-- dump date   	20140619_094930
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1163389000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1163389000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1163389000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1163389000004	Walker A motif; other site
1163389000005	ATP binding site [chemical binding]; other site
1163389000006	Walker B motif; other site
1163389000007	arginine finger; other site
1163389000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1163389000009	DnaA box-binding interface [nucleotide binding]; other site
1163389000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
1163389000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1163389000012	putative DNA binding surface [nucleotide binding]; other site
1163389000013	dimer interface [polypeptide binding]; other site
1163389000014	beta-clamp/clamp loader binding surface; other site
1163389000015	beta-clamp/translesion DNA polymerase binding surface; other site
1163389000016	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1163389000017	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
1163389000018	Cl binding site [ion binding]; other site
1163389000019	oligomer interface [polypeptide binding]; other site
1163389000020	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1163389000021	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1163389000022	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1163389000023	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1163389000024	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1163389000025	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1163389000026	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1163389000027	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1163389000028	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1163389000029	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1163389000030	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1163389000031	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
1163389000032	substrate binding site [chemical binding]; other site
1163389000033	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1163389000034	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1163389000035	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1163389000036	catalytic site [active]
1163389000037	subunit interface [polypeptide binding]; other site
1163389000038	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1163389000039	catalytic core [active]
1163389000040	dihydroorotase; Reviewed; Region: PRK09236
1163389000041	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1163389000042	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
1163389000043	active site
1163389000044	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1163389000045	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1163389000046	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
1163389000047	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1163389000048	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1163389000049	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1163389000050	HlyD family secretion protein; Region: HlyD_3; pfam13437
1163389000051	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
1163389000052	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1163389000053	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1163389000054	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1163389000055	dimerization interface [polypeptide binding]; other site
1163389000056	SOUL heme-binding protein; Region: SOUL; pfam04832
1163389000057	Chorismate mutase type II; Region: CM_2; cl00693
1163389000058	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1163389000059	active site
1163389000060	dimer interface [polypeptide binding]; other site
1163389000061	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1163389000062	phosphate binding site [ion binding]; other site
1163389000063	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1163389000064	putative active site [active]
1163389000065	dimerization interface [polypeptide binding]; other site
1163389000066	putative tRNAtyr binding site [nucleotide binding]; other site
1163389000067	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1163389000068	putative transporter; Provisional; Region: PRK03699
1163389000069	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1163389000070	substrate binding site [chemical binding]; other site
1163389000071	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
1163389000072	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1163389000073	homodimer interface [polypeptide binding]; other site
1163389000074	substrate-cofactor binding pocket; other site
1163389000075	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389000076	catalytic residue [active]
1163389000077	pyruvate phosphate dikinase; Provisional; Region: PRK09279
1163389000078	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1163389000079	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1163389000080	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1163389000081	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1163389000082	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1163389000083	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1163389000084	catalytic site [active]
1163389000085	putative active site [active]
1163389000086	putative substrate binding site [chemical binding]; other site
1163389000087	dimer interface [polypeptide binding]; other site
1163389000088	elongation factor P; Validated; Region: PRK00529
1163389000089	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1163389000090	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1163389000091	RNA binding site [nucleotide binding]; other site
1163389000092	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1163389000093	RNA binding site [nucleotide binding]; other site
1163389000094	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
1163389000095	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1163389000096	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1163389000097	putative acyl-acceptor binding pocket; other site
1163389000098	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1163389000099	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1163389000100	putative acyl-acceptor binding pocket; other site
1163389000101	membrane protein insertase; Provisional; Region: PRK01318
1163389000102	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1163389000103	Ribonuclease P; Region: Ribonuclease_P; pfam00825
1163389000104	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1163389000105	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1163389000106	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1163389000107	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1163389000108	shikimate binding site; other site
1163389000109	NAD(P) binding site [chemical binding]; other site
1163389000110	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1163389000111	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1163389000112	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1163389000113	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1163389000114	Predicted methyltransferases [General function prediction only]; Region: COG0313
1163389000115	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1163389000116	putative SAM binding site [chemical binding]; other site
1163389000117	putative homodimer interface [polypeptide binding]; other site
1163389000118	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1163389000119	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1163389000120	active site
1163389000121	motif I; other site
1163389000122	motif II; other site
1163389000123	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1163389000124	Ligand Binding Site [chemical binding]; other site
1163389000125	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1163389000126	Ligand Binding Site [chemical binding]; other site
1163389000127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389000128	putative substrate translocation pore; other site
1163389000129	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1163389000130	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1163389000131	LamB/YcsF family protein; Provisional; Region: PRK05406
1163389000132	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
1163389000133	Sulfatase; Region: Sulfatase; cl17466
1163389000134	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
1163389000135	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1163389000136	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1163389000137	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1163389000138	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
1163389000139	putative FMN binding site [chemical binding]; other site
1163389000140	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1163389000141	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1163389000142	aromatic amino acid transport protein; Region: araaP; TIGR00837
1163389000143	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1163389000144	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1163389000145	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1163389000146	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1163389000147	catalytic residue [active]
1163389000148	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1163389000149	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1163389000150	putative effector binding pocket; other site
1163389000151	dimerization interface [polypeptide binding]; other site
1163389000152	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1163389000153	dimer interface [polypeptide binding]; other site
1163389000154	active site
1163389000155	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1163389000156	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268
1163389000157	trimer interface [polypeptide binding]; other site
1163389000158	putative substrate binding pocket [chemical binding]; other site
1163389000159	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1163389000160	GTP-binding protein LepA; Provisional; Region: PRK05433
1163389000161	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1163389000162	G1 box; other site
1163389000163	putative GEF interaction site [polypeptide binding]; other site
1163389000164	GTP/Mg2+ binding site [chemical binding]; other site
1163389000165	Switch I region; other site
1163389000166	G2 box; other site
1163389000167	G3 box; other site
1163389000168	Switch II region; other site
1163389000169	G4 box; other site
1163389000170	G5 box; other site
1163389000171	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1163389000172	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1163389000173	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1163389000174	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1163389000175	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1163389000176	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1163389000177	active site
1163389000178	catalytic residues [active]
1163389000179	metal binding site [ion binding]; metal-binding site
1163389000180	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1163389000181	homopentamer interface [polypeptide binding]; other site
1163389000182	active site
1163389000183	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1163389000184	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1163389000185	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1163389000186	dimerization interface [polypeptide binding]; other site
1163389000187	active site
1163389000188	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1163389000189	Lumazine binding domain; Region: Lum_binding; pfam00677
1163389000190	Lumazine binding domain; Region: Lum_binding; pfam00677
1163389000191	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1163389000192	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1163389000193	catalytic motif [active]
1163389000194	Zn binding site [ion binding]; other site
1163389000195	RibD C-terminal domain; Region: RibD_C; pfam01872
1163389000196	potential frameshift: common BLAST hit: gi|118496730|ref|YP_897780.1| Na+/H+ antiporter
1163389000197	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1163389000198	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1163389000199	dimer interface [polypeptide binding]; other site
1163389000200	[2Fe-2S] cluster binding site [ion binding]; other site
1163389000201	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1163389000202	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1163389000203	tandem repeat interface [polypeptide binding]; other site
1163389000204	oligomer interface [polypeptide binding]; other site
1163389000205	active site residues [active]
1163389000206	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
1163389000207	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1163389000208	preprotein translocase subunit SecB; Provisional; Region: PRK13031
1163389000209	SecA binding site; other site
1163389000210	Preprotein binding site; other site
1163389000211	recombinase A; Provisional; Region: recA; PRK09354
1163389000212	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1163389000213	hexamer interface [polypeptide binding]; other site
1163389000214	Walker A motif; other site
1163389000215	ATP binding site [chemical binding]; other site
1163389000216	Walker B motif; other site
1163389000217	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1163389000218	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1163389000219	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1163389000220	dimer interface [polypeptide binding]; other site
1163389000221	ssDNA binding site [nucleotide binding]; other site
1163389000222	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1163389000223	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1163389000224	propionate/acetate kinase; Provisional; Region: PRK12379
1163389000225	phosphate acetyltransferase; Reviewed; Region: PRK05632
1163389000226	DRTGG domain; Region: DRTGG; pfam07085
1163389000227	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1163389000228	succinic semialdehyde dehydrogenase; Region: PLN02278
1163389000229	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1163389000230	tetramerization interface [polypeptide binding]; other site
1163389000231	NAD(P) binding site [chemical binding]; other site
1163389000232	catalytic residues [active]
1163389000233	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
1163389000234	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1163389000235	Coenzyme A binding pocket [chemical binding]; other site
1163389000236	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1163389000237	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
1163389000238	putative active site [active]
1163389000239	catalytic triad [active]
1163389000240	putative dimer interface [polypeptide binding]; other site
1163389000241	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1163389000242	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1163389000243	dimer interface [polypeptide binding]; other site
1163389000244	anticodon binding site; other site
1163389000245	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1163389000246	homodimer interface [polypeptide binding]; other site
1163389000247	motif 1; other site
1163389000248	active site
1163389000249	motif 2; other site
1163389000250	GAD domain; Region: GAD; pfam02938
1163389000251	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1163389000252	active site
1163389000253	motif 3; other site
1163389000254	Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774
1163389000255	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
1163389000256	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
1163389000257	RNB domain; Region: RNB; pfam00773
1163389000258	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
1163389000259	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1163389000260	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1163389000261	domain interfaces; other site
1163389000262	active site
1163389000263	camphor resistance protein CrcB; Provisional; Region: PRK14226
1163389000264	Zinc-finger domain; Region: zf-CHCC; cl01821
1163389000265	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
1163389000266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1163389000267	dimer interface [polypeptide binding]; other site
1163389000268	conserved gate region; other site
1163389000269	putative PBP binding loops; other site
1163389000270	ABC-ATPase subunit interface; other site
1163389000271	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1163389000272	dimer interface [polypeptide binding]; other site
1163389000273	conserved gate region; other site
1163389000274	putative PBP binding loops; other site
1163389000275	ABC-ATPase subunit interface; other site
1163389000276	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1163389000277	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1163389000278	Walker A/P-loop; other site
1163389000279	ATP binding site [chemical binding]; other site
1163389000280	Q-loop/lid; other site
1163389000281	ABC transporter signature motif; other site
1163389000282	Walker B; other site
1163389000283	D-loop; other site
1163389000284	H-loop/switch region; other site
1163389000285	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
1163389000286	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1163389000287	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1163389000288	TrkA-N domain; Region: TrkA_N; pfam02254
1163389000289	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1163389000290	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1163389000291	trimer interface [polypeptide binding]; other site
1163389000292	putative metal binding site [ion binding]; other site
1163389000293	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
1163389000294	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
1163389000295	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1163389000296	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231
1163389000297	putative active site [active]
1163389000298	Zn binding site [ion binding]; other site
1163389000299	YGGT family; Region: YGGT; pfam02325
1163389000300	YGGT family; Region: YGGT; pfam02325
1163389000301	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1163389000302	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1163389000303	Walker A/P-loop; other site
1163389000304	ATP binding site [chemical binding]; other site
1163389000305	Q-loop/lid; other site
1163389000306	ABC transporter signature motif; other site
1163389000307	Walker B; other site
1163389000308	D-loop; other site
1163389000309	H-loop/switch region; other site
1163389000310	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
1163389000311	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
1163389000312	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1163389000313	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1163389000314	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1163389000315	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
1163389000316	putative acyl-acceptor binding pocket; other site
1163389000317	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1163389000318	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1163389000319	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1163389000320	RNA binding site [nucleotide binding]; other site
1163389000321	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1163389000322	RNA binding site [nucleotide binding]; other site
1163389000323	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1163389000324	RNA binding site [nucleotide binding]; other site
1163389000325	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1163389000326	RNA binding site [nucleotide binding]; other site
1163389000327	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1163389000328	RNA binding site [nucleotide binding]; other site
1163389000329	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
1163389000330	RNA binding site [nucleotide binding]; other site
1163389000331	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1163389000332	nucleoside/Zn binding site; other site
1163389000333	dimer interface [polypeptide binding]; other site
1163389000334	catalytic motif [active]
1163389000335	D-alanyl-alanine synthetase A; Provisional; Region: PRK14569
1163389000336	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1163389000337	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1163389000338	Cell division protein FtsQ; Region: FtsQ; pfam03799
1163389000339	cell division protein FtsA; Region: ftsA; TIGR01174
1163389000340	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1163389000341	nucleotide binding site [chemical binding]; other site
1163389000342	Cell division protein FtsA; Region: FtsA; pfam14450
1163389000343	cell division protein FtsZ; Validated; Region: PRK09330
1163389000344	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1163389000345	nucleotide binding site [chemical binding]; other site
1163389000346	SulA interaction site; other site
1163389000347	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1163389000348	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1163389000349	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1163389000350	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1163389000351	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957
1163389000352	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1163389000353	Walker A motif; other site
1163389000354	ATP binding site [chemical binding]; other site
1163389000355	Walker B motif; other site
1163389000356	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1163389000357	arginine finger; other site
1163389000358	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1163389000359	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1163389000360	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1163389000361	RF-1 domain; Region: RF-1; pfam00472
1163389000362	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1163389000363	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1163389000364	dimer interface [polypeptide binding]; other site
1163389000365	putative anticodon binding site; other site
1163389000366	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1163389000367	motif 1; other site
1163389000368	active site
1163389000369	motif 2; other site
1163389000370	motif 3; other site
1163389000371	hypothetical protein; Provisional; Region: PRK05208
1163389000372	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1163389000373	Glutaminase; Region: Glutaminase; cl00907
1163389000374	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1163389000375	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1163389000376	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1163389000377	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1163389000378	glutamine synthetase; Region: PLN02284
1163389000379	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1163389000380	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1163389000381	DNA polymerase III, delta subunit; Region: holA; TIGR01128
1163389000382	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1163389000383	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1163389000384	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1163389000385	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1163389000386	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1163389000387	purine monophosphate binding site [chemical binding]; other site
1163389000388	dimer interface [polypeptide binding]; other site
1163389000389	putative catalytic residues [active]
1163389000390	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1163389000391	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1163389000392	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1163389000393	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1163389000394	GDP-binding site [chemical binding]; other site
1163389000395	ACT binding site; other site
1163389000396	IMP binding site; other site
1163389000397	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1163389000398	active site
1163389000399	Dienelactone hydrolase family; Region: DLH; pfam01738
1163389000400	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1163389000401	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1163389000402	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1163389000403	Walker A/P-loop; other site
1163389000404	ATP binding site [chemical binding]; other site
1163389000405	Q-loop/lid; other site
1163389000406	ABC transporter signature motif; other site
1163389000407	Walker B; other site
1163389000408	D-loop; other site
1163389000409	H-loop/switch region; other site
1163389000410	potential frameshift: common BLAST hit: gi|167626862|ref|YP_001677362.1| manganese/zinc/iron chelate uptake transporter family protein
1163389000411	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1163389000412	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1163389000413	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1163389000414	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1163389000415	intersubunit interface [polypeptide binding]; other site
1163389000416	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389000417	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1163389000418	putative substrate translocation pore; other site
1163389000419	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
1163389000420	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1163389000421	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1163389000422	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1163389000423	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1163389000424	primosome assembly protein PriA; Validated; Region: PRK05580
1163389000425	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1163389000426	ATP binding site [chemical binding]; other site
1163389000427	putative Mg++ binding site [ion binding]; other site
1163389000428	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1163389000429	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1163389000430	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1163389000431	substrate binding pocket [chemical binding]; other site
1163389000432	membrane-bound complex binding site; other site
1163389000433	hinge residues; other site
1163389000434	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1163389000435	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1163389000436	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1163389000437	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
1163389000438	TIGR01210 family protein; Region: TIGR01210
1163389000439	pyridoxamine kinase; Validated; Region: PRK05756
1163389000440	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1163389000441	dimer interface [polypeptide binding]; other site
1163389000442	pyridoxal binding site [chemical binding]; other site
1163389000443	ATP binding site [chemical binding]; other site
1163389000444	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
1163389000445	MoxR-like ATPases [General function prediction only]; Region: COG0714
1163389000446	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
1163389000447	Walker A motif; other site
1163389000448	ATP binding site [chemical binding]; other site
1163389000449	Walker B motif; other site
1163389000450	arginine finger; other site
1163389000451	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1163389000452	Protein of unknown function DUF58; Region: DUF58; pfam01882
1163389000453	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
1163389000454	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
1163389000455	metal ion-dependent adhesion site (MIDAS); other site
1163389000456	von Willebrand factor type A domain; Region: VWA_2; pfam13519
1163389000457	metal ion-dependent adhesion site (MIDAS); other site
1163389000458	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1163389000459	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1163389000460	TPR motif; other site
1163389000461	binding surface
1163389000462	Oxygen tolerance; Region: BatD; pfam13584
1163389000463	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
1163389000464	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1163389000465	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1163389000466	HIGH motif; other site
1163389000467	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1163389000468	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1163389000469	active site
1163389000470	KMSKS motif; other site
1163389000471	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1163389000472	tRNA binding surface [nucleotide binding]; other site
1163389000473	anticodon binding site; other site
1163389000474	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1163389000475	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
1163389000476	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
1163389000477	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
1163389000478	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1163389000479	nudix motif; other site
1163389000480	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1163389000481	substrate binding site [chemical binding]; other site
1163389000482	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1163389000483	active site
1163389000484	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cl00533
1163389000485	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1163389000486	alpha-gamma subunit interface [polypeptide binding]; other site
1163389000487	beta-gamma subunit interface [polypeptide binding]; other site
1163389000488	UreD urease accessory protein; Region: UreD; cl00530
1163389000489	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
1163389000490	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1163389000491	phosphate binding site [ion binding]; other site
1163389000492	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1163389000493	dimer interface [polypeptide binding]; other site
1163389000494	FMN binding site [chemical binding]; other site
1163389000495	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1163389000496	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1163389000497	HIGH motif; other site
1163389000498	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1163389000499	active site
1163389000500	KMSKS motif; other site
1163389000501	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1163389000502	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1163389000503	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1163389000504	folate binding site [chemical binding]; other site
1163389000505	NADP+ binding site [chemical binding]; other site
1163389000506	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1163389000507	rRNA interaction site [nucleotide binding]; other site
1163389000508	S8 interaction site; other site
1163389000509	putative laminin-1 binding site; other site
1163389000510	elongation factor Ts; Provisional; Region: tsf; PRK09377
1163389000511	UBA/TS-N domain; Region: UBA; pfam00627
1163389000512	Elongation factor TS; Region: EF_TS; pfam00889
1163389000513	Elongation factor TS; Region: EF_TS; pfam00889
1163389000514	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1163389000515	putative nucleotide binding site [chemical binding]; other site
1163389000516	uridine monophosphate binding site [chemical binding]; other site
1163389000517	homohexameric interface [polypeptide binding]; other site
1163389000518	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1163389000519	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1163389000520	hinge region; other site
1163389000521	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836
1163389000522	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1163389000523	catalytic residue [active]
1163389000524	putative FPP diphosphate  binding site; other site
1163389000525	putative FPP binding hydrophobic cleft; other site
1163389000526	dimer interface [polypeptide binding]; other site
1163389000527	putative IPP diphosphate binding site; other site
1163389000528	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
1163389000529	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1163389000530	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1163389000531	trimer interface [polypeptide binding]; other site
1163389000532	active site
1163389000533	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1163389000534	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1163389000535	S17 interaction site [polypeptide binding]; other site
1163389000536	S8 interaction site; other site
1163389000537	16S rRNA interaction site [nucleotide binding]; other site
1163389000538	streptomycin interaction site [chemical binding]; other site
1163389000539	23S rRNA interaction site [nucleotide binding]; other site
1163389000540	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1163389000541	30S ribosomal protein S7; Validated; Region: PRK05302
1163389000542	elongation factor G; Reviewed; Region: PRK00007
1163389000543	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1163389000544	G1 box; other site
1163389000545	putative GEF interaction site [polypeptide binding]; other site
1163389000546	GTP/Mg2+ binding site [chemical binding]; other site
1163389000547	Switch I region; other site
1163389000548	G2 box; other site
1163389000549	G3 box; other site
1163389000550	Switch II region; other site
1163389000551	G4 box; other site
1163389000552	G5 box; other site
1163389000553	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1163389000554	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1163389000555	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1163389000556	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1163389000557	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1163389000558	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1163389000559	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1163389000560	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1163389000561	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1163389000562	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1163389000563	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1163389000564	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1163389000565	putative translocon binding site; other site
1163389000566	protein-rRNA interface [nucleotide binding]; other site
1163389000567	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1163389000568	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1163389000569	G-X-X-G motif; other site
1163389000570	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1163389000571	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1163389000572	23S rRNA interface [nucleotide binding]; other site
1163389000573	5S rRNA interface [nucleotide binding]; other site
1163389000574	putative antibiotic binding site [chemical binding]; other site
1163389000575	L25 interface [polypeptide binding]; other site
1163389000576	L27 interface [polypeptide binding]; other site
1163389000577	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1163389000578	23S rRNA interface [nucleotide binding]; other site
1163389000579	putative translocon interaction site; other site
1163389000580	signal recognition particle (SRP54) interaction site; other site
1163389000581	L23 interface [polypeptide binding]; other site
1163389000582	trigger factor interaction site; other site
1163389000583	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1163389000584	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1163389000585	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1163389000586	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1163389000587	RNA binding site [nucleotide binding]; other site
1163389000588	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1163389000589	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1163389000590	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1163389000591	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1163389000592	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1163389000593	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1163389000594	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1163389000595	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1163389000596	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1163389000597	23S rRNA interface [nucleotide binding]; other site
1163389000598	L21e interface [polypeptide binding]; other site
1163389000599	5S rRNA interface [nucleotide binding]; other site
1163389000600	L27 interface [polypeptide binding]; other site
1163389000601	L5 interface [polypeptide binding]; other site
1163389000602	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1163389000603	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1163389000604	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1163389000605	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1163389000606	23S rRNA binding site [nucleotide binding]; other site
1163389000607	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1163389000608	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1163389000609	SecY translocase; Region: SecY; pfam00344
1163389000610	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1163389000611	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1163389000612	30S ribosomal protein S11; Validated; Region: PRK05309
1163389000613	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1163389000614	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1163389000615	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1163389000616	RNA binding surface [nucleotide binding]; other site
1163389000617	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1163389000618	alphaNTD homodimer interface [polypeptide binding]; other site
1163389000619	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1163389000620	alphaNTD - beta interaction site [polypeptide binding]; other site
1163389000621	alphaNTD - beta' interaction site [polypeptide binding]; other site
1163389000622	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1163389000623	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1163389000624	Ion channel; Region: Ion_trans_2; pfam07885
1163389000625	heat shock protein 90; Provisional; Region: PRK05218
1163389000626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1163389000627	ATP binding site [chemical binding]; other site
1163389000628	Mg2+ binding site [ion binding]; other site
1163389000629	G-X-G motif; other site
1163389000630	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1163389000631	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1163389000632	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1163389000633	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1163389000634	nucleotide binding site [chemical binding]; other site
1163389000635	N-acetyl-L-glutamate binding site [chemical binding]; other site
1163389000636	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1163389000637	heterotetramer interface [polypeptide binding]; other site
1163389000638	active site pocket [active]
1163389000639	cleavage site
1163389000640	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1163389000641	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1163389000642	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
1163389000643	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1163389000644	inhibitor-cofactor binding pocket; inhibition site
1163389000645	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389000646	catalytic residue [active]
1163389000647	Arginine repressor [Transcription]; Region: ArgR; COG1438
1163389000648	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1163389000649	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1163389000650	Lyase; Region: Lyase_1; pfam00206
1163389000651	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1163389000652	tetramer interface [polypeptide binding]; other site
1163389000653	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1163389000654	argininosuccinate synthase; Provisional; Region: PRK13820
1163389000655	ANP binding site [chemical binding]; other site
1163389000656	Substrate Binding Site II [chemical binding]; other site
1163389000657	Substrate Binding Site I [chemical binding]; other site
1163389000658	hypothetical protein; Provisional; Region: PRK11588
1163389000659	CTP synthetase; Validated; Region: pyrG; PRK05380
1163389000660	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1163389000661	Catalytic site [active]
1163389000662	active site
1163389000663	UTP binding site [chemical binding]; other site
1163389000664	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1163389000665	active site
1163389000666	putative oxyanion hole; other site
1163389000667	catalytic triad [active]
1163389000668	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1163389000669	active site
1163389000670	multimer interface [polypeptide binding]; other site
1163389000671	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1163389000672	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1163389000673	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1163389000674	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1163389000675	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1163389000676	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1163389000677	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1163389000678	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
1163389000679	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1163389000680	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1163389000681	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1163389000682	FAD binding pocket [chemical binding]; other site
1163389000683	FAD binding motif [chemical binding]; other site
1163389000684	phosphate binding motif [ion binding]; other site
1163389000685	beta-alpha-beta structure motif; other site
1163389000686	NAD binding pocket [chemical binding]; other site
1163389000687	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325
1163389000688	SnoaL-like domain; Region: SnoaL_2; pfam12680
1163389000689	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
1163389000690	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1163389000691	ProQ/FINO family; Region: ProQ; pfam04352
1163389000692	Cation transport protein; Region: TrkH; cl17365
1163389000693	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1163389000694	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
1163389000695	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
1163389000696	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1163389000697	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1163389000698	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1163389000699	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
1163389000700	active site
1163389000701	lysine transporter; Provisional; Region: PRK10836
1163389000702	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1163389000703	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1163389000704	putative active site [active]
1163389000705	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1163389000706	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1163389000707	Na binding site [ion binding]; other site
1163389000708	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1163389000709	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1163389000710	DXD motif; other site
1163389000711	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1163389000712	Domain of unknown function DUF21; Region: DUF21; pfam01595
1163389000713	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1163389000714	Transporter associated domain; Region: CorC_HlyC; cl08393
1163389000715	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1163389000716	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1163389000717	active site
1163389000718	HIGH motif; other site
1163389000719	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1163389000720	KMSKS motif; other site
1163389000721	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1163389000722	tRNA binding surface [nucleotide binding]; other site
1163389000723	anticodon binding site; other site
1163389000724	HemK family putative methylases; Region: hemK_fam; TIGR00536
1163389000725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1163389000726	S-adenosylmethionine binding site [chemical binding]; other site
1163389000727	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1163389000728	Coenzyme A binding pocket [chemical binding]; other site
1163389000729	potential frameshift: common BLAST hit: gi|167626731|ref|YP_001677231.1| chitinase
1163389000730	potential frameshift: common BLAST hit: gi|167626731|ref|YP_001677231.1| chitinase
1163389000731	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
1163389000732	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1163389000733	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1163389000734	catalytic residue [active]
1163389000735	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1163389000736	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1163389000737	catalytic residue [active]
1163389000738	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1163389000739	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1163389000740	VacJ like lipoprotein; Region: VacJ; cl01073
1163389000741	BolA-like protein; Region: BolA; cl00386
1163389000742	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1163389000743	anti sigma factor interaction site; other site
1163389000744	regulatory phosphorylation site [posttranslational modification]; other site
1163389000745	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
1163389000746	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1163389000747	mce related protein; Region: MCE; pfam02470
1163389000748	Permease; Region: Permease; pfam02405
1163389000749	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1163389000750	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1163389000751	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1163389000752	Walker A/P-loop; other site
1163389000753	ATP binding site [chemical binding]; other site
1163389000754	Q-loop/lid; other site
1163389000755	ABC transporter signature motif; other site
1163389000756	Walker B; other site
1163389000757	D-loop; other site
1163389000758	H-loop/switch region; other site
1163389000759	cell division topological specificity factor MinE; Provisional; Region: PRK13990
1163389000760	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1163389000761	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1163389000762	Switch I; other site
1163389000763	Switch II; other site
1163389000764	septum formation inhibitor; Reviewed; Region: minC; PRK04804
1163389000765	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
1163389000766	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1163389000767	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1163389000768	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1163389000769	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627
1163389000770	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1163389000771	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1163389000772	ssDNA binding site; other site
1163389000773	generic binding surface II; other site
1163389000774	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1163389000775	ATP binding site [chemical binding]; other site
1163389000776	putative Mg++ binding site [ion binding]; other site
1163389000777	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1163389000778	nucleotide binding region [chemical binding]; other site
1163389000779	ATP-binding site [chemical binding]; other site
1163389000780	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1163389000781	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1163389000782	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1163389000783	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1163389000784	nudix motif; other site
1163389000785	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
1163389000786	ArsC family; Region: ArsC; pfam03960
1163389000787	catalytic residue [active]
1163389000788	hypothetical protein; Validated; Region: PRK09039
1163389000789	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
1163389000790	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
1163389000791	TrkA-C domain; Region: TrkA_C; pfam02080
1163389000792	TrkA-C domain; Region: TrkA_C; pfam02080
1163389000793	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1163389000794	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
1163389000795	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1163389000796	ligand binding site [chemical binding]; other site
1163389000797	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1163389000798	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1163389000799	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1163389000800	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1163389000801	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
1163389000802	homotrimer interaction site [polypeptide binding]; other site
1163389000803	active site
1163389000804	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1163389000805	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1163389000806	TolQ protein; Region: tolQ; TIGR02796
1163389000807	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1163389000808	TolR protein; Region: tolR; TIGR02801
1163389000809	Gram-negative bacterial tonB protein; Region: TonB; cl10048
1163389000810	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
1163389000811	TolB amino-terminal domain; Region: TolB_N; pfam04052
1163389000812	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1163389000813	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1163389000814	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1163389000815	ligand binding site [chemical binding]; other site
1163389000816	potential frameshift: common BLAST hit: gi|118496968|ref|YP_898018.1| ribosomal protein S12 methylthiotransferase
1163389000817	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1163389000818	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1163389000819	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1163389000820	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
1163389000821	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
1163389000822	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1163389000823	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1163389000824	YheO-like PAS domain; Region: PAS_6; pfam08348
1163389000825	HTH domain; Region: HTH_22; pfam13309
1163389000826	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1163389000827	hypothetical protein; Provisional; Region: PRK10621
1163389000828	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1163389000829	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1163389000830	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1163389000831	Predicted acetyltransferase [General function prediction only]; Region: COG5628
1163389000832	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1163389000833	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1163389000834	Coenzyme A binding pocket [chemical binding]; other site
1163389000835	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1163389000836	hypothetical protein; Validated; Region: PRK00029
1163389000837	hypothetical protein; Validated; Region: PRK00029
1163389000838	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
1163389000839	putative DNA binding helix; other site
1163389000840	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
1163389000841	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1163389000842	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1163389000843	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
1163389000844	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1163389000845	thiamine phosphate binding site [chemical binding]; other site
1163389000846	active site
1163389000847	pyrophosphate binding site [ion binding]; other site
1163389000848	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1163389000849	substrate binding site [chemical binding]; other site
1163389000850	multimerization interface [polypeptide binding]; other site
1163389000851	ATP binding site [chemical binding]; other site
1163389000852	thiamine monophosphate kinase; Provisional; Region: PRK05731
1163389000853	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1163389000854	ATP binding site [chemical binding]; other site
1163389000855	dimerization interface [polypeptide binding]; other site
1163389000856	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1163389000857	substrate binding site [chemical binding]; other site
1163389000858	dimer interface [polypeptide binding]; other site
1163389000859	ATP binding site [chemical binding]; other site
1163389000860	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
1163389000861	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1163389000862	non-specific DNA binding site [nucleotide binding]; other site
1163389000863	salt bridge; other site
1163389000864	sequence-specific DNA binding site [nucleotide binding]; other site
1163389000865	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
1163389000866	Protein of unknown function (DUF423); Region: DUF423; cl01008
1163389000867	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847
1163389000868	UbiA prenyltransferase family; Region: UbiA; pfam01040
1163389000869	Chorismate lyase; Region: Chor_lyase; cl01230
1163389000870	ribonuclease PH; Reviewed; Region: rph; PRK00173
1163389000871	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1163389000872	hexamer interface [polypeptide binding]; other site
1163389000873	active site
1163389000874	heat shock protein HtpX; Provisional; Region: PRK02870
1163389000875	LemA family; Region: LemA; cl00742
1163389000876	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
1163389000877	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1163389000878	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1163389000879	putative dimerization interface [polypeptide binding]; other site
1163389000880	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1163389000881	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1163389000882	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1163389000883	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1163389000884	putative DNA binding site [nucleotide binding]; other site
1163389000885	dimerization interface [polypeptide binding]; other site
1163389000886	putative Zn2+ binding site [ion binding]; other site
1163389000887	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1163389000888	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1163389000889	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1163389000890	Colicin V production protein; Region: Colicin_V; pfam02674
1163389000891	DNA repair protein RadA; Provisional; Region: PRK11823
1163389000892	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1163389000893	Walker A motif/ATP binding site; other site
1163389000894	ATP binding site [chemical binding]; other site
1163389000895	Walker B motif; other site
1163389000896	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1163389000897	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1163389000898	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1163389000899	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1163389000900	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1163389000901	Tetramer interface [polypeptide binding]; other site
1163389000902	active site
1163389000903	FMN-binding site [chemical binding]; other site
1163389000904	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1163389000905	SelR domain; Region: SelR; pfam01641
1163389000906	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1163389000907	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1163389000908	E-class dimer interface [polypeptide binding]; other site
1163389000909	P-class dimer interface [polypeptide binding]; other site
1163389000910	active site
1163389000911	Cu2+ binding site [ion binding]; other site
1163389000912	Zn2+ binding site [ion binding]; other site
1163389000913	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1163389000914	Cupin domain; Region: Cupin_2; cl17218
1163389000915	aspartate aminotransferase; Provisional; Region: PRK07568
1163389000916	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1163389000917	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389000918	homodimer interface [polypeptide binding]; other site
1163389000919	catalytic residue [active]
1163389000920	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1163389000921	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1163389000922	Walker A/P-loop; other site
1163389000923	ATP binding site [chemical binding]; other site
1163389000924	Q-loop/lid; other site
1163389000925	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1163389000926	ABC transporter signature motif; other site
1163389000927	Walker B; other site
1163389000928	D-loop; other site
1163389000929	H-loop/switch region; other site
1163389000930	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
1163389000931	Pilin (bacterial filament); Region: Pilin; pfam00114
1163389000932	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1163389000933	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
1163389000934	active site
1163389000935	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180
1163389000936	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1163389000937	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1163389000938	homodimer interface [polypeptide binding]; other site
1163389000939	NADP binding site [chemical binding]; other site
1163389000940	substrate binding site [chemical binding]; other site
1163389000941	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1163389000942	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1163389000943	dimerization interface [polypeptide binding]; other site
1163389000944	putative ATP binding site [chemical binding]; other site
1163389000945	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1163389000946	active site
1163389000947	ATP binding site [chemical binding]; other site
1163389000948	substrate binding site [chemical binding]; other site
1163389000949	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1163389000950	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1163389000951	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1163389000952	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1163389000953	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1163389000954	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1163389000955	active site
1163389000956	substrate binding site [chemical binding]; other site
1163389000957	cosubstrate binding site; other site
1163389000958	catalytic site [active]
1163389000959	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1163389000960	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1163389000961	ATP-grasp domain; Region: ATP-grasp; pfam02222
1163389000962	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
1163389000963	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1163389000964	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1163389000965	active site
1163389000966	Zn binding site [ion binding]; other site
1163389000967	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
1163389000968	DNA topoisomerase I; Validated; Region: PRK06599
1163389000969	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1163389000970	active site
1163389000971	interdomain interaction site; other site
1163389000972	putative metal-binding site [ion binding]; other site
1163389000973	nucleotide binding site [chemical binding]; other site
1163389000974	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1163389000975	domain I; other site
1163389000976	DNA binding groove [nucleotide binding]
1163389000977	phosphate binding site [ion binding]; other site
1163389000978	domain II; other site
1163389000979	domain III; other site
1163389000980	nucleotide binding site [chemical binding]; other site
1163389000981	catalytic site [active]
1163389000982	domain IV; other site
1163389000983	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1163389000984	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1163389000985	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1163389000986	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1163389000987	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1163389000988	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1163389000989	P-loop; other site
1163389000990	Magnesium ion binding site [ion binding]; other site
1163389000991	ParB-like nuclease domain; Region: ParB; smart00470
1163389000992	KorB domain; Region: KorB; pfam08535
1163389000993	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1163389000994	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1163389000995	catalytic triad [active]
1163389000996	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
1163389000997	active site
1163389000998	catalytic triad [active]
1163389000999	oxyanion hole [active]
1163389001000	FtsJ-like methyltransferase; Region: FtsJ; cl17430
1163389001001	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1163389001002	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1163389001003	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1163389001004	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1163389001005	active site
1163389001006	HIGH motif; other site
1163389001007	nucleotide binding site [chemical binding]; other site
1163389001008	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1163389001009	active site
1163389001010	KMSKS motif; other site
1163389001011	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1163389001012	tRNA binding surface [nucleotide binding]; other site
1163389001013	anticodon binding site; other site
1163389001014	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1163389001015	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1163389001016	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1163389001017	active site
1163389001018	Riboflavin kinase; Region: Flavokinase; pfam01687
1163389001019	malate dehydrogenase; Provisional; Region: PRK13529
1163389001020	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1163389001021	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1163389001022	NAD(P) binding pocket [chemical binding]; other site
1163389001023	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
1163389001024	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
1163389001025	GTP-binding protein Der; Reviewed; Region: PRK00093
1163389001026	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1163389001027	G1 box; other site
1163389001028	GTP/Mg2+ binding site [chemical binding]; other site
1163389001029	Switch I region; other site
1163389001030	G2 box; other site
1163389001031	Switch II region; other site
1163389001032	G3 box; other site
1163389001033	G4 box; other site
1163389001034	G5 box; other site
1163389001035	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1163389001036	G1 box; other site
1163389001037	GTP/Mg2+ binding site [chemical binding]; other site
1163389001038	Switch I region; other site
1163389001039	G2 box; other site
1163389001040	G3 box; other site
1163389001041	Switch II region; other site
1163389001042	G4 box; other site
1163389001043	G5 box; other site
1163389001044	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1163389001045	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
1163389001046	putative active site [active]
1163389001047	UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812
1163389001048	FAD binding domain; Region: FAD_binding_4; pfam01565
1163389001049	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1163389001050	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1163389001051	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1163389001052	nucleotide binding site/active site [active]
1163389001053	HIT family signature motif; other site
1163389001054	catalytic residue [active]
1163389001055	ABC1 family; Region: ABC1; cl17513
1163389001056	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1163389001057	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
1163389001058	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1163389001059	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1163389001060	S-adenosylmethionine binding site [chemical binding]; other site
1163389001061	Glucokinase; Region: Glucokinase; pfam02685
1163389001062	glucokinase, proteobacterial type; Region: glk; TIGR00749
1163389001063	Intracellular septation protein A; Region: IspA; pfam04279
1163389001064	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1163389001065	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1163389001066	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1163389001067	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
1163389001068	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1163389001069	active site
1163389001070	HIGH motif; other site
1163389001071	KMSKS motif; other site
1163389001072	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1163389001073	tRNA binding surface [nucleotide binding]; other site
1163389001074	anticodon binding site; other site
1163389001075	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1163389001076	dimer interface [polypeptide binding]; other site
1163389001077	putative tRNA-binding site [nucleotide binding]; other site
1163389001078	potential frameshift: common BLAST hit: gi|337754044|ref|YP_004646555.1| dienelactone hydrolase family protein
1163389001079	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1163389001080	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1163389001081	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1163389001082	Serine hydrolase (FSH1); Region: FSH1; pfam03959
1163389001083	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1163389001084	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1163389001085	dimer interface [polypeptide binding]; other site
1163389001086	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389001087	catalytic residue [active]
1163389001088	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1163389001089	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1163389001090	putative Zn2+ binding site [ion binding]; other site
1163389001091	putative DNA binding site [nucleotide binding]; other site
1163389001092	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1163389001093	dimerization interface [polypeptide binding]; other site
1163389001094	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1163389001095	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1163389001096	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1163389001097	G1 box; other site
1163389001098	GTP/Mg2+ binding site [chemical binding]; other site
1163389001099	Switch I region; other site
1163389001100	G2 box; other site
1163389001101	Switch II region; other site
1163389001102	G3 box; other site
1163389001103	G4 box; other site
1163389001104	G5 box; other site
1163389001105	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1163389001106	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1163389001107	30S subunit binding site; other site
1163389001108	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
1163389001109	active site
1163389001110	phosphorylation site [posttranslational modification]
1163389001111	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1163389001112	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1163389001113	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1163389001114	Na binding site [ion binding]; other site
1163389001115	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1163389001116	MarR family; Region: MarR_2; pfam12802
1163389001117	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
1163389001118	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
1163389001119	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1163389001120	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1163389001121	23S rRNA interface [nucleotide binding]; other site
1163389001122	L3 interface [polypeptide binding]; other site
1163389001123	Predicted ATPase [General function prediction only]; Region: COG4637
1163389001124	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1163389001125	ABC transporter signature motif; other site
1163389001126	Walker B; other site
1163389001127	D-loop; other site
1163389001128	H-loop/switch region; other site
1163389001129	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1163389001130	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
1163389001131	MltA specific insert domain; Region: MltA; smart00925
1163389001132	3D domain; Region: 3D; pfam06725
1163389001133	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1163389001134	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1163389001135	dimer interface [polypeptide binding]; other site
1163389001136	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1163389001137	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1163389001138	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1163389001139	nucleotide binding site [chemical binding]; other site
1163389001140	chaperone protein DnaJ; Provisional; Region: PRK10767
1163389001141	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1163389001142	HSP70 interaction site [polypeptide binding]; other site
1163389001143	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1163389001144	substrate binding site [polypeptide binding]; other site
1163389001145	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1163389001146	Zn binding sites [ion binding]; other site
1163389001147	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1163389001148	dimer interface [polypeptide binding]; other site
1163389001149	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1163389001150	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1163389001151	homodimer interface [polypeptide binding]; other site
1163389001152	NAD binding pocket [chemical binding]; other site
1163389001153	ATP binding pocket [chemical binding]; other site
1163389001154	Mg binding site [ion binding]; other site
1163389001155	active-site loop [active]
1163389001156	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1163389001157	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1163389001158	HlyD family secretion protein; Region: HlyD_3; pfam13437
1163389001159	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1163389001160	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389001161	putative substrate translocation pore; other site
1163389001162	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389001163	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
1163389001164	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1163389001165	acyl-activating enzyme (AAE) consensus motif; other site
1163389001166	putative active site [active]
1163389001167	putative AMP binding site [chemical binding]; other site
1163389001168	putative CoA binding site [chemical binding]; other site
1163389001169	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
1163389001170	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389001171	putative substrate translocation pore; other site
1163389001172	POT family; Region: PTR2; cl17359
1163389001173	RNA methyltransferase, RsmE family; Region: TIGR00046
1163389001174	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1163389001175	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1163389001176	mce related protein; Region: MCE; pfam02470
1163389001177	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1163389001178	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1163389001179	Walker A/P-loop; other site
1163389001180	ATP binding site [chemical binding]; other site
1163389001181	Q-loop/lid; other site
1163389001182	ABC transporter signature motif; other site
1163389001183	Walker B; other site
1163389001184	D-loop; other site
1163389001185	H-loop/switch region; other site
1163389001186	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1163389001187	Permease; Region: Permease; pfam02405
1163389001188	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1163389001189	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
1163389001190	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1163389001191	RNA binding surface [nucleotide binding]; other site
1163389001192	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1163389001193	active site
1163389001194	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
1163389001195	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1163389001196	TPR motif; other site
1163389001197	binding surface
1163389001198	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1163389001199	putative protease; Provisional; Region: PRK15452
1163389001200	Peptidase family U32; Region: Peptidase_U32; pfam01136
1163389001201	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1163389001202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1163389001203	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1163389001204	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1163389001205	amidophosphoribosyltransferase; Provisional; Region: PRK09246
1163389001206	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1163389001207	active site
1163389001208	tetramer interface [polypeptide binding]; other site
1163389001209	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1163389001210	active site
1163389001211	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
1163389001212	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1163389001213	dimerization interface [polypeptide binding]; other site
1163389001214	ATP binding site [chemical binding]; other site
1163389001215	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1163389001216	dimerization interface [polypeptide binding]; other site
1163389001217	ATP binding site [chemical binding]; other site
1163389001218	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1163389001219	putative active site [active]
1163389001220	catalytic triad [active]
1163389001221	adenylosuccinate lyase; Provisional; Region: PRK07492
1163389001222	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1163389001223	tetramer interface [polypeptide binding]; other site
1163389001224	active site
1163389001225	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1163389001226	E3 interaction surface; other site
1163389001227	lipoyl attachment site [posttranslational modification]; other site
1163389001228	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1163389001229	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1163389001230	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1163389001231	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1163389001232	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1163389001233	GatB domain; Region: GatB_Yqey; smart00845
1163389001234	potential frameshift: common BLAST hit: gi|337754536|ref|YP_004647047.1| Flagellar hook-length control protein FliK
1163389001235	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
1163389001236	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
1163389001237	muropeptide transporter; Validated; Region: ampG; cl17669
1163389001238	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1163389001239	IucA / IucC family; Region: IucA_IucC; pfam04183
1163389001240	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1163389001241	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1163389001242	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1163389001243	catalytic residue [active]
1163389001244	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1163389001245	metal binding site 2 [ion binding]; metal-binding site
1163389001246	putative DNA binding helix; other site
1163389001247	metal binding site 1 [ion binding]; metal-binding site
1163389001248	dimer interface [polypeptide binding]; other site
1163389001249	structural Zn2+ binding site [ion binding]; other site
1163389001250	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
1163389001251	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1163389001252	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
1163389001253	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
1163389001254	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1163389001255	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1163389001256	putative dimer interface [polypeptide binding]; other site
1163389001257	[2Fe-2S] cluster binding site [ion binding]; other site
1163389001258	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1163389001259	SLBB domain; Region: SLBB; pfam10531
1163389001260	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
1163389001261	NADH dehydrogenase subunit G; Validated; Region: PRK09129
1163389001262	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1163389001263	catalytic loop [active]
1163389001264	iron binding site [ion binding]; other site
1163389001265	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1163389001266	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1163389001267	molybdopterin cofactor binding site; other site
1163389001268	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1163389001269	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1163389001270	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1163389001271	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1163389001272	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1163389001273	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
1163389001274	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1163389001275	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1163389001276	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1163389001277	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1163389001278	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1163389001279	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1163389001280	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1163389001281	Membrane fusogenic activity; Region: BMFP; pfam04380
1163389001282	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
1163389001283	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1163389001284	substrate binding site [chemical binding]; other site
1163389001285	active site
1163389001286	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1163389001287	Sm and related proteins; Region: Sm_like; cl00259
1163389001288	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1163389001289	putative oligomer interface [polypeptide binding]; other site
1163389001290	putative RNA binding site [nucleotide binding]; other site
1163389001291	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1163389001292	NusA N-terminal domain; Region: NusA_N; pfam08529
1163389001293	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1163389001294	RNA binding site [nucleotide binding]; other site
1163389001295	homodimer interface [polypeptide binding]; other site
1163389001296	NusA-like KH domain; Region: KH_5; pfam13184
1163389001297	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1163389001298	G-X-X-G motif; other site
1163389001299	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1163389001300	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1163389001301	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1163389001302	translation initiation factor IF-2; Region: IF-2; TIGR00487
1163389001303	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1163389001304	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1163389001305	G1 box; other site
1163389001306	putative GEF interaction site [polypeptide binding]; other site
1163389001307	GTP/Mg2+ binding site [chemical binding]; other site
1163389001308	Switch I region; other site
1163389001309	G2 box; other site
1163389001310	G3 box; other site
1163389001311	Switch II region; other site
1163389001312	G4 box; other site
1163389001313	G5 box; other site
1163389001314	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1163389001315	Translation-initiation factor 2; Region: IF-2; pfam11987
1163389001316	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1163389001317	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1163389001318	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1163389001319	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1163389001320	dimer interface [polypeptide binding]; other site
1163389001321	motif 1; other site
1163389001322	active site
1163389001323	motif 2; other site
1163389001324	motif 3; other site
1163389001325	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1163389001326	anticodon binding site; other site
1163389001327	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389001328	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
1163389001329	putative substrate translocation pore; other site
1163389001330	Predicted ATPase [General function prediction only]; Region: COG1485
1163389001331	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
1163389001332	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1163389001333	RNA binding surface [nucleotide binding]; other site
1163389001334	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1163389001335	active site
1163389001336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389001337	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1163389001338	putative substrate translocation pore; other site
1163389001339	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1163389001340	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1163389001341	F0F1 ATP synthase subunit C; Provisional; Region: PRK13464
1163389001342	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1163389001343	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1163389001344	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1163389001345	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1163389001346	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1163389001347	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1163389001348	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1163389001349	beta subunit interaction interface [polypeptide binding]; other site
1163389001350	Walker A motif; other site
1163389001351	ATP binding site [chemical binding]; other site
1163389001352	Walker B motif; other site
1163389001353	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1163389001354	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1163389001355	core domain interface [polypeptide binding]; other site
1163389001356	delta subunit interface [polypeptide binding]; other site
1163389001357	epsilon subunit interface [polypeptide binding]; other site
1163389001358	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1163389001359	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1163389001360	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1163389001361	alpha subunit interaction interface [polypeptide binding]; other site
1163389001362	Walker A motif; other site
1163389001363	ATP binding site [chemical binding]; other site
1163389001364	Walker B motif; other site
1163389001365	inhibitor binding site; inhibition site
1163389001366	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1163389001367	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452
1163389001368	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1163389001369	gamma subunit interface [polypeptide binding]; other site
1163389001370	epsilon subunit interface [polypeptide binding]; other site
1163389001371	LBP interface [polypeptide binding]; other site
1163389001372	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1163389001373	putative GSH binding site [chemical binding]; other site
1163389001374	catalytic residues [active]
1163389001375	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1163389001376	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1163389001377	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1163389001378	muropeptide transporter; Validated; Region: ampG; cl17669
1163389001379	muropeptide transporter; Reviewed; Region: ampG; PRK11902
1163389001380	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1163389001381	dimer interface [polypeptide binding]; other site
1163389001382	Citrate synthase; Region: Citrate_synt; pfam00285
1163389001383	active site
1163389001384	citrylCoA binding site [chemical binding]; other site
1163389001385	NADH binding [chemical binding]; other site
1163389001386	cationic pore residues; other site
1163389001387	oxalacetate/citrate binding site [chemical binding]; other site
1163389001388	coenzyme A binding site [chemical binding]; other site
1163389001389	catalytic triad [active]
1163389001390	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1163389001391	Iron-sulfur protein interface; other site
1163389001392	proximal quinone binding site [chemical binding]; other site
1163389001393	SdhD (CybS) interface [polypeptide binding]; other site
1163389001394	proximal heme binding site [chemical binding]; other site
1163389001395	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
1163389001396	SdhC subunit interface [polypeptide binding]; other site
1163389001397	proximal heme binding site [chemical binding]; other site
1163389001398	cardiolipin binding site; other site
1163389001399	Iron-sulfur protein interface; other site
1163389001400	proximal quinone binding site [chemical binding]; other site
1163389001401	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
1163389001402	L-aspartate oxidase; Provisional; Region: PRK06175
1163389001403	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1163389001404	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1163389001405	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1163389001406	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1163389001407	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1163389001408	TPP-binding site [chemical binding]; other site
1163389001409	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1163389001410	PYR/PP interface [polypeptide binding]; other site
1163389001411	dimer interface [polypeptide binding]; other site
1163389001412	TPP binding site [chemical binding]; other site
1163389001413	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1163389001414	E3 interaction surface; other site
1163389001415	lipoyl attachment site [posttranslational modification]; other site
1163389001416	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1163389001417	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1163389001418	E3 interaction surface; other site
1163389001419	lipoyl attachment site [posttranslational modification]; other site
1163389001420	e3 binding domain; Region: E3_binding; pfam02817
1163389001421	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1163389001422	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1163389001423	active site
1163389001424	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320
1163389001425	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1163389001426	active site
1163389001427	substrate binding site [chemical binding]; other site
1163389001428	metal binding site [ion binding]; metal-binding site
1163389001429	triosephosphate isomerase; Provisional; Region: PRK14567
1163389001430	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1163389001431	substrate binding site [chemical binding]; other site
1163389001432	dimer interface [polypeptide binding]; other site
1163389001433	catalytic triad [active]
1163389001434	Preprotein translocase SecG subunit; Region: SecG; pfam03840
1163389001435	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
1163389001436	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1163389001437	HemN family oxidoreductase; Provisional; Region: PRK05660
1163389001438	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1163389001439	FeS/SAM binding site; other site
1163389001440	HemN C-terminal domain; Region: HemN_C; pfam06969
1163389001441	GtrA-like protein; Region: GtrA; pfam04138
1163389001442	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
1163389001443	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
1163389001444	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
1163389001445	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1163389001446	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1163389001447	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1163389001448	TIGR01777 family protein; Region: yfcH
1163389001449	NAD(P) binding site [chemical binding]; other site
1163389001450	active site
1163389001451	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1163389001452	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1163389001453	dimer interface [polypeptide binding]; other site
1163389001454	phosphorylation site [posttranslational modification]
1163389001455	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1163389001456	ATP binding site [chemical binding]; other site
1163389001457	Mg2+ binding site [ion binding]; other site
1163389001458	G-X-G motif; other site
1163389001459	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1163389001460	Protein of unknown function (DUF523); Region: DUF523; pfam04463
1163389001461	Uncharacterized conserved protein [Function unknown]; Region: COG3272
1163389001462	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
1163389001463	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
1163389001464	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389001465	putative substrate translocation pore; other site
1163389001466	multidrug efflux protein; Reviewed; Region: PRK09579
1163389001467	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1163389001468	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1163389001469	HlyD family secretion protein; Region: HlyD_3; pfam13437
1163389001470	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
1163389001471	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
1163389001472	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1163389001473	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1163389001474	Walker A/P-loop; other site
1163389001475	ATP binding site [chemical binding]; other site
1163389001476	Q-loop/lid; other site
1163389001477	ABC transporter signature motif; other site
1163389001478	Walker B; other site
1163389001479	D-loop; other site
1163389001480	H-loop/switch region; other site
1163389001481	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1163389001482	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
1163389001483	DNA polymerase I; Provisional; Region: PRK05755
1163389001484	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1163389001485	active site
1163389001486	metal binding site 1 [ion binding]; metal-binding site
1163389001487	putative 5' ssDNA interaction site; other site
1163389001488	metal binding site 3; metal-binding site
1163389001489	metal binding site 2 [ion binding]; metal-binding site
1163389001490	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1163389001491	putative DNA binding site [nucleotide binding]; other site
1163389001492	putative metal binding site [ion binding]; other site
1163389001493	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1163389001494	active site
1163389001495	catalytic site [active]
1163389001496	substrate binding site [chemical binding]; other site
1163389001497	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1163389001498	active site
1163389001499	DNA binding site [nucleotide binding]
1163389001500	catalytic site [active]
1163389001501	pantothenate kinase; Reviewed; Region: PRK13324
1163389001502	phosphopentomutase; Provisional; Region: PRK05362
1163389001503	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1163389001504	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1163389001505	intersubunit interface [polypeptide binding]; other site
1163389001506	active site
1163389001507	catalytic residue [active]
1163389001508	thymidylate kinase; Validated; Region: tmk; PRK00698
1163389001509	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1163389001510	TMP-binding site; other site
1163389001511	ATP-binding site [chemical binding]; other site
1163389001512	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1163389001513	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1163389001514	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
1163389001515	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1163389001516	P loop; other site
1163389001517	GTP binding site [chemical binding]; other site
1163389001518	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
1163389001519	Part of AAA domain; Region: AAA_19; pfam13245
1163389001520	Family description; Region: UvrD_C_2; pfam13538
1163389001521	potential frameshift: common BLAST hit: gi|118498157|ref|YP_899207.1| oligopeptide ABC transporter periplasmic protein
1163389001522	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1163389001523	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1163389001524	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389001525	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1163389001526	putative substrate translocation pore; other site
1163389001527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389001528	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1163389001529	putative substrate translocation pore; other site
1163389001530	glycerol kinase; Provisional; Region: glpK; PRK00047
1163389001531	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1163389001532	N- and C-terminal domain interface [polypeptide binding]; other site
1163389001533	active site
1163389001534	MgATP binding site [chemical binding]; other site
1163389001535	catalytic site [active]
1163389001536	metal binding site [ion binding]; metal-binding site
1163389001537	glycerol binding site [chemical binding]; other site
1163389001538	homotetramer interface [polypeptide binding]; other site
1163389001539	homodimer interface [polypeptide binding]; other site
1163389001540	FBP binding site [chemical binding]; other site
1163389001541	protein IIAGlc interface [polypeptide binding]; other site
1163389001542	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1163389001543	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1163389001544	amphipathic channel; other site
1163389001545	Asn-Pro-Ala signature motifs; other site
1163389001546	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1163389001547	elongation factor Tu; Reviewed; Region: PRK00049
1163389001548	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1163389001549	G1 box; other site
1163389001550	GEF interaction site [polypeptide binding]; other site
1163389001551	GTP/Mg2+ binding site [chemical binding]; other site
1163389001552	Switch I region; other site
1163389001553	G2 box; other site
1163389001554	G3 box; other site
1163389001555	Switch II region; other site
1163389001556	G4 box; other site
1163389001557	G5 box; other site
1163389001558	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1163389001559	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1163389001560	Antibiotic Binding Site [chemical binding]; other site
1163389001561	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
1163389001562	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1163389001563	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1163389001564	putative homodimer interface [polypeptide binding]; other site
1163389001565	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1163389001566	heterodimer interface [polypeptide binding]; other site
1163389001567	homodimer interface [polypeptide binding]; other site
1163389001568	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1163389001569	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1163389001570	23S rRNA interface [nucleotide binding]; other site
1163389001571	L7/L12 interface [polypeptide binding]; other site
1163389001572	putative thiostrepton binding site; other site
1163389001573	L25 interface [polypeptide binding]; other site
1163389001574	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1163389001575	mRNA/rRNA interface [nucleotide binding]; other site
1163389001576	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1163389001577	23S rRNA interface [nucleotide binding]; other site
1163389001578	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1163389001579	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1163389001580	core dimer interface [polypeptide binding]; other site
1163389001581	peripheral dimer interface [polypeptide binding]; other site
1163389001582	L10 interface [polypeptide binding]; other site
1163389001583	L11 interface [polypeptide binding]; other site
1163389001584	putative EF-Tu interaction site [polypeptide binding]; other site
1163389001585	putative EF-G interaction site [polypeptide binding]; other site
1163389001586	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1163389001587	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1163389001588	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1163389001589	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1163389001590	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
1163389001591	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1163389001592	RPB3 interaction site [polypeptide binding]; other site
1163389001593	RPB1 interaction site [polypeptide binding]; other site
1163389001594	RPB11 interaction site [polypeptide binding]; other site
1163389001595	RPB10 interaction site [polypeptide binding]; other site
1163389001596	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1163389001597	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1163389001598	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1163389001599	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1163389001600	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1163389001601	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1163389001602	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1163389001603	cleft; other site
1163389001604	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1163389001605	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
1163389001606	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1163389001607	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
1163389001608	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1163389001609	DNA binding site [nucleotide binding]
1163389001610	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1163389001611	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
1163389001612	UGMP family protein; Validated; Region: PRK09604
1163389001613	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1163389001614	Di-iron ligands [ion binding]; other site
1163389001615	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1163389001616	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1163389001617	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1163389001618	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1163389001619	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1163389001620	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1163389001621	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591
1163389001622	RimM N-terminal domain; Region: RimM; pfam01782
1163389001623	PRC-barrel domain; Region: PRC; pfam05239
1163389001624	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1163389001625	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1163389001626	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1163389001627	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1163389001628	active site
1163389001629	DNA binding site [nucleotide binding]
1163389001630	Int/Topo IB signature motif; other site
1163389001631	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
1163389001632	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
1163389001633	Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476
1163389001634	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
1163389001635	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
1163389001636	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
1163389001637	classical (c) SDRs; Region: SDR_c; cd05233
1163389001638	NAD(P) binding site [chemical binding]; other site
1163389001639	active site
1163389001640	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1163389001641	putative active site [active]
1163389001642	Ap4A binding site [chemical binding]; other site
1163389001643	nudix motif; other site
1163389001644	putative metal binding site [ion binding]; other site
1163389001645	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1163389001646	active site
1163389001647	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1163389001648	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1163389001649	amidase catalytic site [active]
1163389001650	Zn binding residues [ion binding]; other site
1163389001651	substrate binding site [chemical binding]; other site
1163389001652	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1163389001653	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1163389001654	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1163389001655	Mg2+ binding site [ion binding]; other site
1163389001656	G-X-G motif; other site
1163389001657	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1163389001658	anchoring element; other site
1163389001659	dimer interface [polypeptide binding]; other site
1163389001660	ATP binding site [chemical binding]; other site
1163389001661	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1163389001662	active site
1163389001663	metal binding site [ion binding]; metal-binding site
1163389001664	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1163389001665	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389001666	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1163389001667	putative substrate translocation pore; other site
1163389001668	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
1163389001669	Trp docking motif [polypeptide binding]; other site
1163389001670	PQQ-like domain; Region: PQQ_2; pfam13360
1163389001671	PQQ-like domain; Region: PQQ_2; pfam13360
1163389001672	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
1163389001673	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1163389001674	TPR motif; other site
1163389001675	binding surface
1163389001676	glutamyl-tRNA reductase; Provisional; Region: PRK13940
1163389001677	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1163389001678	tRNA; other site
1163389001679	putative tRNA binding site [nucleotide binding]; other site
1163389001680	putative NADP binding site [chemical binding]; other site
1163389001681	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1163389001682	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1163389001683	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1163389001684	RF-1 domain; Region: RF-1; pfam00472
1163389001685	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1163389001686	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1163389001687	S-adenosylmethionine binding site [chemical binding]; other site
1163389001688	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1163389001689	hypothetical protein; Validated; Region: PRK02101
1163389001690	Protein of unknown function (DUF3261); Region: DUF3261; pfam11659
1163389001691	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
1163389001692	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1163389001693	active site
1163389001694	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1163389001695	putative acyl-acceptor binding pocket; other site
1163389001696	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1163389001697	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1163389001698	Ligand binding site; other site
1163389001699	Putative Catalytic site; other site
1163389001700	DXD motif; other site
1163389001701	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1163389001702	active site 2 [active]
1163389001703	active site 1 [active]
1163389001704	Predicted membrane protein [Function unknown]; Region: COG4648
1163389001705	acyl carrier protein; Provisional; Region: PRK05350
1163389001706	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1163389001707	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1163389001708	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1163389001709	putative acyl-acceptor binding pocket; other site
1163389001710	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
1163389001711	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
1163389001712	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1163389001713	dimer interface [polypeptide binding]; other site
1163389001714	active site
1163389001715	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1163389001716	active site 2 [active]
1163389001717	active site 1 [active]
1163389001718	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1163389001719	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
1163389001720	NAD(P) binding site [chemical binding]; other site
1163389001721	active site
1163389001722	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
1163389001723	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1163389001724	dimer interface [polypeptide binding]; other site
1163389001725	active site
1163389001726	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1163389001727	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1163389001728	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1163389001729	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
1163389001730	G1 box; other site
1163389001731	GTP/Mg2+ binding site [chemical binding]; other site
1163389001732	Switch I region; other site
1163389001733	G2 box; other site
1163389001734	G3 box; other site
1163389001735	Switch II region; other site
1163389001736	G4 box; other site
1163389001737	G5 box; other site
1163389001738	Nucleoside recognition; Region: Gate; pfam07670
1163389001739	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1163389001740	Nucleoside recognition; Region: Gate; pfam07670
1163389001741	FeoA domain; Region: FeoA; cl00838
1163389001742	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1163389001743	oligomerisation interface [polypeptide binding]; other site
1163389001744	mobile loop; other site
1163389001745	roof hairpin; other site
1163389001746	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1163389001747	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1163389001748	ring oligomerisation interface [polypeptide binding]; other site
1163389001749	ATP/Mg binding site [chemical binding]; other site
1163389001750	stacking interactions; other site
1163389001751	hinge regions; other site
1163389001752	short chain dehydrogenase; Provisional; Region: PRK05993
1163389001753	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1163389001754	NADP binding site [chemical binding]; other site
1163389001755	active site
1163389001756	steroid binding site; other site
1163389001757	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1163389001758	DNA-binding interface [nucleotide binding]; DNA binding site
1163389001759	HI0933-like protein; Region: HI0933_like; pfam03486
1163389001760	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1163389001761	glutamate dehydrogenase; Provisional; Region: PRK09414
1163389001762	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1163389001763	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1163389001764	NAD(P) binding site [chemical binding]; other site
1163389001765	Amino acid permease; Region: AA_permease_2; pfam13520
1163389001766	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1163389001767	mercuric reductase; Validated; Region: PRK06370
1163389001768	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1163389001769	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1163389001770	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1163389001771	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
1163389001772	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1163389001773	HSP70 interaction site [polypeptide binding]; other site
1163389001774	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1163389001775	substrate binding site [polypeptide binding]; other site
1163389001776	dimer interface [polypeptide binding]; other site
1163389001777	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1163389001778	aromatic amino acid transport protein; Region: araaP; TIGR00837
1163389001779	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1163389001780	HD domain; Region: HD_4; pfam13328
1163389001781	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1163389001782	synthetase active site [active]
1163389001783	NTP binding site [chemical binding]; other site
1163389001784	metal binding site [ion binding]; metal-binding site
1163389001785	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1163389001786	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
1163389001787	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
1163389001788	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1163389001789	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1163389001790	active site
1163389001791	DNA binding site [nucleotide binding]
1163389001792	Int/Topo IB signature motif; other site
1163389001793	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1163389001794	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1163389001795	preprotein translocase subunit SecB; Validated; Region: PRK05751
1163389001796	SecA binding site; other site
1163389001797	Preprotein binding site; other site
1163389001798	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1163389001799	MutS domain I; Region: MutS_I; pfam01624
1163389001800	MutS domain II; Region: MutS_II; pfam05188
1163389001801	MutS domain III; Region: MutS_III; pfam05192
1163389001802	MutS domain V; Region: MutS_V; pfam00488
1163389001803	Walker A/P-loop; other site
1163389001804	ATP binding site [chemical binding]; other site
1163389001805	Q-loop/lid; other site
1163389001806	ABC transporter signature motif; other site
1163389001807	Walker B; other site
1163389001808	D-loop; other site
1163389001809	H-loop/switch region; other site
1163389001810	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1163389001811	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1163389001812	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1163389001813	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1163389001814	putative active site [active]
1163389001815	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1163389001816	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1163389001817	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1163389001818	active site
1163389001819	HIGH motif; other site
1163389001820	dimer interface [polypeptide binding]; other site
1163389001821	KMSKS motif; other site
1163389001822	dephospho-CoA kinase; Region: TIGR00152
1163389001823	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1163389001824	CoA-binding site [chemical binding]; other site
1163389001825	ATP-binding [chemical binding]; other site
1163389001826	Uncharacterized conserved protein [Function unknown]; Region: COG1565
1163389001827	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1163389001828	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1163389001829	dimer interface [polypeptide binding]; other site
1163389001830	TPP-binding site [chemical binding]; other site
1163389001831	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
1163389001832	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1163389001833	E3 interaction surface; other site
1163389001834	lipoyl attachment site [posttranslational modification]; other site
1163389001835	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1163389001836	E3 interaction surface; other site
1163389001837	lipoyl attachment site [posttranslational modification]; other site
1163389001838	e3 binding domain; Region: E3_binding; pfam02817
1163389001839	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1163389001840	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
1163389001841	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1163389001842	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1163389001843	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1163389001844	potential frameshift: common BLAST hit: gi|167627638|ref|YP_001678138.1| alkaline phosphatase
1163389001845	POT family; Region: PTR2; cl17359
1163389001846	POT family; Region: PTR2; cl17359
1163389001847	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1163389001848	ligand binding site [chemical binding]; other site
1163389001849	active site
1163389001850	UGI interface [polypeptide binding]; other site
1163389001851	catalytic site [active]
1163389001852	Protein of unknown function (DUF461); Region: DUF461; cl01071
1163389001853	DNA gyrase subunit A; Validated; Region: PRK05560
1163389001854	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1163389001855	CAP-like domain; other site
1163389001856	active site
1163389001857	primary dimer interface [polypeptide binding]; other site
1163389001858	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1163389001859	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1163389001860	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1163389001861	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1163389001862	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1163389001863	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1163389001864	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1163389001865	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1163389001866	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1163389001867	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1163389001868	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
1163389001869	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1163389001870	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1163389001871	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1163389001872	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1163389001873	Surface antigen; Region: Bac_surface_Ag; pfam01103
1163389001874	periplasmic chaperone; Provisional; Region: PRK10780
1163389001875	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1163389001876	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1163389001877	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1163389001878	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1163389001879	trimer interface [polypeptide binding]; other site
1163389001880	active site
1163389001881	UDP-GlcNAc binding site [chemical binding]; other site
1163389001882	lipid binding site [chemical binding]; lipid-binding site
1163389001883	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1163389001884	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1163389001885	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1163389001886	active site
1163389001887	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1163389001888	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1163389001889	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1163389001890	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1163389001891	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1163389001892	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1163389001893	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1163389001894	substrate binding pocket [chemical binding]; other site
1163389001895	chain length determination region; other site
1163389001896	substrate-Mg2+ binding site; other site
1163389001897	catalytic residues [active]
1163389001898	aspartate-rich region 1; other site
1163389001899	active site lid residues [active]
1163389001900	aspartate-rich region 2; other site
1163389001901	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1163389001902	dimerization interface [polypeptide binding]; other site
1163389001903	active site
1163389001904	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1163389001905	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1163389001906	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1163389001907	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1163389001908	active site
1163389001909	phosphorylation site [posttranslational modification]
1163389001910	intermolecular recognition site; other site
1163389001911	dimerization interface [polypeptide binding]; other site
1163389001912	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1163389001913	DNA binding site [nucleotide binding]
1163389001914	signal peptidase I; Provisional; Region: PRK10861
1163389001915	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1163389001916	Catalytic site [active]
1163389001917	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1163389001918	ribonuclease III; Reviewed; Region: rnc; PRK00102
1163389001919	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1163389001920	dimerization interface [polypeptide binding]; other site
1163389001921	active site
1163389001922	metal binding site [ion binding]; metal-binding site
1163389001923	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1163389001924	dsRNA binding site [nucleotide binding]; other site
1163389001925	ribonuclease R; Region: RNase_R; TIGR02063
1163389001926	RNB domain; Region: RNB; pfam00773
1163389001927	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1163389001928	RNA binding site [nucleotide binding]; other site
1163389001929	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1163389001930	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1163389001931	NAD(P) binding site [chemical binding]; other site
1163389001932	active site
1163389001933	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
1163389001934	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1163389001935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1163389001936	active site
1163389001937	phosphorylation site [posttranslational modification]
1163389001938	intermolecular recognition site; other site
1163389001939	dimerization interface [polypeptide binding]; other site
1163389001940	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1163389001941	DNA binding site [nucleotide binding]
1163389001942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1163389001943	S-adenosylmethionine binding site [chemical binding]; other site
1163389001944	uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722
1163389001945	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
1163389001946	ornithine cyclodeaminase; Validated; Region: PRK07589
1163389001947	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1163389001948	Arginase family; Region: Arginase; cd09989
1163389001949	active site
1163389001950	Mn binding site [ion binding]; other site
1163389001951	oligomer interface [polypeptide binding]; other site
1163389001952	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1163389001953	CoenzymeA binding site [chemical binding]; other site
1163389001954	subunit interaction site [polypeptide binding]; other site
1163389001955	PHB binding site; other site
1163389001956	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
1163389001957	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1163389001958	dimer interface [polypeptide binding]; other site
1163389001959	active site
1163389001960	Acyl CoA binding protein; Region: ACBP; pfam00887
1163389001961	acyl-CoA binding pocket [chemical binding]; other site
1163389001962	CoA binding site [chemical binding]; other site
1163389001963	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1163389001964	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1163389001965	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1163389001966	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1163389001967	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1163389001968	substrate binding site [chemical binding]; other site
1163389001969	oxyanion hole (OAH) forming residues; other site
1163389001970	trimer interface [polypeptide binding]; other site
1163389001971	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
1163389001972	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1163389001973	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1163389001974	active site
1163389001975	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
1163389001976	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
1163389001977	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1163389001978	acyl-activating enzyme (AAE) consensus motif; other site
1163389001979	putative AMP binding site [chemical binding]; other site
1163389001980	putative active site [active]
1163389001981	putative CoA binding site [chemical binding]; other site
1163389001982	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1163389001983	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1163389001984	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
1163389001985	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1163389001986	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1163389001987	NAD(P) binding site [chemical binding]; other site
1163389001988	homodimer interface [polypeptide binding]; other site
1163389001989	substrate binding site [chemical binding]; other site
1163389001990	active site
1163389001991	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1163389001992	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1163389001993	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1163389001994	NAD(P) binding site [chemical binding]; other site
1163389001995	active site
1163389001996	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1163389001997	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1163389001998	Substrate binding site; other site
1163389001999	Cupin domain; Region: Cupin_2; cl17218
1163389002000	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1163389002001	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1163389002002	NADP-binding site; other site
1163389002003	homotetramer interface [polypeptide binding]; other site
1163389002004	substrate binding site [chemical binding]; other site
1163389002005	homodimer interface [polypeptide binding]; other site
1163389002006	active site
1163389002007	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1163389002008	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1163389002009	NADP binding site [chemical binding]; other site
1163389002010	active site
1163389002011	putative substrate binding site [chemical binding]; other site
1163389002012	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1163389002013	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1163389002014	substrate binding site; other site
1163389002015	tetramer interface; other site
1163389002016	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1163389002017	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1163389002018	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1163389002019	NADP binding site [chemical binding]; other site
1163389002020	active site
1163389002021	putative substrate binding site [chemical binding]; other site
1163389002022	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1163389002023	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1163389002024	NAD binding site [chemical binding]; other site
1163389002025	substrate binding site [chemical binding]; other site
1163389002026	homodimer interface [polypeptide binding]; other site
1163389002027	active site
1163389002028	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1163389002029	putative trimer interface [polypeptide binding]; other site
1163389002030	putative CoA binding site [chemical binding]; other site
1163389002031	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1163389002032	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1163389002033	dimer interface [polypeptide binding]; other site
1163389002034	active site
1163389002035	CoA binding pocket [chemical binding]; other site
1163389002036	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1163389002037	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
1163389002038	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1163389002039	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1163389002040	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1163389002041	inhibitor-cofactor binding pocket; inhibition site
1163389002042	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389002043	catalytic residue [active]
1163389002044	WbqC-like protein family; Region: WbqC; pfam08889
1163389002045	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1163389002046	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1163389002047	putative trimer interface [polypeptide binding]; other site
1163389002048	putative CoA binding site [chemical binding]; other site
1163389002049	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1163389002050	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1163389002051	active site
1163389002052	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1163389002053	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1163389002054	inhibitor-cofactor binding pocket; inhibition site
1163389002055	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389002056	catalytic residue [active]
1163389002057	WbqC-like protein family; Region: WbqC; pfam08889
1163389002058	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1163389002059	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1163389002060	putative trimer interface [polypeptide binding]; other site
1163389002061	putative CoA binding site [chemical binding]; other site
1163389002062	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1163389002063	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
1163389002064	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1163389002065	NAD(P) binding site [chemical binding]; other site
1163389002066	active site
1163389002067	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1163389002068	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1163389002069	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1163389002070	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1163389002071	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1163389002072	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1163389002073	acyl-activating enzyme (AAE) consensus motif; other site
1163389002074	AMP binding site [chemical binding]; other site
1163389002075	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1163389002076	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1163389002077	active site
1163389002078	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1163389002079	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1163389002080	active site
1163389002081	WxcM-like, C-terminal; Region: FdtA; pfam05523
1163389002082	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
1163389002083	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
1163389002084	putative trimer interface [polypeptide binding]; other site
1163389002085	putative active site [active]
1163389002086	putative substrate binding site [chemical binding]; other site
1163389002087	putative CoA binding site [chemical binding]; other site
1163389002088	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1163389002089	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1163389002090	inhibitor-cofactor binding pocket; inhibition site
1163389002091	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389002092	catalytic residue [active]
1163389002093	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1163389002094	active site
1163389002095	Rhamnan synthesis protein F; Region: RgpF; pfam05045
1163389002096	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1163389002097	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1163389002098	active site
1163389002099	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1163389002100	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1163389002101	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1163389002102	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1163389002103	Walker A/P-loop; other site
1163389002104	ATP binding site [chemical binding]; other site
1163389002105	Q-loop/lid; other site
1163389002106	ABC transporter signature motif; other site
1163389002107	Walker B; other site
1163389002108	D-loop; other site
1163389002109	H-loop/switch region; other site
1163389002110	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1163389002111	active site
1163389002112	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1163389002113	metal-binding site
1163389002114	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1163389002115	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1163389002116	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1163389002117	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1163389002118	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1163389002119	metal-binding site
1163389002120	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1163389002121	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
1163389002122	active site
1163389002123	substrate binding site [chemical binding]; other site
1163389002124	metal binding site [ion binding]; metal-binding site
1163389002125	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1163389002126	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1163389002127	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1163389002128	RNA binding site [nucleotide binding]; other site
1163389002129	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1163389002130	multimer interface [polypeptide binding]; other site
1163389002131	Walker A motif; other site
1163389002132	ATP binding site [chemical binding]; other site
1163389002133	Walker B motif; other site
1163389002134	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1163389002135	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1163389002136	catalytic residues [active]
1163389002137	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1163389002138	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1163389002139	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1163389002140	Walker A motif; other site
1163389002141	ATP binding site [chemical binding]; other site
1163389002142	Walker B motif; other site
1163389002143	recombination factor protein RarA; Provisional; Region: PRK14700
1163389002144	arginine finger; other site
1163389002145	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1163389002146	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1163389002147	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1163389002148	dimer interface [polypeptide binding]; other site
1163389002149	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1163389002150	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1163389002151	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1163389002152	active site
1163389002153	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1163389002154	Cupin domain; Region: Cupin_2; pfam07883
1163389002155	Protein of unknown function (DUF523); Region: DUF523; cl00733
1163389002156	hypothetical protein; Provisional; Region: PRK10621
1163389002157	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1163389002158	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1163389002159	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
1163389002160	Walker A/P-loop; other site
1163389002161	ATP binding site [chemical binding]; other site
1163389002162	Q-loop/lid; other site
1163389002163	ABC transporter signature motif; other site
1163389002164	Walker B; other site
1163389002165	D-loop; other site
1163389002166	H-loop/switch region; other site
1163389002167	inner membrane transport permease; Provisional; Region: PRK15066
1163389002168	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1163389002169	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1163389002170	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1163389002171	Ligand binding site; other site
1163389002172	Putative Catalytic site; other site
1163389002173	DXD motif; other site
1163389002174	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
1163389002175	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
1163389002176	LysE type translocator; Region: LysE; cl00565
1163389002177	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
1163389002178	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1163389002179	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1163389002180	Coenzyme A binding pocket [chemical binding]; other site
1163389002181	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1163389002182	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1163389002183	dimerization interface [polypeptide binding]; other site
1163389002184	putative DNA binding site [nucleotide binding]; other site
1163389002185	putative Zn2+ binding site [ion binding]; other site
1163389002186	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
1163389002187	hypothetical protein; Provisional; Region: PRK05170
1163389002188	lipoprotein NlpI; Provisional; Region: PRK11189
1163389002189	transcription antitermination factor NusB; Region: nusB; TIGR01951
1163389002190	putative RNA binding site [nucleotide binding]; other site
1163389002191	C-N hydrolase family amidase; Provisional; Region: PRK10438
1163389002192	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
1163389002193	putative active site [active]
1163389002194	catalytic triad [active]
1163389002195	dimer interface [polypeptide binding]; other site
1163389002196	multimer interface [polypeptide binding]; other site
1163389002197	methionine aminotransferase; Validated; Region: PRK09082
1163389002198	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1163389002199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389002200	homodimer interface [polypeptide binding]; other site
1163389002201	catalytic residue [active]
1163389002202	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1163389002203	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1163389002204	dimer interface [polypeptide binding]; other site
1163389002205	motif 1; other site
1163389002206	active site
1163389002207	motif 2; other site
1163389002208	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1163389002209	putative deacylase active site [active]
1163389002210	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1163389002211	active site
1163389002212	motif 3; other site
1163389002213	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1163389002214	anticodon binding site; other site
1163389002215	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
1163389002216	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
1163389002217	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1163389002218	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1163389002219	active site
1163389002220	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1163389002221	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1163389002222	Sporulation related domain; Region: SPOR; pfam05036
1163389002223	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
1163389002224	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1163389002225	non-specific DNA binding site [nucleotide binding]; other site
1163389002226	salt bridge; other site
1163389002227	sequence-specific DNA binding site [nucleotide binding]; other site
1163389002228	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1163389002229	Catalytic site [active]
1163389002230	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1163389002231	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1163389002232	active site
1163389002233	FMN binding site [chemical binding]; other site
1163389002234	substrate binding site [chemical binding]; other site
1163389002235	3Fe-4S cluster binding site [ion binding]; other site
1163389002236	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
1163389002237	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1163389002238	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1163389002239	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1163389002240	active site
1163389002241	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
1163389002242	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
1163389002243	Family description; Region: UvrD_C_2; pfam13538
1163389002244	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1163389002245	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
1163389002246	AAA domain; Region: AAA_30; pfam13604
1163389002247	Family description; Region: UvrD_C_2; pfam13538
1163389002248	Type III pantothenate kinase; Region: Pan_kinase; cl17198
1163389002249	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1163389002250	tetramerization interface [polypeptide binding]; other site
1163389002251	active site
1163389002252	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1163389002253	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1163389002254	active site
1163389002255	nucleotide binding site [chemical binding]; other site
1163389002256	HIGH motif; other site
1163389002257	KMSKS motif; other site
1163389002258	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1163389002259	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1163389002260	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1163389002261	nucleotide binding pocket [chemical binding]; other site
1163389002262	K-X-D-G motif; other site
1163389002263	catalytic site [active]
1163389002264	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1163389002265	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1163389002266	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1163389002267	Dimer interface [polypeptide binding]; other site
1163389002268	BRCT sequence motif; other site
1163389002269	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
1163389002270	16S rRNA methyltransferase B; Provisional; Region: PRK10901
1163389002271	NusB family; Region: NusB; pfam01029
1163389002272	putative RNA binding site [nucleotide binding]; other site
1163389002273	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1163389002274	S-adenosylmethionine binding site [chemical binding]; other site
1163389002275	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1163389002276	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1163389002277	active site
1163389002278	dimerization interface [polypeptide binding]; other site
1163389002279	Predicted membrane protein [Function unknown]; Region: COG2855
1163389002280	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389002281	putative substrate translocation pore; other site
1163389002282	YCII-related domain; Region: YCII; cl00999
1163389002283	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1163389002284	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1163389002285	dimer interface [polypeptide binding]; other site
1163389002286	active site
1163389002287	acyl carrier protein; Provisional; Region: acpP; PRK00982
1163389002288	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1163389002289	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1163389002290	NAD(P) binding site [chemical binding]; other site
1163389002291	homotetramer interface [polypeptide binding]; other site
1163389002292	homodimer interface [polypeptide binding]; other site
1163389002293	active site
1163389002294	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1163389002295	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1163389002296	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1163389002297	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1163389002298	dimer interface [polypeptide binding]; other site
1163389002299	active site
1163389002300	CoA binding pocket [chemical binding]; other site
1163389002301	putative phosphate acyltransferase; Provisional; Region: PRK05331
1163389002302	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1163389002303	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
1163389002304	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1163389002305	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1163389002306	TPP-binding site [chemical binding]; other site
1163389002307	dimer interface [polypeptide binding]; other site
1163389002308	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1163389002309	PYR/PP interface [polypeptide binding]; other site
1163389002310	dimer interface [polypeptide binding]; other site
1163389002311	TPP binding site [chemical binding]; other site
1163389002312	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1163389002313	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1163389002314	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1163389002315	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1163389002316	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1163389002317	pyruvate kinase; Provisional; Region: PRK05826
1163389002318	domain interfaces; other site
1163389002319	active site
1163389002320	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1163389002321	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1163389002322	intersubunit interface [polypeptide binding]; other site
1163389002323	active site
1163389002324	zinc binding site [ion binding]; other site
1163389002325	Na+ binding site [ion binding]; other site
1163389002326	potential frameshift: common BLAST hit: gi|337755015|ref|YP_004647526.1| trehalose permease, MFS family, FucP subfamily
1163389002327	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1163389002328	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1163389002329	type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358
1163389002330	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
1163389002331	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1163389002332	Intracellular growth locus C protein; Region: IglC; pfam11550
1163389002333	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
1163389002334	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
1163389002335	Active site flap [active]
1163389002336	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1163389002337	non-specific DNA binding site [nucleotide binding]; other site
1163389002338	salt bridge; other site
1163389002339	sequence-specific DNA binding site [nucleotide binding]; other site
1163389002340	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1163389002341	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1163389002342	Walker A motif; other site
1163389002343	ATP binding site [chemical binding]; other site
1163389002344	Walker B motif; other site
1163389002345	arginine finger; other site
1163389002346	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1163389002347	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1163389002348	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
1163389002349	active site
1163389002350	catalytic triad [active]
1163389002351	oxyanion hole [active]
1163389002352	switch loop; other site
1163389002353	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1163389002354	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1163389002355	TPP-binding site; other site
1163389002356	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1163389002357	PYR/PP interface [polypeptide binding]; other site
1163389002358	dimer interface [polypeptide binding]; other site
1163389002359	TPP binding site [chemical binding]; other site
1163389002360	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1163389002361	GMP synthase; Reviewed; Region: guaA; PRK00074
1163389002362	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1163389002363	AMP/PPi binding site [chemical binding]; other site
1163389002364	candidate oxyanion hole; other site
1163389002365	catalytic triad [active]
1163389002366	potential glutamine specificity residues [chemical binding]; other site
1163389002367	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1163389002368	ATP Binding subdomain [chemical binding]; other site
1163389002369	Ligand Binding sites [chemical binding]; other site
1163389002370	Dimerization subdomain; other site
1163389002371	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1163389002372	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1163389002373	dimerization interface 3.5A [polypeptide binding]; other site
1163389002374	active site
1163389002375	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1163389002376	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1163389002377	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1163389002378	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1163389002379	Walker A/P-loop; other site
1163389002380	ATP binding site [chemical binding]; other site
1163389002381	Q-loop/lid; other site
1163389002382	ABC transporter signature motif; other site
1163389002383	Walker B; other site
1163389002384	D-loop; other site
1163389002385	H-loop/switch region; other site
1163389002386	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1163389002387	OstA-like protein; Region: OstA; cl00844
1163389002388	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1163389002389	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1163389002390	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1163389002391	active site
1163389002392	motif I; other site
1163389002393	motif II; other site
1163389002394	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1163389002395	dimer interface [polypeptide binding]; other site
1163389002396	substrate binding site [chemical binding]; other site
1163389002397	metal binding sites [ion binding]; metal-binding site
1163389002398	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1163389002399	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1163389002400	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1163389002401	Protein of unknown function (DUF493); Region: DUF493; pfam04359
1163389002402	lipoate-protein ligase B; Provisional; Region: PRK14342
1163389002403	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
1163389002404	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1163389002405	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1163389002406	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1163389002407	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1163389002408	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1163389002409	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1163389002410	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1163389002411	DNA binding residues [nucleotide binding]
1163389002412	DNA primase; Validated; Region: dnaG; PRK05667
1163389002413	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1163389002414	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1163389002415	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1163389002416	active site
1163389002417	metal binding site [ion binding]; metal-binding site
1163389002418	interdomain interaction site; other site
1163389002419	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1163389002420	Yqey-like protein; Region: YqeY; pfam09424
1163389002421	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1163389002422	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1163389002423	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1163389002424	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1163389002425	catalytic residue [active]
1163389002426	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1163389002427	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1163389002428	Ligand Binding Site [chemical binding]; other site
1163389002429	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1163389002430	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1163389002431	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1163389002432	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1163389002433	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1163389002434	substrate binding pocket [chemical binding]; other site
1163389002435	chain length determination region; other site
1163389002436	substrate-Mg2+ binding site; other site
1163389002437	catalytic residues [active]
1163389002438	aspartate-rich region 1; other site
1163389002439	active site lid residues [active]
1163389002440	aspartate-rich region 2; other site
1163389002441	PQ loop repeat; Region: PQ-loop; cl17546
1163389002442	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1163389002443	Coenzyme A binding pocket [chemical binding]; other site
1163389002444	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1163389002445	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1163389002446	RNA binding surface [nucleotide binding]; other site
1163389002447	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1163389002448	active site
1163389002449	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
1163389002450	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1163389002451	FeS/SAM binding site; other site
1163389002452	replicative DNA helicase; Region: DnaB; TIGR00665
1163389002453	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1163389002454	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1163389002455	Walker A motif; other site
1163389002456	ATP binding site [chemical binding]; other site
1163389002457	Walker B motif; other site
1163389002458	DNA binding loops [nucleotide binding]
1163389002459	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1163389002460	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1163389002461	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1163389002462	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1163389002463	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1163389002464	S1 domain; Region: S1_2; pfam13509
1163389002465	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1163389002466	S1 domain; Region: S1_2; pfam13509
1163389002467	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
1163389002468	Part of AAA domain; Region: AAA_19; pfam13245
1163389002469	Family description; Region: UvrD_C_2; pfam13538
1163389002470	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1163389002471	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1163389002472	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1163389002473	transaldolase-like protein; Provisional; Region: PTZ00411
1163389002474	active site
1163389002475	dimer interface [polypeptide binding]; other site
1163389002476	catalytic residue [active]
1163389002477	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1163389002478	interface (dimer of trimers) [polypeptide binding]; other site
1163389002479	Substrate-binding/catalytic site; other site
1163389002480	Zn-binding sites [ion binding]; other site
1163389002481	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1163389002482	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1163389002483	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1163389002484	motif 1; other site
1163389002485	active site
1163389002486	motif 2; other site
1163389002487	motif 3; other site
1163389002488	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1163389002489	DHHA1 domain; Region: DHHA1; pfam02272
1163389002490	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1163389002491	Part of AAA domain; Region: AAA_19; pfam13245
1163389002492	Family description; Region: UvrD_C_2; pfam13538
1163389002493	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1163389002494	potential frameshift: common BLAST hit: gi|167627896|ref|YP_001678396.1| 4Fe-4S ferredoxin
1163389002495	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1163389002496	potential frameshift: common BLAST hit: gi|337755471|ref|YP_004647982.1| (Fe-S)-binding protein
1163389002497	epoxyqueuosine reductase; Region: TIGR00276
1163389002498	epoxyqueuosine reductase; Region: TIGR00276
1163389002499	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1163389002500	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1163389002501	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1163389002502	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1163389002503	catalytic residues [active]
1163389002504	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
1163389002505	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
1163389002506	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
1163389002507	BCCT family transporter; Region: BCCT; cl00569
1163389002508	BCCT family transporter; Region: BCCT; cl00569
1163389002509	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1163389002510	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1163389002511	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1163389002512	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1163389002513	active site
1163389002514	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1163389002515	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1163389002516	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1163389002517	catalytic residues [active]
1163389002518	dimer interface [polypeptide binding]; other site
1163389002519	Chorismate mutase type II; Region: CM_2; smart00830
1163389002520	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
1163389002521	catalytic triad [active]
1163389002522	dimer interface [polypeptide binding]; other site
1163389002523	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1163389002524	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1163389002525	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1163389002526	dimerization interface [polypeptide binding]; other site
1163389002527	potential frameshift: common BLAST hit: gi|326402911|ref|YP_004282992.1| putative multicopper oxidase
1163389002528	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1163389002529	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1163389002530	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1163389002531	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
1163389002532	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1163389002533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
1163389002534	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1163389002535	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1163389002536	active site
1163389002537	catalytic site [active]
1163389002538	substrate binding site [chemical binding]; other site
1163389002539	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1163389002540	PhnA protein; Region: PhnA; pfam03831
1163389002541	peroxidase; Provisional; Region: PRK15000
1163389002542	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1163389002543	dimer interface [polypeptide binding]; other site
1163389002544	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1163389002545	catalytic triad [active]
1163389002546	peroxidatic and resolving cysteines [active]
1163389002547	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1163389002548	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1163389002549	motif II; other site
1163389002550	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1163389002551	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1163389002552	putative ATP binding site [chemical binding]; other site
1163389002553	putative substrate interface [chemical binding]; other site
1163389002554	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1163389002555	catalytic residue [active]
1163389002556	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1163389002557	Peptidase family M50; Region: Peptidase_M50; pfam02163
1163389002558	active site
1163389002559	putative substrate binding region [chemical binding]; other site
1163389002560	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
1163389002561	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
1163389002562	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1163389002563	active site
1163389002564	nucleotide binding site [chemical binding]; other site
1163389002565	HIGH motif; other site
1163389002566	KMSKS motif; other site
1163389002567	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
1163389002568	nudix motif; other site
1163389002569	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
1163389002570	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1163389002571	Substrate binding site; other site
1163389002572	Mg++ binding site; other site
1163389002573	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1163389002574	active site
1163389002575	substrate binding site [chemical binding]; other site
1163389002576	CoA binding site [chemical binding]; other site
1163389002577	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1163389002578	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1163389002579	glutaminase active site [active]
1163389002580	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1163389002581	dimer interface [polypeptide binding]; other site
1163389002582	active site
1163389002583	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1163389002584	dimer interface [polypeptide binding]; other site
1163389002585	active site
1163389002586	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1163389002587	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1163389002588	DNA-binding site [nucleotide binding]; DNA binding site
1163389002589	RNA-binding motif; other site
1163389002590	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1163389002591	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1163389002592	active site
1163389002593	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1163389002594	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1163389002595	CAP-like domain; other site
1163389002596	active site
1163389002597	primary dimer interface [polypeptide binding]; other site
1163389002598	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1163389002599	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1163389002600	lytic murein transglycosylase; Provisional; Region: PRK11619
1163389002601	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1163389002602	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1163389002603	catalytic residue [active]
1163389002604	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1163389002605	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1163389002606	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1163389002607	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1163389002608	putative active site [active]
1163389002609	putative PHP Thumb interface [polypeptide binding]; other site
1163389002610	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1163389002611	generic binding surface II; other site
1163389002612	generic binding surface I; other site
1163389002613	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1163389002614	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1163389002615	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1163389002616	FtsX-like permease family; Region: FtsX; pfam02687
1163389002617	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
1163389002618	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1163389002619	Walker A/P-loop; other site
1163389002620	ATP binding site [chemical binding]; other site
1163389002621	Q-loop/lid; other site
1163389002622	ABC transporter signature motif; other site
1163389002623	Walker B; other site
1163389002624	D-loop; other site
1163389002625	H-loop/switch region; other site
1163389002626	lysine decarboxylase LdcC; Provisional; Region: PRK15399
1163389002627	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1163389002628	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1163389002629	homodimer interface [polypeptide binding]; other site
1163389002630	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389002631	catalytic residue [active]
1163389002632	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1163389002633	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1163389002634	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1163389002635	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1163389002636	lipoyl attachment site [posttranslational modification]; other site
1163389002637	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
1163389002638	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1163389002639	tetramer interface [polypeptide binding]; other site
1163389002640	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389002641	catalytic residue [active]
1163389002642	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1163389002643	tetramer interface [polypeptide binding]; other site
1163389002644	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389002645	catalytic residue [active]
1163389002646	CAAX protease self-immunity; Region: Abi; pfam02517
1163389002647	Homoserine O-succinyltransferase; Region: HTS; pfam04204
1163389002648	pullulanase, type I; Region: pulA_typeI; TIGR02104
1163389002649	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1163389002650	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1163389002651	Ca binding site [ion binding]; other site
1163389002652	active site
1163389002653	catalytic site [active]
1163389002654	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
1163389002655	glycogen branching enzyme; Provisional; Region: PRK12313
1163389002656	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1163389002657	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1163389002658	active site
1163389002659	catalytic site [active]
1163389002660	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1163389002661	phosphoglucomutase; Region: PLN02307
1163389002662	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
1163389002663	substrate binding site [chemical binding]; other site
1163389002664	dimer interface [polypeptide binding]; other site
1163389002665	active site
1163389002666	metal binding site [ion binding]; metal-binding site
1163389002667	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
1163389002668	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1163389002669	ligand binding site; other site
1163389002670	oligomer interface; other site
1163389002671	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1163389002672	dimer interface [polypeptide binding]; other site
1163389002673	N-terminal domain interface [polypeptide binding]; other site
1163389002674	sulfate 1 binding site; other site
1163389002675	glycogen synthase; Provisional; Region: glgA; PRK00654
1163389002676	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1163389002677	ADP-binding pocket [chemical binding]; other site
1163389002678	homodimer interface [polypeptide binding]; other site
1163389002679	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1163389002680	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1163389002681	4-alpha-glucanotransferase; Provisional; Region: PRK14508
1163389002682	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1163389002683	dimer interface [polypeptide binding]; other site
1163389002684	motif 1; other site
1163389002685	active site
1163389002686	motif 2; other site
1163389002687	motif 3; other site
1163389002688	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1163389002689	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1163389002690	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1163389002691	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1163389002692	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1163389002693	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1163389002694	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1163389002695	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1163389002696	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1163389002697	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
1163389002698	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1163389002699	nucleotide binding site [chemical binding]; other site
1163389002700	substrate binding site [chemical binding]; other site
1163389002701	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
1163389002702	dimer interface [polypeptide binding]; other site
1163389002703	putative threonine allosteric regulatory site; other site
1163389002704	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
1163389002705	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1163389002706	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1163389002707	homoserine kinase; Provisional; Region: PRK01212
1163389002708	threonine synthase; Validated; Region: PRK09225
1163389002709	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1163389002710	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1163389002711	catalytic residue [active]
1163389002712	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1163389002713	putative active site [active]
1163389002714	putative metal binding site [ion binding]; other site
1163389002715	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1163389002716	active site
1163389002717	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
1163389002718	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1163389002719	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
1163389002720	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1163389002721	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1163389002722	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1163389002723	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
1163389002724	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1163389002725	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1163389002726	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1163389002727	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1163389002728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389002729	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1163389002730	putative substrate translocation pore; other site
1163389002731	ABC transporter ATPase component; Reviewed; Region: PRK11147
1163389002732	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1163389002733	Walker A/P-loop; other site
1163389002734	ATP binding site [chemical binding]; other site
1163389002735	Q-loop/lid; other site
1163389002736	ABC transporter signature motif; other site
1163389002737	Walker B; other site
1163389002738	D-loop; other site
1163389002739	H-loop/switch region; other site
1163389002740	ABC transporter; Region: ABC_tran_2; pfam12848
1163389002741	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1163389002742	potential frameshift: common BLAST hit: gi|167626516|ref|YP_001677016.1| alkaline phosphatase
1163389002743	POT family; Region: PTR2; cl17359
1163389002744	potential frameshift: common BLAST hit: gi|118497136|ref|YP_898186.1| proton-dependent oligopeptide transporter (POT) family protein, di-
1163389002745	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1163389002746	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1163389002747	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1163389002748	active site
1163389002749	HIGH motif; other site
1163389002750	nucleotide binding site [chemical binding]; other site
1163389002751	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1163389002752	KMSKS motif; other site
1163389002753	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1163389002754	phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344
1163389002755	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1163389002756	active site
1163389002757	metal-binding site [ion binding]
1163389002758	nucleotide-binding site [chemical binding]; other site
1163389002759	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
1163389002760	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1163389002761	Mg++ binding site [ion binding]; other site
1163389002762	putative catalytic motif [active]
1163389002763	putative substrate binding site [chemical binding]; other site
1163389002764	cell division protein FtsW; Region: ftsW; TIGR02614
1163389002765	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1163389002766	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1163389002767	Putative Catalytic site; other site
1163389002768	DXD motif; other site
1163389002769	oxidative damage protection protein; Provisional; Region: PRK05408
1163389002770	DsrC like protein; Region: DsrC; pfam04358
1163389002771	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
1163389002772	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1163389002773	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1163389002774	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
1163389002775	dimer interface [polypeptide binding]; other site
1163389002776	N-terminal domain interface [polypeptide binding]; other site
1163389002777	putative inner membrane peptidase; Provisional; Region: PRK11778
1163389002778	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
1163389002779	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1163389002780	tandem repeat interface [polypeptide binding]; other site
1163389002781	oligomer interface [polypeptide binding]; other site
1163389002782	active site residues [active]
1163389002783	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
1163389002784	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1163389002785	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
1163389002786	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
1163389002787	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1163389002788	dimer interface [polypeptide binding]; other site
1163389002789	active site
1163389002790	Schiff base residues; other site
1163389002791	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1163389002792	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
1163389002793	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
1163389002794	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1163389002795	active site
1163389002796	HIGH motif; other site
1163389002797	nucleotide binding site [chemical binding]; other site
1163389002798	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1163389002799	KMSK motif region; other site
1163389002800	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1163389002801	tRNA binding surface [nucleotide binding]; other site
1163389002802	anticodon binding site; other site
1163389002803	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1163389002804	OstA-like protein; Region: OstA; cl00844
1163389002805	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1163389002806	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
1163389002807	SurA N-terminal domain; Region: SurA_N; pfam09312
1163389002808	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1163389002809	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1163389002810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1163389002811	S-adenosylmethionine binding site [chemical binding]; other site
1163389002812	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
1163389002813	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
1163389002814	active site
1163389002815	metal binding site [ion binding]; metal-binding site
1163389002816	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1163389002817	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1163389002818	trimer interface [polypeptide binding]; other site
1163389002819	active site
1163389002820	dimer interface [polypeptide binding]; other site
1163389002821	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1163389002822	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1163389002823	carboxyltransferase (CT) interaction site; other site
1163389002824	biotinylation site [posttranslational modification]; other site
1163389002825	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1163389002826	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1163389002827	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1163389002828	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1163389002829	Helix-turn-helix domain; Region: HTH_25; pfam13413
1163389002830	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1163389002831	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1163389002832	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1163389002833	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
1163389002834	motif 1; other site
1163389002835	dimer interface [polypeptide binding]; other site
1163389002836	active site
1163389002837	motif 2; other site
1163389002838	motif 3; other site
1163389002839	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1163389002840	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1163389002841	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1163389002842	DHH family; Region: DHH; pfam01368
1163389002843	DHHA1 domain; Region: DHHA1; pfam02272
1163389002844	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1163389002845	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
1163389002846	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1163389002847	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1163389002848	GTPase RsgA; Reviewed; Region: PRK00098
1163389002849	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1163389002850	RNA binding site [nucleotide binding]; other site
1163389002851	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1163389002852	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1163389002853	GTP/Mg2+ binding site [chemical binding]; other site
1163389002854	G4 box; other site
1163389002855	G5 box; other site
1163389002856	G1 box; other site
1163389002857	Switch I region; other site
1163389002858	G2 box; other site
1163389002859	G3 box; other site
1163389002860	Switch II region; other site
1163389002861	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
1163389002862	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
1163389002863	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1163389002864	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1163389002865	ATP binding site [chemical binding]; other site
1163389002866	Mg2+ binding site [ion binding]; other site
1163389002867	G-X-G motif; other site
1163389002868	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
1163389002869	ATP binding site [chemical binding]; other site
1163389002870	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1163389002871	thioredoxin reductase; Provisional; Region: PRK10262
1163389002872	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1163389002873	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1163389002874	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1163389002875	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1163389002876	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1163389002877	motif II; other site
1163389002878	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1163389002879	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1163389002880	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1163389002881	phosphate binding site [ion binding]; other site
1163389002882	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
1163389002883	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
1163389002884	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
1163389002885	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1163389002886	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1163389002887	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1163389002888	CoA binding domain; Region: CoA_binding; smart00881
1163389002889	CoA-ligase; Region: Ligase_CoA; pfam00549
1163389002890	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1163389002891	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1163389002892	CoA-ligase; Region: Ligase_CoA; pfam00549
1163389002893	TIGR03546 family protein; Region: TIGR03546
1163389002894	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1163389002895	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1163389002896	FMN binding site [chemical binding]; other site
1163389002897	active site
1163389002898	catalytic residues [active]
1163389002899	substrate binding site [chemical binding]; other site
1163389002900	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1163389002901	putative active site pocket [active]
1163389002902	dimerization interface [polypeptide binding]; other site
1163389002903	putative catalytic residue [active]
1163389002904	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1163389002905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1163389002906	ATP binding site [chemical binding]; other site
1163389002907	Mg2+ binding site [ion binding]; other site
1163389002908	G-X-G motif; other site
1163389002909	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1163389002910	anchoring element; other site
1163389002911	dimer interface [polypeptide binding]; other site
1163389002912	ATP binding site [chemical binding]; other site
1163389002913	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1163389002914	active site
1163389002915	putative metal-binding site [ion binding]; other site
1163389002916	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1163389002917	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1163389002918	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1163389002919	active site
1163389002920	multimer interface [polypeptide binding]; other site
1163389002921	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1163389002922	predicted active site [active]
1163389002923	catalytic triad [active]
1163389002924	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1163389002925	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1163389002926	DNA binding site [nucleotide binding]
1163389002927	catalytic residue [active]
1163389002928	H2TH interface [polypeptide binding]; other site
1163389002929	putative catalytic residues [active]
1163389002930	turnover-facilitating residue; other site
1163389002931	intercalation triad [nucleotide binding]; other site
1163389002932	8OG recognition residue [nucleotide binding]; other site
1163389002933	putative reading head residues; other site
1163389002934	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1163389002935	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1163389002936	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
1163389002937	AMP-binding enzyme; Region: AMP-binding; pfam00501
1163389002938	acyl-activating enzyme (AAE) consensus motif; other site
1163389002939	putative AMP binding site [chemical binding]; other site
1163389002940	MraW methylase family; Region: Methyltransf_5; cl17771
1163389002941	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1163389002942	Cell division protein FtsL; Region: FtsL; cl11433
1163389002943	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1163389002944	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1163389002945	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1163389002946	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1163389002947	16S/18S rRNA binding site [nucleotide binding]; other site
1163389002948	S13e-L30e interaction site [polypeptide binding]; other site
1163389002949	25S rRNA binding site [nucleotide binding]; other site
1163389002950	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1163389002951	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1163389002952	RNase E interface [polypeptide binding]; other site
1163389002953	trimer interface [polypeptide binding]; other site
1163389002954	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1163389002955	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1163389002956	RNase E interface [polypeptide binding]; other site
1163389002957	trimer interface [polypeptide binding]; other site
1163389002958	active site
1163389002959	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1163389002960	putative nucleic acid binding region [nucleotide binding]; other site
1163389002961	G-X-X-G motif; other site
1163389002962	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1163389002963	RNA binding site [nucleotide binding]; other site
1163389002964	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
1163389002965	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1163389002966	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1163389002967	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1163389002968	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1163389002969	ATP-binding site [chemical binding]; other site
1163389002970	Sugar specificity; other site
1163389002971	Pyrimidine base specificity; other site
1163389002972	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1163389002973	TRAM domain; Region: TRAM; cl01282
1163389002974	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
1163389002975	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1163389002976	S-adenosylmethionine binding site [chemical binding]; other site
1163389002977	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1163389002978	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389002979	putative substrate translocation pore; other site
1163389002980	enolase; Provisional; Region: eno; PRK00077
1163389002981	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1163389002982	dimer interface [polypeptide binding]; other site
1163389002983	metal binding site [ion binding]; metal-binding site
1163389002984	substrate binding pocket [chemical binding]; other site
1163389002985	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1163389002986	Septum formation initiator; Region: DivIC; cl17659
1163389002987	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1163389002988	substrate binding site; other site
1163389002989	dimer interface; other site
1163389002990	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1163389002991	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
1163389002992	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1163389002993	NAD(P) binding site [chemical binding]; other site
1163389002994	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1163389002995	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1163389002996	substrate-cofactor binding pocket; other site
1163389002997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389002998	catalytic residue [active]
1163389002999	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1163389003000	putative efflux protein, MATE family; Region: matE; TIGR00797
1163389003001	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268
1163389003002	putative substrate binding pocket [chemical binding]; other site
1163389003003	trimer interface [polypeptide binding]; other site
1163389003004	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389003005	metabolite-proton symporter; Region: 2A0106; TIGR00883
1163389003006	putative substrate translocation pore; other site
1163389003007	dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232
1163389003008	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1163389003009	Zn2+ binding site [ion binding]; other site
1163389003010	Mg2+ binding site [ion binding]; other site
1163389003011	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1163389003012	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1163389003013	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
1163389003014	heme binding site [chemical binding]; other site
1163389003015	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1163389003016	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
1163389003017	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389003018	putative substrate translocation pore; other site
1163389003019	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1163389003020	Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567
1163389003021	active site
1163389003022	catalytic site [active]
1163389003023	metal binding site [ion binding]; metal-binding site
1163389003024	potential frameshift: common BLAST hit: gi|337755707|ref|YP_004648218.1| membrane fusion protein (MFP) component of efflux pump, membrane
1163389003025	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1163389003026	HlyD family secretion protein; Region: HlyD_3; pfam13437
1163389003027	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1163389003028	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1163389003029	Walker A/P-loop; other site
1163389003030	ATP binding site [chemical binding]; other site
1163389003031	Q-loop/lid; other site
1163389003032	ABC transporter signature motif; other site
1163389003033	Walker B; other site
1163389003034	D-loop; other site
1163389003035	H-loop/switch region; other site
1163389003036	potential frameshift: common BLAST hit: gi|379725696|ref|YP_005317882.1| putative abc-type multidrug transport system permease component abc
1163389003037	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1163389003038	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1163389003039	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1163389003040	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1163389003041	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1163389003042	homotrimer interaction site [polypeptide binding]; other site
1163389003043	putative active site [active]
1163389003044	MAPEG family; Region: MAPEG; pfam01124
1163389003045	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1163389003046	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1163389003047	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1163389003048	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
1163389003049	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1163389003050	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1163389003051	Walker A/P-loop; other site
1163389003052	ATP binding site [chemical binding]; other site
1163389003053	Q-loop/lid; other site
1163389003054	ABC transporter signature motif; other site
1163389003055	Walker B; other site
1163389003056	D-loop; other site
1163389003057	H-loop/switch region; other site
1163389003058	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
1163389003059	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1163389003060	Walker A/P-loop; other site
1163389003061	ATP binding site [chemical binding]; other site
1163389003062	Q-loop/lid; other site
1163389003063	ABC transporter signature motif; other site
1163389003064	Walker B; other site
1163389003065	D-loop; other site
1163389003066	H-loop/switch region; other site
1163389003067	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1163389003068	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1163389003069	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1163389003070	ROK family; Region: ROK; pfam00480
1163389003071	seryl-tRNA synthetase; Provisional; Region: PRK05431
1163389003072	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1163389003073	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1163389003074	dimer interface [polypeptide binding]; other site
1163389003075	active site
1163389003076	motif 1; other site
1163389003077	motif 2; other site
1163389003078	motif 3; other site
1163389003079	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1163389003080	phosphoglyceromutase; Provisional; Region: PRK05434
1163389003081	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1163389003082	FAD binding domain; Region: FAD_binding_4; pfam01565
1163389003083	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1163389003084	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1163389003085	active site
1163389003086	catalytic motif [active]
1163389003087	Zn binding site [ion binding]; other site
1163389003088	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1163389003089	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1163389003090	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
1163389003091	active site
1163389003092	dinuclear metal binding site [ion binding]; other site
1163389003093	dimerization interface [polypeptide binding]; other site
1163389003094	Predicted membrane protein [Function unknown]; Region: COG2860
1163389003095	UPF0126 domain; Region: UPF0126; pfam03458
1163389003096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1163389003097	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1163389003098	S-adenosylmethionine binding site [chemical binding]; other site
1163389003099	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1163389003100	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1163389003101	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1163389003102	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1163389003103	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1163389003104	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1163389003105	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1163389003106	Predicted permeases [General function prediction only]; Region: COG0795
1163389003107	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1163389003108	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1163389003109	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1163389003110	interface (dimer of trimers) [polypeptide binding]; other site
1163389003111	Substrate-binding/catalytic site; other site
1163389003112	Zn-binding sites [ion binding]; other site
1163389003113	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1163389003114	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1163389003115	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1163389003116	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1163389003117	active site
1163389003118	Thiamine pyrophosphokinase; Region: TPK; cd07995
1163389003119	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
1163389003120	active site
1163389003121	dimerization interface [polypeptide binding]; other site
1163389003122	thiamine binding site [chemical binding]; other site
1163389003123	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1163389003124	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1163389003125	active site
1163389003126	dimer interface [polypeptide binding]; other site
1163389003127	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1163389003128	dimer interface [polypeptide binding]; other site
1163389003129	active site
1163389003130	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1163389003131	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1163389003132	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1163389003133	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1163389003134	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1163389003135	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1163389003136	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1163389003137	FtsH Extracellular; Region: FtsH_ext; pfam06480
1163389003138	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1163389003139	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1163389003140	Walker A motif; other site
1163389003141	ATP binding site [chemical binding]; other site
1163389003142	Walker B motif; other site
1163389003143	arginine finger; other site
1163389003144	Peptidase family M41; Region: Peptidase_M41; pfam01434
1163389003145	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1163389003146	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1163389003147	LPP20 lipoprotein; Region: LPP20; pfam02169
1163389003148	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1163389003149	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1163389003150	ATP binding site [chemical binding]; other site
1163389003151	putative Mg++ binding site [ion binding]; other site
1163389003152	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1163389003153	SEC-C motif; Region: SEC-C; pfam02810
1163389003154	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1163389003155	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1163389003156	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1163389003157	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1163389003158	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1163389003159	dimer interface [polypeptide binding]; other site
1163389003160	conserved gate region; other site
1163389003161	putative PBP binding loops; other site
1163389003162	ABC-ATPase subunit interface; other site
1163389003163	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1163389003164	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1163389003165	dimer interface [polypeptide binding]; other site
1163389003166	conserved gate region; other site
1163389003167	putative PBP binding loops; other site
1163389003168	ABC-ATPase subunit interface; other site
1163389003169	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1163389003170	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1163389003171	Walker A/P-loop; other site
1163389003172	ATP binding site [chemical binding]; other site
1163389003173	Q-loop/lid; other site
1163389003174	ABC transporter signature motif; other site
1163389003175	Walker B; other site
1163389003176	D-loop; other site
1163389003177	H-loop/switch region; other site
1163389003178	TOBE domain; Region: TOBE_2; pfam08402
1163389003179	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1163389003180	hypothetical protein; Provisional; Region: PRK14013
1163389003181	GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080
1163389003182	putative C-terminal domain interface [polypeptide binding]; other site
1163389003183	putative GSH binding site [chemical binding]; other site
1163389003184	putative dimer interface [polypeptide binding]; other site
1163389003185	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1163389003186	dimer interface [polypeptide binding]; other site
1163389003187	substrate binding pocket (H-site) [chemical binding]; other site
1163389003188	C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193
1163389003189	putative N-terminal domain interface [polypeptide binding]; other site
1163389003190	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
1163389003191	POT family; Region: PTR2; cl17359
1163389003192	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1163389003193	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1163389003194	active site
1163389003195	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1163389003196	dimer interface [polypeptide binding]; other site
1163389003197	substrate binding site [chemical binding]; other site
1163389003198	catalytic residues [active]
1163389003199	amino acid transporter; Region: 2A0306; TIGR00909
1163389003200	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1163389003201	Prephenate dehydratase; Region: PDT; pfam00800
1163389003202	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1163389003203	putative L-Phe binding site [chemical binding]; other site
1163389003204	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
1163389003205	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1163389003206	active site
1163389003207	metal binding site [ion binding]; metal-binding site
1163389003208	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1163389003209	Protein of unknown function DUF45; Region: DUF45; pfam01863
1163389003210	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1163389003211	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1163389003212	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1163389003213	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1163389003214	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1163389003215	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1163389003216	catalytic residue [active]
1163389003217	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1163389003218	probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406
1163389003219	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1163389003220	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1163389003221	active site
1163389003222	(T/H)XGH motif; other site
1163389003223	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1163389003224	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1163389003225	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1163389003226	ligand binding site [chemical binding]; other site
1163389003227	potential frameshift: common BLAST hit: gi|337755631|ref|YP_004648142.1| type IV fimbrial assembly protein PilC
1163389003228	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1163389003229	potential frameshift: common BLAST hit: gi|167626340|ref|YP_001676840.1| type IV pili polytopic inner membrane protein
1163389003230	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1163389003231	type II secretion system protein F; Region: GspF; TIGR02120
1163389003232	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
1163389003233	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1163389003234	putative active site [active]
1163389003235	catalytic site [active]
1163389003236	putative metal binding site [ion binding]; other site
1163389003237	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
1163389003238	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1163389003239	putative MPT binding site; other site
1163389003240	cyanophycin synthetase; Provisional; Region: PRK14016
1163389003241	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1163389003242	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1163389003243	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1163389003244	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1163389003245	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1163389003246	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1163389003247	homotrimer interaction site [polypeptide binding]; other site
1163389003248	zinc binding site [ion binding]; other site
1163389003249	CDP-binding sites; other site
1163389003250	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1163389003251	active site residue [active]
1163389003252	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1163389003253	active site residue [active]
1163389003254	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1163389003255	aromatic amino acid transport protein; Region: araaP; TIGR00837
1163389003256	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1163389003257	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1163389003258	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1163389003259	Isochorismatase family; Region: Isochorismatase; pfam00857
1163389003260	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1163389003261	catalytic triad [active]
1163389003262	conserved cis-peptide bond; other site
1163389003263	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1163389003264	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1163389003265	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
1163389003266	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1163389003267	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1163389003268	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1163389003269	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1163389003270	Protein export membrane protein; Region: SecD_SecF; pfam02355
1163389003271	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1163389003272	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1163389003273	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1163389003274	DNA binding residues [nucleotide binding]
1163389003275	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1163389003276	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1163389003277	hinge; other site
1163389003278	active site
1163389003279	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1163389003280	RNA/DNA hybrid binding site [nucleotide binding]; other site
1163389003281	active site
1163389003282	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
1163389003283	active site
1163389003284	homodimer interface [polypeptide binding]; other site
1163389003285	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1163389003286	active site clefts [active]
1163389003287	zinc binding site [ion binding]; other site
1163389003288	dimer interface [polypeptide binding]; other site
1163389003289	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1163389003290	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1163389003291	oligomer interface [polypeptide binding]; other site
1163389003292	active site residues [active]
1163389003293	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1163389003294	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1163389003295	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1163389003296	Walker A motif; other site
1163389003297	ATP binding site [chemical binding]; other site
1163389003298	Walker B motif; other site
1163389003299	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1163389003300	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1163389003301	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1163389003302	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1163389003303	Walker A motif; other site
1163389003304	ATP binding site [chemical binding]; other site
1163389003305	Walker B motif; other site
1163389003306	arginine finger; other site
1163389003307	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1163389003308	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1163389003309	IHF dimer interface [polypeptide binding]; other site
1163389003310	IHF - DNA interface [nucleotide binding]; other site
1163389003311	SurA N-terminal domain; Region: SurA_N_3; cl07813
1163389003312	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1163389003313	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1163389003314	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1163389003315	bacterial Hfq-like; Region: Hfq; cd01716
1163389003316	hexamer interface [polypeptide binding]; other site
1163389003317	Sm1 motif; other site
1163389003318	RNA binding site [nucleotide binding]; other site
1163389003319	Sm2 motif; other site
1163389003320	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1163389003321	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1163389003322	HflX GTPase family; Region: HflX; cd01878
1163389003323	G1 box; other site
1163389003324	GTP/Mg2+ binding site [chemical binding]; other site
1163389003325	Switch I region; other site
1163389003326	G2 box; other site
1163389003327	G3 box; other site
1163389003328	Switch II region; other site
1163389003329	G4 box; other site
1163389003330	G5 box; other site
1163389003331	hypothetical protein; Provisional; Region: PRK07588
1163389003332	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1163389003333	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
1163389003334	HflK protein; Region: hflK; TIGR01933
1163389003335	FtsH protease regulator HflC; Provisional; Region: PRK11029
1163389003336	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1163389003337	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1163389003338	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1163389003339	active site
1163389003340	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1163389003341	G1 box; other site
1163389003342	GTP/Mg2+ binding site [chemical binding]; other site
1163389003343	Switch I region; other site
1163389003344	G2 box; other site
1163389003345	G3 box; other site
1163389003346	Switch II region; other site
1163389003347	G4 box; other site
1163389003348	G5 box; other site
1163389003349	potential frameshift: common BLAST hit: gi|337755588|ref|YP_004648099.1| threonine synthase
1163389003350	threonine synthase; Validated; Region: PRK07409
1163389003351	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1163389003352	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1163389003353	potential frameshift: common BLAST hit: gi|167627774|ref|YP_001678274.1| dihydroxy-acid dehydratase
1163389003354	Dehydratase family; Region: ILVD_EDD; cl00340
1163389003355	Dehydratase family; Region: ILVD_EDD; cl00340
1163389003356	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1163389003357	putative valine binding site [chemical binding]; other site
1163389003358	dimer interface [polypeptide binding]; other site
1163389003359	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1163389003360	YccA-like proteins; Region: YccA_like; cd10433
1163389003361	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
1163389003362	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1163389003363	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1163389003364	minor groove reading motif; other site
1163389003365	helix-hairpin-helix signature motif; other site
1163389003366	substrate binding pocket [chemical binding]; other site
1163389003367	active site
1163389003368	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1163389003369	ferredoxin; Provisional; Region: PRK08764
1163389003370	Putative Fe-S cluster; Region: FeS; cl17515
1163389003371	4Fe-4S binding domain; Region: Fer4; pfam00037
1163389003372	glutaredoxin 2; Provisional; Region: PRK10387
1163389003373	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1163389003374	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
1163389003375	N-terminal domain interface [polypeptide binding]; other site
1163389003376	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1163389003377	Ferritin-like domain; Region: Ferritin; pfam00210
1163389003378	ferroxidase diiron center [ion binding]; other site
1163389003379	lipoyl synthase; Provisional; Region: PRK05481
1163389003380	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1163389003381	FeS/SAM binding site; other site
1163389003382	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
1163389003383	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
1163389003384	conserved cys residue [active]
1163389003385	hypothetical protein; Validated; Region: PRK00110
1163389003386	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1163389003387	active site
1163389003388	putative DNA-binding cleft [nucleotide binding]; other site
1163389003389	dimer interface [polypeptide binding]; other site
1163389003390	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389003391	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1163389003392	putative substrate translocation pore; other site
1163389003393	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1163389003394	RuvA N terminal domain; Region: RuvA_N; pfam01330
1163389003395	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1163389003396	RmuC family; Region: RmuC; pfam02646
1163389003397	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337
1163389003398	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1163389003399	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1163389003400	potential frameshift: common BLAST hit: gi|167627802|ref|YP_001678302.1| major facilitator transporter
1163389003401	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1163389003402	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389003403	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1163389003404	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1163389003405	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1163389003406	active site
1163389003407	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1163389003408	5S rRNA interface [nucleotide binding]; other site
1163389003409	CTC domain interface [polypeptide binding]; other site
1163389003410	L16 interface [polypeptide binding]; other site
1163389003411	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
1163389003412	Domain of unknown function DUF21; Region: DUF21; pfam01595
1163389003413	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1163389003414	Transporter associated domain; Region: CorC_HlyC; pfam03471
1163389003415	GTP-binding protein YchF; Reviewed; Region: PRK09601
1163389003416	YchF GTPase; Region: YchF; cd01900
1163389003417	G1 box; other site
1163389003418	GTP/Mg2+ binding site [chemical binding]; other site
1163389003419	Switch I region; other site
1163389003420	G2 box; other site
1163389003421	Switch II region; other site
1163389003422	G3 box; other site
1163389003423	G4 box; other site
1163389003424	G5 box; other site
1163389003425	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1163389003426	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1163389003427	putative active site [active]
1163389003428	catalytic residue [active]
1163389003429	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1163389003430	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1163389003431	dimerization domain [polypeptide binding]; other site
1163389003432	dimer interface [polypeptide binding]; other site
1163389003433	catalytic residues [active]
1163389003434	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1163389003435	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1163389003436	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1163389003437	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
1163389003438	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1163389003439	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1163389003440	Ion transport protein; Region: Ion_trans; pfam00520
1163389003441	Ion channel; Region: Ion_trans_2; pfam07885
1163389003442	TrkA-N domain; Region: TrkA_N; pfam02254
1163389003443	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1163389003444	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1163389003445	Walker A motif; other site
1163389003446	ATP binding site [chemical binding]; other site
1163389003447	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1163389003448	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1163389003449	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1163389003450	active site
1163389003451	HslU subunit interaction site [polypeptide binding]; other site
1163389003452	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1163389003453	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1163389003454	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1163389003455	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1163389003456	active site
1163389003457	HIGH motif; other site
1163389003458	dimer interface [polypeptide binding]; other site
1163389003459	KMSKS motif; other site
1163389003460	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1163389003461	RNA binding surface [nucleotide binding]; other site
1163389003462	potential frameshift: common BLAST hit: gi|170747276|ref|YP_001753536.1| alpha/beta hydrolase domain-containing protein
1163389003463	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1163389003464	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1163389003465	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1163389003466	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1163389003467	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1163389003468	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1163389003469	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1163389003470	putative active site [active]
1163389003471	putative catalytic site [active]
1163389003472	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1163389003473	RNA binding surface [nucleotide binding]; other site
1163389003474	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
1163389003475	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1163389003476	multidrug resistance protein MdtN; Provisional; Region: PRK10476
1163389003477	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1163389003478	HlyD family secretion protein; Region: HlyD_3; pfam13437
1163389003479	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1163389003480	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1163389003481	Bacterial transcriptional regulator; Region: IclR; pfam01614
1163389003482	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1163389003483	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1163389003484	FeS/SAM binding site; other site
1163389003485	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1163389003486	NAD binding site [chemical binding]; other site
1163389003487	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1163389003488	DNA-binding site [nucleotide binding]; DNA binding site
1163389003489	RNA-binding motif; other site
1163389003490	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1163389003491	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1163389003492	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1163389003493	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1163389003494	active site
1163389003495	tetramer interface; other site
1163389003496	acetyl-CoA synthetase; Provisional; Region: PRK00174
1163389003497	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1163389003498	active site
1163389003499	CoA binding site [chemical binding]; other site
1163389003500	acyl-activating enzyme (AAE) consensus motif; other site
1163389003501	AMP binding site [chemical binding]; other site
1163389003502	acetate binding site [chemical binding]; other site
1163389003503	EamA-like transporter family; Region: EamA; pfam00892
1163389003504	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1163389003505	EamA-like transporter family; Region: EamA; pfam00892
1163389003506	recombination protein F; Reviewed; Region: recF; PRK00064
1163389003507	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1163389003508	Walker A/P-loop; other site
1163389003509	ATP binding site [chemical binding]; other site
1163389003510	Q-loop/lid; other site
1163389003511	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1163389003512	ABC transporter signature motif; other site
1163389003513	Walker B; other site
1163389003514	D-loop; other site
1163389003515	H-loop/switch region; other site
1163389003516	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1163389003517	active site
1163389003518	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1163389003519	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1163389003520	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467
1163389003521	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1163389003522	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389003523	putative substrate translocation pore; other site
1163389003524	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1163389003525	catalytic site [active]
1163389003526	putative active site [active]
1163389003527	putative substrate binding site [chemical binding]; other site
1163389003528	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1163389003529	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1163389003530	GIY-YIG motif/motif A; other site
1163389003531	active site
1163389003532	catalytic site [active]
1163389003533	putative DNA binding site [nucleotide binding]; other site
1163389003534	metal binding site [ion binding]; metal-binding site
1163389003535	UvrB/uvrC motif; Region: UVR; pfam02151
1163389003536	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1163389003537	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1163389003538	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1163389003539	active site
1163389003540	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1163389003541	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1163389003542	Ligand Binding Site [chemical binding]; other site
1163389003543	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1163389003544	CPxP  motif; other site
1163389003545	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1163389003546	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1163389003547	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1163389003548	Ligand binding site; other site
1163389003549	oligomer interface; other site
1163389003550	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1163389003551	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1163389003552	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389003553	putative substrate translocation pore; other site
1163389003554	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389003555	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1163389003556	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1163389003557	helicase 45; Provisional; Region: PTZ00424
1163389003558	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1163389003559	ATP binding site [chemical binding]; other site
1163389003560	Mg++ binding site [ion binding]; other site
1163389003561	motif III; other site
1163389003562	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1163389003563	nucleotide binding region [chemical binding]; other site
1163389003564	ATP-binding site [chemical binding]; other site
1163389003565	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1163389003566	putative RNA binding site [nucleotide binding]; other site
1163389003567	Guanylate kinase; Region: Guanylate_kin; pfam00625
1163389003568	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1163389003569	catalytic site [active]
1163389003570	G-X2-G-X-G-K; other site
1163389003571	quinolinate synthetase; Provisional; Region: PRK09375
1163389003572	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
1163389003573	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1163389003574	dimerization interface [polypeptide binding]; other site
1163389003575	active site
1163389003576	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
1163389003577	L-aspartate oxidase; Provisional; Region: PRK06175
1163389003578	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1163389003579	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
1163389003580	cytidylate kinase; Provisional; Region: cmk; PRK00023
1163389003581	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1163389003582	CMP-binding site; other site
1163389003583	The sites determining sugar specificity; other site
1163389003584	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
1163389003585	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1163389003586	catalytic residue [active]
1163389003587	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1163389003588	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
1163389003589	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
1163389003590	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1163389003591	active site residue [active]
1163389003592	Cyclic phosphodiesterase-like protein; Region: CPDase; pfam07823
1163389003593	Putative exonuclease, RdgC; Region: RdgC; cl01122
1163389003594	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522; cl01406
1163389003595	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522; cl01406
1163389003596	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522; cl01406
1163389003597	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
1163389003598	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
1163389003599	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1163389003600	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1163389003601	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1163389003602	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
1163389003603	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
1163389003604	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1163389003605	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1163389003606	Palmitoyl protein thioesterase; Region: Palm_thioest; cl15849
1163389003607	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1163389003608	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1163389003609	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1163389003610	acyl-activating enzyme (AAE) consensus motif; other site
1163389003611	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1163389003612	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1163389003613	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1163389003614	acyl-activating enzyme (AAE) consensus motif; other site
1163389003615	AMP binding site [chemical binding]; other site
1163389003616	Condensation domain; Region: Condensation; pfam00668
1163389003617	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1163389003618	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1163389003619	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1163389003620	acyl-activating enzyme (AAE) consensus motif; other site
1163389003621	AMP binding site [chemical binding]; other site
1163389003622	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1163389003623	dimer interface [polypeptide binding]; other site
1163389003624	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1163389003625	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1163389003626	Condensation domain; Region: Condensation; pfam00668
1163389003627	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1163389003628	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1163389003629	acyl-activating enzyme (AAE) consensus motif; other site
1163389003630	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
1163389003631	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1163389003632	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1163389003633	AMP binding site [chemical binding]; other site
1163389003634	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1163389003635	Condensation domain; Region: Condensation; pfam00668
1163389003636	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1163389003637	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1163389003638	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1163389003639	acyl-activating enzyme (AAE) consensus motif; other site
1163389003640	AMP binding site [chemical binding]; other site
1163389003641	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1163389003642	Condensation domain; Region: Condensation; pfam00668
1163389003643	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1163389003644	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1163389003645	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1163389003646	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1163389003647	acyl-activating enzyme (AAE) consensus motif; other site
1163389003648	AMP binding site [chemical binding]; other site
1163389003649	active site
1163389003650	CoA binding site [chemical binding]; other site
1163389003651	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1163389003652	Condensation domain; Region: Condensation; pfam00668
1163389003653	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1163389003654	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1163389003655	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1163389003656	acyl-activating enzyme (AAE) consensus motif; other site
1163389003657	AMP binding site [chemical binding]; other site
1163389003658	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1163389003659	Condensation domain; Region: Condensation; pfam00668
1163389003660	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1163389003661	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1163389003662	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1163389003663	acyl-activating enzyme (AAE) consensus motif; other site
1163389003664	AMP binding site [chemical binding]; other site
1163389003665	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1163389003666	FMN binding site [chemical binding]; other site
1163389003667	dimer interface [polypeptide binding]; other site
1163389003668	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1163389003669	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1163389003670	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1163389003671	hypothetical protein; Provisional; Region: PRK07206
1163389003672	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1163389003673	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389003674	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
1163389003675	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1163389003676	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1163389003677	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1163389003678	S-adenosylmethionine binding site [chemical binding]; other site
1163389003679	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1163389003680	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1163389003681	ArsC family; Region: ArsC; pfam03960
1163389003682	catalytic residues [active]
1163389003683	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1163389003684	dimerization interface [polypeptide binding]; other site
1163389003685	putative DNA binding site [nucleotide binding]; other site
1163389003686	putative Zn2+ binding site [ion binding]; other site
1163389003687	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1163389003688	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1163389003689	putative active site [active]
1163389003690	substrate binding site [chemical binding]; other site
1163389003691	putative cosubstrate binding site; other site
1163389003692	catalytic site [active]
1163389003693	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1163389003694	substrate binding site [chemical binding]; other site
1163389003695	glutathione synthetase; Provisional; Region: PRK05246
1163389003696	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1163389003697	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1163389003698	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1163389003699	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1163389003700	inhibitor-cofactor binding pocket; inhibition site
1163389003701	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389003702	catalytic residue [active]
1163389003703	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1163389003704	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1163389003705	Transcriptional regulator; Region: Rrf2; cl17282
1163389003706	Rrf2 family protein; Region: rrf2_super; TIGR00738
1163389003707	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1163389003708	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1163389003709	heme-binding site [chemical binding]; other site
1163389003710	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1163389003711	FAD binding pocket [chemical binding]; other site
1163389003712	FAD binding motif [chemical binding]; other site
1163389003713	phosphate binding motif [ion binding]; other site
1163389003714	beta-alpha-beta structure motif; other site
1163389003715	NAD binding pocket [chemical binding]; other site
1163389003716	Heme binding  pocket [chemical binding]; other site
1163389003717	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1163389003718	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1163389003719	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1163389003720	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1163389003721	nucleotide binding site [chemical binding]; other site
1163389003722	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1163389003723	dimerization interface [polypeptide binding]; other site
1163389003724	putative DNA binding site [nucleotide binding]; other site
1163389003725	putative Zn2+ binding site [ion binding]; other site
1163389003726	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1163389003727	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1163389003728	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1163389003729	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); Region: HPPK; pfam01288
1163389003730	catalytic center binding site [active]
1163389003731	ATP binding site [chemical binding]; other site
1163389003732	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1163389003733	dihydropteroate synthase; Region: DHPS; TIGR01496
1163389003734	substrate binding pocket [chemical binding]; other site
1163389003735	dimer interface [polypeptide binding]; other site
1163389003736	inhibitor binding site; inhibition site
1163389003737	Dihydroneopterin aldolase; Region: FolB; smart00905
1163389003738	active site
1163389003739	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1163389003740	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1163389003741	acyl-activating enzyme (AAE) consensus motif; other site
1163389003742	AMP binding site [chemical binding]; other site
1163389003743	active site
1163389003744	CoA binding site [chemical binding]; other site
1163389003745	aminodeoxychorismate synthase; Provisional; Region: PRK07508
1163389003746	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1163389003747	Aminotransferase class IV; Region: Aminotran_4; pfam01063
1163389003748	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1163389003749	substrate-cofactor binding pocket; other site
1163389003750	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389003751	catalytic residue [active]
1163389003752	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1163389003753	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1163389003754	glutamine binding [chemical binding]; other site
1163389003755	catalytic triad [active]
1163389003756	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
1163389003757	catalytic tetrad [active]
1163389003758	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1163389003759	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
1163389003760	active site
1163389003761	catalytic triad [active]
1163389003762	dimer interface [polypeptide binding]; other site
1163389003763	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1163389003764	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
1163389003765	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
1163389003766	active site
1163389003767	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
1163389003768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389003769	putative substrate translocation pore; other site
1163389003770	Uncharacterized conserved protein [Function unknown]; Region: COG0393
1163389003771	glutathione reductase; Validated; Region: PRK06116
1163389003772	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1163389003773	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1163389003774	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1163389003775	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
1163389003776	putative active site [active]
1163389003777	putative catalytic site [active]
1163389003778	putative DNA binding site [nucleotide binding]; other site
1163389003779	putative phosphate binding site [ion binding]; other site
1163389003780	metal binding site A [ion binding]; metal-binding site
1163389003781	putative AP binding site [nucleotide binding]; other site
1163389003782	putative metal binding site B [ion binding]; other site
1163389003783	potential frameshift: common BLAST hit: gi|337755356|ref|YP_004647867.1| succinylglutamate desuccinylase/aspartoacylase
1163389003784	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1163389003785	active site
1163389003786	Zn binding site [ion binding]; other site
1163389003787	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1163389003788	Bor protein; Region: Lambda_Bor; pfam06291
1163389003789	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
1163389003790	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1163389003791	signal recognition particle protein; Provisional; Region: PRK10867
1163389003792	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1163389003793	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1163389003794	P loop; other site
1163389003795	GTP binding site [chemical binding]; other site
1163389003796	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1163389003797	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1163389003798	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1163389003799	rRNA binding site [nucleotide binding]; other site
1163389003800	predicted 30S ribosome binding site; other site
1163389003801	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
1163389003802	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
1163389003803	TrkA-N domain; Region: TrkA_N; pfam02254
1163389003804	TrkA-C domain; Region: TrkA_C; pfam02080
1163389003805	TrkA-N domain; Region: TrkA_N; pfam02254
1163389003806	TrkA-C domain; Region: TrkA_C; pfam02080
1163389003807	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
1163389003808	Transcriptional regulator; Region: Rrf2; pfam02082
1163389003809	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
1163389003810	putative ABC transporter; Region: ycf24; CHL00085
1163389003811	FeS assembly ATPase SufC; Region: sufC; TIGR01978
1163389003812	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1163389003813	Walker A/P-loop; other site
1163389003814	ATP binding site [chemical binding]; other site
1163389003815	Q-loop/lid; other site
1163389003816	ABC transporter signature motif; other site
1163389003817	Walker B; other site
1163389003818	D-loop; other site
1163389003819	H-loop/switch region; other site
1163389003820	FeS assembly protein SufD; Region: sufD; TIGR01981
1163389003821	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
1163389003822	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1163389003823	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1163389003824	catalytic residues [active]
1163389003825	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
1163389003826	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1163389003827	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1163389003828	active site
1163389003829	8-oxo-dGMP binding site [chemical binding]; other site
1163389003830	nudix motif; other site
1163389003831	metal binding site [ion binding]; metal-binding site
1163389003832	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
1163389003833	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
1163389003834	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1163389003835	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1163389003836	HIGH motif; other site
1163389003837	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1163389003838	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1163389003839	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1163389003840	active site
1163389003841	KMSKS motif; other site
1163389003842	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1163389003843	tRNA binding surface [nucleotide binding]; other site
1163389003844	Lipopolysaccharide-assembly; Region: LptE; cl01125
1163389003845	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1163389003846	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1163389003847	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1163389003848	trimer interface [polypeptide binding]; other site
1163389003849	active site
1163389003850	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
1163389003851	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1163389003852	Walker A motif; other site
1163389003853	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1163389003854	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156
1163389003855	putative active site [active]
1163389003856	catalytic site [active]
1163389003857	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162
1163389003858	putative active site [active]
1163389003859	catalytic site [active]
1163389003860	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
1163389003861	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1163389003862	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1163389003863	metal binding site 2 [ion binding]; metal-binding site
1163389003864	putative DNA binding helix; other site
1163389003865	metal binding site 1 [ion binding]; metal-binding site
1163389003866	dimer interface [polypeptide binding]; other site
1163389003867	structural Zn2+ binding site [ion binding]; other site
1163389003868	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1163389003869	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1163389003870	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1163389003871	putative tRNA-binding site [nucleotide binding]; other site
1163389003872	B3/4 domain; Region: B3_4; pfam03483
1163389003873	tRNA synthetase B5 domain; Region: B5; smart00874
1163389003874	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1163389003875	dimer interface [polypeptide binding]; other site
1163389003876	motif 1; other site
1163389003877	motif 3; other site
1163389003878	motif 2; other site
1163389003879	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1163389003880	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1163389003881	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1163389003882	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1163389003883	dimer interface [polypeptide binding]; other site
1163389003884	motif 1; other site
1163389003885	active site
1163389003886	motif 2; other site
1163389003887	motif 3; other site
1163389003888	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1163389003889	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1163389003890	dimer interface [polypeptide binding]; other site
1163389003891	active site
1163389003892	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1163389003893	folate binding site [chemical binding]; other site
1163389003894	hypothetical protein; Provisional; Region: PRK05255
1163389003895	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
1163389003896	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1163389003897	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1163389003898	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1163389003899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389003900	POT family; Region: PTR2; cl17359
1163389003901	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1163389003902	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1163389003903	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
1163389003904	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
1163389003905	ligand binding site [chemical binding]; other site
1163389003906	NAD binding site [chemical binding]; other site
1163389003907	tetramer interface [polypeptide binding]; other site
1163389003908	catalytic site [active]
1163389003909	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1163389003910	L-serine binding site [chemical binding]; other site
1163389003911	ACT domain interface; other site
1163389003912	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1163389003913	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1163389003914	dimerization interface [polypeptide binding]; other site
1163389003915	active site
1163389003916	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1163389003917	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
1163389003918	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1163389003919	homodimer interface [polypeptide binding]; other site
1163389003920	oligonucleotide binding site [chemical binding]; other site
1163389003921	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1163389003922	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1163389003923	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1163389003924	catalytic residue [active]
1163389003925	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1163389003926	Recombination protein O N terminal; Region: RecO_N; pfam11967
1163389003927	Recombination protein O C terminal; Region: RecO_C; pfam02565
1163389003928	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1163389003929	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1163389003930	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1163389003931	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1163389003932	BolA-like protein; Region: BolA; cl00386
1163389003933	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
1163389003934	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
1163389003935	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1163389003936	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1163389003937	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1163389003938	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1163389003939	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1163389003940	active site
1163389003941	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1163389003942	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1163389003943	ATP binding site [chemical binding]; other site
1163389003944	putative Mg++ binding site [ion binding]; other site
1163389003945	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1163389003946	nucleotide binding region [chemical binding]; other site
1163389003947	ATP-binding site [chemical binding]; other site
1163389003948	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1163389003949	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1163389003950	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1163389003951	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
1163389003952	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1163389003953	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1163389003954	dimer interface [polypeptide binding]; other site
1163389003955	active site
1163389003956	metal binding site [ion binding]; metal-binding site
1163389003957	glutathione binding site [chemical binding]; other site
1163389003958	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1163389003959	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
1163389003960	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1163389003961	NAD binding site [chemical binding]; other site
1163389003962	homotetramer interface [polypeptide binding]; other site
1163389003963	homodimer interface [polypeptide binding]; other site
1163389003964	substrate binding site [chemical binding]; other site
1163389003965	active site
1163389003966	hypothetical protein; Provisional; Region: PRK05409
1163389003967	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
1163389003968	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1163389003969	putative active site [active]
1163389003970	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1163389003971	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1163389003972	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1163389003973	substrate binding site [chemical binding]; other site
1163389003974	hexamer interface [polypeptide binding]; other site
1163389003975	metal binding site [ion binding]; metal-binding site
1163389003976	UDP-glucose 4-epimerase; Region: PLN02240
1163389003977	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1163389003978	NAD binding site [chemical binding]; other site
1163389003979	homodimer interface [polypeptide binding]; other site
1163389003980	active site
1163389003981	substrate binding site [chemical binding]; other site
1163389003982	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1163389003983	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
1163389003984	putative ADP-binding pocket [chemical binding]; other site
1163389003985	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1163389003986	NAD(P) binding site [chemical binding]; other site
1163389003987	active site
1163389003988	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1163389003989	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1163389003990	inhibitor-cofactor binding pocket; inhibition site
1163389003991	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389003992	catalytic residue [active]
1163389003993	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1163389003994	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
1163389003995	ligand binding site; other site
1163389003996	tetramer interface; other site
1163389003997	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
1163389003998	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
1163389003999	pseudaminic acid synthase; Region: PseI; TIGR03586
1163389004000	NeuB family; Region: NeuB; pfam03102
1163389004001	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
1163389004002	NeuB binding interface [polypeptide binding]; other site
1163389004003	putative substrate binding site [chemical binding]; other site
1163389004004	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1163389004005	extended (e) SDRs; Region: SDR_e; cd08946
1163389004006	NAD(P) binding site [chemical binding]; other site
1163389004007	active site
1163389004008	substrate binding site [chemical binding]; other site
1163389004009	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1163389004010	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1163389004011	metal-binding site
1163389004012	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1163389004013	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1163389004014	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1163389004015	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
1163389004016	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1163389004017	motif II; other site
1163389004018	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1163389004019	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1163389004020	substrate binding site [chemical binding]; other site
1163389004021	ATP binding site [chemical binding]; other site
1163389004022	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
1163389004023	proposed catalytic triad [active]
1163389004024	active site nucleophile [active]
1163389004025	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
1163389004026	catalytic nucleophile [active]
1163389004027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389004028	metabolite-proton symporter; Region: 2A0106; TIGR00883
1163389004029	putative substrate translocation pore; other site
1163389004030	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
1163389004031	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1163389004032	Fungal protease inhibitor; Region: amfpi-1; pfam12190
1163389004033	poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011
1163389004034	poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332
1163389004035	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1163389004036	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1163389004037	Zn2+ binding site [ion binding]; other site
1163389004038	Mg2+ binding site [ion binding]; other site
1163389004039	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1163389004040	synthetase active site [active]
1163389004041	NTP binding site [chemical binding]; other site
1163389004042	metal binding site [ion binding]; metal-binding site
1163389004043	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1163389004044	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1163389004045	recombination protein RecR; Provisional; Region: PRK13844
1163389004046	RecR protein; Region: RecR; pfam02132
1163389004047	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1163389004048	putative active site [active]
1163389004049	putative metal-binding site [ion binding]; other site
1163389004050	tetramer interface [polypeptide binding]; other site
1163389004051	hypothetical protein; Validated; Region: PRK00153
1163389004052	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1163389004053	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1163389004054	homodimer interface [polypeptide binding]; other site
1163389004055	active site
1163389004056	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1163389004057	lipoyl attachment site [posttranslational modification]; other site
1163389004058	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1163389004059	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1163389004060	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1163389004061	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1163389004062	active site
1163389004063	dimer interface [polypeptide binding]; other site
1163389004064	motif 1; other site
1163389004065	motif 2; other site
1163389004066	motif 3; other site
1163389004067	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1163389004068	anticodon binding site; other site
1163389004069	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1163389004070	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1163389004071	23S rRNA binding site [nucleotide binding]; other site
1163389004072	L21 binding site [polypeptide binding]; other site
1163389004073	L13 binding site [polypeptide binding]; other site
1163389004074	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1163389004075	Pirin-related protein [General function prediction only]; Region: COG1741
1163389004076	Pirin; Region: Pirin; pfam02678
1163389004077	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1163389004078	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1163389004079	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1163389004080	active site
1163389004081	dimer interface [polypeptide binding]; other site
1163389004082	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1163389004083	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1163389004084	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1163389004085	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1163389004086	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1163389004087	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1163389004088	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1163389004089	putative effector binding pocket; other site
1163389004090	dimerization interface [polypeptide binding]; other site
1163389004091	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1163389004092	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1163389004093	NAD(P) binding site [chemical binding]; other site
1163389004094	active site
1163389004095	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
1163389004096	active site
1163389004097	catalytic site [active]
1163389004098	substrate binding site [chemical binding]; other site
1163389004099	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
1163389004100	excinuclease ABC subunit B; Provisional; Region: PRK05298
1163389004101	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1163389004102	ATP binding site [chemical binding]; other site
1163389004103	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1163389004104	nucleotide binding region [chemical binding]; other site
1163389004105	ATP-binding site [chemical binding]; other site
1163389004106	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1163389004107	UvrB/uvrC motif; Region: UVR; pfam02151
1163389004108	Nuclease-related domain; Region: NERD; pfam08378
1163389004109	glutamate racemase; Provisional; Region: PRK00865
1163389004110	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389004111	metabolite-proton symporter; Region: 2A0106; TIGR00883
1163389004112	putative substrate translocation pore; other site
1163389004113	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1163389004114	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1163389004115	metal binding site [ion binding]; metal-binding site
1163389004116	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1163389004117	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1163389004118	generic binding surface II; other site
1163389004119	generic binding surface I; other site
1163389004120	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1163389004121	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1163389004122	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1163389004123	metal binding site [ion binding]; metal-binding site
1163389004124	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1163389004125	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1163389004126	catalytic residue [active]
1163389004127	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1163389004128	Ligand Binding Site [chemical binding]; other site
1163389004129	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1163389004130	SmpB-tmRNA interface; other site
1163389004131	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1163389004132	putative coenzyme Q binding site [chemical binding]; other site
1163389004133	hypothetical protein; Validated; Region: PRK01777
1163389004134	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1163389004135	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
1163389004136	VacJ like lipoprotein; Region: VacJ; cl01073
1163389004137	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1163389004138	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1163389004139	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1163389004140	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1163389004141	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1163389004142	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1163389004143	G1 box; other site
1163389004144	putative GEF interaction site [polypeptide binding]; other site
1163389004145	GTP/Mg2+ binding site [chemical binding]; other site
1163389004146	Switch I region; other site
1163389004147	G2 box; other site
1163389004148	G3 box; other site
1163389004149	Switch II region; other site
1163389004150	G4 box; other site
1163389004151	G5 box; other site
1163389004152	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1163389004153	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1163389004154	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
1163389004155	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1163389004156	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1163389004157	catalytic residue [active]
1163389004158	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1163389004159	Rubredoxin; Region: Rubredoxin; pfam00301
1163389004160	iron binding site [ion binding]; other site
1163389004161	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1163389004162	hypothetical protein; Validated; Region: PRK00029
1163389004163	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1163389004164	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1163389004165	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1163389004166	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1163389004167	dimer interface [polypeptide binding]; other site
1163389004168	active site
1163389004169	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1163389004170	dimer interface [polypeptide binding]; other site
1163389004171	active site
1163389004172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389004173	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1163389004174	putative substrate translocation pore; other site
1163389004175	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389004176	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1163389004177	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
1163389004178	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1163389004179	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1163389004180	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1163389004181	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1163389004182	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1163389004183	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1163389004184	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1163389004185	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
1163389004186	active site
1163389004187	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
1163389004188	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1163389004189	active site
1163389004190	substrate binding site [chemical binding]; other site
1163389004191	Mg2+ binding site [ion binding]; other site
1163389004192	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1163389004193	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1163389004194	putative active site [active]
1163389004195	catalytic triad [active]
1163389004196	putative dimer interface [polypeptide binding]; other site
1163389004197	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1163389004198	Transporter associated domain; Region: CorC_HlyC; smart01091
1163389004199	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
1163389004200	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
1163389004201	dimer interface [polypeptide binding]; other site
1163389004202	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1163389004203	metal binding site [ion binding]; metal-binding site
1163389004204	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1163389004205	PhoH-like protein; Region: PhoH; pfam02562
1163389004206	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1163389004207	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1163389004208	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1163389004209	FeS/SAM binding site; other site
1163389004210	TRAM domain; Region: TRAM; pfam01938
1163389004211	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1163389004212	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1163389004213	thymidine kinase; Provisional; Region: PRK04296
1163389004214	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1163389004215	Sel1-like repeats; Region: SEL1; smart00671
1163389004216	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
1163389004217	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1163389004218	GTP/Mg2+ binding site [chemical binding]; other site
1163389004219	G4 box; other site
1163389004220	G5 box; other site
1163389004221	G1 box; other site
1163389004222	Switch I region; other site
1163389004223	G2 box; other site
1163389004224	G3 box; other site
1163389004225	Switch II region; other site
1163389004226	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1163389004227	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1163389004228	active site
1163389004229	dimer interface [polypeptide binding]; other site
1163389004230	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1163389004231	Glycoprotease family; Region: Peptidase_M22; pfam00814
1163389004232	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1163389004233	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1163389004234	putative active site [active]
1163389004235	putative dimer interface [polypeptide binding]; other site
1163389004236	aspartate aminotransferase; Provisional; Region: PRK05764
1163389004237	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1163389004238	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1163389004239	homodimer interface [polypeptide binding]; other site
1163389004240	catalytic residue [active]
1163389004241	GTPase Era; Reviewed; Region: era; PRK00089
1163389004242	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1163389004243	G1 box; other site
1163389004244	GTP/Mg2+ binding site [chemical binding]; other site
1163389004245	Switch I region; other site
1163389004246	G2 box; other site
1163389004247	Switch II region; other site
1163389004248	G3 box; other site
1163389004249	G4 box; other site
1163389004250	G5 box; other site
1163389004251	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1163389004252	FAD binding domain; Region: FAD_binding_4; pfam01565
1163389004253	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1163389004254	Cysteine-rich domain; Region: CCG; pfam02754
1163389004255	adenylate kinase; Reviewed; Region: adk; PRK00279
1163389004256	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1163389004257	AMP-binding site [chemical binding]; other site
1163389004258	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1163389004259	shikimate kinase; Reviewed; Region: aroK; PRK00131
1163389004260	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1163389004261	ADP binding site [chemical binding]; other site
1163389004262	magnesium binding site [ion binding]; other site
1163389004263	putative shikimate binding site; other site
1163389004264	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1163389004265	active site
1163389004266	dimer interface [polypeptide binding]; other site
1163389004267	metal binding site [ion binding]; metal-binding site
1163389004268	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
1163389004269	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
1163389004270	Proline dehydrogenase; Region: Pro_dh; pfam01619
1163389004271	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1163389004272	Glutamate binding site [chemical binding]; other site
1163389004273	NAD binding site [chemical binding]; other site
1163389004274	catalytic residues [active]
1163389004275	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1163389004276	NAD(P) binding site [chemical binding]; other site
1163389004277	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1163389004278	benzoate transport; Region: 2A0115; TIGR00895
1163389004279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1163389004280	putative substrate translocation pore; other site
1163389004281	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1163389004282	Flavoprotein; Region: Flavoprotein; pfam02441
1163389004283	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1163389004284	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1163389004285	DNA photolyase; Region: DNA_photolyase; pfam00875
1163389004286	ferrochelatase; Reviewed; Region: hemH; PRK00035
1163389004287	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1163389004288	C-terminal domain interface [polypeptide binding]; other site
1163389004289	active site
1163389004290	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1163389004291	active site
1163389004292	N-terminal domain interface [polypeptide binding]; other site
1163389004293	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
1163389004294	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
1163389004295	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1163389004296	S-adenosylmethionine binding site [chemical binding]; other site
1163389004297	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1163389004298	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1163389004299	FMN binding site [chemical binding]; other site
1163389004300	active site
1163389004301	catalytic residues [active]
1163389004302	substrate binding site [chemical binding]; other site
1163389004303	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1163389004304	active site
1163389004305	DNA polymerase IV; Validated; Region: PRK02406
1163389004306	DNA binding site [nucleotide binding]
1163389004307	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1163389004308	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
1163389004309	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1163389004310	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1163389004311	ABC transporter; Region: ABC_tran_2; pfam12848
1163389004312	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1163389004313	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1163389004314	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389004315	Beta-lactamase; Region: Beta-lactamase; cl17358
1163389004316	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1163389004317	bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759
1163389004318	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1163389004319	GSH binding site [chemical binding]; other site
1163389004320	catalytic residues [active]
1163389004321	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1163389004322	dimer interface [polypeptide binding]; other site
1163389004323	putative radical transfer pathway; other site
1163389004324	diiron center [ion binding]; other site
1163389004325	tyrosyl radical; other site
1163389004326	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
1163389004327	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1163389004328	active site
1163389004329	dimer interface [polypeptide binding]; other site
1163389004330	catalytic residues [active]
1163389004331	effector binding site; other site
1163389004332	R2 peptide binding site; other site
1163389004333	malate dehydrogenase; Reviewed; Region: PRK06223
1163389004334	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
1163389004335	NAD(P) binding site [chemical binding]; other site
1163389004336	dimer interface [polypeptide binding]; other site
1163389004337	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1163389004338	substrate binding site [chemical binding]; other site
1163389004339	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
1163389004340	diiron binding motif [ion binding]; other site
1163389004341	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1163389004342	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389004343	putative substrate translocation pore; other site
1163389004344	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
1163389004345	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1163389004346	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1163389004347	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1163389004348	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1163389004349	Amino acid permease; Region: AA_permease_2; pfam13520
1163389004350	GTPase CgtA; Reviewed; Region: obgE; PRK12299
1163389004351	GTP1/OBG; Region: GTP1_OBG; pfam01018
1163389004352	Obg GTPase; Region: Obg; cd01898
1163389004353	G1 box; other site
1163389004354	GTP/Mg2+ binding site [chemical binding]; other site
1163389004355	Switch I region; other site
1163389004356	G2 box; other site
1163389004357	G3 box; other site
1163389004358	Switch II region; other site
1163389004359	G4 box; other site
1163389004360	G5 box; other site
1163389004361	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1163389004362	aromatic amino acid transport protein; Region: araaP; TIGR00837
1163389004363	K+-transporting ATPase, c chain; Region: KdpC; cl00944
1163389004364	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1163389004365	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
1163389004366	Predicted transcriptional regulators [Transcription]; Region: COG1733
1163389004367	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1163389004368	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1163389004369	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
1163389004370	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1163389004371	putative substrate translocation pore; other site
1163389004372	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1163389004373	nucleotide binding site [chemical binding]; other site
1163389004374	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932
1163389004375	lysine allosteric regulatory site; other site
1163389004376	dimer interface [polypeptide binding]; other site
1163389004377	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1163389004378	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1163389004379	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1163389004380	active site
1163389004381	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1163389004382	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
1163389004383	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
1163389004384	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
1163389004385	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1163389004386	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1163389004387	Cl- selectivity filter; other site
1163389004388	Cl- binding residues [ion binding]; other site
1163389004389	pore gating glutamate residue; other site
1163389004390	dimer interface [polypeptide binding]; other site
1163389004391	H+/Cl- coupling transport residue; other site
1163389004392	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1163389004393	catalytic residue [active]
1163389004394	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1163389004395	heterodimer interface [polypeptide binding]; other site
1163389004396	substrate binding site [chemical binding]; other site
1163389004397	active site
1163389004398	catalytic residues [active]
1163389004399	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1163389004400	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1163389004401	Clp amino terminal domain; Region: Clp_N; pfam02861
1163389004402	Clp amino terminal domain; Region: Clp_N; pfam02861
1163389004403	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1163389004404	Walker A motif; other site
1163389004405	ATP binding site [chemical binding]; other site
1163389004406	Walker B motif; other site
1163389004407	arginine finger; other site
1163389004408	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1163389004409	Walker A motif; other site
1163389004410	ATP binding site [chemical binding]; other site
1163389004411	Walker B motif; other site
1163389004412	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1163389004413	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1163389004414	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1163389004415	ATP-grasp domain; Region: ATP-grasp; pfam02222
1163389004416	Frag1/DRAM/Sfk1 family; Region: Frag1; pfam10277
1163389004417	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1163389004418	4Fe-4S binding domain; Region: Fer4; cl02805
1163389004419	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
1163389004420	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1163389004421	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1163389004422	putative acyl-acceptor binding pocket; other site
1163389004423	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1163389004424	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1163389004425	putative acyl-acceptor binding pocket; other site
1163389004426	hypothetical protein; Provisional; Region: PRK05421
1163389004427	putative catalytic site [active]
1163389004428	putative metal binding site [ion binding]; other site
1163389004429	putative phosphate binding site [ion binding]; other site
1163389004430	putative catalytic site [active]
1163389004431	putative phosphate binding site [ion binding]; other site
1163389004432	putative metal binding site [ion binding]; other site
1163389004433	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854
1163389004434	potential frameshift: common BLAST hit: gi|187930971|ref|YP_001890955.1| rieske protein
1163389004435	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1163389004436	iron-sulfur cluster [ion binding]; other site
1163389004437	[2Fe-2S] cluster binding site [ion binding]; other site
1163389004438	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1163389004439	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1163389004440	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1163389004441	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1163389004442	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
1163389004443	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1163389004444	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1163389004445	catalytic triad [active]
1163389004446	HupF/HypC family; Region: HupF_HypC; cl00394
1163389004447	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
1163389004448	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1163389004449	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1163389004450	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1163389004451	Walker A/P-loop; other site
1163389004452	ATP binding site [chemical binding]; other site
1163389004453	Q-loop/lid; other site
1163389004454	ABC transporter signature motif; other site
1163389004455	Walker B; other site
1163389004456	D-loop; other site
1163389004457	H-loop/switch region; other site
1163389004458	ABC transporter; Region: ABC_tran_2; pfam12848
1163389004459	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1163389004460	potential frameshift: common BLAST hit: gi|134302785|ref|YP_001122753.1| major facilitator transporter
1163389004461	metabolite-proton symporter; Region: 2A0106; TIGR00883
1163389004462	potential frameshift: common BLAST hit: gi|167627047|ref|YP_001677547.1| metabolite:H+ symporter (MHS) family protein
1163389004463	citrate-proton symporter; Provisional; Region: PRK15075
1163389004464	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1163389004465	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1163389004466	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1163389004467	Ureide permease; Region: Ureide_permease; pfam07168
1163389004468	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1163389004469	active site
1163389004470	ribulose/triose binding site [chemical binding]; other site
1163389004471	substrate (anthranilate) binding pocket [chemical binding]; other site
1163389004472	product (indole) binding pocket [chemical binding]; other site
1163389004473	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1163389004474	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
1163389004475	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1163389004476	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1163389004477	glutamine binding [chemical binding]; other site
1163389004478	catalytic triad [active]
1163389004479	ribonuclease G; Provisional; Region: PRK11712
1163389004480	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1163389004481	homodimer interface [polypeptide binding]; other site
1163389004482	oligonucleotide binding site [chemical binding]; other site