-- dump date 20140619_094410 -- class Genbank::misc_feature -- table misc_feature_note -- id note 676032000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 676032000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 676032000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 676032000004 Walker A motif; other site 676032000005 ATP binding site [chemical binding]; other site 676032000006 Walker B motif; other site 676032000007 arginine finger; other site 676032000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 676032000009 DnaA box-binding interface [nucleotide binding]; other site 676032000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 676032000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 676032000012 putative DNA binding surface [nucleotide binding]; other site 676032000013 dimer interface [polypeptide binding]; other site 676032000014 beta-clamp/clamp loader binding surface; other site 676032000015 beta-clamp/translesion DNA polymerase binding surface; other site 676032000016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032000017 metabolite-proton symporter; Region: 2A0106; TIGR00883 676032000018 putative substrate translocation pore; other site 676032000019 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 676032000020 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 676032000021 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 676032000022 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 676032000023 Cl binding site [ion binding]; other site 676032000024 oligomer interface [polypeptide binding]; other site 676032000025 EamA-like transporter family; Region: EamA; pfam00892 676032000026 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 676032000027 EamA-like transporter family; Region: EamA; pfam00892 676032000028 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 676032000029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 676032000030 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 676032000031 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 676032000032 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 676032000033 integrase; Provisional; Region: PRK09692 676032000034 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 676032000035 active site 676032000036 Int/Topo IB signature motif; other site 676032000037 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 676032000038 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 676032000039 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 676032000040 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 676032000041 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 676032000042 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 676032000043 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 676032000044 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 676032000045 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 676032000046 ATP-grasp domain; Region: ATP-grasp_4; cl17255 676032000047 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 676032000048 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 676032000049 ATP-grasp domain; Region: ATP-grasp_4; cl17255 676032000050 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 676032000051 substrate binding site [chemical binding]; other site 676032000052 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 676032000053 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 676032000054 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 676032000055 catalytic site [active] 676032000056 subunit interface [polypeptide binding]; other site 676032000057 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 676032000058 catalytic core [active] 676032000059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032000060 S-adenosylmethionine binding site [chemical binding]; other site 676032000061 dihydroorotase; Reviewed; Region: PRK09236 676032000062 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 676032000063 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 676032000064 active site 676032000065 Putative amidotransferase; Region: DUF4066; pfam13278 676032000066 conserved cys residue [active] 676032000067 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 676032000068 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 676032000069 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 676032000070 SOUL heme-binding protein; Region: SOUL; pfam04832 676032000071 Chorismate mutase type II; Region: CM_2; smart00830 676032000072 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 676032000073 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 676032000074 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 676032000075 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 676032000076 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 676032000077 active site 676032000078 dimer interface [polypeptide binding]; other site 676032000079 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 676032000080 phosphate binding site [ion binding]; other site 676032000081 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 676032000082 prephenate dehydrogenase; Validated; Region: PRK08507 676032000083 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 676032000084 putative active site [active] 676032000085 dimerization interface [polypeptide binding]; other site 676032000086 putative tRNAtyr binding site [nucleotide binding]; other site 676032000087 putative transporter; Provisional; Region: PRK03699 676032000088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032000089 putative substrate translocation pore; other site 676032000090 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 676032000091 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 676032000092 substrate binding [chemical binding]; other site 676032000093 active site 676032000094 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 676032000095 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 676032000096 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 676032000097 substrate binding site [chemical binding]; other site 676032000098 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 676032000099 substrate binding site [chemical binding]; other site 676032000100 ligand binding site [chemical binding]; other site 676032000101 2-isopropylmalate synthase; Validated; Region: PRK00915 676032000102 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 676032000103 active site 676032000104 catalytic residues [active] 676032000105 metal binding site [ion binding]; metal-binding site 676032000106 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 676032000107 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 676032000108 homodimer interface [polypeptide binding]; other site 676032000109 substrate-cofactor binding pocket; other site 676032000110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032000111 catalytic residue [active] 676032000112 pyruvate phosphate dikinase; Provisional; Region: PRK09279 676032000113 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 676032000114 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 676032000115 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 676032000116 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 676032000117 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 676032000118 G1 box; other site 676032000119 GTP/Mg2+ binding site [chemical binding]; other site 676032000120 Switch I region; other site 676032000121 G2 box; other site 676032000122 G3 box; other site 676032000123 Switch II region; other site 676032000124 G4 box; other site 676032000125 G5 box; other site 676032000126 Nucleoside recognition; Region: Gate; pfam07670 676032000127 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 676032000128 Nucleoside recognition; Region: Gate; pfam07670 676032000129 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 676032000130 catalytic site [active] 676032000131 putative active site [active] 676032000132 putative substrate binding site [chemical binding]; other site 676032000133 dimer interface [polypeptide binding]; other site 676032000134 elongation factor P; Validated; Region: PRK00529 676032000135 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 676032000136 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 676032000137 RNA binding site [nucleotide binding]; other site 676032000138 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 676032000139 RNA binding site [nucleotide binding]; other site 676032000140 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 676032000141 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 676032000142 putative acyl-acceptor binding pocket; other site 676032000143 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 676032000144 putative acyl-acceptor binding pocket; other site 676032000145 membrane protein insertase; Provisional; Region: PRK01318 676032000146 YidC periplasmic domain; Region: YidC_periplas; pfam14849 676032000147 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 676032000148 hypothetical protein; Provisional; Region: PRK14375 676032000149 Ribonuclease P; Region: Ribonuclease_P; pfam00825 676032000150 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 676032000151 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 676032000152 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 676032000153 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 676032000154 NAD(P) binding pocket [chemical binding]; other site 676032000155 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 676032000156 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 676032000157 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 676032000158 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 676032000159 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 676032000160 putative SAM binding site [chemical binding]; other site 676032000161 putative homodimer interface [polypeptide binding]; other site 676032000162 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 676032000163 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 676032000164 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 676032000165 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 676032000166 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 676032000167 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 676032000168 PLD-like domain; Region: PLDc_2; pfam13091 676032000169 putative homodimer interface [polypeptide binding]; other site 676032000170 putative active site [active] 676032000171 catalytic site [active] 676032000172 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 676032000173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 676032000174 ATP binding site [chemical binding]; other site 676032000175 putative Mg++ binding site [ion binding]; other site 676032000176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 676032000177 nucleotide binding region [chemical binding]; other site 676032000178 ATP-binding site [chemical binding]; other site 676032000179 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 676032000180 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 676032000181 Ligand Binding Site [chemical binding]; other site 676032000182 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 676032000183 Ligand Binding Site [chemical binding]; other site 676032000184 metabolite-proton symporter; Region: 2A0106; TIGR00883 676032000185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032000186 putative substrate translocation pore; other site 676032000187 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 676032000188 LamB/YcsF family protein; Provisional; Region: PRK05406 676032000189 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 676032000190 Phosphoesterase family; Region: Phosphoesterase; pfam04185 676032000191 Phosphate transporter family; Region: PHO4; pfam01384 676032000192 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 676032000193 active site 676032000194 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 676032000195 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 676032000196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 676032000197 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 676032000198 putative FMN binding site [chemical binding]; other site 676032000199 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 676032000200 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 676032000201 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 676032000202 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 676032000203 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 676032000204 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 676032000205 catalytic residue [active] 676032000206 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 676032000207 Transcriptional regulator [Transcription]; Region: LysR; COG0583 676032000208 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 676032000209 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 676032000210 putative effector binding pocket; other site 676032000211 dimerization interface [polypeptide binding]; other site 676032000212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032000213 putative substrate translocation pore; other site 676032000214 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 676032000215 Glycosyl hydrolases related to GH101 family, GHL1-GHL3; Region: GHL1-3; pfam11308 676032000216 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 676032000217 dimer interface [polypeptide binding]; other site 676032000218 active site 676032000219 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 676032000220 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 676032000221 GTP-binding protein LepA; Provisional; Region: PRK05433 676032000222 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 676032000223 G1 box; other site 676032000224 putative GEF interaction site [polypeptide binding]; other site 676032000225 GTP/Mg2+ binding site [chemical binding]; other site 676032000226 Switch I region; other site 676032000227 G2 box; other site 676032000228 G3 box; other site 676032000229 Switch II region; other site 676032000230 G4 box; other site 676032000231 G5 box; other site 676032000232 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 676032000233 Elongation Factor G, domain II; Region: EFG_II; pfam14492 676032000234 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 676032000235 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 676032000236 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 676032000237 nudix motif; other site 676032000238 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 676032000239 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 676032000240 Ligand Binding Site [chemical binding]; other site 676032000241 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 676032000242 active site 676032000243 catalytic residues [active] 676032000244 metal binding site [ion binding]; metal-binding site 676032000245 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 676032000246 homopentamer interface [polypeptide binding]; other site 676032000247 active site 676032000248 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 676032000249 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 676032000250 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 676032000251 dimerization interface [polypeptide binding]; other site 676032000252 active site 676032000253 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 676032000254 Lumazine binding domain; Region: Lum_binding; pfam00677 676032000255 Lumazine binding domain; Region: Lum_binding; pfam00677 676032000256 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 676032000257 catalytic motif [active] 676032000258 Zn binding site [ion binding]; other site 676032000259 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 676032000260 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 676032000261 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 676032000262 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 676032000263 dimer interface [polypeptide binding]; other site 676032000264 PYR/PP interface [polypeptide binding]; other site 676032000265 TPP binding site [chemical binding]; other site 676032000266 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 676032000267 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 676032000268 TPP-binding site [chemical binding]; other site 676032000269 dimer interface [polypeptide binding]; other site 676032000270 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 676032000271 dimer interface [polypeptide binding]; other site 676032000272 [2Fe-2S] cluster binding site [ion binding]; other site 676032000273 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 676032000274 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 676032000275 tandem repeat interface [polypeptide binding]; other site 676032000276 oligomer interface [polypeptide binding]; other site 676032000277 active site residues [active] 676032000278 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 676032000279 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 676032000280 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 676032000281 SecA binding site; other site 676032000282 Preprotein binding site; other site 676032000283 recombinase A; Provisional; Region: recA; PRK09354 676032000284 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 676032000285 hexamer interface [polypeptide binding]; other site 676032000286 Walker A motif; other site 676032000287 ATP binding site [chemical binding]; other site 676032000288 Walker B motif; other site 676032000289 recombination regulator RecX; Reviewed; Region: recX; PRK00117 676032000290 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 676032000291 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 676032000292 dimer interface [polypeptide binding]; other site 676032000293 ssDNA binding site [nucleotide binding]; other site 676032000294 tetramer (dimer of dimers) interface [polypeptide binding]; other site 676032000295 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 676032000296 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 676032000297 phosphate acetyltransferase; Reviewed; Region: PRK05632 676032000298 DRTGG domain; Region: DRTGG; pfam07085 676032000299 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 676032000300 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 676032000301 tetramerization interface [polypeptide binding]; other site 676032000302 NAD(P) binding site [chemical binding]; other site 676032000303 catalytic residues [active] 676032000304 metabolite-proton symporter; Region: 2A0106; TIGR00883 676032000305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032000306 putative substrate translocation pore; other site 676032000307 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 676032000308 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 676032000309 dimer interface [polypeptide binding]; other site 676032000310 anticodon binding site; other site 676032000311 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 676032000312 homodimer interface [polypeptide binding]; other site 676032000313 motif 1; other site 676032000314 active site 676032000315 motif 2; other site 676032000316 GAD domain; Region: GAD; pfam02938 676032000317 motif 3; other site 676032000318 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 676032000319 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 676032000320 putative ADP-binding pocket [chemical binding]; other site 676032000321 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 676032000322 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 676032000323 RNB domain; Region: RNB; pfam00773 676032000324 Predicted esterase [General function prediction only]; Region: COG0400 676032000325 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 676032000326 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 676032000327 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 676032000328 domain interfaces; other site 676032000329 active site 676032000330 camphor resistance protein CrcB; Provisional; Region: PRK14226 676032000331 Zinc-finger domain; Region: zf-CHCC; cl01821 676032000332 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 676032000333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 676032000334 dimer interface [polypeptide binding]; other site 676032000335 conserved gate region; other site 676032000336 putative PBP binding loops; other site 676032000337 ABC-ATPase subunit interface; other site 676032000338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 676032000339 dimer interface [polypeptide binding]; other site 676032000340 conserved gate region; other site 676032000341 putative PBP binding loops; other site 676032000342 ABC-ATPase subunit interface; other site 676032000343 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 676032000344 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 676032000345 Walker A/P-loop; other site 676032000346 ATP binding site [chemical binding]; other site 676032000347 Q-loop/lid; other site 676032000348 ABC transporter signature motif; other site 676032000349 Walker B; other site 676032000350 D-loop; other site 676032000351 H-loop/switch region; other site 676032000352 C-terminal AAA-associated domain; Region: AAA_assoc_C; pfam09821 676032000353 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 676032000354 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 676032000355 TrkA-N domain; Region: TrkA_N; pfam02254 676032000356 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 676032000357 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 676032000358 trimer interface [polypeptide binding]; other site 676032000359 putative metal binding site [ion binding]; other site 676032000360 Outer membrane lipoprotein LolB; Region: LolB; cl19307 676032000361 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 676032000362 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 676032000363 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 676032000364 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 676032000365 putative active site [active] 676032000366 Zn binding site [ion binding]; other site 676032000367 YGGT family; Region: YGGT; pfam02325 676032000368 YGGT family; Region: YGGT; pfam02325 676032000369 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 676032000370 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 676032000371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 676032000372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 676032000373 Coenzyme A binding pocket [chemical binding]; other site 676032000374 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 676032000375 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 676032000376 ATP-grasp domain; Region: ATP-grasp_4; cl17255 676032000377 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 676032000378 Competence protein; Region: Competence; pfam03772 676032000379 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 676032000380 putative acyl-acceptor binding pocket; other site 676032000381 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 676032000382 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 676032000383 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 676032000384 RNA binding site [nucleotide binding]; other site 676032000385 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 676032000386 RNA binding site [nucleotide binding]; other site 676032000387 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 676032000388 RNA binding site [nucleotide binding]; other site 676032000389 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 676032000390 RNA binding site [nucleotide binding]; other site 676032000391 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 676032000392 RNA binding site [nucleotide binding]; other site 676032000393 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 676032000394 RNA binding site [nucleotide binding]; other site 676032000395 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 676032000396 nucleoside/Zn binding site; other site 676032000397 dimer interface [polypeptide binding]; other site 676032000398 catalytic motif [active] 676032000399 D-alanyl-alanine synthetase A; Provisional; Region: PRK14569 676032000400 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 676032000401 ATP-grasp domain; Region: ATP-grasp_4; cl17255 676032000402 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 676032000403 Cell division protein FtsQ; Region: FtsQ; pfam03799 676032000404 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 676032000405 Cell division protein FtsA; Region: FtsA; smart00842 676032000406 Cell division protein FtsA; Region: FtsA; pfam14450 676032000407 cell division protein FtsZ; Validated; Region: PRK09330 676032000408 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 676032000409 nucleotide binding site [chemical binding]; other site 676032000410 SulA interaction site; other site 676032000411 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 676032000412 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 676032000413 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 676032000414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 676032000415 Walker A motif; other site 676032000416 ATP binding site [chemical binding]; other site 676032000417 Walker B motif; other site 676032000418 DNA polymerase III subunit delta'; Validated; Region: PRK08485 676032000419 arginine finger; other site 676032000420 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 676032000421 This domain is found in peptide chain release factors; Region: PCRF; smart00937 676032000422 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 676032000423 RF-1 domain; Region: RF-1; pfam00472 676032000424 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 676032000425 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 676032000426 dimer interface [polypeptide binding]; other site 676032000427 putative anticodon binding site; other site 676032000428 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 676032000429 motif 1; other site 676032000430 active site 676032000431 motif 2; other site 676032000432 motif 3; other site 676032000433 hypothetical protein; Provisional; Region: PRK05208 676032000434 Glutaminase; Region: Glutaminase; cl00907 676032000435 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 676032000436 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 676032000437 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 676032000438 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 676032000439 glutamine synthetase; Region: PLN02284 676032000440 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 676032000441 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 676032000442 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 676032000443 Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840 676032000444 Lipocalin-like domain; Region: Lipocalin_2; cl19222 676032000445 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 676032000446 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 676032000447 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 676032000448 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 676032000449 purine monophosphate binding site [chemical binding]; other site 676032000450 dimer interface [polypeptide binding]; other site 676032000451 putative catalytic residues [active] 676032000452 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 676032000453 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 676032000454 GDP-binding site [chemical binding]; other site 676032000455 ACT binding site; other site 676032000456 IMP binding site; other site 676032000457 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 676032000458 active site 676032000459 Dienelactone hydrolase family; Region: DLH; pfam01738 676032000460 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 676032000461 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 676032000462 ABC-ATPase subunit interface; other site 676032000463 dimer interface [polypeptide binding]; other site 676032000464 putative PBP binding regions; other site 676032000465 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 676032000466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 676032000467 Walker A/P-loop; other site 676032000468 ATP binding site [chemical binding]; other site 676032000469 Q-loop/lid; other site 676032000470 ABC transporter signature motif; other site 676032000471 Walker B; other site 676032000472 D-loop; other site 676032000473 H-loop/switch region; other site 676032000474 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 676032000475 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 676032000476 intersubunit interface [polypeptide binding]; other site 676032000477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032000478 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032000479 putative substrate translocation pore; other site 676032000480 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 676032000481 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 676032000482 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 676032000483 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 676032000484 primosome assembly protein PriA; Validated; Region: PRK05580 676032000485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 676032000486 ATP binding site [chemical binding]; other site 676032000487 putative Mg++ binding site [ion binding]; other site 676032000488 helicase superfamily c-terminal domain; Region: HELICc; smart00490 676032000489 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 676032000490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032000491 putative substrate translocation pore; other site 676032000492 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 676032000493 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 676032000494 substrate binding pocket [chemical binding]; other site 676032000495 membrane-bound complex binding site; other site 676032000496 hinge residues; other site 676032000497 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 676032000498 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 676032000499 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 676032000500 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 676032000501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032000502 putative substrate translocation pore; other site 676032000503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032000504 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 676032000505 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 676032000506 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 676032000507 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 676032000508 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 676032000509 D-pathway; other site 676032000510 Putative ubiquinol binding site [chemical binding]; other site 676032000511 Low-spin heme (heme b) binding site [chemical binding]; other site 676032000512 Putative water exit pathway; other site 676032000513 Binuclear center (heme o3/CuB) [ion binding]; other site 676032000514 K-pathway; other site 676032000515 Putative proton exit pathway; other site 676032000516 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 676032000517 Subunit I/III interface [polypeptide binding]; other site 676032000518 Subunit III/IV interface [polypeptide binding]; other site 676032000519 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 676032000520 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 676032000521 putative active site [active] 676032000522 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 676032000523 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 676032000524 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 676032000525 trimer interface [polypeptide binding]; other site 676032000526 active site 676032000527 UDP-GlcNAc binding site [chemical binding]; other site 676032000528 lipid binding site [chemical binding]; lipid-binding site 676032000529 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 676032000530 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 676032000531 dimer interface [polypeptide binding]; other site 676032000532 pyridoxal binding site [chemical binding]; other site 676032000533 ATP binding site [chemical binding]; other site 676032000534 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 676032000535 MoxR-like ATPases [General function prediction only]; Region: COG0714 676032000536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 676032000537 Walker A motif; other site 676032000538 ATP binding site [chemical binding]; other site 676032000539 Walker B motif; other site 676032000540 arginine finger; other site 676032000541 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 676032000542 metal ion-dependent adhesion site (MIDAS); other site 676032000543 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 676032000544 hypothetical protein; Provisional; Region: PRK13685 676032000545 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 676032000546 metal ion-dependent adhesion site (MIDAS); other site 676032000547 von Willebrand factor type A domain; Region: VWA_2; pfam13519 676032000548 metal ion-dependent adhesion site (MIDAS); other site 676032000549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 676032000550 Tetratricopeptide repeat; Region: TPR_16; pfam13432 676032000551 TPR motif; other site 676032000552 binding surface 676032000553 Oxygen tolerance; Region: BatD; pfam13584 676032000554 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 676032000555 putative substrate binding pocket [chemical binding]; other site 676032000556 AC domain interface; other site 676032000557 catalytic triad [active] 676032000558 AB domain interface; other site 676032000559 interchain disulfide; other site 676032000560 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 676032000561 Domain of unknown function (DUF897); Region: DUF897; cl01312 676032000562 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 676032000563 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 676032000564 active site 676032000565 HIGH motif; other site 676032000566 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 676032000567 KMSKS motif; other site 676032000568 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 676032000569 tRNA binding surface [nucleotide binding]; other site 676032000570 anticodon binding site; other site 676032000571 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 676032000572 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 676032000573 homotrimer interaction site [polypeptide binding]; other site 676032000574 putative active site [active] 676032000575 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 676032000576 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 676032000577 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 676032000578 active site 676032000579 FMN binding site [chemical binding]; other site 676032000580 substrate binding site [chemical binding]; other site 676032000581 putative catalytic residues [active] 676032000582 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 676032000583 dimer interface [polypeptide binding]; other site 676032000584 FMN binding site [chemical binding]; other site 676032000585 Herpesvirus UL36 tegument protein; Region: Herpes_UL36; pfam03586 676032000586 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 676032000587 nudix motif; other site 676032000588 fumarate hydratase; Reviewed; Region: fumC; PRK00485 676032000589 Class II fumarases; Region: Fumarase_classII; cd01362 676032000590 active site 676032000591 tetramer interface [polypeptide binding]; other site 676032000592 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 676032000593 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 676032000594 active site 676032000595 HIGH motif; other site 676032000596 KMSKS motif; other site 676032000597 Amidinotransferase; Region: Amidinotransf; pfam02274 676032000598 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 676032000599 folate binding site [chemical binding]; other site 676032000600 NADP+ binding site [chemical binding]; other site 676032000601 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 676032000602 rRNA interaction site [nucleotide binding]; other site 676032000603 S8 interaction site; other site 676032000604 putative laminin-1 binding site; other site 676032000605 elongation factor Ts; Provisional; Region: tsf; PRK09377 676032000606 UBA/TS-N domain; Region: UBA; pfam00627 676032000607 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 676032000608 putative nucleotide binding site [chemical binding]; other site 676032000609 uridine monophosphate binding site [chemical binding]; other site 676032000610 homohexameric interface [polypeptide binding]; other site 676032000611 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 676032000612 hinge region; other site 676032000613 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 676032000614 active site 676032000615 dimer interface [polypeptide binding]; other site 676032000616 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 676032000617 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 676032000618 trimer interface [polypeptide binding]; other site 676032000619 active site 676032000620 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 676032000621 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 676032000622 S17 interaction site [polypeptide binding]; other site 676032000623 S8 interaction site; other site 676032000624 16S rRNA interaction site [nucleotide binding]; other site 676032000625 streptomycin interaction site [chemical binding]; other site 676032000626 23S rRNA interaction site [nucleotide binding]; other site 676032000627 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 676032000628 30S ribosomal protein S7; Validated; Region: PRK05302 676032000629 elongation factor G; Reviewed; Region: PRK00007 676032000630 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 676032000631 G1 box; other site 676032000632 putative GEF interaction site [polypeptide binding]; other site 676032000633 GTP/Mg2+ binding site [chemical binding]; other site 676032000634 Switch I region; other site 676032000635 G2 box; other site 676032000636 G3 box; other site 676032000637 Switch II region; other site 676032000638 G4 box; other site 676032000639 G5 box; other site 676032000640 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 676032000641 Elongation Factor G, domain II; Region: EFG_II; pfam14492 676032000642 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 676032000643 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 676032000644 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 676032000645 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 676032000646 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 676032000647 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 676032000648 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 676032000649 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 676032000650 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 676032000651 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 676032000652 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 676032000653 putative translocon binding site; other site 676032000654 protein-rRNA interface [nucleotide binding]; other site 676032000655 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 676032000656 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 676032000657 G-X-X-G motif; other site 676032000658 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 676032000659 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 676032000660 23S rRNA interface [nucleotide binding]; other site 676032000661 5S rRNA interface [nucleotide binding]; other site 676032000662 putative antibiotic binding site [chemical binding]; other site 676032000663 L25 interface [polypeptide binding]; other site 676032000664 L27 interface [polypeptide binding]; other site 676032000665 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 676032000666 23S rRNA interface [nucleotide binding]; other site 676032000667 putative translocon interaction site; other site 676032000668 signal recognition particle (SRP54) interaction site; other site 676032000669 L23 interface [polypeptide binding]; other site 676032000670 trigger factor interaction site; other site 676032000671 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 676032000672 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 676032000673 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 676032000674 RNA binding site [nucleotide binding]; other site 676032000675 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 676032000676 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 676032000677 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 676032000678 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 676032000679 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 676032000680 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 676032000681 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 676032000682 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 676032000683 23S rRNA interface [nucleotide binding]; other site 676032000684 L21e interface [polypeptide binding]; other site 676032000685 5S rRNA interface [nucleotide binding]; other site 676032000686 L27 interface [polypeptide binding]; other site 676032000687 L5 interface [polypeptide binding]; other site 676032000688 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 676032000689 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 676032000690 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 676032000691 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 676032000692 23S rRNA binding site [nucleotide binding]; other site 676032000693 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 676032000694 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 676032000695 SecY translocase; Region: SecY; pfam00344 676032000696 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 676032000697 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 676032000698 30S ribosomal protein S11; Validated; Region: PRK05309 676032000699 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 676032000700 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 676032000701 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 676032000702 RNA binding surface [nucleotide binding]; other site 676032000703 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 676032000704 alphaNTD homodimer interface [polypeptide binding]; other site 676032000705 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 676032000706 alphaNTD - beta interaction site [polypeptide binding]; other site 676032000707 alphaNTD - beta' interaction site [polypeptide binding]; other site 676032000708 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 676032000709 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 676032000710 heat shock protein 90; Provisional; Region: PRK05218 676032000711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 676032000712 ATP binding site [chemical binding]; other site 676032000713 Mg2+ binding site [ion binding]; other site 676032000714 G-X-G motif; other site 676032000715 Hsp90 protein; Region: HSP90; pfam00183 676032000716 hypothetical protein; Provisional; Region: PRK11588 676032000717 CTP synthetase; Validated; Region: pyrG; PRK05380 676032000718 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 676032000719 Catalytic site [active] 676032000720 active site 676032000721 UTP binding site [chemical binding]; other site 676032000722 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 676032000723 active site 676032000724 putative oxyanion hole; other site 676032000725 catalytic triad [active] 676032000726 Nucleoside diphosphate kinase; Region: NDK; pfam00334 676032000727 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 676032000728 active site 676032000729 multimer interface [polypeptide binding]; other site 676032000730 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 676032000731 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 676032000732 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 676032000733 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 676032000734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 676032000735 Walker A motif; other site 676032000736 ATP binding site [chemical binding]; other site 676032000737 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 676032000738 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 676032000739 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 676032000740 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 676032000741 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 676032000742 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 676032000743 ferredoxin-NADP reductase; Provisional; Region: PRK10926 676032000744 FAD binding pocket [chemical binding]; other site 676032000745 FAD binding motif [chemical binding]; other site 676032000746 phosphate binding motif [ion binding]; other site 676032000747 beta-alpha-beta structure motif; other site 676032000748 NAD binding pocket [chemical binding]; other site 676032000749 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 676032000750 SnoaL-like domain; Region: SnoaL_2; pfam12680 676032000751 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 676032000752 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u4; cd03407 676032000753 ProQ/FINO family; Region: ProQ; smart00945 676032000754 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 676032000755 Cation transport protein; Region: TrkH; cl17365 676032000756 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 676032000757 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 676032000758 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 676032000759 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 676032000760 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 676032000761 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 676032000762 active site 676032000763 lysine transporter; Provisional; Region: PRK10836 676032000764 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 676032000765 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 676032000766 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 676032000767 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 676032000768 putative active site [active] 676032000769 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 676032000770 Na binding site [ion binding]; other site 676032000771 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 676032000772 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 676032000773 DXD motif; other site 676032000774 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 676032000775 Domain of unknown function DUF21; Region: DUF21; pfam01595 676032000776 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 676032000777 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 676032000778 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 676032000779 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 676032000780 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 676032000781 aromatic chitin/cellulose binding site residues [chemical binding]; other site 676032000782 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 676032000783 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 676032000784 active site 676032000785 HIGH motif; other site 676032000786 KMSKS motif; other site 676032000787 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 676032000788 tRNA binding surface [nucleotide binding]; other site 676032000789 anticodon binding site; other site 676032000790 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 676032000791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032000792 S-adenosylmethionine binding site [chemical binding]; other site 676032000793 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 676032000794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032000795 putative substrate translocation pore; other site 676032000796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 676032000797 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 676032000798 Coenzyme A binding pocket [chemical binding]; other site 676032000799 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 676032000800 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 676032000801 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 676032000802 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 676032000803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032000804 S-adenosylmethionine binding site [chemical binding]; other site 676032000805 VacJ like lipoprotein; Region: VacJ; cl01073 676032000806 BolA-like protein; Region: BolA; cl00386 676032000807 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 676032000808 anti sigma factor interaction site; other site 676032000809 regulatory phosphorylation site [posttranslational modification]; other site 676032000810 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 676032000811 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 676032000812 mce related protein; Region: MCE; pfam02470 676032000813 Permease; Region: Permease; pfam02405 676032000814 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 676032000815 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 676032000816 Walker A/P-loop; other site 676032000817 ATP binding site [chemical binding]; other site 676032000818 Q-loop/lid; other site 676032000819 ABC transporter signature motif; other site 676032000820 Walker B; other site 676032000821 D-loop; other site 676032000822 H-loop/switch region; other site 676032000823 cell division topological specificity factor MinE; Provisional; Region: PRK13990 676032000824 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 676032000825 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 676032000826 P-loop; other site 676032000827 ADP binding residues [chemical binding]; other site 676032000828 Switch I; other site 676032000829 Switch II; other site 676032000830 septum formation inhibitor; Reviewed; Region: minC; PRK04804 676032000831 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 676032000832 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 676032000833 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 676032000834 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 676032000835 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 676032000836 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 676032000837 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 676032000838 ssDNA binding site; other site 676032000839 generic binding surface II; other site 676032000840 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 676032000841 ATP binding site [chemical binding]; other site 676032000842 putative Mg++ binding site [ion binding]; other site 676032000843 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 676032000844 nucleotide binding region [chemical binding]; other site 676032000845 ATP-binding site [chemical binding]; other site 676032000846 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 676032000847 Fumarase C-terminus; Region: Fumerase_C; pfam05683 676032000848 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 676032000849 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 676032000850 nudix motif; other site 676032000851 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 676032000852 catalytic residue [active] 676032000853 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 676032000854 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 676032000855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032000856 homodimer interface [polypeptide binding]; other site 676032000857 catalytic residue [active] 676032000858 TrkA-C domain; Region: TrkA_C; pfam02080 676032000859 TrkA-C domain; Region: TrkA_C; pfam02080 676032000860 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 676032000861 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 676032000862 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 676032000863 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 676032000864 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 676032000865 ligand binding site [chemical binding]; other site 676032000866 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl19519 676032000867 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 676032000868 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 676032000869 Fe-S cluster binding site [ion binding]; other site 676032000870 substrate binding site [chemical binding]; other site 676032000871 catalytic site [active] 676032000872 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 676032000873 homotrimer interaction site [polypeptide binding]; other site 676032000874 active site 676032000875 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 676032000876 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 676032000877 TolQ protein; Region: tolQ; TIGR02796 676032000878 TolR protein; Region: tolR; TIGR02801 676032000879 TolA protein; Region: tolA_full; TIGR02794 676032000880 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 676032000881 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 676032000882 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 676032000883 TolB amino-terminal domain; Region: TolB_N; pfam04052 676032000884 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 676032000885 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 676032000886 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 676032000887 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 676032000888 ligand binding site [chemical binding]; other site 676032000889 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 676032000890 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 676032000891 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 676032000892 FeS/SAM binding site; other site 676032000893 TRAM domain; Region: TRAM; cl01282 676032000894 short chain dehydrogenase; Provisional; Region: PRK07060 676032000895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 676032000896 NAD(P) binding site [chemical binding]; other site 676032000897 active site 676032000898 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 676032000899 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 676032000900 DNA photolyase; Region: DNA_photolyase; pfam00875 676032000901 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 676032000902 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 676032000903 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 676032000904 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 676032000905 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 676032000906 Sodium Bile acid symporter family; Region: SBF; cl19217 676032000907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 676032000908 YheO-like PAS domain; Region: PAS_6; pfam08348 676032000909 HTH domain; Region: HTH_22; pfam13309 676032000910 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 676032000911 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 676032000912 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 676032000913 transmembrane helices; other site 676032000914 Protein of unknown function (DUF423); Region: DUF423; pfam04241 676032000915 Protein of unknown function, DUF393; Region: DUF393; pfam04134 676032000916 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 676032000917 putative active site [active] 676032000918 Chorismate lyase; Region: Chor_lyase; cl01230 676032000919 ribonuclease PH; Reviewed; Region: rph; PRK00173 676032000920 Ribonuclease PH; Region: RNase_PH_bact; cd11362 676032000921 hexamer interface [polypeptide binding]; other site 676032000922 active site 676032000923 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 676032000924 heat shock protein HtpX; Provisional; Region: PRK02870 676032000925 LemA family; Region: LemA; cl00742 676032000926 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 676032000927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 676032000928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 676032000929 dimerization interface [polypeptide binding]; other site 676032000930 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 676032000931 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 676032000932 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 676032000933 Soluble P-type ATPase [General function prediction only]; Region: COG4087 676032000934 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 676032000935 putative Zn2+ binding site [ion binding]; other site 676032000936 putative DNA binding site [nucleotide binding]; other site 676032000937 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 676032000938 putative active site [active] 676032000939 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 676032000940 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 676032000941 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 676032000942 DNA repair protein RadA; Provisional; Region: PRK11823 676032000943 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 676032000944 Walker A motif/ATP binding site; other site 676032000945 ATP binding site [chemical binding]; other site 676032000946 Walker B motif; other site 676032000947 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 676032000948 PilZ domain; Region: PilZ; pfam07238 676032000949 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 676032000950 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 676032000951 Tetramer interface [polypeptide binding]; other site 676032000952 active site 676032000953 FMN-binding site [chemical binding]; other site 676032000954 PQ loop repeat; Region: PQ-loop; pfam04193 676032000955 methionine sulfoxide reductase B; Provisional; Region: PRK00222 676032000956 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 676032000957 E-class dimer interface [polypeptide binding]; other site 676032000958 P-class dimer interface [polypeptide binding]; other site 676032000959 active site 676032000960 Cu2+ binding site [ion binding]; other site 676032000961 Zn2+ binding site [ion binding]; other site 676032000962 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 676032000963 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 676032000964 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 676032000965 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 676032000966 Cupin domain; Region: Cupin_2; cl17218 676032000967 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 676032000968 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 676032000969 substrate binding site [chemical binding]; other site 676032000970 catalytic Zn binding site [ion binding]; other site 676032000971 NAD binding site [chemical binding]; other site 676032000972 structural Zn binding site [ion binding]; other site 676032000973 dimer interface [polypeptide binding]; other site 676032000974 aspartate aminotransferase; Provisional; Region: PRK07568 676032000975 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 676032000976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032000977 homodimer interface [polypeptide binding]; other site 676032000978 catalytic residue [active] 676032000979 Cation efflux family; Region: Cation_efflux; pfam01545 676032000980 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 676032000981 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 676032000982 Walker A/P-loop; other site 676032000983 ATP binding site [chemical binding]; other site 676032000984 Q-loop/lid; other site 676032000985 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 676032000986 ABC transporter signature motif; other site 676032000987 Walker B; other site 676032000988 D-loop; other site 676032000989 H-loop/switch region; other site 676032000990 Pilin (bacterial filament); Region: Pilin; pfam00114 676032000991 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 676032000992 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 676032000993 Pilin (bacterial filament); Region: Pilin; pfam00114 676032000994 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 676032000995 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 676032000996 active site 676032000997 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 676032000998 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 676032000999 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 676032001000 homodimer interface [polypeptide binding]; other site 676032001001 NADP binding site [chemical binding]; other site 676032001002 substrate binding site [chemical binding]; other site 676032001003 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 676032001004 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 676032001005 dimerization interface [polypeptide binding]; other site 676032001006 putative ATP binding site [chemical binding]; other site 676032001007 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 676032001008 active site 676032001009 ATP binding site [chemical binding]; other site 676032001010 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 676032001011 substrate binding site [chemical binding]; other site 676032001012 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 676032001013 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 676032001014 ATP-grasp domain; Region: ATP-grasp_4; cl17255 676032001015 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 676032001016 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 676032001017 active site 676032001018 substrate binding site [chemical binding]; other site 676032001019 cosubstrate binding site; other site 676032001020 catalytic site [active] 676032001021 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 676032001022 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 676032001023 ATP-grasp domain; Region: ATP-grasp_4; cl17255 676032001024 hypothetical protein; Provisional; Region: PRK14682 676032001025 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 676032001026 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 676032001027 active site 676032001028 Zn binding site [ion binding]; other site 676032001029 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 676032001030 hypothetical protein; Provisional; Region: PRK11281 676032001031 Protein of unknown function (DUF342); Region: DUF342; cl19219 676032001032 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 676032001033 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 676032001034 O-Antigen ligase; Region: Wzy_C; pfam04932 676032001035 DNA topoisomerase I; Validated; Region: PRK06599 676032001036 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 676032001037 active site 676032001038 interdomain interaction site; other site 676032001039 putative metal-binding site [ion binding]; other site 676032001040 nucleotide binding site [chemical binding]; other site 676032001041 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 676032001042 domain I; other site 676032001043 DNA binding groove [nucleotide binding] 676032001044 phosphate binding site [ion binding]; other site 676032001045 domain II; other site 676032001046 domain III; other site 676032001047 nucleotide binding site [chemical binding]; other site 676032001048 catalytic site [active] 676032001049 domain IV; other site 676032001050 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 676032001051 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 676032001052 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 676032001053 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 676032001054 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 676032001055 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 676032001056 P-loop; other site 676032001057 Magnesium ion binding site [ion binding]; other site 676032001058 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 676032001059 ParB-like nuclease domain; Region: ParB; smart00470 676032001060 KorB domain; Region: KorB; pfam08535 676032001061 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 676032001062 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 676032001063 catalytic triad [active] 676032001064 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 676032001065 active site 676032001066 catalytic triad [active] 676032001067 oxyanion hole [active] 676032001068 HD domain; Region: HD_3; pfam13023 676032001069 FtsJ-like methyltransferase; Region: FtsJ; cl17430 676032001070 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 676032001071 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 676032001072 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 676032001073 active site 676032001074 HIGH motif; other site 676032001075 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 676032001076 KMSKS motif; other site 676032001077 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 676032001078 tRNA binding surface [nucleotide binding]; other site 676032001079 anticodon binding site; other site 676032001080 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 676032001081 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 676032001082 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 676032001083 active site 676032001084 Riboflavin kinase; Region: Flavokinase; pfam01687 676032001085 malate dehydrogenase; Provisional; Region: PRK13529 676032001086 Malic enzyme, N-terminal domain; Region: malic; pfam00390 676032001087 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 676032001088 NAD(P) binding pocket [chemical binding]; other site 676032001089 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 676032001090 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 676032001091 GTP-binding protein Der; Reviewed; Region: PRK00093 676032001092 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 676032001093 G1 box; other site 676032001094 GTP/Mg2+ binding site [chemical binding]; other site 676032001095 Switch I region; other site 676032001096 G2 box; other site 676032001097 Switch II region; other site 676032001098 G3 box; other site 676032001099 G4 box; other site 676032001100 G5 box; other site 676032001101 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 676032001102 G1 box; other site 676032001103 GTP/Mg2+ binding site [chemical binding]; other site 676032001104 Switch I region; other site 676032001105 G2 box; other site 676032001106 G3 box; other site 676032001107 Switch II region; other site 676032001108 G4 box; other site 676032001109 G5 box; other site 676032001110 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 676032001111 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 676032001112 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 676032001113 putative active site [active] 676032001114 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 676032001115 FAD binding domain; Region: FAD_binding_4; pfam01565 676032001116 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 676032001117 Archaeal S-adenosylmethionine synthetase [Amino acid transport and metabolism]; Region: MetK; COG1812 676032001118 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 676032001119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032001120 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 676032001121 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 676032001122 active site 676032001123 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 676032001124 nucleotide binding site/active site [active] 676032001125 HIT family signature motif; other site 676032001126 catalytic residue [active] 676032001127 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 676032001128 ABC1 family; Region: ABC1; cl17513 676032001129 SCP-2 sterol transfer family; Region: SCP2; cl01225 676032001130 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 676032001131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032001132 S-adenosylmethionine binding site [chemical binding]; other site 676032001133 Glucokinase; Region: Glucokinase; pfam02685 676032001134 intracellular septation protein A; Reviewed; Region: PRK00259 676032001135 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 676032001136 Uncharacterized conserved protein [Function unknown]; Region: COG1739 676032001137 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 676032001138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001139 D-galactonate transporter; Region: 2A0114; TIGR00893 676032001140 putative substrate translocation pore; other site 676032001141 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 676032001142 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 676032001143 active site 676032001144 KMSKS motif; other site 676032001145 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 676032001146 tRNA binding surface [nucleotide binding]; other site 676032001147 anticodon binding site; other site 676032001148 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 676032001149 dimer interface [polypeptide binding]; other site 676032001150 putative tRNA-binding site [nucleotide binding]; other site 676032001151 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 676032001152 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 676032001153 Peptidase family M50; Region: Peptidase_M50; pfam02163 676032001154 active site 676032001155 putative substrate binding region [chemical binding]; other site 676032001156 META domain; Region: META; cl01245 676032001157 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 676032001158 DNA binding residues [nucleotide binding] 676032001159 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 676032001160 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 676032001161 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 676032001162 active site 676032001163 (T/H)XGH motif; other site 676032001164 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 676032001165 nudix motif; other site 676032001166 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 676032001167 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 676032001168 Substrate binding site; other site 676032001169 Mg++ binding site; other site 676032001170 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 676032001171 active site 676032001172 substrate binding site [chemical binding]; other site 676032001173 CoA binding site [chemical binding]; other site 676032001174 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 676032001175 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 676032001176 glutaminase active site [active] 676032001177 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 676032001178 dimer interface [polypeptide binding]; other site 676032001179 active site 676032001180 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 676032001181 dimer interface [polypeptide binding]; other site 676032001182 active site 676032001183 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 676032001184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 676032001185 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 676032001186 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 676032001187 DNA-binding site [nucleotide binding]; DNA binding site 676032001188 RNA-binding motif; other site 676032001189 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 676032001190 metal binding site [ion binding]; metal-binding site 676032001191 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 676032001192 active site 676032001193 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 676032001194 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 676032001195 CAP-like domain; other site 676032001196 active site 676032001197 primary dimer interface [polypeptide binding]; other site 676032001198 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 676032001199 BNR repeat-like domain; Region: BNR_2; pfam13088 676032001200 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 676032001201 Asp-box motif; other site 676032001202 catalytic site [active] 676032001203 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 676032001204 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 676032001205 N-acetyl-D-glucosamine binding site [chemical binding]; other site 676032001206 catalytic residue [active] 676032001207 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 676032001208 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 676032001209 Predicted membrane protein [Function unknown]; Region: COG4325 676032001210 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 676032001211 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 676032001212 active site 676032001213 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 676032001214 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 676032001215 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 676032001216 generic binding surface II; other site 676032001217 generic binding surface I; other site 676032001218 Restriction endonuclease; Region: Mrr_cat; cl19295 676032001219 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 676032001220 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 676032001221 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 676032001222 active site 676032001223 catalytic residues [active] 676032001224 metal binding site [ion binding]; metal-binding site 676032001225 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 676032001226 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 676032001227 FtsX-like permease family; Region: FtsX; pfam02687 676032001228 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 676032001229 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 676032001230 Walker A/P-loop; other site 676032001231 ATP binding site [chemical binding]; other site 676032001232 Q-loop/lid; other site 676032001233 ABC transporter signature motif; other site 676032001234 Walker B; other site 676032001235 D-loop; other site 676032001236 H-loop/switch region; other site 676032001237 lysine decarboxylase LdcC; Provisional; Region: PRK15399 676032001238 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 676032001239 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 676032001240 homodimer interface [polypeptide binding]; other site 676032001241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032001242 catalytic residue [active] 676032001243 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 676032001244 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 676032001245 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 676032001246 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 676032001247 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 676032001248 lipoyl attachment site [posttranslational modification]; other site 676032001249 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 676032001250 tetramer interface [polypeptide binding]; other site 676032001251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032001252 catalytic residue [active] 676032001253 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 676032001254 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 676032001255 catalytic residue [active] 676032001256 Predicted helicase [General function prediction only]; Region: COG4889 676032001257 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 676032001258 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 676032001259 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 676032001260 NAD(P) binding pocket [chemical binding]; other site 676032001261 pullulanase, type I; Region: pulA_typeI; TIGR02104 676032001262 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 676032001263 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 676032001264 Ca binding site [ion binding]; other site 676032001265 active site 676032001266 catalytic site [active] 676032001267 glycogen branching enzyme; Provisional; Region: PRK12313 676032001268 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 676032001269 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 676032001270 active site 676032001271 catalytic site [active] 676032001272 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 676032001273 phosphoglucomutase; Region: PLN02307 676032001274 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 676032001275 substrate binding site [chemical binding]; other site 676032001276 dimer interface [polypeptide binding]; other site 676032001277 active site 676032001278 metal binding site [ion binding]; metal-binding site 676032001279 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 676032001280 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 676032001281 ligand binding site; other site 676032001282 oligomer interface; other site 676032001283 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 676032001284 dimer interface [polypeptide binding]; other site 676032001285 N-terminal domain interface [polypeptide binding]; other site 676032001286 sulfate 1 binding site; other site 676032001287 glycogen synthase; Provisional; Region: glgA; PRK00654 676032001288 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 676032001289 ADP-binding pocket [chemical binding]; other site 676032001290 homodimer interface [polypeptide binding]; other site 676032001291 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 676032001292 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 676032001293 4-alpha-glucanotransferase; Provisional; Region: PRK14508 676032001294 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 676032001295 dimer interface [polypeptide binding]; other site 676032001296 motif 1; other site 676032001297 active site 676032001298 motif 2; other site 676032001299 motif 3; other site 676032001300 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 676032001301 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 676032001302 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 676032001303 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 676032001304 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 676032001305 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 676032001306 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 676032001307 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 676032001308 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 676032001309 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 676032001310 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 676032001311 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 676032001312 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 676032001313 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 676032001314 nucleotide binding site [chemical binding]; other site 676032001315 substrate binding site [chemical binding]; other site 676032001316 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 676032001317 dimer interface [polypeptide binding]; other site 676032001318 putative threonine allosteric regulatory site; other site 676032001319 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 676032001320 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 676032001321 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 676032001322 homoserine kinase; Provisional; Region: PRK01212 676032001323 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 676032001324 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 676032001325 threonine synthase; Validated; Region: PRK09225 676032001326 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 676032001327 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 676032001328 catalytic residue [active] 676032001329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001330 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032001331 putative substrate translocation pore; other site 676032001332 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 676032001333 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 676032001334 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 676032001335 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 676032001336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032001337 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 676032001338 dimer interface [polypeptide binding]; other site 676032001339 active site 676032001340 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 676032001341 catalytic residues [active] 676032001342 substrate binding site [chemical binding]; other site 676032001343 Amidinotransferase; Region: Amidinotransf; cl19186 676032001344 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 676032001345 putative active site; other site 676032001346 catalytic triad [active] 676032001347 putative dimer interface [polypeptide binding]; other site 676032001348 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 676032001349 putative active site [active] 676032001350 putative metal binding site [ion binding]; other site 676032001351 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 676032001352 active site 676032001353 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 676032001354 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 676032001355 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 676032001356 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 676032001357 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 676032001358 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 676032001359 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 676032001360 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 676032001361 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 676032001362 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 676032001363 active site 676032001364 HIGH motif; other site 676032001365 KMSK motif region; other site 676032001366 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 676032001367 tRNA binding surface [nucleotide binding]; other site 676032001368 anticodon binding site; other site 676032001369 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 676032001370 OstA-like protein; Region: OstA; cl00844 676032001371 Organic solvent tolerance protein; Region: OstA_C; pfam04453 676032001372 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 676032001373 SurA N-terminal domain; Region: SurA_N; pfam09312 676032001374 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 676032001375 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 676032001376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032001377 S-adenosylmethionine binding site [chemical binding]; other site 676032001378 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 676032001379 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 676032001380 active site 676032001381 metal binding site [ion binding]; metal-binding site 676032001382 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 676032001383 trimer interface [polypeptide binding]; other site 676032001384 active site 676032001385 dimer interface [polypeptide binding]; other site 676032001386 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 676032001387 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 676032001388 carboxyltransferase (CT) interaction site; other site 676032001389 biotinylation site [posttranslational modification]; other site 676032001390 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 676032001391 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 676032001392 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 676032001393 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 676032001394 Helix-turn-helix domain; Region: HTH_25; pfam13413 676032001395 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 676032001396 Mechanosensitive ion channel; Region: MS_channel; pfam00924 676032001397 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 676032001398 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 676032001399 motif 1; other site 676032001400 dimer interface [polypeptide binding]; other site 676032001401 active site 676032001402 motif 2; other site 676032001403 motif 3; other site 676032001404 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 676032001405 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 676032001406 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 676032001407 DHH family; Region: DHH; pfam01368 676032001408 DHHA1 domain; Region: DHHA1; pfam02272 676032001409 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 676032001410 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 676032001411 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 676032001412 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 676032001413 GTPase RsgA; Reviewed; Region: PRK00098 676032001414 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 676032001415 RNA binding site [nucleotide binding]; other site 676032001416 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 676032001417 GTPase/Zn-binding domain interface [polypeptide binding]; other site 676032001418 GTP/Mg2+ binding site [chemical binding]; other site 676032001419 G4 box; other site 676032001420 G5 box; other site 676032001421 G1 box; other site 676032001422 Switch I region; other site 676032001423 G2 box; other site 676032001424 G3 box; other site 676032001425 Switch II region; other site 676032001426 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 676032001427 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 676032001428 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 676032001429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 676032001430 ATP binding site [chemical binding]; other site 676032001431 Mg2+ binding site [ion binding]; other site 676032001432 G-X-G motif; other site 676032001433 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 676032001434 ATP binding site [chemical binding]; other site 676032001435 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 676032001436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001437 putative substrate translocation pore; other site 676032001438 H+ Antiporter protein; Region: 2A0121; TIGR00900 676032001439 D-galactonate transporter; Region: 2A0114; TIGR00893 676032001440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001441 putative substrate translocation pore; other site 676032001442 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 676032001443 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 676032001444 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 676032001445 phosphoglycolate phosphatase; Provisional; Region: PRK13222 676032001446 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 676032001447 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 676032001448 motif II; other site 676032001449 Transcriptional regulator [Transcription]; Region: LysR; COG0583 676032001450 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 676032001451 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 676032001452 putative effector binding pocket; other site 676032001453 dimerization interface [polypeptide binding]; other site 676032001454 MFS transport protein AraJ; Provisional; Region: PRK10091 676032001455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001456 putative substrate translocation pore; other site 676032001457 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 676032001458 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 676032001459 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 676032001460 active site 676032001461 dimer interface [polypeptide binding]; other site 676032001462 catalytic nucleophile [active] 676032001463 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 676032001464 POT family; Region: PTR2; cl17359 676032001465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001466 putative substrate translocation pore; other site 676032001467 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 676032001468 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 676032001469 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 676032001470 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 676032001471 NADP binding site [chemical binding]; other site 676032001472 homodimer interface [polypeptide binding]; other site 676032001473 active site 676032001474 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 676032001475 CoA binding domain; Region: CoA_binding; smart00881 676032001476 CoA-ligase; Region: Ligase_CoA; pfam00549 676032001477 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 676032001478 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 676032001479 CoA-ligase; Region: Ligase_CoA; pfam00549 676032001480 TIGR03546 family protein; Region: TIGR03546 676032001481 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 676032001482 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 676032001483 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 676032001484 FMN binding site [chemical binding]; other site 676032001485 active site 676032001486 catalytic residues [active] 676032001487 substrate binding site [chemical binding]; other site 676032001488 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 676032001489 putative active site pocket [active] 676032001490 dimerization interface [polypeptide binding]; other site 676032001491 putative catalytic residue [active] 676032001492 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 676032001493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 676032001494 ATP binding site [chemical binding]; other site 676032001495 Mg2+ binding site [ion binding]; other site 676032001496 G-X-G motif; other site 676032001497 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 676032001498 anchoring element; other site 676032001499 dimer interface [polypeptide binding]; other site 676032001500 ATP binding site [chemical binding]; other site 676032001501 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 676032001502 active site 676032001503 putative metal-binding site [ion binding]; other site 676032001504 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 676032001505 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 676032001506 active site 676032001507 multimer interface [polypeptide binding]; other site 676032001508 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 676032001509 predicted active site [active] 676032001510 catalytic triad [active] 676032001511 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 676032001512 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 676032001513 DNA binding site [nucleotide binding] 676032001514 catalytic residue [active] 676032001515 H2TH interface [polypeptide binding]; other site 676032001516 putative catalytic residues [active] 676032001517 turnover-facilitating residue; other site 676032001518 intercalation triad [nucleotide binding]; other site 676032001519 8OG recognition residue [nucleotide binding]; other site 676032001520 putative reading head residues; other site 676032001521 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 676032001522 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 676032001523 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 676032001524 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 676032001525 acyl-activating enzyme (AAE) consensus motif; other site 676032001526 putative AMP binding site [chemical binding]; other site 676032001527 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 676032001528 Cell division protein FtsL; Region: FtsL; cl11433 676032001529 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 676032001530 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 676032001531 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 676032001532 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 676032001533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 676032001534 Transposase, Mutator family; Region: Transposase_mut; cl19537 676032001535 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 676032001536 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 676032001537 16S/18S rRNA binding site [nucleotide binding]; other site 676032001538 S13e-L30e interaction site [polypeptide binding]; other site 676032001539 25S rRNA binding site [nucleotide binding]; other site 676032001540 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 676032001541 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 676032001542 RNase E interface [polypeptide binding]; other site 676032001543 trimer interface [polypeptide binding]; other site 676032001544 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 676032001545 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 676032001546 RNase E interface [polypeptide binding]; other site 676032001547 trimer interface [polypeptide binding]; other site 676032001548 active site 676032001549 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 676032001550 putative nucleic acid binding region [nucleotide binding]; other site 676032001551 G-X-X-G motif; other site 676032001552 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 676032001553 RNA binding site [nucleotide binding]; other site 676032001554 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 676032001555 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 676032001556 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 676032001557 ATP-binding site [chemical binding]; other site 676032001558 Sugar specificity; other site 676032001559 Pyrimidine base specificity; other site 676032001560 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 676032001561 TRAM domain; Region: TRAM; cl01282 676032001562 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 676032001563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032001564 S-adenosylmethionine binding site [chemical binding]; other site 676032001565 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 676032001566 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 676032001567 nucleotide binding site [chemical binding]; other site 676032001568 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 676032001569 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 676032001570 nucleotide binding site [chemical binding]; other site 676032001571 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 676032001572 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032001573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001574 putative substrate translocation pore; other site 676032001575 enolase; Provisional; Region: eno; PRK00077 676032001576 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 676032001577 dimer interface [polypeptide binding]; other site 676032001578 metal binding site [ion binding]; metal-binding site 676032001579 substrate binding pocket [chemical binding]; other site 676032001580 Septum formation initiator; Region: DivIC; cl17659 676032001581 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 676032001582 substrate binding site; other site 676032001583 dimer interface; other site 676032001584 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 676032001585 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 676032001586 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 676032001587 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 676032001588 NAD(P) binding site [chemical binding]; other site 676032001589 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 676032001590 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 676032001591 substrate-cofactor binding pocket; other site 676032001592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032001593 catalytic residue [active] 676032001594 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 676032001595 Glyco_18 domain; Region: Glyco_18; smart00636 676032001596 active site 676032001597 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 676032001598 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 676032001599 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 676032001600 aromatic chitin/cellulose binding site residues [chemical binding]; other site 676032001601 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 676032001602 aromatic chitin/cellulose binding site residues [chemical binding]; other site 676032001603 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 676032001604 aromatic chitin/cellulose binding site residues [chemical binding]; other site 676032001605 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 676032001606 active site 676032001607 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 676032001608 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 676032001609 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 676032001610 active site 676032001611 substrate binding site [chemical binding]; other site 676032001612 cosubstrate binding site; other site 676032001613 catalytic site [active] 676032001614 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 676032001615 putative substrate binding pocket [chemical binding]; other site 676032001616 trimer interface [polypeptide binding]; other site 676032001617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001618 metabolite-proton symporter; Region: 2A0106; TIGR00883 676032001619 putative substrate translocation pore; other site 676032001620 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 676032001621 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 676032001622 Zn2+ binding site [ion binding]; other site 676032001623 Mg2+ binding site [ion binding]; other site 676032001624 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 676032001625 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 676032001626 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 676032001627 dimer interface [polypeptide binding]; other site 676032001628 active site 676032001629 heme binding site [chemical binding]; other site 676032001630 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 676032001631 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 676032001632 active site 676032001633 purine riboside binding site [chemical binding]; other site 676032001634 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 676032001635 classical (c) SDRs; Region: SDR_c; cd05233 676032001636 NAD(P) binding site [chemical binding]; other site 676032001637 active site 676032001638 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 676032001639 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 676032001640 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 676032001641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001642 putative substrate translocation pore; other site 676032001643 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 676032001644 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 676032001645 active site 676032001646 catalytic site [active] 676032001647 metal binding site [ion binding]; metal-binding site 676032001648 HlyD family secretion protein; Region: HlyD_3; pfam13437 676032001649 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 676032001650 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 676032001651 Walker A/P-loop; other site 676032001652 ATP binding site [chemical binding]; other site 676032001653 Q-loop/lid; other site 676032001654 ABC transporter signature motif; other site 676032001655 Walker B; other site 676032001656 D-loop; other site 676032001657 H-loop/switch region; other site 676032001658 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 676032001659 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 676032001660 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 676032001661 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 676032001662 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 676032001663 Sulfate transporter family; Region: Sulfate_transp; pfam00916 676032001664 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 676032001665 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 676032001666 homotrimer interaction site [polypeptide binding]; other site 676032001667 putative active site [active] 676032001668 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 676032001669 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 676032001670 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 676032001671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 676032001672 Walker A/P-loop; other site 676032001673 ATP binding site [chemical binding]; other site 676032001674 Q-loop/lid; other site 676032001675 ABC transporter signature motif; other site 676032001676 Walker B; other site 676032001677 D-loop; other site 676032001678 H-loop/switch region; other site 676032001679 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 676032001680 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 676032001681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 676032001682 Walker A/P-loop; other site 676032001683 ATP binding site [chemical binding]; other site 676032001684 Q-loop/lid; other site 676032001685 ABC transporter signature motif; other site 676032001686 Walker B; other site 676032001687 D-loop; other site 676032001688 H-loop/switch region; other site 676032001689 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 676032001690 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 676032001691 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 676032001692 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 676032001693 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 676032001694 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 676032001695 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 676032001696 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 676032001697 seryl-tRNA synthetase; Provisional; Region: PRK05431 676032001698 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 676032001699 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 676032001700 dimer interface [polypeptide binding]; other site 676032001701 active site 676032001702 motif 1; other site 676032001703 motif 2; other site 676032001704 motif 3; other site 676032001705 phosphoglyceromutase; Provisional; Region: PRK05434 676032001706 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 676032001707 FAD binding domain; Region: FAD_binding_4; pfam01565 676032001708 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 676032001709 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 676032001710 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 676032001711 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 676032001712 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 676032001713 active site 676032001714 catalytic motif [active] 676032001715 Zn binding site [ion binding]; other site 676032001716 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 676032001717 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 676032001718 active site 676032001719 dinuclear metal binding site [ion binding]; other site 676032001720 dimerization interface [polypeptide binding]; other site 676032001721 Predicted membrane protein [Function unknown]; Region: COG2860 676032001722 UPF0126 domain; Region: UPF0126; pfam03458 676032001723 UPF0126 domain; Region: UPF0126; pfam03458 676032001724 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 676032001725 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 676032001726 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 676032001727 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 676032001728 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 676032001729 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 676032001730 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 676032001731 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 676032001732 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 676032001733 multifunctional aminopeptidase A; Provisional; Region: PRK00913 676032001734 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 676032001735 interface (dimer of trimers) [polypeptide binding]; other site 676032001736 Substrate-binding/catalytic site; other site 676032001737 Zn-binding sites [ion binding]; other site 676032001738 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 676032001739 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 676032001740 active site 676032001741 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 676032001742 Thiamine pyrophosphokinase; Region: TPK; cd07995 676032001743 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 676032001744 active site 676032001745 dimerization interface [polypeptide binding]; other site 676032001746 thiamine binding site [chemical binding]; other site 676032001747 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 676032001748 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 676032001749 active site 676032001750 dimer interface [polypeptide binding]; other site 676032001751 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 676032001752 dimer interface [polypeptide binding]; other site 676032001753 active site 676032001754 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 676032001755 Type II transport protein GspH; Region: GspH; pfam12019 676032001756 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 676032001757 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 676032001758 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 676032001759 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 676032001760 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 676032001761 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 676032001762 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 676032001763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001764 putative transporter; Provisional; Region: PRK10504 676032001765 putative substrate translocation pore; other site 676032001766 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 676032001767 FtsH Extracellular; Region: FtsH_ext; pfam06480 676032001768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 676032001769 Walker A motif; other site 676032001770 ATP binding site [chemical binding]; other site 676032001771 Walker B motif; other site 676032001772 arginine finger; other site 676032001773 Peptidase family M41; Region: Peptidase_M41; pfam01434 676032001774 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 676032001775 LPP20 lipoprotein; Region: LPP20; pfam02169 676032001776 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 676032001777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 676032001778 ATP binding site [chemical binding]; other site 676032001779 putative Mg++ binding site [ion binding]; other site 676032001780 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 676032001781 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 676032001782 SEC-C motif; Region: SEC-C; pfam02810 676032001783 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 676032001784 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 676032001785 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 676032001786 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 676032001787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001788 putative substrate translocation pore; other site 676032001789 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 676032001790 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 676032001791 catalytic site [active] 676032001792 putative active site [active] 676032001793 putative substrate binding site [chemical binding]; other site 676032001794 HRDC domain; Region: HRDC; pfam00570 676032001795 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 676032001796 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 676032001797 GIY-YIG motif/motif A; other site 676032001798 active site 676032001799 catalytic site [active] 676032001800 putative DNA binding site [nucleotide binding]; other site 676032001801 metal binding site [ion binding]; metal-binding site 676032001802 UvrB/uvrC motif; Region: UVR; pfam02151 676032001803 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 676032001804 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 676032001805 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 676032001806 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 676032001807 active site 676032001808 Uncharacterized conserved protein [Function unknown]; Region: COG2835 676032001809 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 676032001810 Ligand binding site; other site 676032001811 oligomer interface; other site 676032001812 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 676032001813 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 676032001814 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 676032001815 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 676032001816 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 676032001817 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 676032001818 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 676032001819 dimer interface [polypeptide binding]; other site 676032001820 active site 676032001821 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 676032001822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001823 putative substrate translocation pore; other site 676032001824 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 676032001825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001826 putative substrate translocation pore; other site 676032001827 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 676032001828 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 676032001829 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 676032001830 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 676032001831 ATP binding site [chemical binding]; other site 676032001832 Mg++ binding site [ion binding]; other site 676032001833 motif III; other site 676032001834 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 676032001835 nucleotide binding region [chemical binding]; other site 676032001836 ATP-binding site [chemical binding]; other site 676032001837 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 676032001838 putative RNA binding site [nucleotide binding]; other site 676032001839 Guanylate kinase; Region: Guanylate_kin; pfam00625 676032001840 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 676032001841 catalytic site [active] 676032001842 G-X2-G-X-G-K; other site 676032001843 quinolinate synthetase; Provisional; Region: PRK09375 676032001844 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 676032001845 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 676032001846 dimerization interface [polypeptide binding]; other site 676032001847 active site 676032001848 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 676032001849 L-aspartate oxidase; Provisional; Region: PRK06175 676032001850 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 676032001851 RmuC family; Region: RmuC; pfam02646 676032001852 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 676032001853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 676032001854 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 676032001855 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 676032001856 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 676032001857 catalytic residue [active] 676032001858 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 676032001859 Zn2+ binding site [ion binding]; other site 676032001860 intersubunit interface [polypeptide binding]; other site 676032001861 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 676032001862 active site 676032001863 DNA binding site [nucleotide binding] 676032001864 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 676032001865 catalytic triad [active] 676032001866 conserved cis-peptide bond; other site 676032001867 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 676032001868 catalytic triad [active] 676032001869 conserved cis-peptide bond; other site 676032001870 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 676032001871 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 676032001872 dimer interface [polypeptide binding]; other site 676032001873 metal binding site [ion binding]; metal-binding site 676032001874 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 676032001875 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 676032001876 Mechanosensitive ion channel; Region: MS_channel; pfam00924 676032001877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001878 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032001879 putative substrate translocation pore; other site 676032001880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032001881 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032001882 putative substrate translocation pore; other site 676032001883 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 676032001884 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 676032001885 putative active site [active] 676032001886 Zn binding site [ion binding]; other site 676032001887 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 676032001888 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 676032001889 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 676032001890 active site 676032001891 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 676032001892 5S rRNA interface [nucleotide binding]; other site 676032001893 CTC domain interface [polypeptide binding]; other site 676032001894 L16 interface [polypeptide binding]; other site 676032001895 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 676032001896 Domain of unknown function DUF21; Region: DUF21; pfam01595 676032001897 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 676032001898 Transporter associated domain; Region: CorC_HlyC; pfam03471 676032001899 GTP-binding protein YchF; Reviewed; Region: PRK09601 676032001900 YchF GTPase; Region: YchF; cd01900 676032001901 G1 box; other site 676032001902 GTP/Mg2+ binding site [chemical binding]; other site 676032001903 Switch I region; other site 676032001904 G2 box; other site 676032001905 Switch II region; other site 676032001906 G3 box; other site 676032001907 G4 box; other site 676032001908 G5 box; other site 676032001909 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 676032001910 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 676032001911 putative active site [active] 676032001912 catalytic residue [active] 676032001913 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 676032001914 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 676032001915 dimerization domain [polypeptide binding]; other site 676032001916 dimer interface [polypeptide binding]; other site 676032001917 catalytic residues [active] 676032001918 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 676032001919 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 676032001920 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 676032001921 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 676032001922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 676032001923 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 676032001924 Ion channel; Region: Ion_trans_2; pfam07885 676032001925 TrkA-N domain; Region: TrkA_N; pfam02254 676032001926 POT family; Region: PTR2; cl17359 676032001927 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 676032001928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 676032001929 Walker A motif; other site 676032001930 ATP binding site [chemical binding]; other site 676032001931 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 676032001932 Walker B motif; other site 676032001933 arginine finger; other site 676032001934 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 676032001935 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 676032001936 active site 676032001937 HslU subunit interaction site [polypeptide binding]; other site 676032001938 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 676032001939 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 676032001940 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 676032001941 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 676032001942 active site 676032001943 HIGH motif; other site 676032001944 dimer interface [polypeptide binding]; other site 676032001945 KMSKS motif; other site 676032001946 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 676032001947 RNA binding surface [nucleotide binding]; other site 676032001948 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 676032001949 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 676032001950 active site 676032001951 substrate binding site [chemical binding]; other site 676032001952 FMN binding site [chemical binding]; other site 676032001953 putative catalytic residues [active] 676032001954 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 676032001955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032001956 S-adenosylmethionine binding site [chemical binding]; other site 676032001957 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 676032001958 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 676032001959 FMN binding site [chemical binding]; other site 676032001960 active site 676032001961 catalytic residues [active] 676032001962 substrate binding site [chemical binding]; other site 676032001963 Chorismate mutase type II; Region: CM_2; smart00830 676032001964 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 676032001965 catalytic residues [active] 676032001966 dimer interface [polypeptide binding]; other site 676032001967 Protein of unknown function (DUF819); Region: DUF819; cl02317 676032001968 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 676032001969 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 676032001970 active site 676032001971 Putative serine esterase (DUF676); Region: DUF676; pfam05057 676032001972 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 676032001973 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 676032001974 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 676032001975 putative substrate binding site [chemical binding]; other site 676032001976 putative ATP binding site [chemical binding]; other site 676032001977 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 676032001978 RNA binding surface [nucleotide binding]; other site 676032001979 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 676032001980 OstA-like protein; Region: OstA; cl00844 676032001981 Organic solvent tolerance protein; Region: OstA_C; pfam04453 676032001982 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 676032001983 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 676032001984 Fusaric acid resistance protein family; Region: FUSC; pfam04632 676032001985 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 676032001986 multidrug resistance protein MdtN; Provisional; Region: PRK10476 676032001987 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 676032001988 HlyD family secretion protein; Region: HlyD_3; pfam13437 676032001989 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 676032001990 Transcriptional regulator [Transcription]; Region: IclR; COG1414 676032001991 Bacterial transcriptional regulator; Region: IclR; pfam01614 676032001992 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 676032001993 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 676032001994 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 676032001995 KamA family protein; Region: TIGR00238; cl15377 676032001996 Radical SAM superfamily; Region: Radical_SAM; pfam04055 676032001997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 676032001998 FeS/SAM binding site; other site 676032001999 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 676032002000 ParB-like nuclease domain; Region: ParB; smart00470 676032002001 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 676032002002 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 676032002003 putative efflux protein, MATE family; Region: matE; TIGR00797 676032002004 cysteine synthase; Region: PLN02565 676032002005 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 676032002006 dimer interface [polypeptide binding]; other site 676032002007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032002008 catalytic residue [active] 676032002009 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 676032002010 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 676032002011 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 676032002012 catalytic residue [active] 676032002013 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 676032002014 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 676032002015 integrase; Provisional; Region: PRK09692 676032002016 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 676032002017 active site 676032002018 Int/Topo IB signature motif; other site 676032002019 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 676032002020 AAA domain; Region: AAA_25; pfam13481 676032002021 Walker A motif; other site 676032002022 ATP binding site [chemical binding]; other site 676032002023 Walker B motif; other site 676032002024 Winged helix-turn helix; Region: HTH_29; pfam13551 676032002025 Helix-turn-helix domain; Region: HTH_28; pfam13518 676032002026 Homeodomain-like domain; Region: HTH_32; pfam13565 676032002027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 676032002028 Integrase core domain; Region: rve; pfam00665 676032002029 Integrase core domain; Region: rve_3; pfam13683 676032002030 Rhomboid family; Region: Rhomboid; cl11446 676032002031 Domain of unknown function DUF87; Region: DUF87; cl19135 676032002032 AAA-like domain; Region: AAA_10; pfam12846 676032002033 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 676032002034 Antirestriction protein (ArdA); Region: ArdA; pfam07275 676032002035 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 676032002036 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 676032002037 HsdM N-terminal domain; Region: HsdM_N; pfam12161 676032002038 Methyltransferase domain; Region: Methyltransf_26; pfam13659 676032002039 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 676032002040 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 676032002041 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 676032002042 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 676032002043 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 676032002044 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 676032002045 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 676032002046 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 676032002047 ATP binding site [chemical binding]; other site 676032002048 putative Mg++ binding site [ion binding]; other site 676032002049 Protein of unknown function DUF45; Region: DUF45; pfam01863 676032002050 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 676032002051 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 676032002052 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 676032002053 active site 676032002054 tetramer interface; other site 676032002055 acetyl-CoA synthetase; Provisional; Region: PRK00174 676032002056 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 676032002057 active site 676032002058 CoA binding site [chemical binding]; other site 676032002059 acyl-activating enzyme (AAE) consensus motif; other site 676032002060 AMP binding site [chemical binding]; other site 676032002061 acetate binding site [chemical binding]; other site 676032002062 EamA-like transporter family; Region: EamA; pfam00892 676032002063 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 676032002064 EamA-like transporter family; Region: EamA; pfam00892 676032002065 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 676032002066 recombination protein F; Reviewed; Region: recF; PRK00064 676032002067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 676032002068 Walker A/P-loop; other site 676032002069 ATP binding site [chemical binding]; other site 676032002070 Q-loop/lid; other site 676032002071 ABC transporter signature motif; other site 676032002072 Walker B; other site 676032002073 D-loop; other site 676032002074 H-loop/switch region; other site 676032002075 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 676032002076 active site 676032002077 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 676032002078 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 676032002079 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 676032002080 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952 676032002081 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 676032002082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 676032002083 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 676032002084 NAD(P) binding site [chemical binding]; other site 676032002085 active site 676032002086 PRC-barrel domain; Region: PRC; pfam05239 676032002087 DNA photolyase; Region: DNA_photolyase; pfam00875 676032002088 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 676032002089 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 676032002090 Ferrochelatase; Region: Ferrochelatase; pfam00762 676032002091 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 676032002092 C-terminal domain interface [polypeptide binding]; other site 676032002093 active site 676032002094 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 676032002095 active site 676032002096 N-terminal domain interface [polypeptide binding]; other site 676032002097 Predicted ATPase [General function prediction only]; Region: COG4637 676032002098 AAA domain; Region: AAA_21; pfam13304 676032002099 Walker A/P-loop; other site 676032002100 ATP binding site [chemical binding]; other site 676032002101 AAA domain; Region: AAA_21; pfam13304 676032002102 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 676032002103 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 676032002104 Succinate dehydrogenase/Fumarate reductase transmembrane subunit; Region: Sdh_cyt; pfam01127 676032002105 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 676032002106 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 676032002107 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 676032002108 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 676032002109 Walker A motif; other site 676032002110 ATP binding site [chemical binding]; other site 676032002111 Walker B motif; other site 676032002112 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 676032002113 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 676032002114 active site 676032002115 catalytic site [active] 676032002116 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 676032002117 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 676032002118 putative MPT binding site; other site 676032002119 cyanophycin synthetase; Provisional; Region: PRK14016 676032002120 ATP-grasp domain; Region: ATP-grasp_4; cl17255 676032002121 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 676032002122 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 676032002123 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 676032002124 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 676032002125 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 676032002126 homotrimer interaction site [polypeptide binding]; other site 676032002127 zinc binding site [ion binding]; other site 676032002128 CDP-binding sites; other site 676032002129 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 676032002130 active site residue [active] 676032002131 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 676032002132 active site residue [active] 676032002133 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 676032002134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 676032002135 putative PBP binding loops; other site 676032002136 dimer interface [polypeptide binding]; other site 676032002137 ABC-ATPase subunit interface; other site 676032002138 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 676032002139 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 676032002140 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 676032002141 Walker A/P-loop; other site 676032002142 ATP binding site [chemical binding]; other site 676032002143 Q-loop/lid; other site 676032002144 ABC transporter signature motif; other site 676032002145 Walker B; other site 676032002146 D-loop; other site 676032002147 H-loop/switch region; other site 676032002148 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 676032002149 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 676032002150 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 676032002151 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 676032002152 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 676032002153 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 676032002154 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 676032002155 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 676032002156 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 676032002157 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 676032002158 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 676032002159 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 676032002160 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 676032002161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 676032002162 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 676032002163 dimerization interface [polypeptide binding]; other site 676032002164 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 676032002165 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 676032002166 catalytic triad [active] 676032002167 conserved cis-peptide bond; other site 676032002168 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 676032002169 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 676032002170 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 676032002171 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 676032002172 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 676032002173 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 676032002174 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 676032002175 Protein export membrane protein; Region: SecD_SecF; pfam02355 676032002176 Src Homology 3 domain superfamily; Region: SH3; cl17036 676032002177 peptide ligand binding site [polypeptide binding]; other site 676032002178 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 676032002179 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 676032002180 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 676032002181 DNA binding residues [nucleotide binding] 676032002182 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 676032002183 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 676032002184 hinge; other site 676032002185 active site 676032002186 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 676032002187 RNA/DNA hybrid binding site [nucleotide binding]; other site 676032002188 active site 676032002189 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 676032002190 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 676032002191 active site 676032002192 homodimer interface [polypeptide binding]; other site 676032002193 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 676032002194 active site clefts [active] 676032002195 zinc binding site [ion binding]; other site 676032002196 dimer interface [polypeptide binding]; other site 676032002197 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 676032002198 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 676032002199 catalytic residue [active] 676032002200 Rubredoxin [Energy production and conversion]; Region: COG1773 676032002201 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 676032002202 iron binding site [ion binding]; other site 676032002203 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; cl19499 676032002204 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 676032002205 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 676032002206 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 676032002207 dimer interface [polypeptide binding]; other site 676032002208 active site 676032002209 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 676032002210 dimer interface [polypeptide binding]; other site 676032002211 active site 676032002212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032002213 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 676032002214 putative substrate translocation pore; other site 676032002215 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 676032002216 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 676032002217 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 676032002218 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 676032002219 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 676032002220 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 676032002221 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 676032002222 active site 676032002223 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 676032002224 active site 676032002225 substrate binding site [chemical binding]; other site 676032002226 Mg2+ binding site [ion binding]; other site 676032002227 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 676032002228 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 676032002229 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 676032002230 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 676032002231 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 676032002232 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 676032002233 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 676032002234 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 676032002235 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 676032002236 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 676032002237 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 676032002238 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 676032002239 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 676032002240 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 676032002241 VirK protein; Region: VirK; pfam06903 676032002242 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 676032002243 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 676032002244 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 676032002245 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 676032002246 putative active site [active] 676032002247 catalytic triad [active] 676032002248 putative dimer interface [polypeptide binding]; other site 676032002249 FOG: CBS domain [General function prediction only]; Region: COG0517 676032002250 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 676032002251 Transporter associated domain; Region: CorC_HlyC; smart01091 676032002252 metal-binding heat shock protein; Provisional; Region: PRK00016 676032002253 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 676032002254 PhoH-like protein; Region: PhoH; pfam02562 676032002255 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 676032002256 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 676032002257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 676032002258 FeS/SAM binding site; other site 676032002259 TRAM domain; Region: TRAM; pfam01938 676032002260 Methyltransferase domain; Region: Methyltransf_31; pfam13847 676032002261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032002262 S-adenosylmethionine binding site [chemical binding]; other site 676032002263 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 676032002264 thymidine kinase; Provisional; Region: PRK04296 676032002265 trigger factor; Provisional; Region: tig; PRK01490 676032002266 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 676032002267 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 676032002268 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 676032002269 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 676032002270 oligomer interface [polypeptide binding]; other site 676032002271 active site residues [active] 676032002272 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 676032002273 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 676032002274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 676032002275 Walker A motif; other site 676032002276 ATP binding site [chemical binding]; other site 676032002277 Walker B motif; other site 676032002278 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 676032002279 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 676032002280 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 676032002281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 676032002282 Walker A motif; other site 676032002283 ATP binding site [chemical binding]; other site 676032002284 Walker B motif; other site 676032002285 arginine finger; other site 676032002286 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 676032002287 histone-like DNA-binding protein HU; Region: HU; cd13831 676032002288 dimer interface [polypeptide binding]; other site 676032002289 DNA binding site [nucleotide binding] 676032002290 SurA N-terminal domain; Region: SurA_N_2; pfam13623 676032002291 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 676032002292 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 676032002293 bacterial Hfq-like; Region: Hfq; cd01716 676032002294 hexamer interface [polypeptide binding]; other site 676032002295 Sm1 motif; other site 676032002296 RNA binding site [nucleotide binding]; other site 676032002297 Sm2 motif; other site 676032002298 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 676032002299 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 676032002300 HflX GTPase family; Region: HflX; cd01878 676032002301 G1 box; other site 676032002302 GTP/Mg2+ binding site [chemical binding]; other site 676032002303 Switch I region; other site 676032002304 G2 box; other site 676032002305 G3 box; other site 676032002306 Switch II region; other site 676032002307 G4 box; other site 676032002308 G5 box; other site 676032002309 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 676032002310 hypothetical protein; Provisional; Region: PRK07588 676032002311 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 676032002312 HflK protein; Region: hflK; TIGR01933 676032002313 HflC protein; Region: hflC; TIGR01932 676032002314 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 676032002315 Low molecular weight phosphatase family; Region: LMWPc; cd00115 676032002316 active site 676032002317 Predicted GTPase [General function prediction only]; Region: COG0218 676032002318 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 676032002319 G1 box; other site 676032002320 GTP/Mg2+ binding site [chemical binding]; other site 676032002321 Switch I region; other site 676032002322 G2 box; other site 676032002323 G3 box; other site 676032002324 Switch II region; other site 676032002325 G4 box; other site 676032002326 G5 box; other site 676032002327 threonine synthase; Validated; Region: PRK06450 676032002328 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 676032002329 homodimer interface [polypeptide binding]; other site 676032002330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032002331 catalytic residue [active] 676032002332 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 676032002333 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 676032002334 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 676032002335 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 676032002336 PYR/PP interface [polypeptide binding]; other site 676032002337 dimer interface [polypeptide binding]; other site 676032002338 TPP binding site [chemical binding]; other site 676032002339 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 676032002340 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 676032002341 TPP-binding site [chemical binding]; other site 676032002342 dimer interface [polypeptide binding]; other site 676032002343 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 676032002344 putative valine binding site [chemical binding]; other site 676032002345 dimer interface [polypeptide binding]; other site 676032002346 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 676032002347 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 676032002348 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 676032002349 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 676032002350 active site 676032002351 metal-binding site [ion binding] 676032002352 AAA domain; Region: AAA_18; pfam13238 676032002353 nucleotide-binding site [chemical binding]; other site 676032002354 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; cl19204 676032002355 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 676032002356 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 676032002357 Ligand Binding Site [chemical binding]; other site 676032002358 Molecular Tunnel; other site 676032002359 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 676032002360 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 676032002361 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 676032002362 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 676032002363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 676032002364 Walker A/P-loop; other site 676032002365 ATP binding site [chemical binding]; other site 676032002366 Q-loop/lid; other site 676032002367 ABC transporter signature motif; other site 676032002368 Walker B; other site 676032002369 D-loop; other site 676032002370 H-loop/switch region; other site 676032002371 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 676032002372 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 676032002373 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 676032002374 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 676032002375 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 676032002376 Active Sites [active] 676032002377 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 676032002378 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 676032002379 CysD dimerization site [polypeptide binding]; other site 676032002380 G1 box; other site 676032002381 putative GEF interaction site [polypeptide binding]; other site 676032002382 GTP/Mg2+ binding site [chemical binding]; other site 676032002383 Switch I region; other site 676032002384 G2 box; other site 676032002385 G3 box; other site 676032002386 Switch II region; other site 676032002387 G4 box; other site 676032002388 G5 box; other site 676032002389 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 676032002390 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 676032002391 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 676032002392 ligand-binding site [chemical binding]; other site 676032002393 PQ loop repeat; Region: PQ-loop; pfam04193 676032002394 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 676032002395 substrate binding pocket [chemical binding]; other site 676032002396 chain length determination region; other site 676032002397 substrate-Mg2+ binding site; other site 676032002398 catalytic residues [active] 676032002399 aspartate-rich region 1; other site 676032002400 active site lid residues [active] 676032002401 aspartate-rich region 2; other site 676032002402 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 676032002403 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 676032002404 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 676032002405 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 676032002406 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 676032002407 Ligand Binding Site [chemical binding]; other site 676032002408 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 676032002409 active site 676032002410 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 676032002411 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 676032002412 N-acetyl-D-glucosamine binding site [chemical binding]; other site 676032002413 catalytic residue [active] 676032002414 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 676032002415 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 676032002416 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 676032002417 Yqey-like protein; Region: YqeY; pfam09424 676032002418 CHC2 zinc finger; Region: zf-CHC2; pfam01807 676032002419 DNA primase; Validated; Region: dnaG; PRK05667 676032002420 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 676032002421 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 676032002422 active site 676032002423 metal binding site [ion binding]; metal-binding site 676032002424 interdomain interaction site; other site 676032002425 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 676032002426 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 676032002427 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 676032002428 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 676032002429 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 676032002430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 676032002431 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 676032002432 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 676032002433 DNA binding residues [nucleotide binding] 676032002434 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 676032002435 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 676032002436 alpha-glucosidase; Provisional; Region: PRK10426 676032002437 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 676032002438 putative active site [active] 676032002439 putative catalytic site [active] 676032002440 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 676032002441 putative symporter YagG; Provisional; Region: PRK09669; cl15392 676032002442 lipoate-protein ligase B; Provisional; Region: PRK14342 676032002443 Protein of unknown function (DUF493); Region: DUF493; pfam04359 676032002444 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 676032002445 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 676032002446 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 676032002447 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 676032002448 dimer interface [polypeptide binding]; other site 676032002449 substrate binding site [chemical binding]; other site 676032002450 metal binding sites [ion binding]; metal-binding site 676032002451 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 676032002452 active site 676032002453 motif I; other site 676032002454 motif II; other site 676032002455 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 676032002456 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 676032002457 OstA-like protein; Region: OstA; cl00844 676032002458 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 676032002459 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 676032002460 Walker A/P-loop; other site 676032002461 ATP binding site [chemical binding]; other site 676032002462 Q-loop/lid; other site 676032002463 ABC transporter signature motif; other site 676032002464 Walker B; other site 676032002465 D-loop; other site 676032002466 H-loop/switch region; other site 676032002467 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 676032002468 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 676032002469 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 676032002470 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 676032002471 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 676032002472 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 676032002473 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 676032002474 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 676032002475 dimerization interface 3.5A [polypeptide binding]; other site 676032002476 active site 676032002477 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 676032002478 GMP synthase; Reviewed; Region: guaA; PRK00074 676032002479 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 676032002480 AMP/PPi binding site [chemical binding]; other site 676032002481 candidate oxyanion hole; other site 676032002482 catalytic triad [active] 676032002483 potential glutamine specificity residues [chemical binding]; other site 676032002484 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 676032002485 ATP Binding subdomain [chemical binding]; other site 676032002486 Ligand Binding sites [chemical binding]; other site 676032002487 Dimerization subdomain; other site 676032002488 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 676032002489 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 676032002490 TPP-binding site; other site 676032002491 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 676032002492 PYR/PP interface [polypeptide binding]; other site 676032002493 dimer interface [polypeptide binding]; other site 676032002494 TPP binding site [chemical binding]; other site 676032002495 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 676032002496 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 676032002497 active site 676032002498 catalytic triad [active] 676032002499 oxyanion hole [active] 676032002500 switch loop; other site 676032002501 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 676032002502 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 676032002503 classical (c) SDRs; Region: SDR_c; cd05233 676032002504 NAD(P) binding site [chemical binding]; other site 676032002505 active site 676032002506 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 676032002507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 676032002508 Walker A motif; other site 676032002509 ATP binding site [chemical binding]; other site 676032002510 Walker B motif; other site 676032002511 arginine finger; other site 676032002512 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 676032002513 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 676032002514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 676032002515 non-specific DNA binding site [nucleotide binding]; other site 676032002516 salt bridge; other site 676032002517 sequence-specific DNA binding site [nucleotide binding]; other site 676032002518 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 676032002519 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 676032002520 catalytic motif [active] 676032002521 Catalytic residue [active] 676032002522 Aspartyl protease; Region: Asp_protease_2; pfam13650 676032002523 inhibitor binding site; inhibition site 676032002524 catalytic motif [active] 676032002525 Catalytic residue [active] 676032002526 Active site flap [active] 676032002527 putative symporter YagG; Provisional; Region: PRK09669; cl15392 676032002528 MFS/sugar transport protein; Region: MFS_2; pfam13347 676032002529 Family of unknown function (DUF706); Region: DUF706; pfam05153 676032002530 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 676032002531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032002532 putative substrate translocation pore; other site 676032002533 glucuronate isomerase; Reviewed; Region: PRK02925 676032002534 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 676032002535 active site 676032002536 intersubunit interface [polypeptide binding]; other site 676032002537 catalytic residue [active] 676032002538 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 676032002539 substrate binding site [chemical binding]; other site 676032002540 ATP binding site [chemical binding]; other site 676032002541 mannonate dehydratase; Provisional; Region: PRK03906 676032002542 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 676032002543 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 676032002544 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 676032002545 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 676032002546 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 676032002547 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 676032002548 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 676032002549 putative active site [active] 676032002550 putative catalytic site [active] 676032002551 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 676032002552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032002553 putative substrate translocation pore; other site 676032002554 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 676032002555 POT family; Region: PTR2; cl17359 676032002556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032002557 putative substrate translocation pore; other site 676032002558 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 676032002559 EamA-like transporter family; Region: EamA; pfam00892 676032002560 EamA-like transporter family; Region: EamA; pfam00892 676032002561 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 676032002562 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 676032002563 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 676032002564 dimer interface [polypeptide binding]; other site 676032002565 motif 1; other site 676032002566 active site 676032002567 motif 2; other site 676032002568 motif 3; other site 676032002569 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 676032002570 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 676032002571 putative tRNA-binding site [nucleotide binding]; other site 676032002572 B3/4 domain; Region: B3_4; pfam03483 676032002573 tRNA synthetase B5 domain; Region: B5; smart00874 676032002574 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 676032002575 dimer interface [polypeptide binding]; other site 676032002576 motif 1; other site 676032002577 motif 3; other site 676032002578 motif 2; other site 676032002579 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 676032002580 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 676032002581 metal binding site 2 [ion binding]; metal-binding site 676032002582 putative DNA binding helix; other site 676032002583 metal binding site 1 [ion binding]; metal-binding site 676032002584 dimer interface [polypeptide binding]; other site 676032002585 structural Zn2+ binding site [ion binding]; other site 676032002586 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 676032002587 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 676032002588 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 676032002589 ZIP Zinc transporter; Region: Zip; cl00437 676032002590 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 676032002591 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 676032002592 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 676032002593 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 676032002594 putative active site [active] 676032002595 catalytic site [active] 676032002596 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 676032002597 putative active site [active] 676032002598 catalytic site [active] 676032002599 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 676032002600 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 676032002601 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 676032002602 putative active site [active] 676032002603 catalytic site [active] 676032002604 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 676032002605 putative active site [active] 676032002606 catalytic site [active] 676032002607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032002608 metabolite-proton symporter; Region: 2A0106; TIGR00883 676032002609 putative substrate translocation pore; other site 676032002610 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 676032002611 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 676032002612 Walker A motif; other site 676032002613 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 676032002614 trimer interface [polypeptide binding]; other site 676032002615 active site 676032002616 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 676032002617 Mechanosensitive ion channel; Region: MS_channel; pfam00924 676032002618 Lipopolysaccharide-assembly; Region: LptE; cl01125 676032002619 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 676032002620 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 676032002621 active site 676032002622 HIGH motif; other site 676032002623 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 676032002624 KMSKS motif; other site 676032002625 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 676032002626 tRNA binding surface [nucleotide binding]; other site 676032002627 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 676032002628 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 676032002629 Transglutaminase/protease-like homologues; Region: TGc; smart00460 676032002630 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 676032002631 Sel1-like repeats; Region: SEL1; smart00671 676032002632 Sel1 repeat; Region: Sel1; pfam08238 676032002633 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 676032002634 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 676032002635 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 676032002636 active site 676032002637 8-oxo-dGMP binding site [chemical binding]; other site 676032002638 nudix motif; other site 676032002639 metal binding site [ion binding]; metal-binding site 676032002640 PAS fold; Region: PAS_4; pfam08448 676032002641 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 676032002642 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 676032002643 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 676032002644 catalytic residue [active] 676032002645 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 676032002646 Transcriptional regulators [Transcription]; Region: MarR; COG1846 676032002647 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 676032002648 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 676032002649 catalytic residues [active] 676032002650 Amidinotransferase; Region: Amidinotransf; cl19186 676032002651 FeS assembly protein SufD; Region: sufD; TIGR01981 676032002652 FeS assembly ATPase SufC; Region: sufC; TIGR01978 676032002653 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 676032002654 Walker A/P-loop; other site 676032002655 ATP binding site [chemical binding]; other site 676032002656 Q-loop/lid; other site 676032002657 ABC transporter signature motif; other site 676032002658 Walker B; other site 676032002659 D-loop; other site 676032002660 H-loop/switch region; other site 676032002661 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 676032002662 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 676032002663 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 676032002664 Rrf2 family protein; Region: rrf2_super; TIGR00738 676032002665 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 676032002666 TrkA-N domain; Region: TrkA_N; pfam02254 676032002667 TrkA-C domain; Region: TrkA_C; pfam02080 676032002668 TrkA-N domain; Region: TrkA_N; pfam02254 676032002669 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 676032002670 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 676032002671 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 676032002672 rRNA binding site [nucleotide binding]; other site 676032002673 predicted 30S ribosome binding site; other site 676032002674 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 676032002675 signal recognition particle protein; Provisional; Region: PRK10867 676032002676 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 676032002677 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 676032002678 P loop; other site 676032002679 GTP binding site [chemical binding]; other site 676032002680 Signal peptide binding domain; Region: SRP_SPB; pfam02978 676032002681 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 676032002682 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 676032002683 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 676032002684 potential catalytic triad [active] 676032002685 conserved cys residue [active] 676032002686 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 676032002687 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 676032002688 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 676032002689 active site 676032002690 Zn binding site [ion binding]; other site 676032002691 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 676032002692 putative active site [active] 676032002693 putative catalytic site [active] 676032002694 putative DNA binding site [nucleotide binding]; other site 676032002695 putative phosphate binding site [ion binding]; other site 676032002696 metal binding site A [ion binding]; metal-binding site 676032002697 putative AP binding site [nucleotide binding]; other site 676032002698 putative metal binding site B [ion binding]; other site 676032002699 Nuclease-related domain; Region: NERD; pfam08378 676032002700 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 676032002701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 676032002702 AAA domain; Region: AAA_33; pfam13671 676032002703 AAA domain; Region: AAA_17; cl19128 676032002704 Walker A motif; other site 676032002705 ATP binding site [chemical binding]; other site 676032002706 Walker B motif; other site 676032002707 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 676032002708 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 676032002709 glutathione reductase; Validated; Region: PRK06116 676032002710 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 676032002711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 676032002712 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 676032002713 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 676032002714 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 676032002715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032002716 putative substrate translocation pore; other site 676032002717 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 676032002718 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 676032002719 ATP binding site [chemical binding]; other site 676032002720 Mg++ binding site [ion binding]; other site 676032002721 motif III; other site 676032002722 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 676032002723 nucleotide binding region [chemical binding]; other site 676032002724 ATP-binding site [chemical binding]; other site 676032002725 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 676032002726 active site 676032002727 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 676032002728 putative active site [active] 676032002729 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 676032002730 active site 676032002731 catalytic triad [active] 676032002732 dimer interface [polypeptide binding]; other site 676032002733 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 676032002734 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 676032002735 active site 676032002736 catalytic tetrad [active] 676032002737 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 676032002738 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 676032002739 active site 676032002740 catalytic tetrad [active] 676032002741 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032002742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032002743 putative substrate translocation pore; other site 676032002744 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 676032002745 Glutamine amidotransferase class-I; Region: GATase; pfam00117 676032002746 glutamine binding [chemical binding]; other site 676032002747 catalytic triad [active] 676032002748 aminodeoxychorismate synthase; Provisional; Region: PRK07508 676032002749 chorismate binding enzyme; Region: Chorismate_bind; cl10555 676032002750 Aminotransferase class IV; Region: Aminotran_4; pfam01063 676032002751 substrate-cofactor binding pocket; other site 676032002752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032002753 catalytic residue [active] 676032002754 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 676032002755 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 676032002756 acyl-activating enzyme (AAE) consensus motif; other site 676032002757 AMP binding site [chemical binding]; other site 676032002758 active site 676032002759 CoA binding site [chemical binding]; other site 676032002760 Dihydroneopterin aldolase; Region: FolB; smart00905 676032002761 active site 676032002762 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 676032002763 catalytic center binding site [active] 676032002764 ATP binding site [chemical binding]; other site 676032002765 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 676032002766 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 676032002767 substrate binding pocket [chemical binding]; other site 676032002768 dimer interface [polypeptide binding]; other site 676032002769 inhibitor binding site; inhibition site 676032002770 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 676032002771 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 676032002772 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 676032002773 active site 2 [active] 676032002774 active site 1 [active] 676032002775 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 676032002776 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 676032002777 inhibitor-cofactor binding pocket; inhibition site 676032002778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032002779 catalytic residue [active] 676032002780 biotin synthase; Region: bioB; TIGR00433 676032002781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 676032002782 FeS/SAM binding site; other site 676032002783 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 676032002784 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 676032002785 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 676032002786 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 676032002787 catalytic residue [active] 676032002788 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 676032002789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 676032002790 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 676032002791 AAA domain; Region: AAA_26; pfam13500 676032002792 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 676032002793 dimerization interface [polypeptide binding]; other site 676032002794 putative DNA binding site [nucleotide binding]; other site 676032002795 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 676032002796 putative Zn2+ binding site [ion binding]; other site 676032002797 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 676032002798 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 676032002799 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 676032002800 nucleotide binding site [chemical binding]; other site 676032002801 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 676032002802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032002803 putative substrate translocation pore; other site 676032002804 acetoacetate decarboxylase; Provisional; Region: PRK02265 676032002805 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 676032002806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 676032002807 NAD(P) binding site [chemical binding]; other site 676032002808 active site 676032002809 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 676032002810 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 676032002811 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 676032002812 inhibitor-cofactor binding pocket; inhibition site 676032002813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032002814 catalytic residue [active] 676032002815 glutathione synthetase; Provisional; Region: PRK05246 676032002816 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 676032002817 ATP-grasp domain; Region: ATP-grasp_4; cl17255 676032002818 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 676032002819 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 676032002820 putative active site [active] 676032002821 substrate binding site [chemical binding]; other site 676032002822 putative cosubstrate binding site; other site 676032002823 catalytic site [active] 676032002824 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 676032002825 substrate binding site [chemical binding]; other site 676032002826 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 676032002827 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 676032002828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 676032002829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032002830 S-adenosylmethionine binding site [chemical binding]; other site 676032002831 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 676032002832 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 676032002833 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 676032002834 Phage Tail Protein X; Region: Phage_tail_X; cl02088 676032002835 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 676032002836 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 676032002837 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 676032002838 Phage tail tube protein FII; Region: Phage_tube; cl01390 676032002839 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 676032002840 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 676032002841 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 676032002842 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 676032002843 Phage capsid family; Region: Phage_capsid; pfam05065 676032002844 Phage portal protein, lambda family; Region: Phage_portal_2; cl19378 676032002845 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 676032002846 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 676032002847 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 676032002848 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 676032002849 Baseplate J-like protein; Region: Baseplate_J; cl01294 676032002850 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 676032002851 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 676032002852 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 676032002853 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 676032002854 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 676032002855 active site 676032002856 Int/Topo IB signature motif; other site 676032002857 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 676032002858 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 676032002859 YopX protein; Region: YopX; pfam09643 676032002860 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 676032002861 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 676032002862 DNA-binding transcriptional regulator Cro; Region: P22_Cro; cl18770 676032002863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 676032002864 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 676032002865 non-specific DNA binding site [nucleotide binding]; other site 676032002866 salt bridge; other site 676032002867 sequence-specific DNA binding site [nucleotide binding]; other site 676032002868 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 676032002869 Catalytic site [active] 676032002870 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 676032002871 Bacterial PH domain; Region: bPH_2; pfam03703 676032002872 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 676032002873 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 676032002874 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 676032002875 active site 676032002876 DNA binding site [nucleotide binding] 676032002877 Int/Topo IB signature motif; other site 676032002878 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 676032002879 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 676032002880 HlyD family secretion protein; Region: HlyD_3; pfam13437 676032002881 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 676032002882 putative active site [active] 676032002883 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 676032002884 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 676032002885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 676032002886 Walker A/P-loop; other site 676032002887 ATP binding site [chemical binding]; other site 676032002888 Q-loop/lid; other site 676032002889 ABC transporter signature motif; other site 676032002890 Walker B; other site 676032002891 D-loop; other site 676032002892 H-loop/switch region; other site 676032002893 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 676032002894 nucleophilic elbow; other site 676032002895 catalytic triad; other site 676032002896 hypothetical protein; Provisional; Region: PHA02515 676032002897 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 676032002898 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 676032002899 recombination associated protein; Reviewed; Region: rdgC; PRK00321 676032002900 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 676032002901 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 676032002902 active site residue [active] 676032002903 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 676032002904 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 676032002905 S1 domain; Region: S1_2; pfam13509 676032002906 S1 domain; Region: S1_2; pfam13509 676032002907 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 676032002908 Part of AAA domain; Region: AAA_19; pfam13245 676032002909 AAA domain; Region: AAA_14; pfam13173 676032002910 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 676032002911 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 676032002912 Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893 676032002913 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 676032002914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 676032002915 Coenzyme A binding pocket [chemical binding]; other site 676032002916 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 676032002917 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 676032002918 RNA binding surface [nucleotide binding]; other site 676032002919 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 676032002920 probable active site [active] 676032002921 Tetratricopeptide repeat; Region: TPR_12; pfam13424 676032002922 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 676032002923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 676032002924 FeS/SAM binding site; other site 676032002925 replicative DNA helicase; Region: DnaB; TIGR00665 676032002926 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 676032002927 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 676032002928 Walker A motif; other site 676032002929 ATP binding site [chemical binding]; other site 676032002930 Walker B motif; other site 676032002931 DNA binding loops [nucleotide binding] 676032002932 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 676032002933 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 676032002934 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 676032002935 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 676032002936 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 676032002937 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 676032002938 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 676032002939 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 676032002940 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 676032002941 catalytic residue [active] 676032002942 cytidylate kinase; Provisional; Region: cmk; PRK00023 676032002943 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 676032002944 CMP-binding site; other site 676032002945 The sites determining sugar specificity; other site 676032002946 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 676032002947 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 676032002948 putative NAD(P) binding site [chemical binding]; other site 676032002949 homodimer interface [polypeptide binding]; other site 676032002950 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 676032002951 catalytic triad [active] 676032002952 dimer interface [polypeptide binding]; other site 676032002953 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 676032002954 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 676032002955 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 676032002956 dimerization interface [polypeptide binding]; other site 676032002957 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 676032002958 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 676032002959 putative homodimer interface [polypeptide binding]; other site 676032002960 putative homotetramer interface [polypeptide binding]; other site 676032002961 putative allosteric switch controlling residues; other site 676032002962 putative metal binding site [ion binding]; other site 676032002963 putative homodimer-homodimer interface [polypeptide binding]; other site 676032002964 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 676032002965 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 676032002966 tetrameric interface [polypeptide binding]; other site 676032002967 NAD binding site [chemical binding]; other site 676032002968 catalytic residues [active] 676032002969 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 676032002970 TrkA-N domain; Region: TrkA_N; pfam02254 676032002971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 676032002972 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 676032002973 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 676032002974 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 676032002975 active site 676032002976 catalytic site [active] 676032002977 substrate binding site [chemical binding]; other site 676032002978 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 676032002979 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 676032002980 PhnA protein; Region: PhnA; pfam03831 676032002981 peroxidase; Provisional; Region: PRK15000 676032002982 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 676032002983 dimer interface [polypeptide binding]; other site 676032002984 decamer (pentamer of dimers) interface [polypeptide binding]; other site 676032002985 catalytic triad [active] 676032002986 peroxidatic and resolving cysteines [active] 676032002987 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 676032002988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 676032002989 motif II; other site 676032002990 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 676032002991 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 676032002992 putative ATP binding site [chemical binding]; other site 676032002993 putative substrate interface [chemical binding]; other site 676032002994 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 676032002995 N-acetyl-D-glucosamine binding site [chemical binding]; other site 676032002996 catalytic residue [active] 676032002997 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 676032002998 diiron binding motif [ion binding]; other site 676032002999 malate dehydrogenase; Reviewed; Region: PRK06223 676032003000 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 676032003001 NAD(P) binding site [chemical binding]; other site 676032003002 dimer interface [polypeptide binding]; other site 676032003003 tetramer (dimer of dimers) interface [polypeptide binding]; other site 676032003004 substrate binding site [chemical binding]; other site 676032003005 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 676032003006 Class I ribonucleotide reductase; Region: RNR_I; cd01679 676032003007 active site 676032003008 dimer interface [polypeptide binding]; other site 676032003009 catalytic residues [active] 676032003010 effector binding site; other site 676032003011 R2 peptide binding site; other site 676032003012 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 676032003013 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 676032003014 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 676032003015 GSH binding site [chemical binding]; other site 676032003016 catalytic residues [active] 676032003017 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 676032003018 dimer interface [polypeptide binding]; other site 676032003019 putative radical transfer pathway; other site 676032003020 diiron center [ion binding]; other site 676032003021 tyrosyl radical; other site 676032003022 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 676032003023 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 676032003024 ABC transporter; Region: ABC_tran_2; pfam12848 676032003025 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 676032003026 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 676032003027 DJ-1 family protein; Region: not_thiJ; TIGR01383 676032003028 conserved cys residue [active] 676032003029 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 676032003030 active site 676032003031 DNA polymerase IV; Validated; Region: PRK02406 676032003032 DNA binding site [nucleotide binding] 676032003033 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 676032003034 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 676032003035 transaldolase-like protein; Provisional; Region: PTZ00411 676032003036 active site 676032003037 dimer interface [polypeptide binding]; other site 676032003038 catalytic residue [active] 676032003039 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 676032003040 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 676032003041 interface (dimer of trimers) [polypeptide binding]; other site 676032003042 Substrate-binding/catalytic site; other site 676032003043 Zn-binding sites [ion binding]; other site 676032003044 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 676032003045 Outer membrane efflux protein; Region: OEP; pfam02321 676032003046 Outer membrane efflux protein; Region: OEP; pfam02321 676032003047 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 676032003048 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 676032003049 motif 1; other site 676032003050 active site 676032003051 motif 2; other site 676032003052 motif 3; other site 676032003053 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 676032003054 DHHA1 domain; Region: DHHA1; pfam02272 676032003055 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 676032003056 Part of AAA domain; Region: AAA_19; pfam13245 676032003057 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 676032003058 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 676032003059 epoxyqueuosine reductase; Region: TIGR00276 676032003060 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 676032003061 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 676032003062 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 676032003063 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 676032003064 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 676032003065 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 676032003066 catalytic residues [active] 676032003067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003068 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032003069 putative substrate translocation pore; other site 676032003070 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 676032003071 SelR domain; Region: SelR; cl15841 676032003072 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 676032003073 TspO/MBR family; Region: TspO_MBR; pfam03073 676032003074 BCCT family transporter; Region: BCCT; pfam02028 676032003075 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 676032003076 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 676032003077 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 676032003078 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 676032003079 active site 676032003080 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 676032003081 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 676032003082 active site 676032003083 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 676032003084 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 676032003085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 676032003086 FeS/SAM binding site; other site 676032003087 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 676032003088 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 676032003089 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 676032003090 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 676032003091 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 676032003092 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 676032003093 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 676032003094 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 676032003095 ligand binding site [chemical binding]; other site 676032003096 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 676032003097 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 676032003098 active site 676032003099 (T/H)XGH motif; other site 676032003100 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 676032003101 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 676032003102 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 676032003103 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 676032003104 catalytic residue [active] 676032003105 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 676032003106 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 676032003107 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 676032003108 Protein of unknown function DUF45; Region: DUF45; pfam01863 676032003109 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 676032003110 Prephenate dehydratase; Region: PDT; pfam00800 676032003111 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 676032003112 putative L-Phe binding site [chemical binding]; other site 676032003113 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 676032003114 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 676032003115 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 676032003116 active site 676032003117 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 676032003118 dimer interface [polypeptide binding]; other site 676032003119 substrate binding site [chemical binding]; other site 676032003120 catalytic residues [active] 676032003121 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 676032003122 putative C-terminal domain interface [polypeptide binding]; other site 676032003123 putative GSH binding site [chemical binding]; other site 676032003124 putative dimer interface [polypeptide binding]; other site 676032003125 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 676032003126 putative N-terminal domain interface [polypeptide binding]; other site 676032003127 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 676032003128 hypothetical protein; Provisional; Region: PRK14013 676032003129 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 676032003130 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 676032003131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 676032003132 motif II; other site 676032003133 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 676032003134 glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095 676032003135 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 676032003136 POT family; Region: PTR2; cl17359 676032003137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003138 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 676032003139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 676032003140 Walker A/P-loop; other site 676032003141 ATP binding site [chemical binding]; other site 676032003142 Q-loop/lid; other site 676032003143 ABC transporter signature motif; other site 676032003144 Walker B; other site 676032003145 D-loop; other site 676032003146 H-loop/switch region; other site 676032003147 TOBE domain; Region: TOBE_2; pfam08402 676032003148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 676032003149 dimer interface [polypeptide binding]; other site 676032003150 conserved gate region; other site 676032003151 putative PBP binding loops; other site 676032003152 ABC-ATPase subunit interface; other site 676032003153 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 676032003154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 676032003155 dimer interface [polypeptide binding]; other site 676032003156 conserved gate region; other site 676032003157 putative PBP binding loops; other site 676032003158 ABC-ATPase subunit interface; other site 676032003159 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 676032003160 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 676032003161 RuvA N terminal domain; Region: RuvA_N; pfam01330 676032003162 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 676032003163 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 676032003164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003165 putative substrate translocation pore; other site 676032003166 D-galactonate transporter; Region: 2A0114; TIGR00893 676032003167 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 676032003168 active site 676032003169 putative DNA-binding cleft [nucleotide binding]; other site 676032003170 dimer interface [polypeptide binding]; other site 676032003171 hypothetical protein; Validated; Region: PRK00110 676032003172 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 676032003173 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 676032003174 conserved cys residue [active] 676032003175 lipoyl synthase; Provisional; Region: PRK05481 676032003176 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 676032003177 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 676032003178 Ferritin-like domain; Region: Ferritin; pfam00210 676032003179 ferroxidase diiron center [ion binding]; other site 676032003180 POT family; Region: PTR2; cl17359 676032003181 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 676032003182 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 676032003183 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 676032003184 N-terminal domain interface [polypeptide binding]; other site 676032003185 dimer interface [polypeptide binding]; other site 676032003186 substrate binding pocket (H-site) [chemical binding]; other site 676032003187 ferredoxin; Provisional; Region: PRK08764 676032003188 Putative Fe-S cluster; Region: FeS; cl17515 676032003189 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 676032003190 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 676032003191 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 676032003192 minor groove reading motif; other site 676032003193 helix-hairpin-helix signature motif; other site 676032003194 substrate binding pocket [chemical binding]; other site 676032003195 active site 676032003196 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 676032003197 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 676032003198 YccA-like proteins; Region: YccA_like; cd10433 676032003199 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 676032003200 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 676032003201 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 676032003202 ATP binding site [chemical binding]; other site 676032003203 putative Mg++ binding site [ion binding]; other site 676032003204 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 676032003205 nucleotide binding region [chemical binding]; other site 676032003206 ATP-binding site [chemical binding]; other site 676032003207 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 676032003208 DDE superfamily endonuclease; Region: DDE_3; pfam13358 676032003209 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 676032003210 active site 676032003211 catalytic residues [active] 676032003212 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 676032003213 Flavoprotein; Region: Flavoprotein; cl19190 676032003214 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 676032003215 benzoate transport; Region: 2A0115; TIGR00895 676032003216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003217 putative substrate translocation pore; other site 676032003218 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 676032003219 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 676032003220 DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850 676032003221 Proline dehydrogenase; Region: Pro_dh; pfam01619 676032003222 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 676032003223 Glutamate binding site [chemical binding]; other site 676032003224 NAD binding site [chemical binding]; other site 676032003225 catalytic residues [active] 676032003226 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 676032003227 NAD(P) binding site [chemical binding]; other site 676032003228 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 676032003229 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 676032003230 active site 676032003231 dimer interface [polypeptide binding]; other site 676032003232 metal binding site [ion binding]; metal-binding site 676032003233 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 676032003234 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 676032003235 ADP binding site [chemical binding]; other site 676032003236 magnesium binding site [ion binding]; other site 676032003237 putative shikimate binding site; other site 676032003238 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 676032003239 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 676032003240 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 676032003241 Pilus assembly protein, PilP; Region: PilP; cl19831 676032003242 Pilus assembly protein, PilO; Region: PilO; cl01234 676032003243 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 676032003244 adenylate kinase; Reviewed; Region: adk; PRK00279 676032003245 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 676032003246 AMP-binding site [chemical binding]; other site 676032003247 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 676032003248 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 676032003249 FAD binding domain; Region: FAD_binding_4; pfam01565 676032003250 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 676032003251 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 676032003252 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 676032003253 GTPase Era; Reviewed; Region: era; PRK00089 676032003254 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 676032003255 G1 box; other site 676032003256 GTP/Mg2+ binding site [chemical binding]; other site 676032003257 Switch I region; other site 676032003258 G2 box; other site 676032003259 Switch II region; other site 676032003260 G3 box; other site 676032003261 G4 box; other site 676032003262 G5 box; other site 676032003263 KH domain; Region: KH_2; pfam07650 676032003264 aspartate aminotransferase; Provisional; Region: PRK05764 676032003265 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 676032003266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032003267 homodimer interface [polypeptide binding]; other site 676032003268 catalytic residue [active] 676032003269 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 676032003270 putative active site [active] 676032003271 putative dimer interface [polypeptide binding]; other site 676032003272 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 676032003273 Glycoprotease family; Region: Peptidase_M22; pfam00814 676032003274 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 676032003275 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 676032003276 active site 676032003277 dimer interface [polypeptide binding]; other site 676032003278 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 676032003279 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 676032003280 GTP/Mg2+ binding site [chemical binding]; other site 676032003281 G4 box; other site 676032003282 G5 box; other site 676032003283 G1 box; other site 676032003284 Switch I region; other site 676032003285 G2 box; other site 676032003286 G3 box; other site 676032003287 Switch II region; other site 676032003288 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 676032003289 Sel1-like repeats; Region: SEL1; smart00671 676032003290 Sel1-like repeats; Region: SEL1; smart00671 676032003291 TPR repeat; Region: TPR_11; pfam13414 676032003292 Sel1 repeat; Region: Sel1; pfam08238 676032003293 HsdM N-terminal domain; Region: HsdM_N; pfam12161 676032003294 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 676032003295 Methyltransferase domain; Region: Methyltransf_26; pfam13659 676032003296 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 676032003297 DNA-binding site [nucleotide binding]; DNA binding site 676032003298 RNA-binding motif; other site 676032003299 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 676032003300 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 676032003301 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 676032003302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 676032003303 ATP binding site [chemical binding]; other site 676032003304 putative Mg++ binding site [ion binding]; other site 676032003305 helicase superfamily c-terminal domain; Region: HELICc; smart00490 676032003306 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 676032003307 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 676032003308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 676032003309 ATP binding site [chemical binding]; other site 676032003310 putative Mg++ binding site [ion binding]; other site 676032003311 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 676032003312 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 676032003313 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 676032003314 G1 box; other site 676032003315 putative GEF interaction site [polypeptide binding]; other site 676032003316 GTP/Mg2+ binding site [chemical binding]; other site 676032003317 Switch I region; other site 676032003318 G2 box; other site 676032003319 G3 box; other site 676032003320 Switch II region; other site 676032003321 G4 box; other site 676032003322 G5 box; other site 676032003323 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 676032003324 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 676032003325 Methyltransferase domain; Region: Methyltransf_31; pfam13847 676032003326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032003327 S-adenosylmethionine binding site [chemical binding]; other site 676032003328 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 676032003329 VacJ like lipoprotein; Region: VacJ; cl01073 676032003330 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 676032003331 FAD dependent oxidoreductase; Region: DAO; pfam01266 676032003332 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 676032003333 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 676032003334 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 676032003335 putative coenzyme Q binding site [chemical binding]; other site 676032003336 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 676032003337 SmpB-tmRNA interface; other site 676032003338 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 676032003339 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 676032003340 Ligand Binding Site [chemical binding]; other site 676032003341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003342 metabolite-proton symporter; Region: 2A0106; TIGR00883 676032003343 putative substrate translocation pore; other site 676032003344 Domain of Unknown Function with PDB structure (DUF3864); Region: DUF3864; pfam12980 676032003345 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 676032003346 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 676032003347 generic binding surface II; other site 676032003348 generic binding surface I; other site 676032003349 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 676032003350 putative dimer interface [polypeptide binding]; other site 676032003351 putative active site [active] 676032003352 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 676032003353 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 676032003354 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 676032003355 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 676032003356 Uncharacterized conserved protein [Function unknown]; Region: COG2308 676032003357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003358 metabolite-proton symporter; Region: 2A0106; TIGR00883 676032003359 putative substrate translocation pore; other site 676032003360 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 676032003361 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 676032003362 ATP binding site [chemical binding]; other site 676032003363 substrate interface [chemical binding]; other site 676032003364 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 676032003365 dimer interface [polypeptide binding]; other site 676032003366 substrate binding site [chemical binding]; other site 676032003367 ATP binding site [chemical binding]; other site 676032003368 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 676032003369 thiamine phosphate binding site [chemical binding]; other site 676032003370 active site 676032003371 pyrophosphate binding site [ion binding]; other site 676032003372 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 676032003373 ThiS interaction site; other site 676032003374 putative active site [active] 676032003375 tetramer interface [polypeptide binding]; other site 676032003376 Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ThiS; COG2104 676032003377 charged pocket; other site 676032003378 hydrophobic patch; other site 676032003379 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 676032003380 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 676032003381 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 676032003382 ThiC-associated domain; Region: ThiC-associated; pfam13667 676032003383 ThiC family; Region: ThiC; pfam01964 676032003384 glutamate racemase; Provisional; Region: PRK00865 676032003385 Nuclease-related domain; Region: NERD; pfam08378 676032003386 excinuclease ABC subunit B; Provisional; Region: PRK05298 676032003387 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 676032003388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 676032003389 ATP-binding site [chemical binding]; other site 676032003390 ATP binding site [chemical binding]; other site 676032003391 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 676032003392 nucleotide binding region [chemical binding]; other site 676032003393 ATP-binding site [chemical binding]; other site 676032003394 Ultra-violet resistance protein B; Region: UvrB; pfam12344 676032003395 UvrB/uvrC motif; Region: UVR; pfam02151 676032003396 exonuclease I; Provisional; Region: sbcB; PRK11779 676032003397 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 676032003398 active site 676032003399 catalytic site [active] 676032003400 substrate binding site [chemical binding]; other site 676032003401 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 676032003402 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 676032003403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 676032003404 NAD(P) binding site [chemical binding]; other site 676032003405 active site 676032003406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 676032003407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 676032003408 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 676032003409 putative effector binding pocket; other site 676032003410 dimerization interface [polypeptide binding]; other site 676032003411 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 676032003412 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 676032003413 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 676032003414 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 676032003415 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 676032003416 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 676032003417 tetramer (dimer of dimers) interface [polypeptide binding]; other site 676032003418 active site 676032003419 dimer interface [polypeptide binding]; other site 676032003420 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 676032003421 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 676032003422 active site 676032003423 Zn binding site [ion binding]; other site 676032003424 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 676032003425 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 676032003426 23S rRNA binding site [nucleotide binding]; other site 676032003427 L21 binding site [polypeptide binding]; other site 676032003428 L13 binding site [polypeptide binding]; other site 676032003429 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 676032003430 translation initiation factor IF-3; Region: infC; TIGR00168 676032003431 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 676032003432 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 676032003433 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 676032003434 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 676032003435 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 676032003436 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 676032003437 active site 676032003438 dimer interface [polypeptide binding]; other site 676032003439 motif 1; other site 676032003440 motif 2; other site 676032003441 motif 3; other site 676032003442 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 676032003443 anticodon binding site; other site 676032003444 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 676032003445 Chitin binding domain; Region: Chitin_bind_3; pfam03067 676032003446 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 676032003447 aromatic chitin/cellulose binding site residues [chemical binding]; other site 676032003448 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 676032003449 lipoyl attachment site [posttranslational modification]; other site 676032003450 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 676032003451 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 676032003452 active site 676032003453 homodimer interface [polypeptide binding]; other site 676032003454 hypothetical protein; Validated; Region: PRK00153 676032003455 recombination protein RecR; Provisional; Region: PRK13844 676032003456 RecR protein; Region: RecR; pfam02132 676032003457 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 676032003458 putative active site [active] 676032003459 putative metal-binding site [ion binding]; other site 676032003460 tetramer interface [polypeptide binding]; other site 676032003461 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 676032003462 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 676032003463 Zn2+ binding site [ion binding]; other site 676032003464 Mg2+ binding site [ion binding]; other site 676032003465 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 676032003466 synthetase active site [active] 676032003467 NTP binding site [chemical binding]; other site 676032003468 metal binding site [ion binding]; metal-binding site 676032003469 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 676032003470 ACT domain; Region: ACT_4; pfam13291 676032003471 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 676032003472 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 676032003473 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 676032003474 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 676032003475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003476 metabolite-proton symporter; Region: 2A0106; TIGR00883 676032003477 putative substrate translocation pore; other site 676032003478 Asparaginase [Amino acid transport and metabolism]; Region: COG1446 676032003479 active site 676032003480 dimer interface [polypeptide binding]; other site 676032003481 catalytic nucleophile [active] 676032003482 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 676032003483 proposed catalytic triad [active] 676032003484 active site nucleophile [active] 676032003485 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 676032003486 substrate binding site [chemical binding]; other site 676032003487 ATP binding site [chemical binding]; other site 676032003488 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 676032003489 POT family; Region: PTR2; cl17359 676032003490 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 676032003491 active site 676032003492 homotetramer interface [polypeptide binding]; other site 676032003493 homodimer interface [polypeptide binding]; other site 676032003494 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 676032003495 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 676032003496 dimer interface [polypeptide binding]; other site 676032003497 active site 676032003498 Schiff base residues; other site 676032003499 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 676032003500 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 676032003501 DNA polymerase III subunit delta'; Validated; Region: PRK08485 676032003502 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 676032003503 putative inner membrane peptidase; Provisional; Region: PRK11778 676032003504 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 676032003505 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 676032003506 tandem repeat interface [polypeptide binding]; other site 676032003507 oligomer interface [polypeptide binding]; other site 676032003508 active site residues [active] 676032003509 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 676032003510 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 676032003511 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 676032003512 N-terminal domain interface [polypeptide binding]; other site 676032003513 dimer interface [polypeptide binding]; other site 676032003514 substrate binding pocket (H-site) [chemical binding]; other site 676032003515 DsrC like protein; Region: DsrC; pfam04358 676032003516 oxidative damage protection protein; Provisional; Region: PRK05408 676032003517 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 676032003518 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 676032003519 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 676032003520 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 676032003521 Ligand binding site; other site 676032003522 Putative Catalytic site; other site 676032003523 DXD motif; other site 676032003524 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 676032003525 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 676032003526 putative active site [active] 676032003527 YdjC motif; other site 676032003528 Mg binding site [ion binding]; other site 676032003529 putative homodimer interface [polypeptide binding]; other site 676032003530 cell division protein FtsW; Region: ftsW; TIGR02614 676032003531 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 676032003532 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 676032003533 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 676032003534 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 676032003535 Mg++ binding site [ion binding]; other site 676032003536 putative catalytic motif [active] 676032003537 putative substrate binding site [chemical binding]; other site 676032003538 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 676032003539 active site 676032003540 metal-binding site [ion binding] 676032003541 nucleotide-binding site [chemical binding]; other site 676032003542 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 676032003543 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 676032003544 active site 676032003545 HIGH motif; other site 676032003546 KMSKS motif; other site 676032003547 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 676032003548 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 676032003549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003550 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 676032003551 putative substrate translocation pore; other site 676032003552 ABC transporter ATPase component; Reviewed; Region: PRK11147 676032003553 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 676032003554 ABC transporter; Region: ABC_tran_2; pfam12848 676032003555 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 676032003556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003557 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032003558 putative substrate translocation pore; other site 676032003559 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 676032003560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003561 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032003562 putative substrate translocation pore; other site 676032003563 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 676032003564 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 676032003565 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 676032003566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 676032003567 motif II; other site 676032003568 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 676032003569 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 676032003570 putative glycosyl transferase; Provisional; Region: PRK10073 676032003571 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 676032003572 active site 676032003573 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 676032003574 metal-binding site 676032003575 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 676032003576 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 676032003577 NADP binding site [chemical binding]; other site 676032003578 active site 676032003579 putative substrate binding site [chemical binding]; other site 676032003580 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 676032003581 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 676032003582 NADP-binding site; other site 676032003583 homotetramer interface [polypeptide binding]; other site 676032003584 substrate binding site [chemical binding]; other site 676032003585 homodimer interface [polypeptide binding]; other site 676032003586 active site 676032003587 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 676032003588 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 676032003589 Methyltransferase domain; Region: Methyltransf_23; pfam13489 676032003590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032003591 S-adenosylmethionine binding site [chemical binding]; other site 676032003592 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 676032003593 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 676032003594 active site 676032003595 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 676032003596 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 676032003597 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 676032003598 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 676032003599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 676032003600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032003601 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 676032003602 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 676032003603 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 676032003604 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 676032003605 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 676032003606 putative ADP-binding pocket [chemical binding]; other site 676032003607 UDP-glucose 4-epimerase; Region: PLN02240 676032003608 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 676032003609 NAD binding site [chemical binding]; other site 676032003610 homodimer interface [polypeptide binding]; other site 676032003611 active site 676032003612 substrate binding site [chemical binding]; other site 676032003613 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 676032003614 CoA binding domain; Region: CoA_binding; cl17356 676032003615 Bacterial sugar transferase; Region: Bac_transf; pfam02397 676032003616 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 676032003617 substrate binding site [chemical binding]; other site 676032003618 hexamer interface [polypeptide binding]; other site 676032003619 metal binding site [ion binding]; metal-binding site 676032003620 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 676032003621 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 676032003622 putative active site [active] 676032003623 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 676032003624 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 676032003625 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 676032003626 NAD binding site [chemical binding]; other site 676032003627 homotetramer interface [polypeptide binding]; other site 676032003628 homodimer interface [polypeptide binding]; other site 676032003629 substrate binding site [chemical binding]; other site 676032003630 active site 676032003631 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 676032003632 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 676032003633 dimer interface [polypeptide binding]; other site 676032003634 active site 676032003635 metal binding site [ion binding]; metal-binding site 676032003636 glutathione binding site [chemical binding]; other site 676032003637 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 676032003638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 676032003639 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 676032003640 active site 676032003641 motif I; other site 676032003642 motif II; other site 676032003643 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 676032003644 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 676032003645 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 676032003646 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 676032003647 Squalene epoxidase; Region: SE; cl17314 676032003648 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 676032003649 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 676032003650 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 676032003651 BolA-like protein; Region: BolA; cl00386 676032003652 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 676032003653 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 676032003654 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 676032003655 Recombination protein O N terminal; Region: RecO_N; pfam11967 676032003656 Recombination protein O C terminal; Region: RecO_C; pfam02565 676032003657 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 676032003658 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 676032003659 catalytic residue [active] 676032003660 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 676032003661 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 676032003662 homodimer interface [polypeptide binding]; other site 676032003663 oligonucleotide binding site [chemical binding]; other site 676032003664 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 676032003665 YqfQ-like protein; Region: YqfQ; pfam14181 676032003666 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 676032003667 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 676032003668 dimerization interface [polypeptide binding]; other site 676032003669 active site 676032003670 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 676032003671 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 676032003672 ligand binding site [chemical binding]; other site 676032003673 NAD binding site [chemical binding]; other site 676032003674 tetramer interface [polypeptide binding]; other site 676032003675 catalytic site [active] 676032003676 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 676032003677 L-serine binding site [chemical binding]; other site 676032003678 ACT domain interface; other site 676032003679 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 676032003680 Ligand Binding Site [chemical binding]; other site 676032003681 TilS substrate C-terminal domain; Region: TilS_C; smart00977 676032003682 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 676032003683 POT family; Region: PTR2; cl17359 676032003684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003685 putative substrate translocation pore; other site 676032003686 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 676032003687 active site 676032003688 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 676032003689 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 676032003690 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 676032003691 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 676032003692 Ligand binding site; other site 676032003693 metal-binding site 676032003694 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952 676032003695 hypothetical protein; Provisional; Region: PRK05255 676032003696 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 676032003697 dimer interface [polypeptide binding]; other site 676032003698 active site 676032003699 glycine-pyridoxal phosphate binding site [chemical binding]; other site 676032003700 folate binding site [chemical binding]; other site 676032003701 FAD binding domain; Region: FAD_binding_4; pfam01565 676032003702 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 676032003703 Berberine and berberine like; Region: BBE; pfam08031 676032003704 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 676032003705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 676032003706 TPR motif; other site 676032003707 binding surface 676032003708 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 676032003709 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 676032003710 RNA binding surface [nucleotide binding]; other site 676032003711 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 676032003712 active site 676032003713 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 676032003714 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 676032003715 Permease; Region: Permease; pfam02405 676032003716 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 676032003717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 676032003718 Walker A/P-loop; other site 676032003719 ATP binding site [chemical binding]; other site 676032003720 Q-loop/lid; other site 676032003721 ABC transporter signature motif; other site 676032003722 Walker B; other site 676032003723 D-loop; other site 676032003724 H-loop/switch region; other site 676032003725 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 676032003726 mce related protein; Region: MCE; pfam02470 676032003727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 676032003728 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 676032003729 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 676032003730 POT family; Region: PTR2; cl17359 676032003731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003732 putative substrate translocation pore; other site 676032003733 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 676032003734 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 676032003735 acyl-activating enzyme (AAE) consensus motif; other site 676032003736 putative AMP binding site [chemical binding]; other site 676032003737 putative active site [active] 676032003738 putative CoA binding site [chemical binding]; other site 676032003739 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 676032003740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 676032003741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 676032003742 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 676032003743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003744 putative substrate translocation pore; other site 676032003745 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 676032003746 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 676032003747 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 676032003748 HlyD family secretion protein; Region: HlyD_3; pfam13437 676032003749 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 676032003750 Outer membrane efflux protein; Region: OEP; pfam02321 676032003751 Outer membrane efflux protein; Region: OEP; pfam02321 676032003752 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 676032003753 homodimer interface [polypeptide binding]; other site 676032003754 NAD binding pocket [chemical binding]; other site 676032003755 ATP binding pocket [chemical binding]; other site 676032003756 Mg binding site [ion binding]; other site 676032003757 active-site loop [active] 676032003758 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 676032003759 Pirin-related protein [General function prediction only]; Region: COG1741 676032003760 Pirin; Region: Pirin; pfam02678 676032003761 Transcriptional regulator [Transcription]; Region: LysR; COG0583 676032003762 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 676032003763 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 676032003764 putative effector binding pocket; other site 676032003765 dimerization interface [polypeptide binding]; other site 676032003766 chaperone protein DnaJ; Provisional; Region: PRK10767 676032003767 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 676032003768 HSP70 interaction site [polypeptide binding]; other site 676032003769 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 676032003770 substrate binding site [polypeptide binding]; other site 676032003771 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 676032003772 Zn binding sites [ion binding]; other site 676032003773 dimer interface [polypeptide binding]; other site 676032003774 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 676032003775 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 676032003776 nucleotide binding site [chemical binding]; other site 676032003777 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 676032003778 dimer interface [polypeptide binding]; other site 676032003779 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 676032003780 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 676032003781 MltA specific insert domain; Region: MltA; smart00925 676032003782 3D domain; Region: 3D; pfam06725 676032003783 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 676032003784 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 676032003785 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 676032003786 23S rRNA interface [nucleotide binding]; other site 676032003787 L3 interface [polypeptide binding]; other site 676032003788 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 676032003789 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 676032003790 Stringent starvation protein B; Region: SspB; cl01120 676032003791 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 676032003792 Na binding site [ion binding]; other site 676032003793 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 676032003794 RNA/DNA hybrid binding site [nucleotide binding]; other site 676032003795 active site 676032003796 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 676032003797 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 676032003798 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 676032003799 active site 676032003800 phosphorylation site [posttranslational modification] 676032003801 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 676032003802 30S subunit binding site; other site 676032003803 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 676032003804 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 676032003805 trmE is a tRNA modification GTPase; Region: trmE; cd04164 676032003806 G1 box; other site 676032003807 GTP/Mg2+ binding site [chemical binding]; other site 676032003808 Switch I region; other site 676032003809 G2 box; other site 676032003810 Switch II region; other site 676032003811 G3 box; other site 676032003812 G4 box; other site 676032003813 G5 box; other site 676032003814 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 676032003815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 676032003816 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 676032003817 putative DNA binding site [nucleotide binding]; other site 676032003818 putative Zn2+ binding site [ion binding]; other site 676032003819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 676032003820 dimerization interface [polypeptide binding]; other site 676032003821 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 676032003822 active site 676032003823 cysteine synthase; Region: PLN02565 676032003824 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 676032003825 dimer interface [polypeptide binding]; other site 676032003826 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032003827 catalytic residue [active] 676032003828 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 676032003829 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 676032003830 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 676032003831 Intracellular growth locus C protein; Region: IglC; pfam11550 676032003832 Protein of unknown function (DUF877); Region: DUF877; pfam05943 676032003833 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 676032003834 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 676032003835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003836 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 676032003837 putative substrate translocation pore; other site 676032003838 Trehalase; Region: Trehalase; cl17346 676032003839 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 676032003840 intersubunit interface [polypeptide binding]; other site 676032003841 active site 676032003842 zinc binding site [ion binding]; other site 676032003843 Na+ binding site [ion binding]; other site 676032003844 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 676032003845 pyruvate kinase; Provisional; Region: PRK05826 676032003846 domain interfaces; other site 676032003847 active site 676032003848 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 676032003849 substrate binding site [chemical binding]; other site 676032003850 hinge regions; other site 676032003851 ADP binding site [chemical binding]; other site 676032003852 catalytic site [active] 676032003853 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 676032003854 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 676032003855 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 676032003856 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 676032003857 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 676032003858 TPP-binding site [chemical binding]; other site 676032003859 dimer interface [polypeptide binding]; other site 676032003860 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 676032003861 PYR/PP interface [polypeptide binding]; other site 676032003862 dimer interface [polypeptide binding]; other site 676032003863 TPP binding site [chemical binding]; other site 676032003864 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 676032003865 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 676032003866 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 676032003867 putative phosphate acyltransferase; Provisional; Region: PRK05331 676032003868 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 676032003869 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 676032003870 dimer interface [polypeptide binding]; other site 676032003871 active site 676032003872 CoA binding pocket [chemical binding]; other site 676032003873 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 676032003874 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 676032003875 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 676032003876 NAD(P) binding site [chemical binding]; other site 676032003877 homotetramer interface [polypeptide binding]; other site 676032003878 homodimer interface [polypeptide binding]; other site 676032003879 active site 676032003880 acyl carrier protein; Provisional; Region: acpP; PRK00982 676032003881 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 676032003882 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 676032003883 dimer interface [polypeptide binding]; other site 676032003884 active site 676032003885 YCII-related domain; Region: YCII; cl00999 676032003886 Uncharacterized conserved protein [Function unknown]; Region: COG4121 676032003887 putative transporter; Provisional; Region: PRK03699 676032003888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032003889 putative substrate translocation pore; other site 676032003890 Predicted membrane protein [Function unknown]; Region: COG2855 676032003891 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 676032003892 active site 676032003893 dimerization interface [polypeptide binding]; other site 676032003894 16S rRNA methyltransferase B; Provisional; Region: PRK10901 676032003895 NusB family; Region: NusB; pfam01029 676032003896 putative RNA binding site [nucleotide binding]; other site 676032003897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032003898 S-adenosylmethionine binding site [chemical binding]; other site 676032003899 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 676032003900 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 676032003901 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 676032003902 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 676032003903 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 676032003904 nucleotide binding pocket [chemical binding]; other site 676032003905 K-X-D-G motif; other site 676032003906 catalytic site [active] 676032003907 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 676032003908 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 676032003909 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 676032003910 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 676032003911 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 676032003912 Dimer interface [polypeptide binding]; other site 676032003913 BRCT sequence motif; other site 676032003914 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 676032003915 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 676032003916 active site 676032003917 oligomerization interface [polypeptide binding]; other site 676032003918 metal binding site [ion binding]; metal-binding site 676032003919 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 676032003920 active site 676032003921 nucleotide binding site [chemical binding]; other site 676032003922 HIGH motif; other site 676032003923 KMSKS motif; other site 676032003924 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 676032003925 tetramerization interface [polypeptide binding]; other site 676032003926 active site 676032003927 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 676032003928 nucleotide binding site [chemical binding]; other site 676032003929 Type III pantothenate kinase; Region: Pan_kinase; cl17198 676032003930 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 676032003931 AAA domain; Region: AAA_30; pfam13604 676032003932 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 676032003933 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 676032003934 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 676032003935 ATP binding site [chemical binding]; other site 676032003936 putative Mg++ binding site [ion binding]; other site 676032003937 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 676032003938 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 676032003939 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 676032003940 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 676032003941 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 676032003942 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 676032003943 active site 676032003944 FMN binding site [chemical binding]; other site 676032003945 substrate binding site [chemical binding]; other site 676032003946 3Fe-4S cluster binding site [ion binding]; other site 676032003947 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 676032003948 EamA-like transporter family; Region: EamA; pfam00892 676032003949 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 676032003950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 676032003951 non-specific DNA binding site [nucleotide binding]; other site 676032003952 salt bridge; other site 676032003953 sequence-specific DNA binding site [nucleotide binding]; other site 676032003954 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 676032003955 Catalytic site [active] 676032003956 FeoA domain; Region: FeoA; cl00838 676032003957 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 676032003958 Sporulation related domain; Region: SPOR; pfam05036 676032003959 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 676032003960 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 676032003961 intersubunit interface [polypeptide binding]; other site 676032003962 HemX; Region: HemX; cl19375 676032003963 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 676032003964 active site 676032003965 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 676032003966 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 676032003967 prolyl-tRNA synthetase; Provisional; Region: PRK09194 676032003968 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 676032003969 dimer interface [polypeptide binding]; other site 676032003970 motif 1; other site 676032003971 active site 676032003972 motif 2; other site 676032003973 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 676032003974 putative deacylase active site [active] 676032003975 motif 3; other site 676032003976 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 676032003977 anticodon binding site; other site 676032003978 methionine aminotransferase; Validated; Region: PRK09082 676032003979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 676032003980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032003981 homodimer interface [polypeptide binding]; other site 676032003982 catalytic residue [active] 676032003983 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 676032003984 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 676032003985 active site 676032003986 catalytic triad [active] 676032003987 dimer interface [polypeptide binding]; other site 676032003988 transcription antitermination factor NusB; Region: nusB; TIGR01951 676032003989 putative RNA binding site [nucleotide binding]; other site 676032003990 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; cl00497 676032003991 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 676032003992 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 676032003993 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 676032003994 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 676032003995 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 676032003996 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 676032003997 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 676032003998 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 676032003999 active site residue [active] 676032004000 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 676032004001 active site residue [active] 676032004002 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 676032004003 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 676032004004 putative DNA binding site [nucleotide binding]; other site 676032004005 putative Zn2+ binding site [ion binding]; other site 676032004006 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 676032004007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 676032004008 Coenzyme A binding pocket [chemical binding]; other site 676032004009 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 676032004010 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 676032004011 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 676032004012 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 676032004013 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 676032004014 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 676032004015 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 676032004016 ATP-NAD kinase; Region: NAD_kinase; cl01255 676032004017 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 676032004018 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 676032004019 Ligand binding site; other site 676032004020 Putative Catalytic site; other site 676032004021 DXD motif; other site 676032004022 ABC-2 type transporter; Region: ABC2_membrane; cl17235 676032004023 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 676032004024 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 676032004025 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 676032004026 Walker A/P-loop; other site 676032004027 ATP binding site [chemical binding]; other site 676032004028 Q-loop/lid; other site 676032004029 ABC transporter signature motif; other site 676032004030 Walker B; other site 676032004031 D-loop; other site 676032004032 H-loop/switch region; other site 676032004033 hypothetical protein; Provisional; Region: PRK10621 676032004034 Cupin domain; Region: Cupin_2; cl17218 676032004035 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 676032004036 active site 676032004037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032004038 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032004039 putative substrate translocation pore; other site 676032004040 Ferritin-like domain; Region: Ferritin; pfam00210 676032004041 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 676032004042 dinuclear metal binding motif [ion binding]; other site 676032004043 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 676032004044 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 676032004045 dimer interface [polypeptide binding]; other site 676032004046 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 676032004047 recombination factor protein RarA; Reviewed; Region: PRK13342 676032004048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 676032004049 Walker A motif; other site 676032004050 ATP binding site [chemical binding]; other site 676032004051 Walker B motif; other site 676032004052 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl19688 676032004053 arginine finger; other site 676032004054 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 676032004055 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 676032004056 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 676032004057 catalytic residues [active] 676032004058 transcription termination factor Rho; Provisional; Region: rho; PRK09376 676032004059 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 676032004060 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 676032004061 RNA binding site [nucleotide binding]; other site 676032004062 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 676032004063 multimer interface [polypeptide binding]; other site 676032004064 Walker A motif; other site 676032004065 ATP binding site [chemical binding]; other site 676032004066 Walker B motif; other site 676032004067 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 676032004068 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 676032004069 active site 676032004070 substrate binding site [chemical binding]; other site 676032004071 metal binding site [ion binding]; metal-binding site 676032004072 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 676032004073 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 676032004074 Substrate binding site; other site 676032004075 Cupin domain; Region: Cupin_2; cl17218 676032004076 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 676032004077 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 676032004078 NAD binding site [chemical binding]; other site 676032004079 substrate binding site [chemical binding]; other site 676032004080 homodimer interface [polypeptide binding]; other site 676032004081 active site 676032004082 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 676032004083 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 676032004084 substrate binding site; other site 676032004085 tetramer interface; other site 676032004086 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 676032004087 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 676032004088 inhibitor-cofactor binding pocket; inhibition site 676032004089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032004090 catalytic residue [active] 676032004091 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 676032004092 active site 676032004093 substrate binding site [chemical binding]; other site 676032004094 cosubstrate binding site; other site 676032004095 catalytic site [active] 676032004096 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 676032004097 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 676032004098 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 676032004099 WxcM-like, C-terminal; Region: FdtA; pfam05523 676032004100 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 676032004101 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 676032004102 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 676032004103 active site 676032004104 dimer interface [polypeptide binding]; other site 676032004105 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 676032004106 Ligand Binding Site [chemical binding]; other site 676032004107 Molecular Tunnel; other site 676032004108 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 676032004109 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 676032004110 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 676032004111 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 676032004112 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 676032004113 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 676032004114 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; cl09440 676032004115 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 676032004116 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 676032004117 active site 676032004118 homodimer interface [polypeptide binding]; other site 676032004119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 676032004120 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 676032004121 NAD(P) binding site [chemical binding]; other site 676032004122 active site 676032004123 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 676032004124 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 676032004125 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 676032004126 NAD(P) binding site [chemical binding]; other site 676032004127 homodimer interface [polypeptide binding]; other site 676032004128 substrate binding site [chemical binding]; other site 676032004129 active site 676032004130 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 676032004131 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 676032004132 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 676032004133 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 676032004134 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 676032004135 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 676032004136 catalytic residue [active] 676032004137 Bacterial sugar transferase; Region: Bac_transf; pfam02397 676032004138 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 676032004139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 676032004140 Coenzyme A binding pocket [chemical binding]; other site 676032004141 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 676032004142 inhibitor-cofactor binding pocket; inhibition site 676032004143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032004144 catalytic residue [active] 676032004145 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 676032004146 CoA binding domain; Region: CoA_binding; cl17356 676032004147 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 676032004148 NAD(P) binding site [chemical binding]; other site 676032004149 homodimer interface [polypeptide binding]; other site 676032004150 substrate binding site [chemical binding]; other site 676032004151 active site 676032004152 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 676032004153 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 676032004154 ATP binding site [chemical binding]; other site 676032004155 putative Mg++ binding site [ion binding]; other site 676032004156 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 676032004157 nucleotide binding region [chemical binding]; other site 676032004158 ATP-binding site [chemical binding]; other site 676032004159 Helicase associated domain (HA2); Region: HA2; pfam04408 676032004160 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 676032004161 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 676032004162 Chain length determinant protein; Region: Wzz; pfam02706 676032004163 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 676032004164 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 676032004165 catalytic residues [active] 676032004166 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 676032004167 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 676032004168 acyl-activating enzyme (AAE) consensus motif; other site 676032004169 putative AMP binding site [chemical binding]; other site 676032004170 putative active site [active] 676032004171 putative CoA binding site [chemical binding]; other site 676032004172 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 676032004173 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 676032004174 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 676032004175 active site 676032004176 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 676032004177 Acyl CoA binding protein; Region: ACBP; pfam00887 676032004178 acyl-CoA binding pocket [chemical binding]; other site 676032004179 CoA binding site [chemical binding]; other site 676032004180 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 676032004181 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 676032004182 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 676032004183 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 676032004184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 676032004185 substrate binding site [chemical binding]; other site 676032004186 oxyanion hole (OAH) forming residues; other site 676032004187 trimer interface [polypeptide binding]; other site 676032004188 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 676032004189 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 676032004190 dimer interface [polypeptide binding]; other site 676032004191 active site 676032004192 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 676032004193 CoenzymeA binding site [chemical binding]; other site 676032004194 subunit interaction site [polypeptide binding]; other site 676032004195 PHB binding site; other site 676032004196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032004197 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 676032004198 putative substrate translocation pore; other site 676032004199 Protein of unknown function (DUF465); Region: DUF465; cl01070 676032004200 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 676032004201 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 676032004202 active site 676032004203 ornithine cyclodeaminase; Validated; Region: PRK07589 676032004204 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 676032004205 Amidinotransferase; Region: Amidinotransf; pfam02274 676032004206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 676032004207 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 676032004208 Methyltransferase domain; Region: Methyltransf_31; pfam13847 676032004209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032004210 S-adenosylmethionine binding site [chemical binding]; other site 676032004211 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 676032004212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 676032004213 active site 676032004214 phosphorylation site [posttranslational modification] 676032004215 intermolecular recognition site; other site 676032004216 dimerization interface [polypeptide binding]; other site 676032004217 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 676032004218 DNA binding site [nucleotide binding] 676032004219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 676032004220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 676032004221 dimer interface [polypeptide binding]; other site 676032004222 phosphorylation site [posttranslational modification] 676032004223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 676032004224 ATP binding site [chemical binding]; other site 676032004225 Mg2+ binding site [ion binding]; other site 676032004226 G-X-G motif; other site 676032004227 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 676032004228 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 676032004229 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 676032004230 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 676032004231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032004232 S-adenosylmethionine binding site [chemical binding]; other site 676032004233 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 676032004234 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 676032004235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 676032004236 NAD(P) binding site [chemical binding]; other site 676032004237 active site 676032004238 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 676032004239 Di-iron ligands [ion binding]; other site 676032004240 ribonuclease R; Region: RNase_R; TIGR02063 676032004241 RNB domain; Region: RNB; pfam00773 676032004242 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 676032004243 RNA binding site [nucleotide binding]; other site 676032004244 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 676032004245 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 676032004246 RNA binding site [nucleotide binding]; other site 676032004247 active site 676032004248 ribonuclease III; Reviewed; Region: rnc; PRK00102 676032004249 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 676032004250 dimerization interface [polypeptide binding]; other site 676032004251 active site 676032004252 metal binding site [ion binding]; metal-binding site 676032004253 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 676032004254 dsRNA binding site [nucleotide binding]; other site 676032004255 signal peptidase I; Provisional; Region: PRK10861 676032004256 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 676032004257 Catalytic site [active] 676032004258 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 676032004259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 676032004260 active site 676032004261 phosphorylation site [posttranslational modification] 676032004262 intermolecular recognition site; other site 676032004263 dimerization interface [polypeptide binding]; other site 676032004264 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 676032004265 DNA binding site [nucleotide binding] 676032004266 PrpF protein; Region: PrpF; cl19418 676032004267 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 676032004268 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 676032004269 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 676032004270 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 676032004271 active site 676032004272 dimerization interface [polypeptide binding]; other site 676032004273 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 676032004274 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 676032004275 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 676032004276 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 676032004277 substrate binding pocket [chemical binding]; other site 676032004278 chain length determination region; other site 676032004279 substrate-Mg2+ binding site; other site 676032004280 catalytic residues [active] 676032004281 aspartate-rich region 1; other site 676032004282 active site lid residues [active] 676032004283 aspartate-rich region 2; other site 676032004284 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 676032004285 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 676032004286 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 676032004287 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 676032004288 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 676032004289 active site 676032004290 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 676032004291 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 676032004292 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 676032004293 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 676032004294 active site 676032004295 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 676032004296 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 676032004297 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 676032004298 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 676032004299 trimer interface [polypeptide binding]; other site 676032004300 active site 676032004301 UDP-GlcNAc binding site [chemical binding]; other site 676032004302 lipid binding site [chemical binding]; lipid-binding site 676032004303 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 676032004304 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 676032004305 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 676032004306 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 676032004307 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 676032004308 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 676032004309 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 676032004310 Surface antigen; Region: Bac_surface_Ag; pfam01103 676032004311 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 676032004312 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 676032004313 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 676032004314 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 676032004315 DNA gyrase subunit A; Validated; Region: PRK05560 676032004316 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 676032004317 CAP-like domain; other site 676032004318 active site 676032004319 primary dimer interface [polypeptide binding]; other site 676032004320 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 676032004321 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 676032004322 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 676032004323 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 676032004324 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 676032004325 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 676032004326 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 676032004327 aromatic chitin/cellulose binding site residues [chemical binding]; other site 676032004328 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 676032004329 ligand binding site [chemical binding]; other site 676032004330 active site 676032004331 UGI interface [polypeptide binding]; other site 676032004332 catalytic site [active] 676032004333 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 676032004334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 676032004335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 676032004336 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 676032004337 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 676032004338 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 676032004339 E3 interaction surface; other site 676032004340 lipoyl attachment site [posttranslational modification]; other site 676032004341 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 676032004342 E3 interaction surface; other site 676032004343 lipoyl attachment site [posttranslational modification]; other site 676032004344 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 676032004345 E3 interaction surface; other site 676032004346 lipoyl attachment site [posttranslational modification]; other site 676032004347 e3 binding domain; Region: E3_binding; pfam02817 676032004348 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 676032004349 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 676032004350 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 676032004351 dimer interface [polypeptide binding]; other site 676032004352 TPP-binding site [chemical binding]; other site 676032004353 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 676032004354 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102 676032004355 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 676032004356 CoA-binding site [chemical binding]; other site 676032004357 ATP-binding [chemical binding]; other site 676032004358 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 676032004359 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 676032004360 active site 676032004361 HIGH motif; other site 676032004362 dimer interface [polypeptide binding]; other site 676032004363 KMSKS motif; other site 676032004364 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 676032004365 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 676032004366 putative active site pocket [active] 676032004367 putative catalytic residue [active] 676032004368 potential frameshift: common BLAST hit: gi|169656727|ref|YP_001429206.2| LD-carboxypeptidase family protein 676032004369 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 676032004370 potential frameshift: common BLAST hit: gi|169656727|ref|YP_001429206.2| LD-carboxypeptidase family protein 676032004371 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 676032004372 dimer interface [polypeptide binding]; other site 676032004373 catalytic triad [active] 676032004374 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 676032004375 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 676032004376 putative active site [active] 676032004377 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 676032004378 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 676032004379 MutS domain I; Region: MutS_I; pfam01624 676032004380 MutS domain III; Region: MutS_III; pfam05192 676032004381 MutS domain V; Region: MutS_V; pfam00488 676032004382 Walker A/P-loop; other site 676032004383 ATP binding site [chemical binding]; other site 676032004384 Q-loop/lid; other site 676032004385 ABC transporter signature motif; other site 676032004386 Walker B; other site 676032004387 D-loop; other site 676032004388 H-loop/switch region; other site 676032004389 preprotein translocase subunit SecB; Validated; Region: PRK05751 676032004390 SecA binding site; other site 676032004391 Preprotein binding site; other site 676032004392 hypothetical protein; Provisional; Region: PRK07206 676032004393 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 676032004394 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 676032004395 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 676032004396 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 676032004397 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 676032004398 active site 676032004399 DNA binding site [nucleotide binding] 676032004400 Int/Topo IB signature motif; other site 676032004401 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 676032004402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032004403 S-adenosylmethionine binding site [chemical binding]; other site 676032004404 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 676032004405 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 676032004406 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 676032004407 HD domain; Region: HD_4; pfam13328 676032004408 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 676032004409 synthetase active site [active] 676032004410 NTP binding site [chemical binding]; other site 676032004411 metal binding site [ion binding]; metal-binding site 676032004412 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 676032004413 Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; Region: PI3Ka; cl00271 676032004414 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 676032004415 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 676032004416 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 676032004417 EamA-like transporter family; Region: EamA; pfam00892 676032004418 EamA-like transporter family; Region: EamA; pfam00892 676032004419 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 676032004420 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 676032004421 HSP70 interaction site [polypeptide binding]; other site 676032004422 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 676032004423 substrate binding site [polypeptide binding]; other site 676032004424 dimer interface [polypeptide binding]; other site 676032004425 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 676032004426 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 676032004427 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 676032004428 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 676032004429 mercuric reductase; Validated; Region: PRK06370 676032004430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 676032004431 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 676032004432 Uncharacterized conserved protein [Function unknown]; Region: COG0398 676032004433 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 676032004434 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 676032004435 DNA binding site [nucleotide binding] 676032004436 active site 676032004437 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 676032004438 FAM70 protein; Region: FAM70; pfam14967 676032004439 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 676032004440 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 676032004441 active site 676032004442 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 676032004443 substrate binding site [chemical binding]; other site 676032004444 catalytic residues [active] 676032004445 dimer interface [polypeptide binding]; other site 676032004446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 676032004447 glutamate dehydrogenase; Provisional; Region: PRK09414 676032004448 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 676032004449 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 676032004450 NAD(P) binding site [chemical binding]; other site 676032004451 HI0933-like protein; Region: HI0933_like; pfam03486 676032004452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 676032004453 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 676032004454 short chain dehydrogenase; Validated; Region: PRK06182 676032004455 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 676032004456 NADP binding site [chemical binding]; other site 676032004457 active site 676032004458 steroid binding site; other site 676032004459 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 676032004460 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 676032004461 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 676032004462 ring oligomerisation interface [polypeptide binding]; other site 676032004463 ATP/Mg binding site [chemical binding]; other site 676032004464 stacking interactions; other site 676032004465 hinge regions; other site 676032004466 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 676032004467 oligomerisation interface [polypeptide binding]; other site 676032004468 mobile loop; other site 676032004469 roof hairpin; other site 676032004470 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 676032004471 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 676032004472 hypothetical protein; Validated; Region: PRK02101 676032004473 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 676032004474 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 676032004475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032004476 S-adenosylmethionine binding site [chemical binding]; other site 676032004477 peptide chain release factor 1; Validated; Region: prfA; PRK00591 676032004478 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 676032004479 This domain is found in peptide chain release factors; Region: PCRF; smart00937 676032004480 RF-1 domain; Region: RF-1; pfam00472 676032004481 glutamyl-tRNA reductase; Provisional; Region: PRK13940 676032004482 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 676032004483 tRNA; other site 676032004484 putative tRNA binding site [nucleotide binding]; other site 676032004485 putative NADP binding site [chemical binding]; other site 676032004486 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 676032004487 Tetratricopeptide repeat; Region: TPR_21; pfam09976 676032004488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 676032004489 TPR motif; other site 676032004490 binding surface 676032004491 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 676032004492 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 676032004493 Trp docking motif [polypeptide binding]; other site 676032004494 active site 676032004495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032004496 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 676032004497 putative substrate translocation pore; other site 676032004498 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 676032004499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 676032004500 ATP binding site [chemical binding]; other site 676032004501 Mg2+ binding site [ion binding]; other site 676032004502 G-X-G motif; other site 676032004503 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 676032004504 anchoring element; other site 676032004505 dimer interface [polypeptide binding]; other site 676032004506 ATP binding site [chemical binding]; other site 676032004507 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 676032004508 active site 676032004509 metal binding site [ion binding]; metal-binding site 676032004510 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 676032004511 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 676032004512 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 676032004513 amidase catalytic site [active] 676032004514 Zn binding residues [ion binding]; other site 676032004515 substrate binding site [chemical binding]; other site 676032004516 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 676032004517 active site 676032004518 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 676032004519 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 676032004520 putative active site [active] 676032004521 Ap4A binding site [chemical binding]; other site 676032004522 nudix motif; other site 676032004523 putative metal binding site [ion binding]; other site 676032004524 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 676032004525 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 676032004526 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 676032004527 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Region: PLN03002 676032004528 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 676032004529 organizer of macrodomain of Terminus of chromosome; Region: MatP; cl11476 676032004530 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 676032004531 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 676032004532 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 676032004533 active site 676032004534 Int/Topo IB signature motif; other site 676032004535 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 676032004536 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 676032004537 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 676032004538 RimM N-terminal domain; Region: RimM; pfam01782 676032004539 PRC-barrel domain; Region: PRC; pfam05239 676032004540 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 676032004541 S-adenosylmethionine synthetase; Validated; Region: PRK05250 676032004542 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 676032004543 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 676032004544 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 676032004545 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 676032004546 Di-iron ligands [ion binding]; other site 676032004547 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 676032004548 UGMP family protein; Validated; Region: PRK09604 676032004549 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 676032004550 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 676032004551 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 676032004552 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 676032004553 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 676032004554 beta and beta' interface [polypeptide binding]; other site 676032004555 beta' and sigma factor interface [polypeptide binding]; other site 676032004556 Zn-binding [ion binding]; other site 676032004557 active site region [active] 676032004558 catalytic site [active] 676032004559 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 676032004560 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 676032004561 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 676032004562 cleft; other site 676032004563 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 676032004564 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 676032004565 G-loop; other site 676032004566 DNA binding site [nucleotide binding] 676032004567 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 676032004568 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 676032004569 RPB12 interaction site [polypeptide binding]; other site 676032004570 RPB1 interaction site [polypeptide binding]; other site 676032004571 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 676032004572 RPB10 interaction site [polypeptide binding]; other site 676032004573 RPB11 interaction site [polypeptide binding]; other site 676032004574 RPB3 interaction site [polypeptide binding]; other site 676032004575 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 676032004576 core dimer interface [polypeptide binding]; other site 676032004577 peripheral dimer interface [polypeptide binding]; other site 676032004578 L10 interface [polypeptide binding]; other site 676032004579 L11 interface [polypeptide binding]; other site 676032004580 putative EF-Tu interaction site [polypeptide binding]; other site 676032004581 putative EF-G interaction site [polypeptide binding]; other site 676032004582 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 676032004583 23S rRNA interface [nucleotide binding]; other site 676032004584 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 676032004585 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 676032004586 mRNA/rRNA interface [nucleotide binding]; other site 676032004587 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 676032004588 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 676032004589 23S rRNA interface [nucleotide binding]; other site 676032004590 L7/L12 interface [polypeptide binding]; other site 676032004591 putative thiostrepton binding site; other site 676032004592 L25 interface [polypeptide binding]; other site 676032004593 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 676032004594 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 676032004595 putative homodimer interface [polypeptide binding]; other site 676032004596 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 676032004597 heterodimer interface [polypeptide binding]; other site 676032004598 homodimer interface [polypeptide binding]; other site 676032004599 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 676032004600 elongation factor Tu; Reviewed; Region: PRK00049 676032004601 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 676032004602 G1 box; other site 676032004603 GEF interaction site [polypeptide binding]; other site 676032004604 GTP/Mg2+ binding site [chemical binding]; other site 676032004605 Switch I region; other site 676032004606 G2 box; other site 676032004607 G3 box; other site 676032004608 Switch II region; other site 676032004609 G4 box; other site 676032004610 G5 box; other site 676032004611 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 676032004612 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 676032004613 Antibiotic Binding Site [chemical binding]; other site 676032004614 AAA domain; Region: AAA_30; pfam13604 676032004615 AAA domain; Region: AAA_11; pfam13086 676032004616 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 676032004617 Mechanosensitive ion channel; Region: MS_channel; pfam00924 676032004618 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 676032004619 amphipathic channel; other site 676032004620 Asn-Pro-Ala signature motifs; other site 676032004621 Uncharacterized conserved protein [Function unknown]; Region: COG3586 676032004622 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 676032004623 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 676032004624 glycerol kinase; Provisional; Region: glpK; PRK00047 676032004625 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 676032004626 N- and C-terminal domain interface [polypeptide binding]; other site 676032004627 active site 676032004628 MgATP binding site [chemical binding]; other site 676032004629 catalytic site [active] 676032004630 metal binding site [ion binding]; metal-binding site 676032004631 glycerol binding site [chemical binding]; other site 676032004632 homotetramer interface [polypeptide binding]; other site 676032004633 homodimer interface [polypeptide binding]; other site 676032004634 FBP binding site [chemical binding]; other site 676032004635 protein IIAGlc interface [polypeptide binding]; other site 676032004636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032004637 putative substrate translocation pore; other site 676032004638 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032004639 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 676032004640 Sel1 repeat; Region: Sel1; pfam08238 676032004641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032004642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032004643 putative substrate translocation pore; other site 676032004644 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 676032004645 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 676032004646 Walker A/P-loop; other site 676032004647 ATP binding site [chemical binding]; other site 676032004648 Q-loop/lid; other site 676032004649 ABC transporter signature motif; other site 676032004650 Walker B; other site 676032004651 D-loop; other site 676032004652 H-loop/switch region; other site 676032004653 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 676032004654 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 676032004655 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 676032004656 Walker A/P-loop; other site 676032004657 ATP binding site [chemical binding]; other site 676032004658 Q-loop/lid; other site 676032004659 ABC transporter signature motif; other site 676032004660 Walker B; other site 676032004661 D-loop; other site 676032004662 H-loop/switch region; other site 676032004663 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 676032004664 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 676032004665 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 676032004666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 676032004667 dimer interface [polypeptide binding]; other site 676032004668 conserved gate region; other site 676032004669 putative PBP binding loops; other site 676032004670 ABC-ATPase subunit interface; other site 676032004671 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 676032004672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 676032004673 dimer interface [polypeptide binding]; other site 676032004674 conserved gate region; other site 676032004675 putative PBP binding loops; other site 676032004676 ABC-ATPase subunit interface; other site 676032004677 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 676032004678 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 676032004679 peptide binding site [polypeptide binding]; other site 676032004680 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 676032004681 Part of AAA domain; Region: AAA_19; pfam13245 676032004682 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 676032004683 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 676032004684 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 676032004685 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 676032004686 P loop; other site 676032004687 GTP binding site [chemical binding]; other site 676032004688 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 676032004689 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 676032004690 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 676032004691 G1 box; other site 676032004692 putative GEF interaction site [polypeptide binding]; other site 676032004693 GTP/Mg2+ binding site [chemical binding]; other site 676032004694 Switch I region; other site 676032004695 G2 box; other site 676032004696 G3 box; other site 676032004697 Switch II region; other site 676032004698 G4 box; other site 676032004699 G5 box; other site 676032004700 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 676032004701 thymidylate kinase; Validated; Region: tmk; PRK00698 676032004702 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 676032004703 TMP-binding site; other site 676032004704 ATP-binding site [chemical binding]; other site 676032004705 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 676032004706 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 676032004707 Nucleoside recognition; Region: Gate; pfam07670 676032004708 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 676032004709 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 676032004710 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 676032004711 Nucleoside recognition; Region: Gate; pfam07670 676032004712 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 676032004713 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 676032004714 intersubunit interface [polypeptide binding]; other site 676032004715 active site 676032004716 catalytic residue [active] 676032004717 phosphopentomutase; Provisional; Region: PRK05362 676032004718 pantothenate kinase; Reviewed; Region: PRK13324 676032004719 DNA polymerase I; Provisional; Region: PRK05755 676032004720 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 676032004721 active site 676032004722 metal binding site 1 [ion binding]; metal-binding site 676032004723 putative 5' ssDNA interaction site; other site 676032004724 metal binding site 3; metal-binding site 676032004725 metal binding site 2 [ion binding]; metal-binding site 676032004726 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 676032004727 putative DNA binding site [nucleotide binding]; other site 676032004728 putative metal binding site [ion binding]; other site 676032004729 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 676032004730 active site 676032004731 catalytic site [active] 676032004732 substrate binding site [chemical binding]; other site 676032004733 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 676032004734 active site 676032004735 DNA binding site [nucleotide binding] 676032004736 catalytic site [active] 676032004737 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 676032004738 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 676032004739 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 676032004740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 676032004741 Walker A/P-loop; other site 676032004742 ATP binding site [chemical binding]; other site 676032004743 Q-loop/lid; other site 676032004744 ABC transporter signature motif; other site 676032004745 Walker B; other site 676032004746 D-loop; other site 676032004747 H-loop/switch region; other site 676032004748 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 676032004749 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 676032004750 active site 676032004751 NTP binding site [chemical binding]; other site 676032004752 metal binding triad [ion binding]; metal-binding site 676032004753 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 676032004754 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 676032004755 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 676032004756 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 676032004757 HlyD family secretion protein; Region: HlyD_3; pfam13437 676032004758 multidrug efflux protein; Reviewed; Region: PRK09579 676032004759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032004760 putative substrate translocation pore; other site 676032004761 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 676032004762 ATP-grasp domain; Region: ATP-grasp_4; cl17255 676032004763 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 676032004764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 676032004765 dimer interface [polypeptide binding]; other site 676032004766 phosphorylation site [posttranslational modification] 676032004767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 676032004768 ATP binding site [chemical binding]; other site 676032004769 Mg2+ binding site [ion binding]; other site 676032004770 G-X-G motif; other site 676032004771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 676032004772 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 676032004773 NAD(P) binding site [chemical binding]; other site 676032004774 active site 676032004775 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 676032004776 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 676032004777 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 676032004778 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 676032004779 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 676032004780 Walker A motif; other site 676032004781 ATP binding site [chemical binding]; other site 676032004782 Walker B motif; other site 676032004783 aconitate hydratase; Validated; Region: PRK09277 676032004784 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 676032004785 substrate binding site [chemical binding]; other site 676032004786 ligand binding site [chemical binding]; other site 676032004787 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 676032004788 substrate binding site [chemical binding]; other site 676032004789 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 676032004790 HemN family oxidoreductase; Provisional; Region: PRK05660 676032004791 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 676032004792 FeS/SAM binding site; other site 676032004793 HemN C-terminal domain; Region: HemN_C; pfam06969 676032004794 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 676032004795 Transcriptional regulator [Transcription]; Region: LysR; COG0583 676032004796 protein translocase, SecG subunit; Region: secG; TIGR00810 676032004797 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 676032004798 dimer interface [polypeptide binding]; other site 676032004799 substrate binding site [chemical binding]; other site 676032004800 catalytic triad [active] 676032004801 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 676032004802 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 676032004803 active site 676032004804 substrate binding site [chemical binding]; other site 676032004805 metal binding site [ion binding]; metal-binding site 676032004806 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 676032004807 nucleotide binding site [chemical binding]; other site 676032004808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 676032004809 active site 676032004810 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 676032004811 E3 interaction surface; other site 676032004812 lipoyl attachment site [posttranslational modification]; other site 676032004813 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 676032004814 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 676032004815 E3 interaction surface; other site 676032004816 lipoyl attachment site [posttranslational modification]; other site 676032004817 e3 binding domain; Region: E3_binding; pfam02817 676032004818 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 676032004819 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 676032004820 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 676032004821 TPP-binding site [chemical binding]; other site 676032004822 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 676032004823 dimer interface [polypeptide binding]; other site 676032004824 PYR/PP interface [polypeptide binding]; other site 676032004825 TPP binding site [chemical binding]; other site 676032004826 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 676032004827 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 676032004828 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 676032004829 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 676032004830 L-aspartate oxidase; Provisional; Region: PRK06175 676032004831 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 676032004832 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 676032004833 SdhC subunit interface [polypeptide binding]; other site 676032004834 proximal heme binding site [chemical binding]; other site 676032004835 cardiolipin binding site; other site 676032004836 Iron-sulfur protein interface; other site 676032004837 proximal quinone binding site [chemical binding]; other site 676032004838 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 676032004839 Iron-sulfur protein interface; other site 676032004840 proximal quinone binding site [chemical binding]; other site 676032004841 SdhD (CybS) interface [polypeptide binding]; other site 676032004842 proximal heme binding site [chemical binding]; other site 676032004843 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 676032004844 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 676032004845 dimer interface [polypeptide binding]; other site 676032004846 active site 676032004847 citrylCoA binding site [chemical binding]; other site 676032004848 NADH binding [chemical binding]; other site 676032004849 cationic pore residues; other site 676032004850 oxalacetate/citrate binding site [chemical binding]; other site 676032004851 coenzyme A binding site [chemical binding]; other site 676032004852 catalytic triad [active] 676032004853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032004854 putative substrate translocation pore; other site 676032004855 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032004856 superoxide dismutase; Provisional; Region: PRK10543 676032004857 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 676032004858 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 676032004859 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 676032004860 putative GSH binding site [chemical binding]; other site 676032004861 catalytic residues [active] 676032004862 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 676032004863 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 676032004864 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 676032004865 active site 676032004866 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 676032004867 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 676032004868 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 676032004869 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 676032004870 ATP-grasp domain; Region: ATP-grasp_4; cl17255 676032004871 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318 676032004872 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 676032004873 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 676032004874 gamma subunit interface [polypeptide binding]; other site 676032004875 epsilon subunit interface [polypeptide binding]; other site 676032004876 LBP interface [polypeptide binding]; other site 676032004877 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 676032004878 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 676032004879 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 676032004880 alpha subunit interaction interface [polypeptide binding]; other site 676032004881 Walker A motif; other site 676032004882 ATP binding site [chemical binding]; other site 676032004883 Walker B motif; other site 676032004884 inhibitor binding site; inhibition site 676032004885 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 676032004886 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 676032004887 core domain interface [polypeptide binding]; other site 676032004888 delta subunit interface [polypeptide binding]; other site 676032004889 epsilon subunit interface [polypeptide binding]; other site 676032004890 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 676032004891 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 676032004892 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 676032004893 beta subunit interaction interface [polypeptide binding]; other site 676032004894 Walker A motif; other site 676032004895 ATP binding site [chemical binding]; other site 676032004896 Walker B motif; other site 676032004897 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 676032004898 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 676032004899 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 676032004900 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 676032004901 F0F1 ATP synthase subunit C; Provisional; Region: PRK13464 676032004902 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 676032004903 ATP synthase I chain; Region: ATP_synt_I; cl09170 676032004904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032004905 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032004906 putative substrate translocation pore; other site 676032004907 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 676032004908 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 676032004909 RNA binding surface [nucleotide binding]; other site 676032004910 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 676032004911 active site 676032004912 Predicted ATPase [General function prediction only]; Region: COG1485 676032004913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032004914 putative substrate translocation pore; other site 676032004915 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 676032004916 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 676032004917 dimer interface [polypeptide binding]; other site 676032004918 motif 1; other site 676032004919 active site 676032004920 motif 2; other site 676032004921 motif 3; other site 676032004922 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 676032004923 anticodon binding site; other site 676032004924 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 676032004925 translation initiation factor IF-2; Validated; Region: infB; PRK05306 676032004926 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 676032004927 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 676032004928 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 676032004929 G1 box; other site 676032004930 putative GEF interaction site [polypeptide binding]; other site 676032004931 GTP/Mg2+ binding site [chemical binding]; other site 676032004932 Switch I region; other site 676032004933 G2 box; other site 676032004934 G3 box; other site 676032004935 Switch II region; other site 676032004936 G4 box; other site 676032004937 G5 box; other site 676032004938 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 676032004939 Translation-initiation factor 2; Region: IF-2; pfam11987 676032004940 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 676032004941 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 676032004942 NusA N-terminal domain; Region: NusA_N; pfam08529 676032004943 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 676032004944 RNA binding site [nucleotide binding]; other site 676032004945 homodimer interface [polypeptide binding]; other site 676032004946 NusA-like KH domain; Region: KH_5; pfam13184 676032004947 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 676032004948 G-X-X-G motif; other site 676032004949 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 676032004950 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 676032004951 hypothetical protein; Provisional; Region: PRK14641 676032004952 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 676032004953 putative oligomer interface [polypeptide binding]; other site 676032004954 putative RNA binding site [nucleotide binding]; other site 676032004955 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 676032004956 substrate binding site [chemical binding]; other site 676032004957 active site 676032004958 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 676032004959 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 676032004960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 676032004961 Walker A motif; other site 676032004962 ATP binding site [chemical binding]; other site 676032004963 Walker B motif; other site 676032004964 arginine finger; other site 676032004965 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 676032004966 Membrane fusogenic activity; Region: BMFP; cl01115 676032004967 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 676032004968 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 676032004969 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 676032004970 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 676032004971 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 676032004972 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 676032004973 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 676032004974 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 676032004975 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 676032004976 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 676032004977 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 676032004978 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 676032004979 NADH dehydrogenase subunit G; Validated; Region: PRK09129 676032004980 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 676032004981 catalytic loop [active] 676032004982 iron binding site [ion binding]; other site 676032004983 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 676032004984 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 676032004985 molybdopterin cofactor binding site; other site 676032004986 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 676032004987 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 676032004988 SLBB domain; Region: SLBB; pfam10531 676032004989 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 676032004990 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 676032004991 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 676032004992 putative dimer interface [polypeptide binding]; other site 676032004993 [2Fe-2S] cluster binding site [ion binding]; other site 676032004994 NADH dehydrogenase subunit D; Validated; Region: PRK06075 676032004995 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 676032004996 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 676032004997 NADH dehydrogenase subunit B; Validated; Region: PRK06411 676032004998 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 676032004999 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 676032005000 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 676032005001 metal binding site 2 [ion binding]; metal-binding site 676032005002 putative DNA binding helix; other site 676032005003 metal binding site 1 [ion binding]; metal-binding site 676032005004 dimer interface [polypeptide binding]; other site 676032005005 structural Zn2+ binding site [ion binding]; other site 676032005006 IucA / IucC family; Region: IucA_IucC; pfam04183 676032005007 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 676032005008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032005009 Major Facilitator Superfamily; Region: MFS_1; pfam07690 676032005010 putative substrate translocation pore; other site 676032005011 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 676032005012 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 676032005013 dimer interface [polypeptide binding]; other site 676032005014 active site 676032005015 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 676032005016 catalytic residues [active] 676032005017 substrate binding site [chemical binding]; other site 676032005018 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 676032005019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032005020 putative substrate translocation pore; other site 676032005021 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 676032005022 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 676032005023 active site 676032005024 catalytic triad [active] 676032005025 oxyanion hole [active] 676032005026 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 676032005027 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 676032005028 GatB domain; Region: GatB_Yqey; smart00845 676032005029 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 676032005030 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 676032005031 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 676032005032 HlyD family secretion protein; Region: HlyD_3; pfam13437 676032005033 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 676032005034 adenylosuccinate lyase; Provisional; Region: PRK07492 676032005035 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 676032005036 tetramer interface [polypeptide binding]; other site 676032005037 active site 676032005038 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 676032005039 active site 676032005040 catalytic residues [active] 676032005041 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 676032005042 putative active site [active] 676032005043 potential frameshift: common BLAST hit: gi|118498260|ref|YP_899310.1| phosphoribosylformylglycinamidine synthase 676032005044 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 676032005045 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 676032005046 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 676032005047 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 676032005048 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 676032005049 dimerization interface [polypeptide binding]; other site 676032005050 ATP binding site [chemical binding]; other site 676032005051 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 676032005052 dimerization interface [polypeptide binding]; other site 676032005053 ATP binding site [chemical binding]; other site 676032005054 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 676032005055 putative active site [active] 676032005056 catalytic triad [active] 676032005057 amidophosphoribosyltransferase; Provisional; Region: PRK09246 676032005058 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 676032005059 active site 676032005060 tetramer interface [polypeptide binding]; other site 676032005061 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 676032005062 active site 676032005063 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 676032005064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032005065 catalytic residue [active] 676032005066 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 676032005067 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 676032005068 Outer membrane efflux protein; Region: OEP; pfam02321 676032005069 Outer membrane efflux protein; Region: OEP; pfam02321 676032005070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 676032005071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032005072 S-adenosylmethionine binding site [chemical binding]; other site 676032005073 putative protease; Provisional; Region: PRK15452 676032005074 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 676032005075 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 676032005076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032005077 putative substrate translocation pore; other site 676032005078 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 676032005079 Citrate transporter; Region: CitMHS; pfam03600 676032005080 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 676032005081 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 676032005082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 676032005083 Walker A/P-loop; other site 676032005084 ATP binding site [chemical binding]; other site 676032005085 Q-loop/lid; other site 676032005086 ABC transporter signature motif; other site 676032005087 Walker B; other site 676032005088 D-loop; other site 676032005089 H-loop/switch region; other site 676032005090 Amino acid permease; Region: AA_permease_2; pfam13520 676032005091 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 676032005092 GTP1/OBG; Region: GTP1_OBG; pfam01018 676032005093 Obg GTPase; Region: Obg; cd01898 676032005094 G1 box; other site 676032005095 GTP/Mg2+ binding site [chemical binding]; other site 676032005096 Switch I region; other site 676032005097 G2 box; other site 676032005098 G3 box; other site 676032005099 Switch II region; other site 676032005100 G4 box; other site 676032005101 G5 box; other site 676032005102 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 676032005103 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 676032005104 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 676032005105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 676032005106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 676032005107 active site 676032005108 phosphorylation site [posttranslational modification] 676032005109 intermolecular recognition site; other site 676032005110 dimerization interface [polypeptide binding]; other site 676032005111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 676032005112 DNA binding site [nucleotide binding] 676032005113 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 676032005114 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 676032005115 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 676032005116 Ligand Binding Site [chemical binding]; other site 676032005117 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 676032005118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 676032005119 dimer interface [polypeptide binding]; other site 676032005120 phosphorylation site [posttranslational modification] 676032005121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 676032005122 ATP binding site [chemical binding]; other site 676032005123 Mg2+ binding site [ion binding]; other site 676032005124 G-X-G motif; other site 676032005125 K+-transporting ATPase, c chain; Region: KdpC; cl00944 676032005126 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 676032005127 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 676032005128 Soluble P-type ATPase [General function prediction only]; Region: COG4087 676032005129 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 676032005130 Bacterial PH domain; Region: bPH_2; pfam03703 676032005131 aspartate aminotransferase; Provisional; Region: PRK05764 676032005132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 676032005133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032005134 homodimer interface [polypeptide binding]; other site 676032005135 catalytic residue [active] 676032005136 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 676032005137 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810 676032005138 dimer interface [polypeptide binding]; other site 676032005139 active site 676032005140 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 676032005141 catalytic residues [active] 676032005142 substrate binding site [chemical binding]; other site 676032005143 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 676032005144 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 676032005145 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 676032005146 trimer interface [polypeptide binding]; other site 676032005147 active site 676032005148 substrate binding site [chemical binding]; other site 676032005149 CoA binding site [chemical binding]; other site 676032005150 dihydrodipicolinate synthase; Provisional; Region: PRK03170 676032005151 catalytic residue [active] 676032005152 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 676032005153 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 676032005154 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 676032005155 aspartate kinase III; Validated; Region: PRK09084 676032005156 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 676032005157 nucleotide binding site [chemical binding]; other site 676032005158 substrate binding site [chemical binding]; other site 676032005159 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 676032005160 lysine allosteric regulatory site; other site 676032005161 dimer interface [polypeptide binding]; other site 676032005162 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 676032005163 Putative lysophospholipase; Region: Hydrolase_4; cl19140 676032005164 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 676032005165 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 676032005166 active site 676032005167 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 676032005168 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 676032005169 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 676032005170 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 676032005171 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 676032005172 Cl- selectivity filter; other site 676032005173 Cl- binding residues [ion binding]; other site 676032005174 pore gating glutamate residue; other site 676032005175 dimer interface [polypeptide binding]; other site 676032005176 H+/Cl- coupling transport residue; other site 676032005177 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 676032005178 active site 676032005179 Zn binding site [ion binding]; other site 676032005180 aspartoacylase; Provisional; Region: PRK02259 676032005181 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 676032005182 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 676032005183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 676032005184 catalytic residue [active] 676032005185 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 676032005186 substrate binding site [chemical binding]; other site 676032005187 active site 676032005188 catalytic residues [active] 676032005189 heterodimer interface [polypeptide binding]; other site 676032005190 Uncharacterized conserved protein [Function unknown]; Region: COG5276 676032005191 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 676032005192 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 676032005193 Clp amino terminal domain; Region: Clp_N; pfam02861 676032005194 Clp amino terminal domain; Region: Clp_N; pfam02861 676032005195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 676032005196 Walker A motif; other site 676032005197 ATP binding site [chemical binding]; other site 676032005198 Walker B motif; other site 676032005199 arginine finger; other site 676032005200 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 676032005201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 676032005202 Walker A motif; other site 676032005203 ATP binding site [chemical binding]; other site 676032005204 Walker B motif; other site 676032005205 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 676032005206 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 676032005207 aromatic chitin/cellulose binding site residues [chemical binding]; other site 676032005208 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 676032005209 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 676032005210 active site 676032005211 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 676032005212 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 676032005213 ATP-grasp domain; Region: ATP-grasp; pfam02222 676032005214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 676032005215 Frag1/DRAM/Sfk1 family; Region: Frag1; pfam10277 676032005216 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 676032005217 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 676032005218 4Fe-4S binding domain; Region: Fer4; pfam00037 676032005219 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 676032005220 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 676032005221 putative acyl-acceptor binding pocket; other site 676032005222 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 676032005223 putative acyl-acceptor binding pocket; other site 676032005224 hypothetical protein; Provisional; Region: PRK05421 676032005225 putative catalytic site [active] 676032005226 putative metal binding site [ion binding]; other site 676032005227 putative phosphate binding site [ion binding]; other site 676032005228 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854 676032005229 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 676032005230 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 676032005231 [2Fe-2S] cluster binding site [ion binding]; other site 676032005232 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 676032005233 hydrophobic ligand binding site; other site 676032005234 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 676032005235 metabolite-proton symporter; Region: 2A0106; TIGR00883 676032005236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032005237 putative substrate translocation pore; other site 676032005238 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 676032005239 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 676032005240 catalytic triad [active] 676032005241 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 676032005242 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 676032005243 putative ligand binding site [chemical binding]; other site 676032005244 putative NAD binding site [chemical binding]; other site 676032005245 catalytic site [active] 676032005246 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 676032005247 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 676032005248 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 676032005249 putative NAD(P) binding site [chemical binding]; other site 676032005250 substrate binding site [chemical binding]; other site 676032005251 Methyltransferase domain; Region: Methyltransf_31; pfam13847 676032005252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 676032005253 S-adenosylmethionine binding site [chemical binding]; other site 676032005254 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 676032005255 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 676032005256 ABC transporter; Region: ABC_tran_2; pfam12848 676032005257 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 676032005258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 676032005259 metabolite-proton symporter; Region: 2A0106; TIGR00883 676032005260 putative substrate translocation pore; other site 676032005261 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 676032005262 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 676032005263 Ureide permease; Region: Ureide_permease; pfam07168 676032005264 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 676032005265 substrate binding site [chemical binding]; other site 676032005266 dimer interface [polypeptide binding]; other site 676032005267 ATP binding site [chemical binding]; other site 676032005268 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 676032005269 aminopeptidase N; Provisional; Region: pepN; PRK14015 676032005270 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 676032005271 active site 676032005272 Zn binding site [ion binding]; other site 676032005273 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 676032005274 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 676032005275 putative dimer interface [polypeptide binding]; other site 676032005276 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 676032005277 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 676032005278 active site 676032005279 ribulose/triose binding site [chemical binding]; other site 676032005280 phosphate binding site [ion binding]; other site 676032005281 substrate (anthranilate) binding pocket [chemical binding]; other site 676032005282 product (indole) binding pocket [chemical binding]; other site 676032005283 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 676032005284 active site 676032005285 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 676032005286 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 676032005287 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 676032005288 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 676032005289 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 676032005290 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 676032005291 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 676032005292 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 676032005293 Glutamine amidotransferase class-I; Region: GATase; pfam00117 676032005294 glutamine binding [chemical binding]; other site 676032005295 catalytic triad [active] 676032005296 anthranilate synthase component I; Provisional; Region: PRK13564 676032005297 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 676032005298 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 676032005299 Trp repressor protein; Region: Trp_repressor; cl17266 676032005300 ribonuclease G; Provisional; Region: PRK11712 676032005301 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 676032005302 homodimer interface [polypeptide binding]; other site 676032005303 oligonucleotide binding site [chemical binding]; other site 676032005304 Ribonuclease E/G family; Region: RNase_E_G; pfam10150