-- dump date 20140619_094514 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1356861000001 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1356861000002 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1356861000003 active site 1356861000004 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1356861000005 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1356861000006 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1356861000007 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1356861000008 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1356861000009 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1356861000010 Cl- selectivity filter; other site 1356861000011 Cl- binding residues [ion binding]; other site 1356861000012 pore gating glutamate residue; other site 1356861000013 dimer interface [polypeptide binding]; other site 1356861000014 H+/Cl- coupling transport residue; other site 1356861000015 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1356861000016 Zn binding site [ion binding]; other site 1356861000017 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1356861000018 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1356861000019 heterodimer interface [polypeptide binding]; other site 1356861000020 substrate binding site [chemical binding]; other site 1356861000021 active site 1356861000022 catalytic residues [active] 1356861000023 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1356861000024 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1356861000025 Clp amino terminal domain; Region: Clp_N; pfam02861 1356861000026 Clp amino terminal domain; Region: Clp_N; pfam02861 1356861000027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1356861000028 Walker A motif; other site 1356861000029 ATP binding site [chemical binding]; other site 1356861000030 Walker B motif; other site 1356861000031 arginine finger; other site 1356861000032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1356861000033 Walker A motif; other site 1356861000034 ATP binding site [chemical binding]; other site 1356861000035 Walker B motif; other site 1356861000036 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1356861000037 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1356861000038 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1356861000039 ATP-grasp domain; Region: ATP-grasp; pfam02222 1356861000040 Frag1/DRAM/Sfk1 family; Region: Frag1; pfam10277 1356861000041 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1356861000042 4Fe-4S binding domain; Region: Fer4; cl02805 1356861000043 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1356861000044 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1356861000045 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1356861000046 putative acyl-acceptor binding pocket; other site 1356861000047 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1356861000048 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1356861000049 putative acyl-acceptor binding pocket; other site 1356861000050 hypothetical protein; Provisional; Region: PRK05421 1356861000051 putative catalytic site [active] 1356861000052 putative metal binding site [ion binding]; other site 1356861000053 putative phosphate binding site [ion binding]; other site 1356861000054 putative catalytic site [active] 1356861000055 putative phosphate binding site [ion binding]; other site 1356861000056 putative metal binding site [ion binding]; other site 1356861000057 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854 1356861000058 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1356861000059 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1356861000060 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1356861000061 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1356861000062 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1356861000063 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1356861000064 catalytic triad [active] 1356861000065 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1356861000066 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1356861000067 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1356861000068 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1356861000069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1356861000070 Walker A/P-loop; other site 1356861000071 ATP binding site [chemical binding]; other site 1356861000072 Q-loop/lid; other site 1356861000073 ABC transporter signature motif; other site 1356861000074 Walker B; other site 1356861000075 D-loop; other site 1356861000076 H-loop/switch region; other site 1356861000077 ABC transporter; Region: ABC_tran_2; pfam12848 1356861000078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1356861000079 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1356861000080 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1356861000081 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1356861000082 Ureide permease; Region: Ureide_permease; pfam07168 1356861000083 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1356861000084 active site 1356861000085 ribulose/triose binding site [chemical binding]; other site 1356861000086 substrate (anthranilate) binding pocket [chemical binding]; other site 1356861000087 product (indole) binding pocket [chemical binding]; other site 1356861000088 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1356861000089 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 1356861000090 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1356861000091 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1356861000092 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1356861000093 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1356861000094 glutamine binding [chemical binding]; other site 1356861000095 catalytic triad [active] 1356861000096 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1356861000097 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1356861000098 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1356861000099 anthranilate synthase component I; Provisional; Region: PRK13564 1356861000100 ribonuclease G; Provisional; Region: PRK11712 1356861000101 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1356861000102 homodimer interface [polypeptide binding]; other site 1356861000103 oligonucleotide binding site [chemical binding]; other site 1356861000104 DNA polymerase III subunit beta; Validated; Region: PRK05643 1356861000105 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1356861000106 putative DNA binding surface [nucleotide binding]; other site 1356861000107 dimer interface [polypeptide binding]; other site 1356861000108 beta-clamp/clamp loader binding surface; other site 1356861000109 beta-clamp/translesion DNA polymerase binding surface; other site 1356861000110 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1356861000111 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1356861000112 Cl binding site [ion binding]; other site 1356861000113 oligomer interface [polypeptide binding]; other site 1356861000114 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1356861000115 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1356861000116 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1356861000117 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1356861000118 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1356861000119 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1356861000120 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1356861000121 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1356861000122 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1356861000123 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1356861000124 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1356861000125 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1356861000126 substrate binding site [chemical binding]; other site 1356861000127 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1356861000128 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1356861000129 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1356861000130 catalytic site [active] 1356861000131 subunit interface [polypeptide binding]; other site 1356861000132 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1356861000133 catalytic core [active] 1356861000134 dihydroorotase; Reviewed; Region: PRK09236 1356861000135 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1356861000136 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1356861000137 active site 1356861000138 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1356861000139 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1356861000140 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 1356861000141 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1356861000142 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1356861000143 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1356861000144 HlyD family secretion protein; Region: HlyD_3; pfam13437 1356861000145 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1356861000146 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1356861000147 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1356861000148 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1356861000149 dimerization interface [polypeptide binding]; other site 1356861000150 Chorismate mutase type II; Region: CM_2; cl00693 1356861000151 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1356861000152 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1356861000153 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1356861000154 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1356861000155 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1356861000156 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1356861000157 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1356861000158 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1356861000159 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1356861000160 active site 1356861000161 dimer interface [polypeptide binding]; other site 1356861000162 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1356861000163 phosphate binding site [ion binding]; other site 1356861000164 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1356861000165 putative active site [active] 1356861000166 dimerization interface [polypeptide binding]; other site 1356861000167 putative tRNAtyr binding site [nucleotide binding]; other site 1356861000168 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1356861000169 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1356861000170 homodimer interface [polypeptide binding]; other site 1356861000171 substrate-cofactor binding pocket; other site 1356861000172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861000173 catalytic residue [active] 1356861000174 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1356861000175 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1356861000176 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1356861000177 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1356861000178 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1356861000179 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1356861000180 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1356861000181 catalytic site [active] 1356861000182 putative active site [active] 1356861000183 putative substrate binding site [chemical binding]; other site 1356861000184 dimer interface [polypeptide binding]; other site 1356861000185 elongation factor P; Validated; Region: PRK00529 1356861000186 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1356861000187 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1356861000188 RNA binding site [nucleotide binding]; other site 1356861000189 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1356861000190 RNA binding site [nucleotide binding]; other site 1356861000191 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1356861000192 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1356861000193 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1356861000194 putative acyl-acceptor binding pocket; other site 1356861000195 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1356861000196 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1356861000197 putative acyl-acceptor binding pocket; other site 1356861000198 membrane protein insertase; Provisional; Region: PRK01318 1356861000199 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1356861000200 Haemolytic domain; Region: Haemolytic; cl00506 1356861000201 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1356861000202 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1356861000203 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1356861000204 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1356861000205 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1356861000206 shikimate binding site; other site 1356861000207 NAD(P) binding site [chemical binding]; other site 1356861000208 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1356861000209 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1356861000210 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1356861000211 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1356861000212 Predicted methyltransferases [General function prediction only]; Region: COG0313 1356861000213 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1356861000214 putative SAM binding site [chemical binding]; other site 1356861000215 putative homodimer interface [polypeptide binding]; other site 1356861000216 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1356861000217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1356861000218 active site 1356861000219 motif I; other site 1356861000220 motif II; other site 1356861000221 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1356861000222 PLD-like domain; Region: PLDc_2; pfam13091 1356861000223 putative homodimer interface [polypeptide binding]; other site 1356861000224 putative active site [active] 1356861000225 catalytic site [active] 1356861000226 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1356861000227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1356861000228 ATP binding site [chemical binding]; other site 1356861000229 putative Mg++ binding site [ion binding]; other site 1356861000230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1356861000231 nucleotide binding region [chemical binding]; other site 1356861000232 ATP-binding site [chemical binding]; other site 1356861000233 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1356861000234 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1356861000235 Ligand Binding Site [chemical binding]; other site 1356861000236 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1356861000237 Ligand Binding Site [chemical binding]; other site 1356861000238 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1356861000239 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1356861000240 LamB/YcsF family protein; Provisional; Region: PRK05406 1356861000241 Sulfatase; Region: Sulfatase; cl17466 1356861000242 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1356861000243 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1356861000244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1356861000245 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1356861000246 putative FMN binding site [chemical binding]; other site 1356861000247 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1356861000248 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1356861000249 aromatic amino acid transport protein; Region: araaP; TIGR00837 1356861000250 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1356861000251 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1356861000252 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1356861000253 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1356861000254 catalytic residue [active] 1356861000255 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1356861000256 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1356861000257 putative effector binding pocket; other site 1356861000258 dimerization interface [polypeptide binding]; other site 1356861000259 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1356861000260 dimer interface [polypeptide binding]; other site 1356861000261 active site 1356861000262 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1356861000263 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 1356861000264 trimer interface [polypeptide binding]; other site 1356861000265 putative substrate binding pocket [chemical binding]; other site 1356861000266 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1356861000267 GTP-binding protein LepA; Provisional; Region: PRK05433 1356861000268 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1356861000269 G1 box; other site 1356861000270 putative GEF interaction site [polypeptide binding]; other site 1356861000271 GTP/Mg2+ binding site [chemical binding]; other site 1356861000272 Switch I region; other site 1356861000273 G2 box; other site 1356861000274 G3 box; other site 1356861000275 Switch II region; other site 1356861000276 G4 box; other site 1356861000277 G5 box; other site 1356861000278 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1356861000279 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1356861000280 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1356861000281 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1356861000282 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1356861000283 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1356861000284 active site 1356861000285 catalytic residues [active] 1356861000286 metal binding site [ion binding]; metal-binding site 1356861000287 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1356861000288 homopentamer interface [polypeptide binding]; other site 1356861000289 active site 1356861000290 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1356861000291 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1356861000292 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1356861000293 dimerization interface [polypeptide binding]; other site 1356861000294 active site 1356861000295 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1356861000296 Lumazine binding domain; Region: Lum_binding; pfam00677 1356861000297 Lumazine binding domain; Region: Lum_binding; pfam00677 1356861000298 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1356861000299 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1356861000300 catalytic motif [active] 1356861000301 Zn binding site [ion binding]; other site 1356861000302 RibD C-terminal domain; Region: RibD_C; pfam01872 1356861000303 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1356861000304 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1356861000305 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1356861000306 tandem repeat interface [polypeptide binding]; other site 1356861000307 oligomer interface [polypeptide binding]; other site 1356861000308 active site residues [active] 1356861000309 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1356861000310 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1356861000311 preprotein translocase subunit SecB; Provisional; Region: PRK13031 1356861000312 SecA binding site; other site 1356861000313 Preprotein binding site; other site 1356861000314 recombinase A; Provisional; Region: recA; PRK09354 1356861000315 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1356861000316 hexamer interface [polypeptide binding]; other site 1356861000317 Walker A motif; other site 1356861000318 ATP binding site [chemical binding]; other site 1356861000319 Walker B motif; other site 1356861000320 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1356861000321 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1356861000322 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1356861000323 dimer interface [polypeptide binding]; other site 1356861000324 ssDNA binding site [nucleotide binding]; other site 1356861000325 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1356861000326 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1356861000327 propionate/acetate kinase; Provisional; Region: PRK12379 1356861000328 phosphate acetyltransferase; Reviewed; Region: PRK05632 1356861000329 DRTGG domain; Region: DRTGG; pfam07085 1356861000330 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1356861000331 succinic semialdehyde dehydrogenase; Region: PLN02278 1356861000332 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1356861000333 tetramerization interface [polypeptide binding]; other site 1356861000334 NAD(P) binding site [chemical binding]; other site 1356861000335 catalytic residues [active] 1356861000336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1356861000337 Coenzyme A binding pocket [chemical binding]; other site 1356861000338 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1356861000339 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1356861000340 putative active site [active] 1356861000341 catalytic triad [active] 1356861000342 putative dimer interface [polypeptide binding]; other site 1356861000343 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1356861000344 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1356861000345 dimer interface [polypeptide binding]; other site 1356861000346 anticodon binding site; other site 1356861000347 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1356861000348 homodimer interface [polypeptide binding]; other site 1356861000349 motif 1; other site 1356861000350 active site 1356861000351 motif 2; other site 1356861000352 GAD domain; Region: GAD; pfam02938 1356861000353 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1356861000354 active site 1356861000355 motif 3; other site 1356861000356 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 1356861000357 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1356861000358 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1356861000359 RNB domain; Region: RNB; pfam00773 1356861000360 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1356861000361 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1356861000362 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1356861000363 domain interfaces; other site 1356861000364 active site 1356861000365 camphor resistance protein CrcB; Provisional; Region: PRK14226 1356861000366 Zinc-finger domain; Region: zf-CHCC; cl01821 1356861000367 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1356861000368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1356861000369 dimer interface [polypeptide binding]; other site 1356861000370 conserved gate region; other site 1356861000371 putative PBP binding loops; other site 1356861000372 ABC-ATPase subunit interface; other site 1356861000373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1356861000374 dimer interface [polypeptide binding]; other site 1356861000375 conserved gate region; other site 1356861000376 putative PBP binding loops; other site 1356861000377 ABC-ATPase subunit interface; other site 1356861000378 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1356861000379 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1356861000380 Walker A/P-loop; other site 1356861000381 ATP binding site [chemical binding]; other site 1356861000382 Q-loop/lid; other site 1356861000383 ABC transporter signature motif; other site 1356861000384 Walker B; other site 1356861000385 D-loop; other site 1356861000386 H-loop/switch region; other site 1356861000387 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1356861000388 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1356861000389 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1356861000390 TrkA-N domain; Region: TrkA_N; pfam02254 1356861000391 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1356861000392 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1356861000393 trimer interface [polypeptide binding]; other site 1356861000394 putative metal binding site [ion binding]; other site 1356861000395 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1356861000396 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1356861000397 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1356861000398 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1356861000399 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 1356861000400 putative active site [active] 1356861000401 Zn binding site [ion binding]; other site 1356861000402 YGGT family; Region: YGGT; pfam02325 1356861000403 YGGT family; Region: YGGT; pfam02325 1356861000404 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1356861000405 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1356861000406 Walker A/P-loop; other site 1356861000407 ATP binding site [chemical binding]; other site 1356861000408 Q-loop/lid; other site 1356861000409 ABC transporter signature motif; other site 1356861000410 Walker B; other site 1356861000411 D-loop; other site 1356861000412 H-loop/switch region; other site 1356861000413 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 1356861000414 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1356861000415 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1356861000416 Competence protein; Region: Competence; cl00471 1356861000417 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1356861000418 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1356861000419 putative acyl-acceptor binding pocket; other site 1356861000420 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1356861000421 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1356861000422 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1356861000423 RNA binding site [nucleotide binding]; other site 1356861000424 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1356861000425 RNA binding site [nucleotide binding]; other site 1356861000426 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1356861000427 RNA binding site [nucleotide binding]; other site 1356861000428 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1356861000429 RNA binding site [nucleotide binding]; other site 1356861000430 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1356861000431 RNA binding site [nucleotide binding]; other site 1356861000432 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1356861000433 RNA binding site [nucleotide binding]; other site 1356861000434 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1356861000435 nucleoside/Zn binding site; other site 1356861000436 dimer interface [polypeptide binding]; other site 1356861000437 catalytic motif [active] 1356861000438 D-alanyl-alanine synthetase A; Provisional; Region: PRK14569 1356861000439 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1356861000440 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1356861000441 Cell division protein FtsQ; Region: FtsQ; pfam03799 1356861000442 cell division protein FtsA; Region: ftsA; TIGR01174 1356861000443 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1356861000444 nucleotide binding site [chemical binding]; other site 1356861000445 Cell division protein FtsA; Region: FtsA; pfam14450 1356861000446 cell division protein FtsZ; Validated; Region: PRK09330 1356861000447 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1356861000448 nucleotide binding site [chemical binding]; other site 1356861000449 SulA interaction site; other site 1356861000450 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1356861000451 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1356861000452 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1356861000453 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1356861000454 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 1356861000455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1356861000456 Walker A motif; other site 1356861000457 ATP binding site [chemical binding]; other site 1356861000458 Walker B motif; other site 1356861000459 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1356861000460 arginine finger; other site 1356861000461 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1356861000462 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1356861000463 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1356861000464 RF-1 domain; Region: RF-1; pfam00472 1356861000465 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1356861000466 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1356861000467 dimer interface [polypeptide binding]; other site 1356861000468 putative anticodon binding site; other site 1356861000469 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1356861000470 motif 1; other site 1356861000471 active site 1356861000472 motif 2; other site 1356861000473 motif 3; other site 1356861000474 hypothetical protein; Provisional; Region: PRK05208 1356861000475 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1356861000476 Glutaminase; Region: Glutaminase; cl00907 1356861000477 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1356861000478 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1356861000479 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1356861000480 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1356861000481 glutamine synthetase; Region: PLN02284 1356861000482 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1356861000483 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1356861000484 DNA polymerase III, delta subunit; Region: holA; TIGR01128 1356861000485 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1356861000486 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1356861000487 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1356861000488 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1356861000489 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1356861000490 purine monophosphate binding site [chemical binding]; other site 1356861000491 dimer interface [polypeptide binding]; other site 1356861000492 putative catalytic residues [active] 1356861000493 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1356861000494 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1356861000495 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1356861000496 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1356861000497 GDP-binding site [chemical binding]; other site 1356861000498 ACT binding site; other site 1356861000499 IMP binding site; other site 1356861000500 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1356861000501 active site 1356861000502 Dienelactone hydrolase family; Region: DLH; pfam01738 1356861000503 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1356861000504 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1356861000505 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1356861000506 ABC-ATPase subunit interface; other site 1356861000507 dimer interface [polypeptide binding]; other site 1356861000508 putative PBP binding regions; other site 1356861000509 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1356861000510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1356861000511 Walker A/P-loop; other site 1356861000512 ATP binding site [chemical binding]; other site 1356861000513 Q-loop/lid; other site 1356861000514 ABC transporter signature motif; other site 1356861000515 Walker B; other site 1356861000516 D-loop; other site 1356861000517 H-loop/switch region; other site 1356861000518 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1356861000519 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1356861000520 intersubunit interface [polypeptide binding]; other site 1356861000521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861000522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1356861000523 putative substrate translocation pore; other site 1356861000524 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1356861000525 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1356861000526 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1356861000527 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1356861000528 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1356861000529 primosome assembly protein PriA; Validated; Region: PRK05580 1356861000530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1356861000531 ATP binding site [chemical binding]; other site 1356861000532 putative Mg++ binding site [ion binding]; other site 1356861000533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1356861000534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1356861000535 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1356861000536 substrate binding pocket [chemical binding]; other site 1356861000537 membrane-bound complex binding site; other site 1356861000538 hinge residues; other site 1356861000539 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1356861000540 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1356861000541 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1356861000542 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1356861000543 TIGR01210 family protein; Region: TIGR01210 1356861000544 pyridoxamine kinase; Validated; Region: PRK05756 1356861000545 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1356861000546 dimer interface [polypeptide binding]; other site 1356861000547 pyridoxal binding site [chemical binding]; other site 1356861000548 ATP binding site [chemical binding]; other site 1356861000549 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1356861000550 MoxR-like ATPases [General function prediction only]; Region: COG0714 1356861000551 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 1356861000552 Walker A motif; other site 1356861000553 ATP binding site [chemical binding]; other site 1356861000554 Walker B motif; other site 1356861000555 arginine finger; other site 1356861000556 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1356861000557 Protein of unknown function DUF58; Region: DUF58; pfam01882 1356861000558 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1356861000559 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1356861000560 metal ion-dependent adhesion site (MIDAS); other site 1356861000561 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1356861000562 metal ion-dependent adhesion site (MIDAS); other site 1356861000563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1356861000564 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1356861000565 TPR motif; other site 1356861000566 binding surface 1356861000567 Oxygen tolerance; Region: BatD; pfam13584 1356861000568 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 1356861000569 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1356861000570 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1356861000571 HIGH motif; other site 1356861000572 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1356861000573 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1356861000574 active site 1356861000575 KMSKS motif; other site 1356861000576 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1356861000577 tRNA binding surface [nucleotide binding]; other site 1356861000578 anticodon binding site; other site 1356861000579 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1356861000580 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1356861000581 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1356861000582 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 1356861000583 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1356861000584 nudix motif; other site 1356861000585 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1356861000586 substrate binding site [chemical binding]; other site 1356861000587 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1356861000588 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1356861000589 phosphate binding site [ion binding]; other site 1356861000590 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1356861000591 dimer interface [polypeptide binding]; other site 1356861000592 FMN binding site [chemical binding]; other site 1356861000593 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1356861000594 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1356861000595 HIGH motif; other site 1356861000596 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1356861000597 active site 1356861000598 KMSKS motif; other site 1356861000599 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1356861000600 rRNA interaction site [nucleotide binding]; other site 1356861000601 S8 interaction site; other site 1356861000602 putative laminin-1 binding site; other site 1356861000603 elongation factor Ts; Provisional; Region: tsf; PRK09377 1356861000604 UBA/TS-N domain; Region: UBA; pfam00627 1356861000605 Elongation factor TS; Region: EF_TS; pfam00889 1356861000606 Elongation factor TS; Region: EF_TS; pfam00889 1356861000607 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1356861000608 putative nucleotide binding site [chemical binding]; other site 1356861000609 uridine monophosphate binding site [chemical binding]; other site 1356861000610 homohexameric interface [polypeptide binding]; other site 1356861000611 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1356861000612 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1356861000613 hinge region; other site 1356861000614 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 1356861000615 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1356861000616 catalytic residue [active] 1356861000617 putative FPP diphosphate binding site; other site 1356861000618 putative FPP binding hydrophobic cleft; other site 1356861000619 dimer interface [polypeptide binding]; other site 1356861000620 putative IPP diphosphate binding site; other site 1356861000621 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1356861000622 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1356861000623 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1356861000624 trimer interface [polypeptide binding]; other site 1356861000625 active site 1356861000626 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1356861000627 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1356861000628 S17 interaction site [polypeptide binding]; other site 1356861000629 S8 interaction site; other site 1356861000630 16S rRNA interaction site [nucleotide binding]; other site 1356861000631 streptomycin interaction site [chemical binding]; other site 1356861000632 23S rRNA interaction site [nucleotide binding]; other site 1356861000633 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1356861000634 30S ribosomal protein S7; Validated; Region: PRK05302 1356861000635 elongation factor G; Reviewed; Region: PRK00007 1356861000636 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1356861000637 G1 box; other site 1356861000638 putative GEF interaction site [polypeptide binding]; other site 1356861000639 GTP/Mg2+ binding site [chemical binding]; other site 1356861000640 Switch I region; other site 1356861000641 G2 box; other site 1356861000642 G3 box; other site 1356861000643 Switch II region; other site 1356861000644 G4 box; other site 1356861000645 G5 box; other site 1356861000646 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1356861000647 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1356861000648 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1356861000649 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1356861000650 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1356861000651 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1356861000652 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1356861000653 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1356861000654 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1356861000655 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1356861000656 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1356861000657 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1356861000658 putative translocon binding site; other site 1356861000659 protein-rRNA interface [nucleotide binding]; other site 1356861000660 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1356861000661 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1356861000662 G-X-X-G motif; other site 1356861000663 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1356861000664 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1356861000665 23S rRNA interface [nucleotide binding]; other site 1356861000666 5S rRNA interface [nucleotide binding]; other site 1356861000667 putative antibiotic binding site [chemical binding]; other site 1356861000668 L25 interface [polypeptide binding]; other site 1356861000669 L27 interface [polypeptide binding]; other site 1356861000670 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1356861000671 23S rRNA interface [nucleotide binding]; other site 1356861000672 putative translocon interaction site; other site 1356861000673 signal recognition particle (SRP54) interaction site; other site 1356861000674 L23 interface [polypeptide binding]; other site 1356861000675 trigger factor interaction site; other site 1356861000676 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1356861000677 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1356861000678 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1356861000679 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1356861000680 RNA binding site [nucleotide binding]; other site 1356861000681 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1356861000682 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1356861000683 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1356861000684 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1356861000685 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1356861000686 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1356861000687 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1356861000688 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1356861000689 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1356861000690 23S rRNA interface [nucleotide binding]; other site 1356861000691 L21e interface [polypeptide binding]; other site 1356861000692 5S rRNA interface [nucleotide binding]; other site 1356861000693 L27 interface [polypeptide binding]; other site 1356861000694 L5 interface [polypeptide binding]; other site 1356861000695 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1356861000696 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1356861000697 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1356861000698 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1356861000699 23S rRNA binding site [nucleotide binding]; other site 1356861000700 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1356861000701 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1356861000702 SecY translocase; Region: SecY; pfam00344 1356861000703 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1356861000704 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1356861000705 30S ribosomal protein S11; Validated; Region: PRK05309 1356861000706 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1356861000707 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1356861000708 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1356861000709 RNA binding surface [nucleotide binding]; other site 1356861000710 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1356861000711 alphaNTD homodimer interface [polypeptide binding]; other site 1356861000712 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1356861000713 alphaNTD - beta interaction site [polypeptide binding]; other site 1356861000714 alphaNTD - beta' interaction site [polypeptide binding]; other site 1356861000715 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1356861000716 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1356861000717 heat shock protein 90; Provisional; Region: PRK05218 1356861000718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1356861000719 ATP binding site [chemical binding]; other site 1356861000720 Mg2+ binding site [ion binding]; other site 1356861000721 G-X-G motif; other site 1356861000722 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1356861000723 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1356861000724 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1356861000725 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1356861000726 nucleotide binding site [chemical binding]; other site 1356861000727 N-acetyl-L-glutamate binding site [chemical binding]; other site 1356861000728 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1356861000729 heterotetramer interface [polypeptide binding]; other site 1356861000730 active site pocket [active] 1356861000731 cleavage site 1356861000732 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1356861000733 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1356861000734 Arginine repressor [Transcription]; Region: ArgR; COG1438 1356861000735 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1356861000736 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1356861000737 Lyase; Region: Lyase_1; pfam00206 1356861000738 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1356861000739 tetramer interface [polypeptide binding]; other site 1356861000740 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1356861000741 argininosuccinate synthase; Provisional; Region: PRK13820 1356861000742 ANP binding site [chemical binding]; other site 1356861000743 Substrate Binding Site II [chemical binding]; other site 1356861000744 Substrate Binding Site I [chemical binding]; other site 1356861000745 hypothetical protein; Provisional; Region: PRK11588 1356861000746 CTP synthetase; Validated; Region: pyrG; PRK05380 1356861000747 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1356861000748 Catalytic site [active] 1356861000749 active site 1356861000750 UTP binding site [chemical binding]; other site 1356861000751 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1356861000752 active site 1356861000753 putative oxyanion hole; other site 1356861000754 catalytic triad [active] 1356861000755 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1356861000756 active site 1356861000757 multimer interface [polypeptide binding]; other site 1356861000758 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1356861000759 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1356861000760 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1356861000761 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1356861000762 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1356861000763 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1356861000764 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1356861000765 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1356861000766 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1356861000767 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1356861000768 FAD binding pocket [chemical binding]; other site 1356861000769 FAD binding motif [chemical binding]; other site 1356861000770 phosphate binding motif [ion binding]; other site 1356861000771 beta-alpha-beta structure motif; other site 1356861000772 NAD binding pocket [chemical binding]; other site 1356861000773 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 1356861000774 SnoaL-like domain; Region: SnoaL_2; pfam12680 1356861000775 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1356861000776 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1356861000777 ProQ/FINO family; Region: ProQ; pfam04352 1356861000778 Cation transport protein; Region: TrkH; cl17365 1356861000779 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1356861000780 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1356861000781 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1356861000782 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1356861000783 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1356861000784 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1356861000785 lysine transporter; Provisional; Region: PRK10836 1356861000786 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1356861000787 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1356861000788 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1356861000789 putative active site [active] 1356861000790 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1356861000791 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1356861000792 Na binding site [ion binding]; other site 1356861000793 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1356861000794 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1356861000795 DXD motif; other site 1356861000796 Domain of unknown function DUF21; Region: DUF21; pfam01595 1356861000797 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1356861000798 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1356861000799 Transporter associated domain; Region: CorC_HlyC; cl08393 1356861000800 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1356861000801 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1356861000802 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1356861000803 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1356861000804 active site 1356861000805 HIGH motif; other site 1356861000806 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1356861000807 KMSKS motif; other site 1356861000808 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1356861000809 tRNA binding surface [nucleotide binding]; other site 1356861000810 anticodon binding site; other site 1356861000811 HemK family putative methylases; Region: hemK_fam; TIGR00536 1356861000812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1356861000813 S-adenosylmethionine binding site [chemical binding]; other site 1356861000814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1356861000815 Coenzyme A binding pocket [chemical binding]; other site 1356861000816 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1356861000817 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1356861000818 catalytic residue [active] 1356861000819 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1356861000820 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1356861000821 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1356861000822 VacJ like lipoprotein; Region: VacJ; cl01073 1356861000823 BolA-like protein; Region: BolA; cl00386 1356861000824 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1356861000825 anti sigma factor interaction site; other site 1356861000826 regulatory phosphorylation site [posttranslational modification]; other site 1356861000827 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1356861000828 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1356861000829 mce related protein; Region: MCE; pfam02470 1356861000830 Permease; Region: Permease; pfam02405 1356861000831 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1356861000832 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1356861000833 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1356861000834 Walker A/P-loop; other site 1356861000835 ATP binding site [chemical binding]; other site 1356861000836 Q-loop/lid; other site 1356861000837 ABC transporter signature motif; other site 1356861000838 Walker B; other site 1356861000839 D-loop; other site 1356861000840 H-loop/switch region; other site 1356861000841 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1356861000842 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1356861000843 Switch I; other site 1356861000844 Switch II; other site 1356861000845 septum formation inhibitor; Reviewed; Region: minC; PRK04804 1356861000846 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1356861000847 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1356861000848 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1356861000849 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1356861000850 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 1356861000851 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1356861000852 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1356861000853 ssDNA binding site; other site 1356861000854 generic binding surface II; other site 1356861000855 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1356861000856 ATP binding site [chemical binding]; other site 1356861000857 putative Mg++ binding site [ion binding]; other site 1356861000858 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1356861000859 nucleotide binding region [chemical binding]; other site 1356861000860 ATP-binding site [chemical binding]; other site 1356861000861 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1356861000862 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1356861000863 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1356861000864 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1356861000865 nudix motif; other site 1356861000866 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 1356861000867 ArsC family; Region: ArsC; pfam03960 1356861000868 catalytic residue [active] 1356861000869 hypothetical protein; Validated; Region: PRK09039 1356861000870 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1356861000871 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1356861000872 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 1356861000873 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1356861000874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861000875 homodimer interface [polypeptide binding]; other site 1356861000876 catalytic residue [active] 1356861000877 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 1356861000878 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1356861000879 TrkA-C domain; Region: TrkA_C; pfam02080 1356861000880 TrkA-C domain; Region: TrkA_C; pfam02080 1356861000881 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1356861000882 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1356861000883 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1356861000884 ligand binding site [chemical binding]; other site 1356861000885 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1356861000886 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1356861000887 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1356861000888 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1356861000889 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1356861000890 homotrimer interaction site [polypeptide binding]; other site 1356861000891 active site 1356861000892 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1356861000893 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1356861000894 TolQ protein; Region: tolQ; TIGR02796 1356861000895 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1356861000896 TolR protein; Region: tolR; TIGR02801 1356861000897 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1356861000898 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1356861000899 TolB amino-terminal domain; Region: TolB_N; pfam04052 1356861000900 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1356861000901 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1356861000902 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1356861000903 ligand binding site [chemical binding]; other site 1356861000904 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 1356861000905 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 1356861000906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1356861000907 YheO-like PAS domain; Region: PAS_6; pfam08348 1356861000908 HTH domain; Region: HTH_22; pfam13309 1356861000909 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1356861000910 hypothetical protein; Provisional; Region: PRK10621 1356861000911 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1356861000912 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1356861000913 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1356861000914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1356861000915 Coenzyme A binding pocket [chemical binding]; other site 1356861000916 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 1356861000917 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1356861000918 thiamine phosphate binding site [chemical binding]; other site 1356861000919 active site 1356861000920 pyrophosphate binding site [ion binding]; other site 1356861000921 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1356861000922 substrate binding site [chemical binding]; other site 1356861000923 multimerization interface [polypeptide binding]; other site 1356861000924 ATP binding site [chemical binding]; other site 1356861000925 thiamine monophosphate kinase; Provisional; Region: PRK05731 1356861000926 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1356861000927 ATP binding site [chemical binding]; other site 1356861000928 dimerization interface [polypeptide binding]; other site 1356861000929 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1356861000930 substrate binding site [chemical binding]; other site 1356861000931 dimer interface [polypeptide binding]; other site 1356861000932 ATP binding site [chemical binding]; other site 1356861000933 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1356861000934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1356861000935 non-specific DNA binding site [nucleotide binding]; other site 1356861000936 salt bridge; other site 1356861000937 sequence-specific DNA binding site [nucleotide binding]; other site 1356861000938 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1356861000939 Protein of unknown function (DUF423); Region: DUF423; cl01008 1356861000940 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 1356861000941 UbiA prenyltransferase family; Region: UbiA; pfam01040 1356861000942 Chorismate lyase; Region: Chor_lyase; cl01230 1356861000943 ribonuclease PH; Reviewed; Region: rph; PRK00173 1356861000944 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1356861000945 hexamer interface [polypeptide binding]; other site 1356861000946 active site 1356861000947 heat shock protein HtpX; Provisional; Region: PRK02870 1356861000948 LemA family; Region: LemA; cl00742 1356861000949 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1356861000950 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1356861000951 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1356861000952 putative dimerization interface [polypeptide binding]; other site 1356861000953 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1356861000954 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1356861000955 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1356861000956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1356861000957 putative DNA binding site [nucleotide binding]; other site 1356861000958 putative Zn2+ binding site [ion binding]; other site 1356861000959 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1356861000960 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1356861000961 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1356861000962 Colicin V production protein; Region: Colicin_V; pfam02674 1356861000963 DNA repair protein RadA; Provisional; Region: PRK11823 1356861000964 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1356861000965 Walker A motif/ATP binding site; other site 1356861000966 ATP binding site [chemical binding]; other site 1356861000967 Walker B motif; other site 1356861000968 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1356861000969 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1356861000970 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1356861000971 Tetramer interface [polypeptide binding]; other site 1356861000972 active site 1356861000973 FMN-binding site [chemical binding]; other site 1356861000974 PQ loop repeat; Region: PQ-loop; pfam04193 1356861000975 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1356861000976 SelR domain; Region: SelR; pfam01641 1356861000977 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1356861000978 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1356861000979 E-class dimer interface [polypeptide binding]; other site 1356861000980 P-class dimer interface [polypeptide binding]; other site 1356861000981 active site 1356861000982 Cu2+ binding site [ion binding]; other site 1356861000983 Zn2+ binding site [ion binding]; other site 1356861000984 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1356861000985 Cupin domain; Region: Cupin_2; cl17218 1356861000986 aspartate aminotransferase; Provisional; Region: PRK07568 1356861000987 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1356861000988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861000989 homodimer interface [polypeptide binding]; other site 1356861000990 catalytic residue [active] 1356861000991 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1356861000992 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1356861000993 Walker A/P-loop; other site 1356861000994 ATP binding site [chemical binding]; other site 1356861000995 Q-loop/lid; other site 1356861000996 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1356861000997 ABC transporter signature motif; other site 1356861000998 Walker B; other site 1356861000999 D-loop; other site 1356861001000 H-loop/switch region; other site 1356861001001 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 1356861001002 Pilin (bacterial filament); Region: Pilin; pfam00114 1356861001003 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 1356861001004 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1356861001005 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1356861001006 homodimer interface [polypeptide binding]; other site 1356861001007 NADP binding site [chemical binding]; other site 1356861001008 substrate binding site [chemical binding]; other site 1356861001009 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1356861001010 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1356861001011 dimerization interface [polypeptide binding]; other site 1356861001012 putative ATP binding site [chemical binding]; other site 1356861001013 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1356861001014 active site 1356861001015 ATP binding site [chemical binding]; other site 1356861001016 substrate binding site [chemical binding]; other site 1356861001017 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1356861001018 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1356861001019 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1356861001020 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1356861001021 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1356861001022 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1356861001023 active site 1356861001024 substrate binding site [chemical binding]; other site 1356861001025 cosubstrate binding site; other site 1356861001026 catalytic site [active] 1356861001027 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1356861001028 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1356861001029 ATP-grasp domain; Region: ATP-grasp; pfam02222 1356861001030 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1356861001031 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1356861001032 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1356861001033 active site 1356861001034 Zn binding site [ion binding]; other site 1356861001035 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 1356861001036 DNA topoisomerase I; Validated; Region: PRK06599 1356861001037 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1356861001038 active site 1356861001039 interdomain interaction site; other site 1356861001040 putative metal-binding site [ion binding]; other site 1356861001041 nucleotide binding site [chemical binding]; other site 1356861001042 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1356861001043 domain I; other site 1356861001044 DNA binding groove [nucleotide binding] 1356861001045 phosphate binding site [ion binding]; other site 1356861001046 domain II; other site 1356861001047 domain III; other site 1356861001048 nucleotide binding site [chemical binding]; other site 1356861001049 catalytic site [active] 1356861001050 domain IV; other site 1356861001051 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1356861001052 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1356861001053 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1356861001054 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1356861001055 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1356861001056 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1356861001057 P-loop; other site 1356861001058 Magnesium ion binding site [ion binding]; other site 1356861001059 ParB-like nuclease domain; Region: ParB; smart00470 1356861001060 KorB domain; Region: KorB; pfam08535 1356861001061 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1356861001062 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1356861001063 catalytic triad [active] 1356861001064 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1356861001065 active site 1356861001066 catalytic triad [active] 1356861001067 oxyanion hole [active] 1356861001068 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1356861001069 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1356861001070 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1356861001071 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1356861001072 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1356861001073 active site 1356861001074 HIGH motif; other site 1356861001075 nucleotide binding site [chemical binding]; other site 1356861001076 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1356861001077 active site 1356861001078 KMSKS motif; other site 1356861001079 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1356861001080 tRNA binding surface [nucleotide binding]; other site 1356861001081 anticodon binding site; other site 1356861001082 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1356861001083 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1356861001084 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1356861001085 active site 1356861001086 Riboflavin kinase; Region: Flavokinase; pfam01687 1356861001087 malate dehydrogenase; Provisional; Region: PRK13529 1356861001088 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1356861001089 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1356861001090 NAD(P) binding pocket [chemical binding]; other site 1356861001091 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 1356861001092 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 1356861001093 GTP-binding protein Der; Reviewed; Region: PRK00093 1356861001094 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1356861001095 G1 box; other site 1356861001096 GTP/Mg2+ binding site [chemical binding]; other site 1356861001097 Switch I region; other site 1356861001098 G2 box; other site 1356861001099 Switch II region; other site 1356861001100 G3 box; other site 1356861001101 G4 box; other site 1356861001102 G5 box; other site 1356861001103 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1356861001104 G1 box; other site 1356861001105 GTP/Mg2+ binding site [chemical binding]; other site 1356861001106 Switch I region; other site 1356861001107 G2 box; other site 1356861001108 G3 box; other site 1356861001109 Switch II region; other site 1356861001110 G4 box; other site 1356861001111 G5 box; other site 1356861001112 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1356861001113 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1356861001114 putative active site [active] 1356861001115 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 1356861001116 FAD binding domain; Region: FAD_binding_4; pfam01565 1356861001117 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1356861001118 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1356861001119 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1356861001120 nucleotide binding site/active site [active] 1356861001121 HIT family signature motif; other site 1356861001122 catalytic residue [active] 1356861001123 ABC1 family; Region: ABC1; cl17513 1356861001124 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1356861001125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1356861001126 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1356861001127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1356861001128 S-adenosylmethionine binding site [chemical binding]; other site 1356861001129 Glucokinase; Region: Glucokinase; pfam02685 1356861001130 glucokinase, proteobacterial type; Region: glk; TIGR00749 1356861001131 Intracellular septation protein A; Region: IspA; pfam04279 1356861001132 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1356861001133 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1356861001134 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1356861001135 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1356861001136 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1356861001137 active site 1356861001138 HIGH motif; other site 1356861001139 KMSKS motif; other site 1356861001140 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1356861001141 tRNA binding surface [nucleotide binding]; other site 1356861001142 anticodon binding site; other site 1356861001143 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1356861001144 dimer interface [polypeptide binding]; other site 1356861001145 putative tRNA-binding site [nucleotide binding]; other site 1356861001146 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1356861001147 Peptidase family M50; Region: Peptidase_M50; pfam02163 1356861001148 active site 1356861001149 putative substrate binding region [chemical binding]; other site 1356861001150 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1356861001151 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 1356861001152 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1356861001153 active site 1356861001154 nucleotide binding site [chemical binding]; other site 1356861001155 HIGH motif; other site 1356861001156 KMSKS motif; other site 1356861001157 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1356861001158 nudix motif; other site 1356861001159 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 1356861001160 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1356861001161 Substrate binding site; other site 1356861001162 Mg++ binding site; other site 1356861001163 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1356861001164 active site 1356861001165 substrate binding site [chemical binding]; other site 1356861001166 CoA binding site [chemical binding]; other site 1356861001167 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1356861001168 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1356861001169 glutaminase active site [active] 1356861001170 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1356861001171 dimer interface [polypeptide binding]; other site 1356861001172 active site 1356861001173 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1356861001174 dimer interface [polypeptide binding]; other site 1356861001175 active site 1356861001176 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1356861001177 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1356861001178 DNA-binding site [nucleotide binding]; DNA binding site 1356861001179 RNA-binding motif; other site 1356861001180 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1356861001181 active site 1356861001182 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1356861001183 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1356861001184 CAP-like domain; other site 1356861001185 active site 1356861001186 primary dimer interface [polypeptide binding]; other site 1356861001187 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1356861001188 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1356861001189 lytic murein transglycosylase; Provisional; Region: PRK11619 1356861001190 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1356861001191 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1356861001192 catalytic residue [active] 1356861001193 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1356861001194 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1356861001195 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1356861001196 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1356861001197 putative active site [active] 1356861001198 putative PHP Thumb interface [polypeptide binding]; other site 1356861001199 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1356861001200 generic binding surface II; other site 1356861001201 generic binding surface I; other site 1356861001202 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1356861001203 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1356861001204 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1356861001205 FtsX-like permease family; Region: FtsX; pfam02687 1356861001206 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1356861001207 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1356861001208 Walker A/P-loop; other site 1356861001209 ATP binding site [chemical binding]; other site 1356861001210 Q-loop/lid; other site 1356861001211 ABC transporter signature motif; other site 1356861001212 Walker B; other site 1356861001213 D-loop; other site 1356861001214 H-loop/switch region; other site 1356861001215 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1356861001216 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1356861001217 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1356861001218 homodimer interface [polypeptide binding]; other site 1356861001219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861001220 catalytic residue [active] 1356861001221 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1356861001222 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1356861001223 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1356861001224 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1356861001225 lipoyl attachment site [posttranslational modification]; other site 1356861001226 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1356861001227 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1356861001228 tetramer interface [polypeptide binding]; other site 1356861001229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861001230 catalytic residue [active] 1356861001231 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1356861001232 tetramer interface [polypeptide binding]; other site 1356861001233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861001234 catalytic residue [active] 1356861001235 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1356861001236 oxyanion hole [active] 1356861001237 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1356861001238 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1356861001239 homodimer interface [polypeptide binding]; other site 1356861001240 substrate-cofactor binding pocket; other site 1356861001241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861001242 catalytic residue [active] 1356861001243 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1356861001244 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1356861001245 pullulanase, type I; Region: pulA_typeI; TIGR02104 1356861001246 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1356861001247 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1356861001248 Ca binding site [ion binding]; other site 1356861001249 active site 1356861001250 catalytic site [active] 1356861001251 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 1356861001252 glycogen branching enzyme; Provisional; Region: PRK12313 1356861001253 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1356861001254 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1356861001255 active site 1356861001256 catalytic site [active] 1356861001257 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1356861001258 phosphoglucomutase; Region: PLN02307 1356861001259 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 1356861001260 substrate binding site [chemical binding]; other site 1356861001261 dimer interface [polypeptide binding]; other site 1356861001262 active site 1356861001263 metal binding site [ion binding]; metal-binding site 1356861001264 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1356861001265 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1356861001266 ligand binding site; other site 1356861001267 oligomer interface; other site 1356861001268 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1356861001269 dimer interface [polypeptide binding]; other site 1356861001270 N-terminal domain interface [polypeptide binding]; other site 1356861001271 sulfate 1 binding site; other site 1356861001272 glycogen synthase; Provisional; Region: glgA; PRK00654 1356861001273 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1356861001274 ADP-binding pocket [chemical binding]; other site 1356861001275 homodimer interface [polypeptide binding]; other site 1356861001276 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1356861001277 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1356861001278 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1356861001279 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1356861001280 dimer interface [polypeptide binding]; other site 1356861001281 motif 1; other site 1356861001282 active site 1356861001283 motif 2; other site 1356861001284 motif 3; other site 1356861001285 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1356861001286 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1356861001287 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1356861001288 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1356861001289 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1356861001290 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1356861001291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1356861001292 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1356861001293 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1356861001294 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1356861001295 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1356861001296 nucleotide binding site [chemical binding]; other site 1356861001297 substrate binding site [chemical binding]; other site 1356861001298 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1356861001299 dimer interface [polypeptide binding]; other site 1356861001300 putative threonine allosteric regulatory site; other site 1356861001301 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1356861001302 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1356861001303 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1356861001304 homoserine kinase; Provisional; Region: PRK01212 1356861001305 threonine synthase; Validated; Region: PRK09225 1356861001306 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1356861001307 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1356861001308 catalytic residue [active] 1356861001309 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1356861001310 putative active site [active] 1356861001311 putative metal binding site [ion binding]; other site 1356861001312 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1356861001313 active site 1356861001314 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 1356861001315 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1356861001316 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1356861001317 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1356861001318 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1356861001319 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1356861001320 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1356861001321 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1356861001322 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1356861001323 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1356861001324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861001325 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1356861001326 putative substrate translocation pore; other site 1356861001327 ABC transporter ATPase component; Reviewed; Region: PRK11147 1356861001328 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1356861001329 Walker A/P-loop; other site 1356861001330 ATP binding site [chemical binding]; other site 1356861001331 Q-loop/lid; other site 1356861001332 ABC transporter signature motif; other site 1356861001333 Walker B; other site 1356861001334 D-loop; other site 1356861001335 H-loop/switch region; other site 1356861001336 ABC transporter; Region: ABC_tran_2; pfam12848 1356861001337 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1356861001338 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1356861001339 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1356861001340 active site 1356861001341 HIGH motif; other site 1356861001342 nucleotide binding site [chemical binding]; other site 1356861001343 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1356861001344 KMSKS motif; other site 1356861001345 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1356861001346 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 1356861001347 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1356861001348 active site 1356861001349 metal-binding site [ion binding] 1356861001350 nucleotide-binding site [chemical binding]; other site 1356861001351 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1356861001352 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1356861001353 Mg++ binding site [ion binding]; other site 1356861001354 putative catalytic motif [active] 1356861001355 putative substrate binding site [chemical binding]; other site 1356861001356 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 1356861001357 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1356861001358 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1356861001359 cell division protein FtsW; Region: ftsW; TIGR02614 1356861001360 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1356861001361 Putative Catalytic site; other site 1356861001362 DXD motif; other site 1356861001363 oxidative damage protection protein; Provisional; Region: PRK05408 1356861001364 DsrC like protein; Region: DsrC; pfam04358 1356861001365 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1356861001366 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1356861001367 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1356861001368 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1356861001369 dimer interface [polypeptide binding]; other site 1356861001370 N-terminal domain interface [polypeptide binding]; other site 1356861001371 putative inner membrane peptidase; Provisional; Region: PRK11778 1356861001372 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1356861001373 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1356861001374 tandem repeat interface [polypeptide binding]; other site 1356861001375 oligomer interface [polypeptide binding]; other site 1356861001376 active site residues [active] 1356861001377 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1356861001378 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1356861001379 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1356861001380 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 1356861001381 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1356861001382 dimer interface [polypeptide binding]; other site 1356861001383 active site 1356861001384 Schiff base residues; other site 1356861001385 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1356861001386 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1356861001387 POT family; Region: PTR2; cl17359 1356861001388 POT family; Region: PTR2; cl17359 1356861001389 POT family; Region: PTR2; cl17359 1356861001390 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1356861001391 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1356861001392 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1356861001393 active site 1356861001394 HIGH motif; other site 1356861001395 nucleotide binding site [chemical binding]; other site 1356861001396 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1356861001397 KMSK motif region; other site 1356861001398 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1356861001399 tRNA binding surface [nucleotide binding]; other site 1356861001400 anticodon binding site; other site 1356861001401 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1356861001402 SurA N-terminal domain; Region: SurA_N; pfam09312 1356861001403 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1356861001404 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1356861001405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1356861001406 S-adenosylmethionine binding site [chemical binding]; other site 1356861001407 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1356861001408 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1356861001409 active site 1356861001410 metal binding site [ion binding]; metal-binding site 1356861001411 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1356861001412 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1356861001413 trimer interface [polypeptide binding]; other site 1356861001414 active site 1356861001415 dimer interface [polypeptide binding]; other site 1356861001416 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1356861001417 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1356861001418 carboxyltransferase (CT) interaction site; other site 1356861001419 biotinylation site [posttranslational modification]; other site 1356861001420 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1356861001421 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1356861001422 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1356861001423 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1356861001424 Helix-turn-helix domain; Region: HTH_25; pfam13413 1356861001425 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1356861001426 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1356861001427 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1356861001428 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 1356861001429 motif 1; other site 1356861001430 dimer interface [polypeptide binding]; other site 1356861001431 active site 1356861001432 motif 2; other site 1356861001433 motif 3; other site 1356861001434 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1356861001435 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1356861001436 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1356861001437 DHH family; Region: DHH; pfam01368 1356861001438 DHHA1 domain; Region: DHHA1; pfam02272 1356861001439 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1356861001440 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1356861001441 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1356861001442 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1356861001443 GTPase RsgA; Reviewed; Region: PRK00098 1356861001444 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1356861001445 RNA binding site [nucleotide binding]; other site 1356861001446 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1356861001447 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1356861001448 GTP/Mg2+ binding site [chemical binding]; other site 1356861001449 G4 box; other site 1356861001450 G5 box; other site 1356861001451 G1 box; other site 1356861001452 Switch I region; other site 1356861001453 G2 box; other site 1356861001454 G3 box; other site 1356861001455 Switch II region; other site 1356861001456 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 1356861001457 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1356861001458 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1356861001459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1356861001460 ATP binding site [chemical binding]; other site 1356861001461 Mg2+ binding site [ion binding]; other site 1356861001462 G-X-G motif; other site 1356861001463 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1356861001464 ATP binding site [chemical binding]; other site 1356861001465 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1356861001466 thioredoxin reductase; Provisional; Region: PRK10262 1356861001467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1356861001468 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1356861001469 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1356861001470 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1356861001471 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1356861001472 motif II; other site 1356861001473 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1356861001474 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1356861001475 phosphate binding site [ion binding]; other site 1356861001476 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1356861001477 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 1356861001478 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 1356861001479 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1356861001480 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1356861001481 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1356861001482 CoA binding domain; Region: CoA_binding; smart00881 1356861001483 CoA-ligase; Region: Ligase_CoA; pfam00549 1356861001484 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1356861001485 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1356861001486 CoA-ligase; Region: Ligase_CoA; pfam00549 1356861001487 TIGR03546 family protein; Region: TIGR03546 1356861001488 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1356861001489 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1356861001490 FMN binding site [chemical binding]; other site 1356861001491 active site 1356861001492 catalytic residues [active] 1356861001493 substrate binding site [chemical binding]; other site 1356861001494 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1356861001495 putative active site pocket [active] 1356861001496 dimerization interface [polypeptide binding]; other site 1356861001497 putative catalytic residue [active] 1356861001498 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1356861001499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1356861001500 ATP binding site [chemical binding]; other site 1356861001501 Mg2+ binding site [ion binding]; other site 1356861001502 G-X-G motif; other site 1356861001503 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1356861001504 anchoring element; other site 1356861001505 dimer interface [polypeptide binding]; other site 1356861001506 ATP binding site [chemical binding]; other site 1356861001507 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1356861001508 active site 1356861001509 putative metal-binding site [ion binding]; other site 1356861001510 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1356861001511 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1356861001512 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1356861001513 active site 1356861001514 multimer interface [polypeptide binding]; other site 1356861001515 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1356861001516 predicted active site [active] 1356861001517 catalytic triad [active] 1356861001518 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1356861001519 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1356861001520 DNA binding site [nucleotide binding] 1356861001521 catalytic residue [active] 1356861001522 H2TH interface [polypeptide binding]; other site 1356861001523 putative catalytic residues [active] 1356861001524 turnover-facilitating residue; other site 1356861001525 intercalation triad [nucleotide binding]; other site 1356861001526 8OG recognition residue [nucleotide binding]; other site 1356861001527 putative reading head residues; other site 1356861001528 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1356861001529 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1356861001530 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1356861001531 AMP-binding enzyme; Region: AMP-binding; pfam00501 1356861001532 acyl-activating enzyme (AAE) consensus motif; other site 1356861001533 putative AMP binding site [chemical binding]; other site 1356861001534 MraW methylase family; Region: Methyltransf_5; cl17771 1356861001535 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1356861001536 Cell division protein FtsL; Region: FtsL; cl11433 1356861001537 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1356861001538 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1356861001539 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1356861001540 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1356861001541 16S/18S rRNA binding site [nucleotide binding]; other site 1356861001542 S13e-L30e interaction site [polypeptide binding]; other site 1356861001543 25S rRNA binding site [nucleotide binding]; other site 1356861001544 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1356861001545 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1356861001546 RNase E interface [polypeptide binding]; other site 1356861001547 trimer interface [polypeptide binding]; other site 1356861001548 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1356861001549 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1356861001550 RNase E interface [polypeptide binding]; other site 1356861001551 trimer interface [polypeptide binding]; other site 1356861001552 active site 1356861001553 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1356861001554 putative nucleic acid binding region [nucleotide binding]; other site 1356861001555 G-X-X-G motif; other site 1356861001556 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1356861001557 RNA binding site [nucleotide binding]; other site 1356861001558 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1356861001559 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1356861001560 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1356861001561 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1356861001562 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1356861001563 ATP-binding site [chemical binding]; other site 1356861001564 Sugar specificity; other site 1356861001565 Pyrimidine base specificity; other site 1356861001566 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1356861001567 TRAM domain; Region: TRAM; cl01282 1356861001568 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1356861001569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1356861001570 S-adenosylmethionine binding site [chemical binding]; other site 1356861001571 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1356861001572 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1356861001573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861001574 putative substrate translocation pore; other site 1356861001575 enolase; Provisional; Region: eno; PRK00077 1356861001576 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1356861001577 dimer interface [polypeptide binding]; other site 1356861001578 metal binding site [ion binding]; metal-binding site 1356861001579 substrate binding pocket [chemical binding]; other site 1356861001580 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1356861001581 Septum formation initiator; Region: DivIC; cl17659 1356861001582 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1356861001583 substrate binding site; other site 1356861001584 dimer interface; other site 1356861001585 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1356861001586 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1356861001587 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1356861001588 NAD(P) binding site [chemical binding]; other site 1356861001589 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1356861001590 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1356861001591 substrate-cofactor binding pocket; other site 1356861001592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861001593 catalytic residue [active] 1356861001594 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1356861001595 putative efflux protein, MATE family; Region: matE; TIGR00797 1356861001596 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 1356861001597 putative substrate binding pocket [chemical binding]; other site 1356861001598 trimer interface [polypeptide binding]; other site 1356861001599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861001600 metabolite-proton symporter; Region: 2A0106; TIGR00883 1356861001601 putative substrate translocation pore; other site 1356861001602 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 1356861001603 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1356861001604 Zn2+ binding site [ion binding]; other site 1356861001605 Mg2+ binding site [ion binding]; other site 1356861001606 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1356861001607 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1356861001608 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1356861001609 heme binding site [chemical binding]; other site 1356861001610 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1356861001611 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1356861001612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861001613 putative substrate translocation pore; other site 1356861001614 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1356861001615 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1356861001616 active site 1356861001617 catalytic site [active] 1356861001618 metal binding site [ion binding]; metal-binding site 1356861001619 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1356861001620 homotrimer interaction site [polypeptide binding]; other site 1356861001621 putative active site [active] 1356861001622 MAPEG family; Region: MAPEG; pfam01124 1356861001623 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1356861001624 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1356861001625 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1356861001626 Fic family protein [Function unknown]; Region: COG3177 1356861001627 Fic/DOC family; Region: Fic; pfam02661 1356861001628 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1356861001629 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1356861001630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1356861001631 Walker A/P-loop; other site 1356861001632 ATP binding site [chemical binding]; other site 1356861001633 Q-loop/lid; other site 1356861001634 ABC transporter signature motif; other site 1356861001635 Walker B; other site 1356861001636 D-loop; other site 1356861001637 H-loop/switch region; other site 1356861001638 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1356861001639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1356861001640 Walker A/P-loop; other site 1356861001641 ATP binding site [chemical binding]; other site 1356861001642 Q-loop/lid; other site 1356861001643 ABC transporter signature motif; other site 1356861001644 Walker B; other site 1356861001645 D-loop; other site 1356861001646 H-loop/switch region; other site 1356861001647 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1356861001648 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1356861001649 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1356861001650 ROK family; Region: ROK; pfam00480 1356861001651 seryl-tRNA synthetase; Provisional; Region: PRK05431 1356861001652 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1356861001653 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1356861001654 dimer interface [polypeptide binding]; other site 1356861001655 active site 1356861001656 motif 1; other site 1356861001657 motif 2; other site 1356861001658 motif 3; other site 1356861001659 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1356861001660 phosphoglyceromutase; Provisional; Region: PRK05434 1356861001661 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1356861001662 FAD binding domain; Region: FAD_binding_4; pfam01565 1356861001663 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1356861001664 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1356861001665 active site 1356861001666 catalytic motif [active] 1356861001667 Zn binding site [ion binding]; other site 1356861001668 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1356861001669 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1356861001670 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1356861001671 active site 1356861001672 dinuclear metal binding site [ion binding]; other site 1356861001673 dimerization interface [polypeptide binding]; other site 1356861001674 Predicted membrane protein [Function unknown]; Region: COG2860 1356861001675 UPF0126 domain; Region: UPF0126; pfam03458 1356861001676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1356861001677 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1356861001678 S-adenosylmethionine binding site [chemical binding]; other site 1356861001679 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1356861001680 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1356861001681 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1356861001682 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1356861001683 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1356861001684 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1356861001685 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1356861001686 Predicted permeases [General function prediction only]; Region: COG0795 1356861001687 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1356861001688 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1356861001689 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1356861001690 interface (dimer of trimers) [polypeptide binding]; other site 1356861001691 Substrate-binding/catalytic site; other site 1356861001692 Zn-binding sites [ion binding]; other site 1356861001693 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1356861001694 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1356861001695 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1356861001696 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1356861001697 active site 1356861001698 Thiamine pyrophosphokinase; Region: TPK; cd07995 1356861001699 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1356861001700 active site 1356861001701 dimerization interface [polypeptide binding]; other site 1356861001702 thiamine binding site [chemical binding]; other site 1356861001703 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1356861001704 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1356861001705 active site 1356861001706 dimer interface [polypeptide binding]; other site 1356861001707 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1356861001708 dimer interface [polypeptide binding]; other site 1356861001709 active site 1356861001710 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1356861001711 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1356861001712 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1356861001713 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1356861001714 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1356861001715 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1356861001716 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1356861001717 FtsH Extracellular; Region: FtsH_ext; pfam06480 1356861001718 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1356861001719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1356861001720 Walker A motif; other site 1356861001721 ATP binding site [chemical binding]; other site 1356861001722 Walker B motif; other site 1356861001723 arginine finger; other site 1356861001724 Peptidase family M41; Region: Peptidase_M41; pfam01434 1356861001725 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1356861001726 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1356861001727 LPP20 lipoprotein; Region: LPP20; pfam02169 1356861001728 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1356861001729 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1356861001730 ATP binding site [chemical binding]; other site 1356861001731 putative Mg++ binding site [ion binding]; other site 1356861001732 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1356861001733 SEC-C motif; Region: SEC-C; pfam02810 1356861001734 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1356861001735 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1356861001736 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1356861001737 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1356861001738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1356861001739 dimer interface [polypeptide binding]; other site 1356861001740 conserved gate region; other site 1356861001741 putative PBP binding loops; other site 1356861001742 ABC-ATPase subunit interface; other site 1356861001743 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1356861001744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1356861001745 dimer interface [polypeptide binding]; other site 1356861001746 conserved gate region; other site 1356861001747 putative PBP binding loops; other site 1356861001748 ABC-ATPase subunit interface; other site 1356861001749 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1356861001750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1356861001751 Walker A/P-loop; other site 1356861001752 ATP binding site [chemical binding]; other site 1356861001753 Q-loop/lid; other site 1356861001754 ABC transporter signature motif; other site 1356861001755 Walker B; other site 1356861001756 D-loop; other site 1356861001757 H-loop/switch region; other site 1356861001758 TOBE domain; Region: TOBE_2; pfam08402 1356861001759 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1356861001760 hypothetical protein; Provisional; Region: PRK14013 1356861001761 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1356861001762 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 1356861001763 putative C-terminal domain interface [polypeptide binding]; other site 1356861001764 putative GSH binding site [chemical binding]; other site 1356861001765 putative dimer interface [polypeptide binding]; other site 1356861001766 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1356861001767 dimer interface [polypeptide binding]; other site 1356861001768 substrate binding pocket (H-site) [chemical binding]; other site 1356861001769 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 1356861001770 putative N-terminal domain interface [polypeptide binding]; other site 1356861001771 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1356861001772 POT family; Region: PTR2; cl17359 1356861001773 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1356861001774 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1356861001775 active site 1356861001776 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1356861001777 dimer interface [polypeptide binding]; other site 1356861001778 substrate binding site [chemical binding]; other site 1356861001779 catalytic residues [active] 1356861001780 amino acid transporter; Region: 2A0306; TIGR00909 1356861001781 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1356861001782 Prephenate dehydratase; Region: PDT; pfam00800 1356861001783 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1356861001784 putative L-Phe binding site [chemical binding]; other site 1356861001785 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1356861001786 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1356861001787 active site 1356861001788 metal binding site [ion binding]; metal-binding site 1356861001789 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1356861001790 Protein of unknown function DUF45; Region: DUF45; pfam01863 1356861001791 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1356861001792 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1356861001793 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1356861001794 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1356861001795 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1356861001796 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1356861001797 catalytic residue [active] 1356861001798 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1356861001799 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 1356861001800 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1356861001801 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1356861001802 active site 1356861001803 (T/H)XGH motif; other site 1356861001804 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1356861001805 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1356861001806 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1356861001807 ligand binding site [chemical binding]; other site 1356861001808 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1356861001809 Walker B motif; other site 1356861001810 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1356861001811 Walker A motif; other site 1356861001812 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1356861001813 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1356861001814 putative active site [active] 1356861001815 catalytic site [active] 1356861001816 putative metal binding site [ion binding]; other site 1356861001817 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1356861001818 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1356861001819 putative MPT binding site; other site 1356861001820 cyanophycin synthetase; Provisional; Region: PRK14016 1356861001821 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1356861001822 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1356861001823 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1356861001824 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1356861001825 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1356861001826 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1356861001827 homotrimer interaction site [polypeptide binding]; other site 1356861001828 zinc binding site [ion binding]; other site 1356861001829 CDP-binding sites; other site 1356861001830 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1356861001831 active site residue [active] 1356861001832 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1356861001833 active site residue [active] 1356861001834 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1356861001835 aromatic amino acid transport protein; Region: araaP; TIGR00837 1356861001836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1356861001837 Walker A/P-loop; other site 1356861001838 ATP binding site [chemical binding]; other site 1356861001839 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1356861001840 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1356861001841 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1356861001842 Isochorismatase family; Region: Isochorismatase; pfam00857 1356861001843 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1356861001844 catalytic triad [active] 1356861001845 conserved cis-peptide bond; other site 1356861001846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1356861001847 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1356861001848 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1356861001849 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1356861001850 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1356861001851 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1356861001852 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1356861001853 Protein export membrane protein; Region: SecD_SecF; pfam02355 1356861001854 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1356861001855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1356861001856 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1356861001857 DNA binding residues [nucleotide binding] 1356861001858 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1356861001859 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1356861001860 hinge; other site 1356861001861 active site 1356861001862 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1356861001863 RNA/DNA hybrid binding site [nucleotide binding]; other site 1356861001864 active site 1356861001865 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1356861001866 active site 1356861001867 homodimer interface [polypeptide binding]; other site 1356861001868 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1356861001869 active site clefts [active] 1356861001870 zinc binding site [ion binding]; other site 1356861001871 dimer interface [polypeptide binding]; other site 1356861001872 trigger factor; Provisional; Region: tig; PRK01490 1356861001873 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1356861001874 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1356861001875 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1356861001876 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1356861001877 oligomer interface [polypeptide binding]; other site 1356861001878 active site residues [active] 1356861001879 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1356861001880 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1356861001881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1356861001882 Walker A motif; other site 1356861001883 ATP binding site [chemical binding]; other site 1356861001884 Walker B motif; other site 1356861001885 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1356861001886 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1356861001887 IHF dimer interface [polypeptide binding]; other site 1356861001888 IHF - DNA interface [nucleotide binding]; other site 1356861001889 SurA N-terminal domain; Region: SurA_N_3; cl07813 1356861001890 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1356861001891 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1356861001892 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1356861001893 bacterial Hfq-like; Region: Hfq; cd01716 1356861001894 hexamer interface [polypeptide binding]; other site 1356861001895 Sm1 motif; other site 1356861001896 RNA binding site [nucleotide binding]; other site 1356861001897 Sm2 motif; other site 1356861001898 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1356861001899 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1356861001900 HflX GTPase family; Region: HflX; cd01878 1356861001901 G1 box; other site 1356861001902 GTP/Mg2+ binding site [chemical binding]; other site 1356861001903 Switch I region; other site 1356861001904 G2 box; other site 1356861001905 G3 box; other site 1356861001906 Switch II region; other site 1356861001907 G4 box; other site 1356861001908 G5 box; other site 1356861001909 hypothetical protein; Provisional; Region: PRK07588 1356861001910 hypothetical protein; Provisional; Region: PRK07588 1356861001911 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1356861001912 HflK protein; Region: hflK; TIGR01933 1356861001913 FtsH protease regulator HflC; Provisional; Region: PRK11029 1356861001914 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1356861001915 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1356861001916 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1356861001917 active site 1356861001918 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1356861001919 G1 box; other site 1356861001920 GTP/Mg2+ binding site [chemical binding]; other site 1356861001921 Switch I region; other site 1356861001922 G2 box; other site 1356861001923 G3 box; other site 1356861001924 Switch II region; other site 1356861001925 G4 box; other site 1356861001926 G5 box; other site 1356861001927 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1356861001928 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1356861001929 putative valine binding site [chemical binding]; other site 1356861001930 dimer interface [polypeptide binding]; other site 1356861001931 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1356861001932 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1356861001933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1356861001934 ATP binding site [chemical binding]; other site 1356861001935 putative Mg++ binding site [ion binding]; other site 1356861001936 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1356861001937 nucleotide binding region [chemical binding]; other site 1356861001938 ATP-binding site [chemical binding]; other site 1356861001939 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1356861001940 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1356861001941 YccA-like proteins; Region: YccA_like; cd10433 1356861001942 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 1356861001943 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1356861001944 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1356861001945 minor groove reading motif; other site 1356861001946 helix-hairpin-helix signature motif; other site 1356861001947 substrate binding pocket [chemical binding]; other site 1356861001948 active site 1356861001949 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1356861001950 ferredoxin; Provisional; Region: PRK08764 1356861001951 Putative Fe-S cluster; Region: FeS; cl17515 1356861001952 4Fe-4S binding domain; Region: Fer4; pfam00037 1356861001953 glutaredoxin 2; Provisional; Region: PRK10387 1356861001954 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1356861001955 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1356861001956 N-terminal domain interface [polypeptide binding]; other site 1356861001957 POT family; Region: PTR2; cl17359 1356861001958 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 1356861001959 POT family; Region: PTR2; cl17359 1356861001960 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1356861001961 Ferritin-like domain; Region: Ferritin; pfam00210 1356861001962 ferroxidase diiron center [ion binding]; other site 1356861001963 lipoyl synthase; Provisional; Region: PRK05481 1356861001964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1356861001965 FeS/SAM binding site; other site 1356861001966 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1356861001967 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1356861001968 conserved cys residue [active] 1356861001969 hypothetical protein; Validated; Region: PRK00110 1356861001970 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1356861001971 active site 1356861001972 putative DNA-binding cleft [nucleotide binding]; other site 1356861001973 dimer interface [polypeptide binding]; other site 1356861001974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861001975 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1356861001976 putative substrate translocation pore; other site 1356861001977 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1356861001978 RuvA N terminal domain; Region: RuvA_N; pfam01330 1356861001979 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1356861001980 RmuC family; Region: RmuC; pfam02646 1356861001981 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1356861001982 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1356861001983 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1356861001984 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1356861001985 Zn binding site [ion binding]; other site 1356861001986 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1356861001987 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1356861001988 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1356861001989 active site 1356861001990 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1356861001991 5S rRNA interface [nucleotide binding]; other site 1356861001992 CTC domain interface [polypeptide binding]; other site 1356861001993 L16 interface [polypeptide binding]; other site 1356861001994 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1356861001995 Domain of unknown function DUF21; Region: DUF21; pfam01595 1356861001996 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1356861001997 Transporter associated domain; Region: CorC_HlyC; pfam03471 1356861001998 GTP-binding protein YchF; Reviewed; Region: PRK09601 1356861001999 YchF GTPase; Region: YchF; cd01900 1356861002000 G1 box; other site 1356861002001 GTP/Mg2+ binding site [chemical binding]; other site 1356861002002 Switch I region; other site 1356861002003 G2 box; other site 1356861002004 Switch II region; other site 1356861002005 G3 box; other site 1356861002006 G4 box; other site 1356861002007 G5 box; other site 1356861002008 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1356861002009 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1356861002010 putative active site [active] 1356861002011 catalytic residue [active] 1356861002012 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1356861002013 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1356861002014 dimerization domain [polypeptide binding]; other site 1356861002015 dimer interface [polypeptide binding]; other site 1356861002016 catalytic residues [active] 1356861002017 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1356861002018 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1356861002019 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1356861002020 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1356861002021 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1356861002022 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1356861002023 Ion transport protein; Region: Ion_trans; pfam00520 1356861002024 Ion channel; Region: Ion_trans_2; pfam07885 1356861002025 TrkA-N domain; Region: TrkA_N; pfam02254 1356861002026 POT family; Region: PTR2; cl17359 1356861002027 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 1356861002028 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1356861002029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1356861002030 Walker A motif; other site 1356861002031 ATP binding site [chemical binding]; other site 1356861002032 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1356861002033 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1356861002034 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1356861002035 active site 1356861002036 HslU subunit interaction site [polypeptide binding]; other site 1356861002037 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1356861002038 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1356861002039 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1356861002040 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1356861002041 active site 1356861002042 HIGH motif; other site 1356861002043 dimer interface [polypeptide binding]; other site 1356861002044 KMSKS motif; other site 1356861002045 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1356861002046 RNA binding surface [nucleotide binding]; other site 1356861002047 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1356861002048 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1356861002049 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1356861002050 putative active site [active] 1356861002051 putative catalytic site [active] 1356861002052 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1356861002053 RNA binding surface [nucleotide binding]; other site 1356861002054 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1356861002055 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1356861002056 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1356861002057 HlyD family secretion protein; Region: HlyD_3; pfam13437 1356861002058 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1356861002059 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1356861002060 Bacterial transcriptional regulator; Region: IclR; pfam01614 1356861002061 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1356861002062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1356861002063 FeS/SAM binding site; other site 1356861002064 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1356861002065 NAD binding site [chemical binding]; other site 1356861002066 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1356861002067 DNA-binding site [nucleotide binding]; DNA binding site 1356861002068 RNA-binding motif; other site 1356861002069 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1356861002070 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1356861002071 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1356861002072 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1356861002073 active site 1356861002074 tetramer interface; other site 1356861002075 acetyl-CoA synthetase; Provisional; Region: PRK00174 1356861002076 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1356861002077 active site 1356861002078 CoA binding site [chemical binding]; other site 1356861002079 acyl-activating enzyme (AAE) consensus motif; other site 1356861002080 AMP binding site [chemical binding]; other site 1356861002081 acetate binding site [chemical binding]; other site 1356861002082 EamA-like transporter family; Region: EamA; pfam00892 1356861002083 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1356861002084 EamA-like transporter family; Region: EamA; pfam00892 1356861002085 recombination protein F; Reviewed; Region: recF; PRK00064 1356861002086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1356861002087 Walker A/P-loop; other site 1356861002088 ATP binding site [chemical binding]; other site 1356861002089 Q-loop/lid; other site 1356861002090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1356861002091 ABC transporter signature motif; other site 1356861002092 Walker B; other site 1356861002093 D-loop; other site 1356861002094 H-loop/switch region; other site 1356861002095 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1356861002096 active site 1356861002097 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1356861002098 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1356861002099 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1356861002100 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1356861002101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861002102 putative substrate translocation pore; other site 1356861002103 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1356861002104 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1356861002105 active site 1356861002106 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1356861002107 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1356861002108 Ligand Binding Site [chemical binding]; other site 1356861002109 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1356861002110 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1356861002111 Ligand binding site; other site 1356861002112 oligomer interface; other site 1356861002113 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1356861002114 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1356861002115 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1356861002116 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1356861002117 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1356861002118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861002119 putative substrate translocation pore; other site 1356861002120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861002121 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1356861002122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861002123 putative substrate translocation pore; other site 1356861002124 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1356861002125 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1356861002126 helicase 45; Provisional; Region: PTZ00424 1356861002127 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1356861002128 ATP binding site [chemical binding]; other site 1356861002129 Mg++ binding site [ion binding]; other site 1356861002130 motif III; other site 1356861002131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1356861002132 nucleotide binding region [chemical binding]; other site 1356861002133 ATP-binding site [chemical binding]; other site 1356861002134 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1356861002135 putative RNA binding site [nucleotide binding]; other site 1356861002136 Guanylate kinase; Region: Guanylate_kin; pfam00625 1356861002137 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1356861002138 catalytic site [active] 1356861002139 G-X2-G-X-G-K; other site 1356861002140 quinolinate synthetase; Provisional; Region: PRK09375 1356861002141 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1356861002142 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1356861002143 dimerization interface [polypeptide binding]; other site 1356861002144 active site 1356861002145 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1356861002146 L-aspartate oxidase; Provisional; Region: PRK06175 1356861002147 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1356861002148 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1356861002149 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1356861002150 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1356861002151 cytidylate kinase; Provisional; Region: cmk; PRK00023 1356861002152 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1356861002153 CMP-binding site; other site 1356861002154 The sites determining sugar specificity; other site 1356861002155 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1356861002156 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1356861002157 catalytic residue [active] 1356861002158 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1356861002159 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1356861002160 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1356861002161 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1356861002162 active site residue [active] 1356861002163 Cyclic phosphodiesterase-like protein; Region: CPDase; pfam07823 1356861002164 Putative exonuclease, RdgC; Region: RdgC; cl01122 1356861002165 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1356861002166 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1356861002167 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1356861002168 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 1356861002169 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1356861002170 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1356861002171 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1356861002172 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1356861002173 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1356861002174 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1356861002175 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1356861002176 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1356861002177 Palmitoyl protein thioesterase; Region: Palm_thioest; cl15849 1356861002178 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1356861002179 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1356861002180 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1356861002181 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1356861002182 acyl-activating enzyme (AAE) consensus motif; other site 1356861002183 AMP binding site [chemical binding]; other site 1356861002184 Condensation domain; Region: Condensation; pfam00668 1356861002185 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1356861002186 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1356861002187 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1356861002188 acyl-activating enzyme (AAE) consensus motif; other site 1356861002189 AMP binding site [chemical binding]; other site 1356861002190 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1356861002191 dimer interface [polypeptide binding]; other site 1356861002192 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1356861002193 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1356861002194 Condensation domain; Region: Condensation; pfam00668 1356861002195 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1356861002196 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1356861002197 acyl-activating enzyme (AAE) consensus motif; other site 1356861002198 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1356861002199 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1356861002200 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1356861002201 AMP binding site [chemical binding]; other site 1356861002202 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1356861002203 Condensation domain; Region: Condensation; pfam00668 1356861002204 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1356861002205 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1356861002206 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1356861002207 acyl-activating enzyme (AAE) consensus motif; other site 1356861002208 AMP binding site [chemical binding]; other site 1356861002209 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1356861002210 Condensation domain; Region: Condensation; pfam00668 1356861002211 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1356861002212 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1356861002213 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1356861002214 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1356861002215 acyl-activating enzyme (AAE) consensus motif; other site 1356861002216 AMP binding site [chemical binding]; other site 1356861002217 active site 1356861002218 CoA binding site [chemical binding]; other site 1356861002219 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1356861002220 Condensation domain; Region: Condensation; pfam00668 1356861002221 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1356861002222 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1356861002223 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1356861002224 acyl-activating enzyme (AAE) consensus motif; other site 1356861002225 AMP binding site [chemical binding]; other site 1356861002226 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1356861002227 Condensation domain; Region: Condensation; pfam00668 1356861002228 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1356861002229 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1356861002230 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1356861002231 acyl-activating enzyme (AAE) consensus motif; other site 1356861002232 AMP binding site [chemical binding]; other site 1356861002233 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1356861002234 FMN binding site [chemical binding]; other site 1356861002235 dimer interface [polypeptide binding]; other site 1356861002236 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1356861002237 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1356861002238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1356861002239 hypothetical protein; Provisional; Region: PRK07206 1356861002240 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1356861002241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861002242 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1356861002243 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1356861002244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1356861002245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1356861002246 S-adenosylmethionine binding site [chemical binding]; other site 1356861002247 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1356861002248 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1356861002249 ArsC family; Region: ArsC; pfam03960 1356861002250 catalytic residues [active] 1356861002251 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1356861002252 dimerization interface [polypeptide binding]; other site 1356861002253 putative DNA binding site [nucleotide binding]; other site 1356861002254 putative Zn2+ binding site [ion binding]; other site 1356861002255 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1356861002256 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1356861002257 putative active site [active] 1356861002258 substrate binding site [chemical binding]; other site 1356861002259 putative cosubstrate binding site; other site 1356861002260 catalytic site [active] 1356861002261 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1356861002262 substrate binding site [chemical binding]; other site 1356861002263 glutathione synthetase; Provisional; Region: PRK05246 1356861002264 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1356861002265 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1356861002266 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1356861002267 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1356861002268 inhibitor-cofactor binding pocket; inhibition site 1356861002269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861002270 catalytic residue [active] 1356861002271 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1356861002272 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1356861002273 heme-binding site [chemical binding]; other site 1356861002274 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1356861002275 FAD binding pocket [chemical binding]; other site 1356861002276 FAD binding motif [chemical binding]; other site 1356861002277 phosphate binding motif [ion binding]; other site 1356861002278 beta-alpha-beta structure motif; other site 1356861002279 NAD binding pocket [chemical binding]; other site 1356861002280 Heme binding pocket [chemical binding]; other site 1356861002281 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1356861002282 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1356861002283 L-fucose transporter; Provisional; Region: PRK10133; cl17665 1356861002284 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1356861002285 L-fucose transporter; Provisional; Region: PRK10133; cl17665 1356861002286 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1356861002287 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1356861002288 nucleotide binding site [chemical binding]; other site 1356861002289 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1356861002290 dimerization interface [polypeptide binding]; other site 1356861002291 putative DNA binding site [nucleotide binding]; other site 1356861002292 putative Zn2+ binding site [ion binding]; other site 1356861002293 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1356861002294 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1356861002295 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1356861002296 catalytic residue [active] 1356861002297 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1356861002298 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1356861002299 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1356861002300 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); Region: HPPK; pfam01288 1356861002301 catalytic center binding site [active] 1356861002302 ATP binding site [chemical binding]; other site 1356861002303 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1356861002304 dihydropteroate synthase; Region: DHPS; TIGR01496 1356861002305 substrate binding pocket [chemical binding]; other site 1356861002306 dimer interface [polypeptide binding]; other site 1356861002307 inhibitor binding site; inhibition site 1356861002308 Dihydroneopterin aldolase; Region: FolB; smart00905 1356861002309 active site 1356861002310 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1356861002311 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1356861002312 glutamine binding [chemical binding]; other site 1356861002313 catalytic triad [active] 1356861002314 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1356861002315 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1356861002316 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1356861002317 catalytic tetrad [active] 1356861002318 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1356861002319 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1356861002320 active site 1356861002321 catalytic triad [active] 1356861002322 dimer interface [polypeptide binding]; other site 1356861002323 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1356861002324 active site 1356861002325 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1356861002326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861002327 putative substrate translocation pore; other site 1356861002328 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1356861002329 glutathione reductase; Validated; Region: PRK06116 1356861002330 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1356861002331 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1356861002332 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1356861002333 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1356861002334 putative active site [active] 1356861002335 putative catalytic site [active] 1356861002336 putative DNA binding site [nucleotide binding]; other site 1356861002337 putative phosphate binding site [ion binding]; other site 1356861002338 metal binding site A [ion binding]; metal-binding site 1356861002339 putative AP binding site [nucleotide binding]; other site 1356861002340 putative metal binding site B [ion binding]; other site 1356861002341 Bor protein; Region: Lambda_Bor; pfam06291 1356861002342 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1356861002343 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1356861002344 signal recognition particle protein; Provisional; Region: PRK10867 1356861002345 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1356861002346 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1356861002347 P loop; other site 1356861002348 GTP binding site [chemical binding]; other site 1356861002349 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1356861002350 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1356861002351 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1356861002352 rRNA binding site [nucleotide binding]; other site 1356861002353 predicted 30S ribosome binding site; other site 1356861002354 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1356861002355 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1356861002356 TrkA-N domain; Region: TrkA_N; pfam02254 1356861002357 TrkA-C domain; Region: TrkA_C; pfam02080 1356861002358 TrkA-N domain; Region: TrkA_N; pfam02254 1356861002359 TrkA-C domain; Region: TrkA_C; pfam02080 1356861002360 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1356861002361 Transcriptional regulator; Region: Rrf2; pfam02082 1356861002362 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1356861002363 putative ABC transporter; Region: ycf24; CHL00085 1356861002364 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1356861002365 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1356861002366 Walker A/P-loop; other site 1356861002367 ATP binding site [chemical binding]; other site 1356861002368 Q-loop/lid; other site 1356861002369 ABC transporter signature motif; other site 1356861002370 Walker B; other site 1356861002371 D-loop; other site 1356861002372 H-loop/switch region; other site 1356861002373 FeS assembly protein SufD; Region: sufD; TIGR01981 1356861002374 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1356861002375 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1356861002376 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1356861002377 catalytic residues [active] 1356861002378 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1356861002379 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1356861002380 active site 1356861002381 8-oxo-dGMP binding site [chemical binding]; other site 1356861002382 nudix motif; other site 1356861002383 metal binding site [ion binding]; metal-binding site 1356861002384 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 1356861002385 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1356861002386 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1356861002387 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1356861002388 HIGH motif; other site 1356861002389 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1356861002390 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1356861002391 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1356861002392 active site 1356861002393 KMSKS motif; other site 1356861002394 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1356861002395 tRNA binding surface [nucleotide binding]; other site 1356861002396 Lipopolysaccharide-assembly; Region: LptE; cl01125 1356861002397 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1356861002398 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1356861002399 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1356861002400 trimer interface [polypeptide binding]; other site 1356861002401 active site 1356861002402 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 1356861002403 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1356861002404 Walker A motif; other site 1356861002405 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1356861002406 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 1356861002407 putative active site [active] 1356861002408 catalytic site [active] 1356861002409 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 1356861002410 putative active site [active] 1356861002411 catalytic site [active] 1356861002412 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 1356861002413 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1356861002414 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1356861002415 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1356861002416 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1356861002417 putative tRNA-binding site [nucleotide binding]; other site 1356861002418 B3/4 domain; Region: B3_4; pfam03483 1356861002419 tRNA synthetase B5 domain; Region: B5; smart00874 1356861002420 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1356861002421 dimer interface [polypeptide binding]; other site 1356861002422 motif 1; other site 1356861002423 motif 3; other site 1356861002424 motif 2; other site 1356861002425 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1356861002426 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1356861002427 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1356861002428 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1356861002429 dimer interface [polypeptide binding]; other site 1356861002430 motif 1; other site 1356861002431 active site 1356861002432 motif 2; other site 1356861002433 motif 3; other site 1356861002434 POT family; Region: PTR2; cl17359 1356861002435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1356861002436 non-specific DNA binding site [nucleotide binding]; other site 1356861002437 salt bridge; other site 1356861002438 sequence-specific DNA binding site [nucleotide binding]; other site 1356861002439 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1356861002440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1356861002441 Walker A motif; other site 1356861002442 ATP binding site [chemical binding]; other site 1356861002443 Walker B motif; other site 1356861002444 arginine finger; other site 1356861002445 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1356861002446 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1356861002447 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1356861002448 active site 1356861002449 catalytic triad [active] 1356861002450 oxyanion hole [active] 1356861002451 switch loop; other site 1356861002452 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1356861002453 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1356861002454 TPP-binding site; other site 1356861002455 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1356861002456 PYR/PP interface [polypeptide binding]; other site 1356861002457 dimer interface [polypeptide binding]; other site 1356861002458 TPP binding site [chemical binding]; other site 1356861002459 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1356861002460 GMP synthase; Reviewed; Region: guaA; PRK00074 1356861002461 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1356861002462 AMP/PPi binding site [chemical binding]; other site 1356861002463 candidate oxyanion hole; other site 1356861002464 catalytic triad [active] 1356861002465 potential glutamine specificity residues [chemical binding]; other site 1356861002466 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1356861002467 ATP Binding subdomain [chemical binding]; other site 1356861002468 Ligand Binding sites [chemical binding]; other site 1356861002469 Dimerization subdomain; other site 1356861002470 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1356861002471 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1356861002472 dimerization interface 3.5A [polypeptide binding]; other site 1356861002473 active site 1356861002474 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1356861002475 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1356861002476 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1356861002477 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1356861002478 Walker A/P-loop; other site 1356861002479 ATP binding site [chemical binding]; other site 1356861002480 Q-loop/lid; other site 1356861002481 ABC transporter signature motif; other site 1356861002482 Walker B; other site 1356861002483 D-loop; other site 1356861002484 H-loop/switch region; other site 1356861002485 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1356861002486 OstA-like protein; Region: OstA; cl00844 1356861002487 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1356861002488 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1356861002489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1356861002490 active site 1356861002491 motif I; other site 1356861002492 motif II; other site 1356861002493 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1356861002494 dimer interface [polypeptide binding]; other site 1356861002495 substrate binding site [chemical binding]; other site 1356861002496 metal binding sites [ion binding]; metal-binding site 1356861002497 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1356861002498 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1356861002499 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1356861002500 Protein of unknown function (DUF493); Region: DUF493; pfam04359 1356861002501 lipoate-protein ligase B; Provisional; Region: PRK14342 1356861002502 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1356861002503 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1356861002504 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1356861002505 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1356861002506 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1356861002507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1356861002508 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1356861002509 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1356861002510 DNA binding residues [nucleotide binding] 1356861002511 DNA primase; Validated; Region: dnaG; PRK05667 1356861002512 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1356861002513 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1356861002514 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1356861002515 active site 1356861002516 metal binding site [ion binding]; metal-binding site 1356861002517 interdomain interaction site; other site 1356861002518 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1356861002519 Yqey-like protein; Region: YqeY; pfam09424 1356861002520 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1356861002521 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1356861002522 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1356861002523 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1356861002524 Ligand Binding Site [chemical binding]; other site 1356861002525 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1356861002526 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1356861002527 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1356861002528 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1356861002529 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1356861002530 substrate binding pocket [chemical binding]; other site 1356861002531 chain length determination region; other site 1356861002532 substrate-Mg2+ binding site; other site 1356861002533 catalytic residues [active] 1356861002534 aspartate-rich region 1; other site 1356861002535 active site lid residues [active] 1356861002536 aspartate-rich region 2; other site 1356861002537 PQ loop repeat; Region: PQ-loop; cl17546 1356861002538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1356861002539 Coenzyme A binding pocket [chemical binding]; other site 1356861002540 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1356861002541 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1356861002542 RNA binding surface [nucleotide binding]; other site 1356861002543 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1356861002544 active site 1356861002545 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1356861002546 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1356861002547 FeS/SAM binding site; other site 1356861002548 replicative DNA helicase; Region: DnaB; TIGR00665 1356861002549 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1356861002550 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1356861002551 Walker A motif; other site 1356861002552 ATP binding site [chemical binding]; other site 1356861002553 Walker B motif; other site 1356861002554 DNA binding loops [nucleotide binding] 1356861002555 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1356861002556 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1356861002557 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1356861002558 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1356861002559 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1356861002560 S1 domain; Region: S1_2; pfam13509 1356861002561 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1356861002562 S1 domain; Region: S1_2; pfam13509 1356861002563 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1356861002564 Part of AAA domain; Region: AAA_19; pfam13245 1356861002565 Family description; Region: UvrD_C_2; pfam13538 1356861002566 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1356861002567 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1356861002568 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1356861002569 transaldolase-like protein; Provisional; Region: PTZ00411 1356861002570 active site 1356861002571 dimer interface [polypeptide binding]; other site 1356861002572 catalytic residue [active] 1356861002573 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1356861002574 interface (dimer of trimers) [polypeptide binding]; other site 1356861002575 Substrate-binding/catalytic site; other site 1356861002576 Zn-binding sites [ion binding]; other site 1356861002577 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1356861002578 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1356861002579 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1356861002580 motif 1; other site 1356861002581 active site 1356861002582 motif 2; other site 1356861002583 motif 3; other site 1356861002584 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1356861002585 DHHA1 domain; Region: DHHA1; pfam02272 1356861002586 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1356861002587 Part of AAA domain; Region: AAA_19; pfam13245 1356861002588 Family description; Region: UvrD_C_2; pfam13538 1356861002589 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1356861002590 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1356861002591 epoxyqueuosine reductase; Region: TIGR00276 1356861002592 epoxyqueuosine reductase; Region: TIGR00276 1356861002593 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1356861002594 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1356861002595 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1356861002596 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1356861002597 catalytic residues [active] 1356861002598 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 1356861002599 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1356861002600 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 1356861002601 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1356861002602 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1356861002603 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1356861002604 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1356861002605 active site 1356861002606 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1356861002607 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1356861002608 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1356861002609 substrate binding pocket [chemical binding]; other site 1356861002610 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1356861002611 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1356861002612 metal binding site [ion binding]; metal-binding site 1356861002613 Protein of unknown function (DUF819); Region: DUF819; cl02317 1356861002614 Protein of unknown function (DUF819); Region: DUF819; cl02317 1356861002615 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1356861002616 catalytic residues [active] 1356861002617 dimer interface [polypeptide binding]; other site 1356861002618 Chorismate mutase type II; Region: CM_2; smart00830 1356861002619 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1356861002620 catalytic triad [active] 1356861002621 dimer interface [polypeptide binding]; other site 1356861002622 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1356861002623 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1356861002624 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1356861002625 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1356861002626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 1356861002627 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1356861002628 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1356861002629 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1356861002630 active site 1356861002631 catalytic site [active] 1356861002632 substrate binding site [chemical binding]; other site 1356861002633 peroxidase; Provisional; Region: PRK15000 1356861002634 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1356861002635 dimer interface [polypeptide binding]; other site 1356861002636 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1356861002637 catalytic triad [active] 1356861002638 peroxidatic and resolving cysteines [active] 1356861002639 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1356861002640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1356861002641 motif II; other site 1356861002642 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1356861002643 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1356861002644 putative ATP binding site [chemical binding]; other site 1356861002645 putative substrate interface [chemical binding]; other site 1356861002646 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1356861002647 catalytic residue [active] 1356861002648 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1356861002649 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1356861002650 diiron binding motif [ion binding]; other site 1356861002651 malate dehydrogenase; Reviewed; Region: PRK06223 1356861002652 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1356861002653 NAD(P) binding site [chemical binding]; other site 1356861002654 dimer interface [polypeptide binding]; other site 1356861002655 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1356861002656 substrate binding site [chemical binding]; other site 1356861002657 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 1356861002658 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1356861002659 active site 1356861002660 dimer interface [polypeptide binding]; other site 1356861002661 catalytic residues [active] 1356861002662 effector binding site; other site 1356861002663 R2 peptide binding site; other site 1356861002664 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 1356861002665 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1356861002666 GSH binding site [chemical binding]; other site 1356861002667 catalytic residues [active] 1356861002668 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1356861002669 dimer interface [polypeptide binding]; other site 1356861002670 putative radical transfer pathway; other site 1356861002671 diiron center [ion binding]; other site 1356861002672 tyrosyl radical; other site 1356861002673 Beta-lactamase; Region: Beta-lactamase; cl17358 1356861002674 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1356861002675 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1356861002676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861002677 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1356861002678 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1356861002679 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1356861002680 ABC transporter; Region: ABC_tran_2; pfam12848 1356861002681 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1356861002682 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1356861002683 active site 1356861002684 DNA polymerase IV; Validated; Region: PRK02406 1356861002685 DNA binding site [nucleotide binding] 1356861002686 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1356861002687 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1356861002688 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1356861002689 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1356861002690 FMN binding site [chemical binding]; other site 1356861002691 active site 1356861002692 catalytic residues [active] 1356861002693 substrate binding site [chemical binding]; other site 1356861002694 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1356861002695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1356861002696 S-adenosylmethionine binding site [chemical binding]; other site 1356861002697 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1356861002698 ferrochelatase; Reviewed; Region: hemH; PRK00035 1356861002699 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1356861002700 C-terminal domain interface [polypeptide binding]; other site 1356861002701 active site 1356861002702 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1356861002703 active site 1356861002704 N-terminal domain interface [polypeptide binding]; other site 1356861002705 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1356861002706 DNA photolyase; Region: DNA_photolyase; pfam00875 1356861002707 enolase; Provisional; Region: eno; PRK00077 1356861002708 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1356861002709 dimer interface [polypeptide binding]; other site 1356861002710 metal binding site [ion binding]; metal-binding site 1356861002711 substrate binding pocket [chemical binding]; other site 1356861002712 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1356861002713 Flavoprotein; Region: Flavoprotein; pfam02441 1356861002714 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1356861002715 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 1356861002716 Proline dehydrogenase; Region: Pro_dh; pfam01619 1356861002717 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1356861002718 Glutamate binding site [chemical binding]; other site 1356861002719 NAD binding site [chemical binding]; other site 1356861002720 catalytic residues [active] 1356861002721 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1356861002722 NAD(P) binding site [chemical binding]; other site 1356861002723 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1356861002724 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 1356861002725 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1356861002726 active site 1356861002727 dimer interface [polypeptide binding]; other site 1356861002728 metal binding site [ion binding]; metal-binding site 1356861002729 shikimate kinase; Reviewed; Region: aroK; PRK00131 1356861002730 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1356861002731 ADP binding site [chemical binding]; other site 1356861002732 magnesium binding site [ion binding]; other site 1356861002733 putative shikimate binding site; other site 1356861002734 adenylate kinase; Reviewed; Region: adk; PRK00279 1356861002735 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1356861002736 AMP-binding site [chemical binding]; other site 1356861002737 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1356861002738 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1356861002739 FAD binding domain; Region: FAD_binding_4; pfam01565 1356861002740 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1356861002741 Cysteine-rich domain; Region: CCG; pfam02754 1356861002742 GTPase Era; Reviewed; Region: era; PRK00089 1356861002743 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1356861002744 G1 box; other site 1356861002745 GTP/Mg2+ binding site [chemical binding]; other site 1356861002746 Switch I region; other site 1356861002747 G2 box; other site 1356861002748 Switch II region; other site 1356861002749 G3 box; other site 1356861002750 G4 box; other site 1356861002751 G5 box; other site 1356861002752 aspartate aminotransferase; Provisional; Region: PRK05764 1356861002753 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1356861002754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861002755 homodimer interface [polypeptide binding]; other site 1356861002756 catalytic residue [active] 1356861002757 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1356861002758 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1356861002759 putative active site [active] 1356861002760 putative dimer interface [polypeptide binding]; other site 1356861002761 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1356861002762 Glycoprotease family; Region: Peptidase_M22; pfam00814 1356861002763 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1356861002764 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1356861002765 active site 1356861002766 dimer interface [polypeptide binding]; other site 1356861002767 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1356861002768 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1356861002769 GTP/Mg2+ binding site [chemical binding]; other site 1356861002770 G4 box; other site 1356861002771 G5 box; other site 1356861002772 G1 box; other site 1356861002773 Switch I region; other site 1356861002774 G2 box; other site 1356861002775 G3 box; other site 1356861002776 Switch II region; other site 1356861002777 thymidine kinase; Provisional; Region: PRK04296 1356861002778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1356861002779 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1356861002780 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1356861002781 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1356861002782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1356861002783 FeS/SAM binding site; other site 1356861002784 TRAM domain; Region: TRAM; pfam01938 1356861002785 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1356861002786 PhoH-like protein; Region: PhoH; pfam02562 1356861002787 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1356861002788 dimer interface [polypeptide binding]; other site 1356861002789 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1356861002790 metal binding site [ion binding]; metal-binding site 1356861002791 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1356861002792 Transporter associated domain; Region: CorC_HlyC; smart01091 1356861002793 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1356861002794 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1356861002795 putative active site [active] 1356861002796 catalytic triad [active] 1356861002797 putative dimer interface [polypeptide binding]; other site 1356861002798 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1356861002799 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1356861002800 active site 1356861002801 substrate binding site [chemical binding]; other site 1356861002802 Mg2+ binding site [ion binding]; other site 1356861002803 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1356861002804 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1356861002805 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1356861002806 active site 1356861002807 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1356861002808 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1356861002809 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1356861002810 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1356861002811 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1356861002812 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1356861002813 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1356861002814 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1356861002815 active site 1356861002816 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1356861002817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861002818 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1356861002819 putative substrate translocation pore; other site 1356861002820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861002821 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1356861002822 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1356861002823 dimer interface [polypeptide binding]; other site 1356861002824 active site 1356861002825 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1356861002826 dimer interface [polypeptide binding]; other site 1356861002827 active site 1356861002828 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1356861002829 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1356861002830 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1356861002831 hypothetical protein; Validated; Region: PRK00029 1356861002832 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1356861002833 Rubredoxin; Region: Rubredoxin; pfam00301 1356861002834 iron binding site [ion binding]; other site 1356861002835 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1356861002836 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1356861002837 G1 box; other site 1356861002838 putative GEF interaction site [polypeptide binding]; other site 1356861002839 GTP/Mg2+ binding site [chemical binding]; other site 1356861002840 Switch I region; other site 1356861002841 G2 box; other site 1356861002842 G3 box; other site 1356861002843 Switch II region; other site 1356861002844 G4 box; other site 1356861002845 G5 box; other site 1356861002846 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1356861002847 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1356861002848 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1356861002849 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1356861002850 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1356861002851 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 1356861002852 hypothetical protein; Validated; Region: PRK01777 1356861002853 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1356861002854 putative coenzyme Q binding site [chemical binding]; other site 1356861002855 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1356861002856 SmpB-tmRNA interface; other site 1356861002857 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1356861002858 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1356861002859 catalytic residue [active] 1356861002860 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1356861002861 phosphate binding site [ion binding]; other site 1356861002862 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1356861002863 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1356861002864 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1356861002865 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1356861002866 generic binding surface II; other site 1356861002867 generic binding surface I; other site 1356861002868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861002869 metabolite-proton symporter; Region: 2A0106; TIGR00883 1356861002870 putative substrate translocation pore; other site 1356861002871 glutamate racemase; Provisional; Region: PRK00865 1356861002872 Nuclease-related domain; Region: NERD; pfam08378 1356861002873 excinuclease ABC subunit B; Provisional; Region: PRK05298 1356861002874 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1356861002875 ATP binding site [chemical binding]; other site 1356861002876 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1356861002877 nucleotide binding region [chemical binding]; other site 1356861002878 ATP-binding site [chemical binding]; other site 1356861002879 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1356861002880 UvrB/uvrC motif; Region: UVR; pfam02151 1356861002881 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1356861002882 active site 1356861002883 catalytic site [active] 1356861002884 substrate binding site [chemical binding]; other site 1356861002885 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1356861002886 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1356861002887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1356861002888 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1356861002889 putative effector binding pocket; other site 1356861002890 dimerization interface [polypeptide binding]; other site 1356861002891 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1356861002892 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1356861002893 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1356861002894 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1356861002895 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1356861002896 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1356861002897 active site 1356861002898 dimer interface [polypeptide binding]; other site 1356861002899 Pirin-related protein [General function prediction only]; Region: COG1741 1356861002900 Pirin; Region: Pirin; pfam02678 1356861002901 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1356861002902 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1356861002903 catalytic residue [active] 1356861002904 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1356861002905 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1356861002906 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1356861002907 23S rRNA binding site [nucleotide binding]; other site 1356861002908 L21 binding site [polypeptide binding]; other site 1356861002909 L13 binding site [polypeptide binding]; other site 1356861002910 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1356861002911 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1356861002912 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1356861002913 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1356861002914 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1356861002915 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1356861002916 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1356861002917 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1356861002918 active site 1356861002919 dimer interface [polypeptide binding]; other site 1356861002920 motif 1; other site 1356861002921 motif 2; other site 1356861002922 motif 3; other site 1356861002923 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1356861002924 anticodon binding site; other site 1356861002925 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1356861002926 lipoyl attachment site [posttranslational modification]; other site 1356861002927 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1356861002928 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1356861002929 homodimer interface [polypeptide binding]; other site 1356861002930 active site 1356861002931 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1356861002932 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1356861002933 Zn2+ binding site [ion binding]; other site 1356861002934 Mg2+ binding site [ion binding]; other site 1356861002935 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1356861002936 synthetase active site [active] 1356861002937 NTP binding site [chemical binding]; other site 1356861002938 metal binding site [ion binding]; metal-binding site 1356861002939 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1356861002940 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1356861002941 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 1356861002942 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1356861002943 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1356861002944 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1356861002945 Fungal protease inhibitor; Region: amfpi-1; pfam12190 1356861002946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861002947 metabolite-proton symporter; Region: 2A0106; TIGR00883 1356861002948 putative substrate translocation pore; other site 1356861002949 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1356861002950 proposed catalytic triad [active] 1356861002951 active site nucleophile [active] 1356861002952 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1356861002953 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1356861002954 substrate binding site [chemical binding]; other site 1356861002955 ATP binding site [chemical binding]; other site 1356861002956 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 1356861002957 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1356861002958 motif II; other site 1356861002959 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1356861002960 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1356861002961 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1356861002962 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1356861002963 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1356861002964 metal-binding site 1356861002965 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1356861002966 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1356861002967 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1356861002968 extended (e) SDRs; Region: SDR_e; cd08946 1356861002969 NAD(P) binding site [chemical binding]; other site 1356861002970 active site 1356861002971 substrate binding site [chemical binding]; other site 1356861002972 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1356861002973 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1356861002974 pseudaminic acid synthase; Region: PseI; TIGR03586 1356861002975 NeuB family; Region: NeuB; pfam03102 1356861002976 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1356861002977 NeuB binding interface [polypeptide binding]; other site 1356861002978 putative substrate binding site [chemical binding]; other site 1356861002979 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1356861002980 ligand binding site; other site 1356861002981 tetramer interface; other site 1356861002982 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1356861002983 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1356861002984 inhibitor-cofactor binding pocket; inhibition site 1356861002985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861002986 catalytic residue [active] 1356861002987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1356861002988 NAD(P) binding site [chemical binding]; other site 1356861002989 active site 1356861002990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1356861002991 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1356861002992 putative ADP-binding pocket [chemical binding]; other site 1356861002993 UDP-glucose 4-epimerase; Region: PLN02240 1356861002994 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1356861002995 NAD binding site [chemical binding]; other site 1356861002996 homodimer interface [polypeptide binding]; other site 1356861002997 active site 1356861002998 substrate binding site [chemical binding]; other site 1356861002999 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1356861003000 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1356861003001 substrate binding site [chemical binding]; other site 1356861003002 hexamer interface [polypeptide binding]; other site 1356861003003 metal binding site [ion binding]; metal-binding site 1356861003004 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1356861003005 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1356861003006 putative active site [active] 1356861003007 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1356861003008 hypothetical protein; Provisional; Region: PRK05409 1356861003009 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1356861003010 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1356861003011 NAD binding site [chemical binding]; other site 1356861003012 homotetramer interface [polypeptide binding]; other site 1356861003013 homodimer interface [polypeptide binding]; other site 1356861003014 substrate binding site [chemical binding]; other site 1356861003015 active site 1356861003016 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1356861003017 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1356861003018 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1356861003019 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1356861003020 dimer interface [polypeptide binding]; other site 1356861003021 active site 1356861003022 metal binding site [ion binding]; metal-binding site 1356861003023 glutathione binding site [chemical binding]; other site 1356861003024 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1356861003025 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1356861003026 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1356861003027 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1356861003028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1356861003029 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1356861003030 ATP binding site [chemical binding]; other site 1356861003031 putative Mg++ binding site [ion binding]; other site 1356861003032 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1356861003033 nucleotide binding region [chemical binding]; other site 1356861003034 ATP-binding site [chemical binding]; other site 1356861003035 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1356861003036 active site 1356861003037 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1356861003038 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1356861003039 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1356861003040 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1356861003041 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1356861003042 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1356861003043 BolA-like protein; Region: BolA; cl00386 1356861003044 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1356861003045 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1356861003046 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1356861003047 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1356861003048 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1356861003049 Recombination protein O N terminal; Region: RecO_N; pfam11967 1356861003050 Recombination protein O C terminal; Region: RecO_C; pfam02565 1356861003051 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1356861003052 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1356861003053 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1356861003054 catalytic residue [active] 1356861003055 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1356861003056 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1356861003057 homodimer interface [polypeptide binding]; other site 1356861003058 oligonucleotide binding site [chemical binding]; other site 1356861003059 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1356861003060 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1356861003061 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1356861003062 dimerization interface [polypeptide binding]; other site 1356861003063 active site 1356861003064 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1356861003065 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1356861003066 ligand binding site [chemical binding]; other site 1356861003067 NAD binding site [chemical binding]; other site 1356861003068 tetramer interface [polypeptide binding]; other site 1356861003069 catalytic site [active] 1356861003070 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1356861003071 L-serine binding site [chemical binding]; other site 1356861003072 ACT domain interface; other site 1356861003073 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1356861003074 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1356861003075 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1356861003076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861003077 putative substrate translocation pore; other site 1356861003078 POT family; Region: PTR2; cl17359 1356861003079 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1356861003080 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1356861003081 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1356861003082 hypothetical protein; Provisional; Region: PRK05255 1356861003083 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1356861003084 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1356861003085 dimer interface [polypeptide binding]; other site 1356861003086 active site 1356861003087 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1356861003088 folate binding site [chemical binding]; other site 1356861003089 Berberine and berberine like; Region: BBE; pfam08031 1356861003090 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1356861003091 FAD binding domain; Region: FAD_binding_4; pfam01565 1356861003092 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1356861003093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1356861003094 TPR motif; other site 1356861003095 binding surface 1356861003096 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1356861003097 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1356861003098 RNA binding surface [nucleotide binding]; other site 1356861003099 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1356861003100 active site 1356861003101 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1356861003102 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1356861003103 Permease; Region: Permease; pfam02405 1356861003104 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1356861003105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1356861003106 Walker A/P-loop; other site 1356861003107 ATP binding site [chemical binding]; other site 1356861003108 Q-loop/lid; other site 1356861003109 ABC transporter signature motif; other site 1356861003110 Walker B; other site 1356861003111 D-loop; other site 1356861003112 H-loop/switch region; other site 1356861003113 mce related protein; Region: MCE; pfam02470 1356861003114 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1356861003115 RNA methyltransferase, RsmE family; Region: TIGR00046 1356861003116 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1356861003117 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1356861003118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861003119 putative substrate translocation pore; other site 1356861003120 POT family; Region: PTR2; cl17359 1356861003121 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1356861003122 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1356861003123 acyl-activating enzyme (AAE) consensus motif; other site 1356861003124 putative active site [active] 1356861003125 putative AMP binding site [chemical binding]; other site 1356861003126 putative CoA binding site [chemical binding]; other site 1356861003127 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1356861003128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861003129 putative substrate translocation pore; other site 1356861003130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861003131 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1356861003132 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1356861003133 HlyD family secretion protein; Region: HlyD_3; pfam13437 1356861003134 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1356861003135 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1356861003136 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1356861003137 homodimer interface [polypeptide binding]; other site 1356861003138 NAD binding pocket [chemical binding]; other site 1356861003139 ATP binding pocket [chemical binding]; other site 1356861003140 Mg binding site [ion binding]; other site 1356861003141 active-site loop [active] 1356861003142 chaperone protein DnaJ; Provisional; Region: PRK10767 1356861003143 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1356861003144 HSP70 interaction site [polypeptide binding]; other site 1356861003145 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1356861003146 substrate binding site [polypeptide binding]; other site 1356861003147 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1356861003148 Zn binding sites [ion binding]; other site 1356861003149 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1356861003150 dimer interface [polypeptide binding]; other site 1356861003151 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1356861003152 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1356861003153 nucleotide binding site [chemical binding]; other site 1356861003154 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1356861003155 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1356861003156 dimer interface [polypeptide binding]; other site 1356861003157 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1356861003158 MltA specific insert domain; Region: MltA; smart00925 1356861003159 3D domain; Region: 3D; pfam06725 1356861003160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1356861003161 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 1356861003162 Predicted ATPase [General function prediction only]; Region: COG4637 1356861003163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1356861003164 ABC transporter signature motif; other site 1356861003165 Walker B; other site 1356861003166 D-loop; other site 1356861003167 H-loop/switch region; other site 1356861003168 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1356861003169 23S rRNA interface [nucleotide binding]; other site 1356861003170 L3 interface [polypeptide binding]; other site 1356861003171 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1356861003172 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1356861003173 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1356861003174 MarR family; Region: MarR_2; pfam12802 1356861003175 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1356861003176 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1356861003177 Na binding site [ion binding]; other site 1356861003178 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1356861003179 RNA/DNA hybrid binding site [nucleotide binding]; other site 1356861003180 active site 1356861003181 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1356861003182 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1356861003183 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1356861003184 active site 1356861003185 phosphorylation site [posttranslational modification] 1356861003186 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1356861003187 30S subunit binding site; other site 1356861003188 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1356861003189 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1356861003190 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1356861003191 G1 box; other site 1356861003192 GTP/Mg2+ binding site [chemical binding]; other site 1356861003193 Switch I region; other site 1356861003194 G2 box; other site 1356861003195 Switch II region; other site 1356861003196 G3 box; other site 1356861003197 G4 box; other site 1356861003198 G5 box; other site 1356861003199 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1356861003200 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1356861003201 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1356861003202 putative Zn2+ binding site [ion binding]; other site 1356861003203 putative DNA binding site [nucleotide binding]; other site 1356861003204 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1356861003205 dimerization interface [polypeptide binding]; other site 1356861003206 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1356861003207 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1356861003208 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1356861003209 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1356861003210 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1356861003211 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1356861003212 dimer interface [polypeptide binding]; other site 1356861003213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861003214 catalytic residue [active] 1356861003215 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1356861003216 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1356861003217 Intracellular growth locus C protein; Region: IglC; pfam11550 1356861003218 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1356861003219 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1356861003220 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 1356861003221 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1356861003222 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1356861003223 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1356861003224 intersubunit interface [polypeptide binding]; other site 1356861003225 active site 1356861003226 zinc binding site [ion binding]; other site 1356861003227 Na+ binding site [ion binding]; other site 1356861003228 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1356861003229 pyruvate kinase; Provisional; Region: PRK05826 1356861003230 domain interfaces; other site 1356861003231 active site 1356861003232 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1356861003233 Phosphoglycerate kinase; Region: PGK; pfam00162 1356861003234 substrate binding site [chemical binding]; other site 1356861003235 hinge regions; other site 1356861003236 ADP binding site [chemical binding]; other site 1356861003237 catalytic site [active] 1356861003238 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1356861003239 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1356861003240 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1356861003241 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1356861003242 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1356861003243 TPP-binding site [chemical binding]; other site 1356861003244 dimer interface [polypeptide binding]; other site 1356861003245 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1356861003246 PYR/PP interface [polypeptide binding]; other site 1356861003247 dimer interface [polypeptide binding]; other site 1356861003248 TPP binding site [chemical binding]; other site 1356861003249 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1356861003250 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1356861003251 putative phosphate acyltransferase; Provisional; Region: PRK05331 1356861003252 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1356861003253 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1356861003254 dimer interface [polypeptide binding]; other site 1356861003255 active site 1356861003256 CoA binding pocket [chemical binding]; other site 1356861003257 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1356861003258 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1356861003259 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1356861003260 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1356861003261 NAD(P) binding site [chemical binding]; other site 1356861003262 homotetramer interface [polypeptide binding]; other site 1356861003263 homodimer interface [polypeptide binding]; other site 1356861003264 active site 1356861003265 acyl carrier protein; Provisional; Region: acpP; PRK00982 1356861003266 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1356861003267 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1356861003268 dimer interface [polypeptide binding]; other site 1356861003269 active site 1356861003270 YCII-related domain; Region: YCII; cl00999 1356861003271 putative transporter; Provisional; Region: PRK03699 1356861003272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861003273 putative substrate translocation pore; other site 1356861003274 Predicted membrane protein [Function unknown]; Region: COG2855 1356861003275 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1356861003276 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1356861003277 active site 1356861003278 dimerization interface [polypeptide binding]; other site 1356861003279 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1356861003280 NusB family; Region: NusB; pfam01029 1356861003281 putative RNA binding site [nucleotide binding]; other site 1356861003282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1356861003283 S-adenosylmethionine binding site [chemical binding]; other site 1356861003284 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1356861003285 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1356861003286 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1356861003287 active site 1356861003288 oligomerization interface [polypeptide binding]; other site 1356861003289 metal binding site [ion binding]; metal-binding site 1356861003290 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1356861003291 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1356861003292 active site 1356861003293 nucleotide binding site [chemical binding]; other site 1356861003294 HIGH motif; other site 1356861003295 KMSKS motif; other site 1356861003296 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1356861003297 tetramerization interface [polypeptide binding]; other site 1356861003298 active site 1356861003299 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1356861003300 AAA domain; Region: AAA_30; pfam13604 1356861003301 Family description; Region: UvrD_C_2; pfam13538 1356861003302 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1356861003303 Family description; Region: UvrD_C_2; pfam13538 1356861003304 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1356861003305 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 1356861003306 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 1356861003307 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1356861003308 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1356861003309 active site 1356861003310 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1356861003311 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1356861003312 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1356861003313 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1356861003314 active site 1356861003315 FMN binding site [chemical binding]; other site 1356861003316 substrate binding site [chemical binding]; other site 1356861003317 3Fe-4S cluster binding site [ion binding]; other site 1356861003318 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1356861003319 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1356861003320 non-specific DNA binding site [nucleotide binding]; other site 1356861003321 salt bridge; other site 1356861003322 sequence-specific DNA binding site [nucleotide binding]; other site 1356861003323 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1356861003324 Catalytic site [active] 1356861003325 Sporulation related domain; Region: SPOR; pfam05036 1356861003326 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1356861003327 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1356861003328 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1356861003329 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1356861003330 active site 1356861003331 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1356861003332 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1356861003333 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1356861003334 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1356861003335 dimer interface [polypeptide binding]; other site 1356861003336 motif 1; other site 1356861003337 active site 1356861003338 motif 2; other site 1356861003339 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1356861003340 putative deacylase active site [active] 1356861003341 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1356861003342 active site 1356861003343 motif 3; other site 1356861003344 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1356861003345 anticodon binding site; other site 1356861003346 methionine aminotransferase; Validated; Region: PRK09082 1356861003347 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1356861003348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861003349 homodimer interface [polypeptide binding]; other site 1356861003350 catalytic residue [active] 1356861003351 C-N hydrolase family amidase; Provisional; Region: PRK10438 1356861003352 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1356861003353 putative active site [active] 1356861003354 catalytic triad [active] 1356861003355 dimer interface [polypeptide binding]; other site 1356861003356 multimer interface [polypeptide binding]; other site 1356861003357 transcription antitermination factor NusB; Region: nusB; TIGR01951 1356861003358 putative RNA binding site [nucleotide binding]; other site 1356861003359 hypothetical protein; Provisional; Region: PRK05170 1356861003360 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1356861003361 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1356861003362 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1356861003363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1356861003364 dimerization interface [polypeptide binding]; other site 1356861003365 putative DNA binding site [nucleotide binding]; other site 1356861003366 putative Zn2+ binding site [ion binding]; other site 1356861003367 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1356861003368 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1356861003369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1356861003370 Coenzyme A binding pocket [chemical binding]; other site 1356861003371 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1356861003372 LysE type translocator; Region: LysE; cl00565 1356861003373 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1356861003374 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1356861003375 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1356861003376 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1356861003377 Ligand binding site; other site 1356861003378 Putative Catalytic site; other site 1356861003379 DXD motif; other site 1356861003380 inner membrane transport permease; Provisional; Region: PRK15066 1356861003381 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1356861003382 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1356861003383 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1356861003384 Walker A/P-loop; other site 1356861003385 ATP binding site [chemical binding]; other site 1356861003386 Q-loop/lid; other site 1356861003387 ABC transporter signature motif; other site 1356861003388 Walker B; other site 1356861003389 D-loop; other site 1356861003390 H-loop/switch region; other site 1356861003391 hypothetical protein; Provisional; Region: PRK10621 1356861003392 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1356861003393 Cupin domain; Region: Cupin_2; pfam07883 1356861003394 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1356861003395 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1356861003396 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1356861003397 active site 1356861003398 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1356861003399 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1356861003400 dimer interface [polypeptide binding]; other site 1356861003401 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1356861003402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1356861003403 Walker A motif; other site 1356861003404 ATP binding site [chemical binding]; other site 1356861003405 Walker B motif; other site 1356861003406 recombination factor protein RarA; Provisional; Region: PRK14700 1356861003407 arginine finger; other site 1356861003408 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1356861003409 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1356861003410 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1356861003411 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1356861003412 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1356861003413 catalytic residues [active] 1356861003414 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1356861003415 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1356861003416 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1356861003417 RNA binding site [nucleotide binding]; other site 1356861003418 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1356861003419 multimer interface [polypeptide binding]; other site 1356861003420 Walker A motif; other site 1356861003421 ATP binding site [chemical binding]; other site 1356861003422 Walker B motif; other site 1356861003423 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1356861003424 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 1356861003425 active site 1356861003426 substrate binding site [chemical binding]; other site 1356861003427 metal binding site [ion binding]; metal-binding site 1356861003428 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1356861003429 metal-binding site 1356861003430 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1356861003431 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1356861003432 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1356861003433 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1356861003434 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1356861003435 metal-binding site 1356861003436 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1356861003437 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1356861003438 active site 1356861003439 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1356861003440 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1356861003441 Walker A/P-loop; other site 1356861003442 ATP binding site [chemical binding]; other site 1356861003443 Q-loop/lid; other site 1356861003444 ABC transporter signature motif; other site 1356861003445 Walker B; other site 1356861003446 D-loop; other site 1356861003447 H-loop/switch region; other site 1356861003448 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1356861003449 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1356861003450 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1356861003451 active site 1356861003452 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1356861003453 Rhamnan synthesis protein F; Region: RgpF; pfam05045 1356861003454 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1356861003455 active site 1356861003456 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1356861003457 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1356861003458 inhibitor-cofactor binding pocket; inhibition site 1356861003459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861003460 catalytic residue [active] 1356861003461 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 1356861003462 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1356861003463 putative trimer interface [polypeptide binding]; other site 1356861003464 putative active site [active] 1356861003465 putative substrate binding site [chemical binding]; other site 1356861003466 putative CoA binding site [chemical binding]; other site 1356861003467 WxcM-like, C-terminal; Region: FdtA; pfam05523 1356861003468 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1356861003469 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1356861003470 active site 1356861003471 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1356861003472 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1356861003473 active site 1356861003474 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1356861003475 AMP-binding enzyme; Region: AMP-binding; pfam00501 1356861003476 acyl-activating enzyme (AAE) consensus motif; other site 1356861003477 AMP binding site [chemical binding]; other site 1356861003478 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1356861003479 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1356861003480 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1356861003481 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1356861003482 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1356861003483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1356861003484 NAD(P) binding site [chemical binding]; other site 1356861003485 active site 1356861003486 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1356861003487 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1356861003488 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1356861003489 putative trimer interface [polypeptide binding]; other site 1356861003490 putative CoA binding site [chemical binding]; other site 1356861003491 WbqC-like protein family; Region: WbqC; pfam08889 1356861003492 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1356861003493 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1356861003494 inhibitor-cofactor binding pocket; inhibition site 1356861003495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861003496 catalytic residue [active] 1356861003497 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1356861003498 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1356861003499 active site 1356861003500 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1356861003501 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1356861003502 putative trimer interface [polypeptide binding]; other site 1356861003503 putative CoA binding site [chemical binding]; other site 1356861003504 WbqC-like protein family; Region: WbqC; pfam08889 1356861003505 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1356861003506 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1356861003507 inhibitor-cofactor binding pocket; inhibition site 1356861003508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1356861003509 catalytic residue [active] 1356861003510 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1356861003511 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1356861003512 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1356861003513 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1356861003514 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1356861003515 dimer interface [polypeptide binding]; other site 1356861003516 active site 1356861003517 CoA binding pocket [chemical binding]; other site 1356861003518 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1356861003519 putative trimer interface [polypeptide binding]; other site 1356861003520 putative CoA binding site [chemical binding]; other site 1356861003521 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1356861003522 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1356861003523 NAD binding site [chemical binding]; other site 1356861003524 substrate binding site [chemical binding]; other site 1356861003525 homodimer interface [polypeptide binding]; other site 1356861003526 active site 1356861003527 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1356861003528 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1356861003529 NADP binding site [chemical binding]; other site 1356861003530 active site 1356861003531 putative substrate binding site [chemical binding]; other site 1356861003532 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1356861003533 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1356861003534 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1356861003535 substrate binding site; other site 1356861003536 tetramer interface; other site 1356861003537 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1356861003538 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1356861003539 NADP binding site [chemical binding]; other site 1356861003540 active site 1356861003541 putative substrate binding site [chemical binding]; other site 1356861003542 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1356861003543 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1356861003544 NADP-binding site; other site 1356861003545 homotetramer interface [polypeptide binding]; other site 1356861003546 substrate binding site [chemical binding]; other site 1356861003547 homodimer interface [polypeptide binding]; other site 1356861003548 active site 1356861003549 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1356861003550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1356861003551 NAD(P) binding site [chemical binding]; other site 1356861003552 active site 1356861003553 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1356861003554 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1356861003555 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1356861003556 NAD(P) binding site [chemical binding]; other site 1356861003557 homodimer interface [polypeptide binding]; other site 1356861003558 substrate binding site [chemical binding]; other site 1356861003559 active site 1356861003560 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1356861003561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1356861003562 ATP binding site [chemical binding]; other site 1356861003563 putative Mg++ binding site [ion binding]; other site 1356861003564 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1356861003565 nucleotide binding region [chemical binding]; other site 1356861003566 ATP-binding site [chemical binding]; other site 1356861003567 Helicase associated domain (HA2); Region: HA2; pfam04408 1356861003568 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1356861003569 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1356861003570 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1356861003571 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1356861003572 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1356861003573 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1356861003574 acyl-activating enzyme (AAE) consensus motif; other site 1356861003575 putative AMP binding site [chemical binding]; other site 1356861003576 putative active site [active] 1356861003577 putative CoA binding site [chemical binding]; other site 1356861003578 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1356861003579 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1356861003580 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1356861003581 active site 1356861003582 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1356861003583 Acyl CoA binding protein; Region: ACBP; pfam00887 1356861003584 acyl-CoA binding pocket [chemical binding]; other site 1356861003585 CoA binding site [chemical binding]; other site 1356861003586 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1356861003587 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1356861003588 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1356861003589 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1356861003590 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1356861003591 substrate binding site [chemical binding]; other site 1356861003592 oxyanion hole (OAH) forming residues; other site 1356861003593 trimer interface [polypeptide binding]; other site 1356861003594 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1356861003595 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1356861003596 dimer interface [polypeptide binding]; other site 1356861003597 active site 1356861003598 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1356861003599 CoenzymeA binding site [chemical binding]; other site 1356861003600 subunit interaction site [polypeptide binding]; other site 1356861003601 PHB binding site; other site 1356861003602 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1356861003603 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1356861003604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861003605 putative substrate translocation pore; other site 1356861003606 Arginase family; Region: Arginase; cd09989 1356861003607 active site 1356861003608 Mn binding site [ion binding]; other site 1356861003609 oligomer interface [polypeptide binding]; other site 1356861003610 ornithine cyclodeaminase; Validated; Region: PRK07589 1356861003611 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1356861003612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 1356861003613 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 1356861003614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1356861003615 S-adenosylmethionine binding site [chemical binding]; other site 1356861003616 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1356861003617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1356861003618 active site 1356861003619 phosphorylation site [posttranslational modification] 1356861003620 intermolecular recognition site; other site 1356861003621 dimerization interface [polypeptide binding]; other site 1356861003622 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1356861003623 DNA binding site [nucleotide binding] 1356861003624 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1356861003625 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1356861003626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1356861003627 NAD(P) binding site [chemical binding]; other site 1356861003628 active site 1356861003629 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1356861003630 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1356861003631 ribonuclease R; Region: RNase_R; TIGR02063 1356861003632 RNB domain; Region: RNB; pfam00773 1356861003633 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1356861003634 RNA binding site [nucleotide binding]; other site 1356861003635 ribonuclease III; Reviewed; Region: rnc; PRK00102 1356861003636 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1356861003637 dimerization interface [polypeptide binding]; other site 1356861003638 active site 1356861003639 metal binding site [ion binding]; metal-binding site 1356861003640 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1356861003641 dsRNA binding site [nucleotide binding]; other site 1356861003642 signal peptidase I; Provisional; Region: PRK10861 1356861003643 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1356861003644 Catalytic site [active] 1356861003645 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1356861003646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1356861003647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1356861003648 active site 1356861003649 phosphorylation site [posttranslational modification] 1356861003650 intermolecular recognition site; other site 1356861003651 dimerization interface [polypeptide binding]; other site 1356861003652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1356861003653 DNA binding site [nucleotide binding] 1356861003654 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1356861003655 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1356861003656 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1356861003657 dimerization interface [polypeptide binding]; other site 1356861003658 active site 1356861003659 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1356861003660 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1356861003661 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1356861003662 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1356861003663 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1356861003664 substrate binding pocket [chemical binding]; other site 1356861003665 chain length determination region; other site 1356861003666 substrate-Mg2+ binding site; other site 1356861003667 catalytic residues [active] 1356861003668 aspartate-rich region 1; other site 1356861003669 active site lid residues [active] 1356861003670 aspartate-rich region 2; other site 1356861003671 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1356861003672 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1356861003673 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1356861003674 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1356861003675 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1356861003676 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1356861003677 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1356861003678 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1356861003679 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1356861003680 active site 1356861003681 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1356861003682 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1356861003683 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1356861003684 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1356861003685 trimer interface [polypeptide binding]; other site 1356861003686 active site 1356861003687 UDP-GlcNAc binding site [chemical binding]; other site 1356861003688 lipid binding site [chemical binding]; lipid-binding site 1356861003689 periplasmic chaperone; Provisional; Region: PRK10780 1356861003690 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1356861003691 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1356861003692 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1356861003693 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1356861003694 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1356861003695 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1356861003696 Surface antigen; Region: Bac_surface_Ag; pfam01103 1356861003697 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1356861003698 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1356861003699 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1356861003700 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1356861003701 DNA gyrase subunit A; Validated; Region: PRK05560 1356861003702 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1356861003703 CAP-like domain; other site 1356861003704 active site 1356861003705 primary dimer interface [polypeptide binding]; other site 1356861003706 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1356861003707 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1356861003708 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1356861003709 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1356861003710 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1356861003711 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1356861003712 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1356861003713 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1356861003714 ligand binding site [chemical binding]; other site 1356861003715 active site 1356861003716 UGI interface [polypeptide binding]; other site 1356861003717 catalytic site [active] 1356861003718 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1356861003719 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1356861003720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1356861003721 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1356861003722 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1356861003723 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1356861003724 E3 interaction surface; other site 1356861003725 lipoyl attachment site [posttranslational modification]; other site 1356861003726 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1356861003727 E3 interaction surface; other site 1356861003728 lipoyl attachment site [posttranslational modification]; other site 1356861003729 e3 binding domain; Region: E3_binding; pfam02817 1356861003730 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1356861003731 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1356861003732 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1356861003733 dimer interface [polypeptide binding]; other site 1356861003734 TPP-binding site [chemical binding]; other site 1356861003735 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1356861003736 dephospho-CoA kinase; Region: TIGR00152 1356861003737 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1356861003738 CoA-binding site [chemical binding]; other site 1356861003739 ATP-binding [chemical binding]; other site 1356861003740 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1356861003741 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1356861003742 active site 1356861003743 HIGH motif; other site 1356861003744 dimer interface [polypeptide binding]; other site 1356861003745 KMSKS motif; other site 1356861003746 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1356861003747 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1356861003748 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1356861003749 putative active site [active] 1356861003750 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1356861003751 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1356861003752 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1356861003753 MutS domain I; Region: MutS_I; pfam01624 1356861003754 MutS domain II; Region: MutS_II; pfam05188 1356861003755 MutS domain III; Region: MutS_III; pfam05192 1356861003756 MutS domain V; Region: MutS_V; pfam00488 1356861003757 Walker A/P-loop; other site 1356861003758 ATP binding site [chemical binding]; other site 1356861003759 Q-loop/lid; other site 1356861003760 ABC transporter signature motif; other site 1356861003761 Walker B; other site 1356861003762 D-loop; other site 1356861003763 H-loop/switch region; other site 1356861003764 preprotein translocase subunit SecB; Validated; Region: PRK05751 1356861003765 SecA binding site; other site 1356861003766 Preprotein binding site; other site 1356861003767 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1356861003768 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1356861003769 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1356861003770 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1356861003771 active site 1356861003772 DNA binding site [nucleotide binding] 1356861003773 Int/Topo IB signature motif; other site 1356861003774 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1356861003775 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1356861003776 aromatic amino acid transport protein; Region: araaP; TIGR00837 1356861003777 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 1356861003778 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1356861003779 HSP70 interaction site [polypeptide binding]; other site 1356861003780 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1356861003781 substrate binding site [polypeptide binding]; other site 1356861003782 dimer interface [polypeptide binding]; other site 1356861003783 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1356861003784 mercuric reductase; Validated; Region: PRK06370 1356861003785 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1356861003786 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1356861003787 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1356861003788 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1356861003789 Amino acid permease; Region: AA_permease_2; pfam13520 1356861003790 glutamate dehydrogenase; Provisional; Region: PRK09414 1356861003791 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1356861003792 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1356861003793 NAD(P) binding site [chemical binding]; other site 1356861003794 HI0933-like protein; Region: HI0933_like; pfam03486 1356861003795 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1356861003796 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1356861003797 DNA-binding interface [nucleotide binding]; DNA binding site 1356861003798 short chain dehydrogenase; Provisional; Region: PRK05993 1356861003799 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1356861003800 NADP binding site [chemical binding]; other site 1356861003801 active site 1356861003802 steroid binding site; other site 1356861003803 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1356861003804 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1356861003805 ring oligomerisation interface [polypeptide binding]; other site 1356861003806 ATP/Mg binding site [chemical binding]; other site 1356861003807 stacking interactions; other site 1356861003808 hinge regions; other site 1356861003809 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1356861003810 oligomerisation interface [polypeptide binding]; other site 1356861003811 mobile loop; other site 1356861003812 roof hairpin; other site 1356861003813 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1356861003814 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1356861003815 G1 box; other site 1356861003816 GTP/Mg2+ binding site [chemical binding]; other site 1356861003817 Switch I region; other site 1356861003818 G2 box; other site 1356861003819 G3 box; other site 1356861003820 Switch II region; other site 1356861003821 G4 box; other site 1356861003822 G5 box; other site 1356861003823 Nucleoside recognition; Region: Gate; pfam07670 1356861003824 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1356861003825 Nucleoside recognition; Region: Gate; pfam07670 1356861003826 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1356861003827 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1356861003828 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1356861003829 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1356861003830 dimer interface [polypeptide binding]; other site 1356861003831 active site 1356861003832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1356861003833 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1356861003834 NAD(P) binding site [chemical binding]; other site 1356861003835 active site 1356861003836 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1356861003837 active site 2 [active] 1356861003838 active site 1 [active] 1356861003839 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1356861003840 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1356861003841 dimer interface [polypeptide binding]; other site 1356861003842 active site 1356861003843 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1356861003844 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1356861003845 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1356861003846 putative acyl-acceptor binding pocket; other site 1356861003847 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1356861003848 acyl carrier protein; Provisional; Region: PRK05350 1356861003849 Predicted membrane protein [Function unknown]; Region: COG4648 1356861003850 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1356861003851 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1356861003852 acyl-activating enzyme (AAE) consensus motif; other site 1356861003853 AMP binding site [chemical binding]; other site 1356861003854 active site 1356861003855 CoA binding site [chemical binding]; other site 1356861003856 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1356861003857 active site 2 [active] 1356861003858 active site 1 [active] 1356861003859 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1356861003860 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1356861003861 Ligand binding site; other site 1356861003862 Putative Catalytic site; other site 1356861003863 DXD motif; other site 1356861003864 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1356861003865 putative acyl-acceptor binding pocket; other site 1356861003866 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1356861003867 active site 1356861003868 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1356861003869 Predicted exporter [General function prediction only]; Region: COG4258 1356861003870 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 1356861003871 hypothetical protein; Validated; Region: PRK02101 1356861003872 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1356861003873 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1356861003874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1356861003875 S-adenosylmethionine binding site [chemical binding]; other site 1356861003876 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1356861003877 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1356861003878 RF-1 domain; Region: RF-1; pfam00472 1356861003879 glutamyl-tRNA reductase; Provisional; Region: PRK13940 1356861003880 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1356861003881 tRNA; other site 1356861003882 putative tRNA binding site [nucleotide binding]; other site 1356861003883 putative NADP binding site [chemical binding]; other site 1356861003884 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1356861003885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1356861003886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1356861003887 TPR motif; other site 1356861003888 binding surface 1356861003889 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1356861003890 Trp docking motif [polypeptide binding]; other site 1356861003891 PQQ-like domain; Region: PQQ_2; pfam13360 1356861003892 PQQ-like domain; Region: PQQ_2; pfam13360 1356861003893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861003894 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1356861003895 putative substrate translocation pore; other site 1356861003896 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1356861003897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1356861003898 Mg2+ binding site [ion binding]; other site 1356861003899 G-X-G motif; other site 1356861003900 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1356861003901 anchoring element; other site 1356861003902 dimer interface [polypeptide binding]; other site 1356861003903 ATP binding site [chemical binding]; other site 1356861003904 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1356861003905 active site 1356861003906 metal binding site [ion binding]; metal-binding site 1356861003907 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1356861003908 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1356861003909 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1356861003910 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1356861003911 amidase catalytic site [active] 1356861003912 Zn binding residues [ion binding]; other site 1356861003913 substrate binding site [chemical binding]; other site 1356861003914 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1356861003915 putative active site [active] 1356861003916 Ap4A binding site [chemical binding]; other site 1356861003917 nudix motif; other site 1356861003918 putative metal binding site [ion binding]; other site 1356861003919 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 1356861003920 classical (c) SDRs; Region: SDR_c; cd05233 1356861003921 NAD(P) binding site [chemical binding]; other site 1356861003922 active site 1356861003923 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 1356861003924 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1356861003925 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1356861003926 Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476 1356861003927 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1356861003928 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1356861003929 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1356861003930 active site 1356861003931 DNA binding site [nucleotide binding] 1356861003932 Int/Topo IB signature motif; other site 1356861003933 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1356861003934 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1356861003935 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 1356861003936 RimM N-terminal domain; Region: RimM; pfam01782 1356861003937 PRC-barrel domain; Region: PRC; pfam05239 1356861003938 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1356861003939 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1356861003940 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1356861003941 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1356861003942 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1356861003943 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1356861003944 Di-iron ligands [ion binding]; other site 1356861003945 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1356861003946 UGMP family protein; Validated; Region: PRK09604 1356861003947 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 1356861003948 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1356861003949 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1356861003950 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1356861003951 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1356861003952 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1356861003953 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1356861003954 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1356861003955 cleft; other site 1356861003956 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1356861003957 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 1356861003958 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1356861003959 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 1356861003960 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1356861003961 DNA binding site [nucleotide binding] 1356861003962 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1356861003963 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1356861003964 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1356861003965 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1356861003966 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1356861003967 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1356861003968 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1356861003969 RPB3 interaction site [polypeptide binding]; other site 1356861003970 RPB1 interaction site [polypeptide binding]; other site 1356861003971 RPB11 interaction site [polypeptide binding]; other site 1356861003972 RPB10 interaction site [polypeptide binding]; other site 1356861003973 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1356861003974 core dimer interface [polypeptide binding]; other site 1356861003975 peripheral dimer interface [polypeptide binding]; other site 1356861003976 L10 interface [polypeptide binding]; other site 1356861003977 L11 interface [polypeptide binding]; other site 1356861003978 putative EF-Tu interaction site [polypeptide binding]; other site 1356861003979 putative EF-G interaction site [polypeptide binding]; other site 1356861003980 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1356861003981 23S rRNA interface [nucleotide binding]; other site 1356861003982 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1356861003983 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1356861003984 mRNA/rRNA interface [nucleotide binding]; other site 1356861003985 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1356861003986 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1356861003987 23S rRNA interface [nucleotide binding]; other site 1356861003988 L7/L12 interface [polypeptide binding]; other site 1356861003989 putative thiostrepton binding site; other site 1356861003990 L25 interface [polypeptide binding]; other site 1356861003991 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1356861003992 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1356861003993 putative homodimer interface [polypeptide binding]; other site 1356861003994 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1356861003995 heterodimer interface [polypeptide binding]; other site 1356861003996 homodimer interface [polypeptide binding]; other site 1356861003997 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1356861003998 elongation factor Tu; Reviewed; Region: PRK00049 1356861003999 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1356861004000 G1 box; other site 1356861004001 GEF interaction site [polypeptide binding]; other site 1356861004002 GTP/Mg2+ binding site [chemical binding]; other site 1356861004003 Switch I region; other site 1356861004004 G2 box; other site 1356861004005 G3 box; other site 1356861004006 Switch II region; other site 1356861004007 G4 box; other site 1356861004008 G5 box; other site 1356861004009 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1356861004010 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1356861004011 Antibiotic Binding Site [chemical binding]; other site 1356861004012 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1356861004013 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1356861004014 amphipathic channel; other site 1356861004015 Asn-Pro-Ala signature motifs; other site 1356861004016 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1356861004017 glycerol kinase; Provisional; Region: glpK; PRK00047 1356861004018 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1356861004019 N- and C-terminal domain interface [polypeptide binding]; other site 1356861004020 active site 1356861004021 MgATP binding site [chemical binding]; other site 1356861004022 catalytic site [active] 1356861004023 metal binding site [ion binding]; metal-binding site 1356861004024 glycerol binding site [chemical binding]; other site 1356861004025 homotetramer interface [polypeptide binding]; other site 1356861004026 homodimer interface [polypeptide binding]; other site 1356861004027 FBP binding site [chemical binding]; other site 1356861004028 protein IIAGlc interface [polypeptide binding]; other site 1356861004029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861004030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1356861004031 putative substrate translocation pore; other site 1356861004032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861004033 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1356861004034 putative substrate translocation pore; other site 1356861004035 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1356861004036 Part of AAA domain; Region: AAA_19; pfam13245 1356861004037 Family description; Region: UvrD_C_2; pfam13538 1356861004038 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1356861004039 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1356861004040 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1356861004041 P loop; other site 1356861004042 GTP binding site [chemical binding]; other site 1356861004043 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1356861004044 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1356861004045 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1356861004046 G1 box; other site 1356861004047 putative GEF interaction site [polypeptide binding]; other site 1356861004048 GTP/Mg2+ binding site [chemical binding]; other site 1356861004049 Switch I region; other site 1356861004050 G2 box; other site 1356861004051 G3 box; other site 1356861004052 Switch II region; other site 1356861004053 G4 box; other site 1356861004054 G5 box; other site 1356861004055 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1356861004056 thymidylate kinase; Validated; Region: tmk; PRK00698 1356861004057 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1356861004058 TMP-binding site; other site 1356861004059 ATP-binding site [chemical binding]; other site 1356861004060 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1356861004061 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1356861004062 Nucleoside recognition; Region: Gate; pfam07670 1356861004063 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1356861004064 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1356861004065 intersubunit interface [polypeptide binding]; other site 1356861004066 active site 1356861004067 catalytic residue [active] 1356861004068 phosphopentomutase; Provisional; Region: PRK05362 1356861004069 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1356861004070 pantothenate kinase; Reviewed; Region: PRK13324 1356861004071 DNA polymerase I; Provisional; Region: PRK05755 1356861004072 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1356861004073 active site 1356861004074 metal binding site 1 [ion binding]; metal-binding site 1356861004075 putative 5' ssDNA interaction site; other site 1356861004076 metal binding site 3; metal-binding site 1356861004077 metal binding site 2 [ion binding]; metal-binding site 1356861004078 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1356861004079 putative DNA binding site [nucleotide binding]; other site 1356861004080 putative metal binding site [ion binding]; other site 1356861004081 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1356861004082 active site 1356861004083 catalytic site [active] 1356861004084 substrate binding site [chemical binding]; other site 1356861004085 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1356861004086 active site 1356861004087 DNA binding site [nucleotide binding] 1356861004088 catalytic site [active] 1356861004089 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1356861004090 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1356861004091 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1356861004092 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1356861004093 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1356861004094 Walker A/P-loop; other site 1356861004095 ATP binding site [chemical binding]; other site 1356861004096 Q-loop/lid; other site 1356861004097 ABC transporter signature motif; other site 1356861004098 Walker B; other site 1356861004099 D-loop; other site 1356861004100 H-loop/switch region; other site 1356861004101 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 1356861004102 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1356861004103 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1356861004104 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1356861004105 HlyD family secretion protein; Region: HlyD_3; pfam13437 1356861004106 multidrug efflux protein; Reviewed; Region: PRK09579 1356861004107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861004108 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1356861004109 putative substrate translocation pore; other site 1356861004110 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1356861004111 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1356861004112 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1356861004113 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1356861004114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1356861004115 dimer interface [polypeptide binding]; other site 1356861004116 phosphorylation site [posttranslational modification] 1356861004117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1356861004118 ATP binding site [chemical binding]; other site 1356861004119 Mg2+ binding site [ion binding]; other site 1356861004120 G-X-G motif; other site 1356861004121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1356861004122 TIGR01777 family protein; Region: yfcH 1356861004123 NAD(P) binding site [chemical binding]; other site 1356861004124 active site 1356861004125 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1356861004126 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1356861004127 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1356861004128 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1356861004129 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1356861004130 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1356861004131 aconitate hydratase; Validated; Region: PRK09277 1356861004132 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1356861004133 substrate binding site [chemical binding]; other site 1356861004134 ligand binding site [chemical binding]; other site 1356861004135 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1356861004136 substrate binding site [chemical binding]; other site 1356861004137 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1356861004138 GtrA-like protein; Region: GtrA; pfam04138 1356861004139 HemN family oxidoreductase; Provisional; Region: PRK05660 1356861004140 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1356861004141 FeS/SAM binding site; other site 1356861004142 HemN C-terminal domain; Region: HemN_C; pfam06969 1356861004143 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1356861004144 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1356861004145 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1356861004146 triosephosphate isomerase; Provisional; Region: PRK14567 1356861004147 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1356861004148 substrate binding site [chemical binding]; other site 1356861004149 dimer interface [polypeptide binding]; other site 1356861004150 catalytic triad [active] 1356861004151 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 1356861004152 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1356861004153 active site 1356861004154 substrate binding site [chemical binding]; other site 1356861004155 metal binding site [ion binding]; metal-binding site 1356861004156 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1356861004157 active site 1356861004158 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1356861004159 E3 interaction surface; other site 1356861004160 lipoyl attachment site [posttranslational modification]; other site 1356861004161 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1356861004162 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1356861004163 E3 interaction surface; other site 1356861004164 lipoyl attachment site [posttranslational modification]; other site 1356861004165 e3 binding domain; Region: E3_binding; pfam02817 1356861004166 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1356861004167 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1356861004168 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1356861004169 TPP-binding site [chemical binding]; other site 1356861004170 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1356861004171 PYR/PP interface [polypeptide binding]; other site 1356861004172 dimer interface [polypeptide binding]; other site 1356861004173 TPP binding site [chemical binding]; other site 1356861004174 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1356861004175 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1356861004176 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1356861004177 L-aspartate oxidase; Provisional; Region: PRK06175 1356861004178 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1356861004179 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1356861004180 SdhC subunit interface [polypeptide binding]; other site 1356861004181 proximal heme binding site [chemical binding]; other site 1356861004182 cardiolipin binding site; other site 1356861004183 Iron-sulfur protein interface; other site 1356861004184 proximal quinone binding site [chemical binding]; other site 1356861004185 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1356861004186 Iron-sulfur protein interface; other site 1356861004187 proximal quinone binding site [chemical binding]; other site 1356861004188 SdhD (CybS) interface [polypeptide binding]; other site 1356861004189 proximal heme binding site [chemical binding]; other site 1356861004190 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1356861004191 dimer interface [polypeptide binding]; other site 1356861004192 Citrate synthase; Region: Citrate_synt; pfam00285 1356861004193 active site 1356861004194 citrylCoA binding site [chemical binding]; other site 1356861004195 NADH binding [chemical binding]; other site 1356861004196 cationic pore residues; other site 1356861004197 oxalacetate/citrate binding site [chemical binding]; other site 1356861004198 coenzyme A binding site [chemical binding]; other site 1356861004199 catalytic triad [active] 1356861004200 muropeptide transporter; Validated; Region: ampG; cl17669 1356861004201 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1356861004202 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1356861004203 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1356861004204 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1356861004205 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1356861004206 putative GSH binding site [chemical binding]; other site 1356861004207 catalytic residues [active] 1356861004208 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 1356861004209 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1356861004210 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1356861004211 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1356861004212 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1356861004213 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 1356861004214 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1356861004215 gamma subunit interface [polypeptide binding]; other site 1356861004216 epsilon subunit interface [polypeptide binding]; other site 1356861004217 LBP interface [polypeptide binding]; other site 1356861004218 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1356861004219 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1356861004220 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1356861004221 alpha subunit interaction interface [polypeptide binding]; other site 1356861004222 Walker A motif; other site 1356861004223 ATP binding site [chemical binding]; other site 1356861004224 Walker B motif; other site 1356861004225 inhibitor binding site; inhibition site 1356861004226 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1356861004227 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1356861004228 core domain interface [polypeptide binding]; other site 1356861004229 delta subunit interface [polypeptide binding]; other site 1356861004230 epsilon subunit interface [polypeptide binding]; other site 1356861004231 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1356861004232 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1356861004233 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1356861004234 beta subunit interaction interface [polypeptide binding]; other site 1356861004235 Walker A motif; other site 1356861004236 ATP binding site [chemical binding]; other site 1356861004237 Walker B motif; other site 1356861004238 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1356861004239 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1356861004240 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1356861004241 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1356861004242 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1356861004243 F0F1 ATP synthase subunit C; Provisional; Region: PRK13464 1356861004244 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1356861004245 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1356861004246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861004247 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1356861004248 putative substrate translocation pore; other site 1356861004249 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1356861004250 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1356861004251 RNA binding surface [nucleotide binding]; other site 1356861004252 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1356861004253 active site 1356861004254 Predicted ATPase [General function prediction only]; Region: COG1485 1356861004255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861004256 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1356861004257 putative substrate translocation pore; other site 1356861004258 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1356861004259 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1356861004260 dimer interface [polypeptide binding]; other site 1356861004261 motif 1; other site 1356861004262 active site 1356861004263 motif 2; other site 1356861004264 motif 3; other site 1356861004265 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1356861004266 anticodon binding site; other site 1356861004267 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1356861004268 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1356861004269 translation initiation factor IF-2; Region: IF-2; TIGR00487 1356861004270 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1356861004271 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1356861004272 G1 box; other site 1356861004273 putative GEF interaction site [polypeptide binding]; other site 1356861004274 GTP/Mg2+ binding site [chemical binding]; other site 1356861004275 Switch I region; other site 1356861004276 G2 box; other site 1356861004277 G3 box; other site 1356861004278 Switch II region; other site 1356861004279 G4 box; other site 1356861004280 G5 box; other site 1356861004281 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1356861004282 Translation-initiation factor 2; Region: IF-2; pfam11987 1356861004283 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1356861004284 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1356861004285 NusA N-terminal domain; Region: NusA_N; pfam08529 1356861004286 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1356861004287 RNA binding site [nucleotide binding]; other site 1356861004288 homodimer interface [polypeptide binding]; other site 1356861004289 NusA-like KH domain; Region: KH_5; pfam13184 1356861004290 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1356861004291 G-X-X-G motif; other site 1356861004292 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1356861004293 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1356861004294 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1356861004295 Sm and related proteins; Region: Sm_like; cl00259 1356861004296 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1356861004297 putative oligomer interface [polypeptide binding]; other site 1356861004298 putative RNA binding site [nucleotide binding]; other site 1356861004299 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1356861004300 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1356861004301 substrate binding site [chemical binding]; other site 1356861004302 active site 1356861004303 Membrane fusogenic activity; Region: BMFP; pfam04380 1356861004304 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1356861004305 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1356861004306 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1356861004307 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1356861004308 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1356861004309 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1356861004310 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1356861004311 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1356861004312 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1356861004313 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1356861004314 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1356861004315 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1356861004316 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1356861004317 NADH dehydrogenase subunit G; Validated; Region: PRK09129 1356861004318 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1356861004319 catalytic loop [active] 1356861004320 iron binding site [ion binding]; other site 1356861004321 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1356861004322 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1356861004323 molybdopterin cofactor binding site; other site 1356861004324 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1356861004325 SLBB domain; Region: SLBB; pfam10531 1356861004326 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1356861004327 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1356861004328 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1356861004329 putative dimer interface [polypeptide binding]; other site 1356861004330 [2Fe-2S] cluster binding site [ion binding]; other site 1356861004331 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1356861004332 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1356861004333 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1356861004334 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1356861004335 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1356861004336 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1356861004337 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1356861004338 metal binding site 2 [ion binding]; metal-binding site 1356861004339 putative DNA binding helix; other site 1356861004340 metal binding site 1 [ion binding]; metal-binding site 1356861004341 dimer interface [polypeptide binding]; other site 1356861004342 structural Zn2+ binding site [ion binding]; other site 1356861004343 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1356861004344 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1356861004345 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1356861004346 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1356861004347 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1356861004348 IucA / IucC family; Region: IucA_IucC; pfam04183 1356861004349 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1356861004350 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1356861004351 IucA / IucC family; Region: IucA_IucC; pfam04183 1356861004352 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1356861004353 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1356861004354 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1356861004355 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 1356861004356 muropeptide transporter; Validated; Region: ampG; cl17669 1356861004357 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1356861004358 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1356861004359 GatB domain; Region: GatB_Yqey; smart00845 1356861004360 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1356861004361 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1356861004362 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1356861004363 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1356861004364 E3 interaction surface; other site 1356861004365 lipoyl attachment site [posttranslational modification]; other site 1356861004366 adenylosuccinate lyase; Provisional; Region: PRK07492 1356861004367 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1356861004368 tetramer interface [polypeptide binding]; other site 1356861004369 active site 1356861004370 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1356861004371 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1356861004372 dimerization interface [polypeptide binding]; other site 1356861004373 ATP binding site [chemical binding]; other site 1356861004374 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1356861004375 dimerization interface [polypeptide binding]; other site 1356861004376 ATP binding site [chemical binding]; other site 1356861004377 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1356861004378 putative active site [active] 1356861004379 catalytic triad [active] 1356861004380 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1356861004381 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1356861004382 active site 1356861004383 tetramer interface [polypeptide binding]; other site 1356861004384 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1356861004385 active site 1356861004386 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1356861004387 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1356861004388 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1356861004389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1356861004390 putative protease; Provisional; Region: PRK15452 1356861004391 Peptidase family U32; Region: Peptidase_U32; pfam01136 1356861004392 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1356861004393 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1356861004394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861004395 putative substrate translocation pore; other site 1356861004396 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 1356861004397 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1356861004398 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1356861004399 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1356861004400 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1356861004401 Amino acid permease; Region: AA_permease_2; pfam13520 1356861004402 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1356861004403 GTP1/OBG; Region: GTP1_OBG; pfam01018 1356861004404 Obg GTPase; Region: Obg; cd01898 1356861004405 G1 box; other site 1356861004406 GTP/Mg2+ binding site [chemical binding]; other site 1356861004407 Switch I region; other site 1356861004408 G2 box; other site 1356861004409 G3 box; other site 1356861004410 Switch II region; other site 1356861004411 G4 box; other site 1356861004412 G5 box; other site 1356861004413 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1356861004414 aromatic amino acid transport protein; Region: araaP; TIGR00837 1356861004415 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1356861004416 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1356861004417 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 1356861004418 Predicted transcriptional regulators [Transcription]; Region: COG1733 1356861004419 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1356861004420 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1356861004421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1356861004422 putative substrate translocation pore; other site