-- dump date 20140619_095742 -- class Genbank::misc_feature -- table misc_feature_note -- id note 573569000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 573569000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 573569000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573569000004 Walker A motif; other site 573569000005 ATP binding site [chemical binding]; other site 573569000006 Walker B motif; other site 573569000007 arginine finger; other site 573569000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 573569000009 DnaA box-binding interface [nucleotide binding]; other site 573569000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 573569000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 573569000012 putative DNA binding surface [nucleotide binding]; other site 573569000013 dimer interface [polypeptide binding]; other site 573569000014 beta-clamp/clamp loader binding surface; other site 573569000015 beta-clamp/translesion DNA polymerase binding surface; other site 573569000016 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573569000017 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 573569000018 EamA-like transporter family; Region: EamA; pfam00892 573569000019 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 573569000020 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573569000021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573569000022 ATP binding site [chemical binding]; other site 573569000023 Mg2+ binding site [ion binding]; other site 573569000024 G-X-G motif; other site 573569000025 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 573569000026 active site 573569000027 catalytic site [active] 573569000028 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573569000029 MULE transposase domain; Region: MULE; pfam10551 573569000030 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 573569000031 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573569000032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573569000033 active site 573569000034 phosphorylation site [posttranslational modification] 573569000035 intermolecular recognition site; other site 573569000036 dimerization interface [polypeptide binding]; other site 573569000037 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573569000038 DNA binding site [nucleotide binding] 573569000039 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 573569000040 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 573569000041 active site 573569000042 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 573569000043 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 573569000044 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 573569000045 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573569000046 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573569000047 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 573569000048 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573569000049 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 573569000050 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 573569000051 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573569000052 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573569000053 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 573569000054 substrate binding site [chemical binding]; other site 573569000055 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 573569000056 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 573569000057 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 573569000058 catalytic site [active] 573569000059 subunit interface [polypeptide binding]; other site 573569000060 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 573569000061 catalytic core [active] 573569000062 thiopurine S-methyltransferase; Reviewed; Region: PRK13256 573569000063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573569000064 S-adenosylmethionine binding site [chemical binding]; other site 573569000065 dihydroorotase; Reviewed; Region: PRK09236 573569000066 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573569000067 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 573569000068 active site 573569000069 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573569000070 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 573569000071 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 573569000072 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573569000073 HlyD family secretion protein; Region: HlyD_3; pfam13437 573569000074 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 573569000075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573569000076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573569000077 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573569000078 dimerization interface [polypeptide binding]; other site 573569000079 SOUL heme-binding protein; Region: SOUL; pfam04832 573569000080 Chorismate mutase type II; Region: CM_2; cl00693 573569000081 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 573569000082 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 573569000083 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573569000084 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 573569000085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 573569000086 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 573569000087 active site 573569000088 dimer interface [polypeptide binding]; other site 573569000089 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573569000090 phosphate binding site [ion binding]; other site 573569000091 prephenate dehydrogenase; Validated; Region: PRK08507 573569000092 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 573569000093 putative active site [active] 573569000094 dimerization interface [polypeptide binding]; other site 573569000095 putative tRNAtyr binding site [nucleotide binding]; other site 573569000096 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 573569000097 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 573569000098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569000099 putative substrate translocation pore; other site 573569000100 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 573569000101 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 573569000102 substrate binding [chemical binding]; other site 573569000103 active site 573569000104 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 573569000105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569000106 putative substrate translocation pore; other site 573569000107 POT family; Region: PTR2; cl17359 573569000108 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 573569000109 tartrate dehydrogenase; Region: TTC; TIGR02089 573569000110 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 573569000111 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 573569000112 substrate binding site [chemical binding]; other site 573569000113 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 573569000114 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 573569000115 substrate binding site [chemical binding]; other site 573569000116 ligand binding site [chemical binding]; other site 573569000117 2-isopropylmalate synthase; Validated; Region: PRK00915 573569000118 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 573569000119 active site 573569000120 catalytic residues [active] 573569000121 metal binding site [ion binding]; metal-binding site 573569000122 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 573569000123 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 573569000124 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 573569000125 homodimer interface [polypeptide binding]; other site 573569000126 substrate-cofactor binding pocket; other site 573569000127 catalytic residue [active] 573569000128 pyruvate phosphate dikinase; Provisional; Region: PRK09279 573569000129 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573569000130 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573569000131 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573569000132 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573569000133 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 573569000134 catalytic site [active] 573569000135 putative active site [active] 573569000136 putative substrate binding site [chemical binding]; other site 573569000137 dimer interface [polypeptide binding]; other site 573569000138 elongation factor P; Validated; Region: PRK00529 573569000139 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 573569000140 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 573569000141 RNA binding site [nucleotide binding]; other site 573569000142 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 573569000143 RNA binding site [nucleotide binding]; other site 573569000144 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 573569000145 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 573569000146 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 573569000147 putative acyl-acceptor binding pocket; other site 573569000148 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 573569000149 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 573569000150 putative acyl-acceptor binding pocket; other site 573569000151 membrane protein insertase; Provisional; Region: PRK01318 573569000152 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 573569000153 Haemolytic domain; Region: Haemolytic; cl00506 573569000154 Ribonuclease P; Region: Ribonuclease_P; pfam00825 573569000155 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 573569000156 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 573569000157 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 573569000158 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 573569000159 NAD(P) binding site [chemical binding]; other site 573569000160 shikimate binding site; other site 573569000161 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 573569000162 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573569000163 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573569000164 Predicted methyltransferases [General function prediction only]; Region: COG0313 573569000165 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 573569000166 putative SAM binding site [chemical binding]; other site 573569000167 putative homodimer interface [polypeptide binding]; other site 573569000168 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 573569000169 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 573569000170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573569000171 active site 573569000172 motif I; other site 573569000173 motif II; other site 573569000174 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 573569000175 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 573569000176 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 573569000177 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 573569000178 PLD-like domain; Region: PLDc_2; pfam13091 573569000179 putative homodimer interface [polypeptide binding]; other site 573569000180 putative active site [active] 573569000181 catalytic site [active] 573569000182 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573569000183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573569000184 ATP binding site [chemical binding]; other site 573569000185 putative Mg++ binding site [ion binding]; other site 573569000186 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 573569000187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573569000188 nucleotide binding region [chemical binding]; other site 573569000189 ATP-binding site [chemical binding]; other site 573569000190 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 573569000191 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573569000192 Ligand Binding Site [chemical binding]; other site 573569000193 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573569000194 Ligand Binding Site [chemical binding]; other site 573569000195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569000196 putative substrate translocation pore; other site 573569000197 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 573569000198 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 573569000199 LamB/YcsF family protein; Provisional; Region: PRK05406 573569000200 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 573569000201 putative metal dependent hydrolase; Provisional; Region: PRK11598 573569000202 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 573569000203 Sulfatase; Region: Sulfatase; pfam00884 573569000204 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 573569000205 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 573569000206 Phosphoesterase family; Region: Phosphoesterase; pfam04185 573569000207 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 573569000208 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 573569000209 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573569000210 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 573569000211 putative FMN binding site [chemical binding]; other site 573569000212 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 573569000213 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 573569000214 aromatic amino acid transport protein; Region: araaP; TIGR00837 573569000215 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 573569000216 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 573569000217 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 573569000218 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573569000219 catalytic residue [active] 573569000220 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 573569000221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573569000222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573569000223 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 573569000224 putative effector binding pocket; other site 573569000225 dimerization interface [polypeptide binding]; other site 573569000226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569000227 putative substrate translocation pore; other site 573569000228 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 573569000229 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 573569000230 dimer interface [polypeptide binding]; other site 573569000231 active site 573569000232 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 573569000233 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 573569000234 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 573569000235 GTP-binding protein LepA; Provisional; Region: PRK05433 573569000236 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 573569000237 G1 box; other site 573569000238 putative GEF interaction site [polypeptide binding]; other site 573569000239 GTP/Mg2+ binding site [chemical binding]; other site 573569000240 Switch I region; other site 573569000241 G2 box; other site 573569000242 G3 box; other site 573569000243 Switch II region; other site 573569000244 G4 box; other site 573569000245 G5 box; other site 573569000246 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 573569000247 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 573569000248 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 573569000249 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 573569000250 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 573569000251 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 573569000252 active site 573569000253 catalytic residues [active] 573569000254 metal binding site [ion binding]; metal-binding site 573569000255 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 573569000256 homopentamer interface [polypeptide binding]; other site 573569000257 active site 573569000258 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 573569000259 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 573569000260 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 573569000261 dimerization interface [polypeptide binding]; other site 573569000262 active site 573569000263 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 573569000264 Lumazine binding domain; Region: Lum_binding; pfam00677 573569000265 Lumazine binding domain; Region: Lum_binding; pfam00677 573569000266 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 573569000267 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 573569000268 catalytic motif [active] 573569000269 Zn binding site [ion binding]; other site 573569000270 RibD C-terminal domain; Region: RibD_C; pfam01872 573569000271 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 573569000272 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 573569000273 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 573569000274 dimer interface [polypeptide binding]; other site 573569000275 PYR/PP interface [polypeptide binding]; other site 573569000276 TPP binding site [chemical binding]; other site 573569000277 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573569000278 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 573569000279 TPP-binding site [chemical binding]; other site 573569000280 dimer interface [polypeptide binding]; other site 573569000281 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573569000282 dimer interface [polypeptide binding]; other site 573569000283 [2Fe-2S] cluster binding site [ion binding]; other site 573569000284 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 573569000285 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 573569000286 tandem repeat interface [polypeptide binding]; other site 573569000287 oligomer interface [polypeptide binding]; other site 573569000288 active site residues [active] 573569000289 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 573569000290 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 573569000291 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573569000292 preprotein translocase subunit SecB; Provisional; Region: PRK13031 573569000293 SecA binding site; other site 573569000294 Preprotein binding site; other site 573569000295 recombinase A; Provisional; Region: recA; PRK09354 573569000296 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 573569000297 hexamer interface [polypeptide binding]; other site 573569000298 Walker A motif; other site 573569000299 ATP binding site [chemical binding]; other site 573569000300 Walker B motif; other site 573569000301 recombination regulator RecX; Reviewed; Region: recX; PRK00117 573569000302 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573569000303 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573569000304 dimer interface [polypeptide binding]; other site 573569000305 ssDNA binding site [nucleotide binding]; other site 573569000306 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573569000307 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 573569000308 propionate/acetate kinase; Provisional; Region: PRK12379 573569000309 phosphate acetyltransferase; Reviewed; Region: PRK05632 573569000310 DRTGG domain; Region: DRTGG; pfam07085 573569000311 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 573569000312 succinic semialdehyde dehydrogenase; Region: PLN02278 573569000313 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 573569000314 tetramerization interface [polypeptide binding]; other site 573569000315 NAD(P) binding site [chemical binding]; other site 573569000316 catalytic residues [active] 573569000317 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 573569000318 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 573569000319 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573569000320 Coenzyme A binding pocket [chemical binding]; other site 573569000321 Predicted amidohydrolase [General function prediction only]; Region: COG0388 573569000322 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 573569000323 putative active site [active] 573569000324 catalytic triad [active] 573569000325 putative dimer interface [polypeptide binding]; other site 573569000326 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 573569000327 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 573569000328 dimer interface [polypeptide binding]; other site 573569000329 anticodon binding site; other site 573569000330 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 573569000331 homodimer interface [polypeptide binding]; other site 573569000332 motif 1; other site 573569000333 active site 573569000334 motif 2; other site 573569000335 GAD domain; Region: GAD; pfam02938 573569000336 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573569000337 active site 573569000338 motif 3; other site 573569000339 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 573569000340 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 573569000341 RNB domain; Region: RNB; pfam00773 573569000342 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 573569000343 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 573569000344 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 573569000345 domain interfaces; other site 573569000346 active site 573569000347 camphor resistance protein CrcB; Provisional; Region: PRK14226 573569000348 Zinc-finger domain; Region: zf-CHCC; cl01821 573569000349 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 573569000350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573569000351 dimer interface [polypeptide binding]; other site 573569000352 conserved gate region; other site 573569000353 putative PBP binding loops; other site 573569000354 ABC-ATPase subunit interface; other site 573569000355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573569000356 dimer interface [polypeptide binding]; other site 573569000357 conserved gate region; other site 573569000358 putative PBP binding loops; other site 573569000359 ABC-ATPase subunit interface; other site 573569000360 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 573569000361 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 573569000362 Walker A/P-loop; other site 573569000363 ATP binding site [chemical binding]; other site 573569000364 Q-loop/lid; other site 573569000365 ABC transporter signature motif; other site 573569000366 Walker B; other site 573569000367 D-loop; other site 573569000368 H-loop/switch region; other site 573569000369 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 573569000370 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 573569000371 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 573569000372 classical (c) SDRs; Region: SDR_c; cd05233 573569000373 NAD(P) binding site [chemical binding]; other site 573569000374 active site 573569000375 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 573569000376 Amidohydrolase; Region: Amidohydro_2; pfam04909 573569000377 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 573569000378 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 573569000379 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 573569000380 TrkA-N domain; Region: TrkA_N; pfam02254 573569000381 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 573569000382 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 573569000383 trimer interface [polypeptide binding]; other site 573569000384 putative metal binding site [ion binding]; other site 573569000385 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 573569000386 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 573569000387 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 573569000388 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 573569000389 putative active site [active] 573569000390 Zn binding site [ion binding]; other site 573569000391 YGGT family; Region: YGGT; pfam02325 573569000392 YGGT family; Region: YGGT; pfam02325 573569000393 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 573569000394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573569000395 ABC transporter signature motif; other site 573569000396 Walker B; other site 573569000397 D-loop; other site 573569000398 H-loop/switch region; other site 573569000399 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 573569000400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573569000401 dimer interface [polypeptide binding]; other site 573569000402 conserved gate region; other site 573569000403 putative PBP binding loops; other site 573569000404 ABC-ATPase subunit interface; other site 573569000405 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 573569000406 Competence protein; Region: Competence; pfam03772 573569000407 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573569000408 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 573569000409 putative acyl-acceptor binding pocket; other site 573569000410 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 573569000411 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 573569000412 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 573569000413 RNA binding site [nucleotide binding]; other site 573569000414 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 573569000415 RNA binding site [nucleotide binding]; other site 573569000416 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 573569000417 RNA binding site [nucleotide binding]; other site 573569000418 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573569000419 RNA binding site [nucleotide binding]; other site 573569000420 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573569000421 RNA binding site [nucleotide binding]; other site 573569000422 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 573569000423 RNA binding site [nucleotide binding]; other site 573569000424 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 573569000425 nucleoside/Zn binding site; other site 573569000426 dimer interface [polypeptide binding]; other site 573569000427 catalytic motif [active] 573569000428 D-alanyl-alanine synthetase A; Provisional; Region: PRK14569 573569000429 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 573569000430 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573569000431 Cell division protein FtsQ; Region: FtsQ; pfam03799 573569000432 cell division protein FtsA; Region: ftsA; TIGR01174 573569000433 Cell division protein FtsA; Region: FtsA; smart00842 573569000434 Cell division protein FtsA; Region: FtsA; pfam14450 573569000435 cell division protein FtsZ; Validated; Region: PRK09330 573569000436 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 573569000437 nucleotide binding site [chemical binding]; other site 573569000438 SulA interaction site; other site 573569000439 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 573569000440 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 573569000441 Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123 573569000442 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 573569000443 active site 573569000444 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 573569000445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573569000446 Walker A motif; other site 573569000447 ATP binding site [chemical binding]; other site 573569000448 Walker B motif; other site 573569000449 DNA polymerase III subunit delta'; Validated; Region: PRK08485 573569000450 arginine finger; other site 573569000451 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 573569000452 This domain is found in peptide chain release factors; Region: PCRF; smart00937 573569000453 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 573569000454 RF-1 domain; Region: RF-1; pfam00472 573569000455 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 573569000456 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 573569000457 dimer interface [polypeptide binding]; other site 573569000458 putative anticodon binding site; other site 573569000459 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 573569000460 motif 1; other site 573569000461 active site 573569000462 motif 2; other site 573569000463 motif 3; other site 573569000464 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 573569000465 Glutaminase; Region: Glutaminase; cl00907 573569000466 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 573569000467 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 573569000468 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 573569000469 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 573569000470 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 573569000471 glutamine synthetase; Region: PLN02284 573569000472 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 573569000473 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 573569000474 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 573569000475 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 573569000476 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 573569000477 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 573569000478 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 573569000479 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 573569000480 purine monophosphate binding site [chemical binding]; other site 573569000481 dimer interface [polypeptide binding]; other site 573569000482 putative catalytic residues [active] 573569000483 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 573569000484 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 573569000485 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 573569000486 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 573569000487 GDP-binding site [chemical binding]; other site 573569000488 ACT binding site; other site 573569000489 IMP binding site; other site 573569000490 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573569000491 active site 573569000492 Dienelactone hydrolase family; Region: DLH; pfam01738 573569000493 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 573569000494 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573569000495 ABC-ATPase subunit interface; other site 573569000496 dimer interface [polypeptide binding]; other site 573569000497 putative PBP binding regions; other site 573569000498 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573569000499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573569000500 Walker A/P-loop; other site 573569000501 ATP binding site [chemical binding]; other site 573569000502 Q-loop/lid; other site 573569000503 ABC transporter signature motif; other site 573569000504 Walker B; other site 573569000505 D-loop; other site 573569000506 H-loop/switch region; other site 573569000507 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573569000508 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 573569000509 intersubunit interface [polypeptide binding]; other site 573569000510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569000511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573569000512 putative substrate translocation pore; other site 573569000513 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573569000514 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573569000515 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 573569000516 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 573569000517 primosome assembly protein PriA; Validated; Region: PRK05580 573569000518 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573569000519 ATP binding site [chemical binding]; other site 573569000520 putative Mg++ binding site [ion binding]; other site 573569000521 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 573569000522 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573569000523 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573569000524 substrate binding pocket [chemical binding]; other site 573569000525 membrane-bound complex binding site; other site 573569000526 hinge residues; other site 573569000527 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 573569000528 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 573569000529 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 573569000530 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 573569000531 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 573569000532 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 573569000533 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 573569000534 trimer interface [polypeptide binding]; other site 573569000535 active site 573569000536 UDP-GlcNAc binding site [chemical binding]; other site 573569000537 lipid binding site [chemical binding]; lipid-binding site 573569000538 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 573569000539 pyridoxamine kinase; Validated; Region: PRK05756 573569000540 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 573569000541 dimer interface [polypeptide binding]; other site 573569000542 pyridoxal binding site [chemical binding]; other site 573569000543 ATP binding site [chemical binding]; other site 573569000544 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 573569000545 MoxR-like ATPases [General function prediction only]; Region: COG0714 573569000546 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 573569000547 Walker A motif; other site 573569000548 ATP binding site [chemical binding]; other site 573569000549 Walker B motif; other site 573569000550 arginine finger; other site 573569000551 Protein of unknown function DUF58; Region: DUF58; pfam01882 573569000552 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 573569000553 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 573569000554 metal ion-dependent adhesion site (MIDAS); other site 573569000555 von Willebrand factor type A domain; Region: VWA_2; pfam13519 573569000556 metal ion-dependent adhesion site (MIDAS); other site 573569000557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573569000558 TPR motif; other site 573569000559 binding surface 573569000560 TPR repeat; Region: TPR_11; pfam13414 573569000561 Oxygen tolerance; Region: BatD; pfam13584 573569000562 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 573569000563 putative substrate binding pocket [chemical binding]; other site 573569000564 AC domain interface; other site 573569000565 catalytic triad [active] 573569000566 AB domain interface; other site 573569000567 interchain disulfide; other site 573569000568 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 573569000569 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 573569000570 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573569000571 active site 573569000572 HIGH motif; other site 573569000573 nucleotide binding site [chemical binding]; other site 573569000574 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 573569000575 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 573569000576 active site 573569000577 KMSKS motif; other site 573569000578 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 573569000579 tRNA binding surface [nucleotide binding]; other site 573569000580 anticodon binding site; other site 573569000581 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 573569000582 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 573569000583 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 573569000584 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 573569000585 nudix motif; other site 573569000586 gamma-glutamyl kinase; Provisional; Region: PRK05429 573569000587 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 573569000588 nucleotide binding site [chemical binding]; other site 573569000589 homotetrameric interface [polypeptide binding]; other site 573569000590 putative phosphate binding site [ion binding]; other site 573569000591 putative allosteric binding site; other site 573569000592 PUA domain; Region: PUA; pfam01472 573569000593 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 573569000594 putative catalytic cysteine [active] 573569000595 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 573569000596 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573569000597 phosphate binding site [ion binding]; other site 573569000598 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 573569000599 dimer interface [polypeptide binding]; other site 573569000600 FMN binding site [chemical binding]; other site 573569000601 fumarate hydratase; Reviewed; Region: fumC; PRK00485 573569000602 Class II fumarases; Region: Fumarase_classII; cd01362 573569000603 active site 573569000604 tetramer interface [polypeptide binding]; other site 573569000605 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 573569000606 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 573569000607 HIGH motif; other site 573569000608 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 573569000609 active site 573569000610 KMSKS motif; other site 573569000611 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 573569000612 allantoate amidohydrolase; Reviewed; Region: PRK12890 573569000613 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 573569000614 active site 573569000615 metal binding site [ion binding]; metal-binding site 573569000616 dimer interface [polypeptide binding]; other site 573569000617 Predicted membrane protein [Function unknown]; Region: COG1288 573569000618 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 573569000619 serine O-acetyltransferase; Region: cysE; TIGR01172 573569000620 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 573569000621 trimer interface [polypeptide binding]; other site 573569000622 active site 573569000623 substrate binding site [chemical binding]; other site 573569000624 CoA binding site [chemical binding]; other site 573569000625 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 573569000626 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 573569000627 dimer interface [polypeptide binding]; other site 573569000628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569000629 catalytic residue [active] 573569000630 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 573569000631 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 573569000632 folate binding site [chemical binding]; other site 573569000633 NADP+ binding site [chemical binding]; other site 573569000634 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 573569000635 rRNA interaction site [nucleotide binding]; other site 573569000636 S8 interaction site; other site 573569000637 putative laminin-1 binding site; other site 573569000638 elongation factor Ts; Provisional; Region: tsf; PRK09377 573569000639 UBA/TS-N domain; Region: UBA; pfam00627 573569000640 Elongation factor TS; Region: EF_TS; pfam00889 573569000641 Elongation factor TS; Region: EF_TS; pfam00889 573569000642 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 573569000643 putative nucleotide binding site [chemical binding]; other site 573569000644 uridine monophosphate binding site [chemical binding]; other site 573569000645 homohexameric interface [polypeptide binding]; other site 573569000646 ribosome recycling factor; Reviewed; Region: frr; PRK00083 573569000647 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 573569000648 hinge region; other site 573569000649 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 573569000650 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 573569000651 catalytic residue [active] 573569000652 putative FPP diphosphate binding site; other site 573569000653 putative FPP binding hydrophobic cleft; other site 573569000654 dimer interface [polypeptide binding]; other site 573569000655 putative IPP diphosphate binding site; other site 573569000656 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 573569000657 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 573569000658 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 573569000659 trimer interface [polypeptide binding]; other site 573569000660 active site 573569000661 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 573569000662 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 573569000663 S17 interaction site [polypeptide binding]; other site 573569000664 S8 interaction site; other site 573569000665 16S rRNA interaction site [nucleotide binding]; other site 573569000666 streptomycin interaction site [chemical binding]; other site 573569000667 23S rRNA interaction site [nucleotide binding]; other site 573569000668 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 573569000669 30S ribosomal protein S7; Validated; Region: PRK05302 573569000670 elongation factor G; Reviewed; Region: PRK00007 573569000671 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 573569000672 G1 box; other site 573569000673 putative GEF interaction site [polypeptide binding]; other site 573569000674 GTP/Mg2+ binding site [chemical binding]; other site 573569000675 Switch I region; other site 573569000676 G2 box; other site 573569000677 G3 box; other site 573569000678 Switch II region; other site 573569000679 G4 box; other site 573569000680 G5 box; other site 573569000681 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 573569000682 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 573569000683 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 573569000684 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 573569000685 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 573569000686 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 573569000687 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 573569000688 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 573569000689 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 573569000690 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 573569000691 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 573569000692 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 573569000693 putative translocon binding site; other site 573569000694 protein-rRNA interface [nucleotide binding]; other site 573569000695 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 573569000696 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 573569000697 G-X-X-G motif; other site 573569000698 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 573569000699 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 573569000700 23S rRNA interface [nucleotide binding]; other site 573569000701 5S rRNA interface [nucleotide binding]; other site 573569000702 putative antibiotic binding site [chemical binding]; other site 573569000703 L25 interface [polypeptide binding]; other site 573569000704 L27 interface [polypeptide binding]; other site 573569000705 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 573569000706 23S rRNA interface [nucleotide binding]; other site 573569000707 putative translocon interaction site; other site 573569000708 signal recognition particle (SRP54) interaction site; other site 573569000709 L23 interface [polypeptide binding]; other site 573569000710 trigger factor interaction site; other site 573569000711 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 573569000712 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 573569000713 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 573569000714 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 573569000715 RNA binding site [nucleotide binding]; other site 573569000716 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 573569000717 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 573569000718 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 573569000719 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 573569000720 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 573569000721 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 573569000722 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 573569000723 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 573569000724 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 573569000725 23S rRNA interface [nucleotide binding]; other site 573569000726 L21e interface [polypeptide binding]; other site 573569000727 5S rRNA interface [nucleotide binding]; other site 573569000728 L27 interface [polypeptide binding]; other site 573569000729 L5 interface [polypeptide binding]; other site 573569000730 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 573569000731 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 573569000732 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 573569000733 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 573569000734 23S rRNA binding site [nucleotide binding]; other site 573569000735 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 573569000736 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 573569000737 SecY translocase; Region: SecY; pfam00344 573569000738 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 573569000739 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 573569000740 30S ribosomal protein S13; Region: bact_S13; TIGR03631 573569000741 30S ribosomal protein S11; Validated; Region: PRK05309 573569000742 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 573569000743 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 573569000744 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573569000745 RNA binding surface [nucleotide binding]; other site 573569000746 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 573569000747 alphaNTD homodimer interface [polypeptide binding]; other site 573569000748 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 573569000749 alphaNTD - beta interaction site [polypeptide binding]; other site 573569000750 alphaNTD - beta' interaction site [polypeptide binding]; other site 573569000751 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 573569000752 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 573569000753 Ion transport protein; Region: Ion_trans; pfam00520 573569000754 Ion channel; Region: Ion_trans_2; pfam07885 573569000755 heat shock protein 90; Provisional; Region: PRK05218 573569000756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573569000757 ATP binding site [chemical binding]; other site 573569000758 Mg2+ binding site [ion binding]; other site 573569000759 G-X-G motif; other site 573569000760 ornithine carbamoyltransferase; Provisional; Region: PRK00779 573569000761 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573569000762 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573569000763 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 573569000764 nucleotide binding site [chemical binding]; other site 573569000765 N-acetyl-L-glutamate binding site [chemical binding]; other site 573569000766 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 573569000767 heterotetramer interface [polypeptide binding]; other site 573569000768 active site pocket [active] 573569000769 cleavage site 573569000770 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 573569000771 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573569000772 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 573569000773 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573569000774 inhibitor-cofactor binding pocket; inhibition site 573569000775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569000776 catalytic residue [active] 573569000777 Arginine repressor [Transcription]; Region: ArgR; COG1438 573569000778 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 573569000779 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 573569000780 Lyase; Region: Lyase_1; pfam00206 573569000781 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 573569000782 tetramer interface [polypeptide binding]; other site 573569000783 argininosuccinate synthase; Provisional; Region: PRK13820 573569000784 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 573569000785 ANP binding site [chemical binding]; other site 573569000786 Substrate Binding Site II [chemical binding]; other site 573569000787 Substrate Binding Site I [chemical binding]; other site 573569000788 hypothetical protein; Provisional; Region: PRK11588 573569000789 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 573569000790 Chitin binding domain; Region: Chitin_bind_3; pfam03067 573569000791 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 573569000792 aromatic chitin/cellulose binding site residues [chemical binding]; other site 573569000793 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 573569000794 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 573569000795 aromatic chitin/cellulose binding site residues [chemical binding]; other site 573569000796 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 573569000797 aromatic chitin/cellulose binding site residues [chemical binding]; other site 573569000798 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573569000799 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573569000800 DNA binding residues [nucleotide binding] 573569000801 dimerization interface [polypeptide binding]; other site 573569000802 CTP synthetase; Validated; Region: pyrG; PRK05380 573569000803 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 573569000804 Catalytic site [active] 573569000805 active site 573569000806 UTP binding site [chemical binding]; other site 573569000807 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 573569000808 active site 573569000809 putative oxyanion hole; other site 573569000810 catalytic triad [active] 573569000811 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 573569000812 active site 573569000813 multimer interface [polypeptide binding]; other site 573569000814 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 573569000815 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 573569000816 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 573569000817 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 573569000818 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573569000819 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 573569000820 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 573569000821 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 573569000822 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 573569000823 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 573569000824 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 573569000825 FAD binding pocket [chemical binding]; other site 573569000826 FAD binding motif [chemical binding]; other site 573569000827 phosphate binding motif [ion binding]; other site 573569000828 beta-alpha-beta structure motif; other site 573569000829 NAD binding pocket [chemical binding]; other site 573569000830 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 573569000831 SnoaL-like domain; Region: SnoaL_2; pfam12680 573569000832 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 573569000833 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 573569000834 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573569000835 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573569000836 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573569000837 YCII-related domain; Region: YCII; cl00999 573569000838 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 573569000839 putative transporter; Provisional; Region: PRK11043 573569000840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569000841 putative substrate translocation pore; other site 573569000842 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 573569000843 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573569000844 active site 573569000845 DNA binding site [nucleotide binding] 573569000846 Int/Topo IB signature motif; other site 573569000847 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573569000848 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573569000849 non-specific DNA binding site [nucleotide binding]; other site 573569000850 salt bridge; other site 573569000851 sequence-specific DNA binding site [nucleotide binding]; other site 573569000852 AAA-like domain; Region: AAA_10; pfam12846 573569000853 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573569000854 Walker A motif; other site 573569000855 ATP binding site [chemical binding]; other site 573569000856 Walker B motif; other site 573569000857 Antirestriction protein (ArdA); Region: ArdA; pfam07275 573569000858 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 573569000859 HsdM N-terminal domain; Region: HsdM_N; pfam12161 573569000860 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 573569000861 Methyltransferase domain; Region: Methyltransf_26; pfam13659 573569000862 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 573569000863 Fic/DOC family; Region: Fic; pfam02661 573569000864 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 573569000865 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 573569000866 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 573569000867 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 573569000868 putative active site [active] 573569000869 Virulence protein [General function prediction only]; Region: COG3943 573569000870 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 573569000871 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 573569000872 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 573569000873 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573569000874 ATP binding site [chemical binding]; other site 573569000875 putative Mg++ binding site [ion binding]; other site 573569000876 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 573569000877 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 573569000878 Predicted flavoprotein [General function prediction only]; Region: COG0431 573569000879 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573569000880 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 573569000881 Low molecular weight phosphatase family; Region: LMWPc; cl00105 573569000882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573569000883 dimerization interface [polypeptide binding]; other site 573569000884 putative DNA binding site [nucleotide binding]; other site 573569000885 putative Zn2+ binding site [ion binding]; other site 573569000886 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 573569000887 arsenical-resistance protein; Region: acr3; TIGR00832 573569000888 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 573569000889 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 573569000890 Sulfate transporter family; Region: Sulfate_transp; pfam00916 573569000891 ProQ/FINO family; Region: ProQ; pfam04352 573569000892 Cation transport protein; Region: TrkH; cl17365 573569000893 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 573569000894 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 573569000895 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 573569000896 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 573569000897 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 573569000898 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 573569000899 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 573569000900 active site 573569000901 lysine transporter; Provisional; Region: PRK10836 573569000902 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 573569000903 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 573569000904 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 573569000905 putative active site [active] 573569000906 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 573569000907 Na binding site [ion binding]; other site 573569000908 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573569000909 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 573569000910 DXD motif; other site 573569000911 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 573569000912 Domain of unknown function DUF21; Region: DUF21; pfam01595 573569000913 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573569000914 Transporter associated domain; Region: CorC_HlyC; smart01091 573569000915 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 573569000916 aromatic chitin/cellulose binding site residues [chemical binding]; other site 573569000917 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 573569000918 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 573569000919 active site 573569000920 HIGH motif; other site 573569000921 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 573569000922 KMSKS motif; other site 573569000923 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 573569000924 tRNA binding surface [nucleotide binding]; other site 573569000925 anticodon binding site; other site 573569000926 HemK family putative methylases; Region: hemK_fam; TIGR00536 573569000927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569000928 S-adenosylmethionine binding site [chemical binding]; other site 573569000929 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 573569000930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569000931 putative substrate translocation pore; other site 573569000932 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 573569000933 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 573569000934 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573569000935 catalytic residue [active] 573569000936 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 573569000937 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 573569000938 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 573569000939 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 573569000940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569000941 S-adenosylmethionine binding site [chemical binding]; other site 573569000942 VacJ like lipoprotein; Region: VacJ; cl01073 573569000943 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 573569000944 BolA-like protein; Region: BolA; cl00386 573569000945 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573569000946 anti sigma factor interaction site; other site 573569000947 regulatory phosphorylation site [posttranslational modification]; other site 573569000948 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 573569000949 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 573569000950 mce related protein; Region: MCE; pfam02470 573569000951 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 573569000952 Permease; Region: Permease; pfam02405 573569000953 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 573569000954 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 573569000955 Walker A/P-loop; other site 573569000956 ATP binding site [chemical binding]; other site 573569000957 Q-loop/lid; other site 573569000958 ABC transporter signature motif; other site 573569000959 Walker B; other site 573569000960 D-loop; other site 573569000961 H-loop/switch region; other site 573569000962 cell division topological specificity factor MinE; Provisional; Region: PRK13990 573569000963 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 573569000964 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 573569000965 Switch I; other site 573569000966 Switch II; other site 573569000967 septum formation inhibitor; Reviewed; Region: minC; PRK04804 573569000968 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 573569000969 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 573569000970 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 573569000971 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 573569000972 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 573569000973 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 573569000974 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 573569000975 ssDNA binding site; other site 573569000976 generic binding surface II; other site 573569000977 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573569000978 ATP binding site [chemical binding]; other site 573569000979 putative Mg++ binding site [ion binding]; other site 573569000980 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573569000981 nucleotide binding region [chemical binding]; other site 573569000982 ATP-binding site [chemical binding]; other site 573569000983 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 573569000984 Fumarase C-terminus; Region: Fumerase_C; pfam05683 573569000985 Predicted acetyltransferase [General function prediction only]; Region: COG5628 573569000986 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 573569000987 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573569000988 putative metal binding site [ion binding]; other site 573569000989 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 573569000990 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 573569000991 nudix motif; other site 573569000992 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 573569000993 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 573569000994 ArsC family; Region: ArsC; pfam03960 573569000995 catalytic residue [active] 573569000996 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 573569000997 aspartate aminotransferase; Provisional; Region: PRK09275 573569000998 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 573569000999 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 573569001000 TrkA-C domain; Region: TrkA_C; pfam02080 573569001001 TrkA-C domain; Region: TrkA_C; pfam02080 573569001002 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 573569001003 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 573569001004 DNA protecting protein DprA; Region: dprA; TIGR00732 573569001005 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573569001006 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573569001007 ligand binding site [chemical binding]; other site 573569001008 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 573569001009 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573569001010 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 573569001011 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 573569001012 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 573569001013 homotrimer interaction site [polypeptide binding]; other site 573569001014 active site 573569001015 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 573569001016 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 573569001017 TolQ protein; Region: tolQ; TIGR02796 573569001018 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 573569001019 TolR protein; Region: tolR; TIGR02801 573569001020 TolA protein; Region: tolA_full; TIGR02794 573569001021 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 573569001022 TolB amino-terminal domain; Region: TolB_N; pfam04052 573569001023 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 573569001024 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573569001025 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573569001026 ligand binding site [chemical binding]; other site 573569001027 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 573569001028 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573569001029 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573569001030 FeS/SAM binding site; other site 573569001031 C factor cell-cell signaling protein; Provisional; Region: PRK09009 573569001032 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 573569001033 NADP binding site [chemical binding]; other site 573569001034 homodimer interface [polypeptide binding]; other site 573569001035 active site 573569001036 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 573569001037 DNA photolyase; Region: DNA_photolyase; pfam00875 573569001038 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 573569001039 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 573569001040 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 573569001041 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 573569001042 bile acid transporter; Region: bass; TIGR00841 573569001043 Sodium Bile acid symporter family; Region: SBF; cl17470 573569001044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 573569001045 YheO-like PAS domain; Region: PAS_6; pfam08348 573569001046 HTH domain; Region: HTH_22; pfam13309 573569001047 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573569001048 hypothetical protein; Provisional; Region: PRK10621 573569001049 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 573569001050 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 573569001051 Protein of unknown function, DUF393; Region: DUF393; pfam04134 573569001052 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 573569001053 UbiA prenyltransferase family; Region: UbiA; pfam01040 573569001054 Chorismate lyase; Region: Chor_lyase; cl01230 573569001055 ribonuclease PH; Reviewed; Region: rph; PRK00173 573569001056 Ribonuclease PH; Region: RNase_PH_bact; cd11362 573569001057 hexamer interface [polypeptide binding]; other site 573569001058 active site 573569001059 heat shock protein HtpX; Provisional; Region: PRK02870 573569001060 LemA family; Region: LemA; cl00742 573569001061 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 573569001062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573569001063 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 573569001064 putative dimerization interface [polypeptide binding]; other site 573569001065 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 573569001066 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 573569001067 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 573569001068 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 573569001069 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 573569001070 Colicin V production protein; Region: Colicin_V; pfam02674 573569001071 DNA repair protein RadA; Provisional; Region: PRK11823 573569001072 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 573569001073 Walker A motif/ATP binding site; other site 573569001074 ATP binding site [chemical binding]; other site 573569001075 Walker B motif; other site 573569001076 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 573569001077 PilZ domain; Region: PilZ; pfam07238 573569001078 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573569001079 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 573569001080 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 573569001081 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 573569001082 Tetramer interface [polypeptide binding]; other site 573569001083 active site 573569001084 FMN-binding site [chemical binding]; other site 573569001085 PQ loop repeat; Region: PQ-loop; cl17546 573569001086 PQ loop repeat; Region: PQ-loop; pfam04193 573569001087 methionine sulfoxide reductase B; Provisional; Region: PRK00222 573569001088 SelR domain; Region: SelR; pfam01641 573569001089 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 573569001090 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 573569001091 E-class dimer interface [polypeptide binding]; other site 573569001092 P-class dimer interface [polypeptide binding]; other site 573569001093 active site 573569001094 Cu2+ binding site [ion binding]; other site 573569001095 Zn2+ binding site [ion binding]; other site 573569001096 Cupin domain; Region: Cupin_2; cl17218 573569001097 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 573569001098 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 573569001099 substrate binding site [chemical binding]; other site 573569001100 catalytic Zn binding site [ion binding]; other site 573569001101 NAD binding site [chemical binding]; other site 573569001102 structural Zn binding site [ion binding]; other site 573569001103 dimer interface [polypeptide binding]; other site 573569001104 aspartate aminotransferase; Provisional; Region: PRK07568 573569001105 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573569001106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569001107 homodimer interface [polypeptide binding]; other site 573569001108 catalytic residue [active] 573569001109 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 573569001110 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 573569001111 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 573569001112 Walker A/P-loop; other site 573569001113 ATP binding site [chemical binding]; other site 573569001114 Q-loop/lid; other site 573569001115 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 573569001116 ABC transporter signature motif; other site 573569001117 Walker B; other site 573569001118 D-loop; other site 573569001119 H-loop/switch region; other site 573569001120 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 573569001121 Pilin (bacterial filament); Region: Pilin; pfam00114 573569001122 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 573569001123 Pilin (bacterial filament); Region: Pilin; pfam00114 573569001124 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 573569001125 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 573569001126 active site 573569001127 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 573569001128 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 573569001129 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 573569001130 homodimer interface [polypeptide binding]; other site 573569001131 NADP binding site [chemical binding]; other site 573569001132 substrate binding site [chemical binding]; other site 573569001133 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 573569001134 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 573569001135 dimerization interface [polypeptide binding]; other site 573569001136 putative ATP binding site [chemical binding]; other site 573569001137 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 573569001138 active site 573569001139 ATP binding site [chemical binding]; other site 573569001140 substrate binding site [chemical binding]; other site 573569001141 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 573569001142 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 573569001143 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573569001144 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 573569001145 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 573569001146 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 573569001147 active site 573569001148 substrate binding site [chemical binding]; other site 573569001149 cosubstrate binding site; other site 573569001150 catalytic site [active] 573569001151 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 573569001152 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 573569001153 ATP-grasp domain; Region: ATP-grasp; pfam02222 573569001154 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 573569001155 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 573569001156 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 573569001157 active site 573569001158 Zn binding site [ion binding]; other site 573569001159 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 573569001160 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 573569001161 O-Antigen ligase; Region: Wzy_C; pfam04932 573569001162 DNA topoisomerase I; Validated; Region: PRK06599 573569001163 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 573569001164 active site 573569001165 interdomain interaction site; other site 573569001166 putative metal-binding site [ion binding]; other site 573569001167 nucleotide binding site [chemical binding]; other site 573569001168 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 573569001169 domain I; other site 573569001170 DNA binding groove [nucleotide binding] 573569001171 phosphate binding site [ion binding]; other site 573569001172 domain II; other site 573569001173 domain III; other site 573569001174 nucleotide binding site [chemical binding]; other site 573569001175 catalytic site [active] 573569001176 domain IV; other site 573569001177 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 573569001178 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 573569001179 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 573569001180 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 573569001181 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573569001182 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573569001183 P-loop; other site 573569001184 Magnesium ion binding site [ion binding]; other site 573569001185 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 573569001186 ParB-like nuclease domain; Region: ParB; smart00470 573569001187 KorB domain; Region: KorB; pfam08535 573569001188 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 573569001189 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 573569001190 catalytic triad [active] 573569001191 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 573569001192 active site 573569001193 catalytic triad [active] 573569001194 oxyanion hole [active] 573569001195 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573569001196 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 573569001197 FtsJ-like methyltransferase; Region: FtsJ; cl17430 573569001198 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 573569001199 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 573569001200 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 573569001201 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573569001202 active site 573569001203 HIGH motif; other site 573569001204 nucleotide binding site [chemical binding]; other site 573569001205 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 573569001206 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 573569001207 active site 573569001208 KMSKS motif; other site 573569001209 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 573569001210 tRNA binding surface [nucleotide binding]; other site 573569001211 anticodon binding site; other site 573569001212 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 573569001213 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 573569001214 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 573569001215 active site 573569001216 Riboflavin kinase; Region: Flavokinase; pfam01687 573569001217 malate dehydrogenase; Provisional; Region: PRK13529 573569001218 Malic enzyme, N-terminal domain; Region: malic; pfam00390 573569001219 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 573569001220 NAD(P) binding pocket [chemical binding]; other site 573569001221 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 573569001222 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 573569001223 GTP-binding protein Der; Reviewed; Region: PRK00093 573569001224 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 573569001225 G1 box; other site 573569001226 GTP/Mg2+ binding site [chemical binding]; other site 573569001227 Switch I region; other site 573569001228 G2 box; other site 573569001229 Switch II region; other site 573569001230 G3 box; other site 573569001231 G4 box; other site 573569001232 G5 box; other site 573569001233 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 573569001234 G1 box; other site 573569001235 GTP/Mg2+ binding site [chemical binding]; other site 573569001236 Switch I region; other site 573569001237 G2 box; other site 573569001238 G3 box; other site 573569001239 Switch II region; other site 573569001240 G4 box; other site 573569001241 G5 box; other site 573569001242 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 573569001243 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 573569001244 putative active site [active] 573569001245 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 573569001246 FAD binding domain; Region: FAD_binding_4; pfam01565 573569001247 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 573569001248 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 573569001249 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573569001250 active site 573569001251 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 573569001252 nucleotide binding site/active site [active] 573569001253 HIT family signature motif; other site 573569001254 catalytic residue [active] 573569001255 ABC1 family; Region: ABC1; cl17513 573569001256 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 573569001257 SCP-2 sterol transfer family; Region: SCP2; pfam02036 573569001258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 573569001259 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 573569001260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569001261 S-adenosylmethionine binding site [chemical binding]; other site 573569001262 Glucokinase; Region: Glucokinase; pfam02685 573569001263 glucokinase, proteobacterial type; Region: glk; TIGR00749 573569001264 intracellular septation protein A; Reviewed; Region: PRK00259 573569001265 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 573569001266 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 573569001267 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 573569001268 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 573569001269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569001270 D-galactonate transporter; Region: 2A0114; TIGR00893 573569001271 putative substrate translocation pore; other site 573569001272 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 573569001273 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 573569001274 active site 573569001275 HIGH motif; other site 573569001276 KMSKS motif; other site 573569001277 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 573569001278 tRNA binding surface [nucleotide binding]; other site 573569001279 anticodon binding site; other site 573569001280 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 573569001281 dimer interface [polypeptide binding]; other site 573569001282 putative tRNA-binding site [nucleotide binding]; other site 573569001283 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 573569001284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569001285 putative substrate translocation pore; other site 573569001286 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 573569001287 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573569001288 Predicted transcriptional regulators [Transcription]; Region: COG1733 573569001289 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 573569001290 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 573569001291 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 573569001292 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573569001293 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573569001294 K+-transporting ATPase, c chain; Region: KdpC; cl00944 573569001295 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 573569001296 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 573569001297 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 573569001298 Ligand Binding Site [chemical binding]; other site 573569001299 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 573569001300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573569001301 dimer interface [polypeptide binding]; other site 573569001302 phosphorylation site [posttranslational modification] 573569001303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573569001304 ATP binding site [chemical binding]; other site 573569001305 Mg2+ binding site [ion binding]; other site 573569001306 G-X-G motif; other site 573569001307 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573569001308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573569001309 active site 573569001310 phosphorylation site [posttranslational modification] 573569001311 intermolecular recognition site; other site 573569001312 dimerization interface [polypeptide binding]; other site 573569001313 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573569001314 DNA binding site [nucleotide binding] 573569001315 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 573569001316 aromatic amino acid transport protein; Region: araaP; TIGR00837 573569001317 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 573569001318 GTP1/OBG; Region: GTP1_OBG; pfam01018 573569001319 Obg GTPase; Region: Obg; cd01898 573569001320 G1 box; other site 573569001321 GTP/Mg2+ binding site [chemical binding]; other site 573569001322 Switch I region; other site 573569001323 G2 box; other site 573569001324 G3 box; other site 573569001325 Switch II region; other site 573569001326 G4 box; other site 573569001327 G5 box; other site 573569001328 Amino acid permease; Region: AA_permease_2; pfam13520 573569001329 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 573569001330 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 573569001331 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 573569001332 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 573569001333 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 573569001334 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 573569001335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569001336 putative substrate translocation pore; other site 573569001337 putative protease; Provisional; Region: PRK15452 573569001338 Peptidase family U32; Region: Peptidase_U32; pfam01136 573569001339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569001340 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573569001341 putative substrate translocation pore; other site 573569001342 SnoaL-like domain; Region: SnoaL_2; pfam12680 573569001343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573569001344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573569001345 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 573569001346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573569001347 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 573569001348 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 573569001349 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573569001350 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573569001351 catalytic residue [active] 573569001352 amidophosphoribosyltransferase; Provisional; Region: PRK09246 573569001353 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 573569001354 active site 573569001355 tetramer interface [polypeptide binding]; other site 573569001356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573569001357 active site 573569001358 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 573569001359 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 573569001360 dimerization interface [polypeptide binding]; other site 573569001361 ATP binding site [chemical binding]; other site 573569001362 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 573569001363 dimerization interface [polypeptide binding]; other site 573569001364 ATP binding site [chemical binding]; other site 573569001365 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 573569001366 putative active site [active] 573569001367 catalytic triad [active] 573569001368 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 573569001369 active site 573569001370 catalytic residues [active] 573569001371 adenylosuccinate lyase; Provisional; Region: PRK07492 573569001372 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 573569001373 tetramer interface [polypeptide binding]; other site 573569001374 active site 573569001375 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 573569001376 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573569001377 E3 interaction surface; other site 573569001378 lipoyl attachment site [posttranslational modification]; other site 573569001379 HlyD family secretion protein; Region: HlyD_3; pfam13437 573569001380 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 573569001381 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 573569001382 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 573569001383 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 573569001384 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 573569001385 GatB domain; Region: GatB_Yqey; smart00845 573569001386 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 573569001387 active site 573569001388 oxyanion hole [active] 573569001389 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573569001390 catalytic triad [active] 573569001391 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 573569001392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569001393 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 573569001394 putative substrate translocation pore; other site 573569001395 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 573569001396 IucA / IucC family; Region: IucA_IucC; pfam04183 573569001397 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 573569001398 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 573569001399 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 573569001400 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 573569001401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573569001402 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 573569001403 IucA / IucC family; Region: IucA_IucC; pfam04183 573569001404 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 573569001405 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573569001406 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573569001407 catalytic residue [active] 573569001408 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 573569001409 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573569001410 inhibitor-cofactor binding pocket; inhibition site 573569001411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569001412 catalytic residue [active] 573569001413 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 573569001414 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 573569001415 nucleotide binding site [chemical binding]; other site 573569001416 substrate binding site [chemical binding]; other site 573569001417 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 573569001418 metal binding site 2 [ion binding]; metal-binding site 573569001419 putative DNA binding helix; other site 573569001420 metal binding site 1 [ion binding]; metal-binding site 573569001421 dimer interface [polypeptide binding]; other site 573569001422 structural Zn2+ binding site [ion binding]; other site 573569001423 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 573569001424 NADH dehydrogenase subunit B; Validated; Region: PRK06411 573569001425 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 573569001426 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 573569001427 NADH dehydrogenase subunit D; Validated; Region: PRK06075 573569001428 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 573569001429 NADH dehydrogenase subunit E; Validated; Region: PRK07539 573569001430 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 573569001431 putative dimer interface [polypeptide binding]; other site 573569001432 [2Fe-2S] cluster binding site [ion binding]; other site 573569001433 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 573569001434 SLBB domain; Region: SLBB; pfam10531 573569001435 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 573569001436 NADH dehydrogenase subunit G; Validated; Region: PRK09129 573569001437 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573569001438 catalytic loop [active] 573569001439 iron binding site [ion binding]; other site 573569001440 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 573569001441 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 573569001442 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 573569001443 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 573569001444 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 573569001445 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573569001446 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 573569001447 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 573569001448 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 573569001449 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 573569001450 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573569001451 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 573569001452 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573569001453 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 573569001454 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573569001455 Membrane fusogenic activity; Region: BMFP; pfam04380 573569001456 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 573569001457 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 573569001458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573569001459 Walker A motif; other site 573569001460 ATP binding site [chemical binding]; other site 573569001461 Walker B motif; other site 573569001462 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 573569001463 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 573569001464 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 573569001465 substrate binding site [chemical binding]; other site 573569001466 active site 573569001467 ribosome maturation protein RimP; Reviewed; Region: PRK00092 573569001468 hypothetical protein; Provisional; Region: PRK14641 573569001469 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 573569001470 putative oligomer interface [polypeptide binding]; other site 573569001471 putative RNA binding site [nucleotide binding]; other site 573569001472 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 573569001473 NusA N-terminal domain; Region: NusA_N; pfam08529 573569001474 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 573569001475 RNA binding site [nucleotide binding]; other site 573569001476 homodimer interface [polypeptide binding]; other site 573569001477 NusA-like KH domain; Region: KH_5; pfam13184 573569001478 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 573569001479 G-X-X-G motif; other site 573569001480 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 573569001481 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 573569001482 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 573569001483 translation initiation factor IF-2; Region: IF-2; TIGR00487 573569001484 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 573569001485 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 573569001486 G1 box; other site 573569001487 putative GEF interaction site [polypeptide binding]; other site 573569001488 GTP/Mg2+ binding site [chemical binding]; other site 573569001489 Switch I region; other site 573569001490 G2 box; other site 573569001491 G3 box; other site 573569001492 Switch II region; other site 573569001493 G4 box; other site 573569001494 G5 box; other site 573569001495 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 573569001496 Translation-initiation factor 2; Region: IF-2; pfam11987 573569001497 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 573569001498 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 573569001499 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 573569001500 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 573569001501 dimer interface [polypeptide binding]; other site 573569001502 motif 1; other site 573569001503 active site 573569001504 motif 2; other site 573569001505 motif 3; other site 573569001506 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 573569001507 anticodon binding site; other site 573569001508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569001509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573569001510 putative substrate translocation pore; other site 573569001511 Predicted ATPase [General function prediction only]; Region: COG1485 573569001512 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 573569001513 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573569001514 RNA binding surface [nucleotide binding]; other site 573569001515 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573569001516 active site 573569001517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569001518 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573569001519 putative substrate translocation pore; other site 573569001520 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 573569001521 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 573569001522 F0F1 ATP synthase subunit C; Provisional; Region: PRK13464 573569001523 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 573569001524 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 573569001525 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 573569001526 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 573569001527 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 573569001528 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573569001529 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 573569001530 beta subunit interaction interface [polypeptide binding]; other site 573569001531 Walker A motif; other site 573569001532 ATP binding site [chemical binding]; other site 573569001533 Walker B motif; other site 573569001534 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573569001535 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 573569001536 core domain interface [polypeptide binding]; other site 573569001537 delta subunit interface [polypeptide binding]; other site 573569001538 epsilon subunit interface [polypeptide binding]; other site 573569001539 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 573569001540 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573569001541 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 573569001542 alpha subunit interaction interface [polypeptide binding]; other site 573569001543 Walker A motif; other site 573569001544 ATP binding site [chemical binding]; other site 573569001545 Walker B motif; other site 573569001546 inhibitor binding site; inhibition site 573569001547 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573569001548 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 573569001549 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 573569001550 gamma subunit interface [polypeptide binding]; other site 573569001551 epsilon subunit interface [polypeptide binding]; other site 573569001552 LBP interface [polypeptide binding]; other site 573569001553 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 573569001554 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 573569001555 active site 573569001556 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 573569001557 putative GSH binding site [chemical binding]; other site 573569001558 catalytic residues [active] 573569001559 superoxide dismutase; Provisional; Region: PRK10543 573569001560 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 573569001561 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 573569001562 muropeptide transporter; Validated; Region: ampG; cl17669 573569001563 muropeptide transporter; Reviewed; Region: ampG; PRK11902 573569001564 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 573569001565 dimer interface [polypeptide binding]; other site 573569001566 Citrate synthase; Region: Citrate_synt; pfam00285 573569001567 active site 573569001568 citrylCoA binding site [chemical binding]; other site 573569001569 NADH binding [chemical binding]; other site 573569001570 cationic pore residues; other site 573569001571 oxalacetate/citrate binding site [chemical binding]; other site 573569001572 coenzyme A binding site [chemical binding]; other site 573569001573 catalytic triad [active] 573569001574 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 573569001575 Iron-sulfur protein interface; other site 573569001576 proximal quinone binding site [chemical binding]; other site 573569001577 SdhD (CybS) interface [polypeptide binding]; other site 573569001578 proximal heme binding site [chemical binding]; other site 573569001579 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 573569001580 SdhC subunit interface [polypeptide binding]; other site 573569001581 proximal heme binding site [chemical binding]; other site 573569001582 cardiolipin binding site; other site 573569001583 Iron-sulfur protein interface; other site 573569001584 proximal quinone binding site [chemical binding]; other site 573569001585 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 573569001586 L-aspartate oxidase; Provisional; Region: PRK06175 573569001587 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573569001588 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 573569001589 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 573569001590 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 573569001591 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 573569001592 TPP-binding site [chemical binding]; other site 573569001593 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 573569001594 PYR/PP interface [polypeptide binding]; other site 573569001595 dimer interface [polypeptide binding]; other site 573569001596 TPP binding site [chemical binding]; other site 573569001597 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573569001598 E3 interaction surface; other site 573569001599 lipoyl attachment site [posttranslational modification]; other site 573569001600 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 573569001601 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573569001602 E3 interaction surface; other site 573569001603 lipoyl attachment site [posttranslational modification]; other site 573569001604 e3 binding domain; Region: E3_binding; pfam02817 573569001605 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 573569001606 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573569001607 active site 573569001608 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 573569001609 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 573569001610 active site 573569001611 substrate binding site [chemical binding]; other site 573569001612 metal binding site [ion binding]; metal-binding site 573569001613 triosephosphate isomerase; Provisional; Region: PRK14567 573569001614 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 573569001615 substrate binding site [chemical binding]; other site 573569001616 dimer interface [polypeptide binding]; other site 573569001617 catalytic triad [active] 573569001618 Preprotein translocase SecG subunit; Region: SecG; pfam03840 573569001619 integrase; Provisional; Region: PRK09692 573569001620 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 573569001621 active site 573569001622 Int/Topo IB signature motif; other site 573569001623 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 573569001624 Toprim domain; Region: Toprim_3; pfam13362 573569001625 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 573569001626 spermidine hydroxycinnamoyl transferase; Provisional; Region: PLN03157 573569001627 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573569001628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573569001629 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 573569001630 HemN family oxidoreductase; Provisional; Region: PRK05660 573569001631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573569001632 FeS/SAM binding site; other site 573569001633 HemN C-terminal domain; Region: HemN_C; pfam06969 573569001634 GtrA-like protein; Region: GtrA; pfam04138 573569001635 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 573569001636 aconitate hydratase; Validated; Region: PRK09277 573569001637 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 573569001638 substrate binding site [chemical binding]; other site 573569001639 ligand binding site [chemical binding]; other site 573569001640 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 573569001641 substrate binding site [chemical binding]; other site 573569001642 AAA domain; Region: AAA_22; pfam13401 573569001643 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573569001644 Walker A motif; other site 573569001645 ATP binding site [chemical binding]; other site 573569001646 Walker B motif; other site 573569001647 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573569001648 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 573569001649 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 573569001650 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 573569001651 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 573569001652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573569001653 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 573569001654 NAD(P) binding site [chemical binding]; other site 573569001655 active site 573569001656 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573569001657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573569001658 dimer interface [polypeptide binding]; other site 573569001659 phosphorylation site [posttranslational modification] 573569001660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573569001661 ATP binding site [chemical binding]; other site 573569001662 Mg2+ binding site [ion binding]; other site 573569001663 G-X-G motif; other site 573569001664 Protein of unknown function (DUF523); Region: DUF523; pfam04463 573569001665 Uncharacterized conserved protein [Function unknown]; Region: COG3272 573569001666 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 573569001667 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 573569001668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569001669 putative substrate translocation pore; other site 573569001670 multidrug efflux protein; Reviewed; Region: PRK09579 573569001671 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573569001672 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573569001673 HlyD family secretion protein; Region: HlyD_3; pfam13437 573569001674 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 573569001675 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 573569001676 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 573569001677 active site 573569001678 NTP binding site [chemical binding]; other site 573569001679 metal binding triad [ion binding]; metal-binding site 573569001680 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 573569001681 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 573569001682 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573569001683 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 573569001684 Walker A/P-loop; other site 573569001685 ATP binding site [chemical binding]; other site 573569001686 Q-loop/lid; other site 573569001687 ABC transporter signature motif; other site 573569001688 Walker B; other site 573569001689 D-loop; other site 573569001690 H-loop/switch region; other site 573569001691 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 573569001692 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 573569001693 DNA polymerase I; Provisional; Region: PRK05755 573569001694 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 573569001695 active site 573569001696 metal binding site 1 [ion binding]; metal-binding site 573569001697 putative 5' ssDNA interaction site; other site 573569001698 metal binding site 3; metal-binding site 573569001699 metal binding site 2 [ion binding]; metal-binding site 573569001700 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 573569001701 putative DNA binding site [nucleotide binding]; other site 573569001702 putative metal binding site [ion binding]; other site 573569001703 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 573569001704 active site 573569001705 catalytic site [active] 573569001706 substrate binding site [chemical binding]; other site 573569001707 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 573569001708 active site 573569001709 DNA binding site [nucleotide binding] 573569001710 catalytic site [active] 573569001711 pantothenate kinase; Reviewed; Region: PRK13324 573569001712 phosphopentomutase; Provisional; Region: PRK05362 573569001713 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 573569001714 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 573569001715 intersubunit interface [polypeptide binding]; other site 573569001716 active site 573569001717 catalytic residue [active] 573569001718 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 573569001719 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 573569001720 Nucleoside recognition; Region: Gate; pfam07670 573569001721 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 573569001722 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 573569001723 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 573569001724 Nucleoside recognition; Region: Gate; pfam07670 573569001725 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 573569001726 thymidylate kinase; Validated; Region: tmk; PRK00698 573569001727 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 573569001728 TMP-binding site; other site 573569001729 ATP-binding site [chemical binding]; other site 573569001730 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 573569001731 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 573569001732 G1 box; other site 573569001733 putative GEF interaction site [polypeptide binding]; other site 573569001734 GTP/Mg2+ binding site [chemical binding]; other site 573569001735 Switch I region; other site 573569001736 G2 box; other site 573569001737 G3 box; other site 573569001738 Switch II region; other site 573569001739 G4 box; other site 573569001740 G5 box; other site 573569001741 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 573569001742 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573569001743 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 573569001744 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 573569001745 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 573569001746 P loop; other site 573569001747 GTP binding site [chemical binding]; other site 573569001748 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 573569001749 Part of AAA domain; Region: AAA_19; pfam13245 573569001750 Family description; Region: UvrD_C_2; pfam13538 573569001751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569001752 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573569001753 putative substrate translocation pore; other site 573569001754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569001755 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573569001756 putative substrate translocation pore; other site 573569001757 glycerol kinase; Provisional; Region: glpK; PRK00047 573569001758 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 573569001759 N- and C-terminal domain interface [polypeptide binding]; other site 573569001760 active site 573569001761 MgATP binding site [chemical binding]; other site 573569001762 catalytic site [active] 573569001763 metal binding site [ion binding]; metal-binding site 573569001764 glycerol binding site [chemical binding]; other site 573569001765 homotetramer interface [polypeptide binding]; other site 573569001766 homodimer interface [polypeptide binding]; other site 573569001767 FBP binding site [chemical binding]; other site 573569001768 protein IIAGlc interface [polypeptide binding]; other site 573569001769 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 573569001770 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 573569001771 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 573569001772 amphipathic channel; other site 573569001773 Asn-Pro-Ala signature motifs; other site 573569001774 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573569001775 AAA domain; Region: AAA_30; pfam13604 573569001776 Family description; Region: UvrD_C_2; pfam13538 573569001777 elongation factor Tu; Reviewed; Region: PRK00049 573569001778 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 573569001779 G1 box; other site 573569001780 GEF interaction site [polypeptide binding]; other site 573569001781 GTP/Mg2+ binding site [chemical binding]; other site 573569001782 Switch I region; other site 573569001783 G2 box; other site 573569001784 G3 box; other site 573569001785 Switch II region; other site 573569001786 G4 box; other site 573569001787 G5 box; other site 573569001788 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 573569001789 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 573569001790 Antibiotic Binding Site [chemical binding]; other site 573569001791 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 573569001792 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 573569001793 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 573569001794 putative homodimer interface [polypeptide binding]; other site 573569001795 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 573569001796 heterodimer interface [polypeptide binding]; other site 573569001797 homodimer interface [polypeptide binding]; other site 573569001798 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 573569001799 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 573569001800 23S rRNA interface [nucleotide binding]; other site 573569001801 L7/L12 interface [polypeptide binding]; other site 573569001802 putative thiostrepton binding site; other site 573569001803 L25 interface [polypeptide binding]; other site 573569001804 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 573569001805 mRNA/rRNA interface [nucleotide binding]; other site 573569001806 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 573569001807 23S rRNA interface [nucleotide binding]; other site 573569001808 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 573569001809 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 573569001810 core dimer interface [polypeptide binding]; other site 573569001811 peripheral dimer interface [polypeptide binding]; other site 573569001812 L10 interface [polypeptide binding]; other site 573569001813 L11 interface [polypeptide binding]; other site 573569001814 putative EF-Tu interaction site [polypeptide binding]; other site 573569001815 putative EF-G interaction site [polypeptide binding]; other site 573569001816 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 573569001817 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 573569001818 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 573569001819 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 573569001820 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 573569001821 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 573569001822 RPB3 interaction site [polypeptide binding]; other site 573569001823 RPB1 interaction site [polypeptide binding]; other site 573569001824 RPB11 interaction site [polypeptide binding]; other site 573569001825 RPB10 interaction site [polypeptide binding]; other site 573569001826 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 573569001827 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 573569001828 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 573569001829 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 573569001830 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 573569001831 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 573569001832 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 573569001833 cleft; other site 573569001834 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 573569001835 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 573569001836 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 573569001837 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 573569001838 DNA binding site [nucleotide binding] 573569001839 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 573569001840 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 573569001841 UGMP family protein; Validated; Region: PRK09604 573569001842 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 573569001843 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 573569001844 Di-iron ligands [ion binding]; other site 573569001845 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 573569001846 S-adenosylmethionine synthetase; Validated; Region: PRK05250 573569001847 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 573569001848 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 573569001849 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 573569001850 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 573569001851 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 573569001852 RimM N-terminal domain; Region: RimM; pfam01782 573569001853 PRC-barrel domain; Region: PRC; pfam05239 573569001854 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 573569001855 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 573569001856 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 573569001857 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573569001858 active site 573569001859 DNA binding site [nucleotide binding] 573569001860 Int/Topo IB signature motif; other site 573569001861 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 573569001862 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 573569001863 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 573569001864 Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476 573569001865 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 573569001866 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 573569001867 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573569001868 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 573569001869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573569001870 NAD(P) binding site [chemical binding]; other site 573569001871 active site 573569001872 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573569001873 AMP-binding enzyme; Region: AMP-binding; pfam00501 573569001874 acyl-activating enzyme (AAE) consensus motif; other site 573569001875 AMP binding site [chemical binding]; other site 573569001876 active site 573569001877 CoA binding site [chemical binding]; other site 573569001878 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573569001879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573569001880 NAD(P) binding site [chemical binding]; other site 573569001881 active site 573569001882 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 573569001883 putative active site [active] 573569001884 Ap4A binding site [chemical binding]; other site 573569001885 nudix motif; other site 573569001886 putative metal binding site [ion binding]; other site 573569001887 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 573569001888 active site 573569001889 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 573569001890 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 573569001891 amidase catalytic site [active] 573569001892 Zn binding residues [ion binding]; other site 573569001893 substrate binding site [chemical binding]; other site 573569001894 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 573569001895 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 573569001896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573569001897 Mg2+ binding site [ion binding]; other site 573569001898 G-X-G motif; other site 573569001899 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 573569001900 anchoring element; other site 573569001901 dimer interface [polypeptide binding]; other site 573569001902 ATP binding site [chemical binding]; other site 573569001903 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 573569001904 active site 573569001905 metal binding site [ion binding]; metal-binding site 573569001906 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 573569001907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569001908 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 573569001909 putative substrate translocation pore; other site 573569001910 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 573569001911 Trp docking motif [polypeptide binding]; other site 573569001912 PQQ-like domain; Region: PQQ_2; pfam13360 573569001913 PQQ-like domain; Region: PQQ_2; pfam13360 573569001914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 573569001915 glutamyl-tRNA reductase; Provisional; Region: PRK13940 573569001916 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 573569001917 tRNA; other site 573569001918 putative tRNA binding site [nucleotide binding]; other site 573569001919 putative NADP binding site [chemical binding]; other site 573569001920 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 573569001921 peptide chain release factor 1; Validated; Region: prfA; PRK00591 573569001922 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 573569001923 This domain is found in peptide chain release factors; Region: PCRF; smart00937 573569001924 RF-1 domain; Region: RF-1; pfam00472 573569001925 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 573569001926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569001927 S-adenosylmethionine binding site [chemical binding]; other site 573569001928 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 573569001929 hypothetical protein; Validated; Region: PRK02101 573569001930 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 573569001931 Predicted exporter [General function prediction only]; Region: COG4258 573569001932 Protein export membrane protein; Region: SecD_SecF; cl14618 573569001933 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 573569001934 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 573569001935 active site 573569001936 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 573569001937 putative acyl-acceptor binding pocket; other site 573569001938 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 573569001939 Ligand binding site; other site 573569001940 Putative Catalytic site; other site 573569001941 DXD motif; other site 573569001942 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 573569001943 active site 2 [active] 573569001944 active site 1 [active] 573569001945 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573569001946 acyl-activating enzyme (AAE) consensus motif; other site 573569001947 AMP binding site [chemical binding]; other site 573569001948 active site 573569001949 CoA binding site [chemical binding]; other site 573569001950 Predicted membrane protein [Function unknown]; Region: COG4648 573569001951 acyl carrier protein; Provisional; Region: PRK05350 573569001952 Phosphopantetheine attachment site; Region: PP-binding; cl09936 573569001953 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573569001954 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573569001955 putative acyl-acceptor binding pocket; other site 573569001956 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 573569001957 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 573569001958 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 573569001959 dimer interface [polypeptide binding]; other site 573569001960 active site 573569001961 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 573569001962 active site 2 [active] 573569001963 active site 1 [active] 573569001964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573569001965 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 573569001966 NAD(P) binding site [chemical binding]; other site 573569001967 active site 573569001968 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 573569001969 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 573569001970 dimer interface [polypeptide binding]; other site 573569001971 active site 573569001972 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 573569001973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573569001974 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 573569001975 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 573569001976 G1 box; other site 573569001977 GTP/Mg2+ binding site [chemical binding]; other site 573569001978 Switch I region; other site 573569001979 G2 box; other site 573569001980 G3 box; other site 573569001981 Switch II region; other site 573569001982 G4 box; other site 573569001983 G5 box; other site 573569001984 Nucleoside recognition; Region: Gate; pfam07670 573569001985 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 573569001986 Nucleoside recognition; Region: Gate; pfam07670 573569001987 FeoA domain; Region: FeoA; cl00838 573569001988 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 573569001989 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 573569001990 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573569001991 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 573569001992 oligomerisation interface [polypeptide binding]; other site 573569001993 mobile loop; other site 573569001994 roof hairpin; other site 573569001995 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 573569001996 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 573569001997 ring oligomerisation interface [polypeptide binding]; other site 573569001998 ATP/Mg binding site [chemical binding]; other site 573569001999 stacking interactions; other site 573569002000 hinge regions; other site 573569002001 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 573569002002 short chain dehydrogenase; Provisional; Region: PRK05993 573569002003 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 573569002004 NADP binding site [chemical binding]; other site 573569002005 active site 573569002006 steroid binding site; other site 573569002007 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 573569002008 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 573569002009 active site 573569002010 catalytic residues [active] 573569002011 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 573569002012 DNA-binding interface [nucleotide binding]; DNA binding site 573569002013 HI0933-like protein; Region: HI0933_like; pfam03486 573569002014 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 573569002015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569002016 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 573569002017 putative substrate translocation pore; other site 573569002018 glutamate dehydrogenase; Provisional; Region: PRK09414 573569002019 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 573569002020 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 573569002021 NAD(P) binding site [chemical binding]; other site 573569002022 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 573569002023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 573569002024 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 573569002025 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 573569002026 active site 573569002027 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573569002028 substrate binding site [chemical binding]; other site 573569002029 catalytic residues [active] 573569002030 dimer interface [polypeptide binding]; other site 573569002031 Amino acid permease; Region: AA_permease_2; pfam13520 573569002032 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 573569002033 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 573569002034 DNA binding site [nucleotide binding] 573569002035 active site 573569002036 Uncharacterized conserved protein [Function unknown]; Region: COG0398 573569002037 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 573569002038 mercuric reductase; Validated; Region: PRK06370 573569002039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573569002040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573569002041 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573569002042 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 573569002043 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 573569002044 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573569002045 HSP70 interaction site [polypeptide binding]; other site 573569002046 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 573569002047 substrate binding site [polypeptide binding]; other site 573569002048 dimer interface [polypeptide binding]; other site 573569002049 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573569002050 EamA-like transporter family; Region: EamA; pfam00892 573569002051 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 573569002052 aromatic chitin/cellulose binding site residues [chemical binding]; other site 573569002053 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 573569002054 aromatic chitin/cellulose binding site residues [chemical binding]; other site 573569002055 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 573569002056 putative sugar binding site [chemical binding]; other site 573569002057 catalytic residues [active] 573569002058 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 573569002059 aromatic amino acid transport protein; Region: araaP; TIGR00837 573569002060 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 573569002061 HD domain; Region: HD_4; pfam13328 573569002062 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 573569002063 synthetase active site [active] 573569002064 NTP binding site [chemical binding]; other site 573569002065 metal binding site [ion binding]; metal-binding site 573569002066 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 573569002067 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 573569002068 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 573569002069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569002070 S-adenosylmethionine binding site [chemical binding]; other site 573569002071 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 573569002072 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573569002073 active site 573569002074 DNA binding site [nucleotide binding] 573569002075 Int/Topo IB signature motif; other site 573569002076 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 573569002077 preprotein translocase subunit SecB; Validated; Region: PRK05751 573569002078 SecA binding site; other site 573569002079 Preprotein binding site; other site 573569002080 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 573569002081 MutS domain I; Region: MutS_I; pfam01624 573569002082 MutS domain II; Region: MutS_II; pfam05188 573569002083 MutS domain III; Region: MutS_III; pfam05192 573569002084 MutS domain V; Region: MutS_V; pfam00488 573569002085 Walker A/P-loop; other site 573569002086 ATP binding site [chemical binding]; other site 573569002087 Q-loop/lid; other site 573569002088 ABC transporter signature motif; other site 573569002089 Walker B; other site 573569002090 D-loop; other site 573569002091 H-loop/switch region; other site 573569002092 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 573569002093 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 573569002094 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 573569002095 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 573569002096 putative active site [active] 573569002097 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 573569002098 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 573569002099 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 573569002100 active site 573569002101 HIGH motif; other site 573569002102 dimer interface [polypeptide binding]; other site 573569002103 KMSKS motif; other site 573569002104 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 573569002105 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cd00598 573569002106 active site 573569002107 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 573569002108 dephospho-CoA kinase; Region: TIGR00152 573569002109 CoA-binding site [chemical binding]; other site 573569002110 ATP-binding [chemical binding]; other site 573569002111 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 573569002112 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 573569002113 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 573569002114 active site 573569002115 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 573569002116 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 573569002117 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 573569002118 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 573569002119 Enoylreductase; Region: PKS_ER; smart00829 573569002120 NAD(P) binding site [chemical binding]; other site 573569002121 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 573569002122 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 573569002123 NADP binding site [chemical binding]; other site 573569002124 active site 573569002125 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 573569002126 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 573569002127 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 573569002128 substrate-cofactor binding pocket; other site 573569002129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569002130 catalytic residue [active] 573569002131 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 573569002132 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 573569002133 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 573569002134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573569002135 NAD(P) binding site [chemical binding]; other site 573569002136 active site 573569002137 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 573569002138 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 573569002139 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 573569002140 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 573569002141 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 573569002142 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 573569002143 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 573569002144 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 573569002145 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 573569002146 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573569002147 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 573569002148 Walker A/P-loop; other site 573569002149 ATP binding site [chemical binding]; other site 573569002150 Q-loop/lid; other site 573569002151 ABC transporter signature motif; other site 573569002152 Walker B; other site 573569002153 D-loop; other site 573569002154 H-loop/switch region; other site 573569002155 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 573569002156 ABC-2 type transporter; Region: ABC2_membrane; cl17235 573569002157 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 573569002158 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 573569002159 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 573569002160 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 573569002161 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573569002162 active site 573569002163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573569002164 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573569002165 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 573569002166 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 573569002167 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 573569002168 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 573569002169 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 573569002170 potential frameshift: common BLAST hit: gi|167626593|ref|YP_001677093.1| transposase for IS1106 573569002171 Transposase domain (DUF772); Region: DUF772; pfam05598 573569002172 Transposase domain (DUF772); Region: DUF772; pfam05598 573569002173 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573569002174 DDE superfamily endonuclease; Region: DDE_4; cl17710 573569002175 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 573569002176 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573569002177 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573569002178 active site 573569002179 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 573569002180 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 573569002181 active site 573569002182 homodimer interface [polypeptide binding]; other site 573569002183 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 573569002184 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 573569002185 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 573569002186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 573569002187 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573569002188 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573569002189 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573569002190 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573569002191 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573569002192 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 573569002193 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 573569002194 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 573569002195 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 573569002196 putative ligand binding site [chemical binding]; other site 573569002197 Phosphotransferase enzyme family; Region: APH; pfam01636 573569002198 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573569002199 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573569002200 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 573569002201 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 573569002202 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 573569002203 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 573569002204 dimer interface [polypeptide binding]; other site 573569002205 TPP-binding site [chemical binding]; other site 573569002206 potential frameshift: common BLAST hit: gi|118498064|ref|YP_899114.1| dihydrolipoamide acetyltransferase 573569002207 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573569002208 E3 interaction surface; other site 573569002209 lipoyl attachment site [posttranslational modification]; other site 573569002210 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573569002211 E3 interaction surface; other site 573569002212 lipoyl attachment site [posttranslational modification]; other site 573569002213 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573569002214 E3 interaction surface; other site 573569002215 lipoyl attachment site [posttranslational modification]; other site 573569002216 e3 binding domain; Region: E3_binding; pfam02817 573569002217 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 573569002218 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 573569002219 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 573569002220 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573569002221 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 573569002222 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573569002223 NAD binding site [chemical binding]; other site 573569002224 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573569002225 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 573569002226 ligand binding site [chemical binding]; other site 573569002227 active site 573569002228 UGI interface [polypeptide binding]; other site 573569002229 catalytic site [active] 573569002230 Protein of unknown function (DUF461); Region: DUF461; pfam04314 573569002231 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 573569002232 aromatic chitin/cellulose binding site residues [chemical binding]; other site 573569002233 DNA gyrase subunit A; Validated; Region: PRK05560 573569002234 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 573569002235 CAP-like domain; other site 573569002236 active site 573569002237 primary dimer interface [polypeptide binding]; other site 573569002238 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573569002239 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573569002240 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573569002241 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573569002242 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573569002243 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573569002244 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 573569002245 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 573569002246 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 573569002247 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 573569002248 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 573569002249 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573569002250 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573569002251 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573569002252 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573569002253 Surface antigen; Region: Bac_surface_Ag; pfam01103 573569002254 periplasmic chaperone; Provisional; Region: PRK10780 573569002255 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 573569002256 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 573569002257 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 573569002258 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 573569002259 trimer interface [polypeptide binding]; other site 573569002260 active site 573569002261 UDP-GlcNAc binding site [chemical binding]; other site 573569002262 lipid binding site [chemical binding]; lipid-binding site 573569002263 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 573569002264 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 573569002265 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 573569002266 active site 573569002267 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 573569002268 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 573569002269 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 573569002270 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 573569002271 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 573569002272 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 573569002273 substrate binding pocket [chemical binding]; other site 573569002274 chain length determination region; other site 573569002275 substrate-Mg2+ binding site; other site 573569002276 catalytic residues [active] 573569002277 aspartate-rich region 1; other site 573569002278 active site lid residues [active] 573569002279 aspartate-rich region 2; other site 573569002280 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 573569002281 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 573569002282 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573569002283 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 573569002284 active site 573569002285 dimerization interface [polypeptide binding]; other site 573569002286 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 573569002287 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 573569002288 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573569002289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573569002290 active site 573569002291 phosphorylation site [posttranslational modification] 573569002292 intermolecular recognition site; other site 573569002293 dimerization interface [polypeptide binding]; other site 573569002294 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573569002295 DNA binding site [nucleotide binding] 573569002296 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 573569002297 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573569002298 Catalytic site [active] 573569002299 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573569002300 ribonuclease III; Reviewed; Region: rnc; PRK00102 573569002301 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 573569002302 dimerization interface [polypeptide binding]; other site 573569002303 active site 573569002304 metal binding site [ion binding]; metal-binding site 573569002305 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 573569002306 dsRNA binding site [nucleotide binding]; other site 573569002307 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 573569002308 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 573569002309 RNA binding site [nucleotide binding]; other site 573569002310 active site 573569002311 ribonuclease R; Region: RNase_R; TIGR02063 573569002312 RNB domain; Region: RNB; pfam00773 573569002313 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 573569002314 RNA binding site [nucleotide binding]; other site 573569002315 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 573569002316 Fatty acid desaturase; Region: FA_desaturase; pfam00487 573569002317 Di-iron ligands [ion binding]; other site 573569002318 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 573569002319 short chain dehydrogenase; Provisional; Region: PRK06101 573569002320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573569002321 NAD(P) binding site [chemical binding]; other site 573569002322 active site 573569002323 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 573569002324 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 573569002325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569002326 S-adenosylmethionine binding site [chemical binding]; other site 573569002327 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 573569002328 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 573569002329 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573569002330 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573569002331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573569002332 dimer interface [polypeptide binding]; other site 573569002333 phosphorylation site [posttranslational modification] 573569002334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573569002335 ATP binding site [chemical binding]; other site 573569002336 Mg2+ binding site [ion binding]; other site 573569002337 G-X-G motif; other site 573569002338 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573569002339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573569002340 active site 573569002341 phosphorylation site [posttranslational modification] 573569002342 intermolecular recognition site; other site 573569002343 dimerization interface [polypeptide binding]; other site 573569002344 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573569002345 DNA binding site [nucleotide binding] 573569002346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569002347 S-adenosylmethionine binding site [chemical binding]; other site 573569002348 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 573569002349 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 573569002350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 573569002351 ornithine cyclodeaminase; Validated; Region: PRK07589 573569002352 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 573569002353 Arginase family; Region: Arginase; cd09989 573569002354 active site 573569002355 Mn binding site [ion binding]; other site 573569002356 oligomer interface [polypeptide binding]; other site 573569002357 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 573569002358 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 573569002359 active site 573569002360 Protein of unknown function (DUF465); Region: DUF465; pfam04325 573569002361 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 573569002362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569002363 putative substrate translocation pore; other site 573569002364 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 573569002365 CoenzymeA binding site [chemical binding]; other site 573569002366 subunit interaction site [polypeptide binding]; other site 573569002367 PHB binding site; other site 573569002368 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 573569002369 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 573569002370 dimer interface [polypeptide binding]; other site 573569002371 active site 573569002372 Acyl CoA binding protein; Region: ACBP; pfam00887 573569002373 acyl-CoA binding pocket [chemical binding]; other site 573569002374 CoA binding site [chemical binding]; other site 573569002375 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 573569002376 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 573569002377 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 573569002378 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 573569002379 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 573569002380 substrate binding site [chemical binding]; other site 573569002381 oxyanion hole (OAH) forming residues; other site 573569002382 trimer interface [polypeptide binding]; other site 573569002383 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 573569002384 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 573569002385 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 573569002386 active site 573569002387 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 573569002388 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 573569002389 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 573569002390 acyl-activating enzyme (AAE) consensus motif; other site 573569002391 putative AMP binding site [chemical binding]; other site 573569002392 putative active site [active] 573569002393 putative CoA binding site [chemical binding]; other site 573569002394 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 573569002395 ArsC family; Region: ArsC; pfam03960 573569002396 catalytic residues [active] 573569002397 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 573569002398 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 573569002399 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 573569002400 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573569002401 ATP binding site [chemical binding]; other site 573569002402 putative Mg++ binding site [ion binding]; other site 573569002403 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573569002404 nucleotide binding region [chemical binding]; other site 573569002405 ATP-binding site [chemical binding]; other site 573569002406 Helicase associated domain (HA2); Region: HA2; pfam04408 573569002407 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 573569002408 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 573569002409 dsRNA-gated channel SID-1; Region: SID-1_RNA_chan; pfam13965 573569002410 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 573569002411 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 573569002412 NAD(P) binding site [chemical binding]; other site 573569002413 homodimer interface [polypeptide binding]; other site 573569002414 substrate binding site [chemical binding]; other site 573569002415 active site 573569002416 Bacterial sugar transferase; Region: Bac_transf; pfam02397 573569002417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573569002418 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 573569002419 NAD(P) binding site [chemical binding]; other site 573569002420 active site 573569002421 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 573569002422 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 573569002423 Substrate binding site; other site 573569002424 Cupin domain; Region: Cupin_2; cl17218 573569002425 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 573569002426 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 573569002427 NADP-binding site; other site 573569002428 homotetramer interface [polypeptide binding]; other site 573569002429 substrate binding site [chemical binding]; other site 573569002430 homodimer interface [polypeptide binding]; other site 573569002431 active site 573569002432 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 573569002433 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 573569002434 NADP binding site [chemical binding]; other site 573569002435 active site 573569002436 putative substrate binding site [chemical binding]; other site 573569002437 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 573569002438 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 573569002439 substrate binding site; other site 573569002440 tetramer interface; other site 573569002441 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 573569002442 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 573569002443 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 573569002444 NADP binding site [chemical binding]; other site 573569002445 active site 573569002446 putative substrate binding site [chemical binding]; other site 573569002447 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 573569002448 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 573569002449 NAD binding site [chemical binding]; other site 573569002450 substrate binding site [chemical binding]; other site 573569002451 homodimer interface [polypeptide binding]; other site 573569002452 active site 573569002453 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 573569002454 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573569002455 inhibitor-cofactor binding pocket; inhibition site 573569002456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569002457 catalytic residue [active] 573569002458 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 573569002459 trimer interface [polypeptide binding]; other site 573569002460 active site 573569002461 substrate binding site [chemical binding]; other site 573569002462 CoA binding site [chemical binding]; other site 573569002463 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573569002464 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573569002465 active site 573569002466 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 573569002467 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573569002468 inhibitor-cofactor binding pocket; inhibition site 573569002469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569002470 catalytic residue [active] 573569002471 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 573569002472 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 573569002473 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 573569002474 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 573569002475 Ligand binding site; other site 573569002476 Putative Catalytic site; other site 573569002477 DXD motif; other site 573569002478 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 573569002479 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573569002480 inhibitor-cofactor binding pocket; inhibition site 573569002481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569002482 catalytic residue [active] 573569002483 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573569002484 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 573569002485 Ligand binding site; other site 573569002486 Putative Catalytic site; other site 573569002487 DXD motif; other site 573569002488 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 573569002489 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 573569002490 putative trimer interface [polypeptide binding]; other site 573569002491 putative CoA binding site [chemical binding]; other site 573569002492 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 573569002493 active site 573569002494 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 573569002495 WbqC-like protein family; Region: WbqC; pfam08889 573569002496 WxcM-like, C-terminal; Region: FdtA; pfam05523 573569002497 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 573569002498 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 573569002499 putative trimer interface [polypeptide binding]; other site 573569002500 putative active site [active] 573569002501 putative substrate binding site [chemical binding]; other site 573569002502 putative CoA binding site [chemical binding]; other site 573569002503 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573569002504 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573569002505 Rhamnan synthesis protein F; Region: RgpF; pfam05045 573569002506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573569002507 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573569002508 Rhamnan synthesis protein F; Region: RgpF; pfam05045 573569002509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573569002510 NAD(P) binding site [chemical binding]; other site 573569002511 active site 573569002512 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573569002513 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573569002514 active site 573569002515 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573569002516 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 573569002517 ABC-2 type transporter; Region: ABC2_membrane; cl17235 573569002518 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 573569002519 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 573569002520 Walker A/P-loop; other site 573569002521 ATP binding site [chemical binding]; other site 573569002522 Q-loop/lid; other site 573569002523 ABC transporter signature motif; other site 573569002524 Walker B; other site 573569002525 D-loop; other site 573569002526 H-loop/switch region; other site 573569002527 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 573569002528 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573569002529 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573569002530 active site 573569002531 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 573569002532 metal-binding site 573569002533 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573569002534 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573569002535 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573569002536 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573569002537 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 573569002538 metal-binding site 573569002539 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 573569002540 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 573569002541 active site 573569002542 substrate binding site [chemical binding]; other site 573569002543 metal binding site [ion binding]; metal-binding site 573569002544 transcription termination factor Rho; Provisional; Region: rho; PRK09376 573569002545 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 573569002546 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 573569002547 RNA binding site [nucleotide binding]; other site 573569002548 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 573569002549 multimer interface [polypeptide binding]; other site 573569002550 Walker A motif; other site 573569002551 ATP binding site [chemical binding]; other site 573569002552 Walker B motif; other site 573569002553 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573569002554 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573569002555 catalytic residues [active] 573569002556 exopolyphosphatase; Region: exo_poly_only; TIGR03706 573569002557 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 573569002558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573569002559 Walker A motif; other site 573569002560 ATP binding site [chemical binding]; other site 573569002561 Walker B motif; other site 573569002562 recombination factor protein RarA; Provisional; Region: PRK14700 573569002563 arginine finger; other site 573569002564 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 573569002565 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 573569002566 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573569002567 dimer interface [polypeptide binding]; other site 573569002568 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 573569002569 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573569002570 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573569002571 active site 573569002572 DNA binding site [nucleotide binding] 573569002573 Int/Topo IB signature motif; other site 573569002574 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 573569002575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 573569002576 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 573569002577 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 573569002578 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573569002579 active site 573569002580 Int/Topo IB signature motif; other site 573569002581 Helix-turn-helix domain; Region: HTH_39; pfam14090 573569002582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 573569002583 Toprim domain; Region: Toprim_3; pfam13362 573569002584 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 573569002585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573569002586 non-specific DNA binding site [nucleotide binding]; other site 573569002587 salt bridge; other site 573569002588 sequence-specific DNA binding site [nucleotide binding]; other site 573569002589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569002590 putative substrate translocation pore; other site 573569002591 potential frameshift: common BLAST hit: gi|167623095|ref|YP_001673389.1| C4-dicarboxylate transporter/malic acid transport protein 573569002592 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 573569002593 gating phenylalanine in ion channel; other site 573569002594 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 573569002595 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 573569002596 active site 573569002597 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573569002598 Cupin domain; Region: Cupin_2; cl17218 573569002599 Protein of unknown function (DUF523); Region: DUF523; cl00733 573569002600 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573569002601 hypothetical protein; Provisional; Region: PRK10621 573569002602 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573569002603 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 573569002604 Walker A/P-loop; other site 573569002605 ATP binding site [chemical binding]; other site 573569002606 Q-loop/lid; other site 573569002607 ABC transporter signature motif; other site 573569002608 Walker B; other site 573569002609 D-loop; other site 573569002610 H-loop/switch region; other site 573569002611 inner membrane transport permease; Provisional; Region: PRK15066 573569002612 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 573569002613 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 573569002614 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 573569002615 Ligand binding site; other site 573569002616 Putative Catalytic site; other site 573569002617 DXD motif; other site 573569002618 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 573569002619 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 573569002620 LysE type translocator; Region: LysE; cl00565 573569002621 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 573569002622 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573569002623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573569002624 Coenzyme A binding pocket [chemical binding]; other site 573569002625 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 573569002626 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 573569002627 active site 573569002628 dimer interface [polypeptide binding]; other site 573569002629 guanine deaminase; Provisional; Region: PRK09228 573569002630 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573569002631 active site 573569002632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569002633 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573569002634 putative substrate translocation pore; other site 573569002635 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573569002636 dimerization interface [polypeptide binding]; other site 573569002637 putative DNA binding site [nucleotide binding]; other site 573569002638 putative Zn2+ binding site [ion binding]; other site 573569002639 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607 573569002640 active site residue [active] 573569002641 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 573569002642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573569002643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573569002644 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573569002645 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 573569002646 active site residue [active] 573569002647 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 573569002648 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573569002649 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 573569002650 hypothetical protein; Provisional; Region: PRK05170 573569002651 transcription antitermination factor NusB; Region: nusB; TIGR01951 573569002652 putative RNA binding site [nucleotide binding]; other site 573569002653 C-N hydrolase family amidase; Provisional; Region: PRK10438 573569002654 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 573569002655 putative active site [active] 573569002656 catalytic triad [active] 573569002657 dimer interface [polypeptide binding]; other site 573569002658 multimer interface [polypeptide binding]; other site 573569002659 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 573569002660 methionine aminotransferase; Validated; Region: PRK09082 573569002661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573569002662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569002663 homodimer interface [polypeptide binding]; other site 573569002664 catalytic residue [active] 573569002665 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573569002666 prolyl-tRNA synthetase; Provisional; Region: PRK09194 573569002667 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 573569002668 dimer interface [polypeptide binding]; other site 573569002669 motif 1; other site 573569002670 active site 573569002671 motif 2; other site 573569002672 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 573569002673 putative deacylase active site [active] 573569002674 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573569002675 active site 573569002676 motif 3; other site 573569002677 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 573569002678 anticodon binding site; other site 573569002679 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 573569002680 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 573569002681 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 573569002682 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 573569002683 active site 573569002684 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 573569002685 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 573569002686 Sporulation related domain; Region: SPOR; pfam05036 573569002687 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 573569002688 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 573569002689 active site 573569002690 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 573569002691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573569002692 non-specific DNA binding site [nucleotide binding]; other site 573569002693 salt bridge; other site 573569002694 sequence-specific DNA binding site [nucleotide binding]; other site 573569002695 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573569002696 Catalytic site [active] 573569002697 EamA-like transporter family; Region: EamA; pfam00892 573569002698 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 573569002699 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 573569002700 active site 573569002701 FMN binding site [chemical binding]; other site 573569002702 substrate binding site [chemical binding]; other site 573569002703 3Fe-4S cluster binding site [ion binding]; other site 573569002704 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 573569002705 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 573569002706 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 573569002707 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 573569002708 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 573569002709 diaminopimelate decarboxylase; Region: lysA; TIGR01048 573569002710 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 573569002711 dimer interface [polypeptide binding]; other site 573569002712 active site 573569002713 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573569002714 catalytic residues [active] 573569002715 substrate binding site [chemical binding]; other site 573569002716 Urea transporter; Region: UT; pfam03253 573569002717 Peptidase family M23; Region: Peptidase_M23; pfam01551 573569002718 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 573569002719 putative active site [active] 573569002720 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 573569002721 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 573569002722 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 573569002723 active site 573569002724 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 573569002725 Family description; Region: UvrD_C_2; pfam13538 573569002726 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 573569002727 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 573569002728 AAA domain; Region: AAA_30; pfam13604 573569002729 Family description; Region: UvrD_C_2; pfam13538 573569002730 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573569002731 nucleotide binding site [chemical binding]; other site 573569002732 Type III pantothenate kinase; Region: Pan_kinase; cl17198 573569002733 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 573569002734 tetramerization interface [polypeptide binding]; other site 573569002735 active site 573569002736 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573569002737 pantoate--beta-alanine ligase; Region: panC; TIGR00018 573569002738 active site 573569002739 nucleotide binding site [chemical binding]; other site 573569002740 HIGH motif; other site 573569002741 KMSKS motif; other site 573569002742 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 573569002743 active site 573569002744 oligomerization interface [polypeptide binding]; other site 573569002745 metal binding site [ion binding]; metal-binding site 573569002746 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 573569002747 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 573569002748 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 573569002749 nucleotide binding pocket [chemical binding]; other site 573569002750 K-X-D-G motif; other site 573569002751 catalytic site [active] 573569002752 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 573569002753 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 573569002754 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 573569002755 Dimer interface [polypeptide binding]; other site 573569002756 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573569002757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573569002758 Coenzyme A binding pocket [chemical binding]; other site 573569002759 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 573569002760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573569002761 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573569002762 Coenzyme A binding pocket [chemical binding]; other site 573569002763 16S rRNA methyltransferase B; Provisional; Region: PRK10901 573569002764 NusB family; Region: NusB; pfam01029 573569002765 putative RNA binding site [nucleotide binding]; other site 573569002766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569002767 S-adenosylmethionine binding site [chemical binding]; other site 573569002768 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 573569002769 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 573569002770 active site 573569002771 dimerization interface [polypeptide binding]; other site 573569002772 Predicted membrane protein [Function unknown]; Region: COG2855 573569002773 putative transporter; Provisional; Region: PRK03699 573569002774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569002775 Uncharacterized conserved protein [Function unknown]; Region: COG4121 573569002776 YCII-related domain; Region: YCII; cl00999 573569002777 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 573569002778 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 573569002779 dimer interface [polypeptide binding]; other site 573569002780 active site 573569002781 acyl carrier protein; Provisional; Region: acpP; PRK00982 573569002782 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 573569002783 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 573569002784 NAD(P) binding site [chemical binding]; other site 573569002785 homotetramer interface [polypeptide binding]; other site 573569002786 homodimer interface [polypeptide binding]; other site 573569002787 active site 573569002788 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 573569002789 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 573569002790 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 573569002791 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 573569002792 dimer interface [polypeptide binding]; other site 573569002793 active site 573569002794 CoA binding pocket [chemical binding]; other site 573569002795 putative phosphate acyltransferase; Provisional; Region: PRK05331 573569002796 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 573569002797 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 573569002798 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 573569002799 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 573569002800 TPP-binding site [chemical binding]; other site 573569002801 dimer interface [polypeptide binding]; other site 573569002802 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573569002803 PYR/PP interface [polypeptide binding]; other site 573569002804 dimer interface [polypeptide binding]; other site 573569002805 TPP binding site [chemical binding]; other site 573569002806 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573569002807 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 573569002808 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 573569002809 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 573569002810 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 573569002811 Phosphoglycerate kinase; Region: PGK; pfam00162 573569002812 substrate binding site [chemical binding]; other site 573569002813 hinge regions; other site 573569002814 ADP binding site [chemical binding]; other site 573569002815 catalytic site [active] 573569002816 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 573569002817 pyruvate kinase; Provisional; Region: PRK05826 573569002818 domain interfaces; other site 573569002819 active site 573569002820 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 573569002821 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 573569002822 intersubunit interface [polypeptide binding]; other site 573569002823 active site 573569002824 zinc binding site [ion binding]; other site 573569002825 Na+ binding site [ion binding]; other site 573569002826 Trehalase; Region: Trehalase; cl17346 573569002827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569002828 putative substrate translocation pore; other site 573569002829 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573569002830 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 573569002831 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 573569002832 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 573569002833 Protein of unknown function (DUF877); Region: DUF877; pfam05943 573569002834 Intracellular growth locus C protein; Region: IglC; pfam11550 573569002835 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 573569002836 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 573569002837 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 573569002838 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 573569002839 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 573569002840 dimer interface [polypeptide binding]; other site 573569002841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569002842 catalytic residue [active] 573569002843 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 573569002844 active site 573569002845 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 573569002846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573569002847 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573569002848 putative DNA binding site [nucleotide binding]; other site 573569002849 putative Zn2+ binding site [ion binding]; other site 573569002850 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573569002851 dimerization interface [polypeptide binding]; other site 573569002852 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 573569002853 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 573569002854 trmE is a tRNA modification GTPase; Region: trmE; cd04164 573569002855 G1 box; other site 573569002856 GTP/Mg2+ binding site [chemical binding]; other site 573569002857 Switch I region; other site 573569002858 G2 box; other site 573569002859 Switch II region; other site 573569002860 G3 box; other site 573569002861 G4 box; other site 573569002862 G5 box; other site 573569002863 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 573569002864 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 573569002865 30S subunit binding site; other site 573569002866 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573569002867 active site 573569002868 phosphorylation site [posttranslational modification] 573569002869 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 573569002870 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 573569002871 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 573569002872 RNA/DNA hybrid binding site [nucleotide binding]; other site 573569002873 active site 573569002874 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 573569002875 Na binding site [ion binding]; other site 573569002876 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 573569002877 PAS fold; Region: PAS_4; pfam08448 573569002878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 573569002879 putative active site [active] 573569002880 heme pocket [chemical binding]; other site 573569002881 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 573569002882 Amidohydrolase; Region: Amidohydro_5; pfam13594 573569002883 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 573569002884 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 573569002885 active site 573569002886 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 573569002887 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 573569002888 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 573569002889 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 573569002890 23S rRNA interface [nucleotide binding]; other site 573569002891 L3 interface [polypeptide binding]; other site 573569002892 Predicted ATPase [General function prediction only]; Region: COG4637 573569002893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573569002894 Walker A/P-loop; other site 573569002895 ATP binding site [chemical binding]; other site 573569002896 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573569002897 ABC transporter signature motif; other site 573569002898 Walker B; other site 573569002899 D-loop; other site 573569002900 H-loop/switch region; other site 573569002901 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573569002902 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 573569002903 MltA specific insert domain; Region: MltA; smart00925 573569002904 3D domain; Region: 3D; pfam06725 573569002905 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 573569002906 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 573569002907 dimer interface [polypeptide binding]; other site 573569002908 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 573569002909 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 573569002910 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573569002911 nucleotide binding site [chemical binding]; other site 573569002912 chaperone protein DnaJ; Provisional; Region: PRK10767 573569002913 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573569002914 HSP70 interaction site [polypeptide binding]; other site 573569002915 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 573569002916 substrate binding site [polypeptide binding]; other site 573569002917 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 573569002918 Zn binding sites [ion binding]; other site 573569002919 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 573569002920 dimer interface [polypeptide binding]; other site 573569002921 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 573569002922 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 573569002923 homodimer interface [polypeptide binding]; other site 573569002924 NAD binding pocket [chemical binding]; other site 573569002925 ATP binding pocket [chemical binding]; other site 573569002926 Mg binding site [ion binding]; other site 573569002927 active-site loop [active] 573569002928 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 573569002929 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 573569002930 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573569002931 HlyD family secretion protein; Region: HlyD_3; pfam13437 573569002932 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 573569002933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569002934 putative substrate translocation pore; other site 573569002935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569002936 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573569002937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573569002938 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 573569002939 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 573569002940 acyl-activating enzyme (AAE) consensus motif; other site 573569002941 putative active site [active] 573569002942 putative AMP binding site [chemical binding]; other site 573569002943 putative CoA binding site [chemical binding]; other site 573569002944 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 573569002945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569002946 putative substrate translocation pore; other site 573569002947 POT family; Region: PTR2; cl17359 573569002948 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 573569002949 RNA methyltransferase, RsmE family; Region: TIGR00046 573569002950 Protein of unknown function (DUF445); Region: DUF445; pfam04286 573569002951 mce related protein; Region: MCE; pfam02470 573569002952 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 573569002953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573569002954 Walker A/P-loop; other site 573569002955 ATP binding site [chemical binding]; other site 573569002956 Q-loop/lid; other site 573569002957 ABC transporter signature motif; other site 573569002958 Walker B; other site 573569002959 D-loop; other site 573569002960 H-loop/switch region; other site 573569002961 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 573569002962 Permease; Region: Permease; pfam02405 573569002963 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 573569002964 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 573569002965 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573569002966 RNA binding surface [nucleotide binding]; other site 573569002967 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573569002968 active site 573569002969 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 573569002970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573569002971 TPR motif; other site 573569002972 binding surface 573569002973 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 573569002974 FAD binding domain; Region: FAD_binding_4; pfam01565 573569002975 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 573569002976 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 573569002977 dimer interface [polypeptide binding]; other site 573569002978 active site 573569002979 glycine-pyridoxal phosphate binding site [chemical binding]; other site 573569002980 folate binding site [chemical binding]; other site 573569002981 hypothetical protein; Provisional; Region: PRK05255 573569002982 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 573569002983 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 573569002984 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573569002985 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573569002986 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 573569002987 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 573569002988 active site 573569002989 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 573569002990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569002991 POT family; Region: PTR2; cl17359 573569002992 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 573569002993 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 573569002994 Ligand Binding Site [chemical binding]; other site 573569002995 TilS substrate C-terminal domain; Region: TilS_C; smart00977 573569002996 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 573569002997 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 573569002998 ligand binding site [chemical binding]; other site 573569002999 NAD binding site [chemical binding]; other site 573569003000 tetramer interface [polypeptide binding]; other site 573569003001 catalytic site [active] 573569003002 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 573569003003 L-serine binding site [chemical binding]; other site 573569003004 ACT domain interface; other site 573569003005 thymidylate synthase; Reviewed; Region: thyA; PRK01827 573569003006 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 573569003007 dimerization interface [polypeptide binding]; other site 573569003008 active site 573569003009 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 573569003010 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 573569003011 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 573569003012 homodimer interface [polypeptide binding]; other site 573569003013 oligonucleotide binding site [chemical binding]; other site 573569003014 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 573569003015 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 573569003016 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573569003017 catalytic residue [active] 573569003018 Recombination protein O C terminal; Region: RecO_C; pfam02565 573569003019 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573569003020 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 573569003021 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 573569003022 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573569003023 BolA-like protein; Region: BolA; cl00386 573569003024 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 573569003025 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 573569003026 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 573569003027 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 573569003028 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 573569003029 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 573569003030 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 573569003031 active site 573569003032 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 573569003033 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 573569003034 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573569003035 ATP binding site [chemical binding]; other site 573569003036 putative Mg++ binding site [ion binding]; other site 573569003037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573569003038 nucleotide binding region [chemical binding]; other site 573569003039 ATP-binding site [chemical binding]; other site 573569003040 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 573569003041 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 573569003042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573569003043 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 573569003044 active site 573569003045 motif I; other site 573569003046 motif II; other site 573569003047 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573569003048 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 573569003049 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573569003050 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 573569003051 dimer interface [polypeptide binding]; other site 573569003052 active site 573569003053 metal binding site [ion binding]; metal-binding site 573569003054 glutathione binding site [chemical binding]; other site 573569003055 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573569003056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569003057 S-adenosylmethionine binding site [chemical binding]; other site 573569003058 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 573569003059 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 573569003060 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 573569003061 NAD binding site [chemical binding]; other site 573569003062 homotetramer interface [polypeptide binding]; other site 573569003063 homodimer interface [polypeptide binding]; other site 573569003064 substrate binding site [chemical binding]; other site 573569003065 active site 573569003066 hypothetical protein; Provisional; Region: PRK05409 573569003067 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 573569003068 DoxX; Region: DoxX; pfam07681 573569003069 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 573569003070 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 573569003071 putative active site [active] 573569003072 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 573569003073 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 573569003074 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 573569003075 substrate binding site [chemical binding]; other site 573569003076 hexamer interface [polypeptide binding]; other site 573569003077 metal binding site [ion binding]; metal-binding site 573569003078 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 573569003079 Bacterial sugar transferase; Region: Bac_transf; pfam02397 573569003080 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 573569003081 active site 573569003082 NTP binding site [chemical binding]; other site 573569003083 metal binding triad [ion binding]; metal-binding site 573569003084 antibiotic binding site [chemical binding]; other site 573569003085 UDP-glucose 4-epimerase; Region: PLN02240 573569003086 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 573569003087 NAD binding site [chemical binding]; other site 573569003088 homodimer interface [polypeptide binding]; other site 573569003089 active site 573569003090 substrate binding site [chemical binding]; other site 573569003091 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573569003092 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 573569003093 putative ADP-binding pocket [chemical binding]; other site 573569003094 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573569003095 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573569003096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573569003097 Walker A/P-loop; other site 573569003098 ATP binding site [chemical binding]; other site 573569003099 Q-loop/lid; other site 573569003100 ABC transporter signature motif; other site 573569003101 Walker B; other site 573569003102 D-loop; other site 573569003103 H-loop/switch region; other site 573569003104 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 573569003105 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573569003106 active site 573569003107 putative glycosyl transferase; Provisional; Region: PRK10073 573569003108 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573569003109 active site 573569003110 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573569003111 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 573569003112 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 573569003113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573569003114 motif II; other site 573569003115 Archaeal ATPase; Region: Arch_ATPase; pfam01637 573569003116 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 573569003117 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573569003118 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573569003119 substrate binding site [chemical binding]; other site 573569003120 ATP binding site [chemical binding]; other site 573569003121 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 573569003122 proposed catalytic triad [active] 573569003123 active site nucleophile [active] 573569003124 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 573569003125 catalytic nucleophile [active] 573569003126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003127 metabolite-proton symporter; Region: 2A0106; TIGR00883 573569003128 putative substrate translocation pore; other site 573569003129 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 573569003130 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 573569003131 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 573569003132 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 573569003133 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573569003134 Zn2+ binding site [ion binding]; other site 573569003135 Mg2+ binding site [ion binding]; other site 573569003136 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 573569003137 synthetase active site [active] 573569003138 NTP binding site [chemical binding]; other site 573569003139 metal binding site [ion binding]; metal-binding site 573569003140 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 573569003141 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 573569003142 recombination protein RecR; Provisional; Region: PRK13844 573569003143 RecR protein; Region: RecR; pfam02132 573569003144 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 573569003145 putative active site [active] 573569003146 putative metal-binding site [ion binding]; other site 573569003147 tetramer interface [polypeptide binding]; other site 573569003148 hypothetical protein; Validated; Region: PRK00153 573569003149 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 573569003150 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 573569003151 homodimer interface [polypeptide binding]; other site 573569003152 active site 573569003153 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 573569003154 lipoyl attachment site [posttranslational modification]; other site 573569003155 Chitin binding domain; Region: Chitin_bind_3; pfam03067 573569003156 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 573569003157 aromatic chitin/cellulose binding site residues [chemical binding]; other site 573569003158 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 573569003159 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 573569003160 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573569003161 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 573569003162 active site 573569003163 dimer interface [polypeptide binding]; other site 573569003164 motif 1; other site 573569003165 motif 2; other site 573569003166 motif 3; other site 573569003167 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 573569003168 anticodon binding site; other site 573569003169 translation initiation factor IF-3; Region: infC; TIGR00168 573569003170 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 573569003171 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 573569003172 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 573569003173 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 573569003174 23S rRNA binding site [nucleotide binding]; other site 573569003175 L21 binding site [polypeptide binding]; other site 573569003176 L13 binding site [polypeptide binding]; other site 573569003177 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 573569003178 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 573569003179 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573569003180 active site 573569003181 dimer interface [polypeptide binding]; other site 573569003182 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 573569003183 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 573569003184 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 573569003185 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 573569003186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573569003187 LysR family transcriptional regulator; Provisional; Region: PRK14997 573569003188 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 573569003189 putative effector binding pocket; other site 573569003190 dimerization interface [polypeptide binding]; other site 573569003191 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 573569003192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573569003193 NAD(P) binding site [chemical binding]; other site 573569003194 active site 573569003195 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 573569003196 active site 573569003197 catalytic site [active] 573569003198 substrate binding site [chemical binding]; other site 573569003199 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 573569003200 excinuclease ABC subunit B; Provisional; Region: PRK05298 573569003201 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573569003202 ATP binding site [chemical binding]; other site 573569003203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573569003204 nucleotide binding region [chemical binding]; other site 573569003205 ATP-binding site [chemical binding]; other site 573569003206 Ultra-violet resistance protein B; Region: UvrB; pfam12344 573569003207 UvrB/uvrC motif; Region: UVR; pfam02151 573569003208 Nuclease-related domain; Region: NERD; pfam08378 573569003209 glutamate racemase; Provisional; Region: PRK00865 573569003210 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 573569003211 ThiC-associated domain; Region: ThiC-associated; pfam13667 573569003212 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 573569003213 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 573569003214 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 573569003215 thiS-thiF/thiG interaction site; other site 573569003216 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 573569003217 ThiS interaction site; other site 573569003218 putative active site [active] 573569003219 tetramer interface [polypeptide binding]; other site 573569003220 HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898 573569003221 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 573569003222 substrate binding site [chemical binding]; other site 573569003223 dimer interface [polypeptide binding]; other site 573569003224 ATP binding site [chemical binding]; other site 573569003225 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 573569003226 thiamine phosphate binding site [chemical binding]; other site 573569003227 active site 573569003228 pyrophosphate binding site [ion binding]; other site 573569003229 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 573569003230 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 573569003231 ATP binding site [chemical binding]; other site 573569003232 substrate interface [chemical binding]; other site 573569003233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003234 metabolite-proton symporter; Region: 2A0106; TIGR00883 573569003235 putative substrate translocation pore; other site 573569003236 metabolite-proton symporter; Region: 2A0106; TIGR00883 573569003237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003238 putative substrate translocation pore; other site 573569003239 Uncharacterized conserved protein [Function unknown]; Region: COG2308 573569003240 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 573569003241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 573569003242 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 573569003243 putative dimer interface [polypeptide binding]; other site 573569003244 putative active site [active] 573569003245 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 573569003246 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 573569003247 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573569003248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573569003249 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 573569003250 Coenzyme A binding pocket [chemical binding]; other site 573569003251 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 573569003252 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 573569003253 generic binding surface II; other site 573569003254 generic binding surface I; other site 573569003255 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 573569003256 putative active site [active] 573569003257 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 573569003258 putative active site [active] 573569003259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003260 metabolite-proton symporter; Region: 2A0106; TIGR00883 573569003261 putative substrate translocation pore; other site 573569003262 Trp repressor protein; Region: Trp_repressor; cl17266 573569003263 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 573569003264 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 573569003265 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 573569003266 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 573569003267 histidinol dehydrogenase; Region: hisD; TIGR00069 573569003268 NAD binding site [chemical binding]; other site 573569003269 dimerization interface [polypeptide binding]; other site 573569003270 product binding site; other site 573569003271 substrate binding site [chemical binding]; other site 573569003272 zinc binding site [ion binding]; other site 573569003273 catalytic residues [active] 573569003274 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 573569003275 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573569003276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569003277 homodimer interface [polypeptide binding]; other site 573569003278 catalytic residue [active] 573569003279 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 573569003280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573569003281 active site 573569003282 motif I; other site 573569003283 motif II; other site 573569003284 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 573569003285 putative active site pocket [active] 573569003286 4-fold oligomerization interface [polypeptide binding]; other site 573569003287 metal binding residues [ion binding]; metal-binding site 573569003288 3-fold/trimer interface [polypeptide binding]; other site 573569003289 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 573569003290 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 573569003291 putative active site [active] 573569003292 oxyanion strand; other site 573569003293 catalytic triad [active] 573569003294 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 573569003295 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 573569003296 catalytic residues [active] 573569003297 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 573569003298 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 573569003299 substrate binding site [chemical binding]; other site 573569003300 glutamase interaction surface [polypeptide binding]; other site 573569003301 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 573569003302 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 573569003303 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 573569003304 metal binding site [ion binding]; metal-binding site 573569003305 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 573569003306 B1 nucleotide binding pocket [chemical binding]; other site 573569003307 B2 nucleotide binding pocket [chemical binding]; other site 573569003308 CAS motifs; other site 573569003309 active site 573569003310 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 573569003311 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 573569003312 Ligand Binding Site [chemical binding]; other site 573569003313 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 573569003314 SmpB-tmRNA interface; other site 573569003315 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 573569003316 putative coenzyme Q binding site [chemical binding]; other site 573569003317 hypothetical protein; Validated; Region: PRK01777 573569003318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573569003319 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 573569003320 VacJ like lipoprotein; Region: VacJ; cl01073 573569003321 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 573569003322 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 573569003323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573569003324 short chain dehydrogenase; Validated; Region: PRK07069 573569003325 NAD(P) binding site [chemical binding]; other site 573569003326 active site 573569003327 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 573569003328 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 573569003329 G1 box; other site 573569003330 putative GEF interaction site [polypeptide binding]; other site 573569003331 GTP/Mg2+ binding site [chemical binding]; other site 573569003332 Switch I region; other site 573569003333 G2 box; other site 573569003334 G3 box; other site 573569003335 Switch II region; other site 573569003336 G4 box; other site 573569003337 G5 box; other site 573569003338 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 573569003339 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 573569003340 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 573569003341 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573569003342 catalytic residue [active] 573569003343 Rubredoxin [Energy production and conversion]; Region: COG1773 573569003344 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 573569003345 iron binding site [ion binding]; other site 573569003346 hypothetical protein; Validated; Region: PRK00029 573569003347 Uncharacterized conserved protein [Function unknown]; Region: COG0397 573569003348 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 573569003349 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 573569003350 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 573569003351 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 573569003352 dimer interface [polypeptide binding]; other site 573569003353 active site 573569003354 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 573569003355 dimer interface [polypeptide binding]; other site 573569003356 active site 573569003357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003358 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 573569003359 putative substrate translocation pore; other site 573569003360 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 573569003361 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 573569003362 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 573569003363 active site 573569003364 Uncharacterized conserved protein [Function unknown]; Region: COG0327 573569003365 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 573569003366 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 573569003367 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 573569003368 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 573569003369 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 573569003370 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 573569003371 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 573569003372 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 573569003373 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 573569003374 active site 573569003375 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 573569003376 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 573569003377 active site 573569003378 substrate binding site [chemical binding]; other site 573569003379 Mg2+ binding site [ion binding]; other site 573569003380 beta-lactamase TEM; Provisional; Region: PRK15442 573569003381 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 573569003382 Bor protein; Region: Lambda_Bor; pfam06291 573569003383 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 573569003384 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 573569003385 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 573569003386 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 573569003387 putative active site [active] 573569003388 catalytic triad [active] 573569003389 putative dimer interface [polypeptide binding]; other site 573569003390 FOG: CBS domain [General function prediction only]; Region: COG0517 573569003391 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573569003392 Transporter associated domain; Region: CorC_HlyC; smart01091 573569003393 metal-binding heat shock protein; Provisional; Region: PRK00016 573569003394 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 573569003395 PhoH-like protein; Region: PhoH; pfam02562 573569003396 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 573569003397 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573569003398 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573569003399 FeS/SAM binding site; other site 573569003400 TRAM domain; Region: TRAM; pfam01938 573569003401 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 573569003402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573569003403 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 573569003404 thymidine kinase; Provisional; Region: PRK04296 573569003405 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573569003406 Sel1-like repeats; Region: SEL1; smart00671 573569003407 Sel1-like repeats; Region: SEL1; smart00671 573569003408 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 573569003409 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 573569003410 GTP/Mg2+ binding site [chemical binding]; other site 573569003411 G4 box; other site 573569003412 G5 box; other site 573569003413 G1 box; other site 573569003414 Switch I region; other site 573569003415 G2 box; other site 573569003416 G3 box; other site 573569003417 Switch II region; other site 573569003418 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 573569003419 Glycoprotease family; Region: Peptidase_M22; pfam00814 573569003420 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 573569003421 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 573569003422 putative active site [active] 573569003423 putative dimer interface [polypeptide binding]; other site 573569003424 aspartate aminotransferase; Provisional; Region: PRK05764 573569003425 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573569003426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569003427 homodimer interface [polypeptide binding]; other site 573569003428 catalytic residue [active] 573569003429 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 573569003430 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 573569003431 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 573569003432 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 573569003433 DsbD alpha interface [polypeptide binding]; other site 573569003434 catalytic residues [active] 573569003435 GTPase Era; Reviewed; Region: era; PRK00089 573569003436 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 573569003437 G1 box; other site 573569003438 GTP/Mg2+ binding site [chemical binding]; other site 573569003439 Switch I region; other site 573569003440 G2 box; other site 573569003441 Switch II region; other site 573569003442 G3 box; other site 573569003443 G4 box; other site 573569003444 G5 box; other site 573569003445 KH domain; Region: KH_2; pfam07650 573569003446 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 573569003447 FAD binding domain; Region: FAD_binding_4; pfam01565 573569003448 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573569003449 adenylate kinase; Reviewed; Region: adk; PRK00279 573569003450 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 573569003451 AMP-binding site [chemical binding]; other site 573569003452 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 573569003453 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 573569003454 Pilus assembly protein, PilO; Region: PilO; cl01234 573569003455 Pilus assembly protein, PilP; Region: PilP; pfam04351 573569003456 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 573569003457 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 573569003458 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 573569003459 shikimate kinase; Reviewed; Region: aroK; PRK00131 573569003460 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 573569003461 ADP binding site [chemical binding]; other site 573569003462 magnesium binding site [ion binding]; other site 573569003463 putative shikimate binding site; other site 573569003464 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 573569003465 active site 573569003466 dimer interface [polypeptide binding]; other site 573569003467 metal binding site [ion binding]; metal-binding site 573569003468 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 573569003469 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 573569003470 Proline dehydrogenase; Region: Pro_dh; pfam01619 573569003471 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 573569003472 Glutamate binding site [chemical binding]; other site 573569003473 NAD binding site [chemical binding]; other site 573569003474 catalytic residues [active] 573569003475 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 573569003476 NAD(P) binding site [chemical binding]; other site 573569003477 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 573569003478 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 573569003479 benzoate transport; Region: 2A0115; TIGR00895 573569003480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003481 putative substrate translocation pore; other site 573569003482 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 573569003483 Flavoprotein; Region: Flavoprotein; pfam02441 573569003484 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 573569003485 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 573569003486 active site 573569003487 catalytic residues [active] 573569003488 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 573569003489 DNA photolyase; Region: DNA_photolyase; pfam00875 573569003490 ferrochelatase; Reviewed; Region: hemH; PRK00035 573569003491 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 573569003492 C-terminal domain interface [polypeptide binding]; other site 573569003493 active site 573569003494 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 573569003495 active site 573569003496 N-terminal domain interface [polypeptide binding]; other site 573569003497 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 573569003498 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 573569003499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569003500 S-adenosylmethionine binding site [chemical binding]; other site 573569003501 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 573569003502 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 573569003503 FMN binding site [chemical binding]; other site 573569003504 active site 573569003505 catalytic residues [active] 573569003506 substrate binding site [chemical binding]; other site 573569003507 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 573569003508 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 573569003509 active site 573569003510 DNA polymerase IV; Validated; Region: PRK02406 573569003511 DNA binding site [nucleotide binding] 573569003512 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 573569003513 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 573569003514 conserved cys residue [active] 573569003515 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573569003516 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573569003517 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573569003518 ABC transporter; Region: ABC_tran_2; pfam12848 573569003519 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573569003520 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 573569003521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003523 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573569003524 Beta-lactamase; Region: Beta-lactamase; cl17358 573569003525 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 573569003526 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 573569003527 GSH binding site [chemical binding]; other site 573569003528 catalytic residues [active] 573569003529 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 573569003530 dimer interface [polypeptide binding]; other site 573569003531 putative radical transfer pathway; other site 573569003532 diiron center [ion binding]; other site 573569003533 tyrosyl radical; other site 573569003534 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573569003535 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 573569003536 Class I ribonucleotide reductase; Region: RNR_I; cd01679 573569003537 active site 573569003538 dimer interface [polypeptide binding]; other site 573569003539 catalytic residues [active] 573569003540 effector binding site; other site 573569003541 R2 peptide binding site; other site 573569003542 malate dehydrogenase; Reviewed; Region: PRK06223 573569003543 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 573569003544 NAD(P) binding site [chemical binding]; other site 573569003545 dimer interface [polypeptide binding]; other site 573569003546 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573569003547 substrate binding site [chemical binding]; other site 573569003548 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 573569003549 diiron binding motif [ion binding]; other site 573569003550 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573569003551 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573569003552 catalytic residue [active] 573569003553 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 573569003554 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 573569003555 putative ATP binding site [chemical binding]; other site 573569003556 putative substrate interface [chemical binding]; other site 573569003557 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 573569003558 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573569003559 motif II; other site 573569003560 peroxidase; Provisional; Region: PRK15000 573569003561 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 573569003562 dimer interface [polypeptide binding]; other site 573569003563 decamer (pentamer of dimers) interface [polypeptide binding]; other site 573569003564 catalytic triad [active] 573569003565 peroxidatic and resolving cysteines [active] 573569003566 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 573569003567 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 573569003568 PhnA protein; Region: PhnA; pfam03831 573569003569 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 573569003570 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 573569003571 active site 573569003572 catalytic site [active] 573569003573 substrate binding site [chemical binding]; other site 573569003574 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 573569003575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 573569003576 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 573569003577 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 573569003578 aldehyde dehydrogenase family 7 member; Region: PLN02315 573569003579 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 573569003580 tetrameric interface [polypeptide binding]; other site 573569003581 NAD binding site [chemical binding]; other site 573569003582 catalytic residues [active] 573569003583 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 573569003584 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 573569003585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573569003586 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 573569003587 dimerization interface [polypeptide binding]; other site 573569003588 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 573569003589 catalytic triad [active] 573569003590 dimer interface [polypeptide binding]; other site 573569003591 short chain dehydrogenase; Provisional; Region: PRK07060 573569003592 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 573569003593 putative NAD(P) binding site [chemical binding]; other site 573569003594 homodimer interface [polypeptide binding]; other site 573569003595 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 573569003596 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 573569003597 heme binding pocket [chemical binding]; other site 573569003598 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573569003599 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573569003600 cytidylate kinase; Provisional; Region: cmk; PRK00023 573569003601 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 573569003602 CMP-binding site; other site 573569003603 The sites determining sugar specificity; other site 573569003604 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 573569003605 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573569003606 catalytic residue [active] 573569003607 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 573569003608 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 573569003609 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 573569003610 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 573569003611 active site residue [active] 573569003612 Cyclic phosphodiesterase-like protein; Region: CPDase; pfam07823 573569003613 recombination associated protein; Reviewed; Region: rdgC; PRK00321 573569003614 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 573569003615 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 573569003616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573569003617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569003618 S-adenosylmethionine binding site [chemical binding]; other site 573569003619 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 573569003620 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 573569003621 arsenical-resistance protein; Region: acr3; TIGR00832 573569003622 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573569003623 dimerization interface [polypeptide binding]; other site 573569003624 putative DNA binding site [nucleotide binding]; other site 573569003625 putative Zn2+ binding site [ion binding]; other site 573569003626 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 573569003627 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 573569003628 putative active site [active] 573569003629 substrate binding site [chemical binding]; other site 573569003630 putative cosubstrate binding site; other site 573569003631 catalytic site [active] 573569003632 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 573569003633 substrate binding site [chemical binding]; other site 573569003634 glutathione synthetase; Provisional; Region: PRK05246 573569003635 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 573569003636 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 573569003637 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 573569003638 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573569003639 inhibitor-cofactor binding pocket; inhibition site 573569003640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569003641 catalytic residue [active] 573569003642 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 573569003643 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 573569003644 Transcriptional regulator; Region: Rrf2; cl17282 573569003645 Rrf2 family protein; Region: rrf2_super; TIGR00738 573569003646 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 573569003647 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 573569003648 heme-binding site [chemical binding]; other site 573569003649 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 573569003650 FAD binding pocket [chemical binding]; other site 573569003651 FAD binding motif [chemical binding]; other site 573569003652 phosphate binding motif [ion binding]; other site 573569003653 beta-alpha-beta structure motif; other site 573569003654 NAD binding pocket [chemical binding]; other site 573569003655 Heme binding pocket [chemical binding]; other site 573569003656 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573569003657 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 573569003658 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 573569003659 classical (c) SDRs; Region: SDR_c; cd05233 573569003660 NAD(P) binding site [chemical binding]; other site 573569003661 active site 573569003662 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 573569003663 acetoacetate decarboxylase; Provisional; Region: PRK02265 573569003664 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 573569003665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003666 putative substrate translocation pore; other site 573569003667 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573569003668 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573569003669 nucleotide binding site [chemical binding]; other site 573569003670 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573569003671 dimerization interface [polypeptide binding]; other site 573569003672 putative DNA binding site [nucleotide binding]; other site 573569003673 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 573569003674 putative Zn2+ binding site [ion binding]; other site 573569003675 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 573569003676 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 573569003677 AAA domain; Region: AAA_26; pfam13500 573569003678 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 573569003679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569003680 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 573569003681 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 573569003682 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573569003683 catalytic residue [active] 573569003684 biotin synthase; Region: bioB; TIGR00433 573569003685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573569003686 FeS/SAM binding site; other site 573569003687 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 573569003688 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573569003689 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 573569003690 inhibitor-cofactor binding pocket; inhibition site 573569003691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569003692 catalytic residue [active] 573569003693 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557 573569003694 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 573569003695 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 573569003696 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 573569003697 catalytic center binding site [active] 573569003698 ATP binding site [chemical binding]; other site 573569003699 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 573569003700 dihydropteroate synthase; Region: DHPS; TIGR01496 573569003701 substrate binding pocket [chemical binding]; other site 573569003702 dimer interface [polypeptide binding]; other site 573569003703 inhibitor binding site; inhibition site 573569003704 Dihydroneopterin aldolase; Region: FolB; smart00905 573569003705 active site 573569003706 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 573569003707 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573569003708 acyl-activating enzyme (AAE) consensus motif; other site 573569003709 AMP binding site [chemical binding]; other site 573569003710 active site 573569003711 CoA binding site [chemical binding]; other site 573569003712 chorismate binding enzyme; Region: Chorismate_bind; cl10555 573569003713 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 573569003714 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 573569003715 substrate-cofactor binding pocket; other site 573569003716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569003717 homodimer interface [polypeptide binding]; other site 573569003718 catalytic residue [active] 573569003719 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 573569003720 Glutamine amidotransferase class-I; Region: GATase; pfam00117 573569003721 glutamine binding [chemical binding]; other site 573569003722 catalytic triad [active] 573569003723 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573569003724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003725 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573569003726 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573569003727 active site 573569003728 catalytic tetrad [active] 573569003729 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573569003730 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573569003731 active site 573569003732 catalytic tetrad [active] 573569003733 Predicted amidohydrolase [General function prediction only]; Region: COG0388 573569003734 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 573569003735 active site 573569003736 catalytic triad [active] 573569003737 dimer interface [polypeptide binding]; other site 573569003738 Uncharacterized conserved protein [Function unknown]; Region: COG1434 573569003739 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 573569003740 putative active site [active] 573569003741 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 573569003742 GTP cyclohydrolase I; Provisional; Region: PLN03044 573569003743 active site 573569003744 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 573569003745 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573569003746 ATP binding site [chemical binding]; other site 573569003747 Mg++ binding site [ion binding]; other site 573569003748 motif III; other site 573569003749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573569003750 nucleotide binding region [chemical binding]; other site 573569003751 ATP-binding site [chemical binding]; other site 573569003752 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 573569003753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003754 putative substrate translocation pore; other site 573569003755 Uncharacterized conserved protein [Function unknown]; Region: COG0393 573569003756 glutathione reductase; Validated; Region: PRK06116 573569003757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573569003758 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573569003759 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 573569003760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573569003761 AAA domain; Region: AAA_33; pfam13671 573569003762 Walker A motif; other site 573569003763 ATP binding site [chemical binding]; other site 573569003764 Walker B motif; other site 573569003765 Nuclease-related domain; Region: NERD; pfam08378 573569003766 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 573569003767 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 573569003768 putative active site [active] 573569003769 putative catalytic site [active] 573569003770 putative DNA binding site [nucleotide binding]; other site 573569003771 putative phosphate binding site [ion binding]; other site 573569003772 metal binding site A [ion binding]; metal-binding site 573569003773 putative AP binding site [nucleotide binding]; other site 573569003774 putative metal binding site B [ion binding]; other site 573569003775 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 573569003776 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 573569003777 active site 573569003778 Zn binding site [ion binding]; other site 573569003779 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 573569003780 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 573569003781 intracellular protease, PfpI family; Region: PfpI; TIGR01382 573569003782 potential catalytic triad [active] 573569003783 conserved cys residue [active] 573569003784 Bor protein; Region: Lambda_Bor; pfam06291 573569003785 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 573569003786 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 573569003787 signal recognition particle protein; Provisional; Region: PRK10867 573569003788 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 573569003789 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 573569003790 P loop; other site 573569003791 GTP binding site [chemical binding]; other site 573569003792 Signal peptide binding domain; Region: SRP_SPB; pfam02978 573569003793 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 573569003794 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573569003795 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 573569003796 rRNA binding site [nucleotide binding]; other site 573569003797 predicted 30S ribosome binding site; other site 573569003798 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 573569003799 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 573569003800 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 573569003801 TrkA-N domain; Region: TrkA_N; pfam02254 573569003802 TrkA-C domain; Region: TrkA_C; pfam02080 573569003803 TrkA-N domain; Region: TrkA_N; pfam02254 573569003804 TrkA-C domain; Region: TrkA_C; pfam02080 573569003805 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 573569003806 Transcriptional regulator; Region: Rrf2; pfam02082 573569003807 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 573569003808 putative ABC transporter; Region: ycf24; CHL00085 573569003809 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 573569003810 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 573569003811 Walker A/P-loop; other site 573569003812 ATP binding site [chemical binding]; other site 573569003813 Q-loop/lid; other site 573569003814 ABC transporter signature motif; other site 573569003815 Walker B; other site 573569003816 D-loop; other site 573569003817 H-loop/switch region; other site 573569003818 FeS assembly protein SufD; Region: sufD; TIGR01981 573569003819 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 573569003820 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573569003821 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573569003822 catalytic residues [active] 573569003823 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 573569003824 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 573569003825 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 573569003826 active site 573569003827 8-oxo-dGMP binding site [chemical binding]; other site 573569003828 nudix motif; other site 573569003829 metal binding site [ion binding]; metal-binding site 573569003830 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 573569003831 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 573569003832 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 573569003833 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 573569003834 HIGH motif; other site 573569003835 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 573569003836 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 573569003837 active site 573569003838 KMSKS motif; other site 573569003839 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 573569003840 tRNA binding surface [nucleotide binding]; other site 573569003841 Lipopolysaccharide-assembly; Region: LptE; cl01125 573569003842 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573569003843 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573569003844 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 573569003845 trimer interface [polypeptide binding]; other site 573569003846 active site 573569003847 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 573569003848 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 573569003849 Walker A motif; other site 573569003850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003851 metabolite-proton symporter; Region: 2A0106; TIGR00883 573569003852 putative substrate translocation pore; other site 573569003853 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 573569003854 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 573569003855 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 573569003856 putative active site [active] 573569003857 catalytic site [active] 573569003858 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 573569003859 putative active site [active] 573569003860 catalytic site [active] 573569003861 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 573569003862 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 573569003863 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 573569003864 putative active site [active] 573569003865 catalytic site [active] 573569003866 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 573569003867 putative active site [active] 573569003868 catalytic site [active] 573569003869 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 573569003870 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 573569003871 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 573569003872 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 573569003873 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 573569003874 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 573569003875 metal binding site 2 [ion binding]; metal-binding site 573569003876 putative DNA binding helix; other site 573569003877 metal binding site 1 [ion binding]; metal-binding site 573569003878 dimer interface [polypeptide binding]; other site 573569003879 structural Zn2+ binding site [ion binding]; other site 573569003880 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 573569003881 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573569003882 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 573569003883 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 573569003884 putative tRNA-binding site [nucleotide binding]; other site 573569003885 B3/4 domain; Region: B3_4; pfam03483 573569003886 tRNA synthetase B5 domain; Region: B5; smart00874 573569003887 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 573569003888 dimer interface [polypeptide binding]; other site 573569003889 motif 1; other site 573569003890 motif 3; other site 573569003891 motif 2; other site 573569003892 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 573569003893 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 573569003894 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 573569003895 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 573569003896 dimer interface [polypeptide binding]; other site 573569003897 motif 1; other site 573569003898 active site 573569003899 motif 2; other site 573569003900 motif 3; other site 573569003901 EamA-like transporter family; Region: EamA; pfam00892 573569003902 EamA-like transporter family; Region: EamA; pfam00892 573569003903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003904 putative substrate translocation pore; other site 573569003905 POT family; Region: PTR2; cl17359 573569003906 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 573569003907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003908 putative substrate translocation pore; other site 573569003909 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 573569003910 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 573569003911 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 573569003912 putative active site [active] 573569003913 putative catalytic site [active] 573569003914 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 573569003915 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 573569003916 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 573569003917 mannonate dehydratase; Provisional; Region: PRK03906 573569003918 mannonate dehydratase; Region: uxuA; TIGR00695 573569003919 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573569003920 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573569003921 substrate binding site [chemical binding]; other site 573569003922 ATP binding site [chemical binding]; other site 573569003923 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 573569003924 active site 573569003925 intersubunit interface [polypeptide binding]; other site 573569003926 catalytic residue [active] 573569003927 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 573569003928 glucuronate isomerase; Reviewed; Region: PRK02925 573569003929 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 573569003930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003931 putative substrate translocation pore; other site 573569003932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569003933 Family of unknown function (DUF706); Region: DUF706; pfam05153 573569003934 MFS/sugar transport protein; Region: MFS_2; pfam13347 573569003935 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 573569003936 catalytic motif [active] 573569003937 Catalytic residue [active] 573569003938 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 573569003939 Predicted transcriptional regulator [Transcription]; Region: COG3655 573569003940 non-specific DNA binding site [nucleotide binding]; other site 573569003941 salt bridge; other site 573569003942 sequence-specific DNA binding site [nucleotide binding]; other site 573569003943 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 573569003944 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 573569003945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573569003946 Walker A motif; other site 573569003947 ATP binding site [chemical binding]; other site 573569003948 Walker B motif; other site 573569003949 arginine finger; other site 573569003950 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 573569003951 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573569003952 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 573569003953 active site 573569003954 catalytic triad [active] 573569003955 oxyanion hole [active] 573569003956 switch loop; other site 573569003957 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 573569003958 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 573569003959 TPP-binding site; other site 573569003960 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573569003961 PYR/PP interface [polypeptide binding]; other site 573569003962 dimer interface [polypeptide binding]; other site 573569003963 TPP binding site [chemical binding]; other site 573569003964 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573569003965 GMP synthase; Reviewed; Region: guaA; PRK00074 573569003966 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 573569003967 AMP/PPi binding site [chemical binding]; other site 573569003968 candidate oxyanion hole; other site 573569003969 catalytic triad [active] 573569003970 potential glutamine specificity residues [chemical binding]; other site 573569003971 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 573569003972 ATP Binding subdomain [chemical binding]; other site 573569003973 Ligand Binding sites [chemical binding]; other site 573569003974 Dimerization subdomain; other site 573569003975 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 573569003976 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 573569003977 dimerization interface 3.5A [polypeptide binding]; other site 573569003978 active site 573569003979 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 573569003980 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 573569003981 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 573569003982 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 573569003983 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 573569003984 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 573569003985 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 573569003986 Walker A/P-loop; other site 573569003987 ATP binding site [chemical binding]; other site 573569003988 Q-loop/lid; other site 573569003989 ABC transporter signature motif; other site 573569003990 Walker B; other site 573569003991 D-loop; other site 573569003992 H-loop/switch region; other site 573569003993 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 573569003994 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 573569003995 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 573569003996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573569003997 active site 573569003998 motif I; other site 573569003999 motif II; other site 573569004000 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 573569004001 dimer interface [polypeptide binding]; other site 573569004002 substrate binding site [chemical binding]; other site 573569004003 metal binding sites [ion binding]; metal-binding site 573569004004 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 573569004005 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 573569004006 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 573569004007 Protein of unknown function (DUF493); Region: DUF493; pfam04359 573569004008 lipoate-protein ligase B; Provisional; Region: PRK14342 573569004009 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 573569004010 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 573569004011 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 573569004012 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 573569004013 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 573569004014 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573569004015 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573569004016 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573569004017 DNA binding residues [nucleotide binding] 573569004018 DNA primase; Validated; Region: dnaG; PRK05667 573569004019 CHC2 zinc finger; Region: zf-CHC2; pfam01807 573569004020 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 573569004021 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 573569004022 active site 573569004023 metal binding site [ion binding]; metal-binding site 573569004024 interdomain interaction site; other site 573569004025 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 573569004026 Yqey-like protein; Region: YqeY; pfam09424 573569004027 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 573569004028 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 573569004029 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573569004030 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573569004031 catalytic residue [active] 573569004032 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 573569004033 active site 573569004034 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 573569004035 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 573569004036 Ligand Binding Site [chemical binding]; other site 573569004037 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 573569004038 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 573569004039 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573569004040 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 573569004041 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 573569004042 substrate binding pocket [chemical binding]; other site 573569004043 chain length determination region; other site 573569004044 substrate-Mg2+ binding site; other site 573569004045 catalytic residues [active] 573569004046 aspartate-rich region 1; other site 573569004047 active site lid residues [active] 573569004048 aspartate-rich region 2; other site 573569004049 PQ loop repeat; Region: PQ-loop; pfam04193 573569004050 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573569004051 Coenzyme A binding pocket [chemical binding]; other site 573569004052 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 573569004053 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573569004054 RNA binding surface [nucleotide binding]; other site 573569004055 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 573569004056 probable active site [active] 573569004057 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573569004058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573569004059 binding surface 573569004060 TPR motif; other site 573569004061 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 573569004062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573569004063 FeS/SAM binding site; other site 573569004064 replicative DNA helicase; Region: DnaB; TIGR00665 573569004065 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 573569004066 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 573569004067 Walker A motif; other site 573569004068 ATP binding site [chemical binding]; other site 573569004069 Walker B motif; other site 573569004070 DNA binding loops [nucleotide binding] 573569004071 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 573569004072 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 573569004073 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 573569004074 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 573569004075 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 573569004076 S1 domain; Region: S1_2; pfam13509 573569004077 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 573569004078 S1 domain; Region: S1_2; pfam13509 573569004079 potential frameshift: common BLAST hit: gi|307153464|ref|YP_003888848.1| Glutathione gamma-glutamylcysteinyltransferase 573569004080 Phytochelatin synthase; Region: Phytochelatin; pfam05023 573569004081 Phytochelatin synthase; Region: Phytochelatin; pfam05023 573569004082 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 573569004083 Part of AAA domain; Region: AAA_19; pfam13245 573569004084 AAA domain; Region: AAA_14; pfam13173 573569004085 Family description; Region: UvrD_C_2; pfam13538 573569004086 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 573569004087 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 573569004088 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 573569004089 transaldolase-like protein; Provisional; Region: PTZ00411 573569004090 active site 573569004091 dimer interface [polypeptide binding]; other site 573569004092 catalytic residue [active] 573569004093 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 573569004094 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 573569004095 interface (dimer of trimers) [polypeptide binding]; other site 573569004096 Substrate-binding/catalytic site; other site 573569004097 Zn-binding sites [ion binding]; other site 573569004098 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 573569004099 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 573569004100 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 573569004101 motif 1; other site 573569004102 active site 573569004103 motif 2; other site 573569004104 motif 3; other site 573569004105 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573569004106 DHHA1 domain; Region: DHHA1; pfam02272 573569004107 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 573569004108 Part of AAA domain; Region: AAA_19; pfam13245 573569004109 Family description; Region: UvrD_C_2; pfam13538 573569004110 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 573569004111 epoxyqueuosine reductase; Region: TIGR00276 573569004112 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 573569004113 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 573569004114 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 573569004115 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 573569004116 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 573569004117 catalytic residues [active] 573569004118 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 573569004119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569004120 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 573569004121 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 573569004122 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 573569004123 TspO/MBR family; Region: TspO_MBR; pfam03073 573569004124 BCCT family transporter; Region: BCCT; pfam02028 573569004125 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 573569004126 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 573569004127 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573569004128 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 573569004129 active site 573569004130 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 573569004131 active site 573569004132 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573569004133 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 573569004134 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 573569004135 active site 573569004136 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 573569004137 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573569004138 FeS/SAM binding site; other site 573569004139 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573569004140 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 573569004141 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573569004142 nucleophilic elbow; other site 573569004143 catalytic triad; other site 573569004144 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 573569004145 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 573569004146 putative substrate binding site [chemical binding]; other site 573569004147 putative ATP binding site [chemical binding]; other site 573569004148 Putative serine esterase (DUF676); Region: DUF676; pfam05057 573569004149 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573569004150 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 573569004151 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 573569004152 active site 573569004153 Predicted integral membrane protein [Function unknown]; Region: COG5505 573569004154 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 573569004155 catalytic residues [active] 573569004156 dimer interface [polypeptide binding]; other site 573569004157 Chorismate mutase type II; Region: CM_2; smart00830 573569004158 L-aspartate oxidase; Provisional; Region: PRK09077 573569004159 L-aspartate oxidase; Provisional; Region: PRK06175 573569004160 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573569004161 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 573569004162 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 573569004163 dimerization interface [polypeptide binding]; other site 573569004164 active site 573569004165 quinolinate synthetase; Provisional; Region: PRK09375 573569004166 Guanylate kinase; Region: Guanylate_kin; pfam00625 573569004167 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 573569004168 catalytic site [active] 573569004169 G-X2-G-X-G-K; other site 573569004170 helicase 45; Provisional; Region: PTZ00424 573569004171 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573569004172 ATP binding site [chemical binding]; other site 573569004173 Mg++ binding site [ion binding]; other site 573569004174 motif III; other site 573569004175 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573569004176 nucleotide binding region [chemical binding]; other site 573569004177 ATP-binding site [chemical binding]; other site 573569004178 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 573569004179 putative RNA binding site [nucleotide binding]; other site 573569004180 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 573569004181 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 573569004182 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 573569004183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569004184 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 573569004185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569004186 putative substrate translocation pore; other site 573569004187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569004188 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 573569004189 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 573569004190 dimer interface [polypeptide binding]; other site 573569004191 active site 573569004192 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 573569004193 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 573569004194 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 573569004195 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 573569004196 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 573569004197 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 573569004198 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 573569004199 Ligand binding site; other site 573569004200 oligomer interface; other site 573569004201 Uncharacterized conserved protein [Function unknown]; Region: COG2835 573569004202 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 573569004203 CPxP motif; other site 573569004204 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 573569004205 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 573569004206 active site 573569004207 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 573569004208 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 573569004209 GIY-YIG motif/motif A; other site 573569004210 active site 573569004211 catalytic site [active] 573569004212 putative DNA binding site [nucleotide binding]; other site 573569004213 metal binding site [ion binding]; metal-binding site 573569004214 UvrB/uvrC motif; Region: UVR; pfam02151 573569004215 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 573569004216 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 573569004217 ribonuclease D; Region: rnd; TIGR01388 573569004218 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 573569004219 catalytic site [active] 573569004220 putative active site [active] 573569004221 putative substrate binding site [chemical binding]; other site 573569004222 HRDC domain; Region: HRDC; pfam00570 573569004223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569004224 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 573569004225 putative substrate translocation pore; other site 573569004226 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 573569004227 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 573569004228 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573569004229 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 573569004230 active site 573569004231 recombination protein F; Reviewed; Region: recF; PRK00064 573569004232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573569004233 Walker A/P-loop; other site 573569004234 ATP binding site [chemical binding]; other site 573569004235 Q-loop/lid; other site 573569004236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573569004237 ABC transporter signature motif; other site 573569004238 Walker B; other site 573569004239 D-loop; other site 573569004240 H-loop/switch region; other site 573569004241 EamA-like transporter family; Region: EamA; pfam00892 573569004242 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 573569004243 EamA-like transporter family; Region: EamA; pfam00892 573569004244 acetyl-CoA synthetase; Provisional; Region: PRK00174 573569004245 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 573569004246 active site 573569004247 CoA binding site [chemical binding]; other site 573569004248 acyl-activating enzyme (AAE) consensus motif; other site 573569004249 AMP binding site [chemical binding]; other site 573569004250 acetate binding site [chemical binding]; other site 573569004251 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 573569004252 active site 573569004253 tetramer interface; other site 573569004254 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 573569004255 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 573569004256 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 573569004257 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 573569004258 C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; Provisional; Region: PRK14552 573569004259 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573569004260 DNA-binding site [nucleotide binding]; DNA binding site 573569004261 RNA-binding motif; other site 573569004262 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573569004263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573569004264 FeS/SAM binding site; other site 573569004265 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 573569004266 Transcriptional regulator [Transcription]; Region: IclR; COG1414 573569004267 Bacterial transcriptional regulator; Region: IclR; pfam01614 573569004268 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 573569004269 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573569004270 HlyD family secretion protein; Region: HlyD_3; pfam13437 573569004271 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 573569004272 flavin-containing monooxygenase FMO GS-OX; Region: PLN02172 573569004273 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573569004274 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 573569004275 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573569004276 RNA binding surface [nucleotide binding]; other site 573569004277 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 573569004278 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 573569004279 active site 573569004280 HIGH motif; other site 573569004281 dimer interface [polypeptide binding]; other site 573569004282 KMSKS motif; other site 573569004283 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573569004284 RNA binding surface [nucleotide binding]; other site 573569004285 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 573569004286 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 573569004287 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 573569004288 active site 573569004289 HslU subunit interaction site [polypeptide binding]; other site 573569004290 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 573569004291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573569004292 Walker A motif; other site 573569004293 ATP binding site [chemical binding]; other site 573569004294 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 573569004295 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573569004296 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 573569004297 POT family; Region: PTR2; cl17359 573569004298 Ion transport protein; Region: Ion_trans; pfam00520 573569004299 Ion channel; Region: Ion_trans_2; pfam07885 573569004300 TrkA-N domain; Region: TrkA_N; pfam02254 573569004301 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 573569004302 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573569004303 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573569004304 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 573569004305 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 573569004306 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 573569004307 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 573569004308 dimerization domain [polypeptide binding]; other site 573569004309 dimer interface [polypeptide binding]; other site 573569004310 catalytic residues [active] 573569004311 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 573569004312 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 573569004313 putative active site [active] 573569004314 catalytic residue [active] 573569004315 GTP-binding protein YchF; Reviewed; Region: PRK09601 573569004316 YchF GTPase; Region: YchF; cd01900 573569004317 G1 box; other site 573569004318 GTP/Mg2+ binding site [chemical binding]; other site 573569004319 Switch I region; other site 573569004320 G2 box; other site 573569004321 Switch II region; other site 573569004322 G3 box; other site 573569004323 G4 box; other site 573569004324 G5 box; other site 573569004325 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 573569004326 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 573569004327 Domain of unknown function DUF21; Region: DUF21; pfam01595 573569004328 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573569004329 Transporter associated domain; Region: CorC_HlyC; pfam03471 573569004330 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 573569004331 5S rRNA interface [nucleotide binding]; other site 573569004332 CTC domain interface [polypeptide binding]; other site 573569004333 L16 interface [polypeptide binding]; other site 573569004334 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 573569004335 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 573569004336 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573569004337 active site 573569004338 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 573569004339 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 573569004340 putative active site [active] 573569004341 Zn binding site [ion binding]; other site 573569004342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569004343 putative substrate translocation pore; other site 573569004344 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573569004345 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573569004346 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573569004347 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 573569004348 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 573569004349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 573569004350 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 573569004351 RmuC family; Region: RmuC; pfam02646 573569004352 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 573569004353 RuvA N terminal domain; Region: RuvA_N; pfam01330 573569004354 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 573569004355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569004356 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573569004357 putative substrate translocation pore; other site 573569004358 potential frameshift: common BLAST hit: gi|289164543|ref|YP_003454681.1| transcription regulators (MerR Family) 573569004359 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 573569004360 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573569004361 DNA binding residues [nucleotide binding] 573569004362 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 573569004363 active site 573569004364 putative DNA-binding cleft [nucleotide binding]; other site 573569004365 dimer interface [polypeptide binding]; other site 573569004366 hypothetical protein; Validated; Region: PRK00110 573569004367 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 573569004368 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 573569004369 conserved cys residue [active] 573569004370 lipoyl synthase; Provisional; Region: PRK05481 573569004371 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573569004372 FeS/SAM binding site; other site 573569004373 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 573569004374 Ferritin-like domain; Region: Ferritin; pfam00210 573569004375 ferroxidase diiron center [ion binding]; other site 573569004376 POT family; Region: PTR2; cl17359 573569004377 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 573569004378 Patatin-like phospholipase; Region: Patatin; pfam01734 573569004379 nucleophile elbow; other site 573569004380 glutaredoxin 2; Provisional; Region: PRK10387 573569004381 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573569004382 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 573569004383 N-terminal domain interface [polypeptide binding]; other site 573569004384 ferredoxin; Provisional; Region: PRK08764 573569004385 Putative Fe-S cluster; Region: FeS; cl17515 573569004386 4Fe-4S binding domain; Region: Fer4; pfam00037 573569004387 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 573569004388 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573569004389 minor groove reading motif; other site 573569004390 helix-hairpin-helix signature motif; other site 573569004391 substrate binding pocket [chemical binding]; other site 573569004392 active site 573569004393 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 573569004394 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 573569004395 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 573569004396 YccA-like proteins; Region: YccA_like; cd10433 573569004397 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 573569004398 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 573569004399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573569004400 ATP binding site [chemical binding]; other site 573569004401 putative Mg++ binding site [ion binding]; other site 573569004402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573569004403 nucleotide binding region [chemical binding]; other site 573569004404 ATP-binding site [chemical binding]; other site 573569004405 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 573569004406 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 573569004407 putative valine binding site [chemical binding]; other site 573569004408 dimer interface [polypeptide binding]; other site 573569004409 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 573569004410 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573569004411 PYR/PP interface [polypeptide binding]; other site 573569004412 dimer interface [polypeptide binding]; other site 573569004413 TPP binding site [chemical binding]; other site 573569004414 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573569004415 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 573569004416 TPP-binding site [chemical binding]; other site 573569004417 dimer interface [polypeptide binding]; other site 573569004418 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 573569004419 threonine synthase; Reviewed; Region: PRK06721 573569004420 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 573569004421 homodimer interface [polypeptide binding]; other site 573569004422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569004423 catalytic residue [active] 573569004424 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 573569004425 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 573569004426 G1 box; other site 573569004427 GTP/Mg2+ binding site [chemical binding]; other site 573569004428 Switch I region; other site 573569004429 G2 box; other site 573569004430 G3 box; other site 573569004431 Switch II region; other site 573569004432 G4 box; other site 573569004433 G5 box; other site 573569004434 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 573569004435 Low molecular weight phosphatase family; Region: LMWPc; cd00115 573569004436 active site 573569004437 FtsH protease regulator HflC; Provisional; Region: PRK11029 573569004438 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 573569004439 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 573569004440 HflK protein; Region: hflK; TIGR01933 573569004441 hypothetical protein; Provisional; Region: PRK07588 573569004442 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 573569004443 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 573569004444 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 573569004445 HflX GTPase family; Region: HflX; cd01878 573569004446 G1 box; other site 573569004447 GTP/Mg2+ binding site [chemical binding]; other site 573569004448 Switch I region; other site 573569004449 G2 box; other site 573569004450 G3 box; other site 573569004451 Switch II region; other site 573569004452 G4 box; other site 573569004453 G5 box; other site 573569004454 bacterial Hfq-like; Region: Hfq; cd01716 573569004455 hexamer interface [polypeptide binding]; other site 573569004456 Sm1 motif; other site 573569004457 RNA binding site [nucleotide binding]; other site 573569004458 Sm2 motif; other site 573569004459 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 573569004460 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 573569004461 SurA N-terminal domain; Region: SurA_N_3; cl07813 573569004462 periplasmic folding chaperone; Provisional; Region: PRK10788 573569004463 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 573569004464 IHF dimer interface [polypeptide binding]; other site 573569004465 IHF - DNA interface [nucleotide binding]; other site 573569004466 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 573569004467 Found in ATP-dependent protease La (LON); Region: LON; smart00464 573569004468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573569004469 Walker A motif; other site 573569004470 ATP binding site [chemical binding]; other site 573569004471 Walker B motif; other site 573569004472 arginine finger; other site 573569004473 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573569004474 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 573569004475 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 573569004476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573569004477 Walker A motif; other site 573569004478 ATP binding site [chemical binding]; other site 573569004479 Walker B motif; other site 573569004480 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573569004481 Clp protease; Region: CLP_protease; pfam00574 573569004482 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 573569004483 oligomer interface [polypeptide binding]; other site 573569004484 active site residues [active] 573569004485 trigger factor; Provisional; Region: tig; PRK01490 573569004486 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573569004487 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 573569004488 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 573569004489 active site clefts [active] 573569004490 zinc binding site [ion binding]; other site 573569004491 dimer interface [polypeptide binding]; other site 573569004492 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 573569004493 active site 573569004494 homodimer interface [polypeptide binding]; other site 573569004495 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 573569004496 RNA/DNA hybrid binding site [nucleotide binding]; other site 573569004497 active site 573569004498 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 573569004499 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 573569004500 hinge; other site 573569004501 active site 573569004502 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 573569004503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573569004504 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573569004505 DNA binding residues [nucleotide binding] 573569004506 Bacterial SH3 domain; Region: SH3_3; cl17532 573569004507 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 573569004508 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 573569004509 Protein export membrane protein; Region: SecD_SecF; pfam02355 573569004510 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 573569004511 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 573569004512 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 573569004513 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 573569004514 putative transporter; Provisional; Region: PRK03699 573569004515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569004516 putative substrate translocation pore; other site 573569004517 Isochorismatase family; Region: Isochorismatase; pfam00857 573569004518 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 573569004519 catalytic triad [active] 573569004520 conserved cis-peptide bond; other site 573569004521 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 573569004522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573569004523 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573569004524 dimerization interface [polypeptide binding]; other site 573569004525 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 573569004526 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 573569004527 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 573569004528 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 573569004529 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 573569004530 Walker A/P-loop; other site 573569004531 ATP binding site [chemical binding]; other site 573569004532 Q-loop/lid; other site 573569004533 ABC transporter signature motif; other site 573569004534 Walker B; other site 573569004535 D-loop; other site 573569004536 H-loop/switch region; other site 573569004537 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 573569004538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573569004539 dimer interface [polypeptide binding]; other site 573569004540 conserved gate region; other site 573569004541 ABC-ATPase subunit interface; other site 573569004542 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 573569004543 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 573569004544 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 573569004545 aromatic amino acid transport protein; Region: araaP; TIGR00837 573569004546 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573569004547 active site residue [active] 573569004548 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573569004549 active site residue [active] 573569004550 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 573569004551 homotrimer interaction site [polypeptide binding]; other site 573569004552 zinc binding site [ion binding]; other site 573569004553 CDP-binding sites; other site 573569004554 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573569004555 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573569004556 cyanophycin synthetase; Provisional; Region: PRK14016 573569004557 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573569004558 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573569004559 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573569004560 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 573569004561 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 573569004562 putative MPT binding site; other site 573569004563 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 573569004564 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 573569004565 active site 573569004566 catalytic site [active] 573569004567 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 573569004568 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 573569004569 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 573569004570 Walker A motif; other site 573569004571 ATP binding site [chemical binding]; other site 573569004572 Walker B motif; other site 573569004573 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 573569004574 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 573569004575 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 573569004576 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573569004577 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573569004578 ligand binding site [chemical binding]; other site 573569004579 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573569004580 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 573569004581 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 573569004582 active site 573569004583 (T/H)XGH motif; other site 573569004584 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 573569004585 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 573569004586 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 573569004587 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 573569004588 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573569004589 catalytic residue [active] 573569004590 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 573569004591 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 573569004592 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 573569004593 Protein of unknown function DUF45; Region: DUF45; pfam01863 573569004594 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 573569004595 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 573569004596 active site 573569004597 metal binding site [ion binding]; metal-binding site 573569004598 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 573569004599 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 573569004600 Prephenate dehydratase; Region: PDT; pfam00800 573569004601 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 573569004602 putative L-Phe binding site [chemical binding]; other site 573569004603 amino acid transporter; Region: 2A0306; TIGR00909 573569004604 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 573569004605 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 573569004606 active site 573569004607 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573569004608 dimer interface [polypeptide binding]; other site 573569004609 substrate binding site [chemical binding]; other site 573569004610 catalytic residues [active] 573569004611 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 573569004612 POT family; Region: PTR2; cl17359 573569004613 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 573569004614 putative C-terminal domain interface [polypeptide binding]; other site 573569004615 putative GSH binding site [chemical binding]; other site 573569004616 putative dimer interface [polypeptide binding]; other site 573569004617 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 573569004618 putative N-terminal domain interface [polypeptide binding]; other site 573569004619 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 573569004620 hypothetical protein; Provisional; Region: PRK14013 573569004621 phosphoserine phosphatase SerB; Region: serB; TIGR00338 573569004622 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 573569004623 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 573569004624 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 573569004625 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 573569004626 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573569004627 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 573569004628 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 573569004629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573569004630 Walker A/P-loop; other site 573569004631 ATP binding site [chemical binding]; other site 573569004632 Q-loop/lid; other site 573569004633 ABC transporter signature motif; other site 573569004634 Walker B; other site 573569004635 D-loop; other site 573569004636 H-loop/switch region; other site 573569004637 TOBE domain; Region: TOBE_2; pfam08402 573569004638 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573569004639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573569004640 dimer interface [polypeptide binding]; other site 573569004641 conserved gate region; other site 573569004642 putative PBP binding loops; other site 573569004643 ABC-ATPase subunit interface; other site 573569004644 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 573569004645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573569004646 dimer interface [polypeptide binding]; other site 573569004647 conserved gate region; other site 573569004648 putative PBP binding loops; other site 573569004649 ABC-ATPase subunit interface; other site 573569004650 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 573569004651 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 573569004652 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 573569004653 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 573569004654 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 573569004655 DEAD/DEAH box helicase; Region: DEAD; pfam00270 573569004656 ATP binding site [chemical binding]; other site 573569004657 putative Mg++ binding site [ion binding]; other site 573569004658 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 573569004659 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 573569004660 nucleotide binding region [chemical binding]; other site 573569004661 ATP-binding site [chemical binding]; other site 573569004662 SEC-C motif; Region: SEC-C; pfam02810 573569004663 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cl12263 573569004664 LPP20 lipoprotein; Region: LPP20; pfam02169 573569004665 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 573569004666 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 573569004667 FtsH Extracellular; Region: FtsH_ext; pfam06480 573569004668 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 573569004669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573569004670 Walker A motif; other site 573569004671 ATP binding site [chemical binding]; other site 573569004672 Walker B motif; other site 573569004673 arginine finger; other site 573569004674 Peptidase family M41; Region: Peptidase_M41; pfam01434 573569004675 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 573569004676 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 573569004677 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 573569004678 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 573569004679 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 573569004680 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 573569004681 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 573569004682 Type II transport protein GspH; Region: GspH; pfam12019 573569004683 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 573569004684 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 573569004685 active site 573569004686 dimer interface [polypeptide binding]; other site 573569004687 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 573569004688 dimer interface [polypeptide binding]; other site 573569004689 active site 573569004690 Thiamine pyrophosphokinase; Region: TPK; cd07995 573569004691 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 573569004692 active site 573569004693 dimerization interface [polypeptide binding]; other site 573569004694 thiamine binding site [chemical binding]; other site 573569004695 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 573569004696 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573569004697 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 573569004698 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 573569004699 active site 573569004700 multifunctional aminopeptidase A; Provisional; Region: PRK00913 573569004701 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 573569004702 interface (dimer of trimers) [polypeptide binding]; other site 573569004703 Substrate-binding/catalytic site; other site 573569004704 Zn-binding sites [ion binding]; other site 573569004705 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 573569004706 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 573569004707 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 573569004708 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 573569004709 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573569004710 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573569004711 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573569004712 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573569004713 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573569004714 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 573569004715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569004716 S-adenosylmethionine binding site [chemical binding]; other site 573569004717 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573569004718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573569004719 LysR substrate binding domain; Region: LysR_substrate; pfam03466 573569004720 dimerization interface [polypeptide binding]; other site 573569004721 hypothetical protein; Provisional; Region: PRK06062 573569004722 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573569004723 inhibitor-cofactor binding pocket; inhibition site 573569004724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569004725 catalytic residue [active] 573569004726 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 573569004727 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 573569004728 tetrameric interface [polypeptide binding]; other site 573569004729 NAD binding site [chemical binding]; other site 573569004730 catalytic residues [active] 573569004731 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 573569004732 Predicted membrane protein [Function unknown]; Region: COG2860 573569004733 UPF0126 domain; Region: UPF0126; pfam03458 573569004734 UPF0126 domain; Region: UPF0126; pfam03458 573569004735 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 573569004736 active site 573569004737 dinuclear metal binding site [ion binding]; other site 573569004738 dimerization interface [polypeptide binding]; other site 573569004739 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 573569004740 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 573569004741 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 573569004742 active site 573569004743 catalytic motif [active] 573569004744 Zn binding site [ion binding]; other site 573569004745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569004746 putative substrate translocation pore; other site 573569004747 POT family; Region: PTR2; cl17359 573569004748 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 573569004749 FAD binding domain; Region: FAD_binding_4; pfam01565 573569004750 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 573569004751 phosphoglyceromutase; Provisional; Region: PRK05434 573569004752 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 573569004753 seryl-tRNA synthetase; Provisional; Region: PRK05431 573569004754 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 573569004755 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 573569004756 dimer interface [polypeptide binding]; other site 573569004757 active site 573569004758 motif 1; other site 573569004759 motif 2; other site 573569004760 motif 3; other site 573569004761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 573569004762 Predicted membrane protein [Function unknown]; Region: COG4325 573569004763 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 573569004764 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573569004765 ROK family; Region: ROK; pfam00480 573569004766 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 573569004767 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 573569004768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573569004769 Walker A/P-loop; other site 573569004770 ATP binding site [chemical binding]; other site 573569004771 Q-loop/lid; other site 573569004772 ABC transporter signature motif; other site 573569004773 Walker B; other site 573569004774 D-loop; other site 573569004775 H-loop/switch region; other site 573569004776 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 573569004777 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573569004778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573569004779 Walker A/P-loop; other site 573569004780 ATP binding site [chemical binding]; other site 573569004781 Q-loop/lid; other site 573569004782 ABC transporter signature motif; other site 573569004783 Walker B; other site 573569004784 D-loop; other site 573569004785 H-loop/switch region; other site 573569004786 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 573569004787 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 573569004788 MAPEG family; Region: MAPEG; pfam01124 573569004789 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 573569004790 homotrimer interaction site [polypeptide binding]; other site 573569004791 putative active site [active] 573569004792 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 573569004793 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 573569004794 Sulfate transporter family; Region: Sulfate_transp; pfam00916 573569004795 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 573569004796 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 573569004797 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 573569004798 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 573569004799 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573569004800 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573569004801 Walker A/P-loop; other site 573569004802 ATP binding site [chemical binding]; other site 573569004803 Q-loop/lid; other site 573569004804 ABC transporter signature motif; other site 573569004805 Walker B; other site 573569004806 D-loop; other site 573569004807 H-loop/switch region; other site 573569004808 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573569004809 HlyD family secretion protein; Region: HlyD_3; pfam13437 573569004810 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 573569004811 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 573569004812 active site 573569004813 catalytic site [active] 573569004814 metal binding site [ion binding]; metal-binding site 573569004815 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 573569004816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569004817 putative substrate translocation pore; other site 573569004818 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 573569004819 glucose-1-dehydrogenase; Provisional; Region: PRK06947 573569004820 classical (c) SDRs; Region: SDR_c; cd05233 573569004821 NAD(P) binding site [chemical binding]; other site 573569004822 active site 573569004823 Type II transport protein GspH; Region: GspH; pfam12019 573569004824 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 573569004825 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 573569004826 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 573569004827 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 573569004828 heme binding site [chemical binding]; other site 573569004829 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 573569004830 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 573569004831 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573569004832 Zn2+ binding site [ion binding]; other site 573569004833 Mg2+ binding site [ion binding]; other site 573569004834 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 573569004835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569004836 metabolite-proton symporter; Region: 2A0106; TIGR00883 573569004837 putative substrate translocation pore; other site 573569004838 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 573569004839 putative substrate binding pocket [chemical binding]; other site 573569004840 trimer interface [polypeptide binding]; other site 573569004841 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 573569004842 putative efflux protein, MATE family; Region: matE; TIGR00797 573569004843 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 573569004844 aromatic chitin/cellulose binding site residues [chemical binding]; other site 573569004845 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cd00598 573569004846 active site 573569004847 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 573569004848 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 573569004849 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 573569004850 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 573569004851 putative active site [active] 573569004852 putative substrate binding site [chemical binding]; other site 573569004853 putative cosubstrate binding site; other site 573569004854 catalytic site [active] 573569004855 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573569004856 active site 573569004857 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 573569004858 aromatic chitin/cellulose binding site residues [chemical binding]; other site 573569004859 Glyco_18 domain; Region: Glyco_18; smart00636 573569004860 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 573569004861 active site 573569004862 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 573569004863 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 573569004864 substrate-cofactor binding pocket; other site 573569004865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569004866 catalytic residue [active] 573569004867 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 573569004868 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 573569004869 NAD(P) binding site [chemical binding]; other site 573569004870 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 573569004871 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 573569004872 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 573569004873 substrate binding site; other site 573569004874 dimer interface; other site 573569004875 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 573569004876 Septum formation initiator; Region: DivIC; cl17659 573569004877 enolase; Provisional; Region: eno; PRK00077 573569004878 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 573569004879 dimer interface [polypeptide binding]; other site 573569004880 metal binding site [ion binding]; metal-binding site 573569004881 substrate binding pocket [chemical binding]; other site 573569004882 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573569004883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569004884 putative substrate translocation pore; other site 573569004885 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 573569004886 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573569004887 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573569004888 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573569004889 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573569004890 nucleotide binding site [chemical binding]; other site 573569004891 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573569004892 TRAM domain; Region: TRAM; cl01282 573569004893 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 573569004894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569004895 S-adenosylmethionine binding site [chemical binding]; other site 573569004896 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 573569004897 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 573569004898 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 573569004899 ATP-binding site [chemical binding]; other site 573569004900 Sugar specificity; other site 573569004901 Pyrimidine base specificity; other site 573569004902 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 573569004903 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 573569004904 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 573569004905 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 573569004906 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 573569004907 oligomer interface [polypeptide binding]; other site 573569004908 RNA binding site [nucleotide binding]; other site 573569004909 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 573569004910 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 573569004911 RNase E interface [polypeptide binding]; other site 573569004912 trimer interface [polypeptide binding]; other site 573569004913 active site 573569004914 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 573569004915 putative nucleic acid binding region [nucleotide binding]; other site 573569004916 G-X-X-G motif; other site 573569004917 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573569004918 RNA binding site [nucleotide binding]; other site 573569004919 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 573569004920 16S/18S rRNA binding site [nucleotide binding]; other site 573569004921 S13e-L30e interaction site [polypeptide binding]; other site 573569004922 25S rRNA binding site [nucleotide binding]; other site 573569004923 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 573569004924 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573569004925 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573569004926 Cell division protein FtsL; Region: FtsL; cl11433 573569004927 MraW methylase family; Region: Methyltransf_5; cl17771 573569004928 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 573569004929 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 573569004930 AMP-binding enzyme; Region: AMP-binding; pfam00501 573569004931 acyl-activating enzyme (AAE) consensus motif; other site 573569004932 putative AMP binding site [chemical binding]; other site 573569004933 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 573569004934 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 573569004935 DNA binding site [nucleotide binding] 573569004936 catalytic residue [active] 573569004937 H2TH interface [polypeptide binding]; other site 573569004938 putative catalytic residues [active] 573569004939 turnover-facilitating residue; other site 573569004940 intercalation triad [nucleotide binding]; other site 573569004941 8OG recognition residue [nucleotide binding]; other site 573569004942 putative reading head residues; other site 573569004943 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 573569004944 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 573569004945 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 573569004946 predicted active site [active] 573569004947 catalytic triad [active] 573569004948 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 573569004949 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 573569004950 active site 573569004951 multimer interface [polypeptide binding]; other site 573569004952 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 573569004953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573569004954 ATP binding site [chemical binding]; other site 573569004955 Mg2+ binding site [ion binding]; other site 573569004956 G-X-G motif; other site 573569004957 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 573569004958 anchoring element; other site 573569004959 dimer interface [polypeptide binding]; other site 573569004960 ATP binding site [chemical binding]; other site 573569004961 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 573569004962 active site 573569004963 putative metal-binding site [ion binding]; other site 573569004964 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 573569004965 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 573569004966 putative active site pocket [active] 573569004967 dimerization interface [polypeptide binding]; other site 573569004968 putative catalytic residue [active] 573569004969 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 573569004970 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 573569004971 FMN binding site [chemical binding]; other site 573569004972 active site 573569004973 catalytic residues [active] 573569004974 substrate binding site [chemical binding]; other site 573569004975 TIGR03546 family protein; Region: TIGR03546 573569004976 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 573569004977 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 573569004978 CoA-ligase; Region: Ligase_CoA; pfam00549 573569004979 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 573569004980 CoA binding domain; Region: CoA_binding; smart00881 573569004981 CoA-ligase; Region: Ligase_CoA; pfam00549 573569004982 C factor cell-cell signaling protein; Provisional; Region: PRK09009 573569004983 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 573569004984 NADP binding site [chemical binding]; other site 573569004985 homodimer interface [polypeptide binding]; other site 573569004986 active site 573569004987 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 573569004988 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 573569004989 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 573569004990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569004991 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 573569004992 active site 573569004993 dimer interface [polypeptide binding]; other site 573569004994 catalytic nucleophile [active] 573569004995 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 573569004996 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 573569004997 CutC family; Region: CutC; cl01218 573569004998 phosphoglycolate phosphatase; Provisional; Region: PRK13222 573569004999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573569005000 motif II; other site 573569005001 thioredoxin reductase; Provisional; Region: PRK10262 573569005002 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573569005003 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573569005004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569005005 putative substrate translocation pore; other site 573569005006 H+ Antiporter protein; Region: 2A0121; TIGR00900 573569005007 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 573569005008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573569005009 ATP binding site [chemical binding]; other site 573569005010 Mg2+ binding site [ion binding]; other site 573569005011 G-X-G motif; other site 573569005012 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 573569005013 ATP binding site [chemical binding]; other site 573569005014 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 573569005015 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 573569005016 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 573569005017 GTPase RsgA; Reviewed; Region: PRK00098 573569005018 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573569005019 RNA binding site [nucleotide binding]; other site 573569005020 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 573569005021 GTPase/Zn-binding domain interface [polypeptide binding]; other site 573569005022 GTP/Mg2+ binding site [chemical binding]; other site 573569005023 G4 box; other site 573569005024 G5 box; other site 573569005025 G1 box; other site 573569005026 Switch I region; other site 573569005027 G2 box; other site 573569005028 G3 box; other site 573569005029 Switch II region; other site 573569005030 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 573569005031 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573569005032 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 573569005033 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 573569005034 Domain of unknown function DUF20; Region: UPF0118; pfam01594 573569005035 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 573569005036 DHH family; Region: DHH; pfam01368 573569005037 DHHA1 domain; Region: DHHA1; pfam02272 573569005038 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 573569005039 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 573569005040 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573569005041 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 573569005042 motif 1; other site 573569005043 dimer interface [polypeptide binding]; other site 573569005044 active site 573569005045 motif 2; other site 573569005046 motif 3; other site 573569005047 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573569005048 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573569005049 Helix-turn-helix domain; Region: HTH_25; pfam13413 573569005050 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 573569005051 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573569005052 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 573569005053 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 573569005054 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 573569005055 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 573569005056 carboxyltransferase (CT) interaction site; other site 573569005057 biotinylation site [posttranslational modification]; other site 573569005058 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 573569005059 Dehydroquinase class II; Region: DHquinase_II; pfam01220 573569005060 active site 573569005061 trimer interface [polypeptide binding]; other site 573569005062 dimer interface [polypeptide binding]; other site 573569005063 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 573569005064 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 573569005065 active site 573569005066 metal binding site [ion binding]; metal-binding site 573569005067 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 573569005068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573569005069 S-adenosylmethionine binding site [chemical binding]; other site 573569005070 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 573569005071 SurA N-terminal domain; Region: SurA_N; pfam09312 573569005072 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 573569005073 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 573569005074 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 573569005075 OstA-like protein; Region: OstA; cl00844 573569005076 Organic solvent tolerance protein; Region: OstA_C; pfam04453 573569005077 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 573569005078 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 573569005079 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573569005080 active site 573569005081 HIGH motif; other site 573569005082 nucleotide binding site [chemical binding]; other site 573569005083 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 573569005084 KMSK motif region; other site 573569005085 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573569005086 tRNA binding surface [nucleotide binding]; other site 573569005087 anticodon binding site; other site 573569005088 POT family; Region: PTR2; cl17359 573569005089 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 573569005090 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 573569005091 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 573569005092 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 573569005093 DNA polymerase III subunit delta'; Validated; Region: PRK08485 573569005094 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 573569005095 putative inner membrane peptidase; Provisional; Region: PRK11778 573569005096 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 573569005097 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 573569005098 tandem repeat interface [polypeptide binding]; other site 573569005099 oligomer interface [polypeptide binding]; other site 573569005100 active site residues [active] 573569005101 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 573569005102 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573569005103 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 573569005104 dimer interface [polypeptide binding]; other site 573569005105 N-terminal domain interface [polypeptide binding]; other site 573569005106 DsrC like protein; Region: DsrC; pfam04358 573569005107 oxidative damage protection protein; Provisional; Region: PRK05408 573569005108 cell division protein FtsW; Region: ftsW; TIGR02614 573569005109 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 573569005110 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573569005111 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573569005112 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 573569005113 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 573569005114 Mg++ binding site [ion binding]; other site 573569005115 putative catalytic motif [active] 573569005116 putative substrate binding site [chemical binding]; other site 573569005117 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 573569005118 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 573569005119 active site 573569005120 metal-binding site [ion binding] 573569005121 nucleotide-binding site [chemical binding]; other site 573569005122 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 573569005123 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573569005124 active site 573569005125 HIGH motif; other site 573569005126 nucleotide binding site [chemical binding]; other site 573569005127 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 573569005128 KMSKS motif; other site 573569005129 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 573569005130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569005131 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 573569005132 putative substrate translocation pore; other site 573569005133 ABC transporter ATPase component; Reviewed; Region: PRK11147 573569005134 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573569005135 Walker A/P-loop; other site 573569005136 ATP binding site [chemical binding]; other site 573569005137 Q-loop/lid; other site 573569005138 ABC transporter signature motif; other site 573569005139 Walker B; other site 573569005140 D-loop; other site 573569005141 H-loop/switch region; other site 573569005142 ABC transporter; Region: ABC_tran_2; pfam12848 573569005143 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573569005144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569005145 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573569005146 putative substrate translocation pore; other site 573569005147 Predicted membrane protein [Function unknown]; Region: COG4129 573569005148 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 573569005149 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 573569005150 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 573569005151 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573569005152 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 573569005153 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573569005154 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573569005155 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573569005156 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573569005157 active site 573569005158 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 573569005159 putative active site [active] 573569005160 putative metal binding site [ion binding]; other site 573569005161 threonine synthase; Validated; Region: PRK09225 573569005162 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 573569005163 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573569005164 catalytic residue [active] 573569005165 homoserine kinase; Provisional; Region: PRK01212 573569005166 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 573569005167 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 573569005168 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 573569005169 nucleotide binding site [chemical binding]; other site 573569005170 substrate binding site [chemical binding]; other site 573569005171 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 573569005172 dimer interface [polypeptide binding]; other site 573569005173 putative threonine allosteric regulatory site; other site 573569005174 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 573569005175 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 573569005176 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 573569005177 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 573569005178 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573569005179 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 573569005180 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573569005181 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573569005182 HD domain; Region: HD_3; pfam13023 573569005183 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573569005184 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 573569005185 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573569005186 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573569005187 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 573569005188 dimer interface [polypeptide binding]; other site 573569005189 motif 1; other site 573569005190 active site 573569005191 motif 2; other site 573569005192 motif 3; other site 573569005193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573569005194 Coenzyme A binding pocket [chemical binding]; other site 573569005195 4-alpha-glucanotransferase; Provisional; Region: PRK14508 573569005196 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573569005197 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 573569005198 glycogen synthase; Provisional; Region: glgA; PRK00654 573569005199 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 573569005200 ADP-binding pocket [chemical binding]; other site 573569005201 homodimer interface [polypeptide binding]; other site 573569005202 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 573569005203 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 573569005204 ligand binding site; other site 573569005205 oligomer interface; other site 573569005206 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 573569005207 dimer interface [polypeptide binding]; other site 573569005208 N-terminal domain interface [polypeptide binding]; other site 573569005209 sulfate 1 binding site; other site 573569005210 phosphoglucomutase; Region: PLN02307 573569005211 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 573569005212 substrate binding site [chemical binding]; other site 573569005213 dimer interface [polypeptide binding]; other site 573569005214 active site 573569005215 metal binding site [ion binding]; metal-binding site 573569005216 glycogen branching enzyme; Provisional; Region: PRK12313 573569005217 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 573569005218 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 573569005219 active site 573569005220 catalytic site [active] 573569005221 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 573569005222 pullulanase, type I; Region: pulA_typeI; TIGR02104 573569005223 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 573569005224 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 573569005225 Ca binding site [ion binding]; other site 573569005226 active site 573569005227 catalytic site [active] 573569005228 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 573569005229 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 573569005230 shikimate binding site; other site 573569005231 NAD(P) binding site [chemical binding]; other site 573569005232 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 573569005233 conserved cys residue [active] 573569005234 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 573569005235 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573569005236 homodimer interface [polypeptide binding]; other site 573569005237 substrate-cofactor binding pocket; other site 573569005238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569005239 catalytic residue [active] 573569005240 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 573569005241 active site 573569005242 catalytic triad [active] 573569005243 oxyanion hole [active] 573569005244 CAAX protease self-immunity; Region: Abi; pfam02517 573569005245 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 573569005246 tetramer interface [polypeptide binding]; other site 573569005247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569005248 catalytic residue [active] 573569005249 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 573569005250 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 573569005251 tetramer interface [polypeptide binding]; other site 573569005252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569005253 catalytic residue [active] 573569005254 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 573569005255 lipoyl attachment site [posttranslational modification]; other site 573569005256 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 573569005257 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 573569005258 lysine decarboxylase LdcC; Provisional; Region: PRK15399 573569005259 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 573569005260 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 573569005261 homodimer interface [polypeptide binding]; other site 573569005262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569005263 catalytic residue [active] 573569005264 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 573569005265 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 573569005266 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573569005267 Walker A/P-loop; other site 573569005268 ATP binding site [chemical binding]; other site 573569005269 Q-loop/lid; other site 573569005270 ABC transporter signature motif; other site 573569005271 Walker B; other site 573569005272 D-loop; other site 573569005273 H-loop/switch region; other site 573569005274 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 573569005275 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573569005276 FtsX-like permease family; Region: FtsX; pfam02687 573569005277 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 573569005278 active site 573569005279 catalytic residues [active] 573569005280 metal binding site [ion binding]; metal-binding site 573569005281 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573569005282 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 573569005283 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 573569005284 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 573569005285 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 573569005286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 573569005287 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 573569005288 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 573569005289 GIY-YIG motif/motif A; other site 573569005290 putative active site [active] 573569005291 putative metal binding site [ion binding]; other site 573569005292 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 573569005293 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 573569005294 putative active site [active] 573569005295 putative PHP Thumb interface [polypeptide binding]; other site 573569005296 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573569005297 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573569005298 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 573569005299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569005300 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573569005301 putative substrate translocation pore; other site 573569005302 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573569005303 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573569005304 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573569005305 catalytic residue [active] 573569005306 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 573569005307 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 573569005308 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 573569005309 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 573569005310 CAP-like domain; other site 573569005311 active site 573569005312 primary dimer interface [polypeptide binding]; other site 573569005313 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 573569005314 active site 573569005315 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 573569005316 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573569005317 dimerization interface [polypeptide binding]; other site 573569005318 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 573569005319 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 573569005320 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 573569005321 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 573569005322 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 573569005323 metal binding site [ion binding]; metal-binding site 573569005324 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573569005325 DNA-binding site [nucleotide binding]; DNA binding site 573569005326 RNA-binding motif; other site 573569005327 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 573569005328 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573569005329 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 573569005330 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 573569005331 glutaminase active site [active] 573569005332 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 573569005333 dimer interface [polypeptide binding]; other site 573569005334 active site 573569005335 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 573569005336 dimer interface [polypeptide binding]; other site 573569005337 active site 573569005338 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 573569005339 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 573569005340 Substrate binding site; other site 573569005341 Mg++ binding site; other site 573569005342 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 573569005343 active site 573569005344 substrate binding site [chemical binding]; other site 573569005345 CoA binding site [chemical binding]; other site 573569005346 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 573569005347 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573569005348 active site 573569005349 nucleotide binding site [chemical binding]; other site 573569005350 HIGH motif; other site 573569005351 KMSKS motif; other site 573569005352 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 573569005353 nudix motif; other site 573569005354 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 573569005355 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 573569005356 Peptidase family M50; Region: Peptidase_M50; pfam02163 573569005357 active site 573569005358 putative substrate binding region [chemical binding]; other site 573569005359 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 573569005360 aspartate aminotransferase; Provisional; Region: PRK05764 573569005361 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573569005362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569005363 homodimer interface [polypeptide binding]; other site 573569005364 catalytic residue [active] 573569005365 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 573569005366 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810 573569005367 active site 573569005368 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573569005369 dimer interface [polypeptide binding]; other site 573569005370 catalytic residues [active] 573569005371 substrate binding site [chemical binding]; other site 573569005372 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 573569005373 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 573569005374 trimer interface [polypeptide binding]; other site 573569005375 active site 573569005376 substrate binding site [chemical binding]; other site 573569005377 CoA binding site [chemical binding]; other site 573569005378 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 573569005379 dihydrodipicolinate synthase; Region: dapA; TIGR00674 573569005380 dimer interface [polypeptide binding]; other site 573569005381 active site 573569005382 catalytic residue [active] 573569005383 dihydrodipicolinate reductase; Provisional; Region: PRK00048 573569005384 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 573569005385 Peptidase family C1 propeptide; Region: Propeptide_C1; pfam08127 573569005386 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 573569005387 aspartate kinase III; Validated; Region: PRK09084 573569005388 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 573569005389 nucleotide binding site [chemical binding]; other site 573569005390 substrate binding site [chemical binding]; other site 573569005391 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 573569005392 lysine allosteric regulatory site; other site 573569005393 dimer interface [polypeptide binding]; other site 573569005394 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 573569005395 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 573569005396 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573569005397 active site 573569005398 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 573569005399 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 573569005400 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 573569005401 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 573569005402 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 573569005403 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 573569005404 Cl- selectivity filter; other site 573569005405 Cl- binding residues [ion binding]; other site 573569005406 pore gating glutamate residue; other site 573569005407 dimer interface [polypeptide binding]; other site 573569005408 H+/Cl- coupling transport residue; other site 573569005409 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 573569005410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 573569005411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573569005412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573569005413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 573569005414 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573569005415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573569005416 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 573569005417 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 573569005418 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 573569005419 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 573569005420 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 573569005421 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 573569005422 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 573569005423 Protein of unknown function (DUF877); Region: DUF877; pfam05943 573569005424 Protein of unknown function (DUF770); Region: DUF770; pfam05591 573569005425 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 573569005426 aspartoacylase; Provisional; Region: PRK02259 573569005427 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 573569005428 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 573569005429 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 573569005430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573569005431 catalytic residue [active] 573569005432 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 573569005433 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 573569005434 substrate binding site [chemical binding]; other site 573569005435 active site 573569005436 catalytic residues [active] 573569005437 heterodimer interface [polypeptide binding]; other site 573569005438 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 573569005439 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 573569005440 active site 573569005441 catalytic triad [active] 573569005442 oxyanion hole [active] 573569005443 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 573569005444 Clp amino terminal domain; Region: Clp_N; pfam02861 573569005445 Clp amino terminal domain; Region: Clp_N; pfam02861 573569005446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573569005447 Walker A motif; other site 573569005448 ATP binding site [chemical binding]; other site 573569005449 Walker B motif; other site 573569005450 arginine finger; other site 573569005451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573569005452 Walker A motif; other site 573569005453 ATP binding site [chemical binding]; other site 573569005454 Walker B motif; other site 573569005455 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 573569005456 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 573569005457 active site 573569005458 major vault protein; Provisional; Region: PTZ00491 573569005459 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 573569005460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573569005461 ATP-grasp domain; Region: ATP-grasp; pfam02222 573569005462 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 573569005463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573569005464 Frag1/DRAM/Sfk1 family; Region: Frag1; pfam10277 573569005465 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573569005466 4Fe-4S binding domain; Region: Fer4; cl02805 573569005467 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 573569005468 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573569005469 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573569005470 putative acyl-acceptor binding pocket; other site 573569005471 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573569005472 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573569005473 putative acyl-acceptor binding pocket; other site 573569005474 hypothetical protein; Provisional; Region: PRK05421 573569005475 putative catalytic site [active] 573569005476 putative metal binding site [ion binding]; other site 573569005477 putative phosphate binding site [ion binding]; other site 573569005478 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854 573569005479 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 573569005480 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 573569005481 [2Fe-2S] cluster binding site [ion binding]; other site 573569005482 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 573569005483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569005484 metabolite-proton symporter; Region: 2A0106; TIGR00883 573569005485 putative substrate translocation pore; other site 573569005486 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 573569005487 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 573569005488 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 573569005489 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 573569005490 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573569005491 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573569005492 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 573569005493 catalytic triad [active] 573569005494 Acylphosphatase; Region: Acylphosphatase; pfam00708 573569005495 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 573569005496 HypF finger; Region: zf-HYPF; pfam07503 573569005497 HypF finger; Region: zf-HYPF; pfam07503 573569005498 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 573569005499 HupF/HypC family; Region: HupF_HypC; pfam01455 573569005500 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 573569005501 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 573569005502 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 573569005503 dimerization interface [polypeptide binding]; other site 573569005504 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 573569005505 ATP binding site [chemical binding]; other site 573569005506 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 573569005507 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 573569005508 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 573569005509 FAD binding pocket [chemical binding]; other site 573569005510 FAD binding motif [chemical binding]; other site 573569005511 phosphate binding motif [ion binding]; other site 573569005512 beta-alpha-beta structure motif; other site 573569005513 NAD binding pocket [chemical binding]; other site 573569005514 Iron coordination center [ion binding]; other site 573569005515 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 573569005516 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 573569005517 High-affinity nickel-transport protein; Region: NicO; cl00964 573569005518 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 573569005519 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 573569005520 nickel binding site [ion binding]; other site 573569005521 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 573569005522 dimer interface [polypeptide binding]; other site 573569005523 allosteric magnesium binding site [ion binding]; other site 573569005524 active site 573569005525 aspartate-rich active site metal binding site; other site 573569005526 Schiff base residues; other site 573569005527 potential frameshift: common BLAST hit: gi|209963923|ref|YP_002296838.1| cobalamin synthesis protein CobW 573569005528 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 573569005529 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 573569005530 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573569005531 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 573569005532 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573569005533 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 573569005534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573569005535 Walker A/P-loop; other site 573569005536 ATP binding site [chemical binding]; other site 573569005537 Q-loop/lid; other site 573569005538 ABC transporter signature motif; other site 573569005539 Walker B; other site 573569005540 D-loop; other site 573569005541 H-loop/switch region; other site 573569005542 ABC transporter; Region: ABC_tran_2; pfam12848 573569005543 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573569005544 metabolite-proton symporter; Region: 2A0106; TIGR00883 573569005545 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 573569005546 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 573569005547 LysE type translocator; Region: LysE; cl00565 573569005548 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 573569005549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573569005550 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573569005551 dimerization interface [polypeptide binding]; other site 573569005552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573569005553 putative substrate translocation pore; other site 573569005554 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573569005555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573569005556 Ureide permease; Region: Ureide_permease; pfam07168 573569005557 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 573569005558 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573569005559 substrate binding site [chemical binding]; other site 573569005560 dimer interface [polypeptide binding]; other site 573569005561 ATP binding site [chemical binding]; other site 573569005562 aminopeptidase N; Provisional; Region: pepN; PRK14015 573569005563 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 573569005564 active site 573569005565 Zn binding site [ion binding]; other site 573569005566 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 573569005567 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 573569005568 active site 573569005569 ribulose/triose binding site [chemical binding]; other site 573569005570 phosphate binding site [ion binding]; other site 573569005571 substrate (anthranilate) binding pocket [chemical binding]; other site 573569005572 product (indole) binding pocket [chemical binding]; other site 573569005573 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 573569005574 active site 573569005575 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 573569005576 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 573569005577 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 573569005578 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 573569005579 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 573569005580 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 573569005581 Glutamine amidotransferase class-I; Region: GATase; pfam00117 573569005582 glutamine binding [chemical binding]; other site 573569005583 catalytic triad [active] 573569005584 anthranilate synthase component I; Provisional; Region: PRK13564 573569005585 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 573569005586 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 573569005587 Trp repressor protein; Region: Trp_repressor; cl17266 573569005588 ribonuclease G; Provisional; Region: PRK11712 573569005589 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 573569005590 homodimer interface [polypeptide binding]; other site 573569005591 oligonucleotide binding site [chemical binding]; other site