-- dump date 20140619_095005 -- class Genbank::misc_feature -- table misc_feature_note -- id note 401614000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 401614000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 401614000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614000004 Walker A motif; other site 401614000005 ATP binding site [chemical binding]; other site 401614000006 Walker B motif; other site 401614000007 arginine finger; other site 401614000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 401614000009 DnaA box-binding interface [nucleotide binding]; other site 401614000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 401614000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 401614000012 putative DNA binding surface [nucleotide binding]; other site 401614000013 dimer interface [polypeptide binding]; other site 401614000014 beta-clamp/clamp loader binding surface; other site 401614000015 beta-clamp/translesion DNA polymerase binding surface; other site 401614000016 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614000017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000018 putative substrate translocation pore; other site 401614000019 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 401614000020 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 401614000021 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 401614000022 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 401614000023 Cl binding site [ion binding]; other site 401614000024 oligomer interface [polypeptide binding]; other site 401614000025 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 401614000026 EamA-like transporter family; Region: EamA; pfam00892 401614000027 Terminase small subunit; Region: Terminase_2; cl01513 401614000028 AAA domain; Region: AAA_25; pfam13481 401614000029 Walker A motif; other site 401614000030 ATP binding site [chemical binding]; other site 401614000031 Walker B motif; other site 401614000032 Homeodomain-like domain; Region: HTH_23; pfam13384 401614000033 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 401614000034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 401614000035 Toprim domain; Region: Toprim_3; pfam13362 401614000036 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 401614000037 integrase; Provisional; Region: PRK09692 401614000038 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 401614000039 active site 401614000040 DNA binding site [nucleotide binding] 401614000041 Int/Topo IB signature motif; other site 401614000042 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 401614000043 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 401614000044 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 401614000045 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 401614000046 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 401614000047 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 401614000048 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 401614000049 ATP-grasp domain; Region: ATP-grasp_4; cl17255 401614000050 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 401614000051 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 401614000052 ATP-grasp domain; Region: ATP-grasp_4; cl17255 401614000053 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 401614000054 substrate binding site [chemical binding]; other site 401614000055 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 401614000056 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 401614000057 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 401614000058 catalytic site [active] 401614000059 subunit interface [polypeptide binding]; other site 401614000060 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 401614000061 catalytic core [active] 401614000062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614000063 S-adenosylmethionine binding site [chemical binding]; other site 401614000064 dihydroorotase; Reviewed; Region: PRK09236 401614000065 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 401614000066 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 401614000067 active site 401614000068 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 401614000069 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 401614000070 HlyD family secretion protein; Region: HlyD; pfam00529 401614000071 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 401614000072 HlyD family secretion protein; Region: HlyD_3; pfam13437 401614000073 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 401614000074 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614000075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 401614000076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 401614000077 dimerization interface [polypeptide binding]; other site 401614000078 SOUL heme-binding protein; Region: SOUL; pfam04832 401614000079 Chorismate mutase type II; Region: CM_2; smart00830 401614000080 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 401614000081 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 401614000082 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 401614000083 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 401614000084 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 401614000085 active site 401614000086 dimer interface [polypeptide binding]; other site 401614000087 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 401614000088 phosphate binding site [ion binding]; other site 401614000089 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 401614000090 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 401614000091 Protein of unknown function (DUF770); Region: DUF770; pfam05591 401614000092 Protein of unknown function (DUF877); Region: DUF877; pfam05943 401614000093 Poxvirus nucleic acid binding protein VP8/L4R; Region: Pox_VP8_L4R; pfam04498 401614000094 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 401614000095 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 401614000096 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 401614000097 Phosphoesterase family; Region: Phosphoesterase; pfam04185 401614000098 Synaptonemal complex protein 1 (SCP-1); Region: SCP-1; pfam05483 401614000099 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 401614000100 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 401614000101 prephenate dehydrogenase; Validated; Region: PRK08507 401614000102 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 401614000103 putative active site [active] 401614000104 dimerization interface [polypeptide binding]; other site 401614000105 putative tRNAtyr binding site [nucleotide binding]; other site 401614000106 putative transporter; Provisional; Region: PRK03699 401614000107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000108 putative substrate translocation pore; other site 401614000109 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 401614000110 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 401614000111 substrate binding [chemical binding]; other site 401614000112 active site 401614000113 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 401614000114 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 401614000115 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 401614000116 substrate binding site [chemical binding]; other site 401614000117 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 401614000118 substrate binding site [chemical binding]; other site 401614000119 ligand binding site [chemical binding]; other site 401614000120 2-isopropylmalate synthase; Validated; Region: PRK00915 401614000121 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 401614000122 active site 401614000123 catalytic residues [active] 401614000124 metal binding site [ion binding]; metal-binding site 401614000125 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 401614000126 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 401614000127 homodimer interface [polypeptide binding]; other site 401614000128 substrate-cofactor binding pocket; other site 401614000129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614000130 catalytic residue [active] 401614000131 pyruvate phosphate dikinase; Provisional; Region: PRK09279 401614000132 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 401614000133 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 401614000134 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 401614000135 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 401614000136 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 401614000137 G1 box; other site 401614000138 GTP/Mg2+ binding site [chemical binding]; other site 401614000139 Switch I region; other site 401614000140 G2 box; other site 401614000141 G3 box; other site 401614000142 Switch II region; other site 401614000143 G4 box; other site 401614000144 G5 box; other site 401614000145 Nucleoside recognition; Region: Gate; pfam07670 401614000146 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 401614000147 Nucleoside recognition; Region: Gate; pfam07670 401614000148 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 401614000149 catalytic site [active] 401614000150 putative active site [active] 401614000151 putative substrate binding site [chemical binding]; other site 401614000152 dimer interface [polypeptide binding]; other site 401614000153 elongation factor P; Validated; Region: PRK00529 401614000154 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 401614000155 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 401614000156 RNA binding site [nucleotide binding]; other site 401614000157 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 401614000158 RNA binding site [nucleotide binding]; other site 401614000159 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 401614000160 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 401614000161 putative acyl-acceptor binding pocket; other site 401614000162 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 401614000163 putative acyl-acceptor binding pocket; other site 401614000164 membrane protein insertase; Provisional; Region: PRK01318 401614000165 YidC periplasmic domain; Region: YidC_periplas; pfam14849 401614000166 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 401614000167 hypothetical protein; Provisional; Region: PRK14375 401614000168 Ribonuclease P; Region: Ribonuclease_P; pfam00825 401614000169 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 401614000170 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 401614000171 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 401614000172 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 401614000173 NAD(P) binding pocket [chemical binding]; other site 401614000174 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 401614000175 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 401614000176 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614000177 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401614000178 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 401614000179 putative SAM binding site [chemical binding]; other site 401614000180 putative homodimer interface [polypeptide binding]; other site 401614000181 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 401614000182 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 401614000183 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 401614000184 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 401614000185 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 401614000186 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 401614000187 PLD-like domain; Region: PLDc_2; pfam13091 401614000188 putative homodimer interface [polypeptide binding]; other site 401614000189 putative active site [active] 401614000190 catalytic site [active] 401614000191 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 401614000192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614000193 ATP binding site [chemical binding]; other site 401614000194 putative Mg++ binding site [ion binding]; other site 401614000195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614000196 nucleotide binding region [chemical binding]; other site 401614000197 ATP-binding site [chemical binding]; other site 401614000198 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 401614000199 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 401614000200 Ligand Binding Site [chemical binding]; other site 401614000201 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 401614000202 Ligand Binding Site [chemical binding]; other site 401614000203 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614000204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000205 putative substrate translocation pore; other site 401614000206 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 401614000207 LamB/YcsF family protein; Provisional; Region: PRK05406 401614000208 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 401614000209 Phosphoesterase family; Region: Phosphoesterase; pfam04185 401614000210 Phosphate transporter family; Region: PHO4; pfam01384 401614000211 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 401614000212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614000213 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 401614000214 putative FMN binding site [chemical binding]; other site 401614000215 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 401614000216 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 401614000217 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 401614000218 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 401614000219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614000220 S-adenosylmethionine binding site [chemical binding]; other site 401614000221 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 401614000222 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401614000223 catalytic residue [active] 401614000224 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 401614000225 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614000226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 401614000227 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 401614000228 putative effector binding pocket; other site 401614000229 dimerization interface [polypeptide binding]; other site 401614000230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000231 putative substrate translocation pore; other site 401614000232 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 401614000233 Glycosyl hydrolases related to GH101 family, GHL1-GHL3; Region: GHL1-3; pfam11308 401614000234 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 401614000235 dimer interface [polypeptide binding]; other site 401614000236 active site 401614000237 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 401614000238 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 401614000239 GTP-binding protein LepA; Provisional; Region: PRK05433 401614000240 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 401614000241 G1 box; other site 401614000242 putative GEF interaction site [polypeptide binding]; other site 401614000243 GTP/Mg2+ binding site [chemical binding]; other site 401614000244 Switch I region; other site 401614000245 G2 box; other site 401614000246 G3 box; other site 401614000247 Switch II region; other site 401614000248 G4 box; other site 401614000249 G5 box; other site 401614000250 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 401614000251 Elongation Factor G, domain II; Region: EFG_II; pfam14492 401614000252 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 401614000253 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 401614000254 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 401614000255 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 401614000256 Ligand Binding Site [chemical binding]; other site 401614000257 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 401614000258 active site 401614000259 catalytic residues [active] 401614000260 metal binding site [ion binding]; metal-binding site 401614000261 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 401614000262 homopentamer interface [polypeptide binding]; other site 401614000263 active site 401614000264 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 401614000265 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 401614000266 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 401614000267 dimerization interface [polypeptide binding]; other site 401614000268 active site 401614000269 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 401614000270 Lumazine binding domain; Region: Lum_binding; pfam00677 401614000271 Lumazine binding domain; Region: Lum_binding; pfam00677 401614000272 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 401614000273 catalytic motif [active] 401614000274 Zn binding site [ion binding]; other site 401614000275 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 401614000276 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 401614000277 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 401614000278 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 401614000279 dimer interface [polypeptide binding]; other site 401614000280 PYR/PP interface [polypeptide binding]; other site 401614000281 TPP binding site [chemical binding]; other site 401614000282 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 401614000283 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 401614000284 TPP-binding site [chemical binding]; other site 401614000285 dimer interface [polypeptide binding]; other site 401614000286 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 401614000287 dimer interface [polypeptide binding]; other site 401614000288 [2Fe-2S] cluster binding site [ion binding]; other site 401614000289 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 401614000290 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 401614000291 tandem repeat interface [polypeptide binding]; other site 401614000292 oligomer interface [polypeptide binding]; other site 401614000293 active site residues [active] 401614000294 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 401614000295 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 401614000296 preprotein translocase subunit SecB; Provisional; Region: PRK13031 401614000297 SecA binding site; other site 401614000298 Preprotein binding site; other site 401614000299 recombinase A; Provisional; Region: recA; PRK09354 401614000300 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 401614000301 hexamer interface [polypeptide binding]; other site 401614000302 Walker A motif; other site 401614000303 ATP binding site [chemical binding]; other site 401614000304 Walker B motif; other site 401614000305 recombination regulator RecX; Reviewed; Region: recX; PRK00117 401614000306 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 401614000307 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 401614000308 dimer interface [polypeptide binding]; other site 401614000309 ssDNA binding site [nucleotide binding]; other site 401614000310 tetramer (dimer of dimers) interface [polypeptide binding]; other site 401614000311 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 401614000312 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401614000313 phosphate acetyltransferase; Reviewed; Region: PRK05632 401614000314 DRTGG domain; Region: DRTGG; pfam07085 401614000315 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 401614000316 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 401614000317 tetramerization interface [polypeptide binding]; other site 401614000318 NAD(P) binding site [chemical binding]; other site 401614000319 catalytic residues [active] 401614000320 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614000321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000322 putative substrate translocation pore; other site 401614000323 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 401614000324 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 401614000325 dimer interface [polypeptide binding]; other site 401614000326 anticodon binding site; other site 401614000327 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 401614000328 homodimer interface [polypeptide binding]; other site 401614000329 motif 1; other site 401614000330 active site 401614000331 motif 2; other site 401614000332 GAD domain; Region: GAD; pfam02938 401614000333 motif 3; other site 401614000334 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 401614000335 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401614000336 putative ADP-binding pocket [chemical binding]; other site 401614000337 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 401614000338 RNB domain; Region: RNB; pfam00773 401614000339 Predicted esterase [General function prediction only]; Region: COG0400 401614000340 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 401614000341 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 401614000342 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 401614000343 domain interfaces; other site 401614000344 active site 401614000345 camphor resistance protein CrcB; Provisional; Region: PRK14226 401614000346 Zinc-finger domain; Region: zf-CHCC; cl01821 401614000347 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 401614000348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614000349 dimer interface [polypeptide binding]; other site 401614000350 conserved gate region; other site 401614000351 putative PBP binding loops; other site 401614000352 ABC-ATPase subunit interface; other site 401614000353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614000354 dimer interface [polypeptide binding]; other site 401614000355 conserved gate region; other site 401614000356 putative PBP binding loops; other site 401614000357 ABC-ATPase subunit interface; other site 401614000358 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 401614000359 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 401614000360 Walker A/P-loop; other site 401614000361 ATP binding site [chemical binding]; other site 401614000362 Q-loop/lid; other site 401614000363 ABC transporter signature motif; other site 401614000364 Walker B; other site 401614000365 D-loop; other site 401614000366 H-loop/switch region; other site 401614000367 C-terminal AAA-associated domain; Region: AAA_assoc_C; pfam09821 401614000368 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 401614000369 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 401614000370 TrkA-N domain; Region: TrkA_N; pfam02254 401614000371 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 401614000372 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 401614000373 trimer interface [polypeptide binding]; other site 401614000374 putative metal binding site [ion binding]; other site 401614000375 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 401614000376 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 401614000377 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 401614000378 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 401614000379 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 401614000380 putative active site [active] 401614000381 Zn binding site [ion binding]; other site 401614000382 YGGT family; Region: YGGT; pfam02325 401614000383 YGGT family; Region: YGGT; pfam02325 401614000384 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 401614000385 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 401614000386 Walker A/P-loop; other site 401614000387 ATP binding site [chemical binding]; other site 401614000388 Q-loop/lid; other site 401614000389 ABC transporter signature motif; other site 401614000390 Walker B; other site 401614000391 D-loop; other site 401614000392 H-loop/switch region; other site 401614000393 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 401614000394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614000395 dimer interface [polypeptide binding]; other site 401614000396 conserved gate region; other site 401614000397 putative PBP binding loops; other site 401614000398 ABC-ATPase subunit interface; other site 401614000399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614000400 dimer interface [polypeptide binding]; other site 401614000401 conserved gate region; other site 401614000402 putative PBP binding loops; other site 401614000403 ABC-ATPase subunit interface; other site 401614000404 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 401614000405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 401614000406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 401614000407 Coenzyme A binding pocket [chemical binding]; other site 401614000408 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 401614000409 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 401614000410 ATP-grasp domain; Region: ATP-grasp_4; cl17255 401614000411 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 401614000412 Competence protein; Region: Competence; pfam03772 401614000413 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 401614000414 putative acyl-acceptor binding pocket; other site 401614000415 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 401614000416 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 401614000417 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 401614000418 RNA binding site [nucleotide binding]; other site 401614000419 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 401614000420 RNA binding site [nucleotide binding]; other site 401614000421 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 401614000422 RNA binding site [nucleotide binding]; other site 401614000423 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 401614000424 RNA binding site [nucleotide binding]; other site 401614000425 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 401614000426 RNA binding site [nucleotide binding]; other site 401614000427 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 401614000428 RNA binding site [nucleotide binding]; other site 401614000429 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 401614000430 nucleoside/Zn binding site; other site 401614000431 dimer interface [polypeptide binding]; other site 401614000432 catalytic motif [active] 401614000433 D-alanyl-alanine synthetase A; Provisional; Region: PRK14569 401614000434 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 401614000435 ATP-grasp domain; Region: ATP-grasp_4; cl17255 401614000436 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 401614000437 Cell division protein FtsQ; Region: FtsQ; pfam03799 401614000438 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 401614000439 Cell division protein FtsA; Region: FtsA; smart00842 401614000440 Cell division protein FtsA; Region: FtsA; pfam14450 401614000441 cell division protein FtsZ; Validated; Region: PRK09330 401614000442 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 401614000443 nucleotide binding site [chemical binding]; other site 401614000444 SulA interaction site; other site 401614000445 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 401614000446 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 401614000447 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 401614000448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614000449 Walker A motif; other site 401614000450 ATP binding site [chemical binding]; other site 401614000451 Walker B motif; other site 401614000452 DNA polymerase III subunit delta'; Validated; Region: PRK08485 401614000453 arginine finger; other site 401614000454 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 401614000455 This domain is found in peptide chain release factors; Region: PCRF; smart00937 401614000456 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 401614000457 RF-1 domain; Region: RF-1; pfam00472 401614000458 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 401614000459 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 401614000460 dimer interface [polypeptide binding]; other site 401614000461 putative anticodon binding site; other site 401614000462 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 401614000463 motif 1; other site 401614000464 active site 401614000465 motif 2; other site 401614000466 motif 3; other site 401614000467 hypothetical protein; Provisional; Region: PRK05208 401614000468 CAAX protease self-immunity; Region: Abi; pfam02517 401614000469 Eps15 homology domain; Region: EH; smart00027 401614000470 Glutaminase; Region: Glutaminase; cl00907 401614000471 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 401614000472 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 401614000473 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 401614000474 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 401614000475 glutamine synthetase; Region: PLN02284 401614000476 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 401614000477 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 401614000478 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 401614000479 Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840 401614000480 Lipocalin-like domain; Region: Lipocalin_2; cl19222 401614000481 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 401614000482 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 401614000483 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 401614000484 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 401614000485 purine monophosphate binding site [chemical binding]; other site 401614000486 dimer interface [polypeptide binding]; other site 401614000487 putative catalytic residues [active] 401614000488 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 401614000489 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 401614000490 GDP-binding site [chemical binding]; other site 401614000491 ACT binding site; other site 401614000492 IMP binding site; other site 401614000493 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401614000494 active site 401614000495 Dienelactone hydrolase family; Region: DLH; pfam01738 401614000496 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 401614000497 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 401614000498 ABC-ATPase subunit interface; other site 401614000499 dimer interface [polypeptide binding]; other site 401614000500 putative PBP binding regions; other site 401614000501 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 401614000502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401614000503 Walker A/P-loop; other site 401614000504 ATP binding site [chemical binding]; other site 401614000505 Q-loop/lid; other site 401614000506 ABC transporter signature motif; other site 401614000507 Walker B; other site 401614000508 D-loop; other site 401614000509 H-loop/switch region; other site 401614000510 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 401614000511 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 401614000512 intersubunit interface [polypeptide binding]; other site 401614000513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614000515 putative substrate translocation pore; other site 401614000516 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 401614000517 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 401614000518 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 401614000519 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 401614000520 primosome assembly protein PriA; Validated; Region: PRK05580 401614000521 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614000522 ATP binding site [chemical binding]; other site 401614000523 putative Mg++ binding site [ion binding]; other site 401614000524 helicase superfamily c-terminal domain; Region: HELICc; smart00490 401614000525 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 401614000526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000527 putative substrate translocation pore; other site 401614000528 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 401614000529 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 401614000530 substrate binding pocket [chemical binding]; other site 401614000531 membrane-bound complex binding site; other site 401614000532 hinge residues; other site 401614000533 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 401614000534 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 401614000535 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 401614000536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000537 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614000538 putative substrate translocation pore; other site 401614000539 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 401614000540 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 401614000541 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 401614000542 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 401614000543 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 401614000544 D-pathway; other site 401614000545 Putative ubiquinol binding site [chemical binding]; other site 401614000546 Low-spin heme (heme b) binding site [chemical binding]; other site 401614000547 Putative water exit pathway; other site 401614000548 Binuclear center (heme o3/CuB) [ion binding]; other site 401614000549 K-pathway; other site 401614000550 Putative proton exit pathway; other site 401614000551 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 401614000552 Subunit I/III interface [polypeptide binding]; other site 401614000553 Subunit III/IV interface [polypeptide binding]; other site 401614000554 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 401614000555 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 401614000556 putative active site [active] 401614000557 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 401614000558 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 401614000559 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 401614000560 trimer interface [polypeptide binding]; other site 401614000561 active site 401614000562 UDP-GlcNAc binding site [chemical binding]; other site 401614000563 lipid binding site [chemical binding]; lipid-binding site 401614000564 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 401614000565 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 401614000566 dimer interface [polypeptide binding]; other site 401614000567 pyridoxal binding site [chemical binding]; other site 401614000568 ATP binding site [chemical binding]; other site 401614000569 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 401614000570 MoxR-like ATPases [General function prediction only]; Region: COG0714 401614000571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614000572 Walker A motif; other site 401614000573 ATP binding site [chemical binding]; other site 401614000574 Walker B motif; other site 401614000575 arginine finger; other site 401614000576 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 401614000577 Protein of unknown function DUF58; Region: DUF58; pfam01882 401614000578 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 401614000579 hypothetical protein; Provisional; Region: PRK13685 401614000580 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 401614000581 metal ion-dependent adhesion site (MIDAS); other site 401614000582 hypothetical protein; Provisional; Region: PRK13685 401614000583 von Willebrand factor type A domain; Region: VWA_2; pfam13519 401614000584 metal ion-dependent adhesion site (MIDAS); other site 401614000585 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 401614000586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 401614000587 TPR motif; other site 401614000588 binding surface 401614000589 Oxygen tolerance; Region: BatD; pfam13584 401614000590 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 401614000591 putative substrate binding pocket [chemical binding]; other site 401614000592 AC domain interface; other site 401614000593 catalytic triad [active] 401614000594 AB domain interface; other site 401614000595 interchain disulfide; other site 401614000596 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 401614000597 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 401614000598 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 401614000599 active site 401614000600 HIGH motif; other site 401614000601 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 401614000602 KMSKS motif; other site 401614000603 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 401614000604 tRNA binding surface [nucleotide binding]; other site 401614000605 anticodon binding site; other site 401614000606 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 401614000607 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 401614000608 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 401614000609 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 401614000610 active site 401614000611 substrate binding site [chemical binding]; other site 401614000612 FMN binding site [chemical binding]; other site 401614000613 putative catalytic residues [active] 401614000614 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 401614000615 dimer interface [polypeptide binding]; other site 401614000616 FMN binding site [chemical binding]; other site 401614000617 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 401614000618 nudix motif; other site 401614000619 fumarate hydratase; Reviewed; Region: fumC; PRK00485 401614000620 Class II fumarases; Region: Fumarase_classII; cd01362 401614000621 active site 401614000622 tetramer interface [polypeptide binding]; other site 401614000623 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 401614000624 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 401614000625 active site 401614000626 HIGH motif; other site 401614000627 KMSKS motif; other site 401614000628 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 401614000629 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 401614000630 Amidinotransferase; Region: Amidinotransf; pfam02274 401614000631 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 401614000632 folate binding site [chemical binding]; other site 401614000633 NADP+ binding site [chemical binding]; other site 401614000634 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 401614000635 rRNA interaction site [nucleotide binding]; other site 401614000636 S8 interaction site; other site 401614000637 putative laminin-1 binding site; other site 401614000638 elongation factor Ts; Provisional; Region: tsf; PRK09377 401614000639 UBA/TS-N domain; Region: UBA; pfam00627 401614000640 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 401614000641 putative nucleotide binding site [chemical binding]; other site 401614000642 uridine monophosphate binding site [chemical binding]; other site 401614000643 homohexameric interface [polypeptide binding]; other site 401614000644 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 401614000645 hinge region; other site 401614000646 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 401614000647 active site 401614000648 dimer interface [polypeptide binding]; other site 401614000649 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 401614000650 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 401614000651 trimer interface [polypeptide binding]; other site 401614000652 active site 401614000653 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 401614000654 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 401614000655 S17 interaction site [polypeptide binding]; other site 401614000656 S8 interaction site; other site 401614000657 16S rRNA interaction site [nucleotide binding]; other site 401614000658 streptomycin interaction site [chemical binding]; other site 401614000659 23S rRNA interaction site [nucleotide binding]; other site 401614000660 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 401614000661 30S ribosomal protein S7; Validated; Region: PRK05302 401614000662 elongation factor G; Reviewed; Region: PRK00007 401614000663 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 401614000664 G1 box; other site 401614000665 putative GEF interaction site [polypeptide binding]; other site 401614000666 GTP/Mg2+ binding site [chemical binding]; other site 401614000667 Switch I region; other site 401614000668 G2 box; other site 401614000669 G3 box; other site 401614000670 Switch II region; other site 401614000671 G4 box; other site 401614000672 G5 box; other site 401614000673 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 401614000674 Elongation Factor G, domain II; Region: EFG_II; pfam14492 401614000675 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 401614000676 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 401614000677 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 401614000678 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 401614000679 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 401614000680 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 401614000681 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 401614000682 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 401614000683 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 401614000684 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 401614000685 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 401614000686 putative translocon binding site; other site 401614000687 protein-rRNA interface [nucleotide binding]; other site 401614000688 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 401614000689 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 401614000690 G-X-X-G motif; other site 401614000691 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 401614000692 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 401614000693 23S rRNA interface [nucleotide binding]; other site 401614000694 5S rRNA interface [nucleotide binding]; other site 401614000695 putative antibiotic binding site [chemical binding]; other site 401614000696 L25 interface [polypeptide binding]; other site 401614000697 L27 interface [polypeptide binding]; other site 401614000698 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 401614000699 23S rRNA interface [nucleotide binding]; other site 401614000700 putative translocon interaction site; other site 401614000701 signal recognition particle (SRP54) interaction site; other site 401614000702 L23 interface [polypeptide binding]; other site 401614000703 trigger factor interaction site; other site 401614000704 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 401614000705 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 401614000706 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 401614000707 RNA binding site [nucleotide binding]; other site 401614000708 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 401614000709 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 401614000710 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 401614000711 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 401614000712 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 401614000713 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 401614000714 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 401614000715 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 401614000716 23S rRNA interface [nucleotide binding]; other site 401614000717 L21e interface [polypeptide binding]; other site 401614000718 5S rRNA interface [nucleotide binding]; other site 401614000719 L27 interface [polypeptide binding]; other site 401614000720 L5 interface [polypeptide binding]; other site 401614000721 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 401614000722 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 401614000723 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 401614000724 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 401614000725 23S rRNA binding site [nucleotide binding]; other site 401614000726 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 401614000727 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 401614000728 SecY translocase; Region: SecY; pfam00344 401614000729 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 401614000730 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 401614000731 30S ribosomal protein S11; Validated; Region: PRK05309 401614000732 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 401614000733 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 401614000734 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 401614000735 RNA binding surface [nucleotide binding]; other site 401614000736 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 401614000737 alphaNTD homodimer interface [polypeptide binding]; other site 401614000738 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 401614000739 alphaNTD - beta interaction site [polypeptide binding]; other site 401614000740 alphaNTD - beta' interaction site [polypeptide binding]; other site 401614000741 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 401614000742 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 401614000743 heat shock protein 90; Provisional; Region: PRK05218 401614000744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401614000745 ATP binding site [chemical binding]; other site 401614000746 Mg2+ binding site [ion binding]; other site 401614000747 G-X-G motif; other site 401614000748 Hsp90 protein; Region: HSP90; pfam00183 401614000749 hypothetical protein; Provisional; Region: PRK11588 401614000750 CTP synthetase; Validated; Region: pyrG; PRK05380 401614000751 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 401614000752 Catalytic site [active] 401614000753 active site 401614000754 UTP binding site [chemical binding]; other site 401614000755 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 401614000756 active site 401614000757 putative oxyanion hole; other site 401614000758 catalytic triad [active] 401614000759 Nucleoside diphosphate kinase; Region: NDK; pfam00334 401614000760 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 401614000761 active site 401614000762 multimer interface [polypeptide binding]; other site 401614000763 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 401614000764 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 401614000765 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614000766 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 401614000767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614000768 Walker A motif; other site 401614000769 ATP binding site [chemical binding]; other site 401614000770 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 401614000771 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 401614000772 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 401614000773 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 401614000774 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 401614000775 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 401614000776 ferredoxin-NADP reductase; Provisional; Region: PRK10926 401614000777 FAD binding pocket [chemical binding]; other site 401614000778 FAD binding motif [chemical binding]; other site 401614000779 phosphate binding motif [ion binding]; other site 401614000780 beta-alpha-beta structure motif; other site 401614000781 NAD binding pocket [chemical binding]; other site 401614000782 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 401614000783 SnoaL-like domain; Region: SnoaL_2; pfam12680 401614000784 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 401614000785 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u4; cd03407 401614000786 Virulence protein RhuM family; Region: Virulence_RhuM; cl19850 401614000787 Fic/DOC family; Region: Fic; pfam02661 401614000788 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 401614000789 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 401614000790 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 401614000791 Transposase IS200 like; Region: Y1_Tnp; cl00848 401614000792 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 401614000793 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 401614000794 ProQ/FINO family; Region: ProQ; smart00945 401614000795 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 401614000796 Cation transport protein; Region: TrkH; cl17365 401614000797 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 401614000798 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 401614000799 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 401614000800 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 401614000801 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 401614000802 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 401614000803 active site 401614000804 lysine transporter; Provisional; Region: PRK10836 401614000805 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 401614000806 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 401614000807 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 401614000808 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 401614000809 putative active site [active] 401614000810 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 401614000811 Na binding site [ion binding]; other site 401614000812 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 401614000813 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 401614000814 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 401614000815 DXD motif; other site 401614000816 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 401614000817 Domain of unknown function DUF21; Region: DUF21; pfam01595 401614000818 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 401614000819 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 401614000820 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 401614000821 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 401614000822 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 401614000823 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 401614000824 aromatic chitin/cellulose binding site residues [chemical binding]; other site 401614000825 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 401614000826 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 401614000827 active site 401614000828 HIGH motif; other site 401614000829 KMSKS motif; other site 401614000830 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 401614000831 tRNA binding surface [nucleotide binding]; other site 401614000832 anticodon binding site; other site 401614000833 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 401614000834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614000835 S-adenosylmethionine binding site [chemical binding]; other site 401614000836 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 401614000837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614000838 putative substrate translocation pore; other site 401614000839 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 401614000840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 401614000841 Coenzyme A binding pocket [chemical binding]; other site 401614000842 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 401614000843 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 401614000844 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 401614000845 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 401614000846 active site 401614000847 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401614000848 dimer interface [polypeptide binding]; other site 401614000849 substrate binding site [chemical binding]; other site 401614000850 catalytic residues [active] 401614000851 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 401614000852 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 401614000853 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 401614000854 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 401614000855 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 401614000856 Methyltransferase domain; Region: Methyltransf_11; pfam08241 401614000857 VacJ like lipoprotein; Region: VacJ; cl01073 401614000858 BolA-like protein; Region: BolA; cl00386 401614000859 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 401614000860 anti sigma factor interaction site; other site 401614000861 regulatory phosphorylation site [posttranslational modification]; other site 401614000862 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 401614000863 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 401614000864 mce related protein; Region: MCE; pfam02470 401614000865 Permease; Region: Permease; pfam02405 401614000866 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 401614000867 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 401614000868 Walker A/P-loop; other site 401614000869 ATP binding site [chemical binding]; other site 401614000870 Q-loop/lid; other site 401614000871 ABC transporter signature motif; other site 401614000872 Walker B; other site 401614000873 D-loop; other site 401614000874 H-loop/switch region; other site 401614000875 cell division topological specificity factor MinE; Provisional; Region: PRK13990 401614000876 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 401614000877 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 401614000878 P-loop; other site 401614000879 ADP binding residues [chemical binding]; other site 401614000880 Switch I; other site 401614000881 Switch II; other site 401614000882 septum formation inhibitor; Reviewed; Region: minC; PRK04804 401614000883 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 401614000884 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 401614000885 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 401614000886 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 401614000887 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 401614000888 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 401614000889 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 401614000890 ssDNA binding site; other site 401614000891 generic binding surface II; other site 401614000892 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614000893 ATP binding site [chemical binding]; other site 401614000894 putative Mg++ binding site [ion binding]; other site 401614000895 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614000896 nucleotide binding region [chemical binding]; other site 401614000897 ATP-binding site [chemical binding]; other site 401614000898 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 401614000899 Fumarase C-terminus; Region: Fumerase_C; pfam05683 401614000900 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 401614000901 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 401614000902 nudix motif; other site 401614000903 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 401614000904 catalytic residue [active] 401614000905 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 401614000906 Sulfate transporter family; Region: Sulfate_transp; cl19250 401614000907 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401614000908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614000909 homodimer interface [polypeptide binding]; other site 401614000910 catalytic residue [active] 401614000911 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 401614000912 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 401614000913 TrkA-C domain; Region: TrkA_C; pfam02080 401614000914 TrkA-C domain; Region: TrkA_C; pfam02080 401614000915 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 401614000916 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 401614000917 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 401614000918 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 401614000919 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 401614000920 ligand binding site [chemical binding]; other site 401614000921 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl19519 401614000922 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 401614000923 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 401614000924 Fe-S cluster binding site [ion binding]; other site 401614000925 substrate binding site [chemical binding]; other site 401614000926 catalytic site [active] 401614000927 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 401614000928 homotrimer interaction site [polypeptide binding]; other site 401614000929 active site 401614000930 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 401614000931 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 401614000932 TolQ protein; Region: tolQ; TIGR02796 401614000933 TolR protein; Region: tolR; TIGR02801 401614000934 TolA protein; Region: tolA_full; TIGR02794 401614000935 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 401614000936 TolB amino-terminal domain; Region: TolB_N; pfam04052 401614000937 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 401614000938 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 401614000939 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 401614000940 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 401614000941 ligand binding site [chemical binding]; other site 401614000942 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 401614000943 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 401614000944 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614000945 FeS/SAM binding site; other site 401614000946 TRAM domain; Region: TRAM; cl01282 401614000947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614000948 short chain dehydrogenase; Provisional; Region: PRK07060 401614000949 NAD(P) binding site [chemical binding]; other site 401614000950 active site 401614000951 TIGR03643 family protein; Region: TIGR03643 401614000952 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 401614000953 DNA photolyase; Region: DNA_photolyase; pfam00875 401614000954 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 401614000955 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 401614000956 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 401614000957 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 401614000958 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 401614000959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 401614000960 YheO-like PAS domain; Region: PAS_6; pfam08348 401614000961 HTH domain; Region: HTH_22; pfam13309 401614000962 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 401614000963 integrase; Provisional; Region: PRK09692 401614000964 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 401614000965 active site 401614000966 Int/Topo IB signature motif; other site 401614000967 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 401614000968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 401614000969 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 401614000970 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 401614000971 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 401614000972 active site 401614000973 DNA binding site [nucleotide binding] 401614000974 Int/Topo IB signature motif; other site 401614000975 Helix-turn-helix domain; Region: HTH_39; pfam14090 401614000976 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 401614000977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401614000978 non-specific DNA binding site [nucleotide binding]; other site 401614000979 salt bridge; other site 401614000980 sequence-specific DNA binding site [nucleotide binding]; other site 401614000981 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 401614000982 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 401614000983 transmembrane helices; other site 401614000984 Protein of unknown function (DUF423); Region: DUF423; cl01008 401614000985 Protein of unknown function, DUF393; Region: DUF393; pfam04134 401614000986 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 401614000987 putative active site [active] 401614000988 Chorismate lyase; Region: Chor_lyase; cl01230 401614000989 ribonuclease PH; Reviewed; Region: rph; PRK00173 401614000990 Ribonuclease PH; Region: RNase_PH_bact; cd11362 401614000991 hexamer interface [polypeptide binding]; other site 401614000992 active site 401614000993 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 401614000994 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 401614000995 heat shock protein HtpX; Provisional; Region: PRK02870 401614000996 LemA family; Region: LemA; cl00742 401614000997 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 401614000998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 401614000999 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 401614001000 dimerization interface [polypeptide binding]; other site 401614001001 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 401614001002 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 401614001003 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 401614001004 Soluble P-type ATPase [General function prediction only]; Region: COG4087 401614001005 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 401614001006 dimerization interface [polypeptide binding]; other site 401614001007 putative DNA binding site [nucleotide binding]; other site 401614001008 putative Zn2+ binding site [ion binding]; other site 401614001009 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 401614001010 putative active site [active] 401614001011 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 401614001012 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 401614001013 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 401614001014 Colicin V production protein; Region: Colicin_V; pfam02674 401614001015 DNA repair protein RadA; Provisional; Region: PRK11823 401614001016 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 401614001017 Walker A motif/ATP binding site; other site 401614001018 ATP binding site [chemical binding]; other site 401614001019 Walker B motif; other site 401614001020 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 401614001021 PilZ domain; Region: PilZ; pfam07238 401614001022 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 401614001023 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 401614001024 Tetramer interface [polypeptide binding]; other site 401614001025 active site 401614001026 FMN-binding site [chemical binding]; other site 401614001027 PQ loop repeat; Region: PQ-loop; pfam04193 401614001028 methionine sulfoxide reductase B; Provisional; Region: PRK00222 401614001029 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 401614001030 E-class dimer interface [polypeptide binding]; other site 401614001031 P-class dimer interface [polypeptide binding]; other site 401614001032 active site 401614001033 Cu2+ binding site [ion binding]; other site 401614001034 Zn2+ binding site [ion binding]; other site 401614001035 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 401614001036 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 401614001037 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 401614001038 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 401614001039 Cupin domain; Region: Cupin_2; cl17218 401614001040 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 401614001041 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 401614001042 substrate binding site [chemical binding]; other site 401614001043 catalytic Zn binding site [ion binding]; other site 401614001044 NAD binding site [chemical binding]; other site 401614001045 structural Zn binding site [ion binding]; other site 401614001046 dimer interface [polypeptide binding]; other site 401614001047 aspartate aminotransferase; Provisional; Region: PRK07568 401614001048 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401614001049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614001050 homodimer interface [polypeptide binding]; other site 401614001051 catalytic residue [active] 401614001052 Cation efflux family; Region: Cation_efflux; pfam01545 401614001053 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 401614001054 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 401614001055 Walker A/P-loop; other site 401614001056 ATP binding site [chemical binding]; other site 401614001057 Q-loop/lid; other site 401614001058 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 401614001059 ABC transporter signature motif; other site 401614001060 Walker B; other site 401614001061 D-loop; other site 401614001062 H-loop/switch region; other site 401614001063 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 401614001064 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 401614001065 Pilin (bacterial filament); Region: Pilin; pfam00114 401614001066 Proteins of 100 residues with WXG; Region: WXG100; cl02005 401614001067 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 401614001068 Pilin (bacterial filament); Region: Pilin; pfam00114 401614001069 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 401614001070 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 401614001071 active site 401614001072 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 401614001073 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 401614001074 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 401614001075 homodimer interface [polypeptide binding]; other site 401614001076 NADP binding site [chemical binding]; other site 401614001077 substrate binding site [chemical binding]; other site 401614001078 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 401614001079 GIY-YIG motif/motif A; other site 401614001080 putative active site [active] 401614001081 putative metal binding site [ion binding]; other site 401614001082 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 401614001083 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 401614001084 dimerization interface [polypeptide binding]; other site 401614001085 putative ATP binding site [chemical binding]; other site 401614001086 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 401614001087 active site 401614001088 ATP binding site [chemical binding]; other site 401614001089 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 401614001090 substrate binding site [chemical binding]; other site 401614001091 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 401614001092 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 401614001093 ATP-grasp domain; Region: ATP-grasp_4; cl17255 401614001094 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 401614001095 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 401614001096 active site 401614001097 substrate binding site [chemical binding]; other site 401614001098 cosubstrate binding site; other site 401614001099 catalytic site [active] 401614001100 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 401614001101 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 401614001102 ATP-grasp domain; Region: ATP-grasp_4; cl17255 401614001103 hypothetical protein; Provisional; Region: PRK14682 401614001104 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 401614001105 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 401614001106 active site 401614001107 Zn binding site [ion binding]; other site 401614001108 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 401614001109 hypothetical protein; Provisional; Region: PRK11281 401614001110 ribonuclease Y; Region: RNase_Y; TIGR03319 401614001111 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 401614001112 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 401614001113 O-Antigen ligase; Region: Wzy_C; pfam04932 401614001114 DNA topoisomerase I; Validated; Region: PRK06599 401614001115 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 401614001116 active site 401614001117 interdomain interaction site; other site 401614001118 putative metal-binding site [ion binding]; other site 401614001119 nucleotide binding site [chemical binding]; other site 401614001120 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 401614001121 domain I; other site 401614001122 DNA binding groove [nucleotide binding] 401614001123 phosphate binding site [ion binding]; other site 401614001124 domain II; other site 401614001125 domain III; other site 401614001126 nucleotide binding site [chemical binding]; other site 401614001127 catalytic site [active] 401614001128 domain IV; other site 401614001129 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 401614001130 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 401614001131 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 401614001132 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 401614001133 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 401614001134 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 401614001135 P-loop; other site 401614001136 Magnesium ion binding site [ion binding]; other site 401614001137 ParB-like nuclease domain; Region: ParB; smart00470 401614001138 KorB domain; Region: KorB; pfam08535 401614001139 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 401614001140 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 401614001141 catalytic triad [active] 401614001142 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 401614001143 active site 401614001144 catalytic triad [active] 401614001145 oxyanion hole [active] 401614001146 HD domain; Region: HD_3; pfam13023 401614001147 FtsJ-like methyltransferase; Region: FtsJ; cl17430 401614001148 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 401614001149 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 401614001150 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 401614001151 active site 401614001152 HIGH motif; other site 401614001153 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 401614001154 KMSKS motif; other site 401614001155 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 401614001156 tRNA binding surface [nucleotide binding]; other site 401614001157 anticodon binding site; other site 401614001158 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 401614001159 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 401614001160 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 401614001161 active site 401614001162 Riboflavin kinase; Region: Flavokinase; pfam01687 401614001163 malate dehydrogenase; Provisional; Region: PRK13529 401614001164 Malic enzyme, N-terminal domain; Region: malic; pfam00390 401614001165 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 401614001166 NAD(P) binding pocket [chemical binding]; other site 401614001167 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 401614001168 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 401614001169 GTP-binding protein Der; Reviewed; Region: PRK00093 401614001170 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 401614001171 G1 box; other site 401614001172 GTP/Mg2+ binding site [chemical binding]; other site 401614001173 Switch I region; other site 401614001174 G2 box; other site 401614001175 Switch II region; other site 401614001176 G3 box; other site 401614001177 G4 box; other site 401614001178 G5 box; other site 401614001179 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 401614001180 G1 box; other site 401614001181 GTP/Mg2+ binding site [chemical binding]; other site 401614001182 Switch I region; other site 401614001183 G2 box; other site 401614001184 G3 box; other site 401614001185 Switch II region; other site 401614001186 G4 box; other site 401614001187 G5 box; other site 401614001188 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 401614001189 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 401614001190 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 401614001191 putative active site [active] 401614001192 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 401614001193 FAD binding domain; Region: FAD_binding_4; cl19922 401614001194 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 401614001195 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 401614001196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614001197 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 401614001198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 401614001199 PAS fold; Region: PAS_3; pfam08447 401614001200 putative active site [active] 401614001201 heme pocket [chemical binding]; other site 401614001202 PAS fold; Region: PAS_4; pfam08448 401614001203 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 401614001204 metal binding site [ion binding]; metal-binding site 401614001205 active site 401614001206 I-site; other site 401614001207 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 401614001208 Domain of unknown function (DUF814); Region: DUF814; pfam05670 401614001209 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 401614001210 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 401614001211 DXD motif; other site 401614001212 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 401614001213 HlyD family secretion protein; Region: HlyD_3; pfam13437 401614001214 CheB methylesterase; Region: CheB_methylest; pfam01339 401614001215 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 401614001216 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 401614001217 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 401614001218 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 401614001219 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 401614001220 PAS domain; Region: PAS_10; pfam13596 401614001221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 401614001222 PAS domain; Region: PAS_9; pfam13426 401614001223 putative active site [active] 401614001224 heme pocket [chemical binding]; other site 401614001225 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 401614001226 metal binding site [ion binding]; metal-binding site 401614001227 active site 401614001228 I-site; other site 401614001229 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 401614001230 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 401614001231 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401614001232 active site 401614001233 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 401614001234 nucleotide binding site/active site [active] 401614001235 HIT family signature motif; other site 401614001236 catalytic residue [active] 401614001237 ABC1 family; Region: ABC1; cl17513 401614001238 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 401614001239 SCP-2 sterol transfer family; Region: SCP2; cl01225 401614001240 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 401614001241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614001242 S-adenosylmethionine binding site [chemical binding]; other site 401614001243 Glucokinase; Region: Glucokinase; pfam02685 401614001244 intracellular septation protein A; Reviewed; Region: PRK00259 401614001245 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 401614001246 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 401614001247 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 401614001248 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 401614001249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001250 D-galactonate transporter; Region: 2A0114; TIGR00893 401614001251 putative substrate translocation pore; other site 401614001252 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 401614001253 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 401614001254 active site 401614001255 HIGH motif; other site 401614001256 KMSKS motif; other site 401614001257 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 401614001258 tRNA binding surface [nucleotide binding]; other site 401614001259 anticodon binding site; other site 401614001260 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 401614001261 dimer interface [polypeptide binding]; other site 401614001262 putative tRNA-binding site [nucleotide binding]; other site 401614001263 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 401614001264 Mif2/CENP-C like; Region: CENP-C_C; pfam11699 401614001265 Cupin domain; Region: Cupin_2; cl17218 401614001266 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 401614001267 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 401614001268 Peptidase family M50; Region: Peptidase_M50; pfam02163 401614001269 active site 401614001270 putative substrate binding region [chemical binding]; other site 401614001271 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 401614001272 DNA binding residues [nucleotide binding] 401614001273 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 401614001274 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 401614001275 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 401614001276 active site 401614001277 (T/H)XGH motif; other site 401614001278 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 401614001279 nudix motif; other site 401614001280 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 401614001281 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 401614001282 Substrate binding site; other site 401614001283 Mg++ binding site; other site 401614001284 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 401614001285 active site 401614001286 substrate binding site [chemical binding]; other site 401614001287 CoA binding site [chemical binding]; other site 401614001288 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 401614001289 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 401614001290 glutaminase active site [active] 401614001291 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 401614001292 dimer interface [polypeptide binding]; other site 401614001293 active site 401614001294 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 401614001295 dimer interface [polypeptide binding]; other site 401614001296 active site 401614001297 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 401614001298 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 401614001299 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 401614001300 DNA-binding site [nucleotide binding]; DNA binding site 401614001301 RNA-binding motif; other site 401614001302 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 401614001303 metal binding site [ion binding]; metal-binding site 401614001304 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 401614001305 active site 401614001306 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 401614001307 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 401614001308 CAP-like domain; other site 401614001309 active site 401614001310 primary dimer interface [polypeptide binding]; other site 401614001311 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 401614001312 BNR repeat-like domain; Region: BNR_2; pfam13088 401614001313 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 401614001314 Asp-box motif; other site 401614001315 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 401614001316 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 401614001317 N-acetyl-D-glucosamine binding site [chemical binding]; other site 401614001318 catalytic residue [active] 401614001319 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 401614001320 Predicted membrane protein [Function unknown]; Region: COG4325 401614001321 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 401614001322 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 401614001323 active site 401614001324 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 401614001325 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 401614001326 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 401614001327 generic binding surface II; other site 401614001328 generic binding surface I; other site 401614001329 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 401614001330 active site 401614001331 catalytic residues [active] 401614001332 metal binding site [ion binding]; metal-binding site 401614001333 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 401614001334 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401614001335 FtsX-like permease family; Region: FtsX; pfam02687 401614001336 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 401614001337 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 401614001338 Walker A/P-loop; other site 401614001339 ATP binding site [chemical binding]; other site 401614001340 Q-loop/lid; other site 401614001341 ABC transporter signature motif; other site 401614001342 Walker B; other site 401614001343 D-loop; other site 401614001344 H-loop/switch region; other site 401614001345 lysine decarboxylase LdcC; Provisional; Region: PRK15399 401614001346 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 401614001347 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 401614001348 homodimer interface [polypeptide binding]; other site 401614001349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614001350 catalytic residue [active] 401614001351 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 401614001352 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 401614001353 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 401614001354 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 401614001355 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 401614001356 lipoyl attachment site [posttranslational modification]; other site 401614001357 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 401614001358 tetramer interface [polypeptide binding]; other site 401614001359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614001360 catalytic residue [active] 401614001361 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 401614001362 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614001363 catalytic residue [active] 401614001364 Predicted helicase [General function prediction only]; Region: COG4889 401614001365 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 401614001366 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 401614001367 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 401614001368 NAD(P) binding pocket [chemical binding]; other site 401614001369 pullulanase, type I; Region: pulA_typeI; TIGR02104 401614001370 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 401614001371 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 401614001372 Ca binding site [ion binding]; other site 401614001373 active site 401614001374 catalytic site [active] 401614001375 glycogen branching enzyme; Provisional; Region: PRK12313 401614001376 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 401614001377 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 401614001378 active site 401614001379 catalytic site [active] 401614001380 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 401614001381 phosphoglucomutase; Region: PLN02307 401614001382 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 401614001383 substrate binding site [chemical binding]; other site 401614001384 dimer interface [polypeptide binding]; other site 401614001385 active site 401614001386 metal binding site [ion binding]; metal-binding site 401614001387 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 401614001388 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 401614001389 ligand binding site; other site 401614001390 oligomer interface; other site 401614001391 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 401614001392 dimer interface [polypeptide binding]; other site 401614001393 N-terminal domain interface [polypeptide binding]; other site 401614001394 sulfate 1 binding site; other site 401614001395 glycogen synthase; Provisional; Region: glgA; PRK00654 401614001396 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 401614001397 ADP-binding pocket [chemical binding]; other site 401614001398 homodimer interface [polypeptide binding]; other site 401614001399 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 401614001400 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 401614001401 4-alpha-glucanotransferase; Provisional; Region: PRK14508 401614001402 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 401614001403 dimer interface [polypeptide binding]; other site 401614001404 motif 1; other site 401614001405 active site 401614001406 motif 2; other site 401614001407 motif 3; other site 401614001408 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 401614001409 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 401614001410 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614001411 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401614001412 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 401614001413 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 401614001414 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 401614001415 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614001416 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401614001417 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 401614001418 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 401614001419 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 401614001420 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 401614001421 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 401614001422 nucleotide binding site [chemical binding]; other site 401614001423 substrate binding site [chemical binding]; other site 401614001424 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 401614001425 dimer interface [polypeptide binding]; other site 401614001426 putative threonine allosteric regulatory site; other site 401614001427 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 401614001428 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 401614001429 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 401614001430 homoserine kinase; Provisional; Region: PRK01212 401614001431 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 401614001432 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 401614001433 threonine synthase; Validated; Region: PRK09225 401614001434 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 401614001435 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614001436 catalytic residue [active] 401614001437 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 401614001438 putative active site [active] 401614001439 putative metal binding site [ion binding]; other site 401614001440 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401614001441 active site 401614001442 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 401614001443 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 401614001444 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614001445 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401614001446 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 401614001447 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 401614001448 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 401614001449 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 401614001450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614001452 putative substrate translocation pore; other site 401614001453 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 401614001454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614001455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001456 putative substrate translocation pore; other site 401614001457 ABC transporter ATPase component; Reviewed; Region: PRK11147 401614001458 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 401614001459 ABC transporter; Region: ABC_tran_2; pfam12848 401614001460 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 401614001461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001462 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 401614001463 putative substrate translocation pore; other site 401614001464 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 401614001465 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 401614001466 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 401614001467 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 401614001468 active site 401614001469 HIGH motif; other site 401614001470 KMSKS motif; other site 401614001471 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 401614001472 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 401614001473 active site 401614001474 metal-binding site [ion binding] 401614001475 nucleotide-binding site [chemical binding]; other site 401614001476 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 401614001477 Mg++ binding site [ion binding]; other site 401614001478 putative catalytic motif [active] 401614001479 putative substrate binding site [chemical binding]; other site 401614001480 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 401614001481 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614001482 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401614001483 cell division protein FtsW; Region: ftsW; TIGR02614 401614001484 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 401614001485 putative active site [active] 401614001486 YdjC motif; other site 401614001487 Mg binding site [ion binding]; other site 401614001488 putative homodimer interface [polypeptide binding]; other site 401614001489 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 401614001490 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 401614001491 Ligand binding site; other site 401614001492 Putative Catalytic site; other site 401614001493 DXD motif; other site 401614001494 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 401614001495 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 401614001496 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 401614001497 oxidative damage protection protein; Provisional; Region: PRK05408 401614001498 DsrC like protein; Region: DsrC; pfam04358 401614001499 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 401614001500 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 401614001501 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 401614001502 N-terminal domain interface [polypeptide binding]; other site 401614001503 dimer interface [polypeptide binding]; other site 401614001504 substrate binding pocket (H-site) [chemical binding]; other site 401614001505 putative inner membrane peptidase; Provisional; Region: PRK11778 401614001506 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 401614001507 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 401614001508 tandem repeat interface [polypeptide binding]; other site 401614001509 oligomer interface [polypeptide binding]; other site 401614001510 active site residues [active] 401614001511 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 401614001512 DNA polymerase III subunit delta'; Validated; Region: PRK08485 401614001513 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 401614001514 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 401614001515 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 401614001516 dimer interface [polypeptide binding]; other site 401614001517 active site 401614001518 Schiff base residues; other site 401614001519 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 401614001520 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 401614001521 active site 401614001522 homotetramer interface [polypeptide binding]; other site 401614001523 homodimer interface [polypeptide binding]; other site 401614001524 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 401614001525 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 401614001526 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 401614001527 active site 401614001528 HIGH motif; other site 401614001529 KMSK motif region; other site 401614001530 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 401614001531 tRNA binding surface [nucleotide binding]; other site 401614001532 anticodon binding site; other site 401614001533 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 401614001534 OstA-like protein; Region: OstA; cl00844 401614001535 Organic solvent tolerance protein; Region: OstA_C; pfam04453 401614001536 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 401614001537 SurA N-terminal domain; Region: SurA_N; pfam09312 401614001538 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 401614001539 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 401614001540 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 401614001541 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 401614001542 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 401614001543 active site 401614001544 metal binding site [ion binding]; metal-binding site 401614001545 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 401614001546 trimer interface [polypeptide binding]; other site 401614001547 active site 401614001548 dimer interface [polypeptide binding]; other site 401614001549 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 401614001550 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 401614001551 carboxyltransferase (CT) interaction site; other site 401614001552 biotinylation site [posttranslational modification]; other site 401614001553 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 401614001554 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 401614001555 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 401614001556 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 401614001557 Helix-turn-helix domain; Region: HTH_25; pfam13413 401614001558 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 401614001559 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 401614001560 Mechanosensitive ion channel; Region: MS_channel; pfam00924 401614001561 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 401614001562 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 401614001563 motif 1; other site 401614001564 dimer interface [polypeptide binding]; other site 401614001565 active site 401614001566 motif 2; other site 401614001567 motif 3; other site 401614001568 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 401614001569 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 401614001570 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 401614001571 DHH family; Region: DHH; pfam01368 401614001572 DHHA1 domain; Region: DHHA1; pfam02272 401614001573 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 401614001574 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 401614001575 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 401614001576 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 401614001577 Predicted GTPases [General function prediction only]; Region: COG1162 401614001578 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 401614001579 GTPase/Zn-binding domain interface [polypeptide binding]; other site 401614001580 GTP/Mg2+ binding site [chemical binding]; other site 401614001581 G4 box; other site 401614001582 G5 box; other site 401614001583 G1 box; other site 401614001584 Switch I region; other site 401614001585 G2 box; other site 401614001586 G3 box; other site 401614001587 Switch II region; other site 401614001588 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 401614001589 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 401614001590 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 401614001591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401614001592 ATP binding site [chemical binding]; other site 401614001593 Mg2+ binding site [ion binding]; other site 401614001594 G-X-G motif; other site 401614001595 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 401614001596 ATP binding site [chemical binding]; other site 401614001597 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 401614001598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001599 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614001600 putative substrate translocation pore; other site 401614001601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001602 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614001603 putative substrate translocation pore; other site 401614001604 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 401614001605 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 401614001606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401614001607 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 401614001608 PLD-like domain; Region: PLDc_2; pfam13091 401614001609 putative active site [active] 401614001610 catalytic site [active] 401614001611 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 401614001612 PLD-like domain; Region: PLDc_2; pfam13091 401614001613 putative active site [active] 401614001614 putative catalytic site [active] 401614001615 phosphoglycolate phosphatase; Provisional; Region: PRK13222 401614001616 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 401614001617 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401614001618 motif II; other site 401614001619 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614001620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 401614001621 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 401614001622 putative effector binding pocket; other site 401614001623 dimerization interface [polypeptide binding]; other site 401614001624 MFS transport protein AraJ; Provisional; Region: PRK10091 401614001625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001626 putative substrate translocation pore; other site 401614001627 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 401614001628 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 401614001629 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 401614001630 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 401614001631 Zn2+ binding site [ion binding]; other site 401614001632 Mg2+ binding site [ion binding]; other site 401614001633 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 401614001634 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 401614001635 active site 401614001636 dimer interface [polypeptide binding]; other site 401614001637 catalytic nucleophile [active] 401614001638 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 401614001639 POT family; Region: PTR2; cl17359 401614001640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001641 putative substrate translocation pore; other site 401614001642 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 401614001643 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 401614001644 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 401614001645 CoA binding domain; Region: CoA_binding; smart00881 401614001646 CoA-ligase; Region: Ligase_CoA; pfam00549 401614001647 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 401614001648 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 401614001649 CoA-ligase; Region: Ligase_CoA; pfam00549 401614001650 TIGR03546 family protein; Region: TIGR03546 401614001651 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 401614001652 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 401614001653 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 401614001654 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 401614001655 FMN binding site [chemical binding]; other site 401614001656 active site 401614001657 catalytic residues [active] 401614001658 substrate binding site [chemical binding]; other site 401614001659 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 401614001660 putative active site pocket [active] 401614001661 dimerization interface [polypeptide binding]; other site 401614001662 putative catalytic residue [active] 401614001663 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 401614001664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401614001665 ATP binding site [chemical binding]; other site 401614001666 Mg2+ binding site [ion binding]; other site 401614001667 G-X-G motif; other site 401614001668 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 401614001669 anchoring element; other site 401614001670 dimer interface [polypeptide binding]; other site 401614001671 ATP binding site [chemical binding]; other site 401614001672 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 401614001673 active site 401614001674 putative metal-binding site [ion binding]; other site 401614001675 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 401614001676 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 401614001677 active site 401614001678 multimer interface [polypeptide binding]; other site 401614001679 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 401614001680 predicted active site [active] 401614001681 catalytic triad [active] 401614001682 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 401614001683 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 401614001684 DNA binding site [nucleotide binding] 401614001685 catalytic residue [active] 401614001686 H2TH interface [polypeptide binding]; other site 401614001687 putative catalytic residues [active] 401614001688 turnover-facilitating residue; other site 401614001689 intercalation triad [nucleotide binding]; other site 401614001690 8OG recognition residue [nucleotide binding]; other site 401614001691 putative reading head residues; other site 401614001692 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 401614001693 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 401614001694 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 401614001695 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 401614001696 acyl-activating enzyme (AAE) consensus motif; other site 401614001697 putative AMP binding site [chemical binding]; other site 401614001698 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 401614001699 Cell division protein FtsL; Region: FtsL; cl11433 401614001700 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 401614001701 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 401614001702 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 401614001703 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 401614001704 16S/18S rRNA binding site [nucleotide binding]; other site 401614001705 S13e-L30e interaction site [polypeptide binding]; other site 401614001706 25S rRNA binding site [nucleotide binding]; other site 401614001707 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 401614001708 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 401614001709 oligomer interface [polypeptide binding]; other site 401614001710 RNA binding site [nucleotide binding]; other site 401614001711 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 401614001712 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 401614001713 RNase E interface [polypeptide binding]; other site 401614001714 trimer interface [polypeptide binding]; other site 401614001715 active site 401614001716 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 401614001717 putative nucleic acid binding region [nucleotide binding]; other site 401614001718 G-X-X-G motif; other site 401614001719 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 401614001720 RNA binding site [nucleotide binding]; other site 401614001721 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 401614001722 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 401614001723 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 401614001724 ATP-binding site [chemical binding]; other site 401614001725 Sugar specificity; other site 401614001726 Pyrimidine base specificity; other site 401614001727 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 401614001728 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 401614001729 TRAM domain; Region: TRAM; cl01282 401614001730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614001731 S-adenosylmethionine binding site [chemical binding]; other site 401614001732 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401614001733 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 401614001734 nucleotide binding site [chemical binding]; other site 401614001735 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401614001736 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 401614001737 nucleotide binding site [chemical binding]; other site 401614001738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001739 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614001740 putative substrate translocation pore; other site 401614001741 enolase; Provisional; Region: eno; PRK00077 401614001742 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 401614001743 dimer interface [polypeptide binding]; other site 401614001744 metal binding site [ion binding]; metal-binding site 401614001745 substrate binding pocket [chemical binding]; other site 401614001746 Septum formation initiator; Region: DivIC; cl17659 401614001747 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 401614001748 substrate binding site; other site 401614001749 dimer interface; other site 401614001750 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 401614001751 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 401614001752 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 401614001753 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 401614001754 NAD(P) binding site [chemical binding]; other site 401614001755 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 401614001756 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 401614001757 substrate-cofactor binding pocket; other site 401614001758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614001759 catalytic residue [active] 401614001760 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 401614001761 Glyco_18 domain; Region: Glyco_18; smart00636 401614001762 active site 401614001763 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 401614001764 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 401614001765 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 401614001766 aromatic chitin/cellulose binding site residues [chemical binding]; other site 401614001767 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 401614001768 aromatic chitin/cellulose binding site residues [chemical binding]; other site 401614001769 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 401614001770 aromatic chitin/cellulose binding site residues [chemical binding]; other site 401614001771 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401614001772 active site 401614001773 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 401614001774 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 401614001775 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 401614001776 active site 401614001777 substrate binding site [chemical binding]; other site 401614001778 cosubstrate binding site; other site 401614001779 catalytic site [active] 401614001780 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 401614001781 putative substrate binding pocket [chemical binding]; other site 401614001782 trimer interface [polypeptide binding]; other site 401614001783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001784 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614001785 putative substrate translocation pore; other site 401614001786 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 401614001787 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 401614001788 Zn2+ binding site [ion binding]; other site 401614001789 Mg2+ binding site [ion binding]; other site 401614001790 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 401614001791 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 401614001792 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 401614001793 dimer interface [polypeptide binding]; other site 401614001794 active site 401614001795 heme binding site [chemical binding]; other site 401614001796 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 401614001797 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 401614001798 classical (c) SDRs; Region: SDR_c; cd05233 401614001799 NAD(P) binding site [chemical binding]; other site 401614001800 active site 401614001801 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 401614001802 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 401614001803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001804 putative substrate translocation pore; other site 401614001805 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 401614001806 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 401614001807 active site 401614001808 catalytic site [active] 401614001809 metal binding site [ion binding]; metal-binding site 401614001810 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 401614001811 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 401614001812 Sulfate transporter family; Region: Sulfate_transp; pfam00916 401614001813 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 401614001814 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 401614001815 homotrimer interaction site [polypeptide binding]; other site 401614001816 putative active site [active] 401614001817 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 401614001818 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 401614001819 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 401614001820 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401614001821 Walker A/P-loop; other site 401614001822 ATP binding site [chemical binding]; other site 401614001823 Q-loop/lid; other site 401614001824 ABC transporter signature motif; other site 401614001825 Walker B; other site 401614001826 D-loop; other site 401614001827 H-loop/switch region; other site 401614001828 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 401614001829 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 401614001830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401614001831 Walker A/P-loop; other site 401614001832 ATP binding site [chemical binding]; other site 401614001833 Q-loop/lid; other site 401614001834 ABC transporter signature motif; other site 401614001835 Walker B; other site 401614001836 D-loop; other site 401614001837 H-loop/switch region; other site 401614001838 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 401614001839 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 401614001840 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401614001841 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 401614001842 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 401614001843 seryl-tRNA synthetase; Provisional; Region: PRK05431 401614001844 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 401614001845 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 401614001846 dimer interface [polypeptide binding]; other site 401614001847 active site 401614001848 motif 1; other site 401614001849 motif 2; other site 401614001850 motif 3; other site 401614001851 phosphoglyceromutase; Provisional; Region: PRK05434 401614001852 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 401614001853 FAD binding domain; Region: FAD_binding_4; pfam01565 401614001854 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 401614001855 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 401614001856 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 401614001857 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 401614001858 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 401614001859 active site 401614001860 catalytic motif [active] 401614001861 Zn binding site [ion binding]; other site 401614001862 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 401614001863 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 401614001864 active site 401614001865 dinuclear metal binding site [ion binding]; other site 401614001866 dimerization interface [polypeptide binding]; other site 401614001867 Predicted membrane protein [Function unknown]; Region: COG2860 401614001868 UPF0126 domain; Region: UPF0126; pfam03458 401614001869 UPF0126 domain; Region: UPF0126; pfam03458 401614001870 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 401614001871 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 401614001872 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 401614001873 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 401614001874 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 401614001875 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 401614001876 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 401614001877 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 401614001878 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 401614001879 multifunctional aminopeptidase A; Provisional; Region: PRK00913 401614001880 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 401614001881 interface (dimer of trimers) [polypeptide binding]; other site 401614001882 Substrate-binding/catalytic site; other site 401614001883 Zn-binding sites [ion binding]; other site 401614001884 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 401614001885 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 401614001886 active site 401614001887 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 401614001888 Thiamine pyrophosphokinase; Region: TPK; cd07995 401614001889 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 401614001890 active site 401614001891 dimerization interface [polypeptide binding]; other site 401614001892 thiamine binding site [chemical binding]; other site 401614001893 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 401614001894 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 401614001895 active site 401614001896 dimer interface [polypeptide binding]; other site 401614001897 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 401614001898 dimer interface [polypeptide binding]; other site 401614001899 active site 401614001900 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 401614001901 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 401614001902 Type II transport protein GspH; Region: GspH; pfam12019 401614001903 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 401614001904 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 401614001905 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 401614001906 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 401614001907 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 401614001908 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 401614001909 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 401614001910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001911 putative transporter; Provisional; Region: PRK10504 401614001912 putative substrate translocation pore; other site 401614001913 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 401614001914 FtsH Extracellular; Region: FtsH_ext; pfam06480 401614001915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614001916 Walker A motif; other site 401614001917 ATP binding site [chemical binding]; other site 401614001918 Walker B motif; other site 401614001919 arginine finger; other site 401614001920 Peptidase family M41; Region: Peptidase_M41; pfam01434 401614001921 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 401614001922 LPP20 lipoprotein; Region: LPP20; pfam02169 401614001923 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 401614001924 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614001925 ATP binding site [chemical binding]; other site 401614001926 putative Mg++ binding site [ion binding]; other site 401614001927 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 401614001928 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 401614001929 SEC-C motif; Region: SEC-C; pfam02810 401614001930 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 401614001931 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 401614001932 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 401614001933 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 401614001934 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 401614001935 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 401614001936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001937 putative substrate translocation pore; other site 401614001938 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 401614001939 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 401614001940 catalytic site [active] 401614001941 putative active site [active] 401614001942 putative substrate binding site [chemical binding]; other site 401614001943 HRDC domain; Region: HRDC; pfam00570 401614001944 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 401614001945 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 401614001946 GIY-YIG motif/motif A; other site 401614001947 active site 401614001948 catalytic site [active] 401614001949 putative DNA binding site [nucleotide binding]; other site 401614001950 metal binding site [ion binding]; metal-binding site 401614001951 UvrB/uvrC motif; Region: UVR; pfam02151 401614001952 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 401614001953 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 401614001954 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 401614001955 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 401614001956 active site 401614001957 Uncharacterized conserved protein [Function unknown]; Region: COG2835 401614001958 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 401614001959 Ligand binding site; other site 401614001960 oligomer interface; other site 401614001961 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 401614001962 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 401614001963 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 401614001964 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 401614001965 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 401614001966 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 401614001967 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 401614001968 dimer interface [polypeptide binding]; other site 401614001969 active site 401614001970 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 401614001971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001972 putative substrate translocation pore; other site 401614001973 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 401614001974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614001975 putative substrate translocation pore; other site 401614001976 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 401614001977 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 401614001978 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 401614001979 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 401614001980 ATP binding site [chemical binding]; other site 401614001981 Mg++ binding site [ion binding]; other site 401614001982 motif III; other site 401614001983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614001984 nucleotide binding region [chemical binding]; other site 401614001985 ATP-binding site [chemical binding]; other site 401614001986 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 401614001987 putative RNA binding site [nucleotide binding]; other site 401614001988 Guanylate kinase; Region: Guanylate_kin; pfam00625 401614001989 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 401614001990 catalytic site [active] 401614001991 G-X2-G-X-G-K; other site 401614001992 quinolinate synthetase; Provisional; Region: PRK09375 401614001993 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 401614001994 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 401614001995 dimerization interface [polypeptide binding]; other site 401614001996 active site 401614001997 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 401614001998 L-aspartate oxidase; Provisional; Region: PRK06175 401614001999 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 401614002000 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 401614002001 active site 401614002002 Chorismate mutase type II; Region: CM_2; smart00830 401614002003 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 401614002004 catalytic residues [active] 401614002005 dimer interface [polypeptide binding]; other site 401614002006 Protein of unknown function (DUF819); Region: DUF819; cl02317 401614002007 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 401614002008 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 401614002009 active site 401614002010 Putative serine esterase (DUF676); Region: DUF676; pfam05057 401614002011 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 401614002012 Putative lysophospholipase; Region: Hydrolase_4; cl19140 401614002013 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 401614002014 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 401614002015 putative substrate binding site [chemical binding]; other site 401614002016 putative ATP binding site [chemical binding]; other site 401614002017 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 401614002018 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 401614002019 HsdM N-terminal domain; Region: HsdM_N; pfam12161 401614002020 Methyltransferase domain; Region: Methyltransf_26; pfam13659 401614002021 Abi-like protein; Region: Abi_2; pfam07751 401614002022 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 401614002023 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 401614002024 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 401614002025 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 401614002026 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 401614002027 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 401614002028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614002029 ATP binding site [chemical binding]; other site 401614002030 putative Mg++ binding site [ion binding]; other site 401614002031 Protein of unknown function DUF45; Region: DUF45; pfam01863 401614002032 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 401614002033 RNA binding surface [nucleotide binding]; other site 401614002034 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 401614002035 OstA-like protein; Region: OstA; cl00844 401614002036 Organic solvent tolerance protein; Region: OstA_C; pfam04453 401614002037 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 401614002038 Fusaric acid resistance protein family; Region: FUSC; pfam04632 401614002039 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 401614002040 multidrug resistance protein MdtN; Provisional; Region: PRK10476 401614002041 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 401614002042 HlyD family secretion protein; Region: HlyD_3; pfam13437 401614002043 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 401614002044 Transcriptional regulator [Transcription]; Region: IclR; COG1414 401614002045 Bacterial transcriptional regulator; Region: IclR; pfam01614 401614002046 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 401614002047 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 401614002048 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 401614002049 KamA family protein; Region: TIGR00238; cl15377 401614002050 Radical SAM superfamily; Region: Radical_SAM; pfam04055 401614002051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614002052 FeS/SAM binding site; other site 401614002053 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 401614002054 DNA-binding site [nucleotide binding]; DNA binding site 401614002055 RNA-binding motif; other site 401614002056 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 401614002057 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 401614002058 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 401614002059 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 401614002060 active site 401614002061 tetramer interface; other site 401614002062 acetyl-CoA synthetase; Provisional; Region: PRK00174 401614002063 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 401614002064 active site 401614002065 CoA binding site [chemical binding]; other site 401614002066 acyl-activating enzyme (AAE) consensus motif; other site 401614002067 AMP binding site [chemical binding]; other site 401614002068 acetate binding site [chemical binding]; other site 401614002069 EamA-like transporter family; Region: EamA; pfam00892 401614002070 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 401614002071 EamA-like transporter family; Region: EamA; pfam00892 401614002072 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 401614002073 recombination protein F; Reviewed; Region: recF; PRK00064 401614002074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401614002075 Walker A/P-loop; other site 401614002076 ATP binding site [chemical binding]; other site 401614002077 Q-loop/lid; other site 401614002078 ABC transporter signature motif; other site 401614002079 Walker B; other site 401614002080 D-loop; other site 401614002081 H-loop/switch region; other site 401614002082 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 401614002083 active site 401614002084 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 401614002085 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 401614002086 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 401614002087 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 401614002088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614002089 dimer interface [polypeptide binding]; other site 401614002090 conserved gate region; other site 401614002091 putative PBP binding loops; other site 401614002092 ABC-ATPase subunit interface; other site 401614002093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614002094 dimer interface [polypeptide binding]; other site 401614002095 conserved gate region; other site 401614002096 putative PBP binding loops; other site 401614002097 ABC-ATPase subunit interface; other site 401614002098 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 401614002099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401614002100 Walker A/P-loop; other site 401614002101 ATP binding site [chemical binding]; other site 401614002102 Q-loop/lid; other site 401614002103 ABC transporter signature motif; other site 401614002104 Walker B; other site 401614002105 D-loop; other site 401614002106 H-loop/switch region; other site 401614002107 TOBE domain; Region: TOBE_2; pfam08402 401614002108 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 401614002109 POT family; Region: PTR2; cl17359 401614002110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002111 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 401614002112 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 401614002113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401614002114 motif II; other site 401614002115 hypothetical protein; Provisional; Region: PRK14013 401614002116 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 401614002117 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 401614002118 putative C-terminal domain interface [polypeptide binding]; other site 401614002119 putative GSH binding site [chemical binding]; other site 401614002120 putative dimer interface [polypeptide binding]; other site 401614002121 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 401614002122 putative N-terminal domain interface [polypeptide binding]; other site 401614002123 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 401614002124 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 401614002125 active site 401614002126 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401614002127 dimer interface [polypeptide binding]; other site 401614002128 substrate binding site [chemical binding]; other site 401614002129 catalytic residues [active] 401614002130 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 401614002131 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 401614002132 Prephenate dehydratase; Region: PDT; pfam00800 401614002133 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 401614002134 putative L-Phe binding site [chemical binding]; other site 401614002135 Protein of unknown function DUF45; Region: DUF45; pfam01863 401614002136 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 401614002137 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 401614002138 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 401614002139 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 401614002140 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614002141 catalytic residue [active] 401614002142 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 401614002143 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 401614002144 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 401614002145 active site 401614002146 (T/H)XGH motif; other site 401614002147 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 401614002148 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 401614002149 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 401614002150 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 401614002151 ligand binding site [chemical binding]; other site 401614002152 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 401614002153 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 401614002154 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 401614002155 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 401614002156 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 401614002157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614002158 FeS/SAM binding site; other site 401614002159 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 401614002160 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 401614002161 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 401614002162 active site 401614002163 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 401614002164 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 401614002165 active site 401614002166 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 401614002167 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 401614002168 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 401614002169 BCCT family transporter; Region: BCCT; pfam02028 401614002170 TspO/MBR family; Region: TspO_MBR; pfam03073 401614002171 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 401614002172 SelR domain; Region: SelR; cl15841 401614002173 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 401614002174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614002175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002176 putative substrate translocation pore; other site 401614002177 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 401614002178 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 401614002179 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 401614002180 catalytic residues [active] 401614002181 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 401614002182 epoxyqueuosine reductase; Region: TIGR00276 401614002183 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 401614002184 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 401614002185 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 401614002186 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 401614002187 Part of AAA domain; Region: AAA_19; pfam13245 401614002188 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 401614002189 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 401614002190 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 401614002191 motif 1; other site 401614002192 active site 401614002193 motif 2; other site 401614002194 motif 3; other site 401614002195 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 401614002196 DHHA1 domain; Region: DHHA1; pfam02272 401614002197 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 401614002198 Outer membrane efflux protein; Region: OEP; pfam02321 401614002199 Outer membrane efflux protein; Region: OEP; pfam02321 401614002200 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 401614002201 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 401614002202 interface (dimer of trimers) [polypeptide binding]; other site 401614002203 Substrate-binding/catalytic site; other site 401614002204 Zn-binding sites [ion binding]; other site 401614002205 transaldolase-like protein; Provisional; Region: PTZ00411 401614002206 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 401614002207 active site 401614002208 dimer interface [polypeptide binding]; other site 401614002209 catalytic residue [active] 401614002210 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 401614002211 catalytic triad [active] 401614002212 conserved cis-peptide bond; other site 401614002213 Isochorismatase family; Region: Isochorismatase; pfam00857 401614002214 catalytic triad [active] 401614002215 conserved cis-peptide bond; other site 401614002216 Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893 401614002217 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 401614002218 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 401614002219 Part of AAA domain; Region: AAA_19; pfam13245 401614002220 AAA domain; Region: AAA_14; pfam13173 401614002221 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 401614002222 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 401614002223 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 401614002224 S1 domain; Region: S1_2; pfam13509 401614002225 S1 domain; Region: S1_2; pfam13509 401614002226 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 401614002227 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 401614002228 active site residue [active] 401614002229 recombination associated protein; Reviewed; Region: rdgC; PRK00321 401614002230 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 401614002231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401614002232 non-specific DNA binding site [nucleotide binding]; other site 401614002233 salt bridge; other site 401614002234 sequence-specific DNA binding site [nucleotide binding]; other site 401614002235 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 401614002236 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 401614002237 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 401614002238 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 401614002239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 401614002240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614002241 S-adenosylmethionine binding site [chemical binding]; other site 401614002242 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 401614002243 arsenical-resistance protein; Region: acr3; TIGR00832 401614002244 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 401614002245 dimerization interface [polypeptide binding]; other site 401614002246 putative DNA binding site [nucleotide binding]; other site 401614002247 putative Zn2+ binding site [ion binding]; other site 401614002248 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 401614002249 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 401614002250 putative active site [active] 401614002251 substrate binding site [chemical binding]; other site 401614002252 putative cosubstrate binding site; other site 401614002253 catalytic site [active] 401614002254 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 401614002255 substrate binding site [chemical binding]; other site 401614002256 glutathione synthetase; Provisional; Region: PRK05246 401614002257 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 401614002258 ATP-grasp domain; Region: ATP-grasp_4; cl17255 401614002259 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 401614002260 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 401614002261 inhibitor-cofactor binding pocket; inhibition site 401614002262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614002263 catalytic residue [active] 401614002264 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 401614002265 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 401614002266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614002267 NAD(P) binding site [chemical binding]; other site 401614002268 active site 401614002269 acetoacetate decarboxylase; Provisional; Region: PRK02265 401614002270 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 401614002271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002272 putative substrate translocation pore; other site 401614002273 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401614002274 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 401614002275 nucleotide binding site [chemical binding]; other site 401614002276 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 401614002277 dimerization interface [polypeptide binding]; other site 401614002278 putative DNA binding site [nucleotide binding]; other site 401614002279 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 401614002280 putative Zn2+ binding site [ion binding]; other site 401614002281 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 401614002282 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 401614002283 AAA domain; Region: AAA_26; pfam13500 401614002284 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 401614002285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 401614002286 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 401614002287 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 401614002288 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614002289 catalytic residue [active] 401614002290 biotin synthase; Region: bioB; TIGR00433 401614002291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614002292 FeS/SAM binding site; other site 401614002293 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 401614002294 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 401614002295 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 401614002296 inhibitor-cofactor binding pocket; inhibition site 401614002297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614002298 catalytic residue [active] 401614002299 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 401614002300 active site 2 [active] 401614002301 active site 1 [active] 401614002302 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 401614002303 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 401614002304 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 401614002305 catalytic center binding site [active] 401614002306 ATP binding site [chemical binding]; other site 401614002307 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 401614002308 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 401614002309 substrate binding pocket [chemical binding]; other site 401614002310 dimer interface [polypeptide binding]; other site 401614002311 inhibitor binding site; inhibition site 401614002312 Dihydroneopterin aldolase; Region: FolB; smart00905 401614002313 active site 401614002314 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 401614002315 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 401614002316 acyl-activating enzyme (AAE) consensus motif; other site 401614002317 AMP binding site [chemical binding]; other site 401614002318 active site 401614002319 CoA binding site [chemical binding]; other site 401614002320 aminodeoxychorismate synthase; Provisional; Region: PRK07508 401614002321 chorismate binding enzyme; Region: Chorismate_bind; cl10555 401614002322 Aminotransferase class IV; Region: Aminotran_4; pfam01063 401614002323 substrate-cofactor binding pocket; other site 401614002324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614002325 homodimer interface [polypeptide binding]; other site 401614002326 catalytic residue [active] 401614002327 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 401614002328 Glutamine amidotransferase class-I; Region: GATase; pfam00117 401614002329 glutamine binding [chemical binding]; other site 401614002330 catalytic triad [active] 401614002331 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 401614002332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002333 putative substrate translocation pore; other site 401614002334 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 401614002335 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 401614002336 active site 401614002337 catalytic tetrad [active] 401614002338 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 401614002339 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 401614002340 active site 401614002341 catalytic tetrad [active] 401614002342 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 401614002343 active site 401614002344 catalytic triad [active] 401614002345 dimer interface [polypeptide binding]; other site 401614002346 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 401614002347 putative active site [active] 401614002348 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 401614002349 active site 401614002350 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 401614002351 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 401614002352 ATP binding site [chemical binding]; other site 401614002353 Mg++ binding site [ion binding]; other site 401614002354 motif III; other site 401614002355 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614002356 nucleotide binding region [chemical binding]; other site 401614002357 ATP-binding site [chemical binding]; other site 401614002358 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 401614002359 POT family; Region: PTR2; cl17359 401614002360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002361 putative substrate translocation pore; other site 401614002362 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 401614002363 glutathione reductase; Validated; Region: PRK06116 401614002364 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 401614002365 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401614002366 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 401614002367 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 401614002368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614002369 AAA domain; Region: AAA_17; cl19128 401614002370 AAA domain; Region: AAA_33; pfam13671 401614002371 Walker A motif; other site 401614002372 ATP binding site [chemical binding]; other site 401614002373 Walker B motif; other site 401614002374 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 401614002375 putative active site [active] 401614002376 putative catalytic site [active] 401614002377 putative DNA binding site [nucleotide binding]; other site 401614002378 putative phosphate binding site [ion binding]; other site 401614002379 metal binding site A [ion binding]; metal-binding site 401614002380 putative AP binding site [nucleotide binding]; other site 401614002381 putative metal binding site B [ion binding]; other site 401614002382 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 401614002383 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 401614002384 active site 401614002385 Zn binding site [ion binding]; other site 401614002386 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 401614002387 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 401614002388 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 401614002389 potential catalytic triad [active] 401614002390 conserved cys residue [active] 401614002391 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 401614002392 signal recognition particle protein; Provisional; Region: PRK10867 401614002393 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 401614002394 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 401614002395 P loop; other site 401614002396 GTP binding site [chemical binding]; other site 401614002397 Signal peptide binding domain; Region: SRP_SPB; pfam02978 401614002398 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 401614002399 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 401614002400 rRNA binding site [nucleotide binding]; other site 401614002401 predicted 30S ribosome binding site; other site 401614002402 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 401614002403 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 401614002404 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 401614002405 TrkA-N domain; Region: TrkA_N; pfam02254 401614002406 TrkA-N domain; Region: TrkA_N; pfam02254 401614002407 Transcriptional regulator; Region: Rrf2; cl17282 401614002408 Rrf2 family protein; Region: rrf2_super; TIGR00738 401614002409 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 401614002410 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 401614002411 FeS assembly ATPase SufC; Region: sufC; TIGR01978 401614002412 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 401614002413 Walker A/P-loop; other site 401614002414 ATP binding site [chemical binding]; other site 401614002415 Q-loop/lid; other site 401614002416 ABC transporter signature motif; other site 401614002417 Walker B; other site 401614002418 D-loop; other site 401614002419 H-loop/switch region; other site 401614002420 FeS assembly protein SufD; Region: sufD; TIGR01981 401614002421 Amidinotransferase; Region: Amidinotransf; cl19186 401614002422 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 401614002423 catalytic residues [active] 401614002424 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 401614002425 Transcriptional regulators [Transcription]; Region: MarR; COG1846 401614002426 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 401614002427 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 401614002428 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 401614002429 hypothetical protein; Provisional; Region: PRK07505 401614002430 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 401614002431 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614002432 catalytic residue [active] 401614002433 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 401614002434 PAS fold; Region: PAS_4; pfam08448 401614002435 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 401614002436 active site 401614002437 8-oxo-dGMP binding site [chemical binding]; other site 401614002438 nudix motif; other site 401614002439 metal binding site [ion binding]; metal-binding site 401614002440 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 401614002441 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 401614002442 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 401614002443 Sel1 repeat; Region: Sel1; pfam08238 401614002444 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 401614002445 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 401614002446 Transglutaminase/protease-like homologues; Region: TGc; smart00460 401614002447 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 401614002448 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 401614002449 active site 401614002450 HIGH motif; other site 401614002451 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 401614002452 KMSKS motif; other site 401614002453 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 401614002454 tRNA binding surface [nucleotide binding]; other site 401614002455 Lipopolysaccharide-assembly; Region: LptE; cl01125 401614002456 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 401614002457 Mechanosensitive ion channel; Region: MS_channel; pfam00924 401614002458 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 401614002459 trimer interface [polypeptide binding]; other site 401614002460 active site 401614002461 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 401614002462 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 401614002463 Walker A motif; other site 401614002464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002465 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614002466 putative substrate translocation pore; other site 401614002467 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 401614002468 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 401614002469 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 401614002470 putative active site [active] 401614002471 catalytic site [active] 401614002472 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 401614002473 putative active site [active] 401614002474 catalytic site [active] 401614002475 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 401614002476 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 401614002477 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 401614002478 putative active site [active] 401614002479 catalytic site [active] 401614002480 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 401614002481 putative active site [active] 401614002482 catalytic site [active] 401614002483 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 401614002484 ZIP Zinc transporter; Region: Zip; cl00437 401614002485 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 401614002486 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 401614002487 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 401614002488 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 401614002489 metal binding site 2 [ion binding]; metal-binding site 401614002490 putative DNA binding helix; other site 401614002491 metal binding site 1 [ion binding]; metal-binding site 401614002492 dimer interface [polypeptide binding]; other site 401614002493 structural Zn2+ binding site [ion binding]; other site 401614002494 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 401614002495 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 401614002496 putative tRNA-binding site [nucleotide binding]; other site 401614002497 B3/4 domain; Region: B3_4; pfam03483 401614002498 tRNA synthetase B5 domain; Region: B5; smart00874 401614002499 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 401614002500 dimer interface [polypeptide binding]; other site 401614002501 motif 1; other site 401614002502 motif 3; other site 401614002503 motif 2; other site 401614002504 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 401614002505 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 401614002506 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 401614002507 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 401614002508 dimer interface [polypeptide binding]; other site 401614002509 motif 1; other site 401614002510 active site 401614002511 motif 2; other site 401614002512 motif 3; other site 401614002513 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 401614002514 EamA-like transporter family; Region: EamA; pfam00892 401614002515 EamA-like transporter family; Region: EamA; pfam00892 401614002516 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 401614002517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002518 putative substrate translocation pore; other site 401614002519 putative symporter YagG; Provisional; Region: PRK09669; cl15392 401614002520 MFS/sugar transport protein; Region: MFS_2; pfam13347 401614002521 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 401614002522 catalytic motif [active] 401614002523 Catalytic residue [active] 401614002524 Aspartyl protease; Region: Asp_protease_2; pfam13650 401614002525 inhibitor binding site; inhibition site 401614002526 catalytic motif [active] 401614002527 Catalytic residue [active] 401614002528 Active site flap [active] 401614002529 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 401614002530 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401614002531 non-specific DNA binding site [nucleotide binding]; other site 401614002532 salt bridge; other site 401614002533 sequence-specific DNA binding site [nucleotide binding]; other site 401614002534 hypothetical protein; Provisional; Region: PRK10356 401614002535 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 401614002536 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 401614002537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614002538 Walker A motif; other site 401614002539 ATP binding site [chemical binding]; other site 401614002540 Walker B motif; other site 401614002541 arginine finger; other site 401614002542 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 401614002543 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 401614002544 classical (c) SDRs; Region: SDR_c; cd05233 401614002545 NAD(P) binding site [chemical binding]; other site 401614002546 active site 401614002547 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 401614002548 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 401614002549 active site 401614002550 catalytic triad [active] 401614002551 oxyanion hole [active] 401614002552 switch loop; other site 401614002553 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 401614002554 putative active site pocket [active] 401614002555 dimerization interface [polypeptide binding]; other site 401614002556 putative catalytic residue [active] 401614002557 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 401614002558 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 401614002559 TPP-binding site; other site 401614002560 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 401614002561 PYR/PP interface [polypeptide binding]; other site 401614002562 dimer interface [polypeptide binding]; other site 401614002563 TPP binding site [chemical binding]; other site 401614002564 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 401614002565 GMP synthase; Reviewed; Region: guaA; PRK00074 401614002566 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 401614002567 AMP/PPi binding site [chemical binding]; other site 401614002568 candidate oxyanion hole; other site 401614002569 catalytic triad [active] 401614002570 potential glutamine specificity residues [chemical binding]; other site 401614002571 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 401614002572 ATP Binding subdomain [chemical binding]; other site 401614002573 Ligand Binding sites [chemical binding]; other site 401614002574 Dimerization subdomain; other site 401614002575 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 401614002576 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 401614002577 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 401614002578 dimerization interface 3.5A [polypeptide binding]; other site 401614002579 active site 401614002580 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 401614002581 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 401614002582 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 401614002583 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 401614002584 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 401614002585 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 401614002586 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 401614002587 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 401614002588 Walker A/P-loop; other site 401614002589 ATP binding site [chemical binding]; other site 401614002590 Q-loop/lid; other site 401614002591 ABC transporter signature motif; other site 401614002592 Walker B; other site 401614002593 D-loop; other site 401614002594 H-loop/switch region; other site 401614002595 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 401614002596 OstA-like protein; Region: OstA; cl00844 401614002597 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 401614002598 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 401614002599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401614002600 active site 401614002601 motif I; other site 401614002602 motif II; other site 401614002603 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 401614002604 dimer interface [polypeptide binding]; other site 401614002605 substrate binding site [chemical binding]; other site 401614002606 metal binding sites [ion binding]; metal-binding site 401614002607 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 401614002608 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 401614002609 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 401614002610 Protein of unknown function (DUF493); Region: DUF493; pfam04359 401614002611 lipoate-protein ligase B; Provisional; Region: PRK14342 401614002612 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 401614002613 putative symporter YagG; Provisional; Region: PRK09669; cl15392 401614002614 alpha-glucosidase; Provisional; Region: PRK10426 401614002615 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 401614002616 putative active site [active] 401614002617 putative catalytic site [active] 401614002618 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 401614002619 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401614002620 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 401614002621 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 401614002622 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 401614002623 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 401614002624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 401614002625 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 401614002626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 401614002627 DNA binding residues [nucleotide binding] 401614002628 CHC2 zinc finger; Region: zf-CHC2; pfam01807 401614002629 DNA primase; Validated; Region: dnaG; PRK05667 401614002630 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 401614002631 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 401614002632 active site 401614002633 metal binding site [ion binding]; metal-binding site 401614002634 interdomain interaction site; other site 401614002635 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 401614002636 Yqey-like protein; Region: YqeY; pfam09424 401614002637 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 401614002638 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 401614002639 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 401614002640 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 401614002641 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 401614002642 N-acetyl-D-glucosamine binding site [chemical binding]; other site 401614002643 catalytic residue [active] 401614002644 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 401614002645 active site 401614002646 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 401614002647 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 401614002648 Ligand Binding Site [chemical binding]; other site 401614002649 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 401614002650 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 401614002651 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 401614002652 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 401614002653 substrate binding pocket [chemical binding]; other site 401614002654 chain length determination region; other site 401614002655 substrate-Mg2+ binding site; other site 401614002656 catalytic residues [active] 401614002657 aspartate-rich region 1; other site 401614002658 active site lid residues [active] 401614002659 aspartate-rich region 2; other site 401614002660 PQ loop repeat; Region: PQ-loop; pfam04193 401614002661 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 401614002662 ligand-binding site [chemical binding]; other site 401614002663 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 401614002664 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 401614002665 CysD dimerization site [polypeptide binding]; other site 401614002666 G1 box; other site 401614002667 putative GEF interaction site [polypeptide binding]; other site 401614002668 GTP/Mg2+ binding site [chemical binding]; other site 401614002669 Switch I region; other site 401614002670 G2 box; other site 401614002671 G3 box; other site 401614002672 Switch II region; other site 401614002673 G4 box; other site 401614002674 G5 box; other site 401614002675 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 401614002676 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 401614002677 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 401614002678 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 401614002679 Active Sites [active] 401614002680 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 401614002681 Sulfotransferase domain; Region: Sulfotransfer_1; cl19239 401614002682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 401614002683 AAA domain; Region: AAA_17; pfam13207 401614002684 Walker A/P-loop; other site 401614002685 ATP binding site [chemical binding]; other site 401614002686 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 401614002687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401614002688 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 401614002689 Walker A/P-loop; other site 401614002690 ATP binding site [chemical binding]; other site 401614002691 Q-loop/lid; other site 401614002692 ABC transporter signature motif; other site 401614002693 Walker B; other site 401614002694 D-loop; other site 401614002695 H-loop/switch region; other site 401614002696 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 401614002697 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 401614002698 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 401614002699 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 401614002700 Ligand Binding Site [chemical binding]; other site 401614002701 Molecular Tunnel; other site 401614002702 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; cl19204 401614002703 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 401614002704 active site 401614002705 metal-binding site [ion binding] 401614002706 nucleotide-binding site [chemical binding]; other site 401614002707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 401614002708 Coenzyme A binding pocket [chemical binding]; other site 401614002709 preprotein translocase subunit SecA; Validated; Region: secA; CHL00122 401614002710 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 401614002711 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 401614002712 RNA binding surface [nucleotide binding]; other site 401614002713 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 401614002714 probable active site [active] 401614002715 Tetratricopeptide repeat; Region: TPR_12; pfam13424 401614002716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 401614002717 binding surface 401614002718 TPR motif; other site 401614002719 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 401614002720 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614002721 FeS/SAM binding site; other site 401614002722 replicative DNA helicase; Region: DnaB; TIGR00665 401614002723 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 401614002724 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 401614002725 Walker A motif; other site 401614002726 ATP binding site [chemical binding]; other site 401614002727 Walker B motif; other site 401614002728 DNA binding loops [nucleotide binding] 401614002729 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 401614002730 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 401614002731 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 401614002732 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 401614002733 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 401614002734 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 401614002735 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 401614002736 catalytic core [active] 401614002737 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 401614002738 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614002739 catalytic residue [active] 401614002740 cytidylate kinase; Provisional; Region: cmk; PRK00023 401614002741 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 401614002742 CMP-binding site; other site 401614002743 The sites determining sugar specificity; other site 401614002744 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 401614002745 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 401614002746 putative NAD(P) binding site [chemical binding]; other site 401614002747 homodimer interface [polypeptide binding]; other site 401614002748 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 401614002749 catalytic triad [active] 401614002750 dimer interface [polypeptide binding]; other site 401614002751 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 401614002752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 401614002753 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 401614002754 dimerization interface [polypeptide binding]; other site 401614002755 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 401614002756 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 401614002757 putative homodimer interface [polypeptide binding]; other site 401614002758 putative homotetramer interface [polypeptide binding]; other site 401614002759 putative allosteric switch controlling residues; other site 401614002760 putative metal binding site [ion binding]; other site 401614002761 putative homodimer-homodimer interface [polypeptide binding]; other site 401614002762 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 401614002763 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 401614002764 tetrameric interface [polypeptide binding]; other site 401614002765 NAD binding site [chemical binding]; other site 401614002766 catalytic residues [active] 401614002767 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 401614002768 TrkA-N domain; Region: TrkA_N; pfam02254 401614002769 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 401614002770 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 401614002771 putative metal binding site [ion binding]; other site 401614002772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 401614002773 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 401614002774 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 401614002775 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 401614002776 active site 401614002777 catalytic site [active] 401614002778 substrate binding site [chemical binding]; other site 401614002779 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 401614002780 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 401614002781 PhnA protein; Region: PhnA; pfam03831 401614002782 peroxidase; Provisional; Region: PRK15000 401614002783 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 401614002784 dimer interface [polypeptide binding]; other site 401614002785 decamer (pentamer of dimers) interface [polypeptide binding]; other site 401614002786 catalytic triad [active] 401614002787 peroxidatic and resolving cysteines [active] 401614002788 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 401614002789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401614002790 motif II; other site 401614002791 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 401614002792 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 401614002793 putative ATP binding site [chemical binding]; other site 401614002794 putative substrate interface [chemical binding]; other site 401614002795 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 401614002796 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 401614002797 N-acetyl-D-glucosamine binding site [chemical binding]; other site 401614002798 catalytic residue [active] 401614002799 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 401614002800 diiron binding motif [ion binding]; other site 401614002801 malate dehydrogenase; Reviewed; Region: PRK06223 401614002802 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 401614002803 NAD(P) binding site [chemical binding]; other site 401614002804 dimer interface [polypeptide binding]; other site 401614002805 tetramer (dimer of dimers) interface [polypeptide binding]; other site 401614002806 substrate binding site [chemical binding]; other site 401614002807 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 401614002808 Class I ribonucleotide reductase; Region: RNR_I; cd01679 401614002809 active site 401614002810 dimer interface [polypeptide binding]; other site 401614002811 catalytic residues [active] 401614002812 effector binding site; other site 401614002813 R2 peptide binding site; other site 401614002814 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 401614002815 GSH binding site [chemical binding]; other site 401614002816 catalytic residues [active] 401614002817 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 401614002818 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 401614002819 GSH binding site [chemical binding]; other site 401614002820 catalytic residues [active] 401614002821 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 401614002822 dimer interface [polypeptide binding]; other site 401614002823 putative radical transfer pathway; other site 401614002824 diiron center [ion binding]; other site 401614002825 tyrosyl radical; other site 401614002826 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 401614002827 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 401614002828 ABC transporter; Region: ABC_tran_2; pfam12848 401614002829 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 401614002830 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 401614002831 DJ-1 family protein; Region: not_thiJ; TIGR01383 401614002832 conserved cys residue [active] 401614002833 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 401614002834 active site 401614002835 DNA polymerase IV; Validated; Region: PRK02406 401614002836 DNA binding site [nucleotide binding] 401614002837 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 401614002838 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 401614002839 FMN binding site [chemical binding]; other site 401614002840 active site 401614002841 catalytic residues [active] 401614002842 substrate binding site [chemical binding]; other site 401614002843 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 401614002844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614002845 S-adenosylmethionine binding site [chemical binding]; other site 401614002846 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 401614002847 dimer interface [polypeptide binding]; other site 401614002848 active site 401614002849 metal binding site [ion binding]; metal-binding site 401614002850 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 401614002851 FAD binding domain; Region: FAD_binding_4; pfam01565 401614002852 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 401614002853 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 401614002854 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 401614002855 Cysteine-rich domain; Region: CCG; pfam02754 401614002856 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 401614002857 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 401614002858 active site 401614002859 substrate binding site [chemical binding]; other site 401614002860 FMN binding site [chemical binding]; other site 401614002861 putative catalytic residues [active] 401614002862 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 401614002863 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 401614002864 active site 401614002865 HIGH motif; other site 401614002866 dimer interface [polypeptide binding]; other site 401614002867 KMSKS motif; other site 401614002868 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 401614002869 RNA binding surface [nucleotide binding]; other site 401614002870 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 401614002871 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 401614002872 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 401614002873 active site 401614002874 HslU subunit interaction site [polypeptide binding]; other site 401614002875 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 401614002876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614002877 Walker A motif; other site 401614002878 ATP binding site [chemical binding]; other site 401614002879 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 401614002880 Walker B motif; other site 401614002881 arginine finger; other site 401614002882 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 401614002883 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 401614002884 POT family; Region: PTR2; cl17359 401614002885 Ion channel; Region: Ion_trans_2; pfam07885 401614002886 TrkA-N domain; Region: TrkA_N; pfam02254 401614002887 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 401614002888 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401614002889 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 401614002890 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 401614002891 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 401614002892 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 401614002893 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 401614002894 dimerization domain [polypeptide binding]; other site 401614002895 dimer interface [polypeptide binding]; other site 401614002896 catalytic residues [active] 401614002897 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 401614002898 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 401614002899 putative active site [active] 401614002900 catalytic residue [active] 401614002901 GTP-binding protein YchF; Reviewed; Region: PRK09601 401614002902 YchF GTPase; Region: YchF; cd01900 401614002903 G1 box; other site 401614002904 GTP/Mg2+ binding site [chemical binding]; other site 401614002905 Switch I region; other site 401614002906 G2 box; other site 401614002907 Switch II region; other site 401614002908 G3 box; other site 401614002909 G4 box; other site 401614002910 G5 box; other site 401614002911 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 401614002912 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 401614002913 Domain of unknown function DUF21; Region: DUF21; pfam01595 401614002914 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 401614002915 Transporter associated domain; Region: CorC_HlyC; pfam03471 401614002916 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 401614002917 5S rRNA interface [nucleotide binding]; other site 401614002918 CTC domain interface [polypeptide binding]; other site 401614002919 L16 interface [polypeptide binding]; other site 401614002920 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 401614002921 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 401614002922 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401614002923 active site 401614002924 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 401614002925 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 401614002926 putative active site [active] 401614002927 Zn binding site [ion binding]; other site 401614002928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002929 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614002930 putative substrate translocation pore; other site 401614002931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002932 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614002933 putative substrate translocation pore; other site 401614002934 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 401614002935 Mechanosensitive ion channel; Region: MS_channel; pfam00924 401614002936 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 401614002937 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 401614002938 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 401614002939 catalytic triad [active] 401614002940 conserved cis-peptide bond; other site 401614002941 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 401614002942 catalytic triad [active] 401614002943 conserved cis-peptide bond; other site 401614002944 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 401614002945 intersubunit interface [polypeptide binding]; other site 401614002946 active site 401614002947 Zn2+ binding site [ion binding]; other site 401614002948 histidine decarboxylase; Provisional; Region: PRK02769 401614002949 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614002950 catalytic residue [active] 401614002951 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 401614002952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 401614002953 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 401614002954 dimerization interface [polypeptide binding]; other site 401614002955 putative Zn2+ binding site [ion binding]; other site 401614002956 putative DNA binding site [nucleotide binding]; other site 401614002957 RmuC family; Region: RmuC; pfam02646 401614002958 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 401614002959 RuvA N terminal domain; Region: RuvA_N; pfam01330 401614002960 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 401614002961 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 401614002962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614002963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614002964 putative substrate translocation pore; other site 401614002965 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 401614002966 active site 401614002967 putative DNA-binding cleft [nucleotide binding]; other site 401614002968 dimer interface [polypeptide binding]; other site 401614002969 hypothetical protein; Validated; Region: PRK00110 401614002970 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 401614002971 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 401614002972 conserved cys residue [active] 401614002973 lipoyl synthase; Provisional; Region: PRK05481 401614002974 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 401614002975 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 401614002976 Ferritin-like domain; Region: Ferritin; pfam00210 401614002977 ferroxidase diiron center [ion binding]; other site 401614002978 POT family; Region: PTR2; cl17359 401614002979 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 401614002980 glutaredoxin 2; Provisional; Region: PRK10387 401614002981 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 401614002982 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 401614002983 N-terminal domain interface [polypeptide binding]; other site 401614002984 dimer interface [polypeptide binding]; other site 401614002985 substrate binding pocket (H-site) [chemical binding]; other site 401614002986 ferredoxin; Provisional; Region: PRK08764 401614002987 Putative Fe-S cluster; Region: FeS; cl17515 401614002988 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 401614002989 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 401614002990 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 401614002991 minor groove reading motif; other site 401614002992 helix-hairpin-helix signature motif; other site 401614002993 substrate binding pocket [chemical binding]; other site 401614002994 active site 401614002995 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 401614002996 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 401614002997 YccA-like proteins; Region: YccA_like; cd10433 401614002998 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 401614002999 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 401614003000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614003001 ATP binding site [chemical binding]; other site 401614003002 putative Mg++ binding site [ion binding]; other site 401614003003 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614003004 nucleotide binding region [chemical binding]; other site 401614003005 ATP-binding site [chemical binding]; other site 401614003006 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 401614003007 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 401614003008 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 401614003009 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 401614003010 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 401614003011 putative valine binding site [chemical binding]; other site 401614003012 dimer interface [polypeptide binding]; other site 401614003013 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 401614003014 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 401614003015 PYR/PP interface [polypeptide binding]; other site 401614003016 dimer interface [polypeptide binding]; other site 401614003017 TPP binding site [chemical binding]; other site 401614003018 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 401614003019 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 401614003020 TPP-binding site [chemical binding]; other site 401614003021 dimer interface [polypeptide binding]; other site 401614003022 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 401614003023 threonine synthase; Validated; Region: PRK06450 401614003024 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 401614003025 homodimer interface [polypeptide binding]; other site 401614003026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614003027 catalytic residue [active] 401614003028 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 401614003029 Predicted GTPase [General function prediction only]; Region: COG0218 401614003030 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 401614003031 G1 box; other site 401614003032 GTP/Mg2+ binding site [chemical binding]; other site 401614003033 Switch I region; other site 401614003034 G2 box; other site 401614003035 G3 box; other site 401614003036 Switch II region; other site 401614003037 G4 box; other site 401614003038 G5 box; other site 401614003039 Low molecular weight phosphatase family; Region: LMWPc; cd00115 401614003040 active site 401614003041 HflC protein; Region: hflC; TIGR01932 401614003042 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 401614003043 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 401614003044 HflK protein; Region: hflK; TIGR01933 401614003045 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 401614003046 hypothetical protein; Provisional; Region: PRK07588 401614003047 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 401614003048 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 401614003049 HflX GTPase family; Region: HflX; cd01878 401614003050 G1 box; other site 401614003051 GTP/Mg2+ binding site [chemical binding]; other site 401614003052 Switch I region; other site 401614003053 G2 box; other site 401614003054 G3 box; other site 401614003055 Switch II region; other site 401614003056 G4 box; other site 401614003057 G5 box; other site 401614003058 bacterial Hfq-like; Region: Hfq; cd01716 401614003059 hexamer interface [polypeptide binding]; other site 401614003060 Sm1 motif; other site 401614003061 RNA binding site [nucleotide binding]; other site 401614003062 Sm2 motif; other site 401614003063 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 401614003064 SurA N-terminal domain; Region: SurA_N_2; pfam13623 401614003065 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 401614003066 histone-like DNA-binding protein HU; Region: HU; cd13831 401614003067 dimer interface [polypeptide binding]; other site 401614003068 DNA binding site [nucleotide binding] 401614003069 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 401614003070 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 401614003071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614003072 Walker A motif; other site 401614003073 ATP binding site [chemical binding]; other site 401614003074 Walker B motif; other site 401614003075 arginine finger; other site 401614003076 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 401614003077 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 401614003078 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 401614003079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614003080 Walker A motif; other site 401614003081 ATP binding site [chemical binding]; other site 401614003082 Walker B motif; other site 401614003083 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 401614003084 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 401614003085 oligomer interface [polypeptide binding]; other site 401614003086 active site residues [active] 401614003087 trigger factor; Provisional; Region: tig; PRK01490 401614003088 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 401614003089 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 401614003090 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 401614003091 thymidine kinase; Provisional; Region: PRK04296 401614003092 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 401614003093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614003094 S-adenosylmethionine binding site [chemical binding]; other site 401614003095 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 401614003096 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 401614003097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614003098 FeS/SAM binding site; other site 401614003099 TRAM domain; Region: TRAM; pfam01938 401614003100 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 401614003101 PhoH-like protein; Region: PhoH; pfam02562 401614003102 metal-binding heat shock protein; Provisional; Region: PRK00016 401614003103 FOG: CBS domain [General function prediction only]; Region: COG0517 401614003104 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 401614003105 Transporter associated domain; Region: CorC_HlyC; smart01091 401614003106 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 401614003107 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 401614003108 putative active site [active] 401614003109 catalytic triad [active] 401614003110 putative dimer interface [polypeptide binding]; other site 401614003111 VirK protein; Region: VirK; pfam06903 401614003112 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 401614003113 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 401614003114 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 401614003115 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 401614003116 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 401614003117 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 401614003118 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 401614003119 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 401614003120 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 401614003121 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 401614003122 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 401614003123 active site 401614003124 substrate binding site [chemical binding]; other site 401614003125 Mg2+ binding site [ion binding]; other site 401614003126 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 401614003127 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 401614003128 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 401614003129 active site 401614003130 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 401614003131 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 401614003132 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 401614003133 Uncharacterized conserved protein [Function unknown]; Region: COG0327 401614003134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003135 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 401614003136 putative substrate translocation pore; other site 401614003137 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 401614003138 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 401614003139 dimer interface [polypeptide binding]; other site 401614003140 active site 401614003141 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 401614003142 dimer interface [polypeptide binding]; other site 401614003143 active site 401614003144 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 401614003145 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; cl19499 401614003146 Rubredoxin [Energy production and conversion]; Region: COG1773 401614003147 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 401614003148 iron binding site [ion binding]; other site 401614003149 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 401614003150 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614003151 catalytic residue [active] 401614003152 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 401614003153 active site clefts [active] 401614003154 zinc binding site [ion binding]; other site 401614003155 dimer interface [polypeptide binding]; other site 401614003156 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 401614003157 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 401614003158 active site 401614003159 homodimer interface [polypeptide binding]; other site 401614003160 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 401614003161 RNA/DNA hybrid binding site [nucleotide binding]; other site 401614003162 active site 401614003163 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 401614003164 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 401614003165 hinge; other site 401614003166 active site 401614003167 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 401614003168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 401614003169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 401614003170 DNA binding residues [nucleotide binding] 401614003171 Src Homology 3 domain superfamily; Region: SH3; cl17036 401614003172 peptide ligand binding site [polypeptide binding]; other site 401614003173 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 401614003174 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 401614003175 Protein export membrane protein; Region: SecD_SecF; pfam02355 401614003176 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 401614003177 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 401614003178 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 401614003179 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 401614003180 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 401614003181 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 401614003182 catalytic triad [active] 401614003183 conserved cis-peptide bond; other site 401614003184 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 401614003185 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 401614003186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 401614003187 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 401614003188 dimerization interface [polypeptide binding]; other site 401614003189 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 401614003190 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 401614003191 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 401614003192 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 401614003193 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 401614003194 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 401614003195 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 401614003196 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 401614003197 Walker A/P-loop; other site 401614003198 ATP binding site [chemical binding]; other site 401614003199 Q-loop/lid; other site 401614003200 ABC transporter signature motif; other site 401614003201 Walker B; other site 401614003202 D-loop; other site 401614003203 H-loop/switch region; other site 401614003204 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 401614003205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614003206 putative PBP binding loops; other site 401614003207 dimer interface [polypeptide binding]; other site 401614003208 ABC-ATPase subunit interface; other site 401614003209 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 401614003210 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 401614003211 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 401614003212 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 401614003213 active site residue [active] 401614003214 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 401614003215 active site residue [active] 401614003216 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 401614003217 homotrimer interaction site [polypeptide binding]; other site 401614003218 zinc binding site [ion binding]; other site 401614003219 CDP-binding sites; other site 401614003220 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614003221 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401614003222 cyanophycin synthetase; Provisional; Region: PRK14016 401614003223 ATP-grasp domain; Region: ATP-grasp_4; cl17255 401614003224 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614003225 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401614003226 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 401614003227 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 401614003228 putative MPT binding site; other site 401614003229 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 401614003230 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 401614003231 active site 401614003232 catalytic site [active] 401614003233 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 401614003234 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 401614003235 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 401614003236 Walker A motif; other site 401614003237 ATP binding site [chemical binding]; other site 401614003238 Walker B motif; other site 401614003239 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 401614003240 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 401614003241 Succinate dehydrogenase/Fumarate reductase transmembrane subunit; Region: Sdh_cyt; pfam01127 401614003242 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 401614003243 Predicted ATPase [General function prediction only]; Region: COG4637 401614003244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401614003245 Walker A/P-loop; other site 401614003246 ATP binding site [chemical binding]; other site 401614003247 AAA domain; Region: AAA_21; pfam13304 401614003248 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 401614003249 Ferrochelatase; Region: Ferrochelatase; pfam00762 401614003250 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 401614003251 C-terminal domain interface [polypeptide binding]; other site 401614003252 active site 401614003253 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 401614003254 active site 401614003255 N-terminal domain interface [polypeptide binding]; other site 401614003256 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 401614003257 DNA photolyase; Region: DNA_photolyase; pfam00875 401614003258 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 401614003259 PRC-barrel domain; Region: PRC; pfam05239 401614003260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003261 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 401614003262 NAD(P) binding site [chemical binding]; other site 401614003263 active site 401614003264 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 401614003265 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 401614003266 active site 401614003267 catalytic residues [active] 401614003268 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 401614003269 Flavoprotein; Region: Flavoprotein; cl19190 401614003270 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 401614003271 benzoate transport; Region: 2A0115; TIGR00895 401614003272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003273 putative substrate translocation pore; other site 401614003274 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 401614003275 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 401614003276 DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850 401614003277 Proline dehydrogenase; Region: Pro_dh; pfam01619 401614003278 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 401614003279 Glutamate binding site [chemical binding]; other site 401614003280 NAD binding site [chemical binding]; other site 401614003281 catalytic residues [active] 401614003282 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 401614003283 NAD(P) binding site [chemical binding]; other site 401614003284 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 401614003285 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 401614003286 active site 401614003287 dimer interface [polypeptide binding]; other site 401614003288 metal binding site [ion binding]; metal-binding site 401614003289 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 401614003290 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 401614003291 ADP binding site [chemical binding]; other site 401614003292 magnesium binding site [ion binding]; other site 401614003293 putative shikimate binding site; other site 401614003294 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 401614003295 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 401614003296 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 401614003297 Pilus assembly protein, PilP; Region: PilP; cl19831 401614003298 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 401614003299 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 401614003300 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 401614003301 adenylate kinase; Reviewed; Region: adk; PRK00279 401614003302 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 401614003303 AMP-binding site [chemical binding]; other site 401614003304 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 401614003305 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 401614003306 FAD binding domain; Region: FAD_binding_4; pfam01565 401614003307 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 401614003308 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 401614003309 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 401614003310 GTPase Era; Reviewed; Region: era; PRK00089 401614003311 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 401614003312 G1 box; other site 401614003313 GTP/Mg2+ binding site [chemical binding]; other site 401614003314 Switch I region; other site 401614003315 G2 box; other site 401614003316 Switch II region; other site 401614003317 G3 box; other site 401614003318 G4 box; other site 401614003319 G5 box; other site 401614003320 KH domain; Region: KH_2; pfam07650 401614003321 aspartate aminotransferase; Provisional; Region: PRK05764 401614003322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401614003323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614003324 homodimer interface [polypeptide binding]; other site 401614003325 catalytic residue [active] 401614003326 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 401614003327 putative active site [active] 401614003328 putative dimer interface [polypeptide binding]; other site 401614003329 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 401614003330 Glycoprotease family; Region: Peptidase_M22; pfam00814 401614003331 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 401614003332 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 401614003333 active site 401614003334 dimer interface [polypeptide binding]; other site 401614003335 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 401614003336 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 401614003337 GTP/Mg2+ binding site [chemical binding]; other site 401614003338 G4 box; other site 401614003339 G5 box; other site 401614003340 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 401614003341 G1 box; other site 401614003342 G1 box; other site 401614003343 GTP/Mg2+ binding site [chemical binding]; other site 401614003344 Switch I region; other site 401614003345 G2 box; other site 401614003346 G2 box; other site 401614003347 Switch I region; other site 401614003348 G3 box; other site 401614003349 G3 box; other site 401614003350 Switch II region; other site 401614003351 Switch II region; other site 401614003352 G4 box; other site 401614003353 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 401614003354 Sel1-like repeats; Region: SEL1; smart00671 401614003355 Sel1-like repeats; Region: SEL1; smart00671 401614003356 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 401614003357 Sel1 repeat; Region: Sel1; pfam08238 401614003358 HsdM N-terminal domain; Region: HsdM_N; pfam12161 401614003359 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 401614003360 Methyltransferase domain; Region: Methyltransf_26; pfam13659 401614003361 Transposase IS200 like; Region: Y1_Tnp; cl00848 401614003362 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 401614003363 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 401614003364 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 401614003365 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 401614003366 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 401614003367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614003368 ATP binding site [chemical binding]; other site 401614003369 putative Mg++ binding site [ion binding]; other site 401614003370 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 401614003371 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 401614003372 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 401614003373 G1 box; other site 401614003374 putative GEF interaction site [polypeptide binding]; other site 401614003375 GTP/Mg2+ binding site [chemical binding]; other site 401614003376 Switch I region; other site 401614003377 G2 box; other site 401614003378 G3 box; other site 401614003379 Switch II region; other site 401614003380 G4 box; other site 401614003381 G5 box; other site 401614003382 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 401614003383 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 401614003384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614003385 S-adenosylmethionine binding site [chemical binding]; other site 401614003386 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 401614003387 VacJ like lipoprotein; Region: VacJ; cl01073 401614003388 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 401614003389 FAD dependent oxidoreductase; Region: DAO; pfam01266 401614003390 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 401614003391 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 401614003392 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 401614003393 putative coenzyme Q binding site [chemical binding]; other site 401614003394 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 401614003395 SmpB-tmRNA interface; other site 401614003396 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 401614003397 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 401614003398 Ligand Binding Site [chemical binding]; other site 401614003399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003400 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614003401 putative substrate translocation pore; other site 401614003402 Domain of Unknown Function with PDB structure (DUF3864); Region: DUF3864; pfam12980 401614003403 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 401614003404 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 401614003405 generic binding surface II; other site 401614003406 generic binding surface I; other site 401614003407 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 401614003408 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 401614003409 metal binding site [ion binding]; metal-binding site 401614003410 dimer interface [polypeptide binding]; other site 401614003411 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 401614003412 putative dimer interface [polypeptide binding]; other site 401614003413 putative active site [active] 401614003414 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 401614003415 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 401614003416 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 401614003417 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 401614003418 Uncharacterized conserved protein [Function unknown]; Region: COG2308 401614003419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003420 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614003421 putative substrate translocation pore; other site 401614003422 glutamate racemase; Provisional; Region: PRK00865 401614003423 Nuclease-related domain; Region: NERD; pfam08378 401614003424 excinuclease ABC subunit B; Provisional; Region: PRK05298 401614003425 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614003426 ATP binding site [chemical binding]; other site 401614003427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614003428 nucleotide binding region [chemical binding]; other site 401614003429 ATP-binding site [chemical binding]; other site 401614003430 Ultra-violet resistance protein B; Region: UvrB; pfam12344 401614003431 UvrB/uvrC motif; Region: UVR; pfam02151 401614003432 exonuclease I; Provisional; Region: sbcB; PRK11779 401614003433 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 401614003434 active site 401614003435 catalytic site [active] 401614003436 substrate binding site [chemical binding]; other site 401614003437 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 401614003438 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 401614003439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614003440 NAD(P) binding site [chemical binding]; other site 401614003441 active site 401614003442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614003443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 401614003444 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 401614003445 putative effector binding pocket; other site 401614003446 dimerization interface [polypeptide binding]; other site 401614003447 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 401614003448 Predicted membrane protein [Function unknown]; Region: COG1289 401614003449 reticulocyte binding/rhoptry protein; Region: 235kDa-fam; TIGR01612 401614003450 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 401614003451 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 401614003452 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 401614003453 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 401614003454 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 401614003455 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 401614003456 tetramer (dimer of dimers) interface [polypeptide binding]; other site 401614003457 active site 401614003458 dimer interface [polypeptide binding]; other site 401614003459 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 401614003460 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 401614003461 active site 401614003462 Zn binding site [ion binding]; other site 401614003463 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 401614003464 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 401614003465 23S rRNA binding site [nucleotide binding]; other site 401614003466 L21 binding site [polypeptide binding]; other site 401614003467 L13 binding site [polypeptide binding]; other site 401614003468 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 401614003469 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 401614003470 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 401614003471 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 401614003472 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 401614003473 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 401614003474 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 401614003475 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 401614003476 active site 401614003477 dimer interface [polypeptide binding]; other site 401614003478 motif 1; other site 401614003479 motif 2; other site 401614003480 motif 3; other site 401614003481 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 401614003482 anticodon binding site; other site 401614003483 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 401614003484 Chitin binding domain; Region: Chitin_bind_3; pfam03067 401614003485 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 401614003486 aromatic chitin/cellulose binding site residues [chemical binding]; other site 401614003487 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 401614003488 lipoyl attachment site [posttranslational modification]; other site 401614003489 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 401614003490 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 401614003491 active site 401614003492 homodimer interface [polypeptide binding]; other site 401614003493 hypothetical protein; Validated; Region: PRK00153 401614003494 recombination protein RecR; Provisional; Region: PRK13844 401614003495 RecR protein; Region: RecR; pfam02132 401614003496 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 401614003497 putative active site [active] 401614003498 putative metal-binding site [ion binding]; other site 401614003499 tetramer interface [polypeptide binding]; other site 401614003500 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 401614003501 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 401614003502 Zn2+ binding site [ion binding]; other site 401614003503 Mg2+ binding site [ion binding]; other site 401614003504 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 401614003505 synthetase active site [active] 401614003506 NTP binding site [chemical binding]; other site 401614003507 metal binding site [ion binding]; metal-binding site 401614003508 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 401614003509 ACT domain; Region: ACT_4; pfam13291 401614003510 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 401614003511 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 401614003512 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 401614003513 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401614003514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003515 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614003516 putative substrate translocation pore; other site 401614003517 Asparaginase [Amino acid transport and metabolism]; Region: COG1446 401614003518 active site 401614003519 dimer interface [polypeptide binding]; other site 401614003520 catalytic nucleophile [active] 401614003521 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 401614003522 proposed catalytic triad [active] 401614003523 active site nucleophile [active] 401614003524 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 401614003525 substrate binding site [chemical binding]; other site 401614003526 ATP binding site [chemical binding]; other site 401614003527 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 401614003528 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 401614003529 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401614003530 motif II; other site 401614003531 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 401614003532 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401614003533 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 401614003534 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401614003535 active site 401614003536 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 401614003537 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401614003538 active site 401614003539 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 401614003540 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 401614003541 Methyltransferase domain; Region: Methyltransf_23; pfam13489 401614003542 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 401614003543 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 401614003544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401614003545 Walker A/P-loop; other site 401614003546 ATP binding site [chemical binding]; other site 401614003547 Q-loop/lid; other site 401614003548 ABC transporter signature motif; other site 401614003549 Walker B; other site 401614003550 D-loop; other site 401614003551 H-loop/switch region; other site 401614003552 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401614003553 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 401614003554 putative ADP-binding pocket [chemical binding]; other site 401614003555 UDP-glucose 4-epimerase; Region: PLN02240 401614003556 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 401614003557 NAD binding site [chemical binding]; other site 401614003558 homodimer interface [polypeptide binding]; other site 401614003559 active site 401614003560 substrate binding site [chemical binding]; other site 401614003561 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 401614003562 CoA binding domain; Region: CoA_binding; cl17356 401614003563 Bacterial sugar transferase; Region: Bac_transf; pfam02397 401614003564 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 401614003565 substrate binding site [chemical binding]; other site 401614003566 hexamer interface [polypeptide binding]; other site 401614003567 metal binding site [ion binding]; metal-binding site 401614003568 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 401614003569 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 401614003570 putative active site [active] 401614003571 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 401614003572 Predicted membrane protein [Function unknown]; Region: COG2259 401614003573 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 401614003574 hypothetical protein; Provisional; Region: PRK05409 401614003575 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 401614003576 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 401614003577 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 401614003578 NAD binding site [chemical binding]; other site 401614003579 homotetramer interface [polypeptide binding]; other site 401614003580 homodimer interface [polypeptide binding]; other site 401614003581 substrate binding site [chemical binding]; other site 401614003582 active site 401614003583 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 401614003584 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 401614003585 dimer interface [polypeptide binding]; other site 401614003586 active site 401614003587 metal binding site [ion binding]; metal-binding site 401614003588 glutathione binding site [chemical binding]; other site 401614003589 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 401614003590 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 401614003591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401614003592 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 401614003593 active site 401614003594 motif I; other site 401614003595 motif II; other site 401614003596 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 401614003597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 401614003598 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 401614003599 Squalene epoxidase; Region: SE; cl17314 401614003600 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 401614003601 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 401614003602 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 401614003603 BolA-like protein; Region: BolA; cl00386 401614003604 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 401614003605 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 401614003606 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 401614003607 Recombination protein O N terminal; Region: RecO_N; pfam11967 401614003608 Recombination protein O C terminal; Region: RecO_C; pfam02565 401614003609 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 401614003610 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401614003611 catalytic residue [active] 401614003612 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 401614003613 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 401614003614 homodimer interface [polypeptide binding]; other site 401614003615 oligonucleotide binding site [chemical binding]; other site 401614003616 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 401614003617 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 401614003618 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 401614003619 dimerization interface [polypeptide binding]; other site 401614003620 active site 401614003621 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 401614003622 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 401614003623 ligand binding site [chemical binding]; other site 401614003624 NAD binding site [chemical binding]; other site 401614003625 tetramer interface [polypeptide binding]; other site 401614003626 catalytic site [active] 401614003627 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 401614003628 L-serine binding site [chemical binding]; other site 401614003629 ACT domain interface; other site 401614003630 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 401614003631 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 401614003632 Ligand Binding Site [chemical binding]; other site 401614003633 TilS substrate C-terminal domain; Region: TilS_C; smart00977 401614003634 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 401614003635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003636 putative substrate translocation pore; other site 401614003637 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 401614003638 active site 401614003639 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 401614003640 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401614003641 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 401614003642 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 401614003643 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 401614003644 Ligand binding site; other site 401614003645 metal-binding site 401614003646 hypothetical protein; Provisional; Region: PRK05255 401614003647 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 401614003648 dimer interface [polypeptide binding]; other site 401614003649 active site 401614003650 glycine-pyridoxal phosphate binding site [chemical binding]; other site 401614003651 folate binding site [chemical binding]; other site 401614003652 seryl-tRNA synthetase; Provisional; Region: PRK05431 401614003653 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 401614003654 FAD binding domain; Region: FAD_binding_4; pfam01565 401614003655 Berberine and berberine like; Region: BBE; pfam08031 401614003656 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 401614003657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 401614003658 TPR motif; other site 401614003659 binding surface 401614003660 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 401614003661 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 401614003662 RNA binding surface [nucleotide binding]; other site 401614003663 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 401614003664 active site 401614003665 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 401614003666 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 401614003667 Permease; Region: Permease; pfam02405 401614003668 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 401614003669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401614003670 Walker A/P-loop; other site 401614003671 ATP binding site [chemical binding]; other site 401614003672 Q-loop/lid; other site 401614003673 ABC transporter signature motif; other site 401614003674 Walker B; other site 401614003675 D-loop; other site 401614003676 H-loop/switch region; other site 401614003677 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 401614003678 mce related protein; Region: MCE; pfam02470 401614003679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 401614003680 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 401614003681 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 401614003682 POT family; Region: PTR2; cl17359 401614003683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003684 putative substrate translocation pore; other site 401614003685 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 401614003686 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 401614003687 acyl-activating enzyme (AAE) consensus motif; other site 401614003688 putative AMP binding site [chemical binding]; other site 401614003689 putative active site [active] 401614003690 putative CoA binding site [chemical binding]; other site 401614003691 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 401614003692 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 401614003693 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 401614003694 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 401614003695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003696 putative substrate translocation pore; other site 401614003697 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 401614003698 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 401614003699 HlyD family secretion protein; Region: HlyD_3; pfam13437 401614003700 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 401614003701 Outer membrane efflux protein; Region: OEP; pfam02321 401614003702 Outer membrane efflux protein; Region: OEP; pfam02321 401614003703 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 401614003704 homodimer interface [polypeptide binding]; other site 401614003705 NAD binding pocket [chemical binding]; other site 401614003706 ATP binding pocket [chemical binding]; other site 401614003707 Mg binding site [ion binding]; other site 401614003708 active-site loop [active] 401614003709 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 401614003710 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cd00133 401614003711 active site 401614003712 P-loop; other site 401614003713 phosphorylation site [posttranslational modification] 401614003714 Pirin-related protein [General function prediction only]; Region: COG1741 401614003715 Pirin; Region: Pirin; pfam02678 401614003716 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614003717 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 401614003718 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 401614003719 putative effector binding pocket; other site 401614003720 dimerization interface [polypeptide binding]; other site 401614003721 chaperone protein DnaJ; Provisional; Region: PRK10767 401614003722 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 401614003723 HSP70 interaction site [polypeptide binding]; other site 401614003724 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 401614003725 substrate binding site [polypeptide binding]; other site 401614003726 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 401614003727 Zn binding sites [ion binding]; other site 401614003728 dimer interface [polypeptide binding]; other site 401614003729 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 401614003730 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 401614003731 nucleotide binding site [chemical binding]; other site 401614003732 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 401614003733 dimer interface [polypeptide binding]; other site 401614003734 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 401614003735 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 401614003736 MltA specific insert domain; Region: MltA; smart00925 401614003737 3D domain; Region: 3D; pfam06725 401614003738 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 401614003739 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 401614003740 23S rRNA interface [nucleotide binding]; other site 401614003741 L3 interface [polypeptide binding]; other site 401614003742 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 401614003743 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 401614003744 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 401614003745 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 401614003746 Na binding site [ion binding]; other site 401614003747 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 401614003748 RNA/DNA hybrid binding site [nucleotide binding]; other site 401614003749 active site 401614003750 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 401614003751 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 401614003752 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 401614003753 active site 401614003754 phosphorylation site [posttranslational modification] 401614003755 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 401614003756 30S subunit binding site; other site 401614003757 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 401614003758 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 401614003759 trmE is a tRNA modification GTPase; Region: trmE; cd04164 401614003760 G1 box; other site 401614003761 GTP/Mg2+ binding site [chemical binding]; other site 401614003762 Switch I region; other site 401614003763 G2 box; other site 401614003764 Switch II region; other site 401614003765 G3 box; other site 401614003766 G4 box; other site 401614003767 G5 box; other site 401614003768 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 401614003769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614003770 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 401614003771 putative DNA binding site [nucleotide binding]; other site 401614003772 putative Zn2+ binding site [ion binding]; other site 401614003773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 401614003774 dimerization interface [polypeptide binding]; other site 401614003775 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 401614003776 active site 401614003777 cysteine synthase; Region: PLN02565 401614003778 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 401614003779 dimer interface [polypeptide binding]; other site 401614003780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614003781 catalytic residue [active] 401614003782 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 401614003783 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 401614003784 DNA polymerase III PolC; Validated; Region: polC; PRK00448 401614003785 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 401614003786 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 401614003787 Intracellular growth locus C protein; Region: IglC; pfam11550 401614003788 Protein of unknown function (DUF877); Region: DUF877; pfam05943 401614003789 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 401614003790 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 401614003791 Trehalase; Region: Trehalase; cl17346 401614003792 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 401614003793 intersubunit interface [polypeptide binding]; other site 401614003794 active site 401614003795 zinc binding site [ion binding]; other site 401614003796 Na+ binding site [ion binding]; other site 401614003797 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 401614003798 pyruvate kinase; Provisional; Region: PRK05826 401614003799 domain interfaces; other site 401614003800 active site 401614003801 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 401614003802 substrate binding site [chemical binding]; other site 401614003803 hinge regions; other site 401614003804 ADP binding site [chemical binding]; other site 401614003805 catalytic site [active] 401614003806 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 401614003807 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 401614003808 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 401614003809 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 401614003810 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 401614003811 TPP-binding site [chemical binding]; other site 401614003812 dimer interface [polypeptide binding]; other site 401614003813 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 401614003814 PYR/PP interface [polypeptide binding]; other site 401614003815 dimer interface [polypeptide binding]; other site 401614003816 TPP binding site [chemical binding]; other site 401614003817 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 401614003818 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 401614003819 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 401614003820 putative phosphate acyltransferase; Provisional; Region: PRK05331 401614003821 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 401614003822 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 401614003823 dimer interface [polypeptide binding]; other site 401614003824 active site 401614003825 CoA binding pocket [chemical binding]; other site 401614003826 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 401614003827 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 401614003828 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 401614003829 NAD(P) binding site [chemical binding]; other site 401614003830 homotetramer interface [polypeptide binding]; other site 401614003831 homodimer interface [polypeptide binding]; other site 401614003832 active site 401614003833 acyl carrier protein; Provisional; Region: acpP; PRK00982 401614003834 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 401614003835 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 401614003836 dimer interface [polypeptide binding]; other site 401614003837 active site 401614003838 YCII-related domain; Region: YCII; cl00999 401614003839 Uncharacterized conserved protein [Function unknown]; Region: COG4121 401614003840 putative transporter; Provisional; Region: PRK03699 401614003841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003842 putative substrate translocation pore; other site 401614003843 Predicted membrane protein [Function unknown]; Region: COG2855 401614003844 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 401614003845 active site 401614003846 dimerization interface [polypeptide binding]; other site 401614003847 16S rRNA methyltransferase B; Provisional; Region: PRK10901 401614003848 NusB family; Region: NusB; pfam01029 401614003849 putative RNA binding site [nucleotide binding]; other site 401614003850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614003851 S-adenosylmethionine binding site [chemical binding]; other site 401614003852 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 401614003853 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 401614003854 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 401614003855 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 401614003856 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 401614003857 nucleotide binding pocket [chemical binding]; other site 401614003858 K-X-D-G motif; other site 401614003859 catalytic site [active] 401614003860 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 401614003861 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 401614003862 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 401614003863 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 401614003864 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 401614003865 Dimer interface [polypeptide binding]; other site 401614003866 BRCT sequence motif; other site 401614003867 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 401614003868 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 401614003869 active site 401614003870 oligomerization interface [polypeptide binding]; other site 401614003871 metal binding site [ion binding]; metal-binding site 401614003872 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 401614003873 active site 401614003874 nucleotide binding site [chemical binding]; other site 401614003875 HIGH motif; other site 401614003876 KMSKS motif; other site 401614003877 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 401614003878 tetramerization interface [polypeptide binding]; other site 401614003879 active site 401614003880 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 401614003881 nucleotide binding site [chemical binding]; other site 401614003882 Type III pantothenate kinase; Region: Pan_kinase; cl17198 401614003883 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 401614003884 AAA domain; Region: AAA_30; pfam13604 401614003885 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 401614003886 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 401614003887 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 401614003888 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 401614003889 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 401614003890 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 401614003891 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 401614003892 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 401614003893 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 401614003894 active site 401614003895 FMN binding site [chemical binding]; other site 401614003896 substrate binding site [chemical binding]; other site 401614003897 3Fe-4S cluster binding site [ion binding]; other site 401614003898 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 401614003899 EamA-like transporter family; Region: EamA; pfam00892 401614003900 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 401614003901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401614003902 non-specific DNA binding site [nucleotide binding]; other site 401614003903 salt bridge; other site 401614003904 sequence-specific DNA binding site [nucleotide binding]; other site 401614003905 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 401614003906 Catalytic site [active] 401614003907 FeoA domain; Region: FeoA; cl00838 401614003908 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 401614003909 Sporulation related domain; Region: SPOR; pfam05036 401614003910 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 401614003911 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 401614003912 intersubunit interface [polypeptide binding]; other site 401614003913 ATP12 chaperone protein; Region: ATP12; cl02228 401614003914 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 401614003915 active site 401614003916 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 401614003917 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 401614003918 prolyl-tRNA synthetase; Provisional; Region: PRK09194 401614003919 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 401614003920 dimer interface [polypeptide binding]; other site 401614003921 motif 1; other site 401614003922 active site 401614003923 motif 2; other site 401614003924 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 401614003925 putative deacylase active site [active] 401614003926 motif 3; other site 401614003927 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 401614003928 anticodon binding site; other site 401614003929 Transposase IS200 like; Region: Y1_Tnp; pfam01797 401614003930 methionine aminotransferase; Validated; Region: PRK09082 401614003931 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401614003932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614003933 homodimer interface [polypeptide binding]; other site 401614003934 catalytic residue [active] 401614003935 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 401614003936 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 401614003937 active site 401614003938 catalytic triad [active] 401614003939 dimer interface [polypeptide binding]; other site 401614003940 transcription antitermination factor NusB; Region: nusB; TIGR01951 401614003941 putative RNA binding site [nucleotide binding]; other site 401614003942 hypothetical protein; Provisional; Region: PRK05170 401614003943 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 401614003944 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 401614003945 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 401614003946 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 401614003947 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 401614003948 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 401614003949 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401614003950 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 401614003951 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 401614003952 active site residue [active] 401614003953 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 401614003954 active site residue [active] 401614003955 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 401614003956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 401614003957 putative DNA binding site [nucleotide binding]; other site 401614003958 putative Zn2+ binding site [ion binding]; other site 401614003959 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 401614003960 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 401614003961 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 401614003962 CRISPR-associated protein Cpf1, subtype PREFRAN; Region: cas_Cpf1; TIGR04330 401614003963 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 401614003964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 401614003965 Coenzyme A binding pocket [chemical binding]; other site 401614003966 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 401614003967 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 401614003968 ATP-NAD kinase; Region: NAD_kinase; cl01255 401614003969 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 401614003970 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 401614003971 Ligand binding site; other site 401614003972 Putative Catalytic site; other site 401614003973 DXD motif; other site 401614003974 inner membrane transport permease; Provisional; Region: PRK15066 401614003975 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 401614003976 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 401614003977 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 401614003978 Walker A/P-loop; other site 401614003979 ATP binding site [chemical binding]; other site 401614003980 Q-loop/lid; other site 401614003981 ABC transporter signature motif; other site 401614003982 Walker B; other site 401614003983 D-loop; other site 401614003984 H-loop/switch region; other site 401614003985 hypothetical protein; Provisional; Region: PRK10621 401614003986 Cupin domain; Region: Cupin_2; cl17218 401614003987 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 401614003988 active site 401614003989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614003990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614003991 putative substrate translocation pore; other site 401614003992 Ferritin-like domain; Region: Ferritin; pfam00210 401614003993 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 401614003994 dinuclear metal binding motif [ion binding]; other site 401614003995 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 401614003996 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 401614003997 dimer interface [polypeptide binding]; other site 401614003998 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 401614003999 recombination factor protein RarA; Reviewed; Region: PRK13342 401614004000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614004001 Walker A motif; other site 401614004002 ATP binding site [chemical binding]; other site 401614004003 Walker B motif; other site 401614004004 recombination factor protein RarA; Provisional; Region: PRK14700 401614004005 arginine finger; other site 401614004006 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 401614004007 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 401614004008 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 401614004009 catalytic residues [active] 401614004010 transcription termination factor Rho; Provisional; Region: rho; PRK09376 401614004011 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 401614004012 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 401614004013 RNA binding site [nucleotide binding]; other site 401614004014 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 401614004015 multimer interface [polypeptide binding]; other site 401614004016 Walker A motif; other site 401614004017 ATP binding site [chemical binding]; other site 401614004018 Walker B motif; other site 401614004019 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 401614004020 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 401614004021 active site 401614004022 substrate binding site [chemical binding]; other site 401614004023 metal binding site [ion binding]; metal-binding site 401614004024 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 401614004025 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 401614004026 Substrate binding site; other site 401614004027 Cupin domain; Region: Cupin_2; cl17218 401614004028 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 401614004029 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 401614004030 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 401614004031 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 401614004032 active site 401614004033 dimer interface [polypeptide binding]; other site 401614004034 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 401614004035 Ligand Binding Site [chemical binding]; other site 401614004036 Molecular Tunnel; other site 401614004037 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401614004038 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 401614004039 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401614004040 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 401614004041 putative ADP-binding pocket [chemical binding]; other site 401614004042 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 401614004043 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 401614004044 NAD binding site [chemical binding]; other site 401614004045 substrate binding site [chemical binding]; other site 401614004046 homodimer interface [polypeptide binding]; other site 401614004047 active site 401614004048 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 401614004049 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 401614004050 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 401614004051 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 401614004052 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 401614004053 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401614004054 putative ADP-binding pocket [chemical binding]; other site 401614004055 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 401614004056 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 401614004057 putative trimer interface [polypeptide binding]; other site 401614004058 putative CoA binding site [chemical binding]; other site 401614004059 Bacterial sugar transferase; Region: Bac_transf; pfam02397 401614004060 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 401614004061 inhibitor-cofactor binding pocket; inhibition site 401614004062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614004063 catalytic residue [active] 401614004064 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 401614004065 CoA binding domain; Region: CoA_binding; cl17356 401614004066 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 401614004067 NAD(P) binding site [chemical binding]; other site 401614004068 homodimer interface [polypeptide binding]; other site 401614004069 substrate binding site [chemical binding]; other site 401614004070 active site 401614004071 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 401614004072 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614004073 ATP binding site [chemical binding]; other site 401614004074 putative Mg++ binding site [ion binding]; other site 401614004075 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401614004076 nucleotide binding region [chemical binding]; other site 401614004077 ATP-binding site [chemical binding]; other site 401614004078 Helicase associated domain (HA2); Region: HA2; pfam04408 401614004079 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 401614004080 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 401614004081 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 401614004082 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 401614004083 catalytic residues [active] 401614004084 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 401614004085 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 401614004086 acyl-activating enzyme (AAE) consensus motif; other site 401614004087 putative AMP binding site [chemical binding]; other site 401614004088 putative active site [active] 401614004089 putative CoA binding site [chemical binding]; other site 401614004090 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 401614004091 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 401614004092 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 401614004093 active site 401614004094 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 401614004095 Acyl CoA binding protein; Region: ACBP; pfam00887 401614004096 acyl-CoA binding pocket [chemical binding]; other site 401614004097 CoA binding site [chemical binding]; other site 401614004098 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 401614004099 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 401614004100 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 401614004101 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 401614004102 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 401614004103 substrate binding site [chemical binding]; other site 401614004104 oxyanion hole (OAH) forming residues; other site 401614004105 trimer interface [polypeptide binding]; other site 401614004106 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 401614004107 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 401614004108 dimer interface [polypeptide binding]; other site 401614004109 active site 401614004110 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 401614004111 CoenzymeA binding site [chemical binding]; other site 401614004112 subunit interaction site [polypeptide binding]; other site 401614004113 PHB binding site; other site 401614004114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004115 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 401614004116 putative substrate translocation pore; other site 401614004117 Protein of unknown function (DUF465); Region: DUF465; cl01070 401614004118 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 401614004119 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 401614004120 active site 401614004121 ornithine cyclodeaminase; Validated; Region: PRK07589 401614004122 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 401614004123 Amidinotransferase; Region: Amidinotransf; pfam02274 401614004124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 401614004125 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 401614004126 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 401614004127 hypothetical protein; Provisional; Region: PRK11281 401614004128 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 401614004129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401614004130 active site 401614004131 phosphorylation site [posttranslational modification] 401614004132 intermolecular recognition site; other site 401614004133 dimerization interface [polypeptide binding]; other site 401614004134 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 401614004135 DNA binding site [nucleotide binding] 401614004136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 401614004137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 401614004138 dimer interface [polypeptide binding]; other site 401614004139 phosphorylation site [posttranslational modification] 401614004140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401614004141 ATP binding site [chemical binding]; other site 401614004142 Mg2+ binding site [ion binding]; other site 401614004143 G-X-G motif; other site 401614004144 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 401614004145 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 401614004146 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 401614004147 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 401614004148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614004149 S-adenosylmethionine binding site [chemical binding]; other site 401614004150 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 401614004151 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 401614004152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401614004153 NAD(P) binding site [chemical binding]; other site 401614004154 active site 401614004155 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 401614004156 Di-iron ligands [ion binding]; other site 401614004157 ribonuclease R; Region: RNase_R; TIGR02063 401614004158 RNB domain; Region: RNB; pfam00773 401614004159 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 401614004160 RNA binding site [nucleotide binding]; other site 401614004161 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 401614004162 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 401614004163 RNA binding site [nucleotide binding]; other site 401614004164 active site 401614004165 ribonuclease III; Reviewed; Region: rnc; PRK00102 401614004166 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 401614004167 dimerization interface [polypeptide binding]; other site 401614004168 active site 401614004169 metal binding site [ion binding]; metal-binding site 401614004170 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 401614004171 dsRNA binding site [nucleotide binding]; other site 401614004172 signal peptidase I; Provisional; Region: PRK10861 401614004173 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 401614004174 Catalytic site [active] 401614004175 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 401614004176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401614004177 active site 401614004178 phosphorylation site [posttranslational modification] 401614004179 intermolecular recognition site; other site 401614004180 dimerization interface [polypeptide binding]; other site 401614004181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 401614004182 DNA binding site [nucleotide binding] 401614004183 PrpF protein; Region: PrpF; cl19418 401614004184 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 401614004185 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 401614004186 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 401614004187 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 401614004188 active site 401614004189 dimerization interface [polypeptide binding]; other site 401614004190 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 401614004191 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 401614004192 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 401614004193 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 401614004194 substrate binding pocket [chemical binding]; other site 401614004195 chain length determination region; other site 401614004196 substrate-Mg2+ binding site; other site 401614004197 catalytic residues [active] 401614004198 aspartate-rich region 1; other site 401614004199 active site lid residues [active] 401614004200 aspartate-rich region 2; other site 401614004201 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 401614004202 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 401614004203 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 401614004204 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 401614004205 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 401614004206 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 401614004207 active site 401614004208 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 401614004209 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 401614004210 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 401614004211 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 401614004212 active site 401614004213 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 401614004214 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 401614004215 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 401614004216 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 401614004217 trimer interface [polypeptide binding]; other site 401614004218 active site 401614004219 UDP-GlcNAc binding site [chemical binding]; other site 401614004220 lipid binding site [chemical binding]; lipid-binding site 401614004221 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 401614004222 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 401614004223 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 401614004224 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 401614004225 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 401614004226 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 401614004227 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 401614004228 Surface antigen; Region: Bac_surface_Ag; pfam01103 401614004229 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 401614004230 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 401614004231 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 401614004232 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 401614004233 DNA gyrase subunit A; Validated; Region: PRK05560 401614004234 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 401614004235 CAP-like domain; other site 401614004236 active site 401614004237 primary dimer interface [polypeptide binding]; other site 401614004238 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401614004239 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401614004240 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401614004241 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401614004242 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401614004243 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401614004244 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 401614004245 aromatic chitin/cellulose binding site residues [chemical binding]; other site 401614004246 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 401614004247 ligand binding site [chemical binding]; other site 401614004248 active site 401614004249 UGI interface [polypeptide binding]; other site 401614004250 catalytic site [active] 401614004251 Restriction endonuclease [Defense mechanisms]; Region: COG3587 401614004252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401614004253 ATP binding site [chemical binding]; other site 401614004254 putative Mg++ binding site [ion binding]; other site 401614004255 Virulence protein RhuM family; Region: Virulence_RhuM; cl19850 401614004256 Fic/DOC family; Region: Fic; pfam02661 401614004257 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 401614004258 DNA methylase; Region: N6_N4_Mtase; pfam01555 401614004259 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 401614004260 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 401614004261 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 401614004262 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 401614004263 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401614004264 NAD binding site [chemical binding]; other site 401614004265 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 401614004266 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 401614004267 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 401614004268 E3 interaction surface; other site 401614004269 lipoyl attachment site [posttranslational modification]; other site 401614004270 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 401614004271 E3 interaction surface; other site 401614004272 lipoyl attachment site [posttranslational modification]; other site 401614004273 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 401614004274 E3 interaction surface; other site 401614004275 lipoyl attachment site [posttranslational modification]; other site 401614004276 e3 binding domain; Region: E3_binding; pfam02817 401614004277 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 401614004278 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 401614004279 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 401614004280 dimer interface [polypeptide binding]; other site 401614004281 TPP-binding site [chemical binding]; other site 401614004282 Uncharacterized conserved protein [Function unknown]; Region: COG1565 401614004283 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 401614004284 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 401614004285 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 401614004286 CoA-binding site [chemical binding]; other site 401614004287 ATP-binding [chemical binding]; other site 401614004288 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 401614004289 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 401614004290 active site 401614004291 HIGH motif; other site 401614004292 dimer interface [polypeptide binding]; other site 401614004293 KMSKS motif; other site 401614004294 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 401614004295 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 401614004296 Zeta toxin; Region: Zeta_toxin; pfam06414 401614004297 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 401614004298 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 401614004299 putative active site [active] 401614004300 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 401614004301 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 401614004302 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 401614004303 MutS domain I; Region: MutS_I; pfam01624 401614004304 MutS domain III; Region: MutS_III; pfam05192 401614004305 MutS domain V; Region: MutS_V; pfam00488 401614004306 Walker A/P-loop; other site 401614004307 ATP binding site [chemical binding]; other site 401614004308 Q-loop/lid; other site 401614004309 ABC transporter signature motif; other site 401614004310 Walker B; other site 401614004311 D-loop; other site 401614004312 H-loop/switch region; other site 401614004313 preprotein translocase subunit SecB; Validated; Region: PRK05751 401614004314 SecA binding site; other site 401614004315 Preprotein binding site; other site 401614004316 hypothetical protein; Provisional; Region: PRK07206 401614004317 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 401614004318 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 401614004319 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 401614004320 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 401614004321 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 401614004322 active site 401614004323 DNA binding site [nucleotide binding] 401614004324 Int/Topo IB signature motif; other site 401614004325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614004326 S-adenosylmethionine binding site [chemical binding]; other site 401614004327 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 401614004328 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 401614004329 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 401614004330 HD domain; Region: HD_4; pfam13328 401614004331 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 401614004332 synthetase active site [active] 401614004333 NTP binding site [chemical binding]; other site 401614004334 metal binding site [ion binding]; metal-binding site 401614004335 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 401614004336 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 401614004337 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 401614004338 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 401614004339 EamA-like transporter family; Region: EamA; pfam00892 401614004340 EamA-like transporter family; Region: EamA; pfam00892 401614004341 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 401614004342 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 401614004343 HSP70 interaction site [polypeptide binding]; other site 401614004344 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 401614004345 substrate binding site [polypeptide binding]; other site 401614004346 dimer interface [polypeptide binding]; other site 401614004347 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 401614004348 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 401614004349 mercuric reductase; Validated; Region: PRK06370 401614004350 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401614004351 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 401614004352 Uncharacterized conserved protein [Function unknown]; Region: COG0398 401614004353 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 401614004354 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 401614004355 DNA binding site [nucleotide binding] 401614004356 active site 401614004357 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 401614004358 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 401614004359 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 401614004360 active site 401614004361 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401614004362 substrate binding site [chemical binding]; other site 401614004363 catalytic residues [active] 401614004364 dimer interface [polypeptide binding]; other site 401614004365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 401614004366 glutamate dehydrogenase; Provisional; Region: PRK09414 401614004367 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 401614004368 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 401614004369 NAD(P) binding site [chemical binding]; other site 401614004370 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 401614004371 HI0933-like protein; Region: HI0933_like; pfam03486 401614004372 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 401614004373 short chain dehydrogenase; Validated; Region: PRK06182 401614004374 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 401614004375 NADP binding site [chemical binding]; other site 401614004376 active site 401614004377 steroid binding site; other site 401614004378 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 401614004379 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 401614004380 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 401614004381 ring oligomerisation interface [polypeptide binding]; other site 401614004382 ATP/Mg binding site [chemical binding]; other site 401614004383 stacking interactions; other site 401614004384 hinge regions; other site 401614004385 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 401614004386 oligomerisation interface [polypeptide binding]; other site 401614004387 mobile loop; other site 401614004388 roof hairpin; other site 401614004389 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 401614004390 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 401614004391 hypothetical protein; Validated; Region: PRK02101 401614004392 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 401614004393 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 401614004394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401614004395 S-adenosylmethionine binding site [chemical binding]; other site 401614004396 peptide chain release factor 1; Validated; Region: prfA; PRK00591 401614004397 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 401614004398 This domain is found in peptide chain release factors; Region: PCRF; smart00937 401614004399 RF-1 domain; Region: RF-1; pfam00472 401614004400 glutamyl-tRNA reductase; Provisional; Region: PRK13940 401614004401 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 401614004402 tRNA; other site 401614004403 putative tRNA binding site [nucleotide binding]; other site 401614004404 putative NADP binding site [chemical binding]; other site 401614004405 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 401614004406 Tetratricopeptide repeat; Region: TPR_21; pfam09976 401614004407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 401614004408 TPR motif; other site 401614004409 binding surface 401614004410 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 401614004411 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 401614004412 Trp docking motif [polypeptide binding]; other site 401614004413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004414 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 401614004415 putative substrate translocation pore; other site 401614004416 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 401614004417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401614004418 ATP binding site [chemical binding]; other site 401614004419 Mg2+ binding site [ion binding]; other site 401614004420 G-X-G motif; other site 401614004421 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 401614004422 anchoring element; other site 401614004423 dimer interface [polypeptide binding]; other site 401614004424 ATP binding site [chemical binding]; other site 401614004425 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 401614004426 active site 401614004427 metal binding site [ion binding]; metal-binding site 401614004428 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 401614004429 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 401614004430 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 401614004431 amidase catalytic site [active] 401614004432 Zn binding residues [ion binding]; other site 401614004433 substrate binding site [chemical binding]; other site 401614004434 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 401614004435 active site 401614004436 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 401614004437 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 401614004438 putative active site [active] 401614004439 Ap4A binding site [chemical binding]; other site 401614004440 nudix motif; other site 401614004441 putative metal binding site [ion binding]; other site 401614004442 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 401614004443 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 401614004444 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 401614004445 oxidoreductase, 2OG-Fe(II) oxygenase family protein; Region: PLN03002 401614004446 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 401614004447 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 401614004448 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 401614004449 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 401614004450 active site 401614004451 Int/Topo IB signature motif; other site 401614004452 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 401614004453 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 401614004454 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 401614004455 RimM N-terminal domain; Region: RimM; pfam01782 401614004456 PRC-barrel domain; Region: PRC; pfam05239 401614004457 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 401614004458 S-adenosylmethionine synthetase; Validated; Region: PRK05250 401614004459 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 401614004460 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 401614004461 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 401614004462 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 401614004463 Di-iron ligands [ion binding]; other site 401614004464 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 401614004465 UGMP family protein; Validated; Region: PRK09604 401614004466 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 401614004467 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 401614004468 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 401614004469 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 401614004470 beta and beta' interface [polypeptide binding]; other site 401614004471 beta' and sigma factor interface [polypeptide binding]; other site 401614004472 Zn-binding [ion binding]; other site 401614004473 active site region [active] 401614004474 catalytic site [active] 401614004475 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 401614004476 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 401614004477 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 401614004478 cleft; other site 401614004479 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 401614004480 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 401614004481 G-loop; other site 401614004482 DNA binding site [nucleotide binding] 401614004483 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 401614004484 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 401614004485 RPB12 interaction site [polypeptide binding]; other site 401614004486 RPB1 interaction site [polypeptide binding]; other site 401614004487 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 401614004488 RPB10 interaction site [polypeptide binding]; other site 401614004489 RPB11 interaction site [polypeptide binding]; other site 401614004490 RPB3 interaction site [polypeptide binding]; other site 401614004491 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 401614004492 core dimer interface [polypeptide binding]; other site 401614004493 peripheral dimer interface [polypeptide binding]; other site 401614004494 L10 interface [polypeptide binding]; other site 401614004495 L11 interface [polypeptide binding]; other site 401614004496 putative EF-Tu interaction site [polypeptide binding]; other site 401614004497 putative EF-G interaction site [polypeptide binding]; other site 401614004498 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 401614004499 23S rRNA interface [nucleotide binding]; other site 401614004500 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 401614004501 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 401614004502 mRNA/rRNA interface [nucleotide binding]; other site 401614004503 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 401614004504 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 401614004505 23S rRNA interface [nucleotide binding]; other site 401614004506 L7/L12 interface [polypeptide binding]; other site 401614004507 putative thiostrepton binding site; other site 401614004508 L25 interface [polypeptide binding]; other site 401614004509 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 401614004510 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 401614004511 putative homodimer interface [polypeptide binding]; other site 401614004512 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 401614004513 heterodimer interface [polypeptide binding]; other site 401614004514 homodimer interface [polypeptide binding]; other site 401614004515 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 401614004516 elongation factor Tu; Reviewed; Region: PRK00049 401614004517 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 401614004518 G1 box; other site 401614004519 GEF interaction site [polypeptide binding]; other site 401614004520 GTP/Mg2+ binding site [chemical binding]; other site 401614004521 Switch I region; other site 401614004522 G2 box; other site 401614004523 G3 box; other site 401614004524 Switch II region; other site 401614004525 G4 box; other site 401614004526 G5 box; other site 401614004527 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 401614004528 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 401614004529 Antibiotic Binding Site [chemical binding]; other site 401614004530 AAA domain; Region: AAA_30; pfam13604 401614004531 AAA domain; Region: AAA_11; pfam13086 401614004532 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 401614004533 Mechanosensitive ion channel; Region: MS_channel; pfam00924 401614004534 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 401614004535 amphipathic channel; other site 401614004536 Asn-Pro-Ala signature motifs; other site 401614004537 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 401614004538 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 401614004539 glycerol kinase; Provisional; Region: glpK; PRK00047 401614004540 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 401614004541 N- and C-terminal domain interface [polypeptide binding]; other site 401614004542 active site 401614004543 MgATP binding site [chemical binding]; other site 401614004544 catalytic site [active] 401614004545 metal binding site [ion binding]; metal-binding site 401614004546 glycerol binding site [chemical binding]; other site 401614004547 homotetramer interface [polypeptide binding]; other site 401614004548 homodimer interface [polypeptide binding]; other site 401614004549 FBP binding site [chemical binding]; other site 401614004550 protein IIAGlc interface [polypeptide binding]; other site 401614004551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004552 putative substrate translocation pore; other site 401614004553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614004554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004555 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614004556 putative substrate translocation pore; other site 401614004557 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 401614004558 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 401614004559 Walker A/P-loop; other site 401614004560 ATP binding site [chemical binding]; other site 401614004561 Q-loop/lid; other site 401614004562 ABC transporter signature motif; other site 401614004563 Walker B; other site 401614004564 D-loop; other site 401614004565 H-loop/switch region; other site 401614004566 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 401614004567 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 401614004568 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 401614004569 Walker A/P-loop; other site 401614004570 ATP binding site [chemical binding]; other site 401614004571 Q-loop/lid; other site 401614004572 ABC transporter signature motif; other site 401614004573 Walker B; other site 401614004574 D-loop; other site 401614004575 H-loop/switch region; other site 401614004576 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 401614004577 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 401614004578 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 401614004579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614004580 dimer interface [polypeptide binding]; other site 401614004581 conserved gate region; other site 401614004582 putative PBP binding loops; other site 401614004583 ABC-ATPase subunit interface; other site 401614004584 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 401614004585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401614004586 dimer interface [polypeptide binding]; other site 401614004587 conserved gate region; other site 401614004588 putative PBP binding loops; other site 401614004589 ABC-ATPase subunit interface; other site 401614004590 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 401614004591 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 401614004592 peptide binding site [polypeptide binding]; other site 401614004593 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 401614004594 Part of AAA domain; Region: AAA_19; pfam13245 401614004595 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 401614004596 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 401614004597 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 401614004598 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 401614004599 P loop; other site 401614004600 GTP binding site [chemical binding]; other site 401614004601 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 401614004602 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 401614004603 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 401614004604 G1 box; other site 401614004605 putative GEF interaction site [polypeptide binding]; other site 401614004606 GTP/Mg2+ binding site [chemical binding]; other site 401614004607 Switch I region; other site 401614004608 G2 box; other site 401614004609 G3 box; other site 401614004610 Switch II region; other site 401614004611 G4 box; other site 401614004612 G5 box; other site 401614004613 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 401614004614 thymidylate kinase; Validated; Region: tmk; PRK00698 401614004615 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 401614004616 TMP-binding site; other site 401614004617 ATP-binding site [chemical binding]; other site 401614004618 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 401614004619 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 401614004620 Nucleoside recognition; Region: Gate; pfam07670 401614004621 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 401614004622 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 401614004623 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 401614004624 Nucleoside recognition; Region: Gate; pfam07670 401614004625 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 401614004626 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 401614004627 intersubunit interface [polypeptide binding]; other site 401614004628 active site 401614004629 catalytic residue [active] 401614004630 phosphopentomutase; Provisional; Region: PRK05362 401614004631 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 401614004632 nucleotide binding site [chemical binding]; other site 401614004633 Type III pantothenate kinase; Region: Pan_kinase; cl17198 401614004634 DNA polymerase I; Provisional; Region: PRK05755 401614004635 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 401614004636 active site 401614004637 metal binding site 1 [ion binding]; metal-binding site 401614004638 putative 5' ssDNA interaction site; other site 401614004639 metal binding site 3; metal-binding site 401614004640 metal binding site 2 [ion binding]; metal-binding site 401614004641 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 401614004642 putative DNA binding site [nucleotide binding]; other site 401614004643 putative metal binding site [ion binding]; other site 401614004644 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 401614004645 active site 401614004646 catalytic site [active] 401614004647 substrate binding site [chemical binding]; other site 401614004648 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 401614004649 active site 401614004650 DNA binding site [nucleotide binding] 401614004651 catalytic site [active] 401614004652 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 401614004653 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 401614004654 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 401614004655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401614004656 Walker A/P-loop; other site 401614004657 ATP binding site [chemical binding]; other site 401614004658 Q-loop/lid; other site 401614004659 ABC transporter signature motif; other site 401614004660 Walker B; other site 401614004661 D-loop; other site 401614004662 H-loop/switch region; other site 401614004663 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 401614004664 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 401614004665 active site 401614004666 NTP binding site [chemical binding]; other site 401614004667 metal binding triad [ion binding]; metal-binding site 401614004668 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 401614004669 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 401614004670 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 401614004671 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 401614004672 HlyD family secretion protein; Region: HlyD_3; pfam13437 401614004673 multidrug efflux protein; Reviewed; Region: PRK09579 401614004674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004675 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 401614004676 putative substrate translocation pore; other site 401614004677 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 401614004678 dimer interface [polypeptide binding]; other site 401614004679 catalytic triad [active] 401614004680 ATP-grasp domain; Region: ATP-grasp_4; cl17255 401614004681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 401614004682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 401614004683 dimer interface [polypeptide binding]; other site 401614004684 phosphorylation site [posttranslational modification] 401614004685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401614004686 ATP binding site [chemical binding]; other site 401614004687 Mg2+ binding site [ion binding]; other site 401614004688 G-X-G motif; other site 401614004689 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 401614004690 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 401614004691 putative NAD(P) binding site [chemical binding]; other site 401614004692 putative active site [active] 401614004693 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 401614004694 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 401614004695 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 401614004696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 401614004697 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 401614004698 Walker A motif; other site 401614004699 ATP binding site [chemical binding]; other site 401614004700 Walker B motif; other site 401614004701 aconitate hydratase; Validated; Region: PRK09277 401614004702 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 401614004703 substrate binding site [chemical binding]; other site 401614004704 ligand binding site [chemical binding]; other site 401614004705 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 401614004706 substrate binding site [chemical binding]; other site 401614004707 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 401614004708 GtrA-like protein; Region: GtrA; pfam04138 401614004709 HemN family oxidoreductase; Provisional; Region: PRK05660 401614004710 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401614004711 FeS/SAM binding site; other site 401614004712 HemN C-terminal domain; Region: HemN_C; pfam06969 401614004713 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 401614004714 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 401614004715 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401614004716 protein translocase, SecG subunit; Region: secG; TIGR00810 401614004717 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 401614004718 substrate binding site [chemical binding]; other site 401614004719 dimer interface [polypeptide binding]; other site 401614004720 catalytic triad [active] 401614004721 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 401614004722 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 401614004723 active site 401614004724 substrate binding site [chemical binding]; other site 401614004725 metal binding site [ion binding]; metal-binding site 401614004726 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 401614004727 nucleotide binding site [chemical binding]; other site 401614004728 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401614004729 active site 401614004730 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 401614004731 E3 interaction surface; other site 401614004732 lipoyl attachment site [posttranslational modification]; other site 401614004733 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 401614004734 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 401614004735 E3 interaction surface; other site 401614004736 lipoyl attachment site [posttranslational modification]; other site 401614004737 e3 binding domain; Region: E3_binding; pfam02817 401614004738 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 401614004739 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 401614004740 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 401614004741 TPP-binding site [chemical binding]; other site 401614004742 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 401614004743 PYR/PP interface [polypeptide binding]; other site 401614004744 dimer interface [polypeptide binding]; other site 401614004745 TPP binding site [chemical binding]; other site 401614004746 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 401614004747 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 401614004748 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 401614004749 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 401614004750 L-aspartate oxidase; Provisional; Region: PRK06175 401614004751 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 401614004752 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 401614004753 SdhC subunit interface [polypeptide binding]; other site 401614004754 proximal heme binding site [chemical binding]; other site 401614004755 cardiolipin binding site; other site 401614004756 Iron-sulfur protein interface; other site 401614004757 proximal quinone binding site [chemical binding]; other site 401614004758 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 401614004759 Iron-sulfur protein interface; other site 401614004760 proximal quinone binding site [chemical binding]; other site 401614004761 SdhD (CybS) interface [polypeptide binding]; other site 401614004762 proximal heme binding site [chemical binding]; other site 401614004763 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 401614004764 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 401614004765 dimer interface [polypeptide binding]; other site 401614004766 active site 401614004767 citrylCoA binding site [chemical binding]; other site 401614004768 NADH binding [chemical binding]; other site 401614004769 cationic pore residues; other site 401614004770 oxalacetate/citrate binding site [chemical binding]; other site 401614004771 coenzyme A binding site [chemical binding]; other site 401614004772 catalytic triad [active] 401614004773 muropeptide transporter; Reviewed; Region: ampG; cl17669 401614004774 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614004775 superoxide dismutase; Provisional; Region: PRK10543 401614004776 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 401614004777 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 401614004778 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 401614004779 putative GSH binding site [chemical binding]; other site 401614004780 catalytic residues [active] 401614004781 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 401614004782 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 401614004783 putative active site [active] 401614004784 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 401614004785 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 401614004786 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 401614004787 gamma subunit interface [polypeptide binding]; other site 401614004788 epsilon subunit interface [polypeptide binding]; other site 401614004789 LBP interface [polypeptide binding]; other site 401614004790 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 401614004791 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 401614004792 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 401614004793 alpha subunit interaction interface [polypeptide binding]; other site 401614004794 Walker A motif; other site 401614004795 ATP binding site [chemical binding]; other site 401614004796 Walker B motif; other site 401614004797 inhibitor binding site; inhibition site 401614004798 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 401614004799 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 401614004800 core domain interface [polypeptide binding]; other site 401614004801 delta subunit interface [polypeptide binding]; other site 401614004802 epsilon subunit interface [polypeptide binding]; other site 401614004803 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 401614004804 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 401614004805 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 401614004806 beta subunit interaction interface [polypeptide binding]; other site 401614004807 Walker A motif; other site 401614004808 ATP binding site [chemical binding]; other site 401614004809 Walker B motif; other site 401614004810 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 401614004811 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 401614004812 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 401614004813 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 401614004814 F0F1 ATP synthase subunit C; Provisional; Region: PRK13464 401614004815 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 401614004816 ATP synthase I chain; Region: ATP_synt_I; cl09170 401614004817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004818 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614004819 putative substrate translocation pore; other site 401614004820 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 401614004821 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 401614004822 RNA binding surface [nucleotide binding]; other site 401614004823 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 401614004824 active site 401614004825 Predicted ATPase [General function prediction only]; Region: COG1485 401614004826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004827 putative substrate translocation pore; other site 401614004828 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 401614004829 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 401614004830 dimer interface [polypeptide binding]; other site 401614004831 motif 1; other site 401614004832 active site 401614004833 motif 2; other site 401614004834 motif 3; other site 401614004835 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 401614004836 anticodon binding site; other site 401614004837 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 401614004838 translation initiation factor IF-2; Validated; Region: infB; PRK05306 401614004839 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 401614004840 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 401614004841 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 401614004842 G1 box; other site 401614004843 putative GEF interaction site [polypeptide binding]; other site 401614004844 GTP/Mg2+ binding site [chemical binding]; other site 401614004845 Switch I region; other site 401614004846 G2 box; other site 401614004847 G3 box; other site 401614004848 Switch II region; other site 401614004849 G4 box; other site 401614004850 G5 box; other site 401614004851 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 401614004852 Translation-initiation factor 2; Region: IF-2; pfam11987 401614004853 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 401614004854 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 401614004855 NusA N-terminal domain; Region: NusA_N; pfam08529 401614004856 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 401614004857 RNA binding site [nucleotide binding]; other site 401614004858 homodimer interface [polypeptide binding]; other site 401614004859 NusA-like KH domain; Region: KH_5; pfam13184 401614004860 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 401614004861 G-X-X-G motif; other site 401614004862 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 401614004863 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 401614004864 hypothetical protein; Provisional; Region: PRK14641 401614004865 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 401614004866 putative oligomer interface [polypeptide binding]; other site 401614004867 putative RNA binding site [nucleotide binding]; other site 401614004868 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 401614004869 substrate binding site [chemical binding]; other site 401614004870 active site 401614004871 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 401614004872 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 401614004873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614004874 Walker A motif; other site 401614004875 ATP binding site [chemical binding]; other site 401614004876 Walker B motif; other site 401614004877 arginine finger; other site 401614004878 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 401614004879 Membrane fusogenic activity; Region: BMFP; cl01115 401614004880 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 401614004881 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 401614004882 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 401614004883 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 401614004884 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 401614004885 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 401614004886 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 401614004887 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 401614004888 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 401614004889 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 401614004890 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 401614004891 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 401614004892 NADH dehydrogenase subunit G; Validated; Region: PRK09129 401614004893 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 401614004894 catalytic loop [active] 401614004895 iron binding site [ion binding]; other site 401614004896 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 401614004897 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 401614004898 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 401614004899 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 401614004900 SLBB domain; Region: SLBB; pfam10531 401614004901 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 401614004902 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 401614004903 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 401614004904 putative dimer interface [polypeptide binding]; other site 401614004905 [2Fe-2S] cluster binding site [ion binding]; other site 401614004906 NADH dehydrogenase subunit D; Validated; Region: PRK06075 401614004907 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 401614004908 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 401614004909 NADH dehydrogenase subunit B; Validated; Region: PRK06411 401614004910 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 401614004911 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 401614004912 metal binding site 2 [ion binding]; metal-binding site 401614004913 putative DNA binding helix; other site 401614004914 metal binding site 1 [ion binding]; metal-binding site 401614004915 dimer interface [polypeptide binding]; other site 401614004916 structural Zn2+ binding site [ion binding]; other site 401614004917 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 401614004918 IucA / IucC family; Region: IucA_IucC; pfam04183 401614004919 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 401614004920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004921 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401614004922 putative substrate translocation pore; other site 401614004923 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 401614004924 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 401614004925 dimer interface [polypeptide binding]; other site 401614004926 active site 401614004927 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401614004928 catalytic residues [active] 401614004929 substrate binding site [chemical binding]; other site 401614004930 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 401614004931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004932 putative substrate translocation pore; other site 401614004933 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 401614004934 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 401614004935 active site 401614004936 catalytic triad [active] 401614004937 oxyanion hole [active] 401614004938 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 401614004939 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 401614004940 GatB domain; Region: GatB_Yqey; smart00845 401614004941 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 401614004942 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 401614004943 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 401614004944 HlyD family secretion protein; Region: HlyD_3; pfam13437 401614004945 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 401614004946 adenylosuccinate lyase; Provisional; Region: PRK07492 401614004947 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 401614004948 tetramer interface [polypeptide binding]; other site 401614004949 active site 401614004950 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 401614004951 active site 401614004952 catalytic residues [active] 401614004953 Dam-replacing family; Region: DRP; pfam06044 401614004954 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 401614004955 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 401614004956 dimerization interface [polypeptide binding]; other site 401614004957 ATP binding site [chemical binding]; other site 401614004958 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 401614004959 dimerization interface [polypeptide binding]; other site 401614004960 ATP binding site [chemical binding]; other site 401614004961 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 401614004962 putative active site [active] 401614004963 catalytic triad [active] 401614004964 amidophosphoribosyltransferase; Provisional; Region: PRK09246 401614004965 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 401614004966 active site 401614004967 tetramer interface [polypeptide binding]; other site 401614004968 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401614004969 active site 401614004970 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 401614004971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614004972 catalytic residue [active] 401614004973 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 401614004974 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 401614004975 Outer membrane efflux protein; Region: OEP; pfam02321 401614004976 Outer membrane efflux protein; Region: OEP; pfam02321 401614004977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 401614004978 putative protease; Provisional; Region: PRK15452 401614004979 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 401614004980 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 401614004981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614004982 putative substrate translocation pore; other site 401614004983 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 401614004984 Citrate transporter; Region: CitMHS; pfam03600 401614004985 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 401614004986 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 401614004987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401614004988 Walker A/P-loop; other site 401614004989 ATP binding site [chemical binding]; other site 401614004990 Q-loop/lid; other site 401614004991 ABC transporter signature motif; other site 401614004992 Walker B; other site 401614004993 D-loop; other site 401614004994 H-loop/switch region; other site 401614004995 Amino acid permease; Region: AA_permease_2; pfam13520 401614004996 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 401614004997 GTP1/OBG; Region: GTP1_OBG; pfam01018 401614004998 Obg GTPase; Region: Obg; cd01898 401614004999 G1 box; other site 401614005000 GTP/Mg2+ binding site [chemical binding]; other site 401614005001 Switch I region; other site 401614005002 G2 box; other site 401614005003 G3 box; other site 401614005004 Switch II region; other site 401614005005 G4 box; other site 401614005006 G5 box; other site 401614005007 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 401614005008 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 401614005009 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 401614005010 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 401614005011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401614005012 active site 401614005013 phosphorylation site [posttranslational modification] 401614005014 intermolecular recognition site; other site 401614005015 dimerization interface [polypeptide binding]; other site 401614005016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 401614005017 DNA binding site [nucleotide binding] 401614005018 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 401614005019 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 401614005020 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 401614005021 Ligand Binding Site [chemical binding]; other site 401614005022 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 401614005023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 401614005024 dimer interface [polypeptide binding]; other site 401614005025 phosphorylation site [posttranslational modification] 401614005026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401614005027 ATP binding site [chemical binding]; other site 401614005028 Mg2+ binding site [ion binding]; other site 401614005029 G-X-G motif; other site 401614005030 K+-transporting ATPase, c chain; Region: KdpC; cl00944 401614005031 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 401614005032 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 401614005033 Soluble P-type ATPase [General function prediction only]; Region: COG4087 401614005034 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 401614005035 formate dehydrogenase; Provisional; Region: PRK07574 401614005036 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 401614005037 dimerization interface [polypeptide binding]; other site 401614005038 ligand binding site [chemical binding]; other site 401614005039 NAD binding site [chemical binding]; other site 401614005040 catalytic site [active] 401614005041 aspartate aminotransferase; Provisional; Region: PRK05764 401614005042 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401614005043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614005044 homodimer interface [polypeptide binding]; other site 401614005045 catalytic residue [active] 401614005046 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 401614005047 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810 401614005048 active site 401614005049 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401614005050 dimer interface [polypeptide binding]; other site 401614005051 catalytic residues [active] 401614005052 substrate binding site [chemical binding]; other site 401614005053 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 401614005054 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 401614005055 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 401614005056 trimer interface [polypeptide binding]; other site 401614005057 active site 401614005058 substrate binding site [chemical binding]; other site 401614005059 CoA binding site [chemical binding]; other site 401614005060 dihydrodipicolinate synthase; Provisional; Region: PRK03170 401614005061 catalytic residue [active] 401614005062 dihydrodipicolinate reductase; Provisional; Region: PRK00048 401614005063 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 401614005064 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 401614005065 aspartate kinase III; Validated; Region: PRK09084 401614005066 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 401614005067 nucleotide binding site [chemical binding]; other site 401614005068 substrate binding site [chemical binding]; other site 401614005069 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 401614005070 lysine allosteric regulatory site; other site 401614005071 dimer interface [polypeptide binding]; other site 401614005072 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 401614005073 Putative lysophospholipase; Region: Hydrolase_4; cl19140 401614005074 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 401614005075 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 401614005076 active site 401614005077 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 401614005078 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 401614005079 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 401614005080 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 401614005081 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 401614005082 Cl- selectivity filter; other site 401614005083 Cl- binding residues [ion binding]; other site 401614005084 pore gating glutamate residue; other site 401614005085 dimer interface [polypeptide binding]; other site 401614005086 H+/Cl- coupling transport residue; other site 401614005087 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 401614005088 active site 401614005089 Zn binding site [ion binding]; other site 401614005090 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 401614005091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401614005092 catalytic residue [active] 401614005093 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 401614005094 substrate binding site [chemical binding]; other site 401614005095 active site 401614005096 catalytic residues [active] 401614005097 heterodimer interface [polypeptide binding]; other site 401614005098 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 401614005099 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 401614005100 Clp amino terminal domain; Region: Clp_N; pfam02861 401614005101 Clp amino terminal domain; Region: Clp_N; pfam02861 401614005102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614005103 Walker A motif; other site 401614005104 ATP binding site [chemical binding]; other site 401614005105 Walker B motif; other site 401614005106 arginine finger; other site 401614005107 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 401614005108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401614005109 Walker A motif; other site 401614005110 ATP binding site [chemical binding]; other site 401614005111 Walker B motif; other site 401614005112 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 401614005113 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 401614005114 aromatic chitin/cellulose binding site residues [chemical binding]; other site 401614005115 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 401614005116 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 401614005117 active site 401614005118 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 401614005119 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 401614005120 ATP-grasp domain; Region: ATP-grasp; pfam02222 401614005121 Frag1/DRAM/Sfk1 family; Region: Frag1; pfam10277 401614005122 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 401614005123 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 401614005124 4Fe-4S binding domain; Region: Fer4; pfam00037 401614005125 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 401614005126 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 401614005127 putative acyl-acceptor binding pocket; other site 401614005128 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 401614005129 putative acyl-acceptor binding pocket; other site 401614005130 hypothetical protein; Provisional; Region: PRK05421 401614005131 putative catalytic site [active] 401614005132 putative metal binding site [ion binding]; other site 401614005133 putative phosphate binding site [ion binding]; other site 401614005134 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854 401614005135 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 401614005136 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 401614005137 [2Fe-2S] cluster binding site [ion binding]; other site 401614005138 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 401614005139 hydrophobic ligand binding site; other site 401614005140 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 401614005141 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614005142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614005143 putative substrate translocation pore; other site 401614005144 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 401614005145 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 401614005146 catalytic triad [active] 401614005147 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 401614005148 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 401614005149 putative ligand binding site [chemical binding]; other site 401614005150 putative NAD binding site [chemical binding]; other site 401614005151 catalytic site [active] 401614005152 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 401614005153 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 401614005154 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 401614005155 putative NAD(P) binding site [chemical binding]; other site 401614005156 substrate binding site [chemical binding]; other site 401614005157 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 401614005158 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 401614005159 ABC transporter; Region: ABC_tran_2; pfam12848 401614005160 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 401614005161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401614005162 metabolite-proton symporter; Region: 2A0106; TIGR00883 401614005163 putative substrate translocation pore; other site 401614005164 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 401614005165 Ureide permease; Region: Ureide_permease; pfam07168 401614005166 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 401614005167 substrate binding site [chemical binding]; other site 401614005168 dimer interface [polypeptide binding]; other site 401614005169 ATP binding site [chemical binding]; other site 401614005170 aminopeptidase N; Provisional; Region: pepN; PRK14015 401614005171 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 401614005172 active site 401614005173 Zn binding site [ion binding]; other site 401614005174 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 401614005175 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 401614005176 putative dimer interface [polypeptide binding]; other site 401614005177 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 401614005178 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 401614005179 active site 401614005180 ribulose/triose binding site [chemical binding]; other site 401614005181 phosphate binding site [ion binding]; other site 401614005182 substrate (anthranilate) binding pocket [chemical binding]; other site 401614005183 product (indole) binding pocket [chemical binding]; other site 401614005184 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 401614005185 active site 401614005186 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 401614005187 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 401614005188 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 401614005189 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 401614005190 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 401614005191 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 401614005192 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 401614005193 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 401614005194 Glutamine amidotransferase class-I; Region: GATase; pfam00117 401614005195 glutamine binding [chemical binding]; other site 401614005196 catalytic triad [active] 401614005197 anthranilate synthase component I; Provisional; Region: PRK13564 401614005198 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 401614005199 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 401614005200 Trp repressor protein; Region: Trp_repressor; cl17266 401614005201 ribonuclease G; Provisional; Region: PRK11712 401614005202 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 401614005203 homodimer interface [polypeptide binding]; other site 401614005204 oligonucleotide binding site [chemical binding]; other site 401614005205 Ribonuclease E/G family; Region: RNase_E_G; pfam10150