-- dump date 20111121_012228 -- class Genbank::CDS -- table cds_note -- id note YP_001294941.1 Similar to chromosome segregation ATPases Cytophaga hutchinsonii. Probable transmembrane protein YP_001294942.1 Similar to predicted metal-dependent hydrolase COG0319 YP_001294943.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001294945.1 Weakly similar to outer membrane protein (OmpH- like) pfam03938 YP_001294946.1 Some similarities with PKD repeats protein of Cytophaga hutchinsonii YP_001294947.1 Similar to putative helicase of Porphyromonas gingivalis and Cytophaga hutchinsonii YP_001294948.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001294949.1 Similar to cAMP-binding proteins - catabolite geneactivator and regulatory subunit of cAMP-dependent protein kinase COG0664 YP_001294950.1 Probable transmembrane protein YP_001294951.1 Similar to HolB ATPase involved in DNA replicationCOG0470 YP_001294952.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001294953.1 Similar to proteins of unknown function of the CFBphylum YP_001294954.1 Putative adhesin precursor likely involved in gliding motility YP_001294955.1 Putative cell surface protein likely involved in gliding motility YP_001294956.1 Putative adhesin precursor likely involved in gliding motility YP_001294957.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Porphyromonas gingivalis YP_001294958.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001294959.1 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity) YP_001294960.1 Similar to predicted acyltransferase ElaA COG2153 YP_001294961.1 Similar to outer membrane protein and related peptidoglycan-associated (lipo)proteins COG2885 YP_001294962.1 Similar to protein of unknown function YceA of E. coli YP_001294963.1 Similar to Fjo17 protein of Flavobacterium johnsoniae YP_001294964.1 In Flavobacterium johnsoniae, GldH is a lipoprotein that is required for gliding motility and chitin utilization YP_001294965.1 Peptidoglycan synthesis; final stages (by similarity) YP_001294966.1 Short-chain fatty acids metabolism YP_001294967.1 Similar to putative type I restriction-modification system, M subunit, of Porphyromonas gingivalis YP_001294970.1 Short-chain fatty acids metabolism YP_001294971.1 Similar to uncharacterized membrane protein YP_001294972.1 Similar to predicted 3'-5' exonuclease related to the exonuclease domain of PolB, WlaX protein of Campylobacter jejuni. YP_001294973.1 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairsalkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Can also repair O-4-methylthymine (by similarity) YP_001294974.1 Similar to cytochrome c551/c552 COG4654 YP_001294975.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001294976.1 Similar to protein of unknown function of Bacteroides thetaiotaomicron YP_001294977.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_001294979.1 Acetylation of N-terminal amino-acid of ribosomal protein YP_001294980.1 Some weak similarities to proteins of unknown function YP_001294981.1 Similar to eukaryotic uroporphyrinogen decarboxylase COG0407 YP_001294982.1 Porphyrin biosynthesis; fourth step (by similarity) YP_001294983.1 Porphobilinogen deaminase. Porphyrin biosynthesis by the C5 pathway; fourth step (by similarity) YP_001294984.1 Porphyrin biosynthesis by the C5 pathway; first step (by similarity) YP_001294986.1 Protoheme biosynthesis; last step (by similarity) YP_001294987.1 Similar to predicted membrane protein COG1981 YP_001294989.1 Butyrate/butanol-producing pathway YP_001294990.1 Similar to predicted HD superfamily hydrolase COG1418 YP_001294991.1 Similar to eukaryotic acyl-[acyl-carrier-protein] desaturase YP_001294992.1 De novo phospholipid biosynthesis; second step. Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-acyl carrier protein as the fatty acyl donor (by similarity) YP_001294993.1 Similar to protein of unknown function YqiW of B. subtilis YP_001294994.1 Similar to predicted hydrolase (HAD superfamily) COG1011 YP_001294995.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001294997.1 Probable transmembrane protein YP_001294998.1 Similar to uncharacterized proteins, homologs of microcin C7 resistance protein MccF COG1619 YP_001294999.1 Similar to predicted endonuclease distantly related to archaeal Holliday junction resolvase COG0792 YP_001295000.1 Similar to predicted oxidoreductases (related to aryl-alcohol dehydrogenases) COG0667 YP_001295001.1 Probable outer membrane lipoprotein YP_001295002.1 Exonucleolytic cleavage in the 3'- to 5'- directionto yield nucleoside 5'-phosphates (by similarity) YP_001295003.1 Similar to putative hemolysin of Vibrio sp. YP_001295004.1 Similar to eukaryotic and archaeal phosphoglycerate dehydrogenases YP_001295005.1 Probable transmembrane protein YP_001295006.1 Proline biosynthesis; third (last) step (by similarity) YP_001295007.1 Similar to Mg/Co/Ni transporter MgtE (contains CBSdomain) COG2239. Probable transmembrane protein YP_001295008.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001295009.1 Similar to abortive infection bacteriophage resistance protein COG4823 YP_001295010.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Bacteroides thetaiotaomicron YP_001295011.1 Similar to TPR repeat protein of Cytophaga hutchinsonii YP_001295012.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001295013.1 Some similarities with protein of unknown function YP_001295014.1 Weakly similar to putative Rieske-FeS protein YP_001295015.1 Similar to predicted thiol oxidoreductase COG3488. YP_001295016.1 N-terminal region similar to similar to probable manganese transport protein MntH and C-terminal region similar to universal stress protein YP_001295017.1 Iron-dependant repressor YP_001295018.1 Some similarities with protein of unknown functionof Colwellia psychrerythraea and Shewanella oneidensis YP_001295019.1 Some similarities with predicted proline hydroxylase COG3751 YP_001295020.1 Similar to predicted membrane-associated Zn- dependent proteases 1 COG0750 YP_001295021.1 Some similarities with aminopeptidase N COG0308 YP_001295022.1 Some similarities with single-strand DNA-binding protein Ssb YP_001295024.1 Similar to putative enzyme of sugar metabolism YeeZ of Escherichia coli YP_001295025.1 Endopeptidase with broad substrate specificity forseveral oligopeptides (by similarity) YP_001295026.1 Similar to glycosyl hydrolases YP_001295027.1 Start doubtful, the first ATG was choosen. Similarto uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems COG1999 YP_001295028.1 Involved in ferrous ion uptake YP_001295029.1 Probable GTP-driven transporter of ferrous ion (bysimilarity) YP_001295031.1 Tricarboxylic acid cycle. Part of an enzyme complex containing three subunits: a flavoprotein (SdhA), an iron- sulfur protein (SdhB) and cytochrome b (SdhC) YP_001295032.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001295034.1 Tricarboxylic acid cycle. Part of an enzyme complex containing three subunits: a flavoprotein (SdhA), an iron- sulfur protein (SdhB) and cytochrome b (SdhC) YP_001295035.1 Putative lipoprotein YP_001295036.1 Probable lipoprotein, some similarities with suilysin protein of Streptococcus suis and others thiol- activated cytolysin YP_001295037.1 Some weak similarities with outer membrane receptor proteins YP_001295038.1 Peptidoglycan synthesis; final stages (by similarity) YP_001295040.1 Similar to protein of unknown function of Geobacter sulfurreducens and Nitrosomonas europaea YP_001295042.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001295043.1 Some similarities with predicted hydrolase of the alpha/beta superfamily COG2819 YP_001295044.1 Similar to predicted integral membrane protein COG0392 YP_001295045.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_001295046.1 Cofactor biosynthesis; pantothenate biosynthesis; pantothenate from beta-alanine and pantoate: single step [final step] (by similaity) YP_001295047.1 Some similarities with glycogen synthase COG0297 YP_001295048.1 Probable lipoprotein YP_001295049.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001295050.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001295051.1 Similar to putative outer membrane protein of Ornithobacterium rhinotracheale and Cytophaga hutchinsonii YP_001295052.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001295053.1 Produces ATP from ADP in the presence of a proton gradient across the membrane (by similarity) YP_001295054.1 Probable transmembrane protein YP_001295058.1 Some weak similarities with protein of unknown function of Cytophaga hutchinsonii YP_001295059.1 Some similarities with putative outer membrane protein PG57 of Porphyromonas gingivalis YP_001295060.1 Similar to Long-chain-fatty-acid--luciferin- component ligase (Acyl-protein synthetase) LuxE YP_001295061.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001295062.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001295063.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001295064.1 Similar to uncharacterized membrane protein, required for colicin V production of Psychrobacter sp. and Geobacter metallireducens YP_001295065.1 Similar to BatE protein of the Batl (Bacteroides aerotolerance) operon in Bacteroides fragilis. Probable transmembrane protein YP_001295066.1 Similar to BatD protein of the Batl (Bacteroides aerotolerance) operon in Bacteroides fragilis YP_001295067.1 Similar to BatC protein of the Batl (Bacteroides aerotolerance) operon in Bacteroides fragilis YP_001295068.1 Similar to BatB protein of the Batl (Bacteroides aerotolerance) operon in Bacteroides fragilis. Probable transmembrane protein YP_001295069.1 Similar to protein of unknown function YP_001295070.1 Similar to BatA protein of the Batl (Bacteroides aerotolerance) operon in Bacteroides fragilis. Probable transmembrane protein YP_001295071.1 Some similarities with protein of unknown functionof the CFB phylum. Probable transmembrane protein YP_001295073.1 Some similarities with uncharacterized conserved protein COG1721 YP_001295074.1 Similar to MoxR-like ATPases COG0714 YP_001295075.1 Some weak similarities with protein of unknown function of Crocosphaera watsonii YP_001295076.1 Serine/threonine protein phosphatase plays a key role in signaling protein misfolding (by similarity) YP_001295077.1 Probable exported protein YP_001295078.1 Similar to uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism COG2824 YP_001295079.1 De novo phospholipid biosynthesis; glycerol-3 phosphate formation (by similarity) YP_001295080.1 Similar to uncharacterized oxidoreductases, Fe- dependent alcohol dehydrogenase family COG1979 YP_001295081.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_001295082.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001295083.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001295084.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001295085.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001295086.1 Similar to acetylornithine deacetylase/succinyl- diaminopimelate desuccinylase and related deacylases COG0624 YP_001295087.1 Similar to phospholipid N-methyltransferase COG3963 YP_001295088.1 Weakly similar to protein of unknown function of Streptomyces avermitilis. Probable transmembrane protein YP_001295089.1 Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide ortripeptide (by similarity) YP_001295090.1 Similar to predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) COG0596 YP_001295091.1 Similar to protein of unknown function of the CFB phylum YP_001295092.1 Outer membrane protein (OmpA-like) COG2885 YP_001295093.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_001295094.1 Similar to uncharacterized protein conserved in bacteria YP_001295095.1 Similar to ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) COG1074 YP_001295096.1 Mn; manganese; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (bysimilarity) YP_001295098.1 Similar to nucleoside-diphosphate-sugar epimerasesCOG0451 and to putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes COG3320 YP_001295100.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides YP_001295117.1 Probable transmembrane protein YP_001295118.1 Similar to uroporphyrinogen-III synthase COG1587 YP_001295119.1 Similar to Enoyl-CoA hydratase/carnithine racemaseCOG1024 YP_001295120.1 Some similarities with protein chain release factor B COG1186 YP_001295121.1 N-terminal region similar to C-terminal region of transcriptional regulator NadR and C-terminal region similar to protein of unknown function of the CFB phylum YP_001295122.1 PnuC is an integral membrane protein required for NMN transport across the cytoplasmic membrane. It is believed to function cooperatively with NadR. TC : 4.B.1.1.Z YP_001295123.1 PcrB-like protein; GGGP synthase; member of prenyltransferases that transfer isoprenoid groups to nonisoprenoid acceptors; functions in form GGGP from glycerol-1-phosphate (G-1-P) and geranylgeranyl pyrophosphate (GGPP); important in lipid metabolism and especially important as the ether linkages in archaea are different than those in bacteria; GGGP synthase lies at the branch point for membrane lipid biosynthesis; cytosolic; T acidophilum protein acts as a homodimer while M thermoautotrophicum protein has been reported to function as a pentamer YP_001295124.1 Similar to phosphopantetheinyl transferase COG2091 YP_001295125.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_001295126.1 Start doubtful, the first ATG was choosen YP_001295127.1 Highly similar to psychrophilic and thermolabile L- threonine dehydrogenase from Flavobacterium frigidimaris strain KUC-1. Threonine catabolism YP_001295128.1 Necessary for strand-specific repair. A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically recognized byTRCF which releases RNAP and the truncated transcript; the TCRF may replace RNAP at the lesion site and then recruit the uvrA/B/C repair system (by similarity) YP_001295129.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Probable transmembrane protein YP_001295130.1 Probable pseudogene, C-terminal region similar to C- terminal region of rare lipoprotein A YP_001295131.1 Similar to uncharacterized protein conserved in bacteria COG2954 YP_001295132.1 De novo purine biosynthesis; first step YP_001295134.1 Endonuclease that specifically degrades the RNA ofRNA-DNA hybrids (by similarity) YP_001295135.1 De novo purine biosynthesis; third step YP_001295136.1 carries the fatty acid chain in fatty acid biosynthesis YP_001295137.1 Fatty acid biosynthesis YP_001295138.1 Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs (by similarity) YP_001295140.1 Glycolysis; final step YP_001295141.1 Some similarities with protein of unknown functionof Xanthomonas axonopodis YP_001295142.1 Similar to uncharacterized protein conserved in bacteria COG2315 YP_001295143.1 Similar to predicted metal-dependent hydrolase COG1878 YP_001295144.1 Porphyrin biosynthesis YP_001295145.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001295146.1 Probable transmembrane protein YP_001295147.1 Similar to glycosyltransferases , probably involved in cell wall biogenesis COG1215 YP_001295149.1 Similar to uncharacterized protein conserved in bacteria COG2839 . Probable transmembrane protein YP_001295151.1 Probable exported protein YP_001295152.1 Probable exported protein YP_001295153.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) YP_001295154.1 General stress protein YP_001295155.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001295157.1 Similar to predicted deacylase COG3608 YP_001295158.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001295159.1 Similar to putative patatin-like phospholipase of the CFB phylum YP_001295160.1 Amino Acid-Polyamine-Organocation (APC) Superfamily. TC 2.A.3.Y.Z YP_001295161.1 Catabolism of tyrosine; third step and catabolism of phenylalanine; fourth step (by similarity) YP_001295162.1 Tyrosine catabolism YP_001295163.1 Similar to protein of unknown function YP_001295164.1 Tryptophan metabolism YP_001295166.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001295167.1 Calcium-induced and growth-phase-dependent metalloprotease. Probable virulence factor, secreted protein. C-terminal region similar to psychrophilic metalloprotease Fpp2 YP_001295168.1 Probable virulence factor, secreted protein YP_001295170.1 Biotin biosynthesis; last step YP_001295172.1 Similar to lactoylglutathione lyase and related lyases COG0346 YP_001295173.1 Essential for efficient processing of 16S rRNA. Probably part of the 30S subunit prior to or during the final step in the processing of 16S free 30S ribosomal subunits. Could be some accessory protein needed for efficient assembly of the 30S subunit. May interact with the 5'terminal helix region of 16S rRNA. Has affinity for free ribosomal 30S subunits but not for 70S ribosomes (by simialrity) YP_001295174.1 ABC transporter, permease (IM), o228-family, import of unknown substrat, TC 3.A.1.Y.Z YP_001295175.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001295176.1 Aromatic amino acids biosynthesis; shikimate pathway; sixth step YP_001295177.1 Similar to predicted pyrophosphatase COG1694 YP_001295178.1 Similar to predicted endonuclease containing a URIdomain COG2827 YP_001295182.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001295183.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_001295185.1 Similar to aspartate/tyrosine/aromatic aminotransferase COG0436 YP_001295186.1 L-phenylalanine biosynthesis YP_001295187.1 Highly similar to gliding motility protein GldA ofFlavobacterium johnsoniae. ABC transporter, ATP-binding protein (ABC), DRI-family, DRB-subfamily, export of unknownsubstrat, TC 3.A.1.Y.Z YP_001295188.1 Similar to YbfI protein of B. subtilis YP_001295190.1 Amino-acid biosynthesis YP_001295191.1 Amino-acid biosynthesis; L-methionine biosynthesis; O-acetyl-L-homoserine from L-homoserine: single step (bysimilarity) YP_001295192.1 Similar to O-acetylhomoserine sulfhydrylase COG2873 YP_001295193.1 Some similarities with uncharacterized conserved protein COG1721 YP_001295194.1 Thioredoxins are small disulphide-containing redoxproteins that serves as a general protein disulphide oxidoreductase YP_001295195.1 Probable exported protein YP_001295196.1 Similar to deoxynucleoside kinases COG1428 YP_001295198.1 Probable exported protein YP_001295199.1 Some weak similarities with putative outer membrane proteins YP_001295200.1 Similar to protein of unknown function of Porphyromonas gingivalis YP_001295201.1 Similar to protein of unknown function of the CFB phylum YP_001295202.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001295203.1 Involved in DNA repair and recF pathway recombination (by similarity) YP_001295204.1 Similar to the immunoreactive 84kD antigen PG93 ofPorphyromonas gingivalis YP_001295205.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_001295207.1 Similar to protein of unknown function YP_001295208.1 Some similarities with thiol-disulfide isomerase and thioredoxins COG0526 YP_001295209.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001295210.1 Similar to cold shock proteins COG1278 YP_001295211.1 Similar to cytosine/adenosine deaminases COG0590 YP_001295212.1 Some similarities with proteins of unknown function of Cytophaga hutchinsonii YP_001295213.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001295214.1 Highly similar to probable metalloprotease of Flavobacterium psychrophilum. Some similarities with fungi metalloproteases YP_001295215.1 Highly similar to probable metalloprotease of Flavobacterium psychrophilum. Some similarities with fungi metalloproteases YP_001295216.1 dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs (by similarity) YP_001295219.1 Putative lipoprotein YP_001295221.1 Probably involved in peptidoglycan modification (by similarity) YP_001295222.1 In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity.It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template (by similarity) YP_001295223.1 Some similarities with predicted phosphohydrolasesCOG1408. Probable transmembrane protein YP_001295224.1 Thioredoxins are small disulphide-containing redoxproteins that serves as a general protein disulphide oxidoreductase YP_001295225.1 Similar to predicted xylanase/chitin deacetylase COG0726 YP_001295226.1 Similar to hypothetical transport permease YbhR ofE. coli. ABC transporter, permease (IM), DRI-family, YHIH-subfamily, drug export (putative), TC 3.A.1.Y.Z YP_001295227.1 ABC transporter, membrane fusion protein (MFP), DRI- family, YHIH-subfamily, drug export (putative). Probablelipoprotein. TC 8.A.1.Y.Z YP_001295228.1 Outer Membrane Factor (OMF) Family. TC 1.B.17.Y.Z YP_001295229.1 Similar to protein of unknown function of the CFB phylum. Probable transmembrane protein YP_001295230.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_001295231.1 Similar to putative metalloprotease YggG of E. coli that seems to regulate the expression of speB YP_001295232.1 Similar to N-acetyltransferase YP_001295234.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Probable exported protein YP_001295236.1 Some similarities with alpha-amylases YP_001295239.1 Similar to predicted flavoproteins COG2081 YP_001295240.1 Similar to tryptophan-rich sensory protein COG3476 YP_001295244.1 Similar to mevalonate kinase COG1577 YP_001295245.1 Similar to 4-hydroxybenzoate polyprenyltransferaseand related prenyltransferases COG0382. Probable transmembrane protein YP_001295246.1 Similar to 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases COG1187 YP_001295247.1 Similar to protein of unknown function YP_001295248.1 Some similarities with Helix-turn-helix XRE- familylike proteins (xenobiotic response element family of transcriptional regulators) YP_001295250.1 Probable exported protein YP_001295251.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Porphyromonas gingivalis YP_001295252.1 Similar to immunogenic 75 kDa protein PG4 of Porphyromonas gingivalis YP_001295253.1 Long-chain fatty acid biosynthesis; first step. This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA (By similarity) YP_001295254.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_001295255.1 Similar to outer membrane protein/protective antigen OMA87 COG4775 YP_001295256.1 Similar to rRNA methylases COG0566 YP_001295257.1 Similar to PorT proteina membrane-associated Protein that influences transport/maturation of gingipains and adhesins of Porphyromonas gingivalis. TC 1.B.44.1.1 YP_001295258.1 Ubiquinone biosynthesis and Menaquinone biosynthesis; last step (by similarity) YP_001295259.1 Essential step for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (by similarity) YP_001295260.1 Probable transmembrane protein YP_001295261.1 Weakly similar to to proteins of unknown function of the CFB phylum. Probable exported protein YP_001295262.1 Similar to protein of unknown function of Porphyromonas gingivalis YP_001295264.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_001295265.1 Similar to uncharacterized conserved protein COG1259 YP_001295266.1 The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity) YP_001295267.1 The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity) YP_001295268.1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity) YP_001295269.1 Similar to protein of unknown function of the CFB phylum YP_001295270.1 Energy Metabolism; Oxidative phosphorylation YP_001295271.1 Similar to uncharacterized proteins, homologs of microcin C7 resistance protein MccF COG1619 YP_001295272.1 DNA polymerase III is a complex, multichain enzymeresponsible for most of the replicative synthesis in bacteria (by similarity) YP_001295273.1 Some similarities with RNA-binding proteins (RRM domain) COG0724 YP_001295275.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001295276.1 Essential for efficient processing of 16S rRNA. Probably part of the 30S subunit prior to or during the final step in the processing of 16S free 30S ribosomal subunits (by similarity) YP_001295277.1 Similar to predicted O-methyltransferase COG4123 YP_001295279.1 Essential for recycling GMP and indirectly, cGMP YP_001295280.1 Similar to protein of unknown function YP_001295281.1 Similar to uncharacterized stress-induced protein COG1561 YP_001295282.1 Probable drug/metabolite transporter (DMT) superfamily protein. TC 2.A.7.Y.Z YP_001295283.1 Reduction of arsenate [As(V)] to arsenite [As(III)] (by similarity) YP_001295284.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001295286.1 Some weak similarities with uncharacterized protein conserved in bacteria COG2849 YP_001295287.1 Some similarities with protein of unknown functionof the CFB phylum YP_001295288.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001295290.1 Probable transmembrane protein YP_001295291.1 ABC transporter, porine (POR), phosphate import, TC 1.B.5.1.1 YP_001295292.1 ABC transporter, binding protein (BP), MOI- family,phosphate import, TC 3.A.1.7.1 YP_001295293.1 ABC transporter, permease (IM), MOI-family, phosphate import, TC 3.A.1.7.1 YP_001295294.1 ABC transporter, permease (IM), MOI-family, phosphate import, TC 3.A.1.7.1 YP_001295295.1 ABC transporter, ATP-binding protein (ABC), MOI- family, phosphate import, TC 3.A.1.7.1 YP_001295296.1 Unknown function, probably involved in phosphate transport and/or metabolism (by similarity) YP_001295297.1 Some similarities with UDP-N-acetylglucosamine:LPSN- acetylglucosamine transferase COG0707 YP_001295298.1 Similar to uncharacterized conserved protein COG2908. Probable phosphohydrolase YP_001295299.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001295300.1 Some similarities with putative threonine efflux protein of Cytophaga hutchinsonii. Probable transmembrane protein YP_001295301.1 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairsalkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Can also repair O-4-methylthymine (by similarity) YP_001295303.1 Cytochromes c (cytC) can be defined as electron- transfer proteins having one or several haem c groups YP_001295306.1 Similar to protein of unknown function of Leptospira interrogans. Probable transmembrane protein YP_001295307.1 Probable lipoprotein. Similar to cytochrome c, mono- and diheme variants COG2010 YP_001295308.1 Similar to protein of unknown function. Probable transmembrane protein YP_001295309.1 Similar to heme/copper-type cytochrome/quinol oxidases, subunit 2 COG1622 YP_001295310.1 Similar to heme/copper-type cytochrome/quinol oxidases, subunit 1 COG0843 YP_001295311.1 Some similarities with protein of unknown functionof Flavobacterium psychrophilum YP_001295312.1 Probable transmembrane protein YP_001295313.1 Similar to protein of unknown function of the CFB phylum YP_001295316.1 Some weak similarities with DNA-directed RNA polymerase YP_001295318.1 Some similarities with predicted ATPase COG3378 YP_001295320.1 Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template (by similarity) YP_001295321.1 Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template (by similarity) YP_001295322.1 Probable transmembrane protein. Some weak similarities with proteins of unknown function YP_001295323.1 Some similarities with unknown protein of Methanosarcina acetivorans YP_001295324.1 This protein performs the mismatch recognition step during the DNA repair process YP_001295325.1 Similar to protein of unknown function of the CFB phylum YP_001295326.1 Similar to SpoU, rRNA methylases COG0566 YP_001295327.1 N-terminal region similar to 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase involved in dihydrofolate biosynthesis (first step) and C-terminal region similar to deoxynucleoside kinases COG1428 YP_001295328.1 Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane (by similarity) YP_001295329.1 Similar to outer membrane assembly protein of the CFB phylum YP_001295330.1 Similar to protein of unknown function YP_001295331.1 Similar to hypothetical protein YqiI of Bacillus subtilis. Similar to N-acetylmuramoyl-L-alanine amidase COG0860 YP_001295332.1 Similar to protein of unknown function of the CFB phylum YP_001295333.1 Lipopolysaccharide core biosynthesis YP_001295334.1 Similar to PorR protein of Porphyromonas gingivalis YP_001295335.1 Galactose metabolism; third step YP_001295337.1 Involved in fatty acid biosynthesis YP_001295340.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_001295341.1 Similar to aspartate/tyrosine/aromatic aminotransferase COG0436 YP_001295342.1 Similar to DesD protein of Synechocystis YP_001295343.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001295344.1 Proline utilization YP_001295345.1 protein associated with Co2+ and Mg2+ efflux YP_001295346.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Porphyromonas gingivalis. Probable exported protein YP_001295348.1 Removes the amino-terminal methionine from nascentproteins (by similarity) YP_001295349.1 Outer Membrane Factor (OMF) Family. TC 1.B.17.Y.Z YP_001295350.1 ABC transporter, membrane fusion protein (MFP), DLP- family, export of unknown substrat. Probable transmembrane protein. TC 8.A.1.Y.Z YP_001295351.1 ABC transporter, permease and ATP-binding protein (IM-ABC), DLP-family, export of unknown substrat, TC 3.A.1.Y.Z YP_001295354.1 Probable transmembrane protein YP_001295355.1 Similar to cation transport ATPase COG2217 YP_001295356.1 Hydroxyethylthiazole phosphate biosynthesis (by similarity) YP_001295357.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_001295358.1 Thiamine metabolism YP_001295359.1 Thiamine metabolism YP_001295360.1 Thiamine metabolism YP_001295361.1 Required for the synthesis of the thiazole moiety of thiamine (by similarity) YP_001295362.1 Required for the synthesis of the thiazole moiety of thiamine (by similarity) YP_001295363.1 Similar to dinucleotide-utilizing enzymes involvedin molybdopterin and thiamine biosynthesis family 2 COG0476 YP_001295364.1 Catalyzes the phosphorylation of UMP to UDP YP_001295365.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001295366.1 Similar to exopolyphosphatase COG0248 YP_001295367.1 Major Facilitator Superfamily (MFS). TC 2.A.1.Y.Z. YP_001295368.1 Probable exported protein similar to protein of unknown function of Flavobacterium psychrophilum YP_001295369.1 Some similarities to protein of unknown function of the CFB phylum YP_001295370.1 Monovalent Cation:Proton Antiporter-2 (CPA2) Family. TC 2.A.37.2.Z YP_001295371.1 Similar to protein of unknown function of Streptomyces and Xanthomonas YP_001295372.1 Similar to acetyltransferase COG0456 YP_001295373.1 Major Facilitator Superfamily (MFS). TC 2.A.1.Y.Z. YP_001295374.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic YP_001295376.1 Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1 and L-valine biosynthesis; L-valine from pyruvate: step 1 (By similarity) YP_001295377.1 Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1 and L-valine biosynthesis; L-valine from pyruvate: step 1 (By similarity) YP_001295378.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001295379.1 Acts on leucine, isoleucine and valine (by similarity) YP_001295381.1 Similar to FOG: PAS/PAC domain COG2202 YP_001295383.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001295384.1 forms a direct contact with the tRNA during translation YP_001295385.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001295386.1 Catalyzes the biosynthesis of deoxyribonucleotidesfrom the corresponding ribonucleotides, precursors that are necessary for DNA synthesis (By similarity) YP_001295387.1 Catalyzes the biosynthesis of deoxyribonucleotidesfrom the corresponding ribonucleotides, precursors that are necessary for DNA synthesis (By similarity) YP_001295388.1 Similar to protein of unknown function of the CFB phylum YP_001295389.1 The 6 TMS Putative MarC Transporter (MarC) Family.TC 9.B.10.Y.Z YP_001295390.1 Probable transmembrane protein YP_001295392.1 The enzyme shows specific recognition of a C- terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala- Ala-|-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala (by similarity) YP_001295393.1 Pyrimidine metabolism YP_001295394.1 Probable transmembrane protein YP_001295396.1 N-terminal region similar to universal stress protein UspA and related nucleotide-binding proteins COG0589 YP_001295397.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001295398.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001295399.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001295400.1 Function not known ; probably interacts with the ribosomes in a GTP dependent manner (by similarity) YP_001295401.1 Similar to uncharacterized conserved protein COG2996 YP_001295402.1 Menaquinone biosynthesis YP_001295403.1 Menaquinone biosynthesis YP_001295404.1 Similar to predicted aminopeptidases COG2234 YP_001295405.1 Similar to monofunctional lysine-ketoglutarate reductase of eukaryotes YP_001295406.1 Probably involved in peptidoglycan modification (by similarity) YP_001295407.1 Similar to protein of unknown function YP_001295408.1 Some similarities with uncharacterized protein HicB encoded in hypervariable junctions of pilus gene clusters COG4226 YP_001295409.1 Similar to protein of unknown function YP_001295410.1 Some similarities protein of unknown function YP_001295411.1 The TraG/TraD family are bacterial conjugation proteins. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome YP_001295413.1 Required for the horizontal transfer of genetic information (by similarity) YP_001295415.1 Similar to protein of unknown function of Bacteroides YP_001295416.1 Probable transmembrane protein YP_001295418.1 Probable transmembrane protein YP_001295419.1 Some similarities with hypothetical protein of Methanosarcina mazei. Probable transmembrane protein YP_001295421.1 Acetylation of N-terminal amino-acid of ribosomal protein YP_001295422.1 Menaquinone biosynthesis YP_001295423.1 Contains tetratrico peptide repeat (TPR), a structural motif that mediates protein\u2013protein interactions and the assembly of multiprotein complexes YP_001295424.1 Similar to protein of unknown function of Leptospira interrogans and Cytophaga hutchinsonii YP_001295425.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_001295426.1 Probable major facilitator superfamily (MFS) permease, EmrB/QacA family. Probable drug:H +Antiporter-1 (14 Spanner) (DHA2) family. TC 2.A.1.3.Z YP_001295427.1 Membrane Fusion Protein (MFP) Family. Probable transmembrane protein. TC 8.A.1.Y.Z YP_001295428.1 Outer Membrane Factor (OMF) Family. TC 1.B.17.Y.Z YP_001295429.1 Similar to transcriptional regulator COG1309 YP_001295430.1 Some weak similarities with predicted metalloprotease of Synechococcus elongatus YP_001295431.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001295432.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001295433.1 Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3 YP_001295434.1 Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4 YP_001295435.1 Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2 YP_001295436.1 Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1 and Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4- aminobenzoate from chorismate: step 1 (by similarity) YP_001295437.1 Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1 (by similarity) YP_001295438.1 Some similarities with uncharacterized conserved protein COG2353 YP_001295439.1 Similar to nitroreductase COG0778 YP_001295440.1 Similar to transcriptional regulators COG1846 YP_001295441.1 Similar to rhodanese-related sulfurtransferase COG0607 YP_001295442.1 Some similarities with 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases COG0654. Probable transmembrane protein YP_001295443.1 Function not known. Is coded in an operon essential for cell division in E. coli YP_001295444.1 Similar to TPR-domain containing protein of the CFB phylum YP_001295445.1 Similar to putative TonB-dependent receptor of the CFB phylum YP_001295446.1 Similar to outer membrane receptor proteins, mostly Fe transport COG1629. TC 1.B.14.Y.Z YP_001295448.1 Amino-acid biosynthesis; L-lysine biosynthesis viaDAP pathway; tetrahydrodipicolinate from L-aspartate: step 2 ; L-methionine biosynthesis; L-homoserine from L- aspartate: step 2 ; L-threonine biosynthesis; L-threonine from L-aspartate: step 2 (by similarity) YP_001295449.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001295450.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP YP_001295451.1 DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers ofdouble-stranded DNA rings, including catenanes and knotted rings (by similarity) YP_001295452.1 Catalyzes the reversible oxidation of malate to oxaloacetate YP_001295453.1 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001295454.1 Similar to protein secretion chaperone CsaA of Bacillus subtilis YP_001295455.1 Similar to protein of unknown function of the CFB phylum YP_001295456.1 ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family, LLP-subfamily, drug export, TC 3.A.1.Y.Z YP_001295457.1 Highly similar to psychrophilic valine dehydrogenase of Flavobacterium frigidimaris KUC-1 YP_001295458.1 One of the proteins essential for the formation ofthe RNA polymerase antitermination complex in the presence of lambda phage N protein. However, it is involved in the transcription termination process at certain sites during normal bacterial growth. Binds to the boxA RNA motif (bysimilaritty) YP_001295459.1 Similar to protein of unknown function of the CFB phylum YP_001295460.1 Part of the secDF-yidC-yajC translocase complex. TC : 3.A.5.1.1 ; TC : 9.B.18.1.1 YP_001295461.1 Pyrimidine biosynthesis; sixth (last) step YP_001295462.1 ABC transporter, binding protein (BP), ISVH-family, import of unknown substrat, TC 3.A.1.Y.Z YP_001295463.1 Similar to predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) COG0596 YP_001295464.1 Folate biosynthesis YP_001295465.1 Some similarities with biopolymer transport protein COG0811 YP_001295466.1 Some similarities with biopolymer transport protein COG0848 YP_001295467.1 Similar to membrane protein TerC, possibly involved in tellurium resistance COG0861 YP_001295468.1 Glutamate metabolism YP_001295469.1 Similar to outer membrane protein and related peptidoglycan-associated (lipo)proteins COG2885 YP_001295470.1 Probable transmembrane protein YP_001295471.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released YP_001295472.1 Probable transmembrane protein YP_001295473.1 Similar to putative outer membrane protein of Bacteroides sp. and to YfbK protein of E. coli YP_001295474.1 Similar to predicted transcriptional regulator COG2378 YP_001295479.1 ABC2 type, ART family, REG subfamily protein, probably involved in regulation of translation initiation YP_001295483.1 Contains HRDC domain YP_001295485.1 Similar to protein of unknown function. Possibly involvement in lipid metabolism YP_001295486.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001295487.1 Similar to uncharacterized conserved protein COG2326 YP_001295488.1 Some similarities with protein of unknown functionof Cytophaga hutchinsonii and Nostoc punctiforme. Putative lipoprotein YP_001295489.1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (bysimilarity) YP_001295490.1 Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily. TC 2.A.66.1.Z YP_001295491.1 Similar to membrane protease subunits, stomatin/prohibitin homologs COG0330. Probable transmembrane protein YP_001295492.1 Some weak similarities with protein of unknown function YP_001295493.1 The ArgK protein acts as an ATPase enzyme and as akinase, and phosphorylates periplasmic binding proteins involved in the LAO (lysine, arginine, ornithine)/AO transport systems (by similarities) YP_001295494.1 Confers the resistance against fosmidomycin. TC 2.A.1.35.1 YP_001295495.1 Glycolate oxidase YP_001295496.1 Some similarities with protein of unknown functionof Cytophaga hutchinsonii YP_001295498.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001295499.1 Some weak similarities with proteins of unknown function YP_001295500.1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (bysimilarity) YP_001295501.1 Some similarities with protein of unknown functionof Cytophaga hutchinsonii YP_001295502.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, there are paralogous proteins that have been found to be nonessential but do function in secretion of a subset of exported proteins YP_001295503.1 Similar to protein of unknown function of the CFB phylum YP_001295504.1 Similar to uncharacterized conserved protein COG2096 YP_001295505.1 ABC transporter, ATP-binding protein (ABC), o228- family, import of unknown substrat, TC 3.A.1.Y.Z YP_001295506.1 Similar to predicted O-methyltransferase COG4122 YP_001295508.1 Similar to protein of unknown function of Streptomyces and Xanthomonas sp. YP_001295509.1 ABC2 type, ART family, REG subfamily protein, probably involved in regulation of translation initiation YP_001295510.1 Similar to predicted glycosyltransferases COG1216 YP_001295511.1 E2 component of branched-chain alpha-keto acid dehydrogenase complex. The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched- chain alpha-ketoacid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (by similarity) YP_001295512.1 Probable exported protein similar to protein of unknown function of Flavobacterium psychrophilum YP_001295516.1 Some weak similarities with proteins of unknown function YP_001295518.1 Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridinediphosphate from GTP: step 1 (by similarity) YP_001295519.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001295520.1 Similar to protein of unknown function YP_001295521.1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (by similarity) YP_001295522.1 Similar to biotin-(acetyl-CoA carboxylase) ligase COG0340 YP_001295523.1 Similar to uncharacterized homolog of plant Iojap protein COG0799 YP_001295524.1 Seems to act as an ATP-dependent zinc metallopeptidase. Involved in the degradation of sigma-32. Degrades C-terminal-tagged cytoplasmic proteins. These proteins are tagged with an 11-amino-acid nonpolar destabilizing tail via a mechanism involving the 10SA (ssrA) stable RNA (by similarity) YP_001295525.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001295526.1 Phospholipid biosynthesis YP_001295527.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine YP_001295528.1 Similar to eukaryotic Acyl CoA binding protein COG4281 YP_001295529.1 Central region similar to superoxide dismutase COG0605 YP_001295530.1 Some weak similarities with putative periplasmic protease COG0793 YP_001295532.1 Similar to predicted permeases COG0795. Probable transmembrane protein YP_001295533.1 Similar to protein of unknown function. Probable transmembrane protein YP_001295534.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_001295535.1 Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding,DNA binding, and interaction with dnaC protein, primase, and other prepriming proteins (by similarity) YP_001295537.1 Some similarities with protein of unknown functionof Flavobacterium psychrophilum YP_001295538.1 Some weak similarities with putative YapH protein of Bdellovibrio bacteriovorus YP_001295539.1 Similar to predicted membrane protein COG3781 YP_001295540.1 Transport of potassium into the cell. TC : 2.A.72.Y.Z (By similarity) YP_001295541.1 Putative lipoprotein, similar to putative oxidoreductase of Streptomyces sp. YP_001295542.1 Probable exported protein YP_001295543.1 Probable transmembrane protein YP_001295544.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released YP_001295545.1 Similar to predicted phosphatase/phosphohexomutaseCOG0637 YP_001295548.1 Similar to protein of unknown function of the CFB phylum YP_001295551.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001295552.1 Similar to protein of unknown function YP_001295553.1 ABC transporter, ATP-binding protein (ABC), o228- family, import of unknown substrat, TC 3.A.1.Y.Z YP_001295554.1 Start doubtful, the first ATG was choosen. Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversibleoxidation-reduction of methionine sulfoxide in proteins to methionine (by similarity) YP_001295555.1 Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridinediphosphate from GTP: step 1 (by similarity) YP_001295556.1 Similar to protein of unknown function of Methanococcus maripaludis YP_001295559.1 Some similarities with protein of unknown functionof Pirellula sp. YP_001295560.1 Serine biosynthesis; first step YP_001295561.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_001295562.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001295563.1 Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Although the function of this ferredoxin is unknown it is probable that it has a role as a cellular electron transfer protein. Involved in the in vivo assembly of the Fe-S clustersin a wide variety of iron-sulfur proteins (by similarity) YP_001295564.1 Some weak similarities with protein of unknown function of Flavobacterium psychrophilum YP_001295565.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001295566.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.1.Z YP_001295567.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001295568.1 Putative nucleotidyltransferase YP_001295569.1 Putative nucleotidyltransferase YP_001295570.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001295571.1 Some weak similarities with predicted aminopeptidases COG2234 YP_001295573.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Bacteroides thetaiotaomicron YP_001295574.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001295575.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001295576.1 Similar uncharacterized proteins, LmbE homologs COG2120 YP_001295578.1 Menaquinone biosynthesis YP_001295579.1 Similar to uncharacterized protein, possibly involved in aromatic compounds catabolism COG2050 YP_001295580.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Porphyromonas gingivalis YP_001295581.1 Has a helix-destabilizing activity, which is not coupled to the ATPase activity. Can unwind the 23S rRNA as well as 16S rRNA. Exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA. Could play a major role in ribosome assembly, specifically in the assembly process of the active center of 50S ribosomal subunits (by similarity) YP_001295582.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Nudix family protein YP_001295583.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001295586.1 Similar to DEAD-box helicases. A diverse family ofproteins involved in ATP-dependent RNA unwinding YP_001295587.1 Similar to response regulator containing CheY- likereceiver, AAA-type ATPase, and DNA-binding domains COG2204 YP_001295588.1 ABC transporter, permease (IM), DRI-family, DRB- subfamily, Na(+) export, TC 3.A.1.115.1 YP_001295589.1 ABC transporter, ATP-binding protein (ABC), DRI- family, DRB-subfamily, Na(+) export, TC 3.A.1.115.1 YP_001295590.1 Interacts with dnaK to disassemble a protein complex at the phage lambda origin of replication. Stimulates, jointly with grpE, the ATPase activity of dnaK. Induction by heat shock (by similarity) YP_001295591.1 Start doubtful, the first ATG was choosen. Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress- denatured proteins, in association with dnaK and grpE. It is the nucleotide exchange factor for dnaK and may function as a thermosensor (by similarity) YP_001295592.1 Similar to nucleoside-diphosphate-sugar epimerasesCOG1090, COG0451, COG0702 YP_001295593.1 Similar to protein of unknown function of Vibrio sp. YP_001295594.1 Similar to uncharacterized protein conserved in bacteria COG3296. Probable transmembrane protein YP_001295595.1 Similar to predicted transcriptional regulators COG1695 YP_001295596.1 N-terminal region similar to protein of unknown function of the CFB phylum. Probable transmembrane protein YP_001295597.1 Similar to putative lipoproteins YP_001295598.1 Weakly similar to to protein of unknown function of Dehalococcoides sp. YP_001295599.1 Similar to uncharacterized protein conserved in bacteria COG3708 YP_001295600.1 Similar to 2-keto-4-pentenoate hydratase/2-oxohepta- 3-ene-1,7-dioic acid hydratase (catechol pathway) COG0179 YP_001295601.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001295602.1 Pentose phosphate pathway YP_001295603.1 Pentose phosphate pathway YP_001295604.1 Similar to outer membrane protein and related peptidoglycan-associated (lipo)proteins COG2885 YP_001295605.1 De novo purine biosynthesis; fifth step YP_001295606.1 Some similarities with protein of unknown functionof Pirellula sp. 1 YP_001295607.1 Similar to acetyltransferases, including N- acetylases of ribosomal proteins COG1670 YP_001295608.1 Probable exported protein YP_001295609.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Porphyromonas gingivalis YP_001295610.1 Similar to outer membrane receptor proteins, mostly Fe transport COG1629. TC 1.B.14.Y.Z YP_001295611.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001295613.1 Similar to uncharacterized low-complexity proteinsCOG1357 YP_001295614.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001295615.1 Some similarities with Endonuclease I COG2356 YP_001295616.1 rRNA (cytosine-C(5)-)-methyltransferase Sun YP_001295617.1 Probable transmembrane protein YP_001295618.1 Similar to protein of unknown function of Leptospira interrogans and Vibrio sp. YP_001295619.1 Similar to uncharacterized conserved protein COG3332 YP_001295620.1 Similar to protein of unknown function of Leptospira interrogans and Vibrio sp. YP_001295621.1 Similar to peroxiredoxin COG1225. Peroxiredoxins are a ubiquitous family of antioxidant proteins YP_001295622.1 Similar to cAMP-binding proteins - catabolite geneactivator and regulatory subunit of cAMP-dependent protein kinases COG0664 YP_001295623.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001295625.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide. Component of two multienzyme complexes: pyruvate dehydrogenase complex and oxoglutarate dehydrogenase complex. YP_001295626.1 Similar to uncharacterized conserved protein COG2268 YP_001295627.1 Belongs to the class-V pyridoxal-phosphate- dependent aminotransferase family. Biosynthesis of Fe-S cluster YP_001295628.1 Similar to predicted phosphoesterase COG0622 YP_001295632.1 Similar to uncharacterized conserved protein COG4748 YP_001295634.1 Two-component system response regulatory protein containing receiver domain and LuxR-type DNA-binding domain YP_001295635.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Bacteroides thetaiotaomicron. Probable transmembrane protein YP_001295636.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001295637.1 Similar to uncharacterized protein conserved in bacteria COG3022 YP_001295638.1 N-terminal region similar to alpha subunit COG1071and C-terminal region similar to beta subunit COG0022 of pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type YP_001295639.1 Some weak similarities with putative aminopeptidases YP_001295640.1 Central region similar to ribonuclease YP_001295641.1 Similar to membrane protein TerC, possibly involved in tellurium resistance COG0861 YP_001295642.1 Putative lipoprotein YP_001295643.1 Probable transmembrane protein YP_001295644.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_001295645.1 Similar to protein of unknown function YjqA of Bacillus subtilis YP_001295646.1 Similar to predicted divalent heavy-metal cations transporter of Cytophaga hutchinsonii YP_001295647.1 Similar to putative methyltransferases YP_001295648.1 Similar to predicted N6-adenine-specific DNA methylase COG0116 YP_001295649.1 Probable transmembrane protein YP_001295651.1 Some similarities with protein of unknown functionof Bacteroides sp. Probable exported protein YP_001295652.1 Putative lipoprotein YP_001295653.1 Similar to SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase COG2265 YP_001295654.1 Some similarities with putative transcription regulators YP_001295655.1 Similar to site-specific DNA methylase COG0270. Probable DNA (cytosine-5-)-methyltransferase YP_001295657.1 Similar to uncharacterized protein conserved in bacteria COG3797 YP_001295658.1 Controls arginine catabolism (by similarity) YP_001295659.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Probable transmembrane protein YP_001295660.1 Probable transmembrane protein YP_001295661.1 Production of the modified nucleoside 2-methylthio- cis-ribozeatin (MS[2]IO[6]A) found in some tRNAs. Catalyzes the oxygen-dependent transformation of MS[2]I[6]A into MS[2]IO[6]A (by similarity) YP_001295662.1 Similar to glycosyltransferase COG0438 YP_001295663.1 Similar to predicted metalloprotease COG2321 YP_001295664.1 Similar to predicted membrane protein COG2323 YP_001295665.1 Responsible for the addition of glutamate residuesto the C-terminus of ribosomal protein S6 (by similarity) YP_001295666.1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with dnaK, dnaJ and grpE. Acts before dnaK, in the processing of protein aggregates (by similarity) YP_001295667.1 DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers ofdouble-stranded DNA rings, including catenanes and knotted rings (by similarity) YP_001295668.1 Contains tetratrico peptide repeat (TPR), a structural motif that mediates protein\u2013protein interactions and the assembly of multiprotein complexes YP_001295669.1 Putative endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis YP_001295670.1 Similar to protein of unknown function of the CFB phylum. Some similarities with organic solvent tolerance protein OstA COG1452. Probable transmembrane protein YP_001295671.1 Some similarities with N-acetylmuramoyl-L- alanineamidase COG0860. Hydrolyzes the link between N- acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. Probable exported protein YP_001295672.1 Similar to protein of unknown function of the CFB phylum. Weakly similar to ABC-type transport system involved in resistance to organic solvents, periplasmic component COG1463. Probable exported protein YP_001295673.1 Similar to N-terminal region of Fe-S oxidoreductase COG0247 YP_001295675.1 Similar to C-terminal region of Fe-S oxidoreductase COG0247 YP_001295676.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001295677.1 N-terminal region similar to beta-glucosidase- related glycosidases COG1472 and C-terminal region similar to beta-lactamase class C and other penicillin binding proteins COG1680 YP_001295678.1 Similar to uncharacterized membrane protein COG1814 YP_001295679.1 Probable exported protein. Some similarities with protein of unknown function of Trichodesmium erythraeum IMS101 YP_001295680.1 Similar to predicted acyltransferases COG1835. Probable transmembrane protein YP_001295681.1 Similar to glycosyltransferase COG0438 YP_001295682.1 Similar to transcriptional regulator COG0583 YP_001295683.1 Similar to putative intracellular protease/amidaseCOG0693 YP_001295684.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001295685.1 Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family protein. TC 2.A.23.1.Z YP_001295687.1 Similar to uncharacterized protein conserved in bacteria COG3011 YP_001295688.1 Similar to cell wall-associated hydrolases (invasion-associated proteins) COG0791 YP_001295689.1 Similar to acetyl-CoA acetyltransferase COG0183 YP_001295701.1 Similar to protein of unknown function of Bacteroides fragilis YP_001295702.1 Similar to protein of unknown function of Bacteroides fragilis YP_001295703.1 Similar to protein of unknown function of Bacteroides fragilis YP_001295708.1 Some similarities with protein of unknown functionof Alcaligenes faecalis YP_001295709.1 Similar to protein of unknown function of Bacteroides fragilis YP_001295710.1 Similar to protein of unknown function of Bacteroides fragilis YP_001295713.1 Similar to protein of unknown function of Bacteroides fragilis YP_001295715.1 Prokaryotic DNA binding proteins belonging to the xenobiotic response element XRE family of transcriptional regulators YP_001295716.1 Similar to IbrA protein of E. coli and to predicted phosphoadenosine phosphosulfate sulfotransferase COG3969 YP_001295717.1 Similar to IbrB protein of E. coli. Probable DNA- binding protein YP_001295718.1 Similar to protein of unknown function of Listeriasp. YP_001295722.1 Similar to protein of unknown function of Bacteroides fragilis YP_001295723.1 Similar to protein of unknown function of Bacteroides fragilis YP_001295724.1 Similar to periplasmic serine proteases COG0616 YP_001295725.1 Probable transmembrane protein YP_001295726.1 Cell-wall hydrolase probably involved in cell- wallhydrolysis, septation or recycling (by similarity) YP_001295727.1 Probable exported protein YP_001295730.1 Probable transmembrane protein YP_001295738.1 Some weak similarities with protein of unknown function of Erwinia carotovora YP_001295745.1 Some similarities with DNA primase DnaG COG0358 YP_001295750.1 ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family, MDL-subfamily, drug export, TC 3.A.1.Y.Z YP_001295751.1 Similar to uncharacterized conserved protein COG0217 YP_001295752.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001295753.1 Similar to predicted sugar kinase COG0063 YP_001295754.1 Histidine degradation; first step YP_001295755.1 Similar to spermidine synthase COG0421 YP_001295756.1 Similar to 1-acyl-sn-glycerol-3-phosphate acyltransferase COG0204 YP_001295757.1 Similar to putative transcriptional regulators of the CFB phylum YP_001295758.1 Similar to predicted carboxypeptidase COG2866 YP_001295759.1 Similar to transcriptional regulators COG1522 YP_001295760.1 Similar to protein of unknown function of Bacillussp. YP_001295761.1 Similar to predicted Rossmann fold nucleotide- binding protein COG1611 YP_001295762.1 Probable pseudogene, similar to C-terminal region of excinuclease ABC, A subunit UvrA YP_001295763.1 Similar to protein of unknown function of Vibrio parahaemolyticus YP_001295764.1 Similar to protein of unknown function of Vibrio parahaemolyticus YP_001295765.1 The UvrABC repair system catalyzes the recognitionand processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate (By similarity) YP_001295767.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001295769.1 Similar to uncharacterized conserved protein COG3124 YP_001295770.1 Similar to phosphomannomutase COG1109 YP_001295771.1 C-terminal region similar to cheY-homologous receiver domain YP_001295772.1 Similar to signal transduction histidine kinase COG0642 YP_001295773.1 Some similarities with putative transcription regulators YP_001295774.1 Similar to site-specific DNA methylase COG0270. Probable DNA (cytosine-5-)-methyltransferase YP_001295776.1 Probable pyridoxal 5'-phosphate (PLP)-dependent enzyme, similar to selenocysteine lyase COG0520 and cysteinesulfinate desulfinase/cysteine desulfurase and related enzymes COG1104 YP_001295777.1 Similar to lauroyl/myristoyl acyltransferase COG1560. Probable exported protein YP_001295778.1 Similar to uncharacterized membrane protein COG0705 YP_001295779.1 Similar to uncharacterized conserved protein COG2968 YP_001295780.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001295781.1 Probable pyridoxal 5'-phosphate (PLP)-dependent enzyme, N-terminal region similar to putative homoserine kinase type II (protein kinase fold) COG2334 and C- terminal region similar to 4-aminobutyrate aminotransferase and related aminotransferases COG0160 YP_001295782.1 Some similarities with protein of unknown functionof Nocardia farcinica YP_001295783.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001295784.1 Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post- incision events of nucleotide excision repair and methyl- directed mismatch repair YP_001295785.1 Similar to putative translation factor (SUA5) COG0009 YP_001295786.1 Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues (by similarity) YP_001295787.1 Similar to cysteine synthase COG0031 YP_001295788.1 Some similarities with endonucleases YP_001295789.1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (by similarity) YP_001295790.1 Glycine, serine and threonine metabolism YP_001295791.1 Similar to uncharacterized protein conserved in bacteria COG0718 YP_001295792.1 Single-stranded-DNA-specific exonuclease. Requiredfor many types of recombinational events, although the stringency of the requirement for recJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available YP_001295793.1 Probable transmembrane protein YP_001295794.1 Some similarities with putative DNA mismatch repair proteins YP_001295796.1 Resistance-Nodulation-Cell Division (RND) Superfamily. Probable transmembrane protein. TC 2.A.6.2.Z YP_001295797.1 Membrane Fusion Protein (MFP) Family. Probable lipoprotein. TC 8.A.1.Y.Z YP_001295798.1 Similar to protein tyrosine/serine phosphatase COG2365 YP_001295799.1 Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones(by similarity) YP_001295800.1 Gluconeogenesis from serine (by similarity) YP_001295801.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001295802.1 Some similarities with putative periplasmic protease COG0793 YP_001295804.1 Ethanol utilization; second step YP_001295805.1 Probable transmembrane protein YP_001295806.1 Mechanosensitive (MS) channels provide protection against hypo-osmotic shock, responding both to stretching of the cell membrane and to membrane depolarisation. YP_001295807.1 Similar to putative zinc protease of Cytophaga hutchinsonii and Bacteroides thetaiotaomicron YP_001295808.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001295810.1 IF-3 binds to the 30S ribosomal subunit and shiftsthe equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesisinitiation begins. IF-3 is also a translational repressorprotein, it controls the translation of its own gene by binding to its mRNA (by similarity) YP_001295811.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_001295813.1 Some similarities with putative Zn-dependent proteases COG4783, COG4784 and COG0501 YP_001295814.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001295816.1 Similar to protein of unknown function of Mycobacterium leprae YP_001295817.1 Some similarities with uncharacterized protein conserved in bacteria COG4807 YP_001295819.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001295820.1 Probable lipoprotein YP_001295821.1 Similar to predicted protease with the C-terminal PDZ COG3975 YP_001295822.1 Similar to protein of unknown function of Nocardiafarcinica and Streptomyces coelicolor YP_001295823.1 Probable transmembrane protein YP_001295824.1 Similar to uncharacterized protein conserved in bacteria COG3877 YP_001295825.1 Similar to peroxiredoxin COG0450. Peroxiredoxins are a ubiquitous family of antioxidant proteins YP_001295826.1 Start doubtful, the first XTG was choosen. Some similarities with protein of unknown function of Flavobacterium psychrophilum YP_001295828.1 Some similarities with cytochrome c of Thermus thermophilus. Probable transmembrane protein YP_001295829.1 Probable transmembrane protein YP_001295830.1 N-terminal region similar to cytochrome c oxidase,cbb3-type, subunit II, CcoO and C-terminal region similarto cytochrome c CccA. Probable transmembrane protein YP_001295831.1 C-terminal region similar to cytochrome c oxidase,cbb3-type, subunit I, CcoN. Probable transmembrane protein YP_001295832.1 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, lolA. YP_001295833.1 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, lolA YP_001295834.1 Membrane Fusion Protein (MFP) Family. Probable lipoprotein. TC 8.A.1.Y.Z YP_001295835.1 Similar to transcriptional regulator COG1309 YP_001295836.1 Similar to cAMP-binding proteins - catabolite geneactivator and regulatory subunit of cAMP-dependent protein kinases COG0664 YP_001295837.1 Similar to uncharacterized conserved protein COG3012 YP_001295838.1 Start doubtful YP_001295839.1 Membrane Fusion Protein (MFP) Family. Probable lipoprotein. TC 8.A.1.Y.Z YP_001295840.1 Resistance-Nodulation-Cell Division (RND) Superfamily. Probable transmembrane protein. TC 2.A.6.2.Z YP_001295841.1 Outer Membrane Factor (OMF) Family protein. TC 1.B.17.Y.Z YP_001295842.1 Similar to universal stress protein UspA and related nucleotide-binding proteins COG0589 YP_001295843.1 N-terminal region similar to CheY-like receiver domain and C-terminal region similar to putative dolichyl- phosphate beta-glucosyltransferase YP_001295844.1 Some weak similarities with predicted integral membrane protein COG5617 YP_001295845.1 Probable exported protein YP_001295846.1 Some similarities with to endo-beta-mannanase COG3934. Putative lipoprotein YP_001295847.1 Similar to glycosyltransferase COG0438 YP_001295848.1 Probable transmembrane protein YP_001295850.1 Enables the cell to use acetate during aerobic growth YP_001295851.1 Similar to DNA polymerase III, epsilon subunit andrelated 3'-5' exonucleases COG0847 YP_001295852.1 Predicted signal-transduction protein containing cAMP-binding and CBS domains COG2905 YP_001295853.1 Similar to superfamily II DNA and RNA helicases COG0513 YP_001295854.1 Similar to DNA or RNA helicases of superfamily II COG1061 YP_001295856.1 Similar to YdzA protein of Bacilus subtilis YP_001295857.1 Similar to small-conductance mechanosensitive (MS)channel COG0668. MS channels provide protection against hypo-osmotic shock, responding both to stretching of the cell membrane and to membrane depolarisation. YP_001295858.1 Similar to acyl-CoA hydrolase COG1607 YP_001295859.1 Similar to ADP-ribose pyrophosphatase COG1051 YP_001295861.1 histidine biosynthesis bifunctional protein HisIE; catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_001295862.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001295863.1 Amino-acid biosynthesis; L-histidine biosynthesis;L- histidine from PRPP: step 4 YP_001295864.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001295865.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate YP_001295866.1 Amino-acid biosynthesis; L-histidine biosynthesis;L- histidine from PRPP: step 7 YP_001295867.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001295868.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_001295869.1 Probable transmembrane protein YP_001295870.1 Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones(by similarity) YP_001295871.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Probable transmembrane protein YP_001295872.1 Fatty acid biosynthesis pathway; first reduction step (by similarity) YP_001295873.1 DNA polymerase III is a complex, multichain enzymeresponsible for most of the replicative synthesis in bacteria (by similarity) YP_001295876.1 Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate (by similarity) YP_001295877.1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (by similarity) YP_001295879.1 Tricarboxylic acid cycle, Tetramer of two alpha and two beta subunits (by similarity) YP_001295881.1 Similar to UDP-3-O-(R-3-hydroxymyristoyl)- glucosamine N-acyltransferase LpxD YP_001295882.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001295883.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_001295884.1 catalyzes the zinc dependent deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis and catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP in fatty acid biosynthesis YP_001295885.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_001295886.1 Similar to HD superfamily phosphohydrolases COG1078 YP_001295887.1 Some weak similarities with voltage-gated potassium channel of eukaryotes. Probable transmembrane protein YP_001295888.1 Lipopolysaccharide biosynthesis; KDO biosynthesis;fourth step (by similarity) YP_001295889.1 Some similarities with ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member COG0507 YP_001295890.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001295891.1 Probable transmembrane protein containing an helix- turn-helix, AraC type motif in C-terminal YP_001295892.1 Similar to protein of unknown function of the CFB phylum YP_001295893.1 Similar to N6-adenine-specific methylase COG0742 YP_001295895.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001295897.1 Probable transmembrane protein containing an histidine kinase domain in C-terminal YP_001295899.1 Similar to transcriptional regulator COG1309 YP_001295900.1 Similar to predicted membrane protein of Cytophagahutchinsonii YP_001295902.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA YP_001295903.1 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever YP_001295905.1 Inorganic Phosphate Transporter (PiT) Family. TC 2.A.20.Y.Z YP_001295906.1 Similar to phosphate transport regulator (distant homolog of PhoU) COG1392 YP_001295907.1 Similar to acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) COG4799 YP_001295908.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Some similarities with periplasmic protease COG0793 YP_001295909.1 Some similarities with aminopeptidase N COG0308 YP_001295910.1 C-terminal region similar to AraC-type DNA- bindingdomain-containing proteins COG2207 YP_001295911.1 Similar to protein of unknown function YbcL of E. coli. Periplasmic protein YP_001295912.1 Similar to protein of unknown function of Nostoc punctiforme and Gloeobacter violaceus YP_001295913.1 Some similarities with aminopeptidase N COG0308 YP_001295914.1 Similar to predicted ATPases of PP-loop superfamily COG2102 YP_001295915.1 catalyzes branch migration in Holliday junction intermediates YP_001295916.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Contains tetratrico peptide repeat (TPR), a structural motif that mediates protein\u2013protein interactions and the assembly of multiprotein complexes YP_001295917.1 Similar to uncharacterized conserved protein COG4276 YP_001295918.1 Similar to short-chain dehydrogenases YP_001295919.1 This enzyme catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand, upon exposure to ultraviolet radiation YP_001295921.1 Similar to protein of unknown function of Anabaenasp. and Nostoc sp and similar to N-terminal region of eukaryotic soluble guanylyl cyclase beta 1 subunit YP_001295923.1 Similar to uncharacterized conserved protein COG3287 YP_001295925.1 Histidine-phosphotransfer intermediate YP_001295926.1 Similar to response regulator of the LytR/AlgR family COG3279 YP_001295927.1 Some similarities to protein of unknown function. Contains tetratrico peptide repeat (TPR), a structural motif that mediates protein\u2013protein interactions and the assembly of multiprotein complexes YP_001295928.1 Some similarities with cell surface proteins of Methanosarcina sp. YP_001295929.1 Some similarities with metalloproteases. Probable exported protein YP_001295930.1 Similar to glutamate synthase domain 2 COG0069 YP_001295931.1 Similar to 2-keto-4-pentenoate hydratase/2-oxohepta- 3-ene-1,7-dioic acid hydratase (catechol pathway) COG0179 YP_001295932.1 Similar to putative protease YdcP precursor of Escherichia coli YP_001295933.1 E1 component of branched-chain alpha-keto acid dehydrogenase complex. The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched- chain alpha-ketoacid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) YP_001295934.1 Similar to isopenicillin N synthase and related dioxygenases COG3491 YP_001295935.1 Similar to protein of unknown function YP_001295936.1 Similar to protein YciH of Escherichia coli YP_001295937.1 Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis YP_001295938.1 Acetylation of N-terminal amino-acid of ribosomal protein YP_001295940.1 Similar to putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes COG3320 YP_001295941.1 Similar to ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components COG0715 YP_001295942.1 Similar to protein of unknown function of Methanosarcina sp. Probable transmembrane protein YP_001295943.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNApolymerase or due to deamination of cytosine (By similarity) YP_001295944.1 This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatchrecognition step (by similarity) YP_001295946.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001295947.1 ABC2 type, ART family, REG subfamily protein, probably involved in regulation of translation initiation. Similar to Uup protein COG0488 YP_001295948.1 Similar to protein of unknown function. Probable transmembrane protein YP_001295949.1 Similar to predicted Fe-S oxidoreductases COG1964 YP_001295952.1 Some similarities with protein of unknown functionof Flavobacterium psychrophilum YP_001295953.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_001295954.1 Similar to short-chain dehydrogenases YP_001295955.1 Some similarities with chloromuconate cycloisomerase YkfB1 of Rhodopirellula baltica YP_001295956.1 C-terminal region similar to glutamine cyclotransferase COG3823 YP_001295957.1 Probable transmembrane protein YP_001295958.1 Similar to HolA DNA polymerase III, delta subunit COG1466 YP_001295959.1 Similar to protein of unknown function of the CFB phylum YP_001295960.1 Similar to predicted glycosyltransferases COG1216 YP_001295965.1 Similar to type III effector HopPmaJ of the plant pathogen Pseudomonas syringae YP_001295966.1 Similar to predicted methyltransferase COG0313 YP_001295968.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_001295969.1 Involved in cell wall formation (peptidoglycan biosynthesis) YP_001295970.1 Mechanosensitive (MS) channels provide protection against hypo-osmotic shock, responding both to stretching of the cell membrane and to membrane depolarisation. YP_001295971.1 Similar to response regulator of Cytophaga hutchinsonii and Porphyromonas gingivalis YP_001295972.1 Similar to predicted ATPase or kinase COG0802 YP_001295973.1 May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer YP_001295974.1 Putative lipoprotein YP_001295975.1 Similar to proteins of unknown function of Flavobacterium psychrophilum YP_001295976.1 Similar to protein of unknown function of the CFB phylum YP_001295977.1 Similar to cellulase M and related proteins COG1363 YP_001295978.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001295979.1 Similar to short-chain dehydrogenases YP_001295980.1 PhoH is a cytoplasmic protein and predicted ATPasethat is induced by phosphate starvation (by similarity) YP_001295981.1 Similar to uncharacterized conserved protein COG1912 and to Fjo14 protein of Flavobacterium johnsoniae YP_001295983.1 Similar to protein of unknown function of Streptomyces avermitilis and Kineococcus radiotolerans YP_001295984.1 Some similarities with predicted sugar kinase COG0061 YP_001295986.1 Similar to uncharacterized conserved protein COG1359 and uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides COG2329 YP_001295987.1 Similar to probable methyltransferase of Bacillus sp. YP_001295988.1 Highly similar to gliding motility protein GldF ofFlavobacterium johnsoniae. ABC transporter, permease (IM), DRI-family, DRB-subfamily, export of unknown substrat, TC 3.A.1.Y.Z YP_001295989.1 Highly similar to gliding motility protein GldG ofFlavobacterium johnsoniae, a probable membrane-anchored accesory protein of ABC transport system YP_001295990.1 DNA polymerase III is a complex, multichain enzymeresponsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, It slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity) YP_001295991.1 Similar to putative ATP-dependent RNA helicase RhlE of E. coli YP_001295992.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Probable transmembrane protein YP_001295993.1 Pyrimidine metabolism YP_001295994.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Probable transmembrane protein YP_001295995.1 Similar to predicted esterase COG0400 YP_001295996.1 Probable exported protein YP_001295997.1 Similar to metal-dependent hydrolase of the beta- lactamase superfamily I COG1235 YP_001295998.1 Similar to protein of unknown function YP_001295999.1 Similar to peroxiredoxin COG1225. Peroxiredoxins are a ubiquitous family of antioxidant proteins YP_001296000.1 Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions (bys imilarity) YP_001296001.1 Similar to protein of unknown function of Streptomyces avermitilis YP_001296002.1 Major Facilitator Superfamily (MFS). TC 2.A.1.Y.Z. YP_001296003.1 Similar to FOG: PAS/PAC domain COG2202 YP_001296004.1 Similar to FOG: PAS/PAC domain COG2202 YP_001296005.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released YP_001296006.1 The UvrABC repair system catalyzes the recognitionand processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate (By similarity) YP_001296008.1 Similar asparaginase COG1446 YP_001296009.1 Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides (by similarity) YP_001296010.1 catalyze the formation of cyanophycin which may act to store excess nitrogen YP_001296011.1 Similar to dipeptidyl peptidase IV of Flavobacterium meningosepticum. Belongs to peptidase family S15 YP_001296012.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Probable exported protein YP_001296013.1 Some similarities with predicted membrane protein COG5373 YP_001296014.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Probable transmembrane protein YP_001296017.1 Pyrimidine salvage pathway YP_001296018.1 Probable exported protein YP_001296019.1 Propionic acid fermentation. Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates (By similarity) YP_001296020.1 Probable transmembrane protein YP_001296021.1 MDM; functions in conversion of succinate to propionate YP_001296023.1 Similar to protein of unknown function of the CFB phylum YP_001296024.1 Similar to protein of unknown function YP_001296025.1 Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (by similarity) YP_001296026.1 Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; second step (by similarity) YP_001296027.1 Similar to protein of unknown function of the CFB phylum. Probable transmembrane protein YP_001296028.1 Control of plasmid partitioning; required to recognize the cis-acting partition sites (by similarity) YP_001296029.1 This protein is essential for plasmid partition. It ensures the proper distribution of newly replicated plasmids to daughter cells during cell division. ParA is trans-acting (by similarity) YP_001296030.1 Similar to hypothetical oxidoreductase YkuF of Bacillus subtilis and to mitochondrial 4-dienoyl-CoA reductase YP_001296031.1 Similar to 2-methylthioadenine synthetase COG0621 YP_001296033.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001296034.1 Probable transmembrane protein YP_001296035.1 Similar to glycosyltransferases involved in cell wall biogenesis COG0463 YP_001296036.1 Similar to phosphomannomutase COG1109 and phosphoglucomutase COG0033 YP_001296037.1 ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family, LIP-subfamily, lipid A export, TC 3.A.1.106.1 YP_001296038.1 Similar to protein of unknown function of Shewanella oneidensis YP_001296039.1 Some similarities with protein of unknown function YP_001296040.1 Similar to outer membrane receptor proteins, mostly Fe transport COG1629. TC 1.B.14.Y.Z YP_001296041.1 Similar to putative peptidase of Bacteroides YP_001296042.1 Similar to protein of unknown function of the CFB phylum YP_001296043.1 Similar to protein of unknown function of the CFB phylum YP_001296044.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP YP_001296045.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl- directed DNA mismatch repair (by similarity) YP_001296046.1 Similar to uncharacterized membrane protein (homolog of Drosophila rhomboid) COG0705 YP_001296047.1 Similar to rhomboid family protein of the CFB phylum. Probable transmembrane protein YP_001296048.1 Probable transmembrane protein YP_001296050.1 Similar to cAMP-binding proteins - catabolite geneactivator and regulatory subunit of cAMP-dependent protein kinases COG0664. Probably controls the cytochrome cbb3-type terminal oxydase (the cco operon) YP_001296051.1 May play a role in the uptake and metabolism of copper required for the assembly of the dinuclear center of cytochrome cbb3 oxidase (by similarity) YP_001296052.1 May play a role in the assembly of a functional cbb3 oxidase YP_001296053.1 Similar to eukaryotic acyl-[acyl-carrier-protein] desaturase YP_001296054.1 CcoN/CcoO FixN/FixO YP_001296055.1 Respiratory chain; terminal step. Probable transmembrane protein YP_001296056.1 C-terminal region similar to cytochrome c oxidase diheme subunit. Probable transmembrane protein YP_001296057.1 May play a role in the uptake and metabolism of copper required for the assembly of the dinuclear center of cytochrome cbb3 oxidase (by similarity) YP_001296058.1 CcoH is required for normal steady-state amount s of the enzyme. YP_001296059.1 Similar to uncharacterized conserved protein COG2836. Probable transmembrane protein YP_001296060.1 Similar to uncharacterized protein conserved in bacteria COG2841 YP_001296061.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001296062.1 Catalyzes the conversion of citrate to isocitrate YP_001296063.1 Similar to benzil reductase YueD of Baccilus sp. YP_001296064.1 Similar to MoxR-like ATPases COG0714 YP_001296065.1 Assist in the folding of extracytoplasmic proteins(by similarity) YP_001296066.1 May assist in the folding of extracytoplasmic proteins YP_001296067.1 Similar to immunogenic 75 kDa protein PG4 of Porphyromonas gingivalis YP_001296068.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Porphyromonas gingivalis YP_001296070.1 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (by similarity) YP_001296072.1 Similar to protein of unknown function of the CFB phylum YP_001296073.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001296074.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001296075.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001296076.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001296077.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001296078.1 binds directly to 23S ribosomal RNA YP_001296079.1 Influences transcription termination and antitermination. Acts as a component of the transcription complex, and interacts with the termination factor rho and RNA polymerase (by similarity) YP_001296080.1 Essential for protein export. Part of the prokaryotic protein translocation apparatus which comprise secA, secB, secD, secE, secF, secG and secY (by similarity) YP_001296081.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001296082.1 Similar to ribosome-associated protein Y (PSrp-1) COG1544 YP_001296083.1 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convertdimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) YP_001296084.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001296085.1 Similar to Acyl-CoA dehydrogenase COG1960 YP_001296086.1 Some similarities with ComEA, DNA uptake protein and related DNA-binding proteins COG1555 YP_001296088.1 Similar to protein of unknown function of the CFB phylum YP_001296089.1 DNA polymerase III is a complex, multichain enzymeresponsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function andis a proofreading 3'-5' exonuclease (by similarity) YP_001296090.1 Similar to cysteine synthase COG0031 YP_001296091.1 Similar to protein of unknown function of the CFB phylum YP_001296092.1 Similar to proteins of unknown function of Bacteroides thetaiotaomicron. Probable lipoprotein YP_001296093.1 Similar to outer membrane protein Omp121. TC 1.B.14.6.2 YP_001296094.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001296095.1 Catalyzes the transfer of the endogenously synthesized lipoate to apoproteins, creating an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoate-dependent enzymes (By similarity) YP_001296096.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001296098.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_001296099.1 Central region similar to muramidase (flagellum- specific) COG1705 and C-terminal region similar to LysM repeat COG1388 YP_001296100.1 Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1- carboxylate (ACC) to ammonia and alpha-ketobutyrate. Allows growth on ACC as a nitrogen source (by similarity) YP_001296101.1 Similar to predicted thioesterase COG0824 YP_001296102.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001296104.1 Similar to predicted methyltransferase COG0313 YP_001296105.1 Some similarities with LysM domain proteins YP_001296106.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296107.1 Similar to predicted periplasmic solute-binding protein COG1559 YP_001296108.1 Acetylation of N-terminal amino-acid of ribosomal protein YP_001296109.1 Amino-acid biosynthesis; L-lysine biosynthesis viaDAP pathway; DL-diaminopimelate from LL- diaminopimelate: single step (by similarity) YP_001296110.1 Similar to protease DegQ precursor of E. coli YP_001296111.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent YP_001296112.1 N-terminal region weakly similar to LysM repeat COG1388 and C-terminal region similar to cell wall- associated hydrolases (invasion-associated proteins) COG0791 YP_001296113.1 Similar to protein of unknown function YqfO of Bacillus subtilis YP_001296114.1 Similar to Zn-ribbon protein, possibly nucleic acid- binding COG1579 YP_001296115.1 Some similarities with predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) COG0596 YP_001296116.1 Similar to 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases COG1187 YP_001296117.1 Voltage-gated Ion Channel (VIC) Superfamily protein. TC 1.A.1.Y.Z YP_001296118.1 Similar to protein of unknown function of Francisella tularensis and Desulfotalea psychrophila. Probable transmembrane protein YP_001296119.1 Probable exported protein YP_001296120.1 Similar to uncharacterized protein conserved in bacteria COG4680 YP_001296121.1 Similar to predicted transcription regulator containing HTH domain COG5499 YP_001296122.1 Mechanosensitive (MS) channels provide protection against hypo-osmotic shock, responding both to stretching of the cell membrane and to membrane depolarisation. YP_001296123.1 Similar to uncharacterized FAD-dependent dehydrogenases COG2509 YP_001296124.1 Similar to cytotoxic translational repressor of toxin-antitoxin stability system of Crocosphaera watsonii YP_001296127.1 Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase (by similarity) YP_001296128.1 Lipopolysaccharide biosynthesis; KDO biosynthesis;first step (by similarity) YP_001296129.1 Required for correct localization of precursor proteins bearing signal peptides with the twin arginine conserved motif S/T-R-R-X-F-L-K. This sec-independent pathway is termed TAT for twin-arginine translocation system. This system mainly transports proteins with bound cofactors that require folding prior to export (by similarity) YP_001296130.1 Similar to uncharacterized homolog of gamma- carboxymuconolactone decarboxylase subunit COG0599 YP_001296131.1 ABC transporter, ATP-binding protein (ABC), YHBG family, import of unknown substrat, TC 3.A.1.Y.Z YP_001296132.1 Similar to protein of unknown function YegX of Escherichia coli, Lyzozyme M1 (1,4-beta-N- acetylmuramidase) COG3757 YP_001296133.1 Phosphatidylserine synthase YP_001296134.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296135.1 Similar to protein of unknown function. Probable transmembrane protein YP_001296136.1 Similar to protein of unknown function. Probable transmembrane protein YP_001296137.1 Similar to putative peptidase (YtmA protein) of Bacillus subtilis YP_001296138.1 Some similarities with sugar transferases involvedin lipopolysaccharide synthesis COG2148 YP_001296139.1 Probable transmembrane protein. Putative transporter YP_001296140.1 Similar to glycosyltransferase COG0438 YP_001296141.1 Similar to glycosyltransferase COG0438 YP_001296142.1 Similar to serine acetyltransferase COG1045 YP_001296144.1 Similar to predicted glycosyltransferases COG1216 YP_001296146.1 Similar to glycosyltransferase COG0438 YP_001296147.1 Weakly similar to serine acetyltransferase COG1045 YP_001296149.1 Probably involved in capsular polysaccharide biosynthesis. Catalyzes the conversion of UDP-N- acetylglucosamine into UDP-N-acetylmannosamine YP_001296150.1 Probably involved in capsular polysaccharide biosynthesis. NeuB is the prokaryotic N-acetylneuraminic acid (Neu5Ac) synthase. It catalyses the direct formation of Neu5Ac (the most common sialic acid) by condensation of phosphoenolpyruvate (PEP) and N- acetylmannosamine (ManNAc) YP_001296151.1 Probably involved in capsular polysaccharide biosynthesis YP_001296152.1 Similar to glycosyltransferases COG0463 COG1216 YP_001296155.1 Similar to glycosyltransferases COG0463 COG1215 COG1216 YP_001296156.1 Similar to glycosyltransferase COG0438 YP_001296157.1 Similar to uncharacterized protein conserved in bacteria COG3274. Probable transmembrane protein YP_001296158.1 Similar to glycosyltransferases involved in cell wall biogenesis COG0463 YP_001296159.1 Similar to glycosyltransferase COG0438 YP_001296160.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis YP_001296161.1 Probable acetyltransferase involved in lipopolysaccharide O-antigen biosynthesis YP_001296162.1 Similar to protein of unknown function YP_001296163.1 ABC transporter, ATP-binding protein (ABC), CLS- family, polysaccharide/polyol phosphate export, TC 3.A.1.Y.Z YP_001296164.1 ABC transporter, permease (IM), CLS-family, polysaccharide/polyol phosphate export, TC 3.A.1.Y.Z YP_001296166.1 Start doubtful, the first ATG was choosen. Putative exported protein YP_001296168.1 Similar to capsular polysaccharide biosynthesis protein COG4464 YP_001296169.1 Probable transmembrane protein similar to tyrosine- protein kinase Wzc of Escherichia coli YP_001296170.1 Some similarities with periplasmic protein involved in polysaccharide export COG1596. Probable transmembraneprotein YP_001296171.1 Lipopolysaccharide O-antigen biosynthesis; UDP-D- Qui2NAc biosynthesis; 1 and 2nd steps YP_001296172.1 Similar to predicted pyridoxal phosphate- dependentenzyme apparently involved in regulation of cell wall biogenesis COG0399 YP_001296173.1 Some similarities with putative acetyltransferases YP_001296174.1 Weakly similar to predicted phosphoesterase COG0622 YP_001296175.1 Similar to nucleoside-diphosphate-sugar epimerasesCOG0451 YP_001296176.1 undetermined role; similar to CarB protein but much smaller YP_001296177.1 Lipopolysaccharide O-antigen biosynthesis; sugar phosphate transferase YP_001296178.1 Similar to putative L-fucosamine transferase WbuB of Escherichia coli YP_001296179.1 Lipopolysaccharide O-antigen biosynthesis; UDP-L- FucpNAc biosynthesis; 5th step YP_001296180.1 Lipopolysaccharide O-antigen biosynthesis; UDP-L- FucpNAc biosynthesis; 4th step YP_001296181.1 Probably involved in extracellular polysaccharide biosynthesis YP_001296182.1 Lipopolysaccharide O-antigen biosynthesis; UDP-L- FucpNAc biosynthesis; 1, 2 and 3rd steps YP_001296183.1 Similar to putative rhamnosyl transferase WbuA of Escherichia coli YP_001296184.1 Probable transmembrane protein. Putative transporter involved in extracellular polysaccharide biosynthesis YP_001296185.1 Similar to membrane protein involved in the exportof O-antigen COG2244 YP_001296186.1 Probable transmembrane protein, weakly similar to Eps11O protein of Streptococcus thermophilus YP_001296187.1 Lipopolysaccharide O-antigen biosynthesis; dTDP-L- rhamnose biosynthesis; first step YP_001296188.1 Lipopolysaccharide O-antigen biosynthesis; dTDP-L- rhamnose biosynthesis; second step YP_001296189.1 Lipid A modification with 4-amino-4-deoxy-L- arabinose; step 1 (by similarity) YP_001296190.1 Similar to WbpO protein of Pseudomonas aeruginosa involved in lipopolysaccharide O antigen biosynthetic YP_001296191.1 Similar to WbpP protein of Pseudomonas aeruginosa involved in lipopolysaccharide O antigen biosynthetic YP_001296192.1 Probable transmembrane protein similar to tyrosine- protein kinase Wzc of Escherichia coli YP_001296193.1 Similar to putative capsular polysaccharide transport protein. Probable transmembrane protein YP_001296194.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001296195.1 Solute:Sodium Symporter (SSS) Family, TC 2.A.21.Y.Z YP_001296196.1 Similar to predicted CoA-binding protein COG1832 YP_001296197.1 The 6 TMS Putative MarC Transporter (MarC) Family.TC 9.B.10.Y.Z YP_001296198.1 Similar to uncharacterized protein conserved in bacteria containing a pentein-type domain COG4874 YP_001296200.1 Some similarities with S23 ribosomal protein YP_001296201.1 Similar to N-Dimethylarginine dimethylaminohydrolase COG1834 YP_001296202.1 Tricarboxylic acid cycle YP_001296203.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001296204.1 N-terminal region similar to YbfO protein of Bacillus subtilis and C-terminal region similar to putative outer membrane protein, probably involved in nutrient bindingof Bacteroides sp. YP_001296205.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001296206.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001296207.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001296208.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001296209.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001296210.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001296211.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif YP_001296212.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001296213.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001296214.1 late assembly protein YP_001296215.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001296216.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001296218.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001296219.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001296220.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001296221.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001296222.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001296223.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001296224.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001296225.1 one of the stabilizing components for the large ribosomal subunit YP_001296226.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001296227.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001296228.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001296229.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001296230.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001296231.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001296232.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001296233.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001296234.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_001296235.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001296236.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001296237.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001296238.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296239.1 Similar to outer membrane protein Omp121. TC 1.B.14.6.2 YP_001296240.1 Similar to proteins of unknown function of Bacteroides thetaiotaomicron YP_001296241.1 Similar to rRNA methylases COG0566 YP_001296242.1 Similar to uncharacterized membrane protein COG0705 YP_001296243.1 Similar to ATPase related to the helicase subunit of the Holliday junction resolvase COG2256 YP_001296245.1 Similar to hydrolase, haloacid dehalogenase familyprotein YP_001296246.1 Involved in DNA repair YP_001296247.1 Probably involved in peptidoglycan biosynthesis YP_001296248.1 Contains tetratrico peptide repeat (TPR), a structural motif that mediates protein\u2013protein interactions and the assembly of multiprotein complexes YP_001296249.1 Similar to protein of unknown function of the CFB phylum YP_001296250.1 Similar to protein of unknown function of the CFB phylum YP_001296251.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001296252.1 Similar to hemolysins and related proteins containing CBS domains COG1253 and to putative Mg2+ and Co2+ transporter CorB COG4536 YP_001296253.1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitousenzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth (bysimilarity) YP_001296254.1 Purine salvage YP_001296256.1 De novo purine biosynthesis; sixth step. Possessesan ATPase activity that is dependent on the presence of AIR (aminoimidazole ribonucleotide). The association of purK and purE produces an enzyme complex capable of converting AIR to CAIR efficiently under physiological condition (by similarity) YP_001296257.1 De novo purine biosynthesis; sixth step. This subunit can alone transform AIR to CAIR, but in association with purK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting AIR to CAIR efficiently under physiological condition (by similarity) YP_001296258.1 Removes dipeptides from the C-termini of N- blockedtripeptides, tetrapeptides and larger peptides (by similarity) YP_001296259.1 Similar to tryptophan repeat gene family proteins of Melanoplus sanguinipes entomopoxvirus YP_001296263.1 Probable transmembrane protein YP_001296264.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_001296265.1 Similar to protein of unknown function YP_001296266.1 Fatty acid biosynthesis YP_001296267.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Porphyromonas gingivalis. Probable transmembrane protein YP_001296268.1 Similar to predicted glycosyltransferases COG1216 YP_001296270.1 ABC transporter, permease (IM), MKL-family, import of unknown substrat, TC 3.A.1.Y.Z YP_001296271.1 ABC transporter, ATP-binding protein (ABC), MKL- family, import of unknown substrat, TC 3.A.1.Y.Z YP_001296272.1 Similar to protein of unknown function of Rhodopseudomonas palustris, Pseudomonas syringae and Shewanella oneidensis YP_001296273.1 Involved in the biosynthesis of the capsular polysaccharide colanic acid. GDP-mannose biosynthesis (part of the gene cluster for the M antigen or colanic acid capsular polysaccharide) (by similarity) YP_001296274.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296275.1 Similar to short-chain dehydrogenases YP_001296276.1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity) YP_001296277.1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity) YP_001296278.1 his enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (by similarity) YP_001296279.1 Similar to Fjo23 protein of Flavobacterium johnsoniae YP_001296280.1 Similar to Fjo24 protein of Flavobacterium johnsoniae YP_001296281.1 Highly similar to Flavobacterium johnsoniae lipoprotein GldJ involved in gliding motility YP_001296282.1 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl- pentapeptide, the precursor of murein (By similarity) YP_001296283.1 Similar to protein of unknown function of Flavobacterium psychrophilum YP_001296284.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001296285.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001296287.1 Similar to protein of unknown function of the CFB phylum YP_001296288.1 Similar to 2-methylthioadenine synthetase COG0621 YP_001296289.1 Similar to protein of unknown function of the CFB phylum YP_001296290.1 Start doubtful, the first ATG was choosen. Probable transmembrane protein containing an histidine kinase domain in C-terminal YP_001296291.1 Similar to two-component system response regulatory protein YP_001296292.1 Some similarities with Fe-S oxidoreductase COG1032 YP_001296293.1 Similar to uncharacterized protein conserved in bacteria COG4365 YP_001296294.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001296295.1 Similar to protein of unknown function of Geobacter metallireducens GS-15. Probable exported protein YP_001296296.1 Probable transmembrane protein similar to alginateo- acetyltransferase AlgI YP_001296297.1 Similar to alginate o-acetyltransferase AlgJ YP_001296298.1 Probable transmembrane protein similar to alginateo- acetyltransferase AlgI YP_001296299.1 Similar to protein of unknown function of the CFB phylum YP_001296301.1 Probably involved in peptidoglycan modification (by similarity) YP_001296302.1 Start doubtful, the first ATG was choosen. Glutathione peroxidase (GSHPx), an enzyme whose principal function is to protect against damage from endogenously- formed hydroxyperoxides, catalyses the reduction of hydroxyperoxides by glutathione YP_001296303.1 Probable transmembrane protein YP_001296304.1 Similar to uncharacterized conserved protein COG5495 YP_001296305.1 Lipopolysaccharide biosynthesis; KDO biosynthesis;third step (by similarity) YP_001296306.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin YP_001296307.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001296308.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001296309.1 ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family, export of unknown substrat, TC 3.A.1.Y.Z YP_001296310.1 Dihydrofolate biosynthesis; second step YP_001296311.1 Similar to protein of unknown function of the CFB phylum YP_001296312.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Probable transmembrane protein YP_001296313.1 Thioredoxins are small disulphide-containing redoxproteins that serves as a general protein disulphide oxidoreductase YP_001296314.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_001296315.1 Functional homolog of SRP receptor. Probably involved in the reception and insertion of a subset of proteinsat the cytoplasmic membrane (By similarity) YP_001296317.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001296318.1 required for 70S ribosome assembly YP_001296319.1 Similar to competence-damage inducible protein CinA YP_001296320.1 Similar to exopolyphosphatase COG0248 YP_001296322.1 Some similarities with 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) COG0179 YP_001296323.1 Similar to DNA polymerase III, epsilon subunit andrelated 3'-5' exonucleases COG0847 and C-terminal region similar to nuclease subunit of the excinuclease complex COG0322 YP_001296324.1 Some similarities with peptidyl-prolyl cis-trans isomerase, FKBP-type COG0545 YP_001296325.1 Similar to ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) YP_001296326.1 S-methyltransferase family protein YP_001296327.1 Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine- dependent manner to specific sites on pyr mRNA. Displays also a weak uracil phosphoribosyltransferase activity which is not physiologically significant (by similarity) YP_001296328.1 Aromatic amino acids biosynthesis. Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 5 YP_001296329.1 Carotenoid biosynthesis. Catalyzes the cyclizationreaction which converts lycopene to beta- carotene (By similarity) YP_001296331.1 Carotenoid biosynthesis. This enzyme converts phytoene into lycopene via the intermediaries of phytofluene, zeta-carotene and neurosporene by the introduction of fourdouble bonds (By similarity) YP_001296332.1 Carotenoid biosynthesis. Catalyzes the reaction from prephytoene diphosphate to phytoene (By similarity) YP_001296336.1 Similar to protein of unknown function of the CFB phylum. Probable transmembrane protein. Putative anti ECF- type sigma factor YP_001296337.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released YP_001296338.1 Similar to protein of unknown function of the CFB phylum YP_001296339.1 Outer Membrane Receptor (OMR) Family protein. TC 1.B.14.Y.Z YP_001296340.1 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (by similarity) YP_001296341.1 Cobalamin biosynthesis; last step YP_001296342.1 N-terminal region similar to cobalamin biosynthesis nitroreductase BluB and C-terminal region similar to CobT involved in cobalamin biosynthesis YP_001296343.1 Adenosylcobalamin biosynthesis; last part; sixth step (by similarity) YP_001296344.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296345.1 ABC transporter, binding protein (BP), ISVH-family, iron(III) import (putative), TC 3.A.1.14. Z YP_001296346.1 ABC transporter, permease (IM), ISVH-family, iron(III) import (putative), TC 3.A.1.14. Z YP_001296347.1 Similar to glycosyltransferases , probably involved in cell wall biogenesis COG1215 YP_001296348.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released YP_001296349.1 Probable transmembrane protein YP_001296350.1 Probable transmembrane protein YP_001296351.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001296352.1 Second phase of glycolysis; first step YP_001296353.1 Hybrid sensory kinase containing a response regulator receiver domain in the C-terminal part YP_001296354.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_001296355.1 Lipid A biosynthesis; sixth step YP_001296356.1 Weakly similar to acetyltransferases COG0456 YP_001296357.1 Necessary for the biosynthesis of purines, thymidylate, methionine, histidine, pantothenate, and formyl tRNA-Met YP_001296358.1 Necessary for efficient export of extra-cytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes YP_001296359.1 Similar to predicted thiol oxidoreductase COG3488 YP_001296360.1 Similar to uncharacterized iron-regulated protein COG3487 YP_001296362.1 Some similarities with ankyrin repeat COG0666. Some similarities with eukaryotic proteins YP_001296363.1 Similar to uncharacterized protein related to plant photosystem II stability/assembly factor COG4447 YP_001296364.1 Similar to uncharacterized protein related to plant photosystem II stability/assembly factor COG4447 YP_001296365.1 Probable exported protein YP_001296366.1 Similar to membrane-associated lipoprotein involved in thiamine biosynthesis COG1477 YP_001296367.1 Thioredoxins are small disulphide-containing redoxproteins that serves as a general protein disulphide oxidoreductase YP_001296368.1 Similar to protein of unknown function of Bacteroides fragilis and Cytophaga hutchinsonii YP_001296369.1 Probable lipoprotein. IrpA occurs under iron- deficient growth conditions in cyanobacterium Synechococcus anddisappears in cells recovering from iron starvation. It seems to be involved in iron acquisition, uptake or storage YP_001296370.1 Vitamin K-dependent carboxylation of multiple amino- terminal glutamate residues in various proteins, it converts glutamate residues to gamma-carboxyglutamate (by similarity) YP_001296371.1 ABC transporter, outer membrane receptor (OMR), ISVH-family, Iron(III) dicitrate import, TC 1.B.14.1.2 YP_001296372.1 Similar to acyl-CoA hydrolase COG1607 YP_001296373.1 Some similarities with histidine kinase sensor proteins YP_001296374.1 Similar to protein of unknown function of Flavobacterium psychrophilum YP_001296375.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296376.1 Probable transmembrane protein YP_001296377.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001296378.1 Similar to protein of unknown function of Xanthomonas sp. YP_001296380.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001296381.1 Some weak similarities with hemagglutinin-related protein. Putative exported protein YP_001296382.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001296383.1 Fatty acid biosynthesis YP_001296384.1 Some similarities with protein of unknown functionof Methanosarcina acetivorans. Probable transmembrane protein YP_001296386.1 ABC transporter, ATP-binding protein (ABC), MOI- family, import of unknown substrat, TC 3.A.1.Y.Z YP_001296387.1 Similar to predicted unusual protein kinase COG0661 YP_001296388.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296389.1 Similar to outer membrane protein and related peptidoglycan-associated (lipo)proteins COG2885 YP_001296391.1 molecular chaperone YP_001296392.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001296393.1 Similar to uncharacterized protein conserved in bacteria COG5267 YP_001296394.1 Similar to uncharacterized protein conserved in bacteria COG4102. Probable secreted protein containing a twin-arginine translocation pathway signal sequence domain YP_001296395.1 Similar to Fjo20 protein of Flavobacterium johnsoniae. Probable drug/metabolite transporter (DMT) superfamily protein. TC 2.A.7.Y.Z YP_001296397.1 Similar to protein of unknown function of Flavobacterium psychrophilum YP_001296398.1 Some similarities with two-component sensor histidine kinase LytS YP_001296399.1 Similar to response regulator of the LytR/AlgR family COG3279 YP_001296400.1 Similar to two-component system response regulatory protein RprY YP_001296401.1 Similar to uncharacterized conserved protein COG3513, TIGR01865. HNH endonuclease ? YP_001296402.1 Similar to uncharacterized conserved protein predicted to be a putative novel nuclease COG1518, TIGR00287. YP_001296403.1 Similar to uncharacterized conserved protein COG3512 YP_001296408.1 Similar to protein of unknown function of Bacteroides fragilis YP_001296409.1 Similar to protein of unknown function of Bacteroides fragilis YP_001296410.1 Some similarities with protein of unknown functionof Bacteroides fragilis YP_001296411.1 Similar to uncharacterized conserved protein COG2253 YP_001296412.1 Similar to predicted transcriptional regulator COG5340 YP_001296414.1 Similar to predicted ATPase of Cytophaga hutchinsonii YP_001296415.1 Some similarities with protein of unknown functionof Cytophaga hutchinsonii YP_001296416.1 Similar to protein of unknown function of Bacteroides spp. YP_001296417.1 Similar to tetracycline resistance element mobilization regulatory protein RteC of the CFB phylum YP_001296418.1 Major Facilitator Superfamily (MFS). TC 2.A.1.Y.Z. YP_001296420.1 Resistance to tetracycline via an oxidoreductase activity (By similarity) YP_001296421.1 Similar to AraC-type DNA-binding domain- containingproteins COG2207 YP_001296423.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296424.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296425.1 Highly similar to protein of unknown function of Flavobacterium psychrophilum and some similarities with proteins of unknown function of Desulfotalea psychrophila andPhotobacterium profundum YP_001296426.1 Probable transmembrane protein YP_001296428.1 Similar to hypothetical protein of Flavobacterium psychrophilum YP_001296429.1 Similar to protein of unknown function of Flavobacterium psychrophilum YP_001296430.1 Similar to predicted transcriptional regulator containing an HTH domain and an uncharacterized domain sharedwith the mammalian protein Schlafen COG2865 YP_001296431.1 Similar to putative DNA mismatch repair protein YP_001296433.1 Some similarities with protein of unknown functionof Bacteroides fragilis YP_001296434.1 Weakly similar to predicted ATP-binding protein involved in virulence of Vibrio vulnificus YP_001296436.1 Some similarities with protein of unknown functionof Dechloromonas aromatica RCB YP_001296437.1 Similar to protein of unknown function of Pirellula sp. and Burkholderia fungorum YP_001296438.1 Similar to superfamily I DNA and RNA helicases COG0210 YP_001296439.1 Some similarities with pathogenesis-related protein RL009 of Pseudomonas aeruginosa strain PA14 pathogenicity island PAPI-1 YP_001296441.1 Weakly similar to protein of unknown function of Bacteroides thetaiotaomicron YP_001296443.1 Similar to adenine-specific DNA methylase COG0827 YP_001296445.1 Some similarities with putative transcription regulators YP_001296447.1 Similar to predicted ATPase of Cytophaga hutchinsonii YP_001296448.1 Some similarities with protein of unknown functionof Cytophaga hutchinsonii YP_001296449.1 Similar to protein of unknown function of Bacteroides sp. YP_001296454.1 Similar to uncharacterized protein PaaI, possibly involved in aromatic compounds catabolism COG2050 YP_001296455.1 Similar to protein of unknown function of Acinetobacter sp. YP_001296456.1 Similar to predicted thioesterase COG0824 YP_001296457.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001296458.1 Similar to putative periplasmic ATP/GTP-binding protein of Campylobacter spp. YP_001296459.1 Cofactor biosynthesis; pantothenate biosynthesis; pantoate from 3-methyl-2-oxobutanoate: step 2. Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (by similarity) YP_001296462.1 Similar to protein of unknown function YP_001296463.1 Similar to acetyl-CoA acetyltransferase COG0183 YP_001296464.1 Similar to transcriptional regulator COG1309 YP_001296465.1 Riboflavin biosynthesis YP_001296466.1 Similar to protein of unknown function of the CFB phylum. Probable transmembrane protein YP_001296467.1 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane YP_001296468.1 DNA motor protein, which is both required to move DNA out of the region of the septum during cell division and for the septum formation. Tracks DNA in an ATP- dependent manner by generating positive supercoils in front of it and negative supercoils behind it (By similarity) YP_001296469.1 Recycling of diacylglycerol produced during the turnover of membrane phospholipid (by similarity) YP_001296470.1 Has antioxidant activity. Could remove peroxides or H(2)O(2) (by similarity) YP_001296471.1 Similar to predicted transcriptional regulators COG0640 YP_001296472.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296474.1 S-methyltransferase family protein YP_001296475.1 Reduction of arsenate [As(V)] to arsenite [As(III)] (by similarity) YP_001296476.1 Similar to UDP-3-O-(R-3-hydroxymyristoyl)- glucosamine N-acyltransferase LpxD YP_001296477.1 Menaquinone biosynthesis YP_001296478.1 Similar to protein of unknown function YyaK of B. subtilis. Probable transmembrane protein YP_001296479.1 Reduction of arsenate [As(V)] to arsenite [As(III)] (by similarity) YP_001296480.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001296482.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001296484.1 Some similarities with fucose permease COG0738 YP_001296485.1 Similar to predicted permeases COG2962 and to YojEprotein of B. subtilis YP_001296486.1 Similar to predicted ATPase with chaperone activity COG0606 YP_001296488.1 Similar to predicted N-acetylglucosamine kinase COG2971 YP_001296489.1 Second phase of glycolysis; first step (by similarity) YP_001296490.1 Key control step of glycolysis YP_001296491.1 Similar to protein of unknown function of the CFB phylum. Probable exported protein YP_001296492.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001296493.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001296494.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Xanthomonas sp. YP_001296496.1 Similar to predicted permease COG0628 YP_001296497.1 Similar to protein of unknown function of the CFB phylum YP_001296499.1 Hydrolyzes D-Ala-D-Ala. May have a role in cell- wall turnover (by similarity) YP_001296500.1 Similar to putative lipoprotein of Streptomyces sp. YP_001296501.1 Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1 (by similarity) YP_001296502.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (by similarity) YP_001296503.1 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm, thereby maintaining the active site of dsbC, dsbE and dsbG in a reduced state. YP_001296504.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_001296506.1 Similar to lipopolysaccharide core biosynthesis protein LpsA of Bacteroides sp. YP_001296507.1 Similar to glycosyltransferase COG0438 YP_001296509.1 Some similarities with predicted xylanase/chitin deacetylase COG0726 YP_001296510.1 Similar to glycosyltransferases involved in cell wall biogenesis COG0463 YP_001296511.1 Similar to protein of unknown function of the CFB phylum. Probable transmembrane protein YP_001296512.1 Similar to protein of unknown function of the CFB phylum YP_001296513.1 Similar to protein of unknown function WbhW of Escherichia coli YP_001296514.1 Similar to glycosyltransferase involved in cell wall biogenesis COG0463 YP_001296516.1 First of the three steps in the biosynthesis of GDP- fucose from GDP-mannose (by similarity) YP_001296517.1 Similar to rmd of Xanthomonas campestris probably involved in lipopolysaccharide core biosynthesis YP_001296518.1 Similar to putative beta-glucosyltransferase cpsI of Streptococcus salivarius probably involved in exopolysaccharide biosynthesis YP_001296519.1 Similar to putative translation factor (SUA5) COG0009 YP_001296520.1 This enzyme carries out synthesis of the tRNA CCA terminus without the direction of a template using the multiple accepting and donating subsites within its active site (by similarity) YP_001296521.1 Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono- oxygenase consisting of CoxA, ferredoxin and ferredoxin reductase (by similarity) YP_001296522.1 Probable transmembrane protein probably involved in phospholipid biosynthesis YP_001296524.1 Similar to protein of unknown function of Bacilluscereus. Probable transmembrane protein YP_001296525.1 Similar to protein of unknown function of Bacilluscereus. Probable transmembrane protein YP_001296526.1 Probable transmembrane protein YP_001296528.1 Similar to protein of unknown function of Porphyromonas gingivalis YP_001296529.1 Probable outer membrane receptor protein YP_001296531.1 Some weak similarities with cell surface protein YP_001296532.1 Similar to protein of unknown function of the CFB phylum YP_001296533.1 Similar to protein of unknown function YP_001296534.1 Similar to protein of unknown function YP_001296535.1 ABC transporter, ATP-binding protein (ABC), DRI- family, LAI-subfamily, drug export (putative), TC 3.A.1.Y.Z YP_001296536.1 ABC transporter, permease (IM), DRI-family, LAI- subfamily, drug export (putative), TC 3.A.1.Y.Z YP_001296537.1 Some similarities with hemagglutinin-related protein YP_001296538.1 Some weak similarities with protein of unknown function of the CFB phylum. Probable exported protein YP_001296539.1 Highly similar to gliding motility protein GldD ofFlavobacterium johnsoniae, a probable cytoplasmic membrane protein YP_001296540.1 Highly similar to Ssb protein of Flavobacterium johnsoniae YP_001296541.1 Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past go lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (by similarity) YP_001296542.1 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions (by similarity) YP_001296543.1 Involved in the processing of the 5'end of 16S rRNA. Could be involved in chromosome segregation and cell division. It may be one of the components of the cytoplasmicaxial filaments bundles or merely regulate the formation of this structure (by similarity) YP_001296544.1 Similar to ATPases involved in chromosome partitioning COG0489 YP_001296545.1 Similar to thioredoxin-like proteins and domains COG0694 YP_001296547.1 Some weak similarities with proteins of unknown function YP_001296548.1 Similar to Fjo11 protein of Flavobacterium johnsoniae. Probable transmembrane protein YP_001296549.1 Weakly similar to protein of unknown function of Brucella sp. and Rhizobium loti YP_001296550.1 Menaquinone biosynthesis; first step (by similarity) YP_001296551.1 Similar to sortase and related acyltransferases COG1247 YP_001296552.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_001296553.1 Weakly similar to uncharacterized conserved protein COG2127 YP_001296554.1 Probable transmembrane protein YP_001296556.1 Similar to predicted membrane protein COG3714 YP_001296557.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Deinococcus radiodurans. Probable transmembrane protein YP_001296558.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Deinococcus radiodurans. Probable transmembrane protein YP_001296559.1 Some similarities with fibril protein of Myxococcus xanthus YP_001296560.1 Similar to uncharacterized conserved protein COG1284. Probable transmembrane protein YP_001296561.1 Probably involved in the regulation of the kdp operon YP_001296562.1 Probably involved in the regulation of the kdp operon YP_001296563.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296564.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex YP_001296565.1 One of the components of the high-affinity ATP- driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogenand potassium ions (by similarity) YP_001296566.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001296568.1 Similar to response regulator containing CheY- likereceiver, AAA-type ATPase, and DNA-binding domains COG2204 YP_001296569.1 Putative heme binding lipoprotein YP_001296570.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_001296571.1 Similar to protein of unknown function of the CFB phylum YP_001296572.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001296573.1 Probable exported protein similar to protein of unknown function of Flavobacterium psychrophilum YP_001296574.1 Similar to arginase/agmatinase/formimionoglutamatehydrolase, arginase family COG0010 YP_001296575.1 Similar to superfamily II DNA and RNA helicase COG0513 YP_001296576.1 Probable transmembrane protein. The exact molecular function of this protein is uncertain (by similarity) YP_001296577.1 Similar to protein of unknown function. Probable transmembrane protein YP_001296578.1 De novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate. Oxidizes PNP and PMP into pyridoxal 5'-phosphate (PLP) (by similarity) YP_001296579.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_001296580.1 Similar to carbapenem antibiotics biosynthesis protein and proline dehydrogenase. Probably involved in antibiotic resistance YP_001296581.1 Aromatic amino acids biosynthesis. Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 2 (by similarity) YP_001296582.1 Putrescine and spermidine biosynthesis from arginine; first step. YP_001296583.1 Similar to eukaryotic deoxyhypusine synthase COG1899 YP_001296585.1 Transports nucleosides with a high affinity. Driven by a proton motive force (by similarity). TC 2.1.A.10 .Z YP_001296586.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001296587.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Porphyromonas gingivalis YP_001296588.1 Degrades short-lived regulatory and abnormal proteins in presence of ATP. Degrades the regulatory proteins rcsA and sulA. Hydrolyzes two ATPs for each peptide bond cleaved in the protein substrate (by similarity) YP_001296589.1 Major Facilitator Superfamily (MFS). TC 2.A.1.Y.Z YP_001296590.1 Similar to Zn-dependent protease with chaperone function COG0501. Probable lipoprotein YP_001296591.1 Similar to predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) COG0596 YP_001296594.1 Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids (by similarity) YP_001296595.1 GGT plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione(by simillarity) YP_001296596.1 Similar to transcriptional regulators COG1846 YP_001296598.1 Similar to protein of unknown function YP_001296599.1 Lipid catabolism; beta-oxidation cycle; from acyl- CoA: step C (by similarity) YP_001296602.1 Thioredoxins are small disulphide-containing redoxproteins that serves as a general protein disulphide oxidoreductase YP_001296603.1 Similar to peroxiredoxin COG0450. Peroxiredoxins are a ubiquitous family of antioxidant proteins YP_001296604.1 Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide YP_001296605.1 Some weak similarities with putative lipase YP_001296606.1 Amino Acid-Polyamine-Organocation (APC) Superfamily. TC 2.A.3.Y.Z YP_001296608.1 Similar to transcriptional regulator COG1522 YP_001296609.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide. Component of two multienzyme complexes: pyruvate dehydrogenase complex and oxoglutarate dehydrogenase complex. YP_001296610.1 Cu-Zn; copper/zinc; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (bysimilarity) YP_001296612.1 Hydrogen peroxide sensor. Activates the expressionof a regulon of hydrogen peroxide-inducible genes (by similarity) YP_001296613.1 Similar to protein of unknown function of Flavobacterium psychrophilum YP_001296614.1 Similar to uncharacterized conserved protein COG4121 YP_001296615.1 Similar to branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase COG0115 YP_001296616.1 Similar to uncharacterized conserved protein COG4696 YP_001296618.1 Probable exported protein YP_001296619.1 Similar to dinucleotide-utilizing enzymes involvedin molybdopterin and thiamine biosynthesis family 1 COG1179 YP_001296620.1 Similar to Mg-dependent DNase COG0084 YP_001296621.1 Similar to uncharacterized conserved protein COG3358 YP_001296622.1 Major Facilitator Superfamily (MFS). TC 2.A.1.Y.Z. YP_001296623.1 Similar to predicted transcriptional regulator COG3682. Probable repressor YP_001296624.1 Some similarities with antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component COG4219 YP_001296625.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001296626.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_001296627.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001296628.1 Similar to protein of unknown function of the CFB phylum YP_001296629.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_001296630.1 Similar to predicted hydrolase of the alpha/beta superfamily COG2819 YP_001296631.1 C-terminal region similar to AraC-type DNA- bindingdomain-containing proteins COG2207 YP_001296632.1 Similar to uncharacterized protein, possibly involved in utilization of glycolate and propanediol COG3193 YP_001296635.1 Similar to PI-irrepressible alkaline phosphatase PafA of Flavobacterium meningosepticum YP_001296636.1 Similar to dioxygenases related to 2-nitropropane dioxygenase COG2070 YP_001296637.1 Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides (by similarity) YP_001296638.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001296639.1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with dnaK, dnaJ and grpE. Acts before dnaK, in the processing of protein aggregates (by similarity) YP_001296640.1 Similar to protein of unknown function of the CFB phylum YP_001296641.1 Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate YP_001296642.1 Similar to predicted SAM-dependent methyltransferase COG3129 YP_001296643.1 Aromatic amino acids biosynthesis. Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4 (by similarity) YP_001296644.1 Contains tetratrico peptide repeat (TPR), a structural motif that mediates protein\u2013protein interactions and the assembly of multiprotein complexes YP_001296645.1 Arginine biosynthesis; fourth step and L-lysine biosynthesis via DAP pathway; LL-diaminopimelate from tetrahydrodipicolinate (succinylase route): step 2 (by similarity) YP_001296646.1 Similar to protein of unknown function of the CFB phylum YP_001296647.1 Similar to chloride channel protein EriC COG0038. TC 1.A.11.Y.Z YP_001296648.1 This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied. It probably acts in the regulation of internal pH at the alkaline pH range. It catalyzes the exchange of 2 H(+) per Na(+). Its activity is highly dependent on the pH (by similarity) YP_001296649.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001296650.1 Similar to predicted membrane protein COG4420 YP_001296651.1 Metal Ion Transporter (MIT) family protein, TC 1.A.35 YP_001296652.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_001296653.1 Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Although the function of this ferredoxin is unknown it is probable that it has a role as a cellular electron transfer protein. Involved in the in vivo assembly of the Fe-S clustersin a wide variety of iron-sulfur proteins (by similarity) YP_001296654.1 Iron-storage protein (by similarity) YP_001296655.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296656.1 Similar to protein of unknown function of Bacteroides fragilis YP_001296657.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001296658.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296660.1 Involved in the conversion of glucose to GDP-L- fucose, which can be converted to L-fucose, a capsular polysaccharide (by similarity) YP_001296661.1 Similar to peroxiredoxin Q of eukaryotes. Peroxiredoxins are a ubiquitous family of antioxidant proteins YP_001296662.1 Tetrahydrobiopterin biosynthesis; second step YP_001296663.1 Isoprenoid biosynthesis; dimethylallyl-PP biosynthesis; dimethylallyl-PP from isopentenyl-PP: single step [final step] (by similarity) YP_001296664.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001296666.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001296667.1 Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine- dependent manner to specific sites on pyr mRNA. Displays also a weak uracil phosphoribosyltransferase activity which is not physiologically significant (by similarity) YP_001296668.1 Similar to glycosyltransferase COG0438 YP_001296669.1 Function not known. In E. coli overproduction leads to camphor resistance and chromosome condensation; deletion increases sensibility to nucleoid decondensation. Probably interacts with the heat-shock protein cspE, possibly providing a way to anchor the chromosome to the membrane YP_001296670.1 Similar to protein of unknown function of the CFB phylum. Probable transmembrane protein YP_001296673.1 Similar to protein of unknown function YghO of Escherichia coli YP_001296676.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001296677.1 Modulates the activities of several enzymes which are inactive in their acetylated form (By similarity) YP_001296678.1 Similar to SpoU, rRNA methylases COG0566 YP_001296679.1 Weakly similar to protein of unknown function YP_001296680.1 Resistance-Nodulation-Cell Division (RND) Superfamily. Probable transmembrane protein. TC 2.A.6.2.Z YP_001296681.1 Membrane Fusion Protein (MFP) Family. Probable lipoprotein. TC 8.A.1.Y.Z YP_001296682.1 Outer Membrane Factor (OMF) Family. TC 1.B.17.Y.Z YP_001296683.1 Thioredoxins are small disulphide-containing redoxproteins that serves as a general protein disulphide oxidoreductase YP_001296684.1 Probable transmembrane protein YP_001296685.1 Similar to rhodanese-like domain protein function of Porphyromonas gingivalis YP_001296686.1 N-terminal region similar to Similar to Zn- dependent hydrolases, including glyoxylases COG0491 and C- terminal region similar to rhodanese-related sulfurtransferase COG0607 YP_001296687.1 Similar to protein of unknown function. Probable transmembrane protein YP_001296688.1 Some similarities with putative outer membrane protein, probably involved in nutrient binding of Bacteroidesthetaiotaomicron YP_001296689.1 Similar to superfamily II DNA and RNA helicases COG0513 YP_001296690.1 hydrolyzes non-standard nucleotides such as xanthine and inosine YP_001296691.1 GMP biosynthesis from IMP; first step (by similarity) YP_001296693.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001296696.1 Start doubtful, the first ATG was choosen. Similarto ypothetical protein YtxJ of Bacillus subtilis YP_001296697.1 Member of the two-component regulatory system RprX/RprY (by similarity) YP_001296698.1 Member of the two-component regulatory system RprX/RprY. May activate RprY by phosphorylation (by similarity) YP_001296699.1 Coenzyme A (CoA) biosynthesis; fifth (last) step. Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) YP_001296700.1 Similar to glycosyltransferases COG0463 COG1215 COG1216 YP_001296701.1 Putative adhesine YP_001296702.1 Purine and pyrimidine metabolism YP_001296703.1 Some similarities with 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases COG0737 YP_001296705.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001296706.1 Similar to putative lipoprotein of the CFB phylum YP_001296707.1 Similar to protein of unknown function of the CFB phylum YP_001296708.1 Coenzyme A (CoA) biosynthesis; second and third steps (by similarity) YP_001296709.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Porphyromonas gingivalis YP_001296710.1 May be involved in recombinational repair of damaged DNA (by similarity) YP_001296711.1 enzyme from Treponema denticola exhibits NADH-dependent trans-2-enoyl-CoA reductase activity YP_001296714.1 Probable transmembrane protein YP_001296715.1 Probable transmembrane protein YP_001296716.1 This protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'- hydroxyl groupsin double-stranded DNA using NAD as a coenzyme and as theenergy source for the reaction. It is essential for DNA replication and repair of damaged DNA (by similarity) YP_001296717.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296718.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001296719.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001296720.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001296721.1 Similar to response regulator of the LytR/AlgR family COG3279 YP_001296722.1 Recognizes a specific hairpin sequence on phiX ssDNA. This structure is then recognized and bound by proteins priB and priC. Formation of the primosome proceeds with the subsequent actions of dnaB, dnaC, dnaT and primase. PriA then functions as a helicase within the primosome (by similarity) YP_001296723.1 Similar to uncharacterized protein conserved in bacteria COG4731 YP_001296724.1 Similar to YfkH protein (Ribonuclease BN) of Bacillus subtilis. Probable transmembrane protein YP_001296725.1 NAD biosynthesis; aspartate to NaMN; third (last) step (by similarity) YP_001296726.1 Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) YP_001296727.1 Similar to predicted transcriptional regulator COG1959 YP_001296728.1 Probable transmembrane protein YP_001296729.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001296730.1 Similar to predicted glycosyltransferases COG1216 YP_001296731.1 Similar to glycosyltransferases COG0463 COG1215 COG1216 YP_001296732.1 Similar to WcgF and WcgG of Bacteroides fragilis. Putative sugar isomerase YP_001296733.1 Similar to glycosyltransferase COG0438 YP_001296734.1 Similar to putative glycosyl transferase WbsE of the Shiga toxin-producing Escherichia coli (STEC) O91 YP_001296735.1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (by similarity) YP_001296736.1 Similar to rRNA methylases COG0566 YP_001296737.1 Similar to predicted membrane protein COG2860. Probable transmembrane protein YP_001296738.1 Similar to protein of unknown function of Xanthomonas axonopodis and Treponema denticola YP_001296739.1 Probable aminotransferase involved in cell wall biogenesis. Similar to WbtC protein of Escherichia coli O103 YP_001296740.1 Probable lipopolysaccharide biosynthesis protein. Probable transmembrane protein YP_001296741.1 Converts isocitrate to alpha ketoglutarate YP_001296742.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001296743.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001296745.1 ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family, HLY-subfamily, drug export, TC 3.A.1.Y.Z YP_001296747.1 Similar to arylsulfatase regulator (Fe-S oxidoreductase) COG0641 YP_001296748.1 Similar to hypothetical protein of Flavobacterium psychrophilum YP_001296749.1 Similar to hypothetical protein of Flavobacterium psychrophilum YP_001296750.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001296751.1 Start doubtful, the first ATG was choosen. Removesdipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides (by similarity) YP_001296752.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001296753.1 Similar to protein of unknown function and some similarities with uncharacterized conserved protein COG4628 YP_001296754.1 Acetylation of N-terminal amino-acid of ribosomal protein YP_001296755.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296756.1 Some similarities with aminopeptidase N COG0308 YP_001296757.1 Start doubtful, the first ATG was choosen. Contains phosphatidylinositol-specific phospholipase C, X domain YP_001296758.1 Similar to PpiB protein of Flavobacterium johnsonae, a probable peptidyl-prolyl cis-trans isomerase YP_001296759.1 Similar to PpiA protein of Flavobacterium johnsonae, a probable peptidyl-prolyl cis-trans isomerase YP_001296760.1 In Flavobacterium johnsoniae, GldI is a lipoprotein that is required for gliding motility and chitin utilization YP_001296761.1 Similar to Fjo19 protein of Flavobacterium johnsoniae and to exopolyphosphatase-related proteins COG0618 YP_001296762.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001296763.1 Similar to LysM domain protein of the CFB phylum YP_001296764.1 Similar to LysM domain protein of the CFB phylum YP_001296765.1 Similar to putative stress-induced protein OsmC YP_001296766.1 Similar to uncharacterized protein conserved in bacteria COG3530 YP_001296767.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001296768.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_001296769.1 Similar to uncharacterized protein conserved in bacteria COG2849 YP_001296770.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001296771.1 Transcriptional repressor of iron transport YP_001296772.1 Probable exported protein YP_001296773.1 Similar to putative periplasmic protein YP_001296774.1 Probable transmembrane protein similar to alginateo- acetyltransferase AlgI YP_001296775.1 Similar to putative periplasmic protein YP_001296776.1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides YP_001296777.1 Catalyzes the methyl esterification of L- isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L- asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. This enzyme does not act on D-aspartyl residues (by similarity) YP_001296778.1 Similar to predicted dehydrogenases and related proteins COG0673 YP_001296780.1 Similar to uncharacterized conserved protein YP_001296781.1 Similar to predicted enzyme with a TIM-barrel foldCOG0325 YP_001296782.1 Similar to protein of unknown function of Chlorobium phaeobacteroides and Nostoc sp. YP_001296783.1 N-terminal region similar to DNA polymerase III, epsilon subunit and related 3'-5' exonucleases COG0847 and C-terminal region similar to nuclease subunit of the excinuclease complex COG0322 YP_001296784.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001296787.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_001296788.1 C-terminal region similar to Outer membrane protein A (OmpA) YP_001296789.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001296790.1 This receptor binds the ferrichrome-iron ligand. It interacts with the TonB protein, which is responsible for energy coupling of the ferrichrome-promoted iron transport system (by similarity) YP_001296791.1 Similar to uncharacterized protein conserved in bacteria COG3295. Probable transmembrane protein YP_001296792.1 Probable exported protein YP_001296793.1 Similar to glutamate dehydrogenase/leucine dehydrogenase COG0334 YP_001296794.1 Similar to protein of unknown function YP_001296795.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_001296797.1 This dipeptidase has specificity for the unusual dipeptide beta-alanyl-L-histidine (by similarity) YP_001296798.1 Probable transmembrane protein, similar to proteinof unknown function of Clostridium thermocellum, Bacillusclausii and Bacteroides sp. YP_001296799.1 Transfer of electrons from NADH to the respiratorychain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation (by similarity) YP_001296800.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released YP_001296801.1 Probable transmembrane protein YP_001296802.1 Probable phospholipid/glycerol acyltransferase YP_001296803.1 MutT/nudix family protein YP_001296805.1 Similar to protein of unknown function YP_001296806.1 Similar to protein of unknown function of Bacteroides fragilis. Weakly similar to plasmid stabilization system protein ParE YP_001296808.1 Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates (by similarity) YP_001296809.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001296810.1 Similar to putative transmembrane peptidase of Bacteroides YP_001296811.1 Similar to predicted transcriptional regulators COG0789 YP_001296812.1 Probable transmembrane protein. The exact molecular function of this protein is uncertain (by similarity) YP_001296813.1 Similar to protein of unknown function DUF477 YP_001296814.1 Similar to beta-propeller domains of methanol dehydrogenase type COG1512. Probable transmembrane protein YP_001296815.1 Similar to protein of unknown function of Photorhabdus luminescens YP_001296816.1 Similar to protein of unknown function of Photorhabdus luminescens and Mycoplasma mycoides subsp. mycoides SC. Probable transmembrane protein YP_001296817.1 Similar to uncharacterized protein conserved in bacteria COG5293 YP_001296818.1 ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family, drug export, TC 3.A.1.Y.Z YP_001296820.1 Similar to protein of unknown function of the CFB phylum YP_001296821.1 Probable exported protein YP_001296822.1 phenylalanine 4-hydroxylase; catalyzes the formation of 4a-hydroxytetrahydrobiopterin and tyrosine from phenylalanine and tetrahydrobiopterin YP_001296823.1 Similar to putative lipoproteins YP_001296825.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_001296826.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Bacteroides fragilis YP_001296827.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Probable exported protein YP_001296828.1 Similar to protein of unknown function of the CFB phylum YP_001296829.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001296830.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001296831.1 Similar to DnaJ-class molecular chaperone with C- terminal Zn finger domain of Cytophaga hutchinsonii YP_001296832.1 Similar to protein of unknown function of Xylella fastidiosa YP_001296833.1 ABC2 type, ART family, REG subfamily protein, probably involved in regulation of translation initiation YP_001296834.1 Start doubtful. Similar to protein of unknown function of Cytophaga hutchinsonii. Probable transmembrane protein YP_001296835.1 Similar to Fjo30 protein of Flavobacterium johnsoniae YP_001296836.1 Highly similar to gliding motility protein GldN ofFlavobacterium johnsoniae, a probable periplasmic protein YP_001296837.1 Highly similar to gliding motility protein GldM ofFlavobacterium johnsoniae, a probable periplasmic protein YP_001296838.1 Highly similar to gliding motility protein GldL ofFlavobacterium johnsoniae YP_001296839.1 Highly similar to gliding motility protein GldK ofFlavobacterium johnsoniae, a probable lipoprotein YP_001296840.1 Similar to Fjo29 protein of Flavobacterium johnsoniae. Weakly similar to arginase/agmatinase/formimionoglutamate hydrolase, arginase family protein YP_001296841.1 The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another YP_001296842.1 Weakly similar to protein of unknown function YP_001296843.1 Similar to protein of unknown function YP_001296844.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Probable exported protein YP_001296845.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001296846.1 Similar to transcriptional regulator of the CFB phylum YP_001296847.1 Similar to protein of unknown function of the CFB phylum YP_001296848.1 Similar to protein of unknown function of the CFB phylum YP_001296849.1 Involved in protein export. Participates in an early event of protein translocation (by similarity) YP_001296850.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001296851.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001296852.1 Probable transmembrane protein YP_001296853.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_001296854.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001296855.1 Inward rectifier potassium channels are characterized by a greater tendancy to allow potassium to flow into the cell rather than out of it (by similarity) YP_001296856.1 Similar to acyl-CoA hydrolase COG1607 YP_001296857.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Geobacter metallireducens. Probable exported protein YP_001296858.1 Involved in DNA recombination (By similarity) YP_001296859.1 Similar to 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases COG1187 YP_001296860.1 Similar to predicted rRNA methylase (SpoU class) COG0219 YP_001296861.1 ABC transporter, ATP-binding protein (ABC), ISVH- family, iron(III) import (putative), TC 3.A.1.14. Z YP_001296862.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001296863.1 Asparagine biosynthesis YP_001296864.1 Similar to glycosyltransferases COG0438 YP_001296865.1 Similar to uncharacterized conserved protein COG5587 YP_001296866.1 N-terminal region similar to rhodanese-related sulfurtransferase COG0607 and C-terminal region similar to thioredoxins YP_001296867.1 The recF protein is involved in DNA metabolism; itis required for DNA replication and normal SOS inducibility. RecF binds preferentially to single- stranded, linear DNA. It also seems to bind ATP (by similarity) YP_001296868.1 Similar to protein of unknown function of the CFB phylum. Probable transmembrane protein. Contains tetratrico peptide repeat (TPR), a structural motif that mediates protein\u2013protein interactions and the assembly of multiprotein complexes YP_001296869.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001296870.1 Similar to protein of unknown function of the CFB phylum YP_001296871.1 Similar to branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase COG0115 YP_001296872.1 Similar to putative transcriptional regulator COG1678 YP_001296873.1 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions (by similarity) YP_001296874.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_001296875.1 Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase (by similarity) YP_001296876.1 Similar to predicted ATPase COG3911 YP_001296878.1 Similar to protein of unknown function of the CFB phylum YP_001296879.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001296880.1 Catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N- acetylglucosamine (GlcNAc) YP_001296881.1 Weakly similar to predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) COG0596 YP_001296882.1 Similar to protein of unknown function of the CFB phylum YP_001296883.1 Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 3 (by similarity) YP_001296885.1 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convertdimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) YP_001296886.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001296887.1 ABC transporter, permease (IM), o228-family, import of unknown substrat, TC 3.A.1.Y.Z YP_001296888.1 Methylates the translation termination release factor RF1 on Gln-235 and RF2 on Gln-252 (by similarity) YP_001296889.1 Similar to hypothetical acetyltransferase YjgM of E. coli YP_001296890.1 Diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino)uracil reductase involved in riboflavin biosynthesis; second and third step YP_001296891.1 Similar to predicted hydrolase (HAD superfamily) COG1011 YP_001296892.1 Similar to uncharacterized conserved protein COG1739 YP_001296893.1 Similar to uncharacterized membrane-associated protein, DedA family COG0586. Probable transmembrane protein YP_001296894.1 Reversible hydration of carbon dioxide YP_001296895.1 Sulfate permease (SulP) Family. TC 2.A.53.Y.Z YP_001296897.1 Similar to putative cation transport ATPase of Cytophaga hutchinsonii YP_001296898.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001296900.1 Probable transmembrane protein YP_001296901.1 Probable transmembrane protein YP_001296902.1 Similar to GAF domain-containing proteins COG1956 YP_001296903.1 Similar to protein of unknown function YP_001296904.1 Some similarities with eukaryotic proteins of unknown function YP_001296905.1 Similar to conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family COG1853 YP_001296906.1 This enzyme catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand, upon exposure to ultraviolet radiation YP_001296907.1 Similar to uncharacterized protein related to deoxyribodipyrimidine photolyase COG3046 YP_001296908.1 This enzyme catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand, upon exposure to ultraviolet radiation YP_001296909.1 Some similarities with predicted nucleoside- diphosphate-sugar epimerases COG0702 YP_001296910.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001296911.1 Involved in mRNA degradation. Hydrolyzes single- stranded polyribonucleotides processively in the 3' to 5' direction. Involved in the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation (by similarity) YP_001296913.1 Belongs to the sigma-70 factor family YP_001296915.1 Similar to uncharacterized protein conserved in bacteria COG3228. Probable exported protein YP_001296916.1 Similar to uncharacterized protein conserved in bacteria COG1610 YP_001296917.1 This protein is essential to the cell-division process. It seems to assemble into a dynamic ring on the inner surface of the cytoplasmic membrane at the place where division will occur, and the formation of the ring is the signal for septation to begin. Binds to and hydrolyzes GTP (by similarity) YP_001296918.1 This protein may be involved in anomalous filamentgrowth. May be a component of the septum. It may interactwith ftsZ (By similarity) YP_001296919.1 This protein may be involved in septum formation YP_001296920.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001296921.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001296922.1 This is a septum-peptidoglycan biosynthetic protein, involved in cell wall formation. Plays a role in the stabilization of the ftsZ ring during cell division. Integral membrane protein. Inner membrane YP_001296923.1 Cell wall formation. Peptidoglycan biosynthesis (by similarity) YP_001296924.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001296925.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001296926.1 Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates. Peptidoglycan synthesis; final stages (by similarity) YP_001296928.1 Exhibits a S-adenosyl-dependent methyltransferase activity (by similarity) YP_001296929.1 Homooctamer. Forms a ring (by similarity) YP_001296930.1 Probably involved in phenylalanine metabolism YP_001296931.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001296932.1 Highly similar to gliding motility protein GldC ofFlavobacterium johnsoniae YP_001296933.1 Highly similar to gliding motility protein GldB ofFlavobacterium johnsoniae YP_001296934.1 NAD biosynthesis YP_001296935.1 Two-component system response regulatory protein containing receiver domain and LuxR-type DNA-binding domain YP_001296936.1 DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (by similarity) YP_001296937.1 Similar to proteins of unknown function of Flavobacterium psychrophilum. Some similarities with proteins of unknown function YP_001296938.1 Similar to proteins of unknown function of Flavobacterium psychrophilum. Some similarities with proteins of unknown function YP_001296939.1 Probable exported protein YP_001296940.1 Probable transmembrane protein. Putative anti ECF- type sigma factor YP_001296941.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released YP_001296942.1 Similar to geranylgeranyl pyrophosphate synthase COG0142 YP_001296944.1 Similar to protein of unknown function YloN of B. subtilis. Predicted Fe-S-cluster redox enzyme YP_001296945.1 Similar to predicted O-methyltransferase COG4122 YP_001296946.1 Probable transmembrane protein YP_001296948.1 binds and unfolds substrates as part of the ClpXP protease YP_001296949.1 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. May play the role of a master protease which is attracted to different substrates by different specificity factors such as clpA or clpX (by similarity) YP_001296950.1 Involved in protein export. Acts as a chaperone bymaintaining the newly synthesized protein in an open conformation (by similarity) YP_001296951.1 Similar to protein of predicted membrane protein COG1950 YP_001296952.1 Similar to predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) COG0596 YP_001296953.1 ABC transporter, permease (IM), export of unknownsubstrat, TC 3.A.1.Y.Z YP_001296954.1 ABC transporter, ATP-binding protein (ABC), DRI- family, DRB-subfamilly, export of unknown substrat, TC 3.A.1.Y.Z YP_001296955.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_001296956.1 Similar to CBS domain protein of Cytophaga hutchinsonii YP_001296957.1 catalyzes the phosphorylation of NAD to NADP YP_001296958.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001296959.1 Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide (by similarity) YP_001296960.1 Similar to outer membrane protein/protective antigen OMA87 COG4775 YP_001296961.1 N-terminal region similar to outer membrane protein (OmpH-like) COG2825 YP_001296962.1 Outer membrane protein (OmpH-like) COG2885 YP_001296963.1 Peptidoglycan biosynthesis. Provides the (R)- glutamate required for cell wall biosynthesis (by similarity) YP_001296964.1 Similar to carbonic anhydrases/acetyltransferases,isoleucine patch superfamily COG0663 YP_001296965.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Porphyromonas gingivalis YP_001296966.1 Some similarities with thioredoxin-like proteins and domains COG0694 YP_001296967.1 Similar to highly conserved protein containing a thioredoxin domain YyaL of B. subtilis YP_001296968.1 Some weak similarities with protein of unknown function of Neurospora crassa YP_001296969.1 Similar to inactive homolog of metal-dependent proteases, putative molecular chaperone COG1214 YP_001296970.1 Converts protoheme IX and farnesyl diphosphate to heme O YP_001296971.1 Similar to heme/copper-type cytochrome/quinol oxidase, subunit 3 COG1845 YP_001296972.1 Similar to heme/copper-type cytochrome/quinol oxidase, subunit 3 COG1845 YP_001296973.1 Probable transmembrane protein YP_001296974.1 Probable transmembrane protein YP_001296975.1 Similar to uncharacterized protein SCO1/SenC/PrrC,involved in biogenesis of respiratory and photosynthetic systems COG1999 YP_001296976.1 Similar to protein of unknown function YozB of B. subtilis YP_001296977.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Probable transmembrane protein YP_001296978.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Trichodesmium erythraeum YP_001296979.1 Outer Membrane Factor (OMF) Family. TC 1.B.17.Y.Z YP_001296980.1 Membrane Fusion Protein (MFP) Family. Probable transmembrane protein. TC =8.A.1.Y.Z YP_001296981.1 Some similarities with proteins of unknown function of Cytophaga hutchinsonii YP_001296982.1 Nucleotide and deoxyribonucleotide catabolism YP_001296983.1 Similar to fjo27 protein of Flavobacterium johnsoniae. Probable transmembrane protein YP_001296984.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_001296985.1 Similar to SprA protein involved in gliding motility and chitin utilization of Flavobacterium johnsoniae. Probable exported protein YP_001296986.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001296987.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_001296988.1 Similar to uncharacterized Fe-S protein COG1600 YP_001296989.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001296990.1 Amino Acid-Polyamine-Organocation (APC) Superfamily protein. TC 2.A.3.Y.Z YP_001296991.1 Some similarities with aminopeptidase N COG0308 YP_001296994.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family YP_001296995.1 Similar to YitI protein of Bacillus sp. YP_001296996.1 Similar to uncharacterized protein conserved in bacteria COG2989 YP_001296997.1 Similar to uncharacterized protein conserved in bacteria YP_001296998.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_001297000.1 Similar to type I restriction-modification system methyltransferase subunit COG0286 YP_001297001.1 Similar to protein of unknown function of the CFB phylum YP_001297002.1 Putative lipoprotein YP_001297003.1 Weakly similar to protein of unknown function of Xanthomonas campestris and Haemophilus influenzae YP_001297004.1 Probable Drug:H+ Antiporter-1 (12 Spanner) (DHA1) Family Protein. TC : 2.A.1.2.Z YP_001297005.1 Probable transmembrane protein YP_001297010.1 Similar to type I restriction-modification system methyltransferase subunit COG0286 YP_001297013.1 Similar to site-specific DNA methylase COG0270. Probable DNA (cytosine-5-)-methyltransferase YP_001297014.1 Probable transmembrane protein YP_001297015.1 Probable transmembrane protein YP_001297016.1 Some similarities with protein of unknown functionof Leptospira interrogans YP_001297017.1 Some weak similarities with protein of unknown function of Cytophaga hutchinsonii YP_001297018.1 Some weak similarities with protein of unknown function of Cytophaga hutchinsonii. Probable transmembrane potein YP_001297019.1 Some similarities with TonB protein YP_001297022.1 Similar to uncharacterized conserved protein COG3177 YP_001297023.1 Probable pseudogene, some similarities with protein of unknown function YP_001297024.1 Some weak similarities with protein of unknown function of Synechococcus elongatus. Probable transmembrane protein YP_001297027.1 N-terminal region weakly similar to response regulator receiver domain YP_001297028.1 Some similarities chromosome segregation ATPases COG1196 YP_001297029.1 Weakly similar to pfam04851, ResIII, Type III restriction enzyme, res subunit. This family represents the res subunit of type III restriction enzymes YP_001297030.1 Similar to virulence protein COG3943 YP_001297031.1 Similar to adenine specific DNA methylase Mod COG2189 YP_001297032.1 Similar to protein of unknown function of Helicobacter hepaticus YP_001297033.1 Similar to protein of unknown function of Helicobacter hepaticus YP_001297034.1 Some weak similarities with eukaryotic proteins ofunknown function YP_001297035.1 Similar to protein of unknown function of Bacteroides thetaiotaomicron YP_001297036.1 Similar to protein of unknown function of Bacteroides spp. YP_001297039.1 Some weak similarities with MoxR-like ATPases COG0714 YP_001297040.1 Similar to protein of unknown function (ORF14) of Staphylococcus phage K YP_001297042.1 Probable transmembrane protein YP_001297043.1 Similar to protein of unknown function of Flavobacterium psychrophilum YP_001297044.1 Similar to beta-lactamase class C and other penicillin binding proteins COG1680. Probably involved in peptidoglycan modification (by similarity) YP_001297045.1 Similar to protein of unknown function of Desulfotalea psychrophila YP_001297048.1 Similar to protein of unknown function of Shewanella YP_001297052.1 ABC transporter, permease (IM), o228-family, import of unknown substrat, TC 3.A.1.Y.Z YP_001297053.1 Similar to uncharacterized protein conserved in bacteria COG3876 YP_001297054.1 Similar to protein of unknown function of Streptococcus sp. and Lactococcus lactis YP_001297055.1 Similar to putative methyltransferases of the CFB phylum YP_001297056.1 Some similarities with TonB protein YP_001297057.1 Similar to organic radical activating enzymes COG0602 YP_001297061.1 Some similarities with Cyanophage P-SSM4 fiber protein YP_001297062.1 Contains tetratrico peptide repeat (TPR), a structural motif that mediates protein\u2013protein interactions and the assembly of multiprotein complexes YP_001297063.1 ABC transporter, binding protein (BP), MOI- family,phosphate import (putative), TC 3.A.1.7.1 YP_001297064.1 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). Forms a complexwith the accessory proteins exbB and exbD (by similarity) YP_001297065.1 Involved in the tonB-dependent energy-dependent transport of various receptor-bound substrates YP_001297066.1 Similar to protein of unknown function of the CFB phylum. Probable exported protein YP_001297067.1 Involved in the tonB-dependent energy-dependent transport of various receptor-bound substrates. Protects exbD from proteolytic degradation and functionally stabilizes tonB YP_001297068.1 Similar to predicted ATPase COG0433 YP_001297069.1 Tryptophan metabolism YP_001297070.1 Penicillins and cephalosporins biosynthesis YP_001297071.1 Catalyzes the formation of putrescine from agmatine. Putrescine biosynthesis from arginine; second (last) step and spermidine biosynthesis from arginine; second step. YP_001297072.1 Tryptophan metabolism YP_001297073.1 involved in the peptidyltransferase reaction during translation YP_001297075.1 NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain (By similarity) YP_001297076.1 NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain (By similarity) YP_001297077.1 NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain (By similarity) YP_001297078.1 NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain (By similarity) YP_001297079.1 NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain (By similarity) YP_001297080.1 NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain (By similarity) YP_001297081.1 NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain (By similarity) YP_001297082.1 NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (by similarity) YP_001297083.1 Probable NADH dehydrogenase I subunit YP_001297084.1 NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain (By similarity) YP_001297085.1 NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain (By similarity) YP_001297086.1 NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain (By similarity) YP_001297087.1 NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain (By similarity) YP_001297088.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_001297089.1 NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain (By similarity) YP_001297090.1 Similar to large extracellular alpha-helical protein COG2373 YP_001297091.1 Cell wall formation YP_001297092.1 catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde in the final enzymatic step of quinolinate biosynthesis YP_001297094.1 Similar to protein of unknown function of the CFB phylum YP_001297095.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001297096.1 Some weak similarities with proteins of unknown function of Bacteroides thetaiotaomicron YP_001297099.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001297100.1 Similar to uncharacterized protein conserved in bacteria COG2137 YP_001297101.1 Weakly similar to PPE-repeat protein of Cytophaga hutchinsonii YP_001297102.1 Can catalyze the hydrolysis of ATP in the presenceof single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP- dependent hybridization of homologous single-stranded DNAs. It interacts with lexA causing its activation and leading to its autocatalytic cleavage (by similarity) YP_001297103.1 Similar to 1-acyl-sn-glycerol-3-phosphate acyltransferase COG0204 YP_001297105.1 Tetrahydrobiopterin biosynthesis; second step YP_001297106.1 This sigma factor is responsible for the expression of enzymes involved in arginine catabolism. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein glnG(ntrC) (by similarity) YP_001297107.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001297108.1 Similar to predicted exporters of the RND superfamily COG1033 YP_001297109.1 Similar to tRNA-dihydrouridine synthase COG0042. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) YP_001297110.1 Similar to coenzyme F390 synthetase COG1541 YP_001297111.1 Some weak similarities with predicted choloylglycine hydrolase COG4927 YP_001297112.1 Similar to phytoene dehydrogenase and related proteins COG1233 YP_001297113.1 N-terminal region similar to predicted exporter COG4258 and C-terminal region similar to 1-acyl-sn- glycerol-3-phosphate acyltransferase COG0204 YP_001297114.1 N-terminal region similar to glycosyltransferases involved in cell wall biogenesis COG0463 and C-terminal region similar to uncharacterized protein conserved in bacteria COG3216. Probable transmembrane protein YP_001297115.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001297116.1 Similar to 3-hydroxymyristoyl/3-hydroxydecanoyl- (acyl carrier protein) dehydratases COG0764 YP_001297117.1 Similar to protein of unknown function of the CFB phylum YP_001297118.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001297119.1 Similar to outer membrane lipoprotein-sorting protein LolA COG2834 YP_001297120.1 Similar to predicted xylanase/chitin deacetylase COG0726. Probable transmembrane protein YP_001297121.1 Similar to 3-oxoacyl-(acyl-carrier-protein) synthase COG0304 YP_001297122.1 Fatty acid biosynthesis YP_001297123.1 Similar to protein of unknown function YP_001297124.1 Phosphopantetheine-binding domain protein YP_001297125.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001297126.1 Fatty acid biosynthesis YP_001297127.1 Similar to predicted thioesterase COG0824 YP_001297128.1 ABC transporter, permease (IM), DRA- or DRI- family, export of unknown substrat, TC 3.A.1.Y.Z YP_001297129.1 ABC transporter, ATP-binding protein (ABC), DRA- or DRI-family, export of unknown substrat, TC 3.A.1.Y.Z YP_001297130.1 Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. Recognizes the double-stranded sequence CCGG and cleaves afterC-1 (by similarity) YP_001297131.1 This methylase recognizes the double-stranded sequence CCGG, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HpaII endonuclease (by similarity) YP_001297132.1 Similar to protein of unknown function YP_001297133.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Dechloromonas aromatica RCB YP_001297134.1 Some similarities with DarC protein of Pseudomonasaurantiaca, an acyl carrier protein for alkylresorcinol biosynthesis YP_001297135.1 Some similarities with DarC protein of Pseudomonasaurantiaca, an acyl carrier protein for alkylresorcinol biosynthesis YP_001297136.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; this condensing enzyme differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001297137.1 Similar to dialkylrecorsinol condensing enzyme of Pseudomonas aurantiaca, involved in flexirubin-type pigment biosynthesis. Probable transmembrane protein YP_001297138.1 Similar to phytoene dehydrogenase and related proteins COG1233 YP_001297139.1 Similar to predicted acyltransferase COG4261 YP_001297140.1 Phosphopantetheine-binding domain protein YP_001297141.1 Fatty acid biosynthesis YP_001297142.1 Fatty acid biosynthesis pathway; first reduction step (by similarity) YP_001297143.1 Probable transmembrane protein YP_001297144.1 Histidine degradation; first step YP_001297145.1 Similar to dehydrogenases (flavoproteins) COG0644 and to 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase COG0654 YP_001297146.1 Similar to Mg-dependent DNase COG0084 YP_001297147.1 Similar to protein of unknown function YP_001297148.1 Similar L-asparaginase of the CFB phylum COG0252 YP_001297149.1 Similar to tetracycline resistance element mobilization regulatory protein RteC of the CFB phylum YP_001297150.1 Similar to protein of unknown function of Bacteroides spp. YP_001297151.1 Some similarities with protein of unknown functionof Cytophaga hutchinsonii YP_001297152.1 Similar to predicted ATPase of Cytophaga hutchinsonii YP_001297153.1 Probable exported protein YP_001297154.1 Probable transmembrane protein YP_001297155.1 Some similarities with type II secretory pathway, component PulD COG1450 YP_001297156.1 Similar to type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB COG2804 YP_001297157.1 Probable transmembrane protein YP_001297158.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001297159.1 Probable OmpH-like outer membrane protein. Some similarities with P18 protein of Flavobacterium psychrophilum YP_001297160.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001297161.1 Some similarities with protein of unknown functionof Cytophaga hutchinsonii. Probable transmembrane potein YP_001297162.1 Contains tetratrico peptide repeat (TPR), a structural motif that mediates protein\u2013protein interactions and the assembly of multiprotein complexes YP_001297163.1 Some similarities with proteins of unknown function of Cytophaga hutchinsonii. Probable seceted protein YP_001297164.1 Some similarities with Rhs family protein YP_001297165.1 Some similarities with uncharacterized protein conserved in bacteria COG3236 and to YbiA of Escherichia coli YP_001297166.1 Some weak similarities with proteins of unknown function of the CFB phylum. Putative exported protein YP_001297167.1 Putative lipoprotein YP_001297168.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Probable transmembrane protein YP_001297169.1 Similar to protein of unknown function of Cytophaga hutchinsonii. Probable exported protein YP_001297170.1 Probable exported protein similar to protein of unknown function of Cytophaga hutchinsonii YP_001297171.1 Probable exported protein YP_001297172.1 Probable transmembrane protein YP_001297173.1 Similar to type II secretory pathway, component PulF COG1459 YP_001297174.1 Similar to protein of unknown function of Flavobacterium psychrophilum YP_001297175.1 Similar to hypothetical protein of Flavobacterium psychrophilum YP_001297177.1 Some weak similarities with protein of unknown function of Cytophaga hutchinsonii YP_001297178.1 Highly similar to protein of unknown function of Flavobacterium psychrophilum and some similarities with proteins of unknown function of Desulfotalea psychrophila andPhotobacterium profundum YP_001297179.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001297180.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001297181.1 Lysine metabolism YP_001297182.1 Thiamine metabolism YP_001297183.1 Fatty acid biosynthesis YP_001297184.1 Biotin metabolism YP_001297185.1 Cofactor biosynthesis; biotin biosynthesis; biotinfrom 6-carboxyhexanoyl-CoA: step 3 YP_001297186.1 Lipid A biosynthesis; fifth step YP_001297187.1 Probable transmembrane protein YP_001297188.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_001297189.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be involved in protection of the bacterium from thermal and osmotic stresses (By similarity) YP_001297190.1 Some similarities with competence protein and withpredicted membrane metal-binding protein COG0658. Probable transmembrane protein YP_001297191.1 Thioredoxins are small disulphide-containing redoxproteins that serves as a general protein disulphide oxidoreductase YP_001297192.1 Thioredoxins are small disulphide-containing redoxproteins that serves as a general protein disulphide oxidoreductase YP_001297193.1 Proton-dependent Oligopeptide Transporter (POT) family protein. TC 2.A.17.1.1 YP_001297194.1 Proton-dependent Oligopeptide Transporter (POT) family protein. TC 2.A.17.1.1 YP_001297195.1 Similar to dipeptidyl peptidase IV of Flavobacterium meningosepticum. Belongs to peptidase family S15 YP_001297197.1 Converts HMG-CoA to mevalonate (by similarity) YP_001297198.1 Weakly similar to mevalonate kinase COG1577 YP_001297201.1 The enzyme shows specific recognition of a C- terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala- Ala-|-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala (by similarity) YP_001297202.1 Similar to lactoylglutathione lyase and related lyases COG0346 YP_001297203.1 Cell wall formation. Peptidoglycan biosynthesis; final stages (by similarity) YP_001297204.1 Similar to glycine/D-amino acid oxidases (deaminating) COG0665 YP_001297205.1 Similar to Porphyromonas gingivalis sensor histidine kinase YP_001297206.1 Similar to conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family COG1853 YP_001297207.1 Similar to protein of unknown function of the CFB phylum YP_001297208.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_001297209.1 Similar to protein of unknown function. Probable transmembrane protein YP_001297210.1 Hydrolysis of the deoxyribose N-glycosidic bond toexcise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions (by similarity) YP_001297211.1 Some similarities with thiol-disulfide isomerase and thioredoxins COG0526 YP_001297213.1 Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (by similarity) YP_001297214.1 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (by similarity) YP_001297215.1 Similar to Fjo13 protein of Flavobacterium johnsoniae YP_001297216.1 Similar to FtsX protein of Flavobacterium johnsoniae involved in gliding motility and cell division YP_001297217.1 Probable transmembrane protein YP_001297218.1 Probable transmembrane protein YP_001297219.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001297220.1 Similar to predicted Zn-dependent protease COG2738. Probable transmembrane protein YP_001297221.1 Some similarities with ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases COG2146 YP_001297222.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001297223.1 Similar to diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases COG0537 YP_001297224.1 Similar to prolyl oligopeptidase of Flavobacteriumcolumnare YP_001297225.1 Aminopeptidase C inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred (by similarity) YP_001297226.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001297227.1 Lipid A biosynthesis; fourth step YP_001297229.1 Similar to saccharopine dehydrogenase and related protein COG1748. Lysine metabolism YP_001297230.1 Similar to uncharacterized small membrane protein COG2363 YP_001297231.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_001297232.1 Endonucleolytic cleavage of RNA, removing 5'- extranucleotides from tRNA precursor (by similarity) YP_001297233.1 Long-chain fatty acid biosynthesis; first step YP_001297234.1 Long-chain fatty acid biosynthesis; first step. This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA (By similarity) YP_001297235.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001297236.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001297237.1 Similar to protein of unknown function of the CFB phylum. Weakly similar to predicted metal-binding, possibly nucleic acid-binding protein COG1399 YP_001297238.1 De novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate. Catalyzes the NAD-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo- 4-(phosphohydroxy)butyric acid which spontaneously decarboxylate to form 1-amino-3-(phosphohydroxy)propan-2- one (3-amino-2-oxopropyl phosphate) (by similarity) YP_001297239.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001297240.1 Similar to protein of unknown function of the CFB phylum YP_001297241.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001297242.1 Similar to predicted metal-sulfur cluster biosynthetic enzyme COG2151 YP_001297243.1 Biosynthesis of Fe-S cluster; first step. Participates in cysteine desulfuration mediated by sufS YP_001297245.1 Biosynthesis of Fe-S cluster; first step YP_001297246.1 Similar to beta-lactamase class C and other penicillin binding proteins COG1680. Probably involved in peptidoglycan modification (by similarity) YP_001297247.1 Sulfur transfer pathway for Fe-S cluster assembly YP_001297248.1 Sulfur transfer pathway for Fe-S cluster assembly YP_001297249.1 with SufCD activates cysteine desulfurase SufS YP_001297250.1 Sulfur transfer pathway for Fe-S cluster assembly YP_001297251.1 Similar to Zn-dependent hydrolases, including glyoxylases COG0491 YP_001297252.1 Some similarities with subtilisin-like serine proteases COG1404. Probable exported protein YP_001297253.1 Some similarities with aminopeptidase N COG0308 YP_001297255.1 Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Although the function of this ferredoxin is unknown it is probable that it has a role as a cellular electron transfer protein. Involved in the in vivo assembly of the Fe-S clustersin a wide variety of iron-sulfur proteins (by similarity) YP_001297256.1 Resistance-Nodulation-Cell Division (RND) Superfamily. Probable transmembrane protein. TC 2.A.6.2.Z YP_001297257.1 Membrane Fusion Protein (MFP) Family. Probable lipoprotein. TC =8.A.1.Y.Z YP_001297258.1 Outer Membrane Factor (OMF) Family. TC 1.B.17.Y.Z YP_001297259.1 Similar to transcriptional regulator COG1309 YP_001297260.1 Similar to geranylgeranyl pyrophosphate synthase COG0142 YP_001297263.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001297264.1 The 2-oxoglutarate dehydrogenase complex catalyzesthe overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase(E3). Tricarboxylic acid cycle (by similarity) YP_001297265.1 Probable Drug:H+ Antiporter-1 (12 Spanner) (DHA1) Family Protein. TC : 2.A.1.2.Z YP_001297266.1 Similar to immunogenic 75 kDa protein PG4 of Porphyromonas gingivalis YP_001297267.1 Similar to protein of unknown function of Cytophaga hutchinsonii and Porphyromonas gingivalis YP_001297268.1 Probable exported protein YP_001297269.1 GTPase of unknown physiological role (by similarity) YP_001297270.1 ABC transporter, permease (IM), o228-family, import of unknown substrat, TC 3.A.1.Y.Z YP_001297271.1 involved in de novo purine biosynthesis YP_001297272.1 functions in MreBCD complex in some organisms YP_001297273.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001297274.1 Similar to protein of unknown function of the CFB phylum. Probable transmembrane protein YP_001297277.1 Similar to DNA/RNA endonuclease G, NUC1 COG1864 YP_001297278.1 High lysine content protein YP_001297279.1 Some weak similarities with proteins of unknown function YP_001297280.1 Similar to putative membrane-associated lipoprotein of Ornithobacterium rhinotracheale YP_001297281.1 Some similarities with protein of unknown function. Putative exported protein YP_001297282.1 Similar to predicted amidophosphoribosyltransferases COG1040 YP_001297283.1 Probable exported protein similar to protein of unknown function of Porphyromonas gingivalis and Bacteroidesfragilis YP_001297284.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001297285.1 Some similarities with PpiC-type peptidyl-prolyl cis-trans isomerase YP_001297286.1 Probable transmembrane protein YP_001297287.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001297288.1 Similar to protein of unknown function of the CFB phylum YP_001297289.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_001297291.1 Predicted Rossmann-fold nucleotide-binding proteininvolved in DNA uptake YP_001297292.1 Some similarities with protein of unknown functionof the CFB phylum YP_001297293.1 Similar to acyl-CoA hydrolase COG1607 YP_001297294.1 Similar to putative peptidase of the CFB phylum YP_001297295.1 Similar to protein of unknown function of Cytophaga hutchinsonii YP_001297296.1 Contains tetratrico peptide repeat (TPR), a structural motif that mediates protein\u2013protein interactions and the assembly of multiprotein complexes YP_001297300.1 Similar to YoeB protein of E. coli. Part of the toxin-antitoxin system yoeB/yefM. When overproduced in wild-type cells, inhibits bacterial growth and translation by cleavage of mRNA molecules while it has a weak effect on colony forming ability. Overproduction of Lon protease specifically activates yoeB-dependent mRNA cleavage (by similarity) YP_001297301.1 Similar to protein of unknown function of Agrobacterium tumefaciens, Fusobacterium nucleatum and Francisellanovicida YP_001297302.1 Probable transmembrane protein YP_001297304.1 catalyzes the formation of dUMP from dUTP YP_001297305.1 Similar to membrane protein involved in the exportof O-antigen and teichoic acid COG2244 YP_001297306.1 Similar to uncharacterized iron-regulated membraneprotein COG3182 YP_001297307.1 Probable major facilitator superfamily (MFS) permease. TC 2.A.1.Y.Z YP_001297308.1 Probably involved in siderophore biosynthesis YP_001297309.1 Similar to D-alanine-D-alanine ligase and related ATP-grasp enzyme COG1181 YP_001297310.1 Outer Membrane Receptor (OMR) Family protein.TC 1.B.14.Y.Z YP_001297311.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma subunit is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (by similarity) YP_001297312.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001297313.1 This protein seems to be part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) into CF(1) or is implicated in proton conduction (by similarity) YP_001297314.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_001297315.1 This is one of the three subunit of the nonenzymatic component (CF(0) subunit) of the ATPase complex (by similarity) YP_001297316.1 Key component of the proton channel; it may play adirect role in the translocation of protons across the membrane (by similarity) YP_001297317.1 Similar to alpha-tubulin suppressor and related RCC1 domain-containing proteins COG5184 YP_001297318.1 Probable transmembrane protein YP_001297319.1 Probable transmembrane protein YP_001297320.1 Similar integral membrane protein CcmA involved incell shape determination COG1664 YP_001297321.1 Contains tetratrico peptide repeat (TPR), a structural motif that mediates protein\u2013protein interactions and the assembly of multiprotein complexes YP_001297322.1 May be part of a multicomponent oxygenase involvedin phenylacetyl-CoA hydroxylation (by similarity) YP_001297323.1 Similar to ADP-heptose:LPS heptosyltransferase COG0859 YP_001297324.1 Similar to protein of unknown function of Leptospira interrogans YP_001297325.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001297326.1 Probable transmembrane protein YP_001297327.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001297329.1 Similar to glycosyltransferases COG0463 COG1215 COG1216 and to putative teichuronic acid biosynthesis glycosyl transferase TuaG of B. subtilis YP_001297330.1 Similar to putative colanic biosynthesis UDP- glucose lipid carrier transferase WcaJ of Escherichia coli YP_001297332.1 Lipopolysaccharide O-antigen biosynthesis; dTDP-L- rhamnose biosynthesis; fourth and last step YP_001297333.1 Lipopolysaccharide O-antigen biosynthesis; dTDP-L- rhamnose biosynthesis; third step YP_001297334.1 Similar to protein of unknown function of Desulfotalea psychrophila YP_001297335.1 Some similarities with putative outer membrane protein YP_001297336.1 Similar to protein of unknown function of the CFB phylum YP_001297337.1 Some similarities with putative membrane peptidaseof Bacteroides spp. YP_001297338.1 Weakly similar to twin-arginine translocation protein TatA/E YP_001297339.1 Similar to transcriptional accessory protein COG2183 YP_001297340.1 Co/Zn/Cd efflux system component. TC 2.A.4.1.Z YP_001297341.1 Probable transmembrane protein YP_001297342.1 Carbohydrate degradation; pentose phosphate pathway YP_001297343.1 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs (by similarity) YP_001297345.1 Similar to protein of unknown function of Chlorobium phaeobacteroides BS1 and Clostridium perfringen. Putative threonine efflux protein YP_001297347.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001297348.1 Probable exported protein YP_001297349.1 Probable transmembrane protein YP_001297351.1 Similar to membrane protease subunits, stomatin/prohibitin homologs COG0330 YP_001297352.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation