603003640 Sulfatase; Region: Sulfatase; pfam00884 313603003641 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 313603003642 putative catalytic site [active] 313603003643 putative metal binding site [ion binding]; other site 313603003644 putative phosphate binding site [ion binding]; other site 313603003645 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 313603003646 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 313603003647 HflX GTPase family; Region: HflX; cd01878 313603003648 G1 box; other site 313603003649 GTP/Mg2+ binding site [chemical binding]; other site 313603003650 Switch I region; other site 313603003651 G2 box; other site 313603003652 G3 box; other site 313603003653 Switch II region; other site 313603003654 G4 box; other site 313603003655 G5 box; other site 313603003656 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 313603003657 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 313603003658 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 313603003659 Fe-S metabolism associated domain; Region: SufE; cl00951 313603003660 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 313603003661 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 313603003662 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603003663 catalytic residue [active] 313603003664 FeS assembly protein SufD; Region: sufD; TIGR01981 313603003665 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 313603003666 FeS assembly ATPase SufC; Region: sufC; TIGR01978 313603003667 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 313603003668 Walker A/P-loop; other site 313603003669 ATP binding site [chemical binding]; other site 313603003670 Q-loop/lid; other site 313603003671 ABC transporter signature motif; other site 313603003672 Walker B; other site 313603003673 D-loop; other site 313603003674 H-loop/switch region; other site 313603003675 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 313603003676 putative ABC transporter; Region: ycf24; CHL00085 313603003677 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 313603003678 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 313603003679 Cytochrome c; Region: Cytochrom_C; cl11414 313603003680 PA14 domain; Region: PA14; cl08459 313603003681 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 313603003682 thiamine-monophosphate kinase; Region: thiL; TIGR01379 313603003683 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 313603003684 ATP binding site [chemical binding]; other site 313603003685 dimerization interface [polypeptide binding]; other site 313603003686 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 313603003687 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 313603003688 Predicted integral membrane protein [Function unknown]; Region: COG5616 313603003689 TPR repeat; Region: TPR_11; pfam13414 313603003690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603003691 TPR motif; other site 313603003692 binding surface 313603003693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603003694 binding surface 313603003695 TPR motif; other site 313603003696 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 313603003697 SnoaL-like domain; Region: SnoaL_3; pfam13474 313603003698 SnoaL-like domain; Region: SnoaL_3; pfam13474 313603003699 Predicted integral membrane protein [Function unknown]; Region: COG5615 313603003700 proline aminopeptidase P II; Provisional; Region: PRK10879 313603003701 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 313603003702 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 313603003703 active site 313603003704 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 313603003705 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 313603003706 active site 313603003707 Trehalose utilisation; Region: ThuA; pfam06283 313603003708 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 313603003709 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 313603003710 putative ligand binding site [chemical binding]; other site 313603003711 Predicted deacylase [General function prediction only]; Region: COG3608 313603003712 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 313603003713 putative active site [active] 313603003714 Zn binding site [ion binding]; other site 313603003715 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 313603003716 ATP-grasp domain; Region: ATP-grasp_4; cl17255 313603003717 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 313603003718 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 313603003719 putative Iron-sulfur protein interface [polypeptide binding]; other site 313603003720 proximal heme binding site [chemical binding]; other site 313603003721 distal heme binding site [chemical binding]; other site 313603003722 putative dimer interface [polypeptide binding]; other site 313603003723 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 313603003724 L-aspartate oxidase; Provisional; Region: PRK06175 313603003725 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 313603003726 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 313603003727 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 313603003728 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 313603003729 additional DNA contacts [nucleotide binding]; other site 313603003730 mismatch recognition site; other site 313603003731 active site 313603003732 zinc binding site [ion binding]; other site 313603003733 DNA intercalation site [nucleotide binding]; other site 313603003734 methionine aminotransferase; Validated; Region: PRK09082 313603003735 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 313603003736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603003737 homodimer interface [polypeptide binding]; other site 313603003738 catalytic residue [active] 313603003739 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 313603003740 catalytic residues [active] 313603003741 Histidine kinase; Region: His_kinase; pfam06580 313603003742 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 313603003743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603003744 active site 313603003745 phosphorylation site [posttranslational modification] 313603003746 intermolecular recognition site; other site 313603003747 dimerization interface [polypeptide binding]; other site 313603003748 LytTr DNA-binding domain; Region: LytTR; smart00850 313603003749 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603003750 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603003751 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 313603003752 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 313603003753 cellulose synthase-interactive protein; Provisional; Region: PLN03200 313603003754 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 313603003755 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 313603003756 Transglycosylase; Region: Transgly; pfam00912 313603003757 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 313603003758 GldH lipoprotein; Region: GldH_lipo; pfam14109 313603003759 PSP1 C-terminal conserved region; Region: PSP1; cl00770 313603003760 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 313603003761 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 313603003762 active site residue [active] 313603003763 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 313603003764 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 313603003765 Peptidase family U32; Region: Peptidase_U32; pfam01136 313603003766 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 313603003767 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 313603003768 hexamer interface [polypeptide binding]; other site 313603003769 Walker A motif; other site 313603003770 ATP binding site [chemical binding]; other site 313603003771 Walker B motif; other site 313603003772 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 313603003773 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603003774 DNA binding residues [nucleotide binding] 313603003775 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 313603003776 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 313603003777 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 313603003778 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 313603003779 putative acyl-acceptor binding pocket; other site 313603003780 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 313603003781 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 313603003782 active site 313603003783 HIGH motif; other site 313603003784 dimer interface [polypeptide binding]; other site 313603003785 KMSKS motif; other site 313603003786 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 313603003787 Sporulation related domain; Region: SPOR; cl10051 313603003788 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 313603003789 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 313603003790 active site 313603003791 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 313603003792 catalytic tetrad [active] 313603003793 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 313603003794 Peptidase family M23; Region: Peptidase_M23; pfam01551 313603003795 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 313603003796 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 313603003797 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 313603003798 core domain interface [polypeptide binding]; other site 313603003799 delta subunit interface [polypeptide binding]; other site 313603003800 epsilon subunit interface [polypeptide binding]; other site 313603003801 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 313603003802 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 313603003803 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 313603003804 beta subunit interaction interface [polypeptide binding]; other site 313603003805 Walker A motif; other site 313603003806 ATP binding site [chemical binding]; other site 313603003807 Walker B motif; other site 313603003808 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 313603003809 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 313603003810 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 313603003811 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471 313603003812 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 313603003813 ATP synthase subunit C; Region: ATP-synt_C; cl00466 313603003814 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 313603003815 ATP synthase A chain; Region: ATP-synt_A; cl00413 313603003816 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 313603003817 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 313603003818 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 313603003819 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 313603003820 Walker A/P-loop; other site 313603003821 ATP binding site [chemical binding]; other site 313603003822 Q-loop/lid; other site 313603003823 ABC transporter signature motif; other site 313603003824 Walker B; other site 313603003825 D-loop; other site 313603003826 H-loop/switch region; other site 313603003827 Predicted transcriptional regulators [Transcription]; Region: COG1695 313603003828 Transcriptional regulator PadR-like family; Region: PadR; cl17335 313603003829 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 313603003830 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 313603003831 FAD binding pocket [chemical binding]; other site 313603003832 FAD binding motif [chemical binding]; other site 313603003833 phosphate binding motif [ion binding]; other site 313603003834 beta-alpha-beta structure motif; other site 313603003835 NAD(p) ribose binding residues [chemical binding]; other site 313603003836 NAD binding pocket [chemical binding]; other site 313603003837 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 313603003838 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 313603003839 catalytic loop [active] 313603003840 iron binding site [ion binding]; other site 313603003841 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; pfam09837 313603003842 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 313603003843 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 313603003844 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 313603003845 FeS/SAM binding site; other site 313603003846 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 313603003847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 313603003848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 313603003849 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 313603003850 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 313603003851 putative active site [active] 313603003852 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 313603003853 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 313603003854 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 313603003855 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 313603003856 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 313603003857 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 313603003858 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 313603003859 NAD binding site [chemical binding]; other site 313603003860 putative substrate binding site 2 [chemical binding]; other site 313603003861 putative substrate binding site 1 [chemical binding]; other site 313603003862 active site 313603003863 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 313603003864 Bacterial sugar transferase; Region: Bac_transf; pfam02397 313603003865 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 313603003866 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 313603003867 O-Antigen ligase; Region: Wzy_C; cl04850 313603003868 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 313603003869 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 313603003870 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 313603003871 ligand binding site; other site 313603003872 tetramer interface; other site 313603003873 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 313603003874 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 313603003875 NADP-binding site; other site 313603003876 homotetramer interface [polypeptide binding]; other site 313603003877 substrate binding site [chemical binding]; other site 313603003878 homodimer interface [polypeptide binding]; other site 313603003879 active site 313603003880 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 313603003881 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 313603003882 inhibitor-cofactor binding pocket; inhibition site 313603003883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603003884 catalytic residue [active] 313603003885 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 313603003886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603003887 Coenzyme A binding pocket [chemical binding]; other site 313603003888 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 313603003889 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 313603003890 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 313603003891 NeuB family; Region: NeuB; pfam03102 313603003892 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 313603003893 NeuB binding interface [polypeptide binding]; other site 313603003894 putative substrate binding site [chemical binding]; other site 313603003895 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 313603003896 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 313603003897 NADP binding site [chemical binding]; other site 313603003898 active site 313603003899 putative substrate binding site [chemical binding]; other site 313603003900 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 313603003901 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 313603003902 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 313603003903 substrate binding site; other site 313603003904 tetramer interface; other site 313603003905 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 313603003906 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 313603003907 NAD binding site [chemical binding]; other site 313603003908 substrate binding site [chemical binding]; other site 313603003909 homodimer interface [polypeptide binding]; other site 313603003910 active site 313603003911 GH3 auxin-responsive promoter; Region: GH3; pfam03321 313603003912 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 313603003913 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 313603003914 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 313603003915 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 313603003916 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 313603003917 ligand binding site [chemical binding]; other site 313603003918 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 313603003919 N-acetyl-D-glucosamine binding site [chemical binding]; other site 313603003920 catalytic residue [active] 313603003921 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 313603003922 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 313603003923 Phosphoglycerate kinase; Region: PGK; pfam00162 313603003924 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 313603003925 substrate binding site [chemical binding]; other site 313603003926 hinge regions; other site 313603003927 ADP binding site [chemical binding]; other site 313603003928 catalytic site [active] 313603003929 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 313603003930 DNA polymerase III subunit delta'; Validated; Region: PRK08485 313603003931 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 313603003932 Methyltransferase domain; Region: Methyltransf_23; pfam13489 313603003933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603003934 S-adenosylmethionine binding site [chemical binding]; other site 313603003935 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 313603003936 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 313603003937 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 313603003938 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 313603003939 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 313603003940 Fatty acid desaturase; Region: FA_desaturase; pfam00487 313603003941 Di-iron ligands [ion binding]; other site 313603003942 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 313603003943 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 313603003944 HIGH motif; other site 313603003945 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 313603003946 active site 313603003947 KMSKS motif; other site 313603003948 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 313603003949 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 313603003950 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 313603003951 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 313603003952 active site 313603003953 HIGH motif; other site 313603003954 nucleotide binding site [chemical binding]; other site 313603003955 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 313603003956 active site 313603003957 KMSKS motif; other site 313603003958 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 313603003959 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 313603003960 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 313603003961 Sulfatase; Region: Sulfatase; cl17466 313603003962 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603003963 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 313603003964 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 313603003965 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 313603003966 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 313603003967 LysE type translocator; Region: LysE; cl00565 313603003968 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 313603003969 ribonuclease R; Region: RNase_R; TIGR02063 313603003970 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 313603003971 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 313603003972 RNB domain; Region: RNB; pfam00773 313603003973 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 313603003974 RNA binding site [nucleotide binding]; other site 313603003975 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 313603003976 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 313603003977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 313603003978 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603003979 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 313603003980 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 313603003981 active site 313603003982 catalytic tetrad [active] 313603003983 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 313603003984 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 313603003985 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 313603003986 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 313603003987 cofactor binding site; other site 313603003988 DNA binding site [nucleotide binding] 313603003989 substrate interaction site [chemical binding]; other site 313603003990 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 313603003991 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 313603003992 NlpC/P60 family; Region: NLPC_P60; pfam00877 313603003993 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603003994 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603003995 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 313603003996 Trp docking motif [polypeptide binding]; other site 313603003997 putative active site [active] 313603003998 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 313603003999 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 313603004000 Phosphotransferase enzyme family; Region: APH; pfam01636 313603004001 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 313603004002 active site 313603004003 ATP binding site [chemical binding]; other site 313603004004 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 313603004005 substrate binding site [chemical binding]; other site 313603004006 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 313603004007 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 313603004008 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 313603004009 active site 313603004010 catalytic triad [active] 313603004011 oxyanion hole [active] 313603004012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 313603004013 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 313603004014 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 313603004015 active site 313603004016 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 313603004017 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 313603004018 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 313603004019 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 313603004020 protein binding site [polypeptide binding]; other site 313603004021 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 313603004022 Catalytic dyad [active] 313603004023 ribonuclease P; Reviewed; Region: rnpA; PRK01903 313603004024 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 313603004025 FOG: CBS domain [General function prediction only]; Region: COG0517 313603004026 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 313603004027 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 313603004028 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily; Region: M14_ASTE_ASPA_like; cd06230 313603004029 active site 313603004030 Zn binding site [ion binding]; other site 313603004031 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 313603004032 Zn binding site [ion binding]; other site 313603004033 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 313603004034 Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483 313603004035 active site 313603004036 catalytic triad [active] 313603004037 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 313603004038 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 313603004039 Sulfate transporter family; Region: Sulfate_transp; pfam00916 313603004040 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 313603004041 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603004042 Ligand Binding Site [chemical binding]; other site 313603004043 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 313603004044 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 313603004045 TrkA-N domain; Region: TrkA_N; pfam02254 313603004046 GTP-binding protein LepA; Provisional; Region: PRK05433 313603004047 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 313603004048 G1 box; other site 313603004049 putative GEF interaction site [polypeptide binding]; other site 313603004050 GTP/Mg2+ binding site [chemical binding]; other site 313603004051 Switch I region; other site 313603004052 G2 box; other site 313603004053 G3 box; other site 313603004054 Switch II region; other site 313603004055 G4 box; other site 313603004056 G5 box; other site 313603004057 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 313603004058 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 313603004059 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 313603004060 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603004061 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 313603004062 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 313603004063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 313603004064 FeS/SAM binding site; other site 313603004065 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 313603004066 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 313603004067 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 313603004068 FMN binding site [chemical binding]; other site 313603004069 active site 313603004070 catalytic residues [active] 313603004071 substrate binding site [chemical binding]; other site 313603004072 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603004073 Ribosome-binding factor A; Region: RBFA; pfam02033 313603004074 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 313603004075 Glycosyl hydrolase family 47; Region: Glyco_hydro_47; cl08327 313603004076 Transcriptional regulators [Transcription]; Region: PurR; COG1609 313603004077 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 313603004078 DNA binding site [nucleotide binding] 313603004079 domain linker motif; other site 313603004080 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 313603004081 dimerization interface [polypeptide binding]; other site 313603004082 ligand binding site [chemical binding]; other site 313603004083 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 313603004084 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 313603004085 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 313603004086 NADP binding site [chemical binding]; other site 313603004087 homodimer interface [polypeptide binding]; other site 313603004088 active site 313603004089 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 313603004090 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 313603004091 Na binding site [ion binding]; other site 313603004092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 313603004093 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 313603004094 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 313603004095 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 313603004096 dimer interface [polypeptide binding]; other site 313603004097 active site 313603004098 CoA binding pocket [chemical binding]; other site 313603004099 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 313603004100 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 313603004101 carboxyltransferase (CT) interaction site; other site 313603004102 biotinylation site [posttranslational modification]; other site 313603004103 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 313603004104 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 313603004105 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 313603004106 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 313603004107 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 313603004108 hydroxyglutarate oxidase; Provisional; Region: PRK11728 313603004109 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 313603004110 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 313603004111 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 313603004112 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 313603004113 active site 313603004114 metal binding site [ion binding]; metal-binding site 313603004115 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 313603004116 PglZ domain; Region: PglZ; pfam08665 313603004117 hypothetical protein; Provisional; Region: PRK09256 313603004118 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 313603004119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 313603004120 Walker A/P-loop; other site 313603004121 ATP binding site [chemical binding]; other site 313603004122 Q-loop/lid; other site 313603004123 ABC transporter signature motif; other site 313603004124 Walker B; other site 313603004125 D-loop; other site 313603004126 H-loop/switch region; other site 313603004127 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 313603004128 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 313603004129 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 313603004130 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 313603004131 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 313603004132 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 313603004133 alanine racemase; Reviewed; Region: alr; PRK00053 313603004134 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 313603004135 active site 313603004136 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 313603004137 dimer interface [polypeptide binding]; other site 313603004138 substrate binding site [chemical binding]; other site 313603004139 catalytic residues [active] 313603004140 thymidine kinase; Provisional; Region: PRK04296 313603004141 DoxX-like family; Region: DoxX_2; pfam13564 313603004142 Predicted methyltransferases [General function prediction only]; Region: COG0313 313603004143 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 313603004144 putative SAM binding site [chemical binding]; other site 313603004145 putative homodimer interface [polypeptide binding]; other site 313603004146 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 313603004147 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 313603004148 putative active site [active] 313603004149 Zn binding site [ion binding]; other site 313603004150 Protein of unknown function (DUF819); Region: DUF819; cl02317 313603004151 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 313603004152 putative uracil binding site [chemical binding]; other site 313603004153 putative active site [active] 313603004154 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 313603004155 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 313603004156 DHH family; Region: DHH; pfam01368 313603004157 DHHA1 domain; Region: DHHA1; pfam02272 313603004158 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 313603004159 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 313603004160 putative metal binding site [ion binding]; other site 313603004161 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 313603004162 putative active site [active] 313603004163 putative metal binding site [ion binding]; other site 313603004164 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 313603004165 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 313603004166 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 313603004167 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 313603004168 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 313603004169 Sulfatase; Region: Sulfatase; cl17466 313603004170 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 313603004171 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 313603004172 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 313603004173 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 313603004174 Leucine rich repeat; Region: LRR_8; pfam13855 313603004175 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 313603004176 active site 313603004177 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 313603004178 active site 313603004179 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603004180 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603004181 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 313603004182 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 313603004183 substrate binding site [chemical binding]; other site 313603004184 oxyanion hole (OAH) forming residues; other site 313603004185 trimer interface [polypeptide binding]; other site 313603004186 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 313603004187 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 313603004188 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 313603004189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603004190 Coenzyme A binding pocket [chemical binding]; other site 313603004191 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603004192 Ligand Binding Site [chemical binding]; other site 313603004193 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 313603004194 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 313603004195 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 313603004196 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 313603004197 Acyltransferase family; Region: Acyl_transf_3; pfam01757 313603004198 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 313603004199 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 313603004200 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 313603004201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603004202 Predicted integral membrane protein [Function unknown]; Region: COG5616 313603004203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603004204 TPR motif; other site 313603004205 binding surface 313603004206 TPR repeat; Region: TPR_11; pfam13414 313603004207 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603004208 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603004209 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 313603004210 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 313603004211 short chain dehydrogenase; Provisional; Region: PRK07326 313603004212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603004213 NAD(P) binding site [chemical binding]; other site 313603004214 active site 313603004215 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 313603004216 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 313603004217 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 313603004218 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 313603004219 ligand binding site [chemical binding]; other site 313603004220 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 313603004221 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 313603004222 substrate-cofactor binding pocket; other site 313603004223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603004224 catalytic residue [active] 313603004225 Part of AAA domain; Region: AAA_19; pfam13245 313603004226 putative recombination protein RecB; Provisional; Region: PRK13909 313603004227 Family description; Region: UvrD_C_2; pfam13538 313603004228 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 313603004229 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 313603004230 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 313603004231 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 313603004232 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 313603004233 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 313603004234 active site 313603004235 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 313603004236 active site 313603004237 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 313603004238 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 313603004239 substrate binding site [chemical binding]; other site 313603004240 ATP binding site [chemical binding]; other site 313603004241 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 313603004242 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 313603004243 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 313603004244 RNA/DNA hybrid binding site [nucleotide binding]; other site 313603004245 active site 313603004246 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 313603004247 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 313603004248 active site 313603004249 substrate binding site [chemical binding]; other site 313603004250 cosubstrate binding site; other site 313603004251 catalytic site [active] 313603004252 acyl carrier protein; Provisional; Region: acpP; PRK00982 313603004253 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 313603004254 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 313603004255 dimer interface [polypeptide binding]; other site 313603004256 active site 313603004257 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 313603004258 dimerization interface [polypeptide binding]; other site 313603004259 active site 313603004260 metal binding site [ion binding]; metal-binding site 313603004261 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054 313603004262 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 313603004263 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 313603004264 domain interfaces; other site 313603004265 active site 313603004266 Helix-turn-helix domain; Region: HTH_18; pfam12833 313603004267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603004268 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 313603004269 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 313603004270 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 313603004271 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 313603004272 active site 313603004273 DNA polymerase IV; Validated; Region: PRK02406 313603004274 DNA binding site [nucleotide binding] 313603004275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603004276 NAD(P) binding site [chemical binding]; other site 313603004277 NADH(P)-binding; Region: NAD_binding_10; pfam13460 313603004278 active site 313603004279 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 313603004280 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 313603004281 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 313603004282 Ca binding site [ion binding]; other site 313603004283 substrate binding site [chemical binding]; other site 313603004284 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 313603004285 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 313603004286 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 313603004287 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 313603004288 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 313603004289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 313603004290 DNA-binding site [nucleotide binding]; DNA binding site 313603004291 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 313603004292 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 313603004293 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 313603004294 nucleotide binding site [chemical binding]; other site 313603004295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603004296 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 313603004297 putative substrate translocation pore; other site 313603004298 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 313603004299 putative active site [active] 313603004300 putative metal binding residues [ion binding]; other site 313603004301 signature motif; other site 313603004302 putative dimer interface [polypeptide binding]; other site 313603004303 putative phosphate binding site [ion binding]; other site 313603004304 YCII-related domain; Region: YCII; cl00999 313603004305 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 313603004306 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 313603004307 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 313603004308 dimer interface [polypeptide binding]; other site 313603004309 motif 1; other site 313603004310 active site 313603004311 motif 2; other site 313603004312 motif 3; other site 313603004313 high affinity sulphate transporter 1; Region: sulP; TIGR00815 313603004314 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 313603004315 Sulfate transporter family; Region: Sulfate_transp; pfam00916 313603004316 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 313603004317 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 313603004318 active site clefts [active] 313603004319 zinc binding site [ion binding]; other site 313603004320 dimer interface [polypeptide binding]; other site 313603004321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603004322 binding surface 313603004323 TPR repeat; Region: TPR_11; pfam13414 313603004324 TPR motif; other site 313603004325 Bacterial SH3 domain; Region: SH3_3; pfam08239 313603004326 Oxygen tolerance; Region: BatD; pfam13584 313603004327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603004328 binding surface 313603004329 TPR motif; other site 313603004330 TPR repeat; Region: TPR_11; pfam13414 313603004331 Aerotolerance regulator N-terminal; Region: BatA; cl06567 313603004332 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 313603004333 metal ion-dependent adhesion site (MIDAS); other site 313603004334 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 313603004335 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 313603004336 metal ion-dependent adhesion site (MIDAS); other site 313603004337 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 313603004338 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 313603004339 metal ion-dependent adhesion site (MIDAS); other site 313603004340 MoxR-like ATPases [General function prediction only]; Region: COG0714 313603004341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 313603004342 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 313603004343 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 313603004344 active site 313603004345 catalytic tetrad [active] 313603004346 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 313603004347 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 313603004348 putative NAD(P) binding site [chemical binding]; other site 313603004349 homotetramer interface [polypeptide binding]; other site 313603004350 homodimer interface [polypeptide binding]; other site 313603004351 active site 313603004352 Divergent AAA domain; Region: AAA_4; pfam04326 313603004353 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 313603004354 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 313603004355 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603004356 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603004357 DNA binding residues [nucleotide binding] 313603004358 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 313603004359 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 313603004360 active site residue [active] 313603004361 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 313603004362 active site residue [active] 313603004363 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 313603004364 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 313603004365 putative substrate binding site [chemical binding]; other site 313603004366 putative ATP binding site [chemical binding]; other site 313603004367 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 313603004368 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 313603004369 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 313603004370 active site 313603004371 dimer interface [polypeptide binding]; other site 313603004372 effector binding site; other site 313603004373 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 313603004374 TSCPD domain; Region: TSCPD; cl14834 313603004375 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 313603004376 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 313603004377 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 313603004378 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 313603004379 active site 313603004380 metal binding site [ion binding]; metal-binding site 313603004381 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 313603004382 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 313603004383 homodimer interface [polypeptide binding]; other site 313603004384 putative substrate binding pocket [chemical binding]; other site 313603004385 diiron center [ion binding]; other site 313603004386 Uncharacterized conserved protein [Function unknown]; Region: COG3743 313603004387 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 313603004388 ligand binding site [chemical binding]; other site 313603004389 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 313603004390 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 313603004391 ligand binding site [chemical binding]; other site 313603004392 aldehyde dehydrogenase family 7 member; Region: PLN02315 313603004393 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 313603004394 tetrameric interface [polypeptide binding]; other site 313603004395 NAD binding site [chemical binding]; other site 313603004396 catalytic residues [active] 313603004397 Sulfatase; Region: Sulfatase; cl17466 313603004398 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603004399 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 313603004400 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 313603004401 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 313603004402 MG2 domain; Region: A2M_N; pfam01835 313603004403 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 313603004404 Alpha-2-macroglobulin family; Region: A2M; pfam00207 313603004405 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 313603004406 surface patch; other site 313603004407 thioester region; other site 313603004408 specificity defining residues; other site 313603004409 ornithine cyclodeaminase; Validated; Region: PRK06141 313603004410 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 313603004411 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 313603004412 Proline racemase; Region: Pro_racemase; pfam05544 313603004413 Colicin V production protein; Region: Colicin_V; pfam02674 313603004414 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 313603004415 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 313603004416 Transglycosylase; Region: Transgly; pfam00912 313603004417 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 313603004418 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 313603004419 glycerol kinase; Provisional; Region: glpK; PRK00047 313603004420 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 313603004421 N- and C-terminal domain interface [polypeptide binding]; other site 313603004422 active site 313603004423 MgATP binding site [chemical binding]; other site 313603004424 catalytic site [active] 313603004425 metal binding site [ion binding]; metal-binding site 313603004426 glycerol binding site [chemical binding]; other site 313603004427 homotetramer interface [polypeptide binding]; other site 313603004428 homodimer interface [polypeptide binding]; other site 313603004429 FBP binding site [chemical binding]; other site 313603004430 protein IIAGlc interface [polypeptide binding]; other site 313603004431 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 313603004432 TAP-like protein; Region: Abhydrolase_4; pfam08386 313603004433 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 313603004434 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 313603004435 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 313603004436 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 313603004437 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 313603004438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603004439 Coenzyme A binding pocket [chemical binding]; other site 313603004440 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 313603004441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 313603004442 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 313603004443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603004444 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 313603004445 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 313603004446 high affinity sulphate transporter 1; Region: sulP; TIGR00815 313603004447 Sulfate transporter family; Region: Sulfate_transp; pfam00916 313603004448 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 313603004449 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 313603004450 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 313603004451 Chromate transporter; Region: Chromate_transp; pfam02417 313603004452 Cytochrome c; Region: Cytochrom_C; pfam00034 313603004453 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 313603004454 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 313603004455 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 313603004456 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 313603004457 FMN binding site [chemical binding]; other site 313603004458 substrate binding site [chemical binding]; other site 313603004459 putative catalytic residue [active] 313603004460 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 313603004461 active site 313603004462 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 313603004463 GIY-YIG motif/motif A; other site 313603004464 putative active site [active] 313603004465 putative metal binding site [ion binding]; other site 313603004466 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 313603004467 EamA-like transporter family; Region: EamA; pfam00892 313603004468 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 313603004469 ArsC family; Region: ArsC; pfam03960 313603004470 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603004471 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 313603004472 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603004473 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 313603004474 DinB superfamily; Region: DinB_2; pfam12867 313603004475 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 313603004476 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 313603004477 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 313603004478 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 313603004479 homodimer interface [polypeptide binding]; other site 313603004480 substrate-cofactor binding pocket; other site 313603004481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603004482 catalytic residue [active] 313603004483 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 313603004484 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 313603004485 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 313603004486 Ca2+ binding site [ion binding]; other site 313603004487 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 313603004488 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 313603004489 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 313603004490 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 313603004491 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 313603004492 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 313603004493 nudix motif; other site 313603004494 DinB superfamily; Region: DinB_2; pfam12867 313603004495 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 313603004496 putative ligand binding site [chemical binding]; other site 313603004497 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 313603004498 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 313603004499 putative DNA binding site [nucleotide binding]; other site 313603004500 putative Zn2+ binding site [ion binding]; other site 313603004501 AsnC family; Region: AsnC_trans_reg; pfam01037 313603004502 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 313603004503 cofactor binding site; other site 313603004504 DNA binding site [nucleotide binding] 313603004505 substrate interaction site [chemical binding]; other site 313603004506 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 313603004507 ParB-like nuclease domain; Region: ParB; smart00470 313603004508 glutamate dehydrogenase; Provisional; Region: PRK09414 313603004509 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 313603004510 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 313603004511 NAD(P) binding site [chemical binding]; other site 313603004512 Recombination protein O N terminal; Region: RecO_N; pfam11967 313603004513 DNA repair protein RecO; Region: reco; TIGR00613 313603004514 Recombination protein O C terminal; Region: RecO_C; pfam02565 313603004515 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603004516 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 313603004517 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 313603004518 N-terminal plug; other site 313603004519 ligand-binding site [chemical binding]; other site 313603004520 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 313603004521 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 313603004522 HIGH motif; other site 313603004523 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 313603004524 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 313603004525 active site 313603004526 KMSKS motif; other site 313603004527 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 313603004528 tRNA binding surface [nucleotide binding]; other site 313603004529 anticodon binding site; other site 313603004530 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 313603004531 lipoprotein signal peptidase; Provisional; Region: PRK14788 313603004532 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 313603004533 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 313603004534 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 313603004535 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 313603004536 GIY-YIG motif/motif A; other site 313603004537 active site 313603004538 catalytic site [active] 313603004539 putative DNA binding site [nucleotide binding]; other site 313603004540 metal binding site [ion binding]; metal-binding site 313603004541 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 313603004542 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 313603004543 DNA binding site [nucleotide binding] 313603004544 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 313603004545 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 313603004546 active site 313603004547 nucleophile elbow; other site 313603004548 Surface antigen; Region: Bac_surface_Ag; pfam01103 313603004549 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 313603004550 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 313603004551 dimer interface [polypeptide binding]; other site 313603004552 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 313603004553 active site 313603004554 Fe binding site [ion binding]; other site 313603004555 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 313603004556 putative peptidase; Provisional; Region: PRK11649 313603004557 Peptidase family M23; Region: Peptidase_M23; pfam01551 313603004558 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 313603004559 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 313603004560 active site 313603004561 dimer interface [polypeptide binding]; other site 313603004562 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 313603004563 dimer interface [polypeptide binding]; other site 313603004564 active site 313603004565 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603004566 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 313603004567 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603004568 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603004569 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 313603004570 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 313603004571 putative catalytic site [active] 313603004572 putative metal binding site [ion binding]; other site 313603004573 putative phosphate binding site [ion binding]; other site 313603004574 metal-dependent hydrolase; Provisional; Region: PRK13291 313603004575 DinB superfamily; Region: DinB_2; pfam12867 313603004576 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 313603004577 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 313603004578 heme binding site [chemical binding]; other site 313603004579 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 313603004580 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 313603004581 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 313603004582 nudix motif; other site 313603004583 C-N hydrolase family amidase; Provisional; Region: PRK10438 313603004584 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 313603004585 putative active site [active] 313603004586 catalytic triad [active] 313603004587 dimer interface [polypeptide binding]; other site 313603004588 multimer interface [polypeptide binding]; other site 313603004589 Bacterial Ig-like domain; Region: Big_5; pfam13205 313603004590 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 313603004591 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 313603004592 active site 313603004593 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 313603004594 glycyl-tRNA synthetase; Provisional; Region: PRK04173 313603004595 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 313603004596 motif 1; other site 313603004597 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 313603004598 active site 313603004599 motif 2; other site 313603004600 motif 3; other site 313603004601 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 313603004602 anticodon binding site; other site 313603004603 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 313603004604 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 313603004605 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 313603004606 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 313603004607 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 313603004608 FAD binding pocket [chemical binding]; other site 313603004609 FAD binding motif [chemical binding]; other site 313603004610 phosphate binding motif [ion binding]; other site 313603004611 beta-alpha-beta structure motif; other site 313603004612 NAD binding pocket [chemical binding]; other site 313603004613 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 313603004614 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 313603004615 N-terminal plug; other site 313603004616 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 313603004617 ligand-binding site [chemical binding]; other site 313603004618 Leucine rich repeat; Region: LRR_8; pfam13855 313603004619 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 313603004620 putative active site [active] 313603004621 putative catalytic site [active] 313603004622 putative DNA binding site [nucleotide binding]; other site 313603004623 putative phosphate binding site [ion binding]; other site 313603004624 metal binding site A [ion binding]; metal-binding site 313603004625 putative AP binding site [nucleotide binding]; other site 313603004626 putative metal binding site B [ion binding]; other site 313603004627 Family description; Region: VCBS; pfam13517 313603004628 Family description; Region: VCBS; pfam13517 313603004629 Family description; Region: VCBS; pfam13517 313603004630 Family description; Region: VCBS; pfam13517 313603004631 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 313603004632 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 313603004633 active site 313603004634 catalytic tetrad [active] 313603004635 DNA repair protein RadA; Provisional; Region: PRK11823 313603004636 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 313603004637 Walker A motif; other site 313603004638 ATP binding site [chemical binding]; other site 313603004639 Walker B motif; other site 313603004640 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 313603004641 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 313603004642 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 313603004643 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 313603004644 tetramerization interface [polypeptide binding]; other site 313603004645 active site 313603004646 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 313603004647 pantoate--beta-alanine ligase; Region: panC; TIGR00018 313603004648 active site 313603004649 nucleotide binding site [chemical binding]; other site 313603004650 HIGH motif; other site 313603004651 KMSKS motif; other site 313603004652 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 313603004653 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 313603004654 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 313603004655 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 313603004656 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 313603004657 glutaminase active site [active] 313603004658 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 313603004659 dimer interface [polypeptide binding]; other site 313603004660 active site 313603004661 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 313603004662 dimer interface [polypeptide binding]; other site 313603004663 active site 313603004664 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603004665 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 313603004666 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 313603004667 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603004668 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 313603004669 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 313603004670 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 313603004671 alpha subunit interaction interface [polypeptide binding]; other site 313603004672 Walker A motif; other site 313603004673 ATP binding site [chemical binding]; other site 313603004674 Walker B motif; other site 313603004675 inhibitor binding site; inhibition site 313603004676 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 313603004677 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 313603004678 gamma subunit interface [polypeptide binding]; other site 313603004679 LBP interface [polypeptide binding]; other site 313603004680 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 313603004681 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 313603004682 PDZ domain (Also known as DHR or GLGF); Region: PDZ; pfam00595 313603004683 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 313603004684 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 313603004685 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 313603004686 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 313603004687 DNA-binding site [nucleotide binding]; DNA binding site 313603004688 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 313603004689 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 313603004690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603004691 homodimer interface [polypeptide binding]; other site 313603004692 catalytic residue [active] 313603004693 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 313603004694 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 313603004695 N-terminal plug; other site 313603004696 ligand-binding site [chemical binding]; other site 313603004697 Cupin-like domain; Region: Cupin_8; pfam13621 313603004698 RecX family; Region: RecX; pfam02631 313603004699 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 313603004700 Double zinc ribbon; Region: DZR; pfam12773 313603004701 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 313603004702 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 313603004703 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 313603004704 homodimer interface [polypeptide binding]; other site 313603004705 oligonucleotide binding site [chemical binding]; other site 313603004706 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 313603004707 IHF - DNA interface [nucleotide binding]; other site 313603004708 IHF dimer interface [polypeptide binding]; other site 313603004709 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 313603004710 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 313603004711 minor groove reading motif; other site 313603004712 helix-hairpin-helix signature motif; other site 313603004713 substrate binding pocket [chemical binding]; other site 313603004714 active site 313603004715 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 313603004716 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 313603004717 DNA binding and oxoG recognition site [nucleotide binding] 313603004718 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 313603004719 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 313603004720 dimer interface [polypeptide binding]; other site 313603004721 ssDNA binding site [nucleotide binding]; other site 313603004722 tetramer (dimer of dimers) interface [polypeptide binding]; other site 313603004723 gliding motility-associated protein GldE; Region: GldE; TIGR03520 313603004724 Domain of unknown function DUF21; Region: DUF21; pfam01595 313603004725 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 313603004726 Transporter associated domain; Region: CorC_HlyC; smart01091 313603004727 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 313603004728 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 313603004729 metal-binding site [ion binding] 313603004730 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 313603004731 EamA-like transporter family; Region: EamA; pfam00892 313603004732 EamA-like transporter family; Region: EamA; pfam00892 313603004733 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 313603004734 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 313603004735 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 313603004736 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 313603004737 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 313603004738 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 313603004739 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 313603004740 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 313603004741 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 313603004742 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 313603004743 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 313603004744 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 313603004745 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 313603004746 homotetramer interface [polypeptide binding]; other site 313603004747 ligand binding site [chemical binding]; other site 313603004748 catalytic site [active] 313603004749 NAD binding site [chemical binding]; other site 313603004750 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 313603004751 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 313603004752 Domain of unknown function DUF77; Region: DUF77; cl00307 313603004753 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 313603004754 AAA domain; Region: AAA_28; pfam13521 313603004755 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 313603004756 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 313603004757 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 313603004758 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603004759 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603004760 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603004761 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 313603004762 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 313603004763 iron-sulfur cluster [ion binding]; other site 313603004764 [2Fe-2S] cluster binding site [ion binding]; other site 313603004765 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 313603004766 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 313603004767 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 313603004768 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 313603004769 nucleotide binding site/active site [active] 313603004770 HIT family signature motif; other site 313603004771 catalytic residue [active] 313603004772 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 313603004773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 313603004774 phosphorylation site [posttranslational modification] 313603004775 dimer interface [polypeptide binding]; other site 313603004776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603004777 ATP binding site [chemical binding]; other site 313603004778 Mg2+ binding site [ion binding]; other site 313603004779 G-X-G motif; other site 313603004780 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 313603004781 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 313603004782 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 313603004783 Fasciclin domain; Region: Fasciclin; pfam02469 313603004784 Fasciclin domain; Region: Fasciclin; pfam02469 313603004785 Fasciclin domain; Region: Fasciclin; pfam02469 313603004786 Fasciclin domain; Region: Fasciclin; pfam02469 313603004787 phytoene desaturase; Region: crtI_fam; TIGR02734 313603004788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 313603004789 Auxin responsive protein; Region: Auxin_inducible; cl03633 313603004790 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 313603004791 active site lid residues [active] 313603004792 substrate binding pocket [chemical binding]; other site 313603004793 catalytic residues [active] 313603004794 substrate-Mg2+ binding site; other site 313603004795 aspartate-rich region 1; other site 313603004796 aspartate-rich region 2; other site 313603004797 beta-carotene hydroxylase; Region: PLN02601 313603004798 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 313603004799 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 313603004800 TspO/MBR family; Region: TspO_MBR; pfam03073 313603004801 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 313603004802 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 313603004803 active site 313603004804 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 313603004805 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 313603004806 Uncharacterized conserved protein [Function unknown]; Region: COG1284 313603004807 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 313603004808 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 313603004809 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 313603004810 catalytic residues [active] 313603004811 Gram-negative bacterial tonB protein; Region: TonB; cl10048 313603004812 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 313603004813 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 313603004814 RNA binding site [nucleotide binding]; other site 313603004815 active site 313603004816 Bacitracin resistance protein BacA; Region: BacA; pfam02673 313603004817 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 313603004818 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 313603004819 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 313603004820 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 313603004821 active site 313603004822 HIGH motif; other site 313603004823 nucleotide binding site [chemical binding]; other site 313603004824 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 313603004825 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 313603004826 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 313603004827 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 313603004828 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 313603004829 active site 313603004830 KMSKS motif; other site 313603004831 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 313603004832 tRNA binding surface [nucleotide binding]; other site 313603004833 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 313603004834 Uncharacterized conserved protein [Function unknown]; Region: COG4095 313603004835 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 313603004836 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 313603004837 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 313603004838 AsnC family; Region: AsnC_trans_reg; pfam01037 313603004839 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 313603004840 Protein of unknown function (DUF423); Region: DUF423; pfam04241 313603004841 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 313603004842 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 313603004843 active site 313603004844 substrate-binding site [chemical binding]; other site 313603004845 metal-binding site [ion binding] 313603004846 ATP binding site [chemical binding]; other site 313603004847 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 313603004848 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 313603004849 active site 313603004850 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 313603004851 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 313603004852 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 313603004853 Ligand binding site; other site 313603004854 Putative Catalytic site; other site 313603004855 DXD motif; other site 313603004856 dihydroorotase; Reviewed; Region: PRK09236 313603004857 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603004858 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 313603004859 active site 313603004860 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 313603004861 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 313603004862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603004863 NAD(P) binding site [chemical binding]; other site 313603004864 active site 313603004865 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 313603004866 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 313603004867 active site 313603004868 HIGH motif; other site 313603004869 dimer interface [polypeptide binding]; other site 313603004870 KMSKS motif; other site 313603004871 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 313603004872 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 313603004873 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 313603004874 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 313603004875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603004876 active site 313603004877 phosphorylation site [posttranslational modification] 313603004878 intermolecular recognition site; other site 313603004879 dimerization interface [polypeptide binding]; other site 313603004880 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 313603004881 DNA binding site [nucleotide binding] 313603004882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 313603004883 dimer interface [polypeptide binding]; other site 313603004884 phosphorylation site [posttranslational modification] 313603004885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603004886 ATP binding site [chemical binding]; other site 313603004887 Mg2+ binding site [ion binding]; other site 313603004888 G-X-G motif; other site 313603004889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603004890 S-adenosylmethionine binding site [chemical binding]; other site 313603004891 LysE type translocator; Region: LysE; cl00565 313603004892 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 313603004893 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 313603004894 DNA binding site [nucleotide binding] 313603004895 active site 313603004896 PAS domain; Region: PAS; smart00091 313603004897 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 313603004898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603004899 ATP binding site [chemical binding]; other site 313603004900 Mg2+ binding site [ion binding]; other site 313603004901 G-X-G motif; other site 313603004902 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 313603004903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603004904 active site 313603004905 phosphorylation site [posttranslational modification] 313603004906 intermolecular recognition site; other site 313603004907 dimerization interface [polypeptide binding]; other site 313603004908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603004909 Walker A motif; other site 313603004910 ATP binding site [chemical binding]; other site 313603004911 Walker B motif; other site 313603004912 arginine finger; other site 313603004913 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 313603004914 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 313603004915 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 313603004916 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 313603004917 HlyD family secretion protein; Region: HlyD_3; pfam13437 313603004918 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 313603004919 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 313603004920 Walker A/P-loop; other site 313603004921 ATP binding site [chemical binding]; other site 313603004922 Q-loop/lid; other site 313603004923 ABC transporter signature motif; other site 313603004924 Walker B; other site 313603004925 D-loop; other site 313603004926 H-loop/switch region; other site 313603004927 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603004928 FtsX-like permease family; Region: FtsX; pfam02687 313603004929 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603004930 FtsX-like permease family; Region: FtsX; pfam02687 313603004931 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 313603004932 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603004933 FtsX-like permease family; Region: FtsX; pfam02687 313603004934 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603004935 FtsX-like permease family; Region: FtsX; pfam02687 313603004936 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603004937 FtsX-like permease family; Region: FtsX; pfam02687 313603004938 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 313603004939 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603004940 FtsX-like permease family; Region: FtsX; pfam02687 313603004941 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603004942 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 313603004943 FtsX-like permease family; Region: FtsX; pfam02687 313603004944 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 313603004945 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603004946 FtsX-like permease family; Region: FtsX; pfam02687 313603004947 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 313603004948 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 313603004949 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 313603004950 Walker A/P-loop; other site 313603004951 ATP binding site [chemical binding]; other site 313603004952 Q-loop/lid; other site 313603004953 ABC transporter signature motif; other site 313603004954 Walker B; other site 313603004955 D-loop; other site 313603004956 H-loop/switch region; other site 313603004957 Domain of unknown function DUF59; Region: DUF59; pfam01883 313603004958 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 313603004959 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 313603004960 Walker A motif; other site 313603004961 NifU-like domain; Region: NifU; pfam01106 313603004962 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 313603004963 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 313603004964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 313603004965 Walker A/P-loop; other site 313603004966 ATP binding site [chemical binding]; other site 313603004967 Q-loop/lid; other site 313603004968 ABC transporter signature motif; other site 313603004969 Walker B; other site 313603004970 D-loop; other site 313603004971 H-loop/switch region; other site 313603004972 Penicillin amidase; Region: Penicil_amidase; pfam01804 313603004973 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 313603004974 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 313603004975 active site 313603004976 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 313603004977 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 313603004978 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 313603004979 heme-binding residues [chemical binding]; other site 313603004980 HEAT repeats; Region: HEAT_2; pfam13646 313603004981 Tetratricopeptide repeat; Region: TPR_16; pfam13432 313603004982 Tetratricopeptide repeat; Region: TPR_16; pfam13432 313603004983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603004984 TPR motif; other site 313603004985 binding surface 313603004986 Tetratricopeptide repeat; Region: TPR_16; pfam13432 313603004987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603004988 binding surface 313603004989 Tetratricopeptide repeat; Region: TPR_16; pfam13432 313603004990 TPR motif; other site 313603004991 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00144 313603004992 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 313603004993 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 313603004994 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 313603004995 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 313603004996 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 313603004997 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 313603004998 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 313603004999 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 313603005000 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 313603005001 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 313603005002 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 313603005003 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 313603005004 NADH dehydrogenase subunit D; Validated; Region: PRK06075 313603005005 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 313603005006 NADH dehydrogenase subunit B; Validated; Region: PRK06411 313603005007 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 313603005008 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 313603005009 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 313603005010 TPP-binding site [chemical binding]; other site 313603005011 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 313603005012 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 313603005013 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 313603005014 dimer interface [polypeptide binding]; other site 313603005015 PYR/PP interface [polypeptide binding]; other site 313603005016 TPP binding site [chemical binding]; other site 313603005017 substrate binding site [chemical binding]; other site 313603005018 4Fe-4S binding domain; Region: Fer4; cl02805 313603005019 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 313603005020 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 313603005021 dimer interface [polypeptide binding]; other site 313603005022 PYR/PP interface [polypeptide binding]; other site 313603005023 TPP binding site [chemical binding]; other site 313603005024 substrate binding site [chemical binding]; other site 313603005025 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 313603005026 Domain of unknown function; Region: EKR; pfam10371 313603005027 4Fe-4S binding domain; Region: Fer4_6; pfam12837 313603005028 4Fe-4S binding domain; Region: Fer4; pfam00037 313603005029 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 313603005030 TPP-binding site [chemical binding]; other site 313603005031 dimer interface [polypeptide binding]; other site 313603005032 HEPN domain; Region: HEPN; cl00824 313603005033 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603005034 active site 313603005035 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 313603005036 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821 313603005037 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 313603005038 dimer interface [polypeptide binding]; other site 313603005039 active site 313603005040 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 313603005041 substrate binding site [chemical binding]; other site 313603005042 catalytic residue [active] 313603005043 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 313603005044 homotrimer interaction site [polypeptide binding]; other site 313603005045 putative active site [active] 313603005046 GntP family permease; Region: GntP_permease; pfam02447 313603005047 fructuronate transporter; Provisional; Region: PRK10034; cl15264 313603005048 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 313603005049 amphipathic channel; other site 313603005050 Asn-Pro-Ala signature motifs; other site 313603005051 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 313603005052 VPS10 domain; Region: VPS10; smart00602 313603005053 Ycf48-like protein; Provisional; Region: PRK13684 313603005054 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 313603005055 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 313603005056 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603005057 catalytic residue [active] 313603005058 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 313603005059 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 313603005060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 313603005061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 313603005062 Cupin domain; Region: Cupin_2; pfam07883 313603005063 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cl00238 313603005064 Methyltransferase domain; Region: Methyltransf_23; pfam13489 313603005065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603005066 S-adenosylmethionine binding site [chemical binding]; other site 313603005067 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 313603005068 tellurium resistance terB-like protein; Region: terB_like; cd07177 313603005069 metal binding site [ion binding]; metal-binding site 313603005070 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 313603005071 Predicted membrane protein [Function unknown]; Region: COG2259 313603005072 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603005073 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603005074 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 313603005075 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 313603005076 putative active site [active] 313603005077 putative metal binding site [ion binding]; other site 313603005078 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 313603005079 Zn2+ binding site [ion binding]; other site 313603005080 Mg2+ binding site [ion binding]; other site 313603005081 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 313603005082 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 313603005083 active site 313603005084 metal binding site [ion binding]; metal-binding site 313603005085 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 313603005086 Na binding site [ion binding]; other site 313603005087 substrate binding site [chemical binding]; other site 313603005088 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 313603005089 active site 313603005090 Family description; Region: VCBS; pfam13517 313603005091 Family description; Region: VCBS; pfam13517 313603005092 Family description; Region: VCBS; pfam13517 313603005093 Family description; Region: VCBS; pfam13517 313603005094 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 313603005095 Family description; Region: VCBS; pfam13517 313603005096 Family description; Region: VCBS; pfam13517 313603005097 Family description; Region: VCBS; pfam13517 313603005098 Family description; Region: VCBS; pfam13517 313603005099 Family description; Region: VCBS; pfam13517 313603005100 Family description; Region: VCBS; pfam13517 313603005101 Family description; Region: VCBS; pfam13517 313603005102 Family description; Region: VCBS; pfam13517 313603005103 Family description; Region: VCBS; pfam13517 313603005104 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 313603005105 Family description; Region: VCBS; pfam13517 313603005106 Family description; Region: VCBS; pfam13517 313603005107 Family description; Region: VCBS; pfam13517 313603005108 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 313603005109 Family description; Region: VCBS; pfam13517 313603005110 Family description; Region: VCBS; pfam13517 313603005111 Family description; Region: VCBS; pfam13517 313603005112 starch binding outer membrane protein SusD; Region: SusD; cl17845 313603005113 SusD family; Region: SusD; pfam07980 313603005114 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 313603005115 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603005116 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603005117 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 313603005118 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 313603005119 Transcriptional regulators [Transcription]; Region: PurR; COG1609 313603005120 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 313603005121 DNA binding site [nucleotide binding] 313603005122 domain linker motif; other site 313603005123 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 313603005124 dimerization interface [polypeptide binding]; other site 313603005125 ligand binding site [chemical binding]; other site 313603005126 beta-phosphoglucomutase; Region: bPGM; TIGR01990 313603005127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 313603005128 maltose phosphorylase; Provisional; Region: PRK13807 313603005129 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 313603005130 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 313603005131 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 313603005132 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 313603005133 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 313603005134 active site 313603005135 catalytic site [active] 313603005136 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 313603005137 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 313603005138 active site 313603005139 catalytic site [active] 313603005140 metal binding site [ion binding]; metal-binding site 313603005141 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 313603005142 flavoprotein, HI0933 family; Region: TIGR00275 313603005143 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 313603005144 TspO/MBR family; Region: TspO_MBR; pfam03073 313603005145 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 313603005146 diphosphomevalonate decarboxylase; Region: PLN02407 313603005147 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 313603005148 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 313603005149 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 313603005150 UbiA prenyltransferase family; Region: UbiA; pfam01040 313603005151 Predicted amidohydrolase [General function prediction only]; Region: COG0388 313603005152 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 313603005153 putative active site [active] 313603005154 catalytic triad [active] 313603005155 putative dimer interface [polypeptide binding]; other site 313603005156 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 313603005157 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 313603005158 RNA binding surface [nucleotide binding]; other site 313603005159 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 313603005160 active site 313603005161 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 313603005162 Zn binding site [ion binding]; other site 313603005163 argininosuccinate lyase; Provisional; Region: PRK00855 313603005164 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 313603005165 active sites [active] 313603005166 tetramer interface [polypeptide binding]; other site 313603005167 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 313603005168 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 313603005169 metal binding site [ion binding]; metal-binding site 313603005170 dimer interface [polypeptide binding]; other site 313603005171 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 313603005172 nucleotide binding site [chemical binding]; other site 313603005173 N-acetyl-L-glutamate binding site [chemical binding]; other site 313603005174 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 313603005175 classical (c) SDRs; Region: SDR_c; cd05233 313603005176 NAD(P) binding site [chemical binding]; other site 313603005177 active site 313603005178 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 313603005179 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 313603005180 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 313603005181 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 313603005182 nucleotide binding site [chemical binding]; other site 313603005183 homotetrameric interface [polypeptide binding]; other site 313603005184 putative phosphate binding site [ion binding]; other site 313603005185 putative allosteric binding site; other site 313603005186 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 313603005187 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 313603005188 putative catalytic cysteine [active] 313603005189 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 313603005190 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 313603005191 inhibitor-cofactor binding pocket; inhibition site 313603005192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603005193 catalytic residue [active] 313603005194 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 313603005195 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 313603005196 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 313603005197 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 313603005198 argininosuccinate synthase; Provisional; Region: PRK13820 313603005199 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 313603005200 Ligand Binding Site [chemical binding]; other site 313603005201 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603005202 Coenzyme A binding pocket [chemical binding]; other site 313603005203 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 313603005204 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 313603005205 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 313603005206 DXD motif; other site 313603005207 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 313603005208 Ligand binding site; other site 313603005209 Putative Catalytic site; other site 313603005210 DXD motif; other site 313603005211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 313603005212 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 313603005213 4Fe-4S binding domain; Region: Fer4_5; pfam12801 313603005214 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 313603005215 Protein of unknown function, DUF547; Region: DUF547; pfam04784 313603005216 Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236 313603005217 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 313603005218 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 313603005219 Surface antigen; Region: Bac_surface_Ag; pfam01103 313603005220 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 313603005221 active site 313603005222 metal binding site [ion binding]; metal-binding site 313603005223 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 313603005224 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 313603005225 Probable Catalytic site; other site 313603005226 Protein of unknown function, DUF547; Region: DUF547; pfam04784 313603005227 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 313603005228 Methyltransferase domain; Region: Methyltransf_31; pfam13847 313603005229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603005230 S-adenosylmethionine binding site [chemical binding]; other site 313603005231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 313603005232 purine nucleoside phosphorylase; Provisional; Region: PRK08202 313603005233 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 313603005234 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603005235 active site residue [active] 313603005236 pantothenate kinase; Reviewed; Region: PRK13320 313603005237 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603005238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603005239 binding surface 313603005240 TPR motif; other site 313603005241 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 313603005242 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 313603005243 Domain of unknown function DUF21; Region: DUF21; pfam01595 313603005244 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 313603005245 Transporter associated domain; Region: CorC_HlyC; smart01091 313603005246 SurA N-terminal domain; Region: SurA_N_3; cl07813 313603005247 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 313603005248 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 313603005249 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 313603005250 homodimer interface [polypeptide binding]; other site 313603005251 catalytic residues [active] 313603005252 NAD binding site [chemical binding]; other site 313603005253 substrate binding pocket [chemical binding]; other site 313603005254 flexible flap; other site 313603005255 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 313603005256 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 313603005257 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 313603005258 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 313603005259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603005260 putative substrate translocation pore; other site 313603005261 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 313603005262 Competence protein; Region: Competence; pfam03772 313603005263 NlpC/P60 family; Region: NLPC_P60; pfam00877 313603005264 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 313603005265 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 313603005266 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 313603005267 C-terminal peptidase (prc); Region: prc; TIGR00225 313603005268 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 313603005269 protein binding site [polypeptide binding]; other site 313603005270 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 313603005271 Catalytic dyad [active] 313603005272 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 313603005273 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 313603005274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603005275 putative substrate translocation pore; other site 313603005276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603005277 Uncharacterized conserved protein [Function unknown]; Region: COG0397 313603005278 hypothetical protein; Validated; Region: PRK00029 313603005279 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 313603005280 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 313603005281 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 313603005282 catalytic residues [active] 313603005283 methionine sulfoxide reductase A; Provisional; Region: PRK14054 313603005284 methionine sulfoxide reductase B; Provisional; Region: PRK00222 313603005285 SelR domain; Region: SelR; pfam01641 313603005286 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 313603005287 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 313603005288 active site 313603005289 substrate binding site [chemical binding]; other site 313603005290 Mg2+ binding site [ion binding]; other site 313603005291 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 313603005292 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 313603005293 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 313603005294 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 313603005295 rod shape-determining protein MreC; Provisional; Region: PRK13922 313603005296 rod shape-determining protein MreC; Region: MreC; pfam04085 313603005297 rod shape-determining protein MreB; Provisional; Region: PRK13927 313603005298 MreB and similar proteins; Region: MreB_like; cd10225 313603005299 nucleotide binding site [chemical binding]; other site 313603005300 Mg binding site [ion binding]; other site 313603005301 putative protofilament interaction site [polypeptide binding]; other site 313603005302 RodZ interaction site [polypeptide binding]; other site 313603005303 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 313603005304 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 313603005305 purine monophosphate binding site [chemical binding]; other site 313603005306 dimer interface [polypeptide binding]; other site 313603005307 putative catalytic residues [active] 313603005308 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 313603005309 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 313603005310 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 313603005311 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 313603005312 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 313603005313 metal-binding site [ion binding] 313603005314 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603005315 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 313603005316 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603005317 Heavy-metal-associated domain; Region: HMA; pfam00403 313603005318 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 313603005319 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 313603005320 ring oligomerisation interface [polypeptide binding]; other site 313603005321 ATP/Mg binding site [chemical binding]; other site 313603005322 stacking interactions; other site 313603005323 hinge regions; other site 313603005324 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 313603005325 oligomerisation interface [polypeptide binding]; other site 313603005326 mobile loop; other site 313603005327 roof hairpin; other site 313603005328 Lipopolysaccharide-assembly; Region: LptE; cl01125 313603005329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603005330 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 313603005331 Walker A motif; other site 313603005332 ATP binding site [chemical binding]; other site 313603005333 Walker B motif; other site 313603005334 arginine finger; other site 313603005335 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 313603005336 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 313603005337 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 313603005338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 313603005339 FeS/SAM binding site; other site 313603005340 TRAM domain; Region: TRAM; pfam01938 313603005341 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 313603005342 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 313603005343 homodimer interface [polypeptide binding]; other site 313603005344 active site 313603005345 TDP-binding site; other site 313603005346 acceptor substrate-binding pocket; other site 313603005347 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 313603005348 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603005349 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603005350 Helix-turn-helix domain; Region: HTH_18; pfam12833 313603005351 LVIVD repeat; Region: LVIVD; pfam08309 313603005352 BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure; Region: KU; cd00109 313603005353 trypsin interaction site; other site 313603005354 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 313603005355 Asp-box motif; other site 313603005356 VPS10 domain; Region: VPS10; smart00602 313603005357 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 313603005358 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 313603005359 active site 313603005360 interdomain interaction site; other site 313603005361 putative metal-binding site [ion binding]; other site 313603005362 nucleotide binding site [chemical binding]; other site 313603005363 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 313603005364 domain I; other site 313603005365 DNA binding groove [nucleotide binding] 313603005366 phosphate binding site [ion binding]; other site 313603005367 domain II; other site 313603005368 domain III; other site 313603005369 nucleotide binding site [chemical binding]; other site 313603005370 catalytic site [active] 313603005371 domain IV; other site 313603005372 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 313603005373 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 313603005374 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 313603005375 putative active site [active] 313603005376 putative metal binding site [ion binding]; other site 313603005377 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 313603005378 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 313603005379 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 313603005380 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 313603005381 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 313603005382 GldM N-terminal domain; Region: GldM_N; pfam12081 313603005383 GldM C-terminal domain; Region: GldM_C; pfam12080 313603005384 gliding motility associated protien GldN; Region: GldN; TIGR03523 313603005385 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 313603005386 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 313603005387 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 313603005388 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 313603005389 ABC transporter; Region: ABC_tran_2; pfam12848 313603005390 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 313603005391 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 313603005392 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 313603005393 MarR family; Region: MarR_2; pfam12802 313603005394 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 313603005395 HlyD family secretion protein; Region: HlyD_3; pfam13437 313603005396 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 313603005397 Protein export membrane protein; Region: SecD_SecF; cl14618 313603005398 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 313603005399 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 313603005400 CotH protein; Region: CotH; pfam08757 313603005401 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 313603005402 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 313603005403 Uncharacterized conserved protein [Function unknown]; Region: COG1262 313603005404 YceI-like domain; Region: YceI; pfam04264 313603005405 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 313603005406 ApbE family; Region: ApbE; pfam02424 313603005407 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 313603005408 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 313603005409 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 313603005410 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 313603005411 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 313603005412 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 313603005413 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 313603005414 classical (c) SDRs; Region: SDR_c; cd05233 313603005415 NAD(P) binding site [chemical binding]; other site 313603005416 active site 313603005417 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 313603005418 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 313603005419 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 313603005420 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 313603005421 GTPase Era; Reviewed; Region: era; PRK00089 313603005422 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 313603005423 G1 box; other site 313603005424 GTP/Mg2+ binding site [chemical binding]; other site 313603005425 Switch I region; other site 313603005426 G2 box; other site 313603005427 Switch II region; other site 313603005428 G3 box; other site 313603005429 G4 box; other site 313603005430 G5 box; other site 313603005431 KH domain; Region: KH_2; pfam07650 313603005432 GTP-binding protein Der; Reviewed; Region: PRK00093 313603005433 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 313603005434 G1 box; other site 313603005435 GTP/Mg2+ binding site [chemical binding]; other site 313603005436 Switch I region; other site 313603005437 G2 box; other site 313603005438 Switch II region; other site 313603005439 G3 box; other site 313603005440 G4 box; other site 313603005441 G5 box; other site 313603005442 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 313603005443 G1 box; other site 313603005444 GTP/Mg2+ binding site [chemical binding]; other site 313603005445 Switch I region; other site 313603005446 G2 box; other site 313603005447 G3 box; other site 313603005448 Switch II region; other site 313603005449 G4 box; other site 313603005450 G5 box; other site 313603005451 Repair protein; Region: Repair_PSII; pfam04536 313603005452 Repair protein; Region: Repair_PSII; pfam04536 313603005453 LemA family; Region: LemA; pfam04011 313603005454 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 313603005455 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 313603005456 DNA binding residues [nucleotide binding] 313603005457 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 313603005458 Peptidase family M23; Region: Peptidase_M23; pfam01551 313603005459 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 313603005460 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 313603005461 motif 1; other site 313603005462 active site 313603005463 motif 2; other site 313603005464 motif 3; other site 313603005465 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 313603005466 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603005467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603005468 binding surface 313603005469 TPR motif; other site 313603005470 Tetratricopeptide repeat; Region: TPR_16; pfam13432 313603005471 GSCFA family; Region: GSCFA; pfam08885 313603005472 Protein of unknown function (DUF664); Region: DUF664; pfam04978 313603005473 DinB superfamily; Region: DinB_2; pfam12867 313603005474 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 313603005475 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 313603005476 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cl01244 313603005477 cofactor binding site; other site 313603005478 metal binding site [ion binding]; metal-binding site 313603005479 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 313603005480 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 313603005481 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 313603005482 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603005483 catalytic residue [active] 313603005484 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 313603005485 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 313603005486 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 313603005487 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 313603005488 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 313603005489 inhibitor-cofactor binding pocket; inhibition site 313603005490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603005491 catalytic residue [active] 313603005492 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 313603005493 transmembrane helices; other site 313603005494 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 313603005495 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 313603005496 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 313603005497 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 313603005498 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 313603005499 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 313603005500 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 313603005501 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 313603005502 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 313603005503 dimer interface [polypeptide binding]; other site 313603005504 putative anticodon binding site; other site 313603005505 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 313603005506 motif 1; other site 313603005507 active site 313603005508 motif 2; other site 313603005509 motif 3; other site 313603005510 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 313603005511 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 313603005512 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 313603005513 RNA/DNA hybrid binding site [nucleotide binding]; other site 313603005514 active site 313603005515 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 313603005516 Haemolysin-III related; Region: HlyIII; cl03831 313603005517 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 313603005518 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 313603005519 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 313603005520 Cytochrome c; Region: Cytochrom_C; pfam00034 313603005521 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 313603005522 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 313603005523 Trehalose utilisation; Region: ThuA; pfam06283 313603005524 Transcriptional regulators [Transcription]; Region: PurR; COG1609 313603005525 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 313603005526 DNA binding site [nucleotide binding] 313603005527 domain linker motif; other site 313603005528 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 313603005529 ligand binding site [chemical binding]; other site 313603005530 dimerization interface [polypeptide binding]; other site 313603005531 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 313603005532 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603005533 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 313603005534 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 313603005535 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 313603005536 starch binding outer membrane protein SusD; Region: SusD; cl17845 313603005537 SusD family; Region: SusD; pfam07980 313603005538 Methane oxygenase PmoA; Region: PmoA; pfam14100 313603005539 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603005540 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603005541 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603005542 D-mannonate oxidoreductase; Provisional; Region: PRK08277 313603005543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603005544 NAD(P) binding site [chemical binding]; other site 313603005545 active site 313603005546 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 313603005547 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 313603005548 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 313603005549 DctM-like transporters; Region: DctM; pfam06808 313603005550 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 313603005551 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 313603005552 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 313603005553 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 313603005554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 313603005555 TRAM domain; Region: TRAM; cl01282 313603005556 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 313603005557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603005558 S-adenosylmethionine binding site [chemical binding]; other site 313603005559 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 313603005560 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603005561 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603005562 DNA binding residues [nucleotide binding] 313603005563 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 313603005564 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 313603005565 inhibitor-cofactor binding pocket; inhibition site 313603005566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603005567 catalytic residue [active] 313603005568 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 313603005569 Smr domain; Region: Smr; cl02619 313603005570 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 313603005571 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 313603005572 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603005573 catalytic residue [active] 313603005574 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603005575 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 313603005576 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603005577 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 313603005578 Peptidase family M23; Region: Peptidase_M23; pfam01551 313603005579 Cell division protein ZapA; Region: ZapA; pfam05164 313603005580 phosphodiesterase; Provisional; Region: PRK12704 313603005581 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 313603005582 Zn2+ binding site [ion binding]; other site 313603005583 Mg2+ binding site [ion binding]; other site 313603005584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603005585 putative substrate translocation pore; other site 313603005586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603005587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603005588 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 313603005589 active site 313603005590 catalytic residues [active] 313603005591 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 313603005592 starch binding outer membrane protein SusD; Region: SusD; cl17845 313603005593 SusD family; Region: SusD; pfam07980 313603005594 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 313603005595 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603005596 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 313603005597 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 313603005598 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 313603005599 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 313603005600 dimerization interface [polypeptide binding]; other site 313603005601 DNA binding residues [nucleotide binding] 313603005602 FOG: CBS domain [General function prediction only]; Region: COG0517 313603005603 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 313603005604 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 313603005605 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 313603005606 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 313603005607 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 313603005608 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 313603005609 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 313603005610 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 313603005611 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 313603005612 shikimate binding site; other site 313603005613 NAD(P) binding site [chemical binding]; other site 313603005614 Domain of unknown function (DUF368); Region: DUF368; pfam04018 313603005615 Domain of unknown function (DUF368); Region: DUF368; pfam04018 313603005616 TPR repeat; Region: TPR_11; pfam13414 313603005617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603005618 binding surface 313603005619 TPR motif; other site 313603005620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603005621 binding surface 313603005622 TPR motif; other site 313603005623 TPR repeat; Region: TPR_11; pfam13414 313603005624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603005625 binding surface 313603005626 TPR repeat; Region: TPR_11; pfam13414 313603005627 TPR motif; other site 313603005628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603005629 TPR motif; other site 313603005630 binding surface 313603005631 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 313603005632 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 313603005633 inhibitor-cofactor binding pocket; inhibition site 313603005634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603005635 catalytic residue [active] 313603005636 OstA-like protein; Region: OstA_2; pfam13100 313603005637 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 313603005638 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603005639 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603005640 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 313603005641 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603005642 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603005643 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 313603005644 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603005645 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 313603005646 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 313603005647 GDP-binding site [chemical binding]; other site 313603005648 ACT binding site; other site 313603005649 IMP binding site; other site 313603005650 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 313603005651 metal binding site 2 [ion binding]; metal-binding site 313603005652 putative DNA binding helix; other site 313603005653 metal binding site 1 [ion binding]; metal-binding site 313603005654 dimer interface [polypeptide binding]; other site 313603005655 structural Zn2+ binding site [ion binding]; other site 313603005656 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 313603005657 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 313603005658 Zn2+ binding site [ion binding]; other site 313603005659 Mg2+ binding site [ion binding]; other site 313603005660 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 313603005661 synthetase active site [active] 313603005662 NTP binding site [chemical binding]; other site 313603005663 metal binding site [ion binding]; metal-binding site 313603005664 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 313603005665 ACT domain; Region: ACT_4; pfam13291 313603005666 Peptidase family M48; Region: Peptidase_M48; pfam01435 313603005667 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 313603005668 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 313603005669 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 313603005670 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 313603005671 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 313603005672 catalytic loop [active] 313603005673 iron binding site [ion binding]; other site 313603005674 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 313603005675 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 313603005676 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 313603005677 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 313603005678 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 313603005679 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 313603005680 MoaE interaction surface [polypeptide binding]; other site 313603005681 MoeB interaction surface [polypeptide binding]; other site 313603005682 thiocarboxylated glycine; other site 313603005683 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 313603005684 MoaE homodimer interface [polypeptide binding]; other site 313603005685 MoaD interaction [polypeptide binding]; other site 313603005686 active site residues [active] 313603005687 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 313603005688 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 313603005689 FeS/SAM binding site; other site 313603005690 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 313603005691 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 313603005692 trimer interface [polypeptide binding]; other site 313603005693 dimer interface [polypeptide binding]; other site 313603005694 putative active site [active] 313603005695 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 313603005696 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 313603005697 GTP binding site; other site 313603005698 hypothetical protein; Validated; Region: PRK07411 313603005699 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 313603005700 ATP binding site [chemical binding]; other site 313603005701 substrate interface [chemical binding]; other site 313603005702 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603005703 active site residue [active] 313603005704 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 313603005705 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 313603005706 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 313603005707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603005708 catalytic residue [active] 313603005709 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 313603005710 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 313603005711 dimer interface [polypeptide binding]; other site 313603005712 putative functional site; other site 313603005713 putative MPT binding site; other site 313603005714 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 313603005715 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 313603005716 Methyltransferase domain; Region: Methyltransf_23; pfam13489 313603005717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603005718 S-adenosylmethionine binding site [chemical binding]; other site 313603005719 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 313603005720 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 313603005721 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 313603005722 putative catalytic site [active] 313603005723 putative metal binding site [ion binding]; other site 313603005724 putative phosphate binding site [ion binding]; other site 313603005725 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 313603005726 putative catalytic site [active] 313603005727 putative metal binding site [ion binding]; other site 313603005728 putative phosphate binding site [ion binding]; other site 313603005729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603005730 putative substrate translocation pore; other site 313603005731 Major Facilitator Superfamily; Region: MFS_1; pfam07690 313603005732 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 313603005733 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 313603005734 active site 313603005735 Arylesterase; Region: Arylesterase; pfam01731 313603005736 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 313603005737 GTPase RsgA; Reviewed; Region: PRK01889 313603005738 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 313603005739 RNA binding site [nucleotide binding]; other site 313603005740 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 313603005741 GTPase/Zn-binding domain interface [polypeptide binding]; other site 313603005742 GTP/Mg2+ binding site [chemical binding]; other site 313603005743 G4 box; other site 313603005744 G5 box; other site 313603005745 G1 box; other site 313603005746 Switch I region; other site 313603005747 G2 box; other site 313603005748 G3 box; other site 313603005749 Switch II region; other site 313603005750 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603005751 Sulfatase; Region: Sulfatase; cl17466 313603005752 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 313603005753 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 313603005754 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 313603005755 tetramer interface [polypeptide binding]; other site 313603005756 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 313603005757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603005758 catalytic residue [active] 313603005759 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603005760 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603005761 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 313603005762 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 313603005763 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 313603005764 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 313603005765 TPR repeat; Region: TPR_11; pfam13414 313603005766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 313603005767 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 313603005768 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 313603005769 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603005770 Amidohydrolase; Region: Amidohydro_4; pfam13147 313603005771 active site 313603005772 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 313603005773 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603005774 active site 313603005775 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 313603005776 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 313603005777 active site 313603005778 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 313603005779 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 313603005780 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 313603005781 metal binding site [ion binding]; metal-binding site 313603005782 dimer interface [polypeptide binding]; other site 313603005783 FOG: CBS domain [General function prediction only]; Region: COG0517 313603005784 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 313603005785 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 313603005786 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 313603005787 active site 313603005788 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 313603005789 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 313603005790 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 313603005791 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 313603005792 DHH family; Region: DHH; pfam01368 313603005793 DHHA1 domain; Region: DHHA1; pfam02272 313603005794 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 313603005795 active site 313603005796 multimer interface [polypeptide binding]; other site 313603005797 Protein of unknown function (DUF721); Region: DUF721; pfam05258 313603005798 recombination protein F; Reviewed; Region: recF; PRK00064 313603005799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 313603005800 Walker A/P-loop; other site 313603005801 ATP binding site [chemical binding]; other site 313603005802 Q-loop/lid; other site 313603005803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 313603005804 ABC transporter signature motif; other site 313603005805 Walker B; other site 313603005806 D-loop; other site 313603005807 H-loop/switch region; other site 313603005808 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 313603005809 homopentamer interface [polypeptide binding]; other site 313603005810 active site 313603005811 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 313603005812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603005813 ATP binding site [chemical binding]; other site 313603005814 Mg2+ binding site [ion binding]; other site 313603005815 G-X-G motif; other site 313603005816 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 313603005817 ATP binding site [chemical binding]; other site 313603005818 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 313603005819 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 313603005820 Rhomboid family; Region: Rhomboid; pfam01694 313603005821 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 313603005822 putative catalytic site [active] 313603005823 putative metal binding site [ion binding]; other site 313603005824 putative phosphate binding site [ion binding]; other site 313603005825 WbqC-like protein family; Region: WbqC; pfam08889 313603005826 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 313603005827 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 313603005828 Catalytic site [active] 313603005829 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 313603005830 dihydrodipicolinate reductase; Provisional; Region: PRK00048 313603005831 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 313603005832 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 313603005833 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 313603005834 ParB-like nuclease domain; Region: ParBc; pfam02195 313603005835 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 313603005836 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 313603005837 P-loop; other site 313603005838 Magnesium ion binding site [ion binding]; other site 313603005839 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 313603005840 Magnesium ion binding site [ion binding]; other site 313603005841 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 313603005842 heterodimer interface [polypeptide binding]; other site 313603005843 substrate interaction site [chemical binding]; other site 313603005844 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 313603005845 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 313603005846 ATP-binding site [chemical binding]; other site 313603005847 Sugar specificity; other site 313603005848 Pyrimidine base specificity; other site 313603005849 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 313603005850 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 313603005851 dimer interface [polypeptide binding]; other site 313603005852 substrate binding site [chemical binding]; other site 313603005853 metal binding site [ion binding]; metal-binding site 313603005854 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 313603005855 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 313603005856 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 313603005857 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 313603005858 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 313603005859 carboxyltransferase (CT) interaction site; other site 313603005860 biotinylation site [posttranslational modification]; other site 313603005861 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 313603005862 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 313603005863 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 313603005864 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 313603005865 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 313603005866 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 313603005867 heterodimer interface [polypeptide binding]; other site 313603005868 substrate interaction site [chemical binding]; other site 313603005869 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 313603005870 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 313603005871 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 313603005872 active site 313603005873 substrate binding site [chemical binding]; other site 313603005874 coenzyme B12 binding site [chemical binding]; other site 313603005875 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 313603005876 B12 binding site [chemical binding]; other site 313603005877 cobalt ligand [ion binding]; other site 313603005878 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 313603005879 membrane ATPase/protein kinase; Provisional; Region: PRK09435 313603005880 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 313603005881 Walker A; other site 313603005882 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 313603005883 carboxyltransferase (CT) interaction site; other site 313603005884 biotinylation site [posttranslational modification]; other site 313603005885 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 313603005886 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 313603005887 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 313603005888 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 313603005889 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 313603005890 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 313603005891 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 313603005892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603005893 putative substrate translocation pore; other site 313603005894 acetyl-CoA synthetase; Provisional; Region: PRK00174 313603005895 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 313603005896 active site 313603005897 CoA binding site [chemical binding]; other site 313603005898 acyl-activating enzyme (AAE) consensus motif; other site 313603005899 AMP binding site [chemical binding]; other site 313603005900 acetate binding site [chemical binding]; other site 313603005901 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 313603005902 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 313603005903 Na binding site [ion binding]; other site 313603005904 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 313603005905 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 313603005906 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 313603005907 ligand binding site [chemical binding]; other site 313603005908 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 313603005909 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 313603005910 metal binding triad; other site 313603005911 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 313603005912 active site 313603005913 catalytic site [active] 313603005914 substrate binding site [chemical binding]; other site 313603005915 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 313603005916 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603005917 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603005918 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 313603005919 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 313603005920 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 313603005921 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 313603005922 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 313603005923 active site 313603005924 trimer interface [polypeptide binding]; other site 313603005925 allosteric site; other site 313603005926 active site lid [active] 313603005927 hexamer (dimer of trimers) interface [polypeptide binding]; other site 313603005928 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 313603005929 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 313603005930 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 313603005931 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 313603005932 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 313603005933 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 313603005934 putative active site [active] 313603005935 Cytochrome c; Region: Cytochrom_C; pfam00034 313603005936 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 313603005937 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 313603005938 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 313603005939 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 313603005940 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 313603005941 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 313603005942 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 313603005943 Sulfatase; Region: Sulfatase; cl17466 313603005944 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603005945 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 313603005946 Domain of unknown function DUF20; Region: UPF0118; pfam01594 313603005947 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 313603005948 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 313603005949 RNA methyltransferase, RsmE family; Region: TIGR00046 313603005950 TfoX N-terminal domain; Region: TfoX_N; cl17592 313603005951 UGMP family protein; Validated; Region: PRK09604 313603005952 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 313603005953 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 313603005954 Family of unknown function (DUF490); Region: DUF490; pfam04357 313603005955 6-phosphofructokinase; Provisional; Region: PRK03202 313603005956 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 313603005957 active site 313603005958 ADP/pyrophosphate binding site [chemical binding]; other site 313603005959 dimerization interface [polypeptide binding]; other site 313603005960 allosteric effector site; other site 313603005961 fructose-1,6-bisphosphate binding site; other site 313603005962 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 313603005963 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 313603005964 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 313603005965 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 313603005966 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 313603005967 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 313603005968 mce related protein; Region: MCE; pfam02470 313603005969 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 313603005970 4Fe-4S binding domain; Region: Fer4; cl02805 313603005971 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 313603005972 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 313603005973 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 313603005974 Cysteine-rich domain; Region: CCG; pfam02754 313603005975 Cysteine-rich domain; Region: CCG; pfam02754 313603005976 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 313603005977 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 313603005978 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603005979 Beta-lactamase; Region: Beta-lactamase; cl17358 313603005980 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 313603005981 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 313603005982 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 313603005983 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 313603005984 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 313603005985 ligand binding site [chemical binding]; other site 313603005986 Bacterial sugar transferase; Region: Bac_transf; pfam02397 313603005987 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 313603005988 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 313603005989 putative ADP-binding pocket [chemical binding]; other site 313603005990 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929 313603005991 putative active site [active] 313603005992 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 313603005993 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 313603005994 putative active site [active] 313603005995 putative cosubstrate binding site; other site 313603005996 putative substrate binding site [chemical binding]; other site 313603005997 catalytic site [active] 313603005998 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 313603005999 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 313603006000 putative ADP-binding pocket [chemical binding]; other site 313603006001 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 313603006002 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 313603006003 putative ADP-binding pocket [chemical binding]; other site 313603006004 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 313603006005 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 313603006006 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 313603006007 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 313603006008 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 313603006009 trimer interface [polypeptide binding]; other site 313603006010 active site 313603006011 substrate binding site [chemical binding]; other site 313603006012 CoA binding site [chemical binding]; other site 313603006013 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 313603006014 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 313603006015 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 313603006016 putative ADP-binding pocket [chemical binding]; other site 313603006017 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 313603006018 Pectate lyase; Region: Pec_lyase_C; cl01593 313603006019 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 313603006020 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 313603006021 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 313603006022 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 313603006023 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 313603006024 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 313603006025 NAD binding site [chemical binding]; other site 313603006026 substrate binding site [chemical binding]; other site 313603006027 homodimer interface [polypeptide binding]; other site 313603006028 active site 313603006029 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 313603006030 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 313603006031 putative NAD(P) binding site [chemical binding]; other site 313603006032 active site 313603006033 putative substrate binding site [chemical binding]; other site 313603006034 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 313603006035 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 313603006036 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 313603006037 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 313603006038 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 313603006039 inhibitor-cofactor binding pocket; inhibition site 313603006040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603006041 catalytic residue [active] 313603006042 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 313603006043 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 313603006044 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 313603006045 NAD(P) binding site [chemical binding]; other site 313603006046 homodimer interface [polypeptide binding]; other site 313603006047 substrate binding site [chemical binding]; other site 313603006048 active site 313603006049 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 313603006050 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 313603006051 Chain length determinant protein; Region: Wzz; cl15801 313603006052 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 313603006053 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 313603006054 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 313603006055 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 313603006056 short chain dehydrogenase; Provisional; Region: PRK06198 313603006057 classical (c) SDRs; Region: SDR_c; cd05233 313603006058 NAD(P) binding site [chemical binding]; other site 313603006059 active site 313603006060 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 313603006061 Strictosidine synthase; Region: Str_synth; pfam03088 313603006062 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 313603006063 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 313603006064 active site 313603006065 extended (e) SDRs; Region: SDR_e; cd08946 313603006066 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 313603006067 NAD(P) binding site [chemical binding]; other site 313603006068 active site 313603006069 substrate binding site [chemical binding]; other site 313603006070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603006071 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 313603006072 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 313603006073 NAD binding site [chemical binding]; other site 313603006074 homotetramer interface [polypeptide binding]; other site 313603006075 homodimer interface [polypeptide binding]; other site 313603006076 substrate binding site [chemical binding]; other site 313603006077 active site 313603006078 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 313603006079 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 313603006080 substrate binding site; other site 313603006081 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 313603006082 ATP-grasp domain; Region: ATP-grasp_4; cl17255 313603006083 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 313603006084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603006085 NAD(P) binding site [chemical binding]; other site 313603006086 active site 313603006087 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 313603006088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603006089 NAD(P) binding site [chemical binding]; other site 313603006090 active site 313603006091 putative glycosyl transferase; Provisional; Region: PRK10073 313603006092 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 313603006093 active site 313603006094 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 313603006095 Putative Ig domain; Region: He_PIG; pfam05345 313603006096 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 313603006097 Kelch motif; Region: Kelch_6; pfam13964 313603006098 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 313603006099 Kelch motif; Region: Kelch_1; pfam01344 313603006100 FOG: PKD repeat [General function prediction only]; Region: COG3291 313603006101 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 313603006102 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 313603006103 FOG: PKD repeat [General function prediction only]; Region: COG3291 313603006104 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 313603006105 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 313603006106 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 313603006107 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 313603006108 kelch-like protein; Provisional; Region: PHA03098 313603006109 Kelch domain; Region: Kelch; smart00612 313603006110 Kelch motif; Region: Kelch_1; pfam01344 313603006111 Kelch motif; Region: Kelch_1; pfam01344 313603006112 Fn3 associated; Region: Fn3_assoc; pfam13287 313603006113 CotH protein; Region: CotH; pfam08757 313603006114 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 313603006115 Lamin Tail Domain; Region: LTD; pfam00932 313603006116 Lamin Tail Domain; Region: LTD; pfam00932 313603006117 Lamin Tail Domain; Region: LTD; pfam00932 313603006118 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 313603006119 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 313603006120 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 313603006121 pyruvate phosphate dikinase; Provisional; Region: PRK09279 313603006122 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 313603006123 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 313603006124 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 313603006125 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 313603006126 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB [Energy production and conversion]; Region: COG2878 313603006127 Putative Fe-S cluster; Region: FeS; cl17515 313603006128 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 313603006129 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 313603006130 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 313603006131 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 313603006132 SLBB domain; Region: SLBB; pfam10531 313603006133 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 313603006134 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 313603006135 FMN-binding domain; Region: FMN_bind; cl01081 313603006136 electron transport complex RsxE subunit; Provisional; Region: PRK12405 313603006137 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 313603006138 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 313603006139 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 313603006140 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 313603006141 trmE is a tRNA modification GTPase; Region: trmE; cd04164 313603006142 G1 box; other site 313603006143 GTP/Mg2+ binding site [chemical binding]; other site 313603006144 Switch I region; other site 313603006145 G2 box; other site 313603006146 Switch II region; other site 313603006147 G3 box; other site 313603006148 G4 box; other site 313603006149 G5 box; other site 313603006150 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 313603006151 Tic20-like protein; Region: Tic20; pfam09685 313603006152 DNA polymerase III subunit beta; Validated; Region: PRK05643 313603006153 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 313603006154 putative DNA binding surface [nucleotide binding]; other site 313603006155 dimer interface [polypeptide binding]; other site 313603006156 beta-clamp/clamp loader binding surface; other site 313603006157 beta-clamp/translesion DNA polymerase binding surface; other site 313603006158 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 313603006159 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 313603006160 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 313603006161 PhoH-like protein; Region: PhoH; pfam02562 313603006162 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 313603006163 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 313603006164 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 313603006165 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 313603006166 Cytochrome c; Region: Cytochrom_C; pfam00034 313603006167 Methane oxygenase PmoA; Region: PmoA; pfam14100 313603006168 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 313603006169 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 313603006170 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 313603006171 ligand binding site [chemical binding]; other site 313603006172 flexible hinge region; other site 313603006173 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 313603006174 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 313603006175 active site 313603006176 metal binding site [ion binding]; metal-binding site 313603006177 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 313603006178 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 313603006179 ligand binding site [chemical binding]; other site 313603006180 flexible hinge region; other site 313603006181 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 313603006182 cyclase homology domain; Region: CHD; cd07302 313603006183 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 313603006184 nucleotidyl binding site; other site 313603006185 metal binding site [ion binding]; metal-binding site 313603006186 dimer interface [polypeptide binding]; other site 313603006187 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603006188 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603006189 Amidohydrolase; Region: Amidohydro_4; pfam13147 313603006190 active site 313603006191 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 313603006192 cyclase homology domain; Region: CHD; cd07302 313603006193 nucleotidyl binding site; other site 313603006194 metal binding site [ion binding]; metal-binding site 313603006195 dimer interface [polypeptide binding]; other site 313603006196 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 313603006197 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 313603006198 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 313603006199 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 313603006200 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 313603006201 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 313603006202 Peptidase family M23; Region: Peptidase_M23; pfam01551 313603006203 Erythromycin esterase; Region: Erythro_esteras; pfam05139 313603006204 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 313603006205 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 313603006206 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 313603006207 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 313603006208 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603006209 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603006210 integron integrase; Region: integrase_gron; TIGR02249 313603006211 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 313603006212 active site 313603006213 DNA binding site [nucleotide binding] 313603006214 Int/Topo IB signature motif; other site 313603006215 Uncharacterized protein containing a Zn-ribbon (DUF2116); Region: DUF2116; cl01683 313603006216 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 313603006217 hydrophobic ligand binding site; other site 313603006218 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 313603006219 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 313603006220 homodimer interface [polypeptide binding]; other site 313603006221 substrate-cofactor binding pocket; other site 313603006222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603006223 catalytic residue [active] 313603006224 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 313603006225 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 313603006226 IHF - DNA interface [nucleotide binding]; other site 313603006227 IHF dimer interface [polypeptide binding]; other site 313603006228 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 313603006229 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 313603006230 putative active site [active] 313603006231 substrate binding site [chemical binding]; other site 313603006232 putative cosubstrate binding site; other site 313603006233 catalytic site [active] 313603006234 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 313603006235 substrate binding site [chemical binding]; other site 313603006236 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 313603006237 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 313603006238 ATP binding site [chemical binding]; other site 313603006239 putative Mg++ binding site [ion binding]; other site 313603006240 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 313603006241 nucleotide binding region [chemical binding]; other site 313603006242 ATP-binding site [chemical binding]; other site 313603006243 Predicted ATPase [General function prediction only]; Region: COG3911 313603006244 AAA domain; Region: AAA_28; pfam13521 313603006245 Protein of unknown function (DUF493); Region: DUF493; pfam04359 313603006246 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 313603006247 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 313603006248 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 313603006249 hinge; other site 313603006250 active site 313603006251 YhhN-like protein; Region: YhhN; pfam07947 313603006252 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 313603006253 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 313603006254 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 313603006255 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 313603006256 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 313603006257 putative metal binding site [ion binding]; other site 313603006258 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 313603006259 DNA photolyase; Region: DNA_photolyase; pfam00875 313603006260 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 313603006261 putative hydrophobic ligand binding site [chemical binding]; other site 313603006262 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 313603006263 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 313603006264 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 313603006265 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 313603006266 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 313603006267 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 313603006268 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 313603006269 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 313603006270 starch binding outer membrane protein SusD; Region: SusD; cl17845 313603006271 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 313603006272 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603006273 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603006274 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 313603006275 DNA binding site [nucleotide binding] 313603006276 domain linker motif; other site 313603006277 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 313603006278 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 313603006279 ligand binding site [chemical binding]; other site 313603006280 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 313603006281 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 313603006282 Na binding site [ion binding]; other site 313603006283 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 313603006284 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 313603006285 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 313603006286 Mechanosensitive ion channel; Region: MS_channel; pfam00924 313603006287 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 313603006288 active site 313603006289 dimer interface [polypeptide binding]; other site 313603006290 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 313603006291 RNA polymerase sigma factor; Provisional; Region: PRK11922 313603006292 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603006293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603006294 DNA binding residues [nucleotide binding] 313603006295 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 313603006296 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 313603006297 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 313603006298 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 313603006299 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 313603006300 HlyD family secretion protein; Region: HlyD_3; pfam13437 313603006301 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 313603006302 Protein export membrane protein; Region: SecD_SecF; cl14618 313603006303 Protein export membrane protein; Region: SecD_SecF; cl14618 313603006304 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 313603006305 cyclase homology domain; Region: CHD; cd07302 313603006306 nucleotidyl binding site; other site 313603006307 metal binding site [ion binding]; metal-binding site 313603006308 dimer interface [polypeptide binding]; other site 313603006309 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 313603006310 arsenical-resistance protein; Region: acr3; TIGR00832 313603006311 Low molecular weight phosphatase family; Region: LMWPc; cl00105 313603006312 active site 313603006313 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 313603006314 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 313603006315 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 313603006316 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 313603006317 homodimer interface [polypeptide binding]; other site 313603006318 substrate-cofactor binding pocket; other site 313603006319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603006320 catalytic residue [active] 313603006321 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 313603006322 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603006323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603006324 binding surface 313603006325 TPR motif; other site 313603006326 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603006327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603006328 binding surface 313603006329 TPR motif; other site 313603006330 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 313603006331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 313603006332 dimer interface [polypeptide binding]; other site 313603006333 phosphorylation site [posttranslational modification] 313603006334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603006335 ATP binding site [chemical binding]; other site 313603006336 Mg2+ binding site [ion binding]; other site 313603006337 G-X-G motif; other site 313603006338 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 313603006339 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 313603006340 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 313603006341 Peptidase family M28; Region: Peptidase_M28; pfam04389 313603006342 metal binding site [ion binding]; metal-binding site 313603006343 Cupin domain; Region: Cupin_2; pfam07883 313603006344 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 313603006345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603006346 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 313603006347 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 313603006348 inhibitor site; inhibition site 313603006349 active site 313603006350 dimer interface [polypeptide binding]; other site 313603006351 catalytic residue [active] 313603006352 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 313603006353 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 313603006354 dimer interface [polypeptide binding]; other site 313603006355 NADP binding site [chemical binding]; other site 313603006356 catalytic residues [active] 313603006357 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 313603006358 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 313603006359 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 313603006360 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 313603006361 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 313603006362 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 313603006363 HlyD family secretion protein; Region: HlyD_3; pfam13437 313603006364 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 313603006365 Outer membrane efflux protein; Region: OEP; pfam02321 313603006366 Sulfatase; Region: Sulfatase; cl17466 313603006367 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603006368 Glucuronate isomerase; Region: UxaC; pfam02614 313603006369 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 313603006370 mannonate dehydratase; Provisional; Region: PRK03906 313603006371 mannonate dehydratase; Region: uxuA; TIGR00695 313603006372 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 313603006373 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603006374 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603006375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 313603006376 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 313603006377 active site 313603006378 catalytic triad [active] 313603006379 oxyanion hole [active] 313603006380 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 313603006381 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 313603006382 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 313603006383 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 313603006384 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 313603006385 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 313603006386 Walker A/P-loop; other site 313603006387 ATP binding site [chemical binding]; other site 313603006388 Q-loop/lid; other site 313603006389 ABC transporter signature motif; other site 313603006390 Walker B; other site 313603006391 D-loop; other site 313603006392 H-loop/switch region; other site 313603006393 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 313603006394 GTP cyclohydrolase I; Provisional; Region: PLN03044 313603006395 homodecamer interface [polypeptide binding]; other site 313603006396 active site 313603006397 putative catalytic site residues [active] 313603006398 zinc binding site [ion binding]; other site 313603006399 GTP-CH-I/GFRP interaction surface; other site 313603006400 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603006401 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 313603006402 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 313603006403 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603006404 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 313603006405 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 313603006406 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 313603006407 putative ligand binding site [chemical binding]; other site 313603006408 NAD binding site [chemical binding]; other site 313603006409 dimerization interface [polypeptide binding]; other site 313603006410 catalytic site [active] 313603006411 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 313603006412 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603006413 catalytic residue [active] 313603006414 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 313603006415 NAD(P) binding site [chemical binding]; other site 313603006416 catalytic residues [active] 313603006417 4Fe-4S binding domain; Region: Fer4; pfam00037 313603006418 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 313603006419 agmatinase; Region: agmatinase; TIGR01230 313603006420 putative active site [active] 313603006421 Mn binding site [ion binding]; other site 313603006422 GTP-binding protein YchF; Reviewed; Region: PRK09601 313603006423 YchF GTPase; Region: YchF; cd01900 313603006424 G1 box; other site 313603006425 GTP/Mg2+ binding site [chemical binding]; other site 313603006426 Switch I region; other site 313603006427 G2 box; other site 313603006428 Switch II region; other site 313603006429 G3 box; other site 313603006430 G4 box; other site 313603006431 G5 box; other site 313603006432 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 313603006433 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 313603006434 EamA-like transporter family; Region: EamA; pfam00892 313603006435 EamA-like transporter family; Region: EamA; pfam00892 313603006436 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 313603006437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603006438 ATP binding site [chemical binding]; other site 313603006439 Mg2+ binding site [ion binding]; other site 313603006440 G-X-G motif; other site 313603006441 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 313603006442 ATP binding site [chemical binding]; other site 313603006443 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 313603006444 active site 313603006445 putative metal-binding site [ion binding]; other site 313603006446 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 313603006447 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 313603006448 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 313603006449 CAP-like domain; other site 313603006450 active site 313603006451 primary dimer interface [polypeptide binding]; other site 313603006452 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 313603006453 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 313603006454 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 313603006455 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 313603006456 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 313603006457 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 313603006458 non-specific DNA binding site [nucleotide binding]; other site 313603006459 salt bridge; other site 313603006460 sequence-specific DNA binding site [nucleotide binding]; other site 313603006461 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 313603006462 putative active site [active] 313603006463 Zn binding site [ion binding]; other site 313603006464 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 313603006465 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 313603006466 putative DNA binding site [nucleotide binding]; other site 313603006467 putative Zn2+ binding site [ion binding]; other site 313603006468 AsnC family; Region: AsnC_trans_reg; pfam01037 313603006469 DinB superfamily; Region: DinB_2; pfam12867 313603006470 DinB family; Region: DinB; cl17821 313603006471 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 313603006472 active site 313603006473 dimer interface [polypeptide binding]; other site 313603006474 metal binding site [ion binding]; metal-binding site 313603006475 Proline dehydrogenase; Region: Pro_dh; cl03282 313603006476 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 313603006477 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 313603006478 hexamer interface [polypeptide binding]; other site 313603006479 ligand binding site [chemical binding]; other site 313603006480 putative active site [active] 313603006481 NAD(P) binding site [chemical binding]; other site 313603006482 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 313603006483 Response regulator receiver domain; Region: Response_reg; pfam00072 313603006484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603006485 active site 313603006486 phosphorylation site [posttranslational modification] 313603006487 intermolecular recognition site; other site 313603006488 dimerization interface [polypeptide binding]; other site 313603006489 PglZ domain; Region: PglZ; pfam08665 313603006490 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 313603006491 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 313603006492 Zn2+ binding site [ion binding]; other site 313603006493 Mg2+ binding site [ion binding]; other site 313603006494 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 313603006495 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 313603006496 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 313603006497 trimer interface [polypeptide binding]; other site 313603006498 active site 313603006499 UDP-GlcNAc binding site [chemical binding]; other site 313603006500 lipid binding site [chemical binding]; lipid-binding site 313603006501 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 313603006502 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 313603006503 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 313603006504 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 313603006505 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 313603006506 active site 313603006507 elongation factor P; Validated; Region: PRK00529 313603006508 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 313603006509 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 313603006510 RNA binding site [nucleotide binding]; other site 313603006511 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 313603006512 RNA binding site [nucleotide binding]; other site 313603006513 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 313603006514 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 313603006515 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 313603006516 trimer interface [polypeptide binding]; other site 313603006517 active site 313603006518 UDP-GlcNAc binding site [chemical binding]; other site 313603006519 lipid binding site [chemical binding]; lipid-binding site 313603006520 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 313603006521 CoA binding domain; Region: CoA_binding; smart00881 313603006522 CoA-ligase; Region: Ligase_CoA; pfam00549 313603006523 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 313603006524 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 313603006525 NAD(P) binding site [chemical binding]; other site 313603006526 homotetramer interface [polypeptide binding]; other site 313603006527 homodimer interface [polypeptide binding]; other site 313603006528 active site 313603006529 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 313603006530 metal ion-dependent adhesion site (MIDAS); other site 313603006531 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 313603006532 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 313603006533 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 313603006534 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 313603006535 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 313603006536 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 313603006537 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 313603006538 histidinol dehydrogenase; Region: hisD; TIGR00069 313603006539 NAD binding site [chemical binding]; other site 313603006540 dimerization interface [polypeptide binding]; other site 313603006541 product binding site; other site 313603006542 substrate binding site [chemical binding]; other site 313603006543 zinc binding site [ion binding]; other site 313603006544 catalytic residues [active] 313603006545 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 313603006546 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 313603006547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603006548 homodimer interface [polypeptide binding]; other site 313603006549 catalytic residue [active] 313603006550 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 313603006551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 313603006552 active site 313603006553 motif I; other site 313603006554 motif II; other site 313603006555 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 313603006556 putative active site pocket [active] 313603006557 4-fold oligomerization interface [polypeptide binding]; other site 313603006558 metal binding residues [ion binding]; metal-binding site 313603006559 3-fold/trimer interface [polypeptide binding]; other site 313603006560 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 313603006561 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 313603006562 putative active site [active] 313603006563 oxyanion strand; other site 313603006564 catalytic triad [active] 313603006565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603006566 Coenzyme A binding pocket [chemical binding]; other site 313603006567 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 313603006568 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 313603006569 catalytic residues [active] 313603006570 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 313603006571 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 313603006572 substrate binding site [chemical binding]; other site 313603006573 glutamase interaction surface [polypeptide binding]; other site 313603006574 aspartate racemase; Region: asp_race; TIGR00035 313603006575 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 313603006576 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 313603006577 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 313603006578 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 313603006579 metal binding site [ion binding]; metal-binding site 313603006580 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 313603006581 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 313603006582 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603006583 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603006584 DNA binding residues [nucleotide binding] 313603006585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603006586 NADH(P)-binding; Region: NAD_binding_10; pfam13460 313603006587 NAD(P) binding site [chemical binding]; other site 313603006588 active site 313603006589 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 313603006590 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603006591 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 313603006592 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603006593 DNA binding residues [nucleotide binding] 313603006594 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 313603006595 dimerization interface [polypeptide binding]; other site 313603006596 Transcriptional regulators [Transcription]; Region: MarR; COG1846 313603006597 putative DNA binding site [nucleotide binding]; other site 313603006598 putative Zn2+ binding site [ion binding]; other site 313603006599 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 313603006600 EthD domain; Region: EthD; cl17553 313603006601 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 313603006602 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 313603006603 conserved cys residue [active] 313603006604 CAAX protease self-immunity; Region: Abi; pfam02517 313603006605 LytTr DNA-binding domain; Region: LytTR; smart00850 313603006606 short chain dehydrogenase; Provisional; Region: PRK12746 313603006607 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 313603006608 NADP binding site [chemical binding]; other site 313603006609 active site 313603006610 steroid binding site; other site 313603006611 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603006612 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603006613 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 313603006614 HEPN domain; Region: HEPN; cl00824 313603006615 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603006616 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 313603006617 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603006618 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 313603006619 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 313603006620 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 313603006621 metal ion-dependent adhesion site (MIDAS); other site 313603006622 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 313603006623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 313603006624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 313603006625 dimerization interface [polypeptide binding]; other site 313603006626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 313603006627 dimer interface [polypeptide binding]; other site 313603006628 phosphorylation site [posttranslational modification] 313603006629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603006630 ATP binding site [chemical binding]; other site 313603006631 Mg2+ binding site [ion binding]; other site 313603006632 G-X-G motif; other site 313603006633 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 313603006634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603006635 active site 313603006636 phosphorylation site [posttranslational modification] 313603006637 intermolecular recognition site; other site 313603006638 dimerization interface [polypeptide binding]; other site 313603006639 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 313603006640 DNA binding site [nucleotide binding] 313603006641 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 313603006642 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 313603006643 active site 313603006644 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 313603006645 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 313603006646 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 313603006647 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 313603006648 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 313603006649 TAP-like protein; Region: Abhydrolase_4; pfam08386 313603006650 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 313603006651 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 313603006652 dimer interface [polypeptide binding]; other site 313603006653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603006654 catalytic residue [active] 313603006655 serine O-acetyltransferase; Region: cysE; TIGR01172 313603006656 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 313603006657 trimer interface [polypeptide binding]; other site 313603006658 active site 313603006659 substrate binding site [chemical binding]; other site 313603006660 CoA binding site [chemical binding]; other site 313603006661 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 313603006662 Protein of unknown function DUF72; Region: DUF72; pfam01904 313603006663 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 313603006664 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 313603006665 active site 313603006666 dimer interface [polypeptide binding]; other site 313603006667 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603006668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 313603006669 dimer interface [polypeptide binding]; other site 313603006670 phosphorylation site [posttranslational modification] 313603006671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603006672 ATP binding site [chemical binding]; other site 313603006673 Mg2+ binding site [ion binding]; other site 313603006674 G-X-G motif; other site 313603006675 Response regulator receiver domain; Region: Response_reg; pfam00072 313603006676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603006677 active site 313603006678 phosphorylation site [posttranslational modification] 313603006679 intermolecular recognition site; other site 313603006680 dimerization interface [polypeptide binding]; other site 313603006681 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 313603006682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603006683 active site 313603006684 phosphorylation site [posttranslational modification] 313603006685 intermolecular recognition site; other site 313603006686 dimerization interface [polypeptide binding]; other site 313603006687 HEAT repeats; Region: HEAT_2; pfam13646 313603006688 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 313603006689 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 313603006690 DXD motif; other site 313603006691 Sulfatase; Region: Sulfatase; cl17466 313603006692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603006693 TPR motif; other site 313603006694 binding surface 313603006695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603006696 binding surface 313603006697 TPR motif; other site 313603006698 Tetratricopeptide repeat; Region: TPR_16; pfam13432 313603006699 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 313603006700 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 313603006701 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603006702 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 313603006703 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603006704 DNA binding residues [nucleotide binding] 313603006705 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 313603006706 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 313603006707 putative ligand binding site [chemical binding]; other site 313603006708 NAD binding site [chemical binding]; other site 313603006709 dimerization interface [polypeptide binding]; other site 313603006710 catalytic site [active] 313603006711 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 313603006712 ATP binding site [chemical binding]; other site 313603006713 putative Mg++ binding site [ion binding]; other site 313603006714 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 313603006715 nucleotide binding region [chemical binding]; other site 313603006716 ATP-binding site [chemical binding]; other site 313603006717 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 313603006718 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 313603006719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 313603006720 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 313603006721 Methyltransferase domain; Region: Methyltransf_31; pfam13847 313603006722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603006723 S-adenosylmethionine binding site [chemical binding]; other site 313603006724 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 313603006725 dimerization interface [polypeptide binding]; other site 313603006726 putative DNA binding site [nucleotide binding]; other site 313603006727 putative Zn2+ binding site [ion binding]; other site 313603006728 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 313603006729 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 313603006730 substrate binding [chemical binding]; other site 313603006731 active site 313603006732 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 313603006733 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 313603006734 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 313603006735 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 313603006736 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 313603006737 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 313603006738 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 313603006739 SnoaL-like domain; Region: SnoaL_2; pfam12680 313603006740 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 313603006741 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 313603006742 active site 313603006743 YWTD domain; Region: YWTD; pfam13570 313603006744 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 313603006745 active site 313603006746 FOG: WD40-like repeat [Function unknown]; Region: COG1520 313603006747 Trp docking motif [polypeptide binding]; other site 313603006748 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 313603006749 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 313603006750 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 313603006751 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 313603006752 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 313603006753 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 313603006754 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 313603006755 substrate binding site [chemical binding]; other site 313603006756 oxyanion hole (OAH) forming residues; other site 313603006757 trimer interface [polypeptide binding]; other site 313603006758 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603006759 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603006760 3D domain; Region: 3D; cl01439 313603006761 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 313603006762 amidase catalytic site [active] 313603006763 Zn binding residues [ion binding]; other site 313603006764 substrate binding site [chemical binding]; other site 313603006765 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 313603006766 putative active site [active] 313603006767 Zn binding site [ion binding]; other site 313603006768 von Willebrand factor type A domain; Region: VWA_2; pfam13519 313603006769 metal ion-dependent adhesion site (MIDAS); other site 313603006770 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 313603006771 XdhC Rossmann domain; Region: XdhC_C; pfam13478 313603006772 Amidohydrolase; Region: Amidohydro_2; pfam04909 313603006773 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 313603006774 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603006775 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603006776 DNA binding residues [nucleotide binding] 313603006777 Transcriptional regulators [Transcription]; Region: GntR; COG1802 313603006778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 313603006779 DNA-binding site [nucleotide binding]; DNA binding site 313603006780 FCD domain; Region: FCD; pfam07729 313603006781 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 313603006782 putative ligand binding site [chemical binding]; other site 313603006783 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 313603006784 putative metal binding residues [ion binding]; other site 313603006785 signature motif; other site 313603006786 dimer interface [polypeptide binding]; other site 313603006787 active site 313603006788 polyP binding site; other site 313603006789 substrate binding site [chemical binding]; other site 313603006790 acceptor-phosphate pocket; other site 313603006791 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 313603006792 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 313603006793 elongation factor G; Reviewed; Region: PRK12740 313603006794 G1 box; other site 313603006795 putative GEF interaction site [polypeptide binding]; other site 313603006796 GTP/Mg2+ binding site [chemical binding]; other site 313603006797 Switch I region; other site 313603006798 G2 box; other site 313603006799 G3 box; other site 313603006800 Switch II region; other site 313603006801 G4 box; other site 313603006802 G5 box; other site 313603006803 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 313603006804 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 313603006805 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 313603006806 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; pfam09579 313603006807 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 313603006808 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603006809 active site residue [active] 313603006810 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603006811 active site residue [active] 313603006812 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603006813 active site residue [active] 313603006814 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603006815 active site residue [active] 313603006816 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 313603006817 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 313603006818 ligand binding site [chemical binding]; other site 313603006819 flexible hinge region; other site 313603006820 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 313603006821 non-specific DNA interactions [nucleotide binding]; other site 313603006822 DNA binding site [nucleotide binding] 313603006823 sequence specific DNA binding site [nucleotide binding]; other site 313603006824 putative cAMP binding site [chemical binding]; other site 313603006825 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603006826 active site residue [active] 313603006827 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603006828 active site residue [active] 313603006829 Sulphur transport; Region: Sulf_transp; pfam04143 313603006830 Sulphur transport; Region: Sulf_transp; pfam04143 313603006831 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 313603006832 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 313603006833 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 313603006834 thiosulfate reductase PhsA; Provisional; Region: PRK15488 313603006835 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 313603006836 putative [Fe4-S4] binding site [ion binding]; other site 313603006837 putative molybdopterin cofactor binding site [chemical binding]; other site 313603006838 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 313603006839 putative molybdopterin cofactor binding site; other site 313603006840 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 313603006841 DNA-binding site [nucleotide binding]; DNA binding site 313603006842 RNA-binding motif; other site 313603006843 SnoaL-like domain; Region: SnoaL_2; pfam12680 313603006844 SnoaL-like domain; Region: SnoaL_2; pfam12680 313603006845 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 313603006846 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 313603006847 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 313603006848 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 313603006849 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 313603006850 EamA-like transporter family; Region: EamA; pfam00892 313603006851 EamA-like transporter family; Region: EamA; pfam00892 313603006852 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 313603006853 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 313603006854 non-specific DNA interactions [nucleotide binding]; other site 313603006855 DNA binding site [nucleotide binding] 313603006856 sequence specific DNA binding site [nucleotide binding]; other site 313603006857 putative cAMP binding site [chemical binding]; other site 313603006858 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 313603006859 K-Cl cotransporter; Region: 2a30; TIGR00930 313603006860 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 313603006861 pseudouridine synthase; Region: TIGR00093 313603006862 active site 313603006863 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 313603006864 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 313603006865 homodimer interface [polypeptide binding]; other site 313603006866 homotetramer interface [polypeptide binding]; other site 313603006867 active site pocket [active] 313603006868 cleavage site 313603006869 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 313603006870 cyclase homology domain; Region: CHD; cd07302 313603006871 nucleotidyl binding site; other site 313603006872 metal binding site [ion binding]; metal-binding site 313603006873 dimer interface [polypeptide binding]; other site 313603006874 Predicted membrane protein [Function unknown]; Region: COG2311 313603006875 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 313603006876 Protein of unknown function (DUF418); Region: DUF418; pfam04235 313603006877 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 313603006878 VPS10 domain; Region: VPS10; smart00602 313603006879 VPS10 domain; Region: VPS10; smart00602 313603006880 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 313603006881 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 313603006882 putative active site [active] 313603006883 catalytic site [active] 313603006884 Cytochrome c; Region: Cytochrom_C; cl11414 313603006885 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 313603006886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 313603006887 ATP binding site [chemical binding]; other site 313603006888 putative Mg++ binding site [ion binding]; other site 313603006889 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 313603006890 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 313603006891 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 313603006892 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 313603006893 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 313603006894 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 313603006895 metal binding site [ion binding]; metal-binding site 313603006896 Helix-turn-helix domain; Region: HTH_18; pfam12833 313603006897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603006898 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 313603006899 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 313603006900 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 313603006901 active site 313603006902 FMN binding site [chemical binding]; other site 313603006903 2,4-decadienoyl-CoA binding site; other site 313603006904 catalytic residue [active] 313603006905 4Fe-4S cluster binding site [ion binding]; other site 313603006906 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 313603006907 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 313603006908 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 313603006909 alpha-galactosidase; Provisional; Region: PRK15076 313603006910 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 313603006911 NAD binding site [chemical binding]; other site 313603006912 sugar binding site [chemical binding]; other site 313603006913 divalent metal binding site [ion binding]; other site 313603006914 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 313603006915 dimer interface [polypeptide binding]; other site 313603006916 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 313603006917 Na binding site [ion binding]; other site 313603006918 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 313603006919 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 313603006920 active site 313603006921 trimer interface [polypeptide binding]; other site 313603006922 allosteric site; other site 313603006923 active site lid [active] 313603006924 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 313603006925 Helix-turn-helix domain; Region: HTH_18; pfam12833 313603006926 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603006927 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 313603006928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603006929 Coenzyme A binding pocket [chemical binding]; other site 313603006930 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 313603006931 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 313603006932 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 313603006933 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 313603006934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603006935 active site 313603006936 phosphorylation site [posttranslational modification] 313603006937 intermolecular recognition site; other site 313603006938 dimerization interface [polypeptide binding]; other site 313603006939 LytTr DNA-binding domain; Region: LytTR; smart00850 313603006940 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 313603006941 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603006942 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603006943 Histidine kinase; Region: His_kinase; pfam06580 313603006944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 313603006945 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 313603006946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603006947 active site 313603006948 phosphorylation site [posttranslational modification] 313603006949 intermolecular recognition site; other site 313603006950 dimerization interface [polypeptide binding]; other site 313603006951 LytTr DNA-binding domain; Region: LytTR; smart00850 313603006952 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 313603006953 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 313603006954 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 313603006955 Domain of unknown function (DUF955); Region: DUF955; pfam06114 313603006956 DEAD-like helicases superfamily; Region: DEXDc; smart00487 313603006957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 313603006958 ATP binding site [chemical binding]; other site 313603006959 putative Mg++ binding site [ion binding]; other site 313603006960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 313603006961 nucleotide binding region [chemical binding]; other site 313603006962 ATP-binding site [chemical binding]; other site 313603006963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 313603006964 active site 313603006965 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 313603006966 DNA protecting protein DprA; Region: dprA; TIGR00732 313603006967 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 313603006968 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 313603006969 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 313603006970 ligand binding site [chemical binding]; other site 313603006971 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 313603006972 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 313603006973 tetramer interface [polypeptide binding]; other site 313603006974 TPP-binding site [chemical binding]; other site 313603006975 heterodimer interface [polypeptide binding]; other site 313603006976 phosphorylation loop region [posttranslational modification] 313603006977 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 313603006978 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 313603006979 alpha subunit interface [polypeptide binding]; other site 313603006980 TPP binding site [chemical binding]; other site 313603006981 heterodimer interface [polypeptide binding]; other site 313603006982 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 313603006983 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 313603006984 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 313603006985 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 313603006986 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 313603006987 putative rRNA binding site [nucleotide binding]; other site 313603006988 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 313603006989 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 313603006990 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 313603006991 ligand binding site [chemical binding]; other site 313603006992 active site 313603006993 UGI interface [polypeptide binding]; other site 313603006994 catalytic site [active] 313603006995 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 313603006996 putative ligand binding site [chemical binding]; other site 313603006997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 313603006998 Predicted membrane protein [Function unknown]; Region: COG1288 313603006999 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 313603007000 MutS domain III; Region: MutS_III; pfam05192 313603007001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 313603007002 Walker A/P-loop; other site 313603007003 ATP binding site [chemical binding]; other site 313603007004 Q-loop/lid; other site 313603007005 ABC transporter signature motif; other site 313603007006 Walker B; other site 313603007007 D-loop; other site 313603007008 H-loop/switch region; other site 313603007009 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 313603007010 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603007011 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603007012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603007013 binding surface 313603007014 TPR motif; other site 313603007015 TPR repeat; Region: TPR_11; pfam13414 313603007016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603007017 binding surface 313603007018 TPR motif; other site 313603007019 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 313603007020 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 313603007021 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 313603007022 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603007023 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 313603007024 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 313603007025 Domain of unknown function (DUF1704); Region: DUF1704; pfam08014 313603007026 glutathione synthetase; Provisional; Region: PRK12458 313603007027 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 313603007028 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 313603007029 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 313603007030 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 313603007031 Tetramer interface [polypeptide binding]; other site 313603007032 active site 313603007033 FMN-binding site [chemical binding]; other site 313603007034 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 313603007035 FAD binding domain; Region: FAD_binding_4; pfam01565 313603007036 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 313603007037 Uncharacterized conserved protein [Function unknown]; Region: COG5276 313603007038 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 313603007039 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 313603007040 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 313603007041 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 313603007042 putative acyl-acceptor binding pocket; other site 313603007043 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 313603007044 putative catalytic site [active] 313603007045 putative metal binding site [ion binding]; other site 313603007046 putative phosphate binding site [ion binding]; other site 313603007047 Protein of unknown function, DUF479; Region: DUF479; cl01203 313603007048 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 313603007049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 313603007050 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 313603007051 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603007052 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603007053 Amino acid permease; Region: AA_permease; pfam00324 313603007054 YhhN-like protein; Region: YhhN; pfam07947 313603007055 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 313603007056 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603007057 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603007058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603007059 TPR repeat; Region: TPR_11; pfam13414 313603007060 binding surface 313603007061 TPR motif; other site 313603007062 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 313603007063 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 313603007064 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 313603007065 substrate binding pocket [chemical binding]; other site 313603007066 Ion channel; Region: Ion_trans_2; pfam07885 313603007067 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 313603007068 membrane-bound complex binding site; other site 313603007069 hinge residues; other site 313603007070 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 313603007071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603007072 Coenzyme A binding pocket [chemical binding]; other site 313603007073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 313603007074 non-specific DNA binding site [nucleotide binding]; other site 313603007075 Predicted transcriptional regulator [Transcription]; Region: COG2932 313603007076 salt bridge; other site 313603007077 sequence-specific DNA binding site [nucleotide binding]; other site 313603007078 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 313603007079 Catalytic site [active] 313603007080 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 313603007081 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 313603007082 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 313603007083 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 313603007084 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 313603007085 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 313603007086 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 313603007087 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 313603007088 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 313603007089 tetramer interface [polypeptide binding]; other site 313603007090 TPP-binding site [chemical binding]; other site 313603007091 heterodimer interface [polypeptide binding]; other site 313603007092 phosphorylation loop region [posttranslational modification] 313603007093 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 313603007094 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 313603007095 PYR/PP interface [polypeptide binding]; other site 313603007096 dimer interface [polypeptide binding]; other site 313603007097 TPP binding site [chemical binding]; other site 313603007098 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 313603007099 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 313603007100 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 313603007101 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 313603007102 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 313603007103 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 313603007104 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 313603007105 Predicted membrane protein [Function unknown]; Region: COG2259 313603007106 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 313603007107 DNA polymerase III, delta subunit; Region: holA; TIGR01128 313603007108 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 313603007109 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 313603007110 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 313603007111 Probable Catalytic site; other site 313603007112 metal-binding site 313603007113 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 313603007114 ligand binding site [chemical binding]; other site 313603007115 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 313603007116 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 313603007117 Part of AAA domain; Region: AAA_19; pfam13245 313603007118 Family description; Region: UvrD_C_2; pfam13538 313603007119 DsrE/DsrF-like family; Region: DrsE; pfam02635 313603007120 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 313603007121 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 313603007122 metal binding site [ion binding]; metal-binding site 313603007123 putative dimer interface [polypeptide binding]; other site 313603007124 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 313603007125 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 313603007126 active site 313603007127 FMN binding site [chemical binding]; other site 313603007128 substrate binding site [chemical binding]; other site 313603007129 3Fe-4S cluster binding site [ion binding]; other site 313603007130 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 313603007131 Patatin-like phospholipase; Region: Patatin; pfam01734 313603007132 active site 313603007133 nucleophile elbow; other site 313603007134 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 313603007135 Peptidase family M1; Region: Peptidase_M1; pfam01433 313603007136 Zn binding site [ion binding]; other site 313603007137 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 313603007138 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 313603007139 generic binding surface II; other site 313603007140 ssDNA binding site; other site 313603007141 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 313603007142 ATP binding site [chemical binding]; other site 313603007143 putative Mg++ binding site [ion binding]; other site 313603007144 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 313603007145 nucleotide binding region [chemical binding]; other site 313603007146 ATP-binding site [chemical binding]; other site 313603007147 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 313603007148 Tetratricopeptide repeat; Region: TPR_16; pfam13432 313603007149 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 313603007150 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 313603007151 substrate binding site [chemical binding]; other site 313603007152 ligand binding site [chemical binding]; other site 313603007153 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 313603007154 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 313603007155 substrate binding site [chemical binding]; other site 313603007156 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 313603007157 2-isopropylmalate synthase; Validated; Region: PRK00915 313603007158 active site 313603007159 catalytic residues [active] 313603007160 metal binding site [ion binding]; metal-binding site 313603007161 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 313603007162 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 313603007163 tartrate dehydrogenase; Region: TTC; TIGR02089 313603007164 CotH protein; Region: CotH; pfam08757 313603007165 Protein of unknown function (DUF2806); Region: DUF2806; pfam10987 313603007166 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 313603007167 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 313603007168 tetrameric interface [polypeptide binding]; other site 313603007169 activator binding site; other site 313603007170 NADP binding site [chemical binding]; other site 313603007171 substrate binding site [chemical binding]; other site 313603007172 catalytic residues [active] 313603007173 threonine dehydratase; Validated; Region: PRK08639 313603007174 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 313603007175 tetramer interface [polypeptide binding]; other site 313603007176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603007177 catalytic residue [active] 313603007178 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 313603007179 putative Ile/Val binding site [chemical binding]; other site 313603007180 ketol-acid reductoisomerase; Validated; Region: PRK05225 313603007181 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 313603007182 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 313603007183 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 313603007184 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 313603007185 acetolactate synthase, small subunit; Region: acolac_sm; TIGR00119 313603007186 putative valine binding site [chemical binding]; other site 313603007187 dimer interface [polypeptide binding]; other site 313603007188 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 313603007189 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 313603007190 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 313603007191 PYR/PP interface [polypeptide binding]; other site 313603007192 dimer interface [polypeptide binding]; other site 313603007193 TPP binding site [chemical binding]; other site 313603007194 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 313603007195 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 313603007196 TPP-binding site [chemical binding]; other site 313603007197 dimer interface [polypeptide binding]; other site 313603007198 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 313603007199 LytTr DNA-binding domain; Region: LytTR; smart00850 313603007200 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 313603007201 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 313603007202 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 313603007203 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 313603007204 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603007205 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 313603007206 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603007207 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 313603007208 starch binding outer membrane protein SusD; Region: SusD; cl17845 313603007209 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 313603007210 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 313603007211 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 313603007212 NAD(P) binding site [chemical binding]; other site 313603007213 catalytic residues [active] 313603007214 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 313603007215 FMN binding site [chemical binding]; other site 313603007216 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 313603007217 dimer interface [polypeptide binding]; other site 313603007218 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 313603007219 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 313603007220 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 313603007221 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 313603007222 putative active site [active] 313603007223 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 313603007224 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 313603007225 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 313603007226 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 313603007227 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 313603007228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603007229 homodimer interface [polypeptide binding]; other site 313603007230 catalytic residue [active] 313603007231 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 313603007232 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603007233 TPR motif; other site 313603007234 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 313603007235 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 313603007236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 313603007237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603007238 Walker A motif; other site 313603007239 ATP binding site [chemical binding]; other site 313603007240 Walker B motif; other site 313603007241 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 313603007242 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 313603007243 Secretin and TonB N terminus short domain; Region: STN; smart00965 313603007244 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603007245 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603007246 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 313603007247 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 313603007248 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603007249 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603007250 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 313603007251 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 313603007252 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 313603007253 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 313603007254 active site 313603007255 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 313603007256 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 313603007257 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 313603007258 Ligand Binding Site [chemical binding]; other site 313603007259 TilS substrate C-terminal domain; Region: TilS_C; smart00977 313603007260 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 313603007261 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 313603007262 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 313603007263 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 313603007264 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 313603007265 Predicted flavoprotein [General function prediction only]; Region: COG0431 313603007266 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 313603007267 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 313603007268 Acyltransferase family; Region: Acyl_transf_3; pfam01757 313603007269 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 313603007270 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 313603007271 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 313603007272 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 313603007273 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 313603007274 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 313603007275 putative DNA binding site [nucleotide binding]; other site 313603007276 putative Zn2+ binding site [ion binding]; other site 313603007277 AsnC family; Region: AsnC_trans_reg; pfam01037 313603007278 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 313603007279 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 313603007280 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603007281 catalytic residue [active] 313603007282 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 313603007283 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 313603007284 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 313603007285 dimer interface [polypeptide binding]; other site 313603007286 decamer (pentamer of dimers) interface [polypeptide binding]; other site 313603007287 catalytic triad [active] 313603007288 peroxidatic and resolving cysteines [active] 313603007289 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 313603007290 catalytic residues [active] 313603007291 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 313603007292 dimer interface [polypeptide binding]; other site 313603007293 catalytic triad [active] 313603007294 peroxidatic and resolving cysteines [active] 313603007295 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 313603007296 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 313603007297 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 313603007298 Predicted permeases [General function prediction only]; Region: COG0795 313603007299 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 313603007300 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 313603007301 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 313603007302 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 313603007303 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 313603007304 dimerization interface [polypeptide binding]; other site 313603007305 active site 313603007306 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 313603007307 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 313603007308 inhibitor-cofactor binding pocket; inhibition site 313603007309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603007310 catalytic residue [active] 313603007311 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 313603007312 dimer interface [polypeptide binding]; other site 313603007313 FMN binding site [chemical binding]; other site 313603007314 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 313603007315 FOG: PKD repeat [General function prediction only]; Region: COG3291 313603007316 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 313603007317 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 313603007318 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 313603007319 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 313603007320 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 313603007321 Cytochrome c; Region: Cytochrom_C; pfam00034 313603007322 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 313603007323 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 313603007324 active site 313603007325 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 313603007326 dihydroorotase; Validated; Region: pyrC; PRK09357 313603007327 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 313603007328 active site 313603007329 putative hydrolase; Provisional; Region: PRK11460 313603007330 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 313603007331 putative hydrolase; Provisional; Region: PRK02113 313603007332 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 313603007333 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 313603007334 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 313603007335 catalytic triad [active] 313603007336 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 313603007337 endonuclease III; Region: ENDO3c; smart00478 313603007338 minor groove reading motif; other site 313603007339 helix-hairpin-helix signature motif; other site 313603007340 substrate binding pocket [chemical binding]; other site 313603007341 active site 313603007342 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 313603007343 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603007344 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603007345 DNA binding residues [nucleotide binding] 313603007346 RNA polymerase sigma factor; Provisional; Region: PRK12513 313603007347 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603007348 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603007349 DNA binding residues [nucleotide binding] 313603007350 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 313603007351 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 313603007352 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 313603007353 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 313603007354 origin recognition complex 1 protein; Provisional; Region: PTZ00112 313603007355 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 313603007356 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 313603007357 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 313603007358 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 313603007359 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 313603007360 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 313603007361 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 313603007362 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 313603007363 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603007364 catalytic residue [active] 313603007365 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 313603007366 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 313603007367 dimer interface [polypeptide binding]; other site 313603007368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603007369 catalytic residue [active] 313603007370 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 313603007371 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 313603007372 hypothetical protein; Provisional; Region: PRK14623 313603007373 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 313603007374 catalytic residues [active] 313603007375 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 313603007376 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 313603007377 ligand binding site [chemical binding]; other site 313603007378 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 313603007379 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 313603007380 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603007381 catalytic residue [active] 313603007382 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 313603007383 active site 313603007384 PCRF domain; Region: PCRF; pfam03462 313603007385 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 313603007386 RF-1 domain; Region: RF-1; pfam00472 313603007387 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 313603007388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 313603007389 motif II; other site 313603007390 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 313603007391 ArsC family; Region: ArsC; pfam03960 313603007392 catalytic residues [active] 313603007393 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603007394 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 313603007395 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603007396 fumarate hydratase; Reviewed; Region: fumC; PRK00485 313603007397 Class II fumarases; Region: Fumarase_classII; cd01362 313603007398 active site 313603007399 tetramer interface [polypeptide binding]; other site 313603007400 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 313603007401 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 313603007402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603007403 Coenzyme A binding pocket [chemical binding]; other site 313603007404 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 313603007405 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 313603007406 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 313603007407 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 313603007408 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 313603007409 ABC transporter; Region: ABC_tran_2; pfam12848 313603007410 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 313603007411 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603007412 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603007413 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 313603007414 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 313603007415 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603007416 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603007417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603007418 TPR motif; other site 313603007419 MG2 domain; Region: A2M_N; pfam01835 313603007420 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 313603007421 active site 313603007422 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 313603007423 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 313603007424 acyl-activating enzyme (AAE) consensus motif; other site 313603007425 AMP binding site [chemical binding]; other site 313603007426 active site 313603007427 CoA binding site [chemical binding]; other site 313603007428 CAAX protease self-immunity; Region: Abi; pfam02517 313603007429 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 313603007430 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 313603007431 active site 313603007432 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 313603007433 short chain dehydrogenase; Provisional; Region: PRK06181 313603007434 NADP binding site [chemical binding]; other site 313603007435 homodimer interface [polypeptide binding]; other site 313603007436 substrate binding site [chemical binding]; other site 313603007437 active site 313603007438 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 313603007439 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 313603007440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 313603007441 binding surface 313603007442 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603007443 TPR motif; other site 313603007444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 313603007445 Histidine kinase; Region: HisKA_2; pfam07568 313603007446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603007447 ATP binding site [chemical binding]; other site 313603007448 Mg2+ binding site [ion binding]; other site 313603007449 G-X-G motif; other site 313603007450 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 313603007451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603007452 active site 313603007453 phosphorylation site [posttranslational modification] 313603007454 intermolecular recognition site; other site 313603007455 dimerization interface [polypeptide binding]; other site 313603007456 LytTr DNA-binding domain; Region: LytTR; smart00850 313603007457 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 313603007458 UbiA prenyltransferase family; Region: UbiA; pfam01040 313603007459 Sporulation related domain; Region: SPOR; cl10051 313603007460 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 313603007461 S1 domain; Region: S1_2; pfam13509 313603007462 S1 domain; Region: S1_2; pfam13509 313603007463 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 313603007464 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 313603007465 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 313603007466 dimer interface [polypeptide binding]; other site 313603007467 tetramer interface [polypeptide binding]; other site 313603007468 PYR/PP interface [polypeptide binding]; other site 313603007469 TPP binding site [chemical binding]; other site 313603007470 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 313603007471 TPP-binding site; other site 313603007472 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 313603007473 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 313603007474 CoenzymeA binding site [chemical binding]; other site 313603007475 subunit interaction site [polypeptide binding]; other site 313603007476 PHB binding site; other site 313603007477 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 313603007478 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 313603007479 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 313603007480 Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396 313603007481 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 313603007482 active site 313603007483 metal binding site [ion binding]; metal-binding site 313603007484 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 313603007485 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 313603007486 nucleotide binding site [chemical binding]; other site 313603007487 NEF interaction site [polypeptide binding]; other site 313603007488 SBD interface [polypeptide binding]; other site 313603007489 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 313603007490 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 313603007491 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 313603007492 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603007493 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603007494 active site 313603007495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603007496 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 313603007497 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603007498 OsmC-like protein; Region: OsmC; pfam02566 313603007499 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 313603007500 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 313603007501 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 313603007502 PA/protease or protease-like domain interface [polypeptide binding]; other site 313603007503 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 313603007504 Peptidase family M28; Region: Peptidase_M28; pfam04389 313603007505 metal binding site [ion binding]; metal-binding site 313603007506 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 313603007507 TPR repeat; Region: TPR_11; pfam13414 313603007508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603007509 TPR motif; other site 313603007510 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 313603007511 active site 313603007512 catalytic triad [active] 313603007513 oxyanion hole [active] 313603007514 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 313603007515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603007516 Coenzyme A binding pocket [chemical binding]; other site 313603007517 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 313603007518 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 313603007519 putative FMN binding site [chemical binding]; other site 313603007520 putative dimer interface [polypeptide binding]; other site 313603007521 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 313603007522 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 313603007523 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 313603007524 active site 313603007525 metal binding site [ion binding]; metal-binding site 313603007526 Protein of unknown function (DUF975); Region: DUF975; cl10504 313603007527 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 313603007528 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 313603007529 DNA binding residues [nucleotide binding] 313603007530 dimerization interface [polypeptide binding]; other site 313603007531 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 313603007532 active site 313603007533 metal binding site [ion binding]; metal-binding site 313603007534 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 313603007535 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 313603007536 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 313603007537 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 313603007538 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 313603007539 ligand binding site [chemical binding]; other site 313603007540 Predicted flavoprotein [General function prediction only]; Region: COG0431 313603007541 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 313603007542 Pirin; Region: Pirin; pfam02678 313603007543 Pirin-related protein [General function prediction only]; Region: COG1741 313603007544 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 313603007545 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 313603007546 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 313603007547 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 313603007548 oligomerization interface [polypeptide binding]; other site 313603007549 active site 313603007550 metal binding site [ion binding]; metal-binding site 313603007551 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 313603007552 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 313603007553 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 313603007554 active site 313603007555 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 313603007556 AAA domain; Region: AAA_17; cl17253 313603007557 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 313603007558 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 313603007559 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 313603007560 active site 313603007561 catalytic residues [active] 313603007562 metal binding site [ion binding]; metal-binding site 313603007563 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 313603007564 tartrate dehydrogenase; Region: TTC; TIGR02089 313603007565 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 313603007566 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 313603007567 catalytic residues [active] 313603007568 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 313603007569 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 313603007570 putative tRNA-binding site [nucleotide binding]; other site 313603007571 B3/4 domain; Region: B3_4; pfam03483 313603007572 tRNA synthetase B5 domain; Region: B5; pfam03484 313603007573 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 313603007574 dimer interface [polypeptide binding]; other site 313603007575 motif 1; other site 313603007576 motif 3; other site 313603007577 motif 2; other site 313603007578 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 313603007579 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 313603007580 Fasciclin domain; Region: Fasciclin; pfam02469 313603007581 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 313603007582 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 313603007583 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 313603007584 ABC transporter; Region: ABC_tran_2; pfam12848 313603007585 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 313603007586 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 313603007587 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 313603007588 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 313603007589 active site 313603007590 intersubunit interactions; other site 313603007591 catalytic residue [active] 313603007592 short chain dehydrogenase; Validated; Region: PRK06182 313603007593 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 313603007594 NADP binding site [chemical binding]; other site 313603007595 active site 313603007596 steroid binding site; other site 313603007597 Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096 313603007598 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 313603007599 active site 313603007600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 313603007601 PAS domain; Region: PAS_9; pfam13426 313603007602 putative active site [active] 313603007603 heme pocket [chemical binding]; other site 313603007604 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 313603007605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 313603007606 phosphorylation site [posttranslational modification] 313603007607 intermolecular recognition site; other site 313603007608 LytTr DNA-binding domain; Region: LytTR; smart00850 313603007609 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 313603007610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603007611 active site 313603007612 phosphorylation site [posttranslational modification] 313603007613 intermolecular recognition site; other site 313603007614 dimerization interface [polypeptide binding]; other site 313603007615 LytTr DNA-binding domain; Region: LytTR; smart00850 313603007616 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603007617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603007618 binding surface 313603007619 TPR motif; other site 313603007620 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603007621 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603007622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603007623 binding surface 313603007624 TPR motif; other site 313603007625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 313603007626 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 313603007627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603007628 active site 313603007629 phosphorylation site [posttranslational modification] 313603007630 intermolecular recognition site; other site 313603007631 dimerization interface [polypeptide binding]; other site 313603007632 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 313603007633 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 313603007634 dimer interface [polypeptide binding]; other site 313603007635 active site 313603007636 glycine-pyridoxal phosphate binding site [chemical binding]; other site 313603007637 folate binding site [chemical binding]; other site 313603007638 fumarylacetoacetase; Region: PLN02856 313603007639 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 313603007640 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 313603007641 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 313603007642 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 313603007643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603007644 Walker A motif; other site 313603007645 ATP binding site [chemical binding]; other site 313603007646 Walker B motif; other site 313603007647 arginine finger; other site 313603007648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603007649 Walker A motif; other site 313603007650 ATP binding site [chemical binding]; other site 313603007651 Walker B motif; other site 313603007652 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 313603007653 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 313603007654 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 313603007655 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 313603007656 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 313603007657 catalytic core [active] 313603007658 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 313603007659 SmpB-tmRNA interface; other site 313603007660 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 313603007661 Methyltransferase domain; Region: Methyltransf_18; pfam12847 313603007662 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603007663 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603007664 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 313603007665 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 313603007666 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 313603007667 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 313603007668 Uncharacterized conserved protein [Function unknown]; Region: COG4198 313603007669 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 313603007670 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 313603007671 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 313603007672 catalytic residue [active] 313603007673 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 313603007674 active site 313603007675 catalytic site [active] 313603007676 substrate binding site [chemical binding]; other site 313603007677 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 313603007678 GIY-YIG motif/motif A; other site 313603007679 active site 313603007680 catalytic site [active] 313603007681 putative DNA binding site [nucleotide binding]; other site 313603007682 metal binding site [ion binding]; metal-binding site 313603007683 Ion transport protein; Region: Ion_trans; pfam00520 313603007684 Ion channel; Region: Ion_trans_2; pfam07885 313603007685 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 313603007686 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 313603007687 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 313603007688 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 313603007689 ATP-binding site [chemical binding]; other site 313603007690 Gluconate-6-phosphate binding site [chemical binding]; other site 313603007691 Shikimate kinase; Region: SKI; pfam01202 313603007692 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 313603007693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603007694 active site 313603007695 phosphorylation site [posttranslational modification] 313603007696 intermolecular recognition site; other site 313603007697 dimerization interface [polypeptide binding]; other site 313603007698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 313603007699 DNA binding site [nucleotide binding] 313603007700 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 313603007701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 313603007702 dimer interface [polypeptide binding]; other site 313603007703 phosphorylation site [posttranslational modification] 313603007704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603007705 ATP binding site [chemical binding]; other site 313603007706 Mg2+ binding site [ion binding]; other site 313603007707 G-X-G motif; other site 313603007708 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 313603007709 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 313603007710 CoA-binding site [chemical binding]; other site 313603007711 ATP-binding [chemical binding]; other site 313603007712 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 313603007713 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 313603007714 active site 313603007715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603007716 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 313603007717 NAD(P) binding site [chemical binding]; other site 313603007718 active site 313603007719 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 313603007720 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 313603007721 Walker A/P-loop; other site 313603007722 ATP binding site [chemical binding]; other site 313603007723 Q-loop/lid; other site 313603007724 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 313603007725 ABC transporter signature motif; other site 313603007726 Walker B; other site 313603007727 D-loop; other site 313603007728 H-loop/switch region; other site 313603007729 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 313603007730 Flavoprotein; Region: Flavoprotein; pfam02441 313603007731 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 313603007732 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 313603007733 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 313603007734 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 313603007735 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 313603007736 dimer interface [polypeptide binding]; other site 313603007737 active site 313603007738 catalytic residue [active] 313603007739 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 313603007740 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 313603007741 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 313603007742 active site 313603007743 metal binding site [ion binding]; metal-binding site 313603007744 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 313603007745 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 313603007746 Peptidase family M23; Region: Peptidase_M23; pfam01551 313603007747 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 313603007748 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 313603007749 nucleotide binding pocket [chemical binding]; other site 313603007750 K-X-D-G motif; other site 313603007751 catalytic site [active] 313603007752 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 313603007753 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 313603007754 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 313603007755 Dimer interface [polypeptide binding]; other site 313603007756 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 313603007757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603007758 S-adenosylmethionine binding site [chemical binding]; other site 313603007759 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 313603007760 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 313603007761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603007762 Coenzyme A binding pocket [chemical binding]; other site 313603007763 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 313603007764 catalytic motif [active] 313603007765 Zn binding site [ion binding]; other site 313603007766 RibD C-terminal domain; Region: RibD_C; cl17279 313603007767 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 313603007768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 313603007769 motif II; other site 313603007770 Uncharacterized conserved protein [Function unknown]; Region: COG1739 313603007771 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 313603007772 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 313603007773 active site 313603007774 DnaA N-terminal domain; Region: DnaA_N; pfam11638 313603007775 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 313603007776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603007777 Walker A motif; other site 313603007778 ATP binding site [chemical binding]; other site 313603007779 Walker B motif; other site 313603007780 arginine finger; other site 313603007781 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 313603007782 DnaA box-binding interface [nucleotide binding]; other site 313603007783 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 313603007784 Low molecular weight phosphatase family; Region: LMWPc; cd00115 313603007785 active site 313603007786 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 313603007787 putative SAM binding site [chemical binding]; other site 313603007788 homodimer interface [polypeptide binding]; other site 313603007789 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 313603007790 YceG-like family; Region: YceG; pfam02618 313603007791 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 313603007792 dimerization interface [polypeptide binding]; other site 313603007793 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 313603007794 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 313603007795 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 313603007796 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 313603007797 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 313603007798 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 313603007799 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 313603007800 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 313603007801 protein binding site [polypeptide binding]; other site 313603007802 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 313603007803 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 313603007804 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 313603007805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603007806 Coenzyme A binding pocket [chemical binding]; other site 313603007807 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 313603007808 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 313603007809 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 313603007810 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 313603007811 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603007812 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603007813 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 313603007814 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 313603007815 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 313603007816 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 313603007817 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 313603007818 oligomer interface [polypeptide binding]; other site 313603007819 active site 313603007820 metal binding site [ion binding]; metal-binding site 313603007821 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 313603007822 nudix motif; other site 313603007823 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 313603007824 motif 1; other site 313603007825 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 313603007826 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 313603007827 active site 313603007828 dimer interface [polypeptide binding]; other site 313603007829 motif 2; other site 313603007830 motif 3; other site 313603007831 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 313603007832 anticodon binding site; other site 313603007833 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 313603007834 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 313603007835 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 313603007836 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 313603007837 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 313603007838 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 313603007839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603007840 active site 313603007841 phosphorylation site [posttranslational modification] 313603007842 intermolecular recognition site; other site 313603007843 dimerization interface [polypeptide binding]; other site 313603007844 LytTr DNA-binding domain; Region: LytTR; smart00850 313603007845 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 313603007846 primosomal protein N' Region: priA; TIGR00595 313603007847 ATP binding site [chemical binding]; other site 313603007848 putative Mg++ binding site [ion binding]; other site 313603007849 helicase superfamily c-terminal domain; Region: HELICc; smart00490 313603007850 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 313603007851 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 313603007852 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 313603007853 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 313603007854 dimerization interface [polypeptide binding]; other site 313603007855 active site 313603007856 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 313603007857 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 313603007858 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 313603007859 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 313603007860 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 313603007861 ligand binding site [chemical binding]; other site 313603007862 NAD binding site [chemical binding]; other site 313603007863 tetramer interface [polypeptide binding]; other site 313603007864 catalytic site [active] 313603007865 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 313603007866 L-serine binding site [chemical binding]; other site 313603007867 ACT domain interface; other site 313603007868 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 313603007869 nudix motif; other site 313603007870 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 313603007871 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 313603007872 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 313603007873 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 313603007874 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 313603007875 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 313603007876 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 313603007877 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 313603007878 active site 313603007879 dimerization interface [polypeptide binding]; other site 313603007880 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 313603007881 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 313603007882 DEAD-like helicases superfamily; Region: DEXDc; smart00487 313603007883 ATP binding site [chemical binding]; other site 313603007884 Mg++ binding site [ion binding]; other site 313603007885 motif III; other site 313603007886 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 313603007887 nucleotide binding region [chemical binding]; other site 313603007888 ATP-binding site [chemical binding]; other site 313603007889 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 313603007890 RNA binding site [nucleotide binding]; other site 313603007891 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603007892 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 313603007893 active site 313603007894 catalytic site [active] 313603007895 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 313603007896 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 313603007897 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 313603007898 putative hydrophobic ligand binding site [chemical binding]; other site 313603007899 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 313603007900 NAD-dependent deacetylase; Provisional; Region: PRK00481 313603007901 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 313603007902 NAD+ binding site [chemical binding]; other site 313603007903 substrate binding site [chemical binding]; other site 313603007904 Zn binding site [ion binding]; other site 313603007905 Haem-binding domain; Region: Haem_bd; pfam14376 313603007906 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 313603007907 Mechanosensitive ion channel; Region: MS_channel; pfam00924 313603007908 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 313603007909 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 313603007910 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 313603007911 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 313603007912 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603007913 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603007914 DNA binding residues [nucleotide binding] 313603007915 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 313603007916 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 313603007917 Catalytic dyad [active] 313603007918 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 313603007919 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603007920 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 313603007921 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 313603007922 putative ligand binding site [chemical binding]; other site 313603007923 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 313603007924 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 313603007925 ABC-ATPase subunit interface; other site 313603007926 dimer interface [polypeptide binding]; other site 313603007927 putative PBP binding regions; other site 313603007928 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 313603007929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 313603007930 ABC transporter signature motif; other site 313603007931 Walker B; other site 313603007932 D-loop; other site 313603007933 H-loop/switch region; other site 313603007934 DNA recombination protein RmuC; Provisional; Region: PRK10361 313603007935 RmuC family; Region: RmuC; pfam02646 313603007936 Nucleopolyhedrovirus protein of unknown function (DUF912); Region: DUF912; pfam06024 313603007937 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 313603007938 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 313603007939 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 313603007940 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 313603007941 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 313603007942 ATP-grasp domain; Region: ATP-grasp_4; cl17255 313603007943 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 313603007944 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 313603007945 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 313603007946 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 313603007947 ATP-grasp domain; Region: ATP-grasp_4; cl17255 313603007948 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 313603007949 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 313603007950 N-acetyl-D-glucosamine binding site [chemical binding]; other site 313603007951 catalytic residue [active] 313603007952 Predicted acetyltransferase [General function prediction only]; Region: COG2388 313603007953 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 313603007954 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 313603007955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 313603007956 FeS/SAM binding site; other site 313603007957 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 313603007958 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 313603007959 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 313603007960 putative trimer interface [polypeptide binding]; other site 313603007961 putative CoA binding site [chemical binding]; other site 313603007962 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 313603007963 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 313603007964 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 313603007965 Ligand binding site; other site 313603007966 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 313603007967 Putative Catalytic site; other site 313603007968 DXD motif; other site 313603007969 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 313603007970 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 313603007971 active site 313603007972 substrate binding site [chemical binding]; other site 313603007973 metal binding site [ion binding]; metal-binding site 313603007974 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 313603007975 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 313603007976 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 313603007977 Walker A/P-loop; other site 313603007978 ATP binding site [chemical binding]; other site 313603007979 Q-loop/lid; other site 313603007980 ABC transporter signature motif; other site 313603007981 Walker B; other site 313603007982 D-loop; other site 313603007983 H-loop/switch region; other site 313603007984 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 313603007985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603007986 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603007987 DNA binding residues [nucleotide binding] 313603007988 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 313603007989 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 313603007990 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 313603007991 putative active site [active] 313603007992 putative FMN binding site [chemical binding]; other site 313603007993 putative substrate binding site [chemical binding]; other site 313603007994 putative catalytic residue [active] 313603007995 16S rRNA methyltransferase B; Provisional; Region: PRK14902 313603007996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603007997 S-adenosylmethionine binding site [chemical binding]; other site 313603007998 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 313603007999 amidohydrolase; Region: amidohydrolases; TIGR01891 313603008000 putative metal binding site [ion binding]; other site 313603008001 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 313603008002 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 313603008003 dimerization interface [polypeptide binding]; other site 313603008004 ATP binding site [chemical binding]; other site 313603008005 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 313603008006 dimerization interface [polypeptide binding]; other site 313603008007 ATP binding site [chemical binding]; other site 313603008008 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 313603008009 putative active site [active] 313603008010 catalytic triad [active] 313603008011 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 313603008012 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 313603008013 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 313603008014 active site 313603008015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 313603008016 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 313603008017 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 313603008018 acyl-activating enzyme (AAE) consensus motif; other site 313603008019 putative AMP binding site [chemical binding]; other site 313603008020 putative active site [active] 313603008021 putative CoA binding site [chemical binding]; other site 313603008022 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 313603008023 MarR family; Region: MarR_2; pfam12802 313603008024 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 313603008025 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 313603008026 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 313603008027 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 313603008028 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 313603008029 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 313603008030 substrate binding site [chemical binding]; other site 313603008031 oxyanion hole (OAH) forming residues; other site 313603008032 trimer interface [polypeptide binding]; other site 313603008033 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 313603008034 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 313603008035 dimer interface [polypeptide binding]; other site 313603008036 active site 313603008037 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 313603008038 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 313603008039 active site 313603008040 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 313603008041 active site 313603008042 catalytic residues [active] 313603008043 Peptidase family M49; Region: Peptidase_M49; pfam03571 313603008044 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 313603008045 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603008046 catalytic residue [active] 313603008047 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 313603008048 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 313603008049 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 313603008050 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 313603008051 active site 313603008052 homotetramer interface [polypeptide binding]; other site 313603008053 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 313603008054 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 313603008055 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 313603008056 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 313603008057 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 313603008058 putative metal binding site [ion binding]; other site 313603008059 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 313603008060 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 313603008061 Zn binding site [ion binding]; other site 313603008062 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 313603008063 active site 313603008064 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 313603008065 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 313603008066 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 313603008067 tyrosine decarboxylase; Region: PLN02880 313603008068 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 313603008069 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603008070 catalytic residue [active] 313603008071 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 313603008072 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 313603008073 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 313603008074 Trehalose utilisation; Region: ThuA; pfam06283 313603008075 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 313603008076 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 313603008077 Cytochrome c; Region: Cytochrom_C; cl11414 313603008078 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 313603008079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 313603008080 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 313603008081 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 313603008082 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 313603008083 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 313603008084 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 313603008085 protein binding site [polypeptide binding]; other site 313603008086 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 313603008087 Domain interface; other site 313603008088 Peptide binding site; other site 313603008089 Active site tetrad [active] 313603008090 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 313603008091 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 313603008092 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 313603008093 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 313603008094 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603008095 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 313603008096 active site 313603008097 Ycf48-like protein; Provisional; Region: PRK13684 313603008098 VPS10 domain; Region: VPS10; smart00602 313603008099 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 313603008100 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 313603008101 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 313603008102 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 313603008103 YceI-like domain; Region: YceI; pfam04264 313603008104 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 313603008105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603008106 active site 313603008107 phosphorylation site [posttranslational modification] 313603008108 intermolecular recognition site; other site 313603008109 dimerization interface [polypeptide binding]; other site 313603008110 LytTr DNA-binding domain; Region: LytTR; smart00850 313603008111 2TM domain; Region: 2TM; pfam13239 313603008112 2TM domain; Region: 2TM; pfam13239 313603008113 2TM domain; Region: 2TM; pfam13239 313603008114 Histidine kinase; Region: His_kinase; pfam06580 313603008115 2TM domain; Region: 2TM; pfam13239 313603008116 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 313603008117 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 313603008118 helicase 45; Provisional; Region: PTZ00424 313603008119 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 313603008120 ATP binding site [chemical binding]; other site 313603008121 Mg++ binding site [ion binding]; other site 313603008122 motif III; other site 313603008123 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 313603008124 nucleotide binding region [chemical binding]; other site 313603008125 ATP-binding site [chemical binding]; other site 313603008126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 313603008127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 313603008128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603008129 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 313603008130 active site 313603008131 phosphorylation site [posttranslational modification] 313603008132 intermolecular recognition site; other site 313603008133 dimerization interface [polypeptide binding]; other site 313603008134 LytTr DNA-binding domain; Region: LytTR; smart00850 313603008135 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603008136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603008137 binding surface 313603008138 TPR motif; other site 313603008139 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603008140 Tetratricopeptide repeat; Region: TPR_12; pfam13424 313603008141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603008142 TPR motif; other site 313603008143 binding surface 313603008144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 313603008145 Histidine kinase; Region: HisKA_2; pfam07568 313603008146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603008147 ATP binding site [chemical binding]; other site 313603008148 Mg2+ binding site [ion binding]; other site 313603008149 G-X-G motif; other site 313603008150 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 313603008151 SnoaL-like domain; Region: SnoaL_2; pfam12680 313603008152 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 313603008153 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 313603008154 dimer interface [polypeptide binding]; other site 313603008155 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 313603008156 ligand binding site [chemical binding]; other site 313603008157 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 313603008158 putative catalytic site [active] 313603008159 putative metal binding site [ion binding]; other site 313603008160 putative phosphate binding site [ion binding]; other site 313603008161 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 313603008162 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 313603008163 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 313603008164 putative NAD(P) binding site [chemical binding]; other site 313603008165 active site 313603008166 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 313603008167 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 313603008168 cyclase homology domain; Region: CHD; cd07302 313603008169 nucleotidyl binding site; other site 313603008170 metal binding site [ion binding]; metal-binding site 313603008171 dimer interface [polypeptide binding]; other site 313603008172 Helix-turn-helix domain; Region: HTH_18; pfam12833 313603008173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603008174 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 313603008175 Acyltransferase family; Region: Acyl_transf_3; pfam01757 313603008176 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 313603008177 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 313603008178 Serine hydrolase; Region: Ser_hydrolase; cl17834 313603008179 nucleophilic elbow; other site 313603008180 catalytic triad; other site 313603008181 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 313603008182 Peptidase family M23; Region: Peptidase_M23; pfam01551 313603008183 DinB superfamily; Region: DinB_2; pfam12867 313603008184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603008185 Major Facilitator Superfamily; Region: MFS_1; pfam07690 313603008186 putative substrate translocation pore; other site 313603008187 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 313603008188 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 313603008189 PQQ-like domain; Region: PQQ_2; pfam13360 313603008190 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 313603008191 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 313603008192 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603008193 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 313603008194 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603008195 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 313603008196 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 313603008197 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 313603008198 dimerization interface [polypeptide binding]; other site 313603008199 DPS ferroxidase diiron center [ion binding]; other site 313603008200 ion pore; other site 313603008201 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 313603008202 HlyD family secretion protein; Region: HlyD_3; pfam13437 313603008203 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603008204 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 313603008205 FtsX-like permease family; Region: FtsX; pfam02687 313603008206 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 313603008207 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 313603008208 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 313603008209 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 313603008210 dimerization interface [polypeptide binding]; other site 313603008211 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 313603008212 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 313603008213 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 313603008214 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 313603008215 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 313603008216 dimer interface [polypeptide binding]; other site 313603008217 ADP-ribose binding site [chemical binding]; other site 313603008218 active site 313603008219 nudix motif; other site 313603008220 metal binding site [ion binding]; metal-binding site 313603008221 Uncharacterized conserved protein [Function unknown]; Region: COG2013 313603008222 Tic20-like protein; Region: Tic20; pfam09685 313603008223 Predicted transcriptional regulators [Transcription]; Region: COG1695 313603008224 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 313603008225 PspC domain; Region: PspC; pfam04024 313603008226 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 313603008227 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 313603008228 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 313603008229 active site 313603008230 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 313603008231 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 313603008232 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603008233 catalytic residue [active] 313603008234 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 313603008235 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 313603008236 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 313603008237 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 313603008238 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 313603008239 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 313603008240 putative active site [active] 313603008241 catalytic site [active] 313603008242 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 313603008243 putative active site [active] 313603008244 catalytic site [active] 313603008245 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 313603008246 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 313603008247 putative ligand binding site [chemical binding]; other site 313603008248 putative NAD binding site [chemical binding]; other site 313603008249 catalytic site [active] 313603008250 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 313603008251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603008252 active site 313603008253 phosphorylation site [posttranslational modification] 313603008254 intermolecular recognition site; other site 313603008255 dimerization interface [polypeptide binding]; other site 313603008256 LytTr DNA-binding domain; Region: LytTR; smart00850 313603008257 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 313603008258 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 313603008259 Beta-Casp domain; Region: Beta-Casp; pfam10996 313603008260 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 313603008261 ATP cone domain; Region: ATP-cone; pfam03477 313603008262 Restriction endonuclease; Region: Mrr_cat; pfam04471 313603008263 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603008264 Ligand Binding Site [chemical binding]; other site 313603008265 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603008266 Ligand Binding Site [chemical binding]; other site 313603008267 Universal stress protein family; Region: Usp; pfam00582 313603008268 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603008269 Ligand Binding Site [chemical binding]; other site 313603008270 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 313603008271 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 313603008272 catalytic residues [active] 313603008273 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603008274 Ligand Binding Site [chemical binding]; other site 313603008275 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603008276 Ligand Binding Site [chemical binding]; other site 313603008277 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 313603008278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603008279 active site 313603008280 phosphorylation site [posttranslational modification] 313603008281 intermolecular recognition site; other site 313603008282 dimerization interface [polypeptide binding]; other site 313603008283 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 313603008284 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 313603008285 ligand binding site [chemical binding]; other site 313603008286 flexible hinge region; other site 313603008287 putative switch regulator; other site 313603008288 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 313603008289 non-specific DNA interactions [nucleotide binding]; other site 313603008290 DNA binding site [nucleotide binding] 313603008291 sequence specific DNA binding site [nucleotide binding]; other site 313603008292 putative cAMP binding site [chemical binding]; other site 313603008293 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 313603008294 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 313603008295 putative active site [active] 313603008296 heme pocket [chemical binding]; other site 313603008297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 313603008298 dimer interface [polypeptide binding]; other site 313603008299 phosphorylation site [posttranslational modification] 313603008300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603008301 ATP binding site [chemical binding]; other site 313603008302 Mg2+ binding site [ion binding]; other site 313603008303 G-X-G motif; other site 313603008304 chaperone protein DnaJ; Provisional; Region: PRK14299 313603008305 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 313603008306 HSP70 interaction site [polypeptide binding]; other site 313603008307 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 313603008308 dimer interface [polypeptide binding]; other site 313603008309 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 313603008310 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 313603008311 HlyD family secretion protein; Region: HlyD_3; pfam13437 313603008312 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 313603008313 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 313603008314 FtsX-like permease family; Region: FtsX; pfam02687 313603008315 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 313603008316 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 313603008317 Walker A/P-loop; other site 313603008318 ATP binding site [chemical binding]; other site 313603008319 Q-loop/lid; other site 313603008320 ABC transporter signature motif; other site 313603008321 Walker B; other site 313603008322 D-loop; other site 313603008323 H-loop/switch region; other site 313603008324 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 313603008325 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603008326 Ligand Binding Site [chemical binding]; other site 313603008327 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 313603008328 Ligand Binding Site [chemical binding]; other site 313603008329 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 313603008330 30S subunit binding site; other site 313603008331 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 313603008332 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 313603008333 dimer interface [polypeptide binding]; other site 313603008334 active site 313603008335 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 313603008336 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 313603008337 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 313603008338 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 313603008339 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 313603008340 active site 313603008341 catalytic residues [active] 313603008342 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603008343 Sulfatase; Region: Sulfatase; pfam00884 313603008344 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603008345 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603008346 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 313603008347 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 313603008348 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 313603008349 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 313603008350 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 313603008351 TPP-binding site [chemical binding]; other site 313603008352 dimer interface [polypeptide binding]; other site 313603008353 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 313603008354 PYR/PP interface [polypeptide binding]; other site 313603008355 dimer interface [polypeptide binding]; other site 313603008356 TPP binding site [chemical binding]; other site 313603008357 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 313603008358 Domain of unknown function (DUF718); Region: DUF718; pfam05336 313603008359 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 313603008360 active site 313603008361 catalytic triad [active] 313603008362 oxyanion hole [active] 313603008363 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 313603008364 HEAT repeats; Region: HEAT_2; pfam13646 313603008365 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 313603008366 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 313603008367 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603008368 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603008369 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 313603008370 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 313603008371 extended (e) SDRs; Region: SDR_e; cd08946 313603008372 NAD(P) binding site [chemical binding]; other site 313603008373 active site 313603008374 substrate binding site [chemical binding]; other site 313603008375 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 313603008376 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 313603008377 NAD(P) binding site [chemical binding]; other site 313603008378 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603008379 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603008380 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 313603008381 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 313603008382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 313603008383 Major Facilitator Superfamily; Region: MFS_1; pfam07690 313603008384 putative substrate translocation pore; other site 313603008385 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 313603008386 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 313603008387 Metal-binding active site; metal-binding site 313603008388 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 313603008389 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 313603008390 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 313603008391 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603008392 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 313603008393 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603008394 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603008395 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 313603008396 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 313603008397 putative catalytic site [active] 313603008398 putative metal binding site [ion binding]; other site 313603008399 putative phosphate binding site [ion binding]; other site 313603008400 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 313603008401 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 313603008402 acyl-activating enzyme (AAE) consensus motif; other site 313603008403 putative AMP binding site [chemical binding]; other site 313603008404 putative active site [active] 313603008405 putative CoA binding site [chemical binding]; other site 313603008406 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 313603008407 putative active site [active] 313603008408 putative catalytic site [active] 313603008409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603008410 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 313603008411 NAD(P) binding site [chemical binding]; other site 313603008412 active site 313603008413 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 313603008414 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 313603008415 NAD(P) binding site [chemical binding]; other site 313603008416 Prostaglandin dehydrogenases; Region: PGDH; cd05288 313603008417 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 313603008418 NAD(P) binding site [chemical binding]; other site 313603008419 substrate binding site [chemical binding]; other site 313603008420 dimer interface [polypeptide binding]; other site 313603008421 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 313603008422 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 313603008423 substrate binding site [chemical binding]; other site 313603008424 oxyanion hole (OAH) forming residues; other site 313603008425 trimer interface [polypeptide binding]; other site 313603008426 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 313603008427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603008428 NAD(P) binding site [chemical binding]; other site 313603008429 active site 313603008430 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 313603008431 Phosphotransferase enzyme family; Region: APH; pfam01636 313603008432 putative active site [active] 313603008433 putative substrate binding site [chemical binding]; other site 313603008434 ATP binding site [chemical binding]; other site 313603008435 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 313603008436 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 313603008437 active site 313603008438 short chain dehydrogenase; Provisional; Region: PRK07035 313603008439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603008440 NAD(P) binding site [chemical binding]; other site 313603008441 active site 313603008442 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 313603008443 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 313603008444 active site 313603008445 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 313603008446 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 313603008447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 313603008448 Cytochrome c; Region: Cytochrom_C; cl11414 313603008449 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 313603008450 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 313603008451 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 313603008452 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 313603008453 active site 313603008454 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603008455 Sulfatase; Region: Sulfatase; pfam00884 313603008456 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603008457 Sulfatase; Region: Sulfatase; cl17466 313603008458 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 313603008459 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 313603008460 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 313603008461 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 313603008462 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 313603008463 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 313603008464 active site 313603008465 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 313603008466 putative active cleft [active] 313603008467 dimerization interface [polypeptide binding]; other site 313603008468 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 313603008469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603008470 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603008471 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603008472 Ferredoxin [Energy production and conversion]; Region: COG1146 313603008473 4Fe-4S binding domain; Region: Fer4; cl02805 313603008474 4Fe-4S binding domain; Region: Fer4; pfam00037 313603008475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 313603008476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 313603008477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 313603008478 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 313603008479 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 313603008480 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 313603008481 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 313603008482 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 313603008483 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 313603008484 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 313603008485 Protein export membrane protein; Region: SecD_SecF; cl14618 313603008486 Protein export membrane protein; Region: SecD_SecF; cl14618 313603008487 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 313603008488 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 313603008489 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 313603008490 HlyD family secretion protein; Region: HlyD_3; pfam13437 313603008491 Outer membrane efflux protein; Region: OEP; pfam02321 313603008492 Outer membrane efflux protein; Region: OEP; pfam02321 313603008493 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 313603008494 active site 313603008495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 313603008496 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 313603008497 Subunit I/III interface [polypeptide binding]; other site 313603008498 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 313603008499 metal ion-dependent adhesion site (MIDAS); other site 313603008500 MoxR-like ATPases [General function prediction only]; Region: COG0714 313603008501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603008502 Walker A motif; other site 313603008503 ATP binding site [chemical binding]; other site 313603008504 Walker B motif; other site 313603008505 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 313603008506 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 313603008507 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 313603008508 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 313603008509 Hemerythrin-like domain; Region: Hr-like; cd12108 313603008510 Fe binding site [ion binding]; other site 313603008511 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 313603008512 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 313603008513 Cu(I) binding site [ion binding]; other site 313603008514 Uncharacterized conserved protein [Function unknown]; Region: COG1262 313603008515 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 313603008516 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 313603008517 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 313603008518 Multicopper oxidase; Region: Cu-oxidase; pfam00394 313603008519 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 313603008520 Cytochrome c; Region: Cytochrom_C; pfam00034 313603008521 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 313603008522 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 313603008523 Binuclear center (active site) [active] 313603008524 Putative proton exit pathway; other site 313603008525 Cytochrome c; Region: Cytochrom_C; pfam00034 313603008526 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603008527 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603008528 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 313603008529 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 313603008530 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 313603008531 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 313603008532 DsrC like protein; Region: DsrC; pfam04358 313603008533 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 313603008534 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 313603008535 sulfite oxidase; Provisional; Region: PLN00177 313603008536 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 313603008537 Moco binding site; other site 313603008538 metal coordination site [ion binding]; other site 313603008539 dimerization interface [polypeptide binding]; other site 313603008540 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 313603008541 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 313603008542 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 313603008543 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 313603008544 metal-binding site [ion binding] 313603008545 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603008546 active site residue [active] 313603008547 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 313603008548 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603008549 active site residue [active] 313603008550 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 313603008551 active site residue [active] 313603008552 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 313603008553 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 313603008554 ligand binding site [chemical binding]; other site 313603008555 flexible hinge region; other site 313603008556 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 313603008557 non-specific DNA interactions [nucleotide binding]; other site 313603008558 DNA binding site [nucleotide binding] 313603008559 sequence specific DNA binding site [nucleotide binding]; other site 313603008560 putative cAMP binding site [chemical binding]; other site 313603008561 hypothetical protein; Provisional; Region: PRK06148 313603008562 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 313603008563 active site 313603008564 ATP binding site [chemical binding]; other site 313603008565 substrate binding site [chemical binding]; other site 313603008566 Peptidase family M23; Region: Peptidase_M23; pfam01551 313603008567 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 313603008568 inhibitor-cofactor binding pocket; inhibition site 313603008569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 313603008570 catalytic residue [active] 313603008571 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 313603008572 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 313603008573 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 313603008574 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 313603008575 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 313603008576 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 313603008577 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 313603008578 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603008579 catalytic residue [active] 313603008580 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 313603008581 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 313603008582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603008583 active site 313603008584 phosphorylation site [posttranslational modification] 313603008585 intermolecular recognition site; other site 313603008586 dimerization interface [polypeptide binding]; other site 313603008587 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 313603008588 DNA binding residues [nucleotide binding] 313603008589 dimerization interface [polypeptide binding]; other site 313603008590 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 313603008591 Sporulation related domain; Region: SPOR; pfam05036 313603008592 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 313603008593 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 313603008594 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 313603008595 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 313603008596 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 313603008597 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 313603008598 active site 313603008599 intersubunit interface [polypeptide binding]; other site 313603008600 catalytic residue [active] 313603008601 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 313603008602 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 313603008603 substrate binding site [chemical binding]; other site 313603008604 ATP binding site [chemical binding]; other site 313603008605 Transcriptional regulators [Transcription]; Region: PurR; COG1609 313603008606 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 313603008607 DNA binding site [nucleotide binding] 313603008608 domain linker motif; other site 313603008609 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 313603008610 dimerization interface [polypeptide binding]; other site 313603008611 ligand binding site [chemical binding]; other site 313603008612 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 313603008613 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 313603008614 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 313603008615 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 313603008616 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 313603008617 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 313603008618 Zn2+ binding site [ion binding]; other site 313603008619 Mg2+ binding site [ion binding]; other site 313603008620 acetyl-CoA C-acetyltransferase; Region: PLN02644 313603008621 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 313603008622 dimer interface [polypeptide binding]; other site 313603008623 active site 313603008624 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 313603008625 NlpC/P60 family; Region: NLPC_P60; cl17555 313603008626 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 313603008627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603008628 binding surface 313603008629 TPR motif; other site 313603008630 TPR repeat; Region: TPR_11; pfam13414 313603008631 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603008632 binding surface 313603008633 TPR motif; other site 313603008634 DNA gyrase subunit A; Validated; Region: PRK05560 313603008635 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 313603008636 CAP-like domain; other site 313603008637 active site 313603008638 primary dimer interface [polypeptide binding]; other site 313603008639 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 313603008640 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 313603008641 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 313603008642 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 313603008643 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 313603008644 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 313603008645 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 313603008646 Clp amino terminal domain; Region: Clp_N; pfam02861 313603008647 Clp amino terminal domain; Region: Clp_N; pfam02861 313603008648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603008649 Walker A motif; other site 313603008650 ATP binding site [chemical binding]; other site 313603008651 Walker B motif; other site 313603008652 arginine finger; other site 313603008653 UvrB/uvrC motif; Region: UVR; pfam02151 313603008654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603008655 Walker A motif; other site 313603008656 ATP binding site [chemical binding]; other site 313603008657 Walker B motif; other site 313603008658 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 313603008659 putative carbohydrate kinase; Provisional; Region: PRK10565 313603008660 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 313603008661 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 313603008662 putative substrate binding site [chemical binding]; other site 313603008663 putative ATP binding site [chemical binding]; other site 313603008664 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 313603008665 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 313603008666 putative catalytic residues [active] 313603008667 nucleotide binding site [chemical binding]; other site 313603008668 aspartate binding site [chemical binding]; other site 313603008669 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 313603008670 dimer interface [polypeptide binding]; other site 313603008671 putative threonine allosteric regulatory site; other site 313603008672 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 313603008673 putative threonine allosteric regulatory site; other site 313603008674 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 313603008675 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 313603008676 homoserine kinase; Provisional; Region: PRK01212 313603008677 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 313603008678 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 313603008679 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 313603008680 threonine synthase; Validated; Region: PRK09225 313603008681 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603008682 catalytic residue [active] 313603008683 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 313603008684 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 313603008685 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 313603008686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 313603008687 NAD(P) binding site [chemical binding]; other site 313603008688 active site 313603008689 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 313603008690 aromatic arch; other site 313603008691 DCoH dimer interaction site [polypeptide binding]; other site 313603008692 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 313603008693 DCoH tetramer interaction site [polypeptide binding]; other site 313603008694 substrate binding site [chemical binding]; other site 313603008695 hypothetical protein; Provisional; Region: PRK12378 313603008696 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 313603008697 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 313603008698 putative acyl-acceptor binding pocket; other site 313603008699 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 313603008700 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 313603008701 active site 313603008702 NAD binding site [chemical binding]; other site 313603008703 metal binding site [ion binding]; metal-binding site 313603008704 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 313603008705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 313603008706 motif II; other site 313603008707 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 313603008708 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 313603008709 Ligand binding site; other site 313603008710 oligomer interface; other site 313603008711 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 313603008712 AAA domain; Region: AAA_30; pfam13604 313603008713 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 313603008714 Family description; Region: UvrD_C_2; pfam13538 313603008715 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 313603008716 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 313603008717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603008718 S-adenosylmethionine binding site [chemical binding]; other site 313603008719 Amidinotransferase; Region: Amidinotransf; cl12043 313603008720 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 313603008721 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 313603008722 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 313603008723 active site 313603008724 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 313603008725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603008726 Walker A motif; other site 313603008727 ATP binding site [chemical binding]; other site 313603008728 Walker B motif; other site 313603008729 arginine finger; other site 313603008730 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 313603008731 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 313603008732 active site 313603008733 dinuclear metal binding site [ion binding]; other site 313603008734 dimerization interface [polypeptide binding]; other site 313603008735 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 313603008736 catalytic core [active] 313603008737 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 313603008738 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 313603008739 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 313603008740 ribonuclease Z; Reviewed; Region: PRK00055 313603008741 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 313603008742 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 313603008743 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 313603008744 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 313603008745 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 313603008746 active site 313603008747 two-component response regulator; Provisional; Region: PRK14084 313603008748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603008749 active site 313603008750 phosphorylation site [posttranslational modification] 313603008751 intermolecular recognition site; other site 313603008752 dimerization interface [polypeptide binding]; other site 313603008753 LytTr DNA-binding domain; Region: LytTR; smart00850 313603008754 Histidine kinase; Region: His_kinase; pfam06580 313603008755 Galactose oxidase, central domain; Region: Kelch_3; cl02701 313603008756 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 313603008757 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 313603008758 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 313603008759 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 313603008760 RNA binding site [nucleotide binding]; other site 313603008761 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 313603008762 RNA binding site [nucleotide binding]; other site 313603008763 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 313603008764 RNA binding site [nucleotide binding]; other site 313603008765 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 313603008766 RNA binding site [nucleotide binding]; other site 313603008767 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 313603008768 RNA binding site [nucleotide binding]; other site 313603008769 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 313603008770 RNA binding site [nucleotide binding]; other site 313603008771 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 313603008772 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 313603008773 cytidylate kinase; Provisional; Region: cmk; PRK00023 313603008774 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 313603008775 CMP-binding site; other site 313603008776 The sites determining sugar specificity; other site 313603008777 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 313603008778 Found in ATP-dependent protease La (LON); Region: LON; smart00464 313603008779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603008780 Walker A motif; other site 313603008781 ATP binding site [chemical binding]; other site 313603008782 Walker B motif; other site 313603008783 arginine finger; other site 313603008784 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 313603008785 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 313603008786 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603008787 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603008788 DNA binding residues [nucleotide binding] 313603008789 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 313603008790 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 313603008791 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 313603008792 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 313603008793 Peptidase family M48; Region: Peptidase_M48; pfam01435 313603008794 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 313603008795 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 313603008796 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 313603008797 trimer interface [polypeptide binding]; other site 313603008798 active site 313603008799 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 313603008800 catalytic site [active] 313603008801 glycogen branching enzyme; Provisional; Region: PRK12313 313603008802 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 313603008803 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 313603008804 active site 313603008805 catalytic site [active] 313603008806 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 313603008807 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 313603008808 SelR domain; Region: SelR; pfam01641 313603008809 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 313603008810 DinB superfamily; Region: DinB_2; pfam12867 313603008811 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 313603008812 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 313603008813 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 313603008814 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 313603008815 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 313603008816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 313603008817 integral membrane protein; Region: integ_memb_HG; TIGR03954 313603008818 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 313603008819 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 313603008820 homotrimer interaction site [polypeptide binding]; other site 313603008821 putative active site [active] 313603008822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603008823 Coenzyme A binding pocket [chemical binding]; other site 313603008824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 313603008825 Coenzyme A binding pocket [chemical binding]; other site 313603008826 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 313603008827 active site 313603008828 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603008829 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603008830 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603008831 Sulfatase; Region: Sulfatase; pfam00884 313603008832 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 313603008833 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 313603008834 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 313603008835 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 313603008836 Dehydroquinase class II; Region: DHquinase_II; pfam01220 313603008837 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 313603008838 active site 313603008839 trimer interface [polypeptide binding]; other site 313603008840 dimer interface [polypeptide binding]; other site 313603008841 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 313603008842 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 313603008843 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 313603008844 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 313603008845 active site 313603008846 Int/Topo IB signature motif; other site 313603008847 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 313603008848 active site 313603008849 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 313603008850 amidohydrolase; Region: amidohydrolases; TIGR01891 313603008851 putative metal binding site [ion binding]; other site 313603008852 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 313603008853 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603008854 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 313603008855 DNA binding residues [nucleotide binding] 313603008856 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 313603008857 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 313603008858 putative acyl-acceptor binding pocket; other site 313603008859 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 313603008860 putative active site [active] 313603008861 putative CoA binding site [chemical binding]; other site 313603008862 nudix motif; other site 313603008863 metal binding site [ion binding]; metal-binding site 313603008864 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 313603008865 active site 313603008866 Predicted membrane protein [Function unknown]; Region: COG2860 313603008867 UPF0126 domain; Region: UPF0126; pfam03458 313603008868 UPF0126 domain; Region: UPF0126; pfam03458 313603008869 RDD family; Region: RDD; pfam06271 313603008870 Integral membrane protein DUF95; Region: DUF95; pfam01944 313603008871 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 313603008872 MoxR-like ATPases [General function prediction only]; Region: COG0714 313603008873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 313603008874 Walker A motif; other site 313603008875 ATP binding site [chemical binding]; other site 313603008876 Walker B motif; other site 313603008877 arginine finger; other site 313603008878 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 313603008879 Protein of unknown function DUF58; Region: DUF58; pfam01882 313603008880 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 313603008881 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 313603008882 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 313603008883 Predicted esterase [General function prediction only]; Region: COG0400 313603008884 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 313603008885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603008886 S-adenosylmethionine binding site [chemical binding]; other site 313603008887 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603008888 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603008889 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 313603008890 catalytic residues [active] 313603008891 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 313603008892 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 313603008893 active site 313603008894 catalytic tetrad [active] 313603008895 CAAX protease self-immunity; Region: Abi; pfam02517 313603008896 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 313603008897 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 313603008898 Bor protein; Region: Lambda_Bor; pfam06291 313603008899 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 313603008900 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 313603008901 active site 313603008902 catalytic triad [active] 313603008903 dimer interface [polypeptide binding]; other site 313603008904 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603008905 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603008906 CAAX protease self-immunity; Region: Abi; pfam02517 313603008907 TfoX C-terminal domain; Region: TfoX_C; pfam04994 313603008908 Domain of unknown function DUF87; Region: DUF87; pfam01935 313603008909 AAA-like domain; Region: AAA_10; pfam12846 313603008910 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 313603008911 FRG domain; Region: FRG; pfam08867 313603008912 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 313603008913 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 313603008914 putative NAD(P) binding site [chemical binding]; other site 313603008915 putative oxidoreductase; Provisional; Region: PRK11579 313603008916 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603008917 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 313603008918 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 313603008919 Sulfatase; Region: Sulfatase; pfam00884 313603008920 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 313603008921 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 313603008922 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 313603008923 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 313603008924 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 313603008925 Predicted transcriptional regulator [Transcription]; Region: COG2378 313603008926 HTH domain; Region: HTH_11; pfam08279 313603008927 WYL domain; Region: WYL; pfam13280 313603008928 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 313603008929 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 313603008930 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 313603008931 CoenzymeA binding site [chemical binding]; other site 313603008932 subunit interaction site [polypeptide binding]; other site 313603008933 PHB binding site; other site 313603008934 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603008935 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603008936 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 313603008937 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 313603008938 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 313603008939 GAF domain; Region: GAF; pfam01590 313603008940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 313603008941 dimer interface [polypeptide binding]; other site 313603008942 phosphorylation site [posttranslational modification] 313603008943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603008944 ATP binding site [chemical binding]; other site 313603008945 Mg2+ binding site [ion binding]; other site 313603008946 G-X-G motif; other site 313603008947 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 313603008948 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 313603008949 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 313603008950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 313603008951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 313603008952 dimer interface [polypeptide binding]; other site 313603008953 phosphorylation site [posttranslational modification] 313603008954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603008955 ATP binding site [chemical binding]; other site 313603008956 Mg2+ binding site [ion binding]; other site 313603008957 G-X-G motif; other site 313603008958 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 313603008959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 313603008960 active site 313603008961 phosphorylation site [posttranslational modification] 313603008962 intermolecular recognition site; other site 313603008963 dimerization interface [polypeptide binding]; other site 313603008964 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 313603008965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 313603008966 HEAT repeats; Region: HEAT_2; pfam13646 313603008967 Methyltransferase domain; Region: Methyltransf_31; pfam13847 313603008968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 313603008969 S-adenosylmethionine binding site [chemical binding]; other site 313603008970 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 313603008971 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603008972 catalytic residue [active] 313603008973 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 313603008974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 313603008975 TPR motif; other site 313603008976 binding surface 313603008977 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 313603008978 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 313603008979 Cu(I) binding site [ion binding]; other site 313603008980 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 313603008981 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 313603008982 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 313603008983 HEAT repeats; Region: HEAT_2; pfam13646 313603008984 protein binding surface [polypeptide binding]; other site 313603008985 HEAT repeats; Region: HEAT_2; pfam13646 313603008986 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 313603008987 pyruvate kinase; Provisional; Region: PRK14725 313603008988 active site 313603008989 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 313603008990 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 313603008991 FMN binding site [chemical binding]; other site 313603008992 substrate binding site [chemical binding]; other site 313603008993 putative catalytic residue [active] 313603008994 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 313603008995 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 313603008996 Ligand Binding Site [chemical binding]; other site 313603008997 Immunoglobulin I-set domain; Region: I-set; pfam07679 313603008998 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 313603008999 membrane protein insertase; Provisional; Region: PRK01318 313603009000 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 313603009001 CTP synthetase; Validated; Region: pyrG; PRK05380 313603009002 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 313603009003 Catalytic site [active] 313603009004 active site 313603009005 UTP binding site [chemical binding]; other site 313603009006 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 313603009007 active site 313603009008 putative oxyanion hole; other site 313603009009 catalytic triad [active] 313603009010 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 313603009011 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 313603009012 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 313603009013 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 313603009014 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 313603009015 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 313603009016 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 313603009017 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 313603009018 ligand binding site [chemical binding]; other site 313603009019 GMP synthase; Reviewed; Region: guaA; PRK00074 313603009020 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 313603009021 AMP/PPi binding site [chemical binding]; other site 313603009022 candidate oxyanion hole; other site 313603009023 catalytic triad [active] 313603009024 potential glutamine specificity residues [chemical binding]; other site 313603009025 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 313603009026 ATP Binding subdomain [chemical binding]; other site 313603009027 Ligand Binding sites [chemical binding]; other site 313603009028 Dimerization subdomain; other site 313603009029 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 313603009030 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 313603009031 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 313603009032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 313603009033 catalytic residue [active] 313603009034 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 313603009035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 313603009036 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 313603009037 putative active site [active] 313603009038 Zn binding site [ion binding]; other site 313603009039 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1; cd01653 313603009040 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 313603009041 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 313603009042 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 313603009043 fructuronate transporter; Provisional; Region: PRK10034; cl15264 313603009044 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 313603009045 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 313603009046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 313603009047 FeS/SAM binding site; other site 313603009048 Beta-lactamase; Region: Beta-lactamase; pfam00144 313603009049 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 313603009050 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 313603009051 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 313603009052 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 313603009053 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 313603009054 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 313603009055 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 313603009056 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 313603009057 competence damage-inducible protein A; Provisional; Region: PRK00549 313603009058 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 313603009059 putative MPT binding site; other site 313603009060 Competence-damaged protein; Region: CinA; pfam02464 313603009061 Hpt domain; Region: Hpt; pfam01627 313603009062 putative binding surface; other site 313603009063 active site 313603009064 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 313603009065 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 313603009066 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603009067 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 313603009068 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 313603009069 active site 313603009070 catalytic site [active] 313603009071 substrate binding site [chemical binding]; other site 313603009072 Protein of unknown function, DUF481; Region: DUF481; cl01213 313603009073 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 313603009074 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 313603009075 E3 interaction surface; other site 313603009076 lipoyl attachment site [posttranslational modification]; other site 313603009077 e3 binding domain; Region: E3_binding; pfam02817 313603009078 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 313603009079 recombination protein RecR; Reviewed; Region: recR; PRK00076 313603009080 RecR protein; Region: RecR; pfam02132 313603009081 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 313603009082 putative active site [active] 313603009083 putative metal-binding site [ion binding]; other site 313603009084 tetramer interface [polypeptide binding]; other site 313603009085 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 313603009086 Na binding site [ion binding]; other site 313603009087 CoA binding domain; Region: CoA_binding_2; pfam13380 313603009088 Cna protein B-type domain; Region: Cna_B_2; pfam13715 313603009089 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 313603009090 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 313603009091 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 313603009092 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 313603009093 dimer interface [polypeptide binding]; other site 313603009094 active site 313603009095 CoA binding pocket [chemical binding]; other site 313603009096 heat shock protein 90; Provisional; Region: PRK05218 313603009097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 313603009098 ATP binding site [chemical binding]; other site 313603009099 Mg2+ binding site [ion binding]; other site 313603009100 G-X-G motif; other site 313603009101 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 313603009102 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 313603009103 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 313603009104 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 313603009105 Family of unknown function (DUF706); Region: DUF706; pfam05153 313603009106 putative transporter; Provisional; Region: PRK10484 313603009107 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 313603009108 Na binding site [ion binding]; other site 313603009109 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 313603009110 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 313603009111 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 313603009112 DNA binding residues [nucleotide binding] 313603009113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 313603009114 MOSC domain; Region: MOSC; pfam03473 313603009115 Cupin domain; Region: Cupin_2; cl17218 313603009116 Helix-turn-helix domain; Region: HTH_18; pfam12833 313603009117 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 313603009118 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 313603009119 active site 313603009120 Zn binding site [ion binding]; other site 313603009121 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 313603009122 putative ligand binding site [chemical binding]; other site 313603009123 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 313603009124 putative ligand binding site [chemical binding]; other site 313603009125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 313603009126 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 313603009127 active site 313603009128 motif I; other site 313603009129 motif II; other site 313603009130 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 313603009131 Protein of unknown function (DUF819); Region: DUF819; cl02317 313603009132 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 313603009133 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 313603009134 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cd12213 313603009135 ligand binding site [chemical binding]; other site 313603009136 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 313603009137 active site 313603009138 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 313603009139 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 313603009140 active site 313603009141 metal binding site [ion binding]; metal-binding site 313603009142 nudix motif; other site 313603009143 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 313603009144 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585