-- dump date 20140619_095039 -- class Genbank::misc_feature -- table misc_feature_note -- id note 484022000001 Replication protein; Region: Rep_1; cl02412 484022000002 shikimate kinase; Reviewed; Region: aroK; PRK00131 484022000003 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 484022000004 ADP binding site [chemical binding]; other site 484022000005 magnesium binding site [ion binding]; other site 484022000006 putative shikimate binding site; other site 484022000007 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 484022000008 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 484022000009 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 484022000010 Pilus assembly protein, PilP; Region: PilP; pfam04351 484022000011 Pilus assembly protein, PilO; Region: PilO; cl01234 484022000012 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 484022000013 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 484022000014 adenylate kinase; Reviewed; Region: adk; PRK00279 484022000015 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 484022000016 AMP-binding site [chemical binding]; other site 484022000017 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 484022000018 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 484022000019 FAD binding domain; Region: FAD_binding_4; pfam01565 484022000020 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 484022000021 Cysteine-rich domain; Region: CCG; pfam02754 484022000022 GTPase Era; Reviewed; Region: era; PRK00089 484022000023 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 484022000024 G1 box; other site 484022000025 GTP/Mg2+ binding site [chemical binding]; other site 484022000026 Switch I region; other site 484022000027 G2 box; other site 484022000028 Switch II region; other site 484022000029 G3 box; other site 484022000030 G4 box; other site 484022000031 G5 box; other site 484022000032 KH domain; Region: KH_2; pfam07650 484022000033 aspartate aminotransferase; Provisional; Region: PRK05764 484022000034 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484022000035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022000036 homodimer interface [polypeptide binding]; other site 484022000037 catalytic residue [active] 484022000038 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 484022000039 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 484022000040 putative active site [active] 484022000041 putative dimer interface [polypeptide binding]; other site 484022000042 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 484022000043 Glycoprotease family; Region: Peptidase_M22; pfam00814 484022000044 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 484022000045 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 484022000046 active site 484022000047 dimer interface [polypeptide binding]; other site 484022000048 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 484022000049 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 484022000050 GTP/Mg2+ binding site [chemical binding]; other site 484022000051 G4 box; other site 484022000052 G5 box; other site 484022000053 G1 box; other site 484022000054 Switch I region; other site 484022000055 G2 box; other site 484022000056 G3 box; other site 484022000057 Switch II region; other site 484022000058 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 484022000059 Sel1-like repeats; Region: SEL1; smart00671 484022000060 Sel1-like repeats; Region: SEL1; smart00671 484022000061 thymidine kinase; Provisional; Region: PRK04296 484022000062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 484022000063 Methyltransferase domain; Region: Methyltransf_31; pfam13847 484022000064 S-adenosylmethionine binding site [chemical binding]; other site 484022000065 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 484022000066 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 484022000067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484022000068 FeS/SAM binding site; other site 484022000069 TRAM domain; Region: TRAM; pfam01938 484022000070 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 484022000071 PhoH-like protein; Region: PhoH; pfam02562 484022000072 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 484022000073 FOG: CBS domain [General function prediction only]; Region: COG0517 484022000074 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 484022000075 Transporter associated domain; Region: CorC_HlyC; smart01091 484022000076 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 484022000077 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 484022000078 putative active site [active] 484022000079 catalytic triad [active] 484022000080 putative dimer interface [polypeptide binding]; other site 484022000081 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 484022000082 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 484022000083 beta-lactamase TEM; Provisional; Region: PRK15442 484022000084 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 484022000085 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 484022000086 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 484022000087 active site 484022000088 substrate binding site [chemical binding]; other site 484022000089 Mg2+ binding site [ion binding]; other site 484022000090 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 484022000091 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 484022000092 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 484022000093 active site 484022000094 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 484022000095 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 484022000096 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 484022000097 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 484022000098 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 484022000099 Uncharacterized conserved protein [Function unknown]; Region: COG0327 484022000100 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 484022000101 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 484022000102 active site 484022000103 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 484022000104 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 484022000105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000106 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 484022000107 putative substrate translocation pore; other site 484022000108 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 484022000109 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 484022000110 dimer interface [polypeptide binding]; other site 484022000111 active site 484022000112 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 484022000113 dimer interface [polypeptide binding]; other site 484022000114 active site 484022000115 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 484022000116 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 484022000117 Uncharacterized conserved protein [Function unknown]; Region: COG0397 484022000118 hypothetical protein; Validated; Region: PRK00029 484022000119 Rubredoxin [Energy production and conversion]; Region: COG1773 484022000120 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 484022000121 iron binding site [ion binding]; other site 484022000122 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 484022000123 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 484022000124 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022000125 catalytic residue [active] 484022000126 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000127 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022000128 Integrase core domain; Region: rve; pfam00665 484022000129 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 484022000130 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 484022000131 G1 box; other site 484022000132 putative GEF interaction site [polypeptide binding]; other site 484022000133 GTP/Mg2+ binding site [chemical binding]; other site 484022000134 Switch I region; other site 484022000135 G2 box; other site 484022000136 G3 box; other site 484022000137 Switch II region; other site 484022000138 G4 box; other site 484022000139 G5 box; other site 484022000140 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 484022000141 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 484022000142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022000143 short chain dehydrogenase; Validated; Region: PRK07069 484022000144 NAD(P) binding site [chemical binding]; other site 484022000145 active site 484022000146 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 484022000147 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 484022000148 VacJ like lipoprotein; Region: VacJ; cl01073 484022000149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 484022000150 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 484022000151 Transposase IS200 like; Region: Y1_Tnp; cl00848 484022000152 hypothetical protein; Validated; Region: PRK01777 484022000153 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 484022000154 putative coenzyme Q binding site [chemical binding]; other site 484022000155 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 484022000156 SmpB-tmRNA interface; other site 484022000157 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 484022000158 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 484022000159 Ligand Binding Site [chemical binding]; other site 484022000160 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000161 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022000162 Integrase core domain; Region: rve; pfam00665 484022000163 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 484022000164 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000165 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022000166 Integrase core domain; Region: rve; pfam00665 484022000167 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 484022000168 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 484022000169 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 484022000170 metal binding site [ion binding]; metal-binding site 484022000171 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 484022000172 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 484022000173 substrate binding site [chemical binding]; other site 484022000174 glutamase interaction surface [polypeptide binding]; other site 484022000175 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 484022000176 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 484022000177 catalytic residues [active] 484022000178 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 484022000179 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 484022000180 putative active site [active] 484022000181 oxyanion strand; other site 484022000182 catalytic triad [active] 484022000183 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 484022000184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484022000185 active site 484022000186 motif I; other site 484022000187 motif II; other site 484022000188 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 484022000189 putative active site pocket [active] 484022000190 4-fold oligomerization interface [polypeptide binding]; other site 484022000191 metal binding residues [ion binding]; metal-binding site 484022000192 3-fold/trimer interface [polypeptide binding]; other site 484022000193 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 484022000194 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484022000195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022000196 homodimer interface [polypeptide binding]; other site 484022000197 catalytic residue [active] 484022000198 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 484022000199 histidinol dehydrogenase; Region: hisD; TIGR00069 484022000200 NAD binding site [chemical binding]; other site 484022000201 dimerization interface [polypeptide binding]; other site 484022000202 product binding site; other site 484022000203 substrate binding site [chemical binding]; other site 484022000204 zinc binding site [ion binding]; other site 484022000205 catalytic residues [active] 484022000206 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 484022000207 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 484022000208 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 484022000209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000210 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022000211 putative substrate translocation pore; other site 484022000212 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 484022000213 putative active site [active] 484022000214 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 484022000215 putative active site [active] 484022000216 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 484022000217 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 484022000218 generic binding surface II; other site 484022000219 generic binding surface I; other site 484022000220 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 484022000221 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 484022000222 metal binding site [ion binding]; metal-binding site 484022000223 dimer interface [polypeptide binding]; other site 484022000224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484022000225 Coenzyme A binding pocket [chemical binding]; other site 484022000226 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 484022000227 putative dimer interface [polypeptide binding]; other site 484022000228 putative active site [active] 484022000229 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 484022000230 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 484022000231 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 484022000232 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 484022000233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 484022000234 Uncharacterized conserved protein [Function unknown]; Region: COG2308 484022000235 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022000236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000237 putative substrate translocation pore; other site 484022000238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000239 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022000240 putative substrate translocation pore; other site 484022000241 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000242 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022000243 Integrase core domain; Region: rve; pfam00665 484022000244 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 484022000245 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 484022000246 ATP binding site [chemical binding]; other site 484022000247 substrate interface [chemical binding]; other site 484022000248 HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898 484022000249 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 484022000250 substrate binding site [chemical binding]; other site 484022000251 dimer interface [polypeptide binding]; other site 484022000252 ATP binding site [chemical binding]; other site 484022000253 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 484022000254 thiamine phosphate binding site [chemical binding]; other site 484022000255 active site 484022000256 pyrophosphate binding site [ion binding]; other site 484022000257 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 484022000258 ThiS interaction site; other site 484022000259 putative active site [active] 484022000260 tetramer interface [polypeptide binding]; other site 484022000261 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 484022000262 thiS-thiF/thiG interaction site; other site 484022000263 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 484022000264 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 484022000265 ThiC-associated domain; Region: ThiC-associated; pfam13667 484022000266 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 484022000267 glutamate racemase; Provisional; Region: PRK00865 484022000268 Nuclease-related domain; Region: NERD; pfam08378 484022000269 excinuclease ABC subunit B; Provisional; Region: PRK05298 484022000270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022000271 ATP binding site [chemical binding]; other site 484022000272 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022000273 nucleotide binding region [chemical binding]; other site 484022000274 ATP-binding site [chemical binding]; other site 484022000275 Ultra-violet resistance protein B; Region: UvrB; pfam12344 484022000276 UvrB/uvrC motif; Region: UVR; pfam02151 484022000277 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 484022000278 active site 484022000279 catalytic site [active] 484022000280 substrate binding site [chemical binding]; other site 484022000281 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 484022000282 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 484022000283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022000284 NAD(P) binding site [chemical binding]; other site 484022000285 active site 484022000286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484022000287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484022000288 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 484022000289 putative effector binding pocket; other site 484022000290 dimerization interface [polypeptide binding]; other site 484022000291 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 484022000292 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 484022000293 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 484022000294 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 484022000295 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 484022000296 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484022000297 active site 484022000298 dimer interface [polypeptide binding]; other site 484022000299 Pirin-related protein [General function prediction only]; Region: COG1741 484022000300 Pirin; Region: Pirin; pfam02678 484022000301 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 484022000302 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 484022000303 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 484022000304 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022000305 catalytic residue [active] 484022000306 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 484022000307 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 484022000308 23S rRNA binding site [nucleotide binding]; other site 484022000309 L21 binding site [polypeptide binding]; other site 484022000310 L13 binding site [polypeptide binding]; other site 484022000311 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 484022000312 translation initiation factor IF-3; Region: infC; TIGR00168 484022000313 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 484022000314 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 484022000315 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 484022000316 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 484022000317 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 484022000318 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 484022000319 active site 484022000320 dimer interface [polypeptide binding]; other site 484022000321 motif 1; other site 484022000322 motif 2; other site 484022000323 motif 3; other site 484022000324 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 484022000325 anticodon binding site; other site 484022000326 Chitin binding domain; Region: Chitin_bind_3; pfam03067 484022000327 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 484022000328 aromatic chitin/cellulose binding site residues [chemical binding]; other site 484022000329 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 484022000330 lipoyl attachment site [posttranslational modification]; other site 484022000331 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 484022000332 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 484022000333 homodimer interface [polypeptide binding]; other site 484022000334 active site 484022000335 hypothetical protein; Validated; Region: PRK00153 484022000336 recombination protein RecR; Provisional; Region: PRK13844 484022000337 RecR protein; Region: RecR; pfam02132 484022000338 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 484022000339 putative active site [active] 484022000340 putative metal-binding site [ion binding]; other site 484022000341 tetramer interface [polypeptide binding]; other site 484022000342 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 484022000343 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 484022000344 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 484022000345 Walker A motif; other site 484022000346 ATP binding site [chemical binding]; other site 484022000347 Walker B motif; other site 484022000348 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 484022000349 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 484022000350 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 484022000351 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000352 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022000353 Integrase core domain; Region: rve; pfam00665 484022000354 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 484022000355 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 484022000356 ligand binding site [chemical binding]; other site 484022000357 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 484022000358 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 484022000359 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 484022000360 active site 484022000361 (T/H)XGH motif; other site 484022000362 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 484022000363 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 484022000364 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 484022000365 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 484022000366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022000367 catalytic residue [active] 484022000368 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 484022000369 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 484022000370 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 484022000371 Protein of unknown function DUF45; Region: DUF45; pfam01863 484022000372 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 484022000373 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 484022000374 active site 484022000375 metal binding site [ion binding]; metal-binding site 484022000376 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 484022000377 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 484022000378 Prephenate dehydratase; Region: PDT; pfam00800 484022000379 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 484022000380 putative L-Phe binding site [chemical binding]; other site 484022000381 amino acid transporter; Region: 2A0306; TIGR00909 484022000382 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 484022000383 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 484022000384 active site 484022000385 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484022000386 dimer interface [polypeptide binding]; other site 484022000387 substrate binding site [chemical binding]; other site 484022000388 catalytic residues [active] 484022000389 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 484022000390 POT family; Region: PTR2; cl17359 484022000391 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 484022000392 putative C-terminal domain interface [polypeptide binding]; other site 484022000393 putative GSH binding site [chemical binding]; other site 484022000394 putative dimer interface [polypeptide binding]; other site 484022000395 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 484022000396 dimer interface [polypeptide binding]; other site 484022000397 substrate binding pocket (H-site) [chemical binding]; other site 484022000398 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 484022000399 putative N-terminal domain interface [polypeptide binding]; other site 484022000400 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 484022000401 hypothetical protein; Provisional; Region: PRK14013 484022000402 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 484022000403 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 484022000404 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 484022000405 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000406 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022000407 Integrase core domain; Region: rve; pfam00665 484022000408 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 484022000409 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000410 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022000411 Integrase core domain; Region: rve; pfam00665 484022000412 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 484022000413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484022000414 Walker A/P-loop; other site 484022000415 ATP binding site [chemical binding]; other site 484022000416 Q-loop/lid; other site 484022000417 ABC transporter signature motif; other site 484022000418 Walker B; other site 484022000419 D-loop; other site 484022000420 H-loop/switch region; other site 484022000421 TOBE domain; Region: TOBE_2; pfam08402 484022000422 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 484022000423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484022000424 dimer interface [polypeptide binding]; other site 484022000425 conserved gate region; other site 484022000426 putative PBP binding loops; other site 484022000427 ABC-ATPase subunit interface; other site 484022000428 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 484022000429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484022000430 dimer interface [polypeptide binding]; other site 484022000431 conserved gate region; other site 484022000432 putative PBP binding loops; other site 484022000433 ABC-ATPase subunit interface; other site 484022000434 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 484022000435 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 484022000436 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 484022000437 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 484022000438 Uncharacterized conserved protein [Function unknown]; Region: COG2128 484022000439 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 484022000440 DEAD/DEAH box helicase; Region: DEAD; pfam00270 484022000441 ATP binding site [chemical binding]; other site 484022000442 putative Mg++ binding site [ion binding]; other site 484022000443 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 484022000444 SEC-C motif; Region: SEC-C; pfam02810 484022000445 LPP20 lipoprotein; Region: LPP20; pfam02169 484022000446 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 484022000447 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 484022000448 FtsH Extracellular; Region: FtsH_ext; pfam06480 484022000449 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 484022000450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484022000451 Walker A motif; other site 484022000452 ATP binding site [chemical binding]; other site 484022000453 Walker B motif; other site 484022000454 arginine finger; other site 484022000455 Peptidase family M41; Region: Peptidase_M41; pfam01434 484022000456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000457 putative substrate translocation pore; other site 484022000458 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 484022000459 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 484022000460 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 484022000461 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 484022000462 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 484022000463 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 484022000464 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 484022000465 Type II transport protein GspH; Region: GspH; pfam12019 484022000466 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 484022000467 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 484022000468 active site 484022000469 dimer interface [polypeptide binding]; other site 484022000470 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 484022000471 dimer interface [polypeptide binding]; other site 484022000472 active site 484022000473 Thiamine pyrophosphokinase; Region: TPK; cd07995 484022000474 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 484022000475 active site 484022000476 dimerization interface [polypeptide binding]; other site 484022000477 thiamine binding site [chemical binding]; other site 484022000478 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 484022000479 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 484022000480 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 484022000481 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 484022000482 active site 484022000483 multifunctional aminopeptidase A; Provisional; Region: PRK00913 484022000484 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 484022000485 interface (dimer of trimers) [polypeptide binding]; other site 484022000486 Substrate-binding/catalytic site; other site 484022000487 Zn-binding sites [ion binding]; other site 484022000488 Predicted permeases [General function prediction only]; Region: COG0795 484022000489 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 484022000490 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 484022000491 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 484022000492 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 484022000493 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 484022000494 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 484022000495 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 484022000496 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 484022000497 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 484022000498 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 484022000499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022000500 S-adenosylmethionine binding site [chemical binding]; other site 484022000501 Predicted membrane protein [Function unknown]; Region: COG2860 484022000502 UPF0126 domain; Region: UPF0126; pfam03458 484022000503 UPF0126 domain; Region: UPF0126; pfam03458 484022000504 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 484022000505 active site 484022000506 dinuclear metal binding site [ion binding]; other site 484022000507 dimerization interface [polypeptide binding]; other site 484022000508 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 484022000509 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 484022000510 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 484022000511 active site 484022000512 catalytic motif [active] 484022000513 Zn binding site [ion binding]; other site 484022000514 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 484022000515 FAD binding domain; Region: FAD_binding_4; pfam01565 484022000516 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 484022000517 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 484022000518 phosphoglyceromutase; Provisional; Region: PRK05434 484022000519 seryl-tRNA synthetase; Provisional; Region: PRK05431 484022000520 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 484022000521 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 484022000522 dimer interface [polypeptide binding]; other site 484022000523 active site 484022000524 motif 1; other site 484022000525 motif 2; other site 484022000526 motif 3; other site 484022000527 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484022000528 ROK family; Region: ROK; pfam00480 484022000529 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 484022000530 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 484022000531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484022000532 Walker A/P-loop; other site 484022000533 ATP binding site [chemical binding]; other site 484022000534 Q-loop/lid; other site 484022000535 ABC transporter signature motif; other site 484022000536 Walker B; other site 484022000537 D-loop; other site 484022000538 H-loop/switch region; other site 484022000539 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 484022000540 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484022000541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484022000542 Walker A/P-loop; other site 484022000543 ATP binding site [chemical binding]; other site 484022000544 Q-loop/lid; other site 484022000545 ABC transporter signature motif; other site 484022000546 Walker B; other site 484022000547 D-loop; other site 484022000548 H-loop/switch region; other site 484022000549 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000550 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022000551 Integrase core domain; Region: rve; pfam00665 484022000552 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 484022000553 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 484022000554 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000555 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022000556 Integrase core domain; Region: rve; pfam00665 484022000557 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 484022000558 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 484022000559 HsdM N-terminal domain; Region: HsdM_N; pfam12161 484022000560 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 484022000561 Methyltransferase domain; Region: Methyltransf_26; pfam13659 484022000562 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 484022000563 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 484022000564 MAPEG family; Region: MAPEG; pfam01124 484022000565 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 484022000566 homotrimer interaction site [polypeptide binding]; other site 484022000567 putative active site [active] 484022000568 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 484022000569 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 484022000570 Sulfate transporter family; Region: Sulfate_transp; pfam00916 484022000571 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 484022000572 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 484022000573 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 484022000574 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 484022000575 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000576 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022000577 Integrase core domain; Region: rve; pfam00665 484022000578 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 484022000579 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 484022000580 Walker A/P-loop; other site 484022000581 ATP binding site [chemical binding]; other site 484022000582 Q-loop/lid; other site 484022000583 ABC transporter signature motif; other site 484022000584 Walker B; other site 484022000585 D-loop; other site 484022000586 H-loop/switch region; other site 484022000587 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 484022000588 HlyD family secretion protein; Region: HlyD_3; pfam13437 484022000589 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 484022000590 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 484022000591 active site 484022000592 catalytic site [active] 484022000593 metal binding site [ion binding]; metal-binding site 484022000594 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 484022000595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000596 putative substrate translocation pore; other site 484022000597 classical (c) SDRs; Region: SDR_c; cd05233 484022000598 NAD(P) binding site [chemical binding]; other site 484022000599 active site 484022000600 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 484022000601 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 484022000602 heme binding site [chemical binding]; other site 484022000603 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 484022000604 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 484022000605 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484022000606 Zn2+ binding site [ion binding]; other site 484022000607 Mg2+ binding site [ion binding]; other site 484022000608 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 484022000609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000610 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022000611 putative substrate translocation pore; other site 484022000612 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 484022000613 putative substrate binding pocket [chemical binding]; other site 484022000614 trimer interface [polypeptide binding]; other site 484022000615 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 484022000616 putative efflux protein, MATE family; Region: matE; TIGR00797 484022000617 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 484022000618 aromatic chitin/cellulose binding site residues [chemical binding]; other site 484022000619 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 484022000620 active site 484022000621 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 484022000622 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 484022000623 aromatic chitin/cellulose binding site residues [chemical binding]; other site 484022000624 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 484022000625 active site 484022000626 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000627 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022000628 Integrase core domain; Region: rve; pfam00665 484022000629 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 484022000630 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 484022000631 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 484022000632 putative active site [active] 484022000633 putative substrate binding site [chemical binding]; other site 484022000634 putative cosubstrate binding site; other site 484022000635 catalytic site [active] 484022000636 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484022000637 active site 484022000638 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 484022000639 Glyco_18 domain; Region: Glyco_18; smart00636 484022000640 active site 484022000641 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 484022000642 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 484022000643 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 484022000644 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 484022000645 aromatic chitin/cellulose binding site residues [chemical binding]; other site 484022000646 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 484022000647 aromatic chitin/cellulose binding site residues [chemical binding]; other site 484022000648 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 484022000649 aromatic chitin/cellulose binding site residues [chemical binding]; other site 484022000650 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 484022000651 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 484022000652 substrate-cofactor binding pocket; other site 484022000653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022000654 catalytic residue [active] 484022000655 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 484022000656 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 484022000657 NAD(P) binding site [chemical binding]; other site 484022000658 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 484022000659 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 484022000660 substrate binding site; other site 484022000661 dimer interface; other site 484022000662 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 484022000663 Septum formation initiator; Region: DivIC; cl17659 484022000664 enolase; Provisional; Region: eno; PRK00077 484022000665 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 484022000666 dimer interface [polypeptide binding]; other site 484022000667 metal binding site [ion binding]; metal-binding site 484022000668 substrate binding pocket [chemical binding]; other site 484022000669 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022000670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000671 putative substrate translocation pore; other site 484022000672 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 484022000673 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484022000674 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484022000675 nucleotide binding site [chemical binding]; other site 484022000676 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484022000677 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484022000678 nucleotide binding site [chemical binding]; other site 484022000679 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 484022000680 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 484022000681 TRAM domain; Region: TRAM; pfam01938 484022000682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022000683 S-adenosylmethionine binding site [chemical binding]; other site 484022000684 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 484022000685 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 484022000686 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 484022000687 ATP-binding site [chemical binding]; other site 484022000688 Sugar specificity; other site 484022000689 Pyrimidine base specificity; other site 484022000690 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 484022000691 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 484022000692 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 484022000693 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 484022000694 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 484022000695 oligomer interface [polypeptide binding]; other site 484022000696 RNA binding site [nucleotide binding]; other site 484022000697 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 484022000698 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 484022000699 RNase E interface [polypeptide binding]; other site 484022000700 trimer interface [polypeptide binding]; other site 484022000701 active site 484022000702 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 484022000703 putative nucleic acid binding region [nucleotide binding]; other site 484022000704 G-X-X-G motif; other site 484022000705 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 484022000706 RNA binding site [nucleotide binding]; other site 484022000707 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 484022000708 16S/18S rRNA binding site [nucleotide binding]; other site 484022000709 S13e-L30e interaction site [polypeptide binding]; other site 484022000710 25S rRNA binding site [nucleotide binding]; other site 484022000711 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 484022000712 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 484022000713 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 484022000714 Cell division protein FtsL; Region: FtsL; cl11433 484022000715 MraW methylase family; Region: Methyltransf_5; cl17771 484022000716 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 484022000717 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 484022000718 AMP-binding enzyme; Region: AMP-binding; pfam00501 484022000719 acyl-activating enzyme (AAE) consensus motif; other site 484022000720 putative AMP binding site [chemical binding]; other site 484022000721 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 484022000722 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 484022000723 DNA binding site [nucleotide binding] 484022000724 catalytic residue [active] 484022000725 H2TH interface [polypeptide binding]; other site 484022000726 putative catalytic residues [active] 484022000727 turnover-facilitating residue; other site 484022000728 intercalation triad [nucleotide binding]; other site 484022000729 8OG recognition residue [nucleotide binding]; other site 484022000730 putative reading head residues; other site 484022000731 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 484022000732 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 484022000733 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 484022000734 predicted active site [active] 484022000735 catalytic triad [active] 484022000736 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 484022000737 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 484022000738 active site 484022000739 multimer interface [polypeptide binding]; other site 484022000740 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 484022000741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484022000742 ATP binding site [chemical binding]; other site 484022000743 Mg2+ binding site [ion binding]; other site 484022000744 G-X-G motif; other site 484022000745 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 484022000746 anchoring element; other site 484022000747 dimer interface [polypeptide binding]; other site 484022000748 ATP binding site [chemical binding]; other site 484022000749 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 484022000750 active site 484022000751 putative metal-binding site [ion binding]; other site 484022000752 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 484022000753 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 484022000754 putative active site pocket [active] 484022000755 dimerization interface [polypeptide binding]; other site 484022000756 putative catalytic residue [active] 484022000757 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 484022000758 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 484022000759 FMN binding site [chemical binding]; other site 484022000760 active site 484022000761 catalytic residues [active] 484022000762 substrate binding site [chemical binding]; other site 484022000763 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484022000764 TIGR03546 family protein; Region: TIGR03546 484022000765 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 484022000766 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 484022000767 CoA-ligase; Region: Ligase_CoA; pfam00549 484022000768 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 484022000769 CoA binding domain; Region: CoA_binding; smart00881 484022000770 CoA-ligase; Region: Ligase_CoA; pfam00549 484022000771 Cytochrome P450; Region: p450; cl12078 484022000772 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 484022000773 C factor cell-cell signaling protein; Provisional; Region: PRK09009 484022000774 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 484022000775 NADP binding site [chemical binding]; other site 484022000776 homodimer interface [polypeptide binding]; other site 484022000777 active site 484022000778 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 484022000779 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 484022000780 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 484022000781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000782 putative substrate translocation pore; other site 484022000783 POT family; Region: PTR2; cl17359 484022000784 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 484022000785 active site 484022000786 dimer interface [polypeptide binding]; other site 484022000787 catalytic nucleophile [active] 484022000788 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 484022000789 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 484022000790 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 484022000791 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 484022000792 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 484022000793 phosphoglycolate phosphatase; Provisional; Region: PRK13222 484022000794 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 484022000795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484022000796 motif II; other site 484022000797 thioredoxin reductase; Provisional; Region: PRK10262 484022000798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484022000799 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484022000800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000801 putative substrate translocation pore; other site 484022000802 H+ Antiporter protein; Region: 2A0121; TIGR00900 484022000803 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 484022000804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484022000805 ATP binding site [chemical binding]; other site 484022000806 Mg2+ binding site [ion binding]; other site 484022000807 G-X-G motif; other site 484022000808 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 484022000809 ATP binding site [chemical binding]; other site 484022000810 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 484022000811 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 484022000812 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 484022000813 GTPase RsgA; Reviewed; Region: PRK00098 484022000814 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 484022000815 RNA binding site [nucleotide binding]; other site 484022000816 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 484022000817 GTPase/Zn-binding domain interface [polypeptide binding]; other site 484022000818 GTP/Mg2+ binding site [chemical binding]; other site 484022000819 G4 box; other site 484022000820 G5 box; other site 484022000821 G1 box; other site 484022000822 Switch I region; other site 484022000823 G2 box; other site 484022000824 G3 box; other site 484022000825 Switch II region; other site 484022000826 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 484022000827 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 484022000828 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 484022000829 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 484022000830 Domain of unknown function DUF20; Region: UPF0118; pfam01594 484022000831 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 484022000832 DHH family; Region: DHH; pfam01368 484022000833 DHHA1 domain; Region: DHHA1; pfam02272 484022000834 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 484022000835 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 484022000836 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 484022000837 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 484022000838 motif 1; other site 484022000839 dimer interface [polypeptide binding]; other site 484022000840 active site 484022000841 motif 2; other site 484022000842 motif 3; other site 484022000843 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 484022000844 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484022000845 Helix-turn-helix domain; Region: HTH_25; pfam13413 484022000846 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 484022000847 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 484022000848 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 484022000849 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 484022000850 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 484022000851 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 484022000852 carboxyltransferase (CT) interaction site; other site 484022000853 biotinylation site [posttranslational modification]; other site 484022000854 Dehydroquinase class II; Region: DHquinase_II; pfam01220 484022000855 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 484022000856 trimer interface [polypeptide binding]; other site 484022000857 active site 484022000858 dimer interface [polypeptide binding]; other site 484022000859 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 484022000860 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 484022000861 active site 484022000862 metal binding site [ion binding]; metal-binding site 484022000863 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 484022000864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022000865 S-adenosylmethionine binding site [chemical binding]; other site 484022000866 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 484022000867 SurA N-terminal domain; Region: SurA_N; pfam09312 484022000868 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 484022000869 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 484022000870 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 484022000871 OstA-like protein; Region: OstA; cl00844 484022000872 Organic solvent tolerance protein; Region: OstA_C; pfam04453 484022000873 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 484022000874 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 484022000875 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022000876 active site 484022000877 HIGH motif; other site 484022000878 nucleotide binding site [chemical binding]; other site 484022000879 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 484022000880 KMSK motif region; other site 484022000881 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 484022000882 tRNA binding surface [nucleotide binding]; other site 484022000883 anticodon binding site; other site 484022000884 POT family; Region: PTR2; cl17359 484022000885 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 484022000886 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 484022000887 active site 484022000888 homotetramer interface [polypeptide binding]; other site 484022000889 homodimer interface [polypeptide binding]; other site 484022000890 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 484022000891 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 484022000892 dimer interface [polypeptide binding]; other site 484022000893 active site 484022000894 Schiff base residues; other site 484022000895 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 484022000896 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 484022000897 DNA polymerase III subunit delta'; Validated; Region: PRK08485 484022000898 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 484022000899 putative inner membrane peptidase; Provisional; Region: PRK11778 484022000900 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 484022000901 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 484022000902 tandem repeat interface [polypeptide binding]; other site 484022000903 oligomer interface [polypeptide binding]; other site 484022000904 active site residues [active] 484022000905 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 484022000906 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484022000907 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 484022000908 dimer interface [polypeptide binding]; other site 484022000909 N-terminal domain interface [polypeptide binding]; other site 484022000910 DsrC like protein; Region: DsrC; pfam04358 484022000911 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 484022000912 oxidative damage protection protein; Provisional; Region: PRK05408 484022000913 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 484022000914 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 484022000915 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 484022000916 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 484022000917 Ligand binding site; other site 484022000918 Putative Catalytic site; other site 484022000919 DXD motif; other site 484022000920 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 484022000921 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 484022000922 putative active site [active] 484022000923 YdjC motif; other site 484022000924 Mg binding site [ion binding]; other site 484022000925 putative homodimer interface [polypeptide binding]; other site 484022000926 cell division protein FtsW; Region: ftsW; TIGR02614 484022000927 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 484022000928 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484022000929 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484022000930 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 484022000931 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 484022000932 Mg++ binding site [ion binding]; other site 484022000933 putative catalytic motif [active] 484022000934 putative substrate binding site [chemical binding]; other site 484022000935 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 484022000936 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 484022000937 active site 484022000938 metal-binding site [ion binding] 484022000939 nucleotide-binding site [chemical binding]; other site 484022000940 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 484022000941 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022000942 active site 484022000943 HIGH motif; other site 484022000944 nucleotide binding site [chemical binding]; other site 484022000945 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 484022000946 KMSKS motif; other site 484022000947 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 484022000948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000949 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 484022000950 putative substrate translocation pore; other site 484022000951 ABC transporter ATPase component; Reviewed; Region: PRK11147 484022000952 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 484022000953 Walker A/P-loop; other site 484022000954 ATP binding site [chemical binding]; other site 484022000955 Q-loop/lid; other site 484022000956 ABC transporter signature motif; other site 484022000957 Walker B; other site 484022000958 D-loop; other site 484022000959 H-loop/switch region; other site 484022000960 ABC transporter; Region: ABC_tran_2; pfam12848 484022000961 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484022000962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022000964 putative substrate translocation pore; other site 484022000965 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 484022000966 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 484022000967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000968 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 484022000969 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 484022000970 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 484022000971 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 484022000972 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484022000973 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484022000974 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484022000975 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022000976 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022000977 Integrase core domain; Region: rve; pfam00665 484022000978 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484022000979 active site 484022000980 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 484022000981 putative active site [active] 484022000982 putative metal binding site [ion binding]; other site 484022000983 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 484022000984 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 484022000985 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 484022000986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022000987 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022000988 putative substrate translocation pore; other site 484022000989 threonine synthase; Validated; Region: PRK09225 484022000990 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 484022000991 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022000992 catalytic residue [active] 484022000993 homoserine kinase; Provisional; Region: PRK01212 484022000994 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 484022000995 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 484022000996 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 484022000997 nucleotide binding site [chemical binding]; other site 484022000998 substrate binding site [chemical binding]; other site 484022000999 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 484022001000 dimer interface [polypeptide binding]; other site 484022001001 putative threonine allosteric regulatory site; other site 484022001002 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 484022001003 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 484022001004 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 484022001005 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 484022001006 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 484022001007 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 484022001008 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484022001009 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484022001010 HD domain; Region: HD_3; pfam13023 484022001011 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484022001012 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 484022001013 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484022001014 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484022001015 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 484022001016 dimer interface [polypeptide binding]; other site 484022001017 motif 1; other site 484022001018 active site 484022001019 motif 2; other site 484022001020 motif 3; other site 484022001021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484022001022 Coenzyme A binding pocket [chemical binding]; other site 484022001023 4-alpha-glucanotransferase; Provisional; Region: PRK14508 484022001024 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484022001025 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 484022001026 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022001027 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022001028 Integrase core domain; Region: rve; pfam00665 484022001029 glycogen synthase; Provisional; Region: glgA; PRK00654 484022001030 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 484022001031 ADP-binding pocket [chemical binding]; other site 484022001032 homodimer interface [polypeptide binding]; other site 484022001033 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 484022001034 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 484022001035 ligand binding site; other site 484022001036 oligomer interface; other site 484022001037 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 484022001038 dimer interface [polypeptide binding]; other site 484022001039 N-terminal domain interface [polypeptide binding]; other site 484022001040 sulfate 1 binding site; other site 484022001041 phosphoglucomutase; Region: PLN02307 484022001042 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 484022001043 substrate binding site [chemical binding]; other site 484022001044 dimer interface [polypeptide binding]; other site 484022001045 active site 484022001046 metal binding site [ion binding]; metal-binding site 484022001047 glycogen branching enzyme; Provisional; Region: PRK12313 484022001048 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 484022001049 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 484022001050 active site 484022001051 catalytic site [active] 484022001052 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 484022001053 pullulanase, type I; Region: pulA_typeI; TIGR02104 484022001054 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 484022001055 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 484022001056 Ca binding site [ion binding]; other site 484022001057 active site 484022001058 catalytic site [active] 484022001059 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 484022001060 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 484022001061 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 484022001062 shikimate binding site; other site 484022001063 NAD(P) binding site [chemical binding]; other site 484022001064 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 484022001065 conserved cys residue [active] 484022001066 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 484022001067 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 484022001068 homodimer interface [polypeptide binding]; other site 484022001069 substrate-cofactor binding pocket; other site 484022001070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022001071 catalytic residue [active] 484022001072 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 484022001073 active site 484022001074 catalytic triad [active] 484022001075 oxyanion hole [active] 484022001076 Predicted helicase [General function prediction only]; Region: COG4889 484022001077 CAAX protease self-immunity; Region: Abi; pfam02517 484022001078 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 484022001079 tetramer interface [polypeptide binding]; other site 484022001080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022001081 catalytic residue [active] 484022001082 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 484022001083 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 484022001084 tetramer interface [polypeptide binding]; other site 484022001085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022001086 catalytic residue [active] 484022001087 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 484022001088 lipoyl attachment site [posttranslational modification]; other site 484022001089 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 484022001090 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 484022001091 lysine decarboxylase LdcC; Provisional; Region: PRK15399 484022001092 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 484022001093 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 484022001094 homodimer interface [polypeptide binding]; other site 484022001095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022001096 catalytic residue [active] 484022001097 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 484022001098 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 484022001099 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 484022001100 Walker A/P-loop; other site 484022001101 ATP binding site [chemical binding]; other site 484022001102 Q-loop/lid; other site 484022001103 ABC transporter signature motif; other site 484022001104 Walker B; other site 484022001105 D-loop; other site 484022001106 H-loop/switch region; other site 484022001107 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 484022001108 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 484022001109 FtsX-like permease family; Region: FtsX; pfam02687 484022001110 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 484022001111 active site 484022001112 catalytic residues [active] 484022001113 metal binding site [ion binding]; metal-binding site 484022001114 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 484022001115 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 484022001116 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 484022001117 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 484022001118 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 484022001119 putative active site [active] 484022001120 putative PHP Thumb interface [polypeptide binding]; other site 484022001121 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484022001122 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 484022001123 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484022001124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022001125 putative substrate translocation pore; other site 484022001126 lytic murein transglycosylase; Provisional; Region: PRK11619 484022001127 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484022001128 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484022001129 catalytic residue [active] 484022001130 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 484022001131 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484022001132 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484022001133 catalytic residue [active] 484022001134 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 484022001135 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 484022001136 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 484022001137 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 484022001138 CAP-like domain; other site 484022001139 active site 484022001140 primary dimer interface [polypeptide binding]; other site 484022001141 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 484022001142 PLD-like domain; Region: PLDc_2; pfam13091 484022001143 putative homodimer interface [polypeptide binding]; other site 484022001144 putative active site [active] 484022001145 catalytic site [active] 484022001146 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 484022001147 active site 484022001148 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 484022001149 metal binding site [ion binding]; metal-binding site 484022001150 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 484022001151 DNA-binding site [nucleotide binding]; DNA binding site 484022001152 RNA-binding motif; other site 484022001153 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 484022001154 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 484022001155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 484022001156 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 484022001157 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 484022001158 glutaminase active site [active] 484022001159 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 484022001160 dimer interface [polypeptide binding]; other site 484022001161 active site 484022001162 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 484022001163 dimer interface [polypeptide binding]; other site 484022001164 active site 484022001165 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 484022001166 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 484022001167 Substrate binding site; other site 484022001168 Mg++ binding site; other site 484022001169 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 484022001170 active site 484022001171 substrate binding site [chemical binding]; other site 484022001172 CoA binding site [chemical binding]; other site 484022001173 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 484022001174 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022001175 active site 484022001176 nucleotide binding site [chemical binding]; other site 484022001177 HIGH motif; other site 484022001178 KMSKS motif; other site 484022001179 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 484022001180 nudix motif; other site 484022001181 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 484022001182 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 484022001183 Peptidase family M50; Region: Peptidase_M50; pfam02163 484022001184 active site 484022001185 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022001186 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022001187 Integrase core domain; Region: rve; pfam00665 484022001188 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 484022001189 putative substrate binding region [chemical binding]; other site 484022001190 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 484022001191 Transposase domain (DUF772); Region: DUF772; pfam05598 484022001192 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 484022001193 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 484022001194 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 484022001195 active site 484022001196 HIGH motif; other site 484022001197 KMSKS motif; other site 484022001198 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 484022001199 tRNA binding surface [nucleotide binding]; other site 484022001200 anticodon binding site; other site 484022001201 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 484022001202 dimer interface [polypeptide binding]; other site 484022001203 putative tRNA-binding site [nucleotide binding]; other site 484022001204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022001205 D-galactonate transporter; Region: 2A0114; TIGR00893 484022001206 putative substrate translocation pore; other site 484022001207 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 484022001208 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 484022001209 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 484022001210 intracellular septation protein A; Reviewed; Region: PRK00259 484022001211 Glucokinase; Region: Glucokinase; pfam02685 484022001212 glucokinase, proteobacterial type; Region: glk; TIGR00749 484022001213 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 484022001214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022001215 S-adenosylmethionine binding site [chemical binding]; other site 484022001216 SCP-2 sterol transfer family; Region: SCP2; cl01225 484022001217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 484022001218 ABC1 family; Region: ABC1; cl17513 484022001219 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 484022001220 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 484022001221 nucleotide binding site/active site [active] 484022001222 HIT family signature motif; other site 484022001223 catalytic residue [active] 484022001224 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 484022001225 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484022001226 active site 484022001227 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 484022001228 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 484022001229 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 484022001230 FAD binding domain; Region: FAD_binding_4; pfam01565 484022001231 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 484022001232 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 484022001233 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 484022001234 putative active site [active] 484022001235 GTP-binding protein Der; Reviewed; Region: PRK00093 484022001236 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 484022001237 G1 box; other site 484022001238 GTP/Mg2+ binding site [chemical binding]; other site 484022001239 Switch I region; other site 484022001240 G2 box; other site 484022001241 Switch II region; other site 484022001242 G3 box; other site 484022001243 G4 box; other site 484022001244 G5 box; other site 484022001245 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 484022001246 G1 box; other site 484022001247 GTP/Mg2+ binding site [chemical binding]; other site 484022001248 Switch I region; other site 484022001249 G2 box; other site 484022001250 G3 box; other site 484022001251 Switch II region; other site 484022001252 G4 box; other site 484022001253 G5 box; other site 484022001254 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 484022001255 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 484022001256 malate dehydrogenase; Provisional; Region: PRK13529 484022001257 Malic enzyme, N-terminal domain; Region: malic; pfam00390 484022001258 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 484022001259 NAD(P) binding pocket [chemical binding]; other site 484022001260 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 484022001261 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 484022001262 active site 484022001263 Riboflavin kinase; Region: Flavokinase; pfam01687 484022001264 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 484022001265 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022001266 active site 484022001267 HIGH motif; other site 484022001268 nucleotide binding site [chemical binding]; other site 484022001269 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 484022001270 active site 484022001271 KMSKS motif; other site 484022001272 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 484022001273 tRNA binding surface [nucleotide binding]; other site 484022001274 anticodon binding site; other site 484022001275 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 484022001276 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 484022001277 lipoprotein signal peptidase; Provisional; Region: PRK14787 484022001278 FtsJ-like methyltransferase; Region: FtsJ; cl17430 484022001279 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 484022001280 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 484022001281 Helix-turn-helix domain; Region: HTH_18; pfam12833 484022001282 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 484022001283 active site 484022001284 catalytic triad [active] 484022001285 oxyanion hole [active] 484022001286 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 484022001287 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 484022001288 catalytic triad [active] 484022001289 ParB-like nuclease domain; Region: ParB; smart00470 484022001290 KorB domain; Region: KorB; pfam08535 484022001291 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 484022001292 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 484022001293 P-loop; other site 484022001294 Magnesium ion binding site [ion binding]; other site 484022001295 DNA topoisomerase I; Validated; Region: PRK06599 484022001296 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 484022001297 active site 484022001298 interdomain interaction site; other site 484022001299 putative metal-binding site [ion binding]; other site 484022001300 nucleotide binding site [chemical binding]; other site 484022001301 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 484022001302 domain I; other site 484022001303 DNA binding groove [nucleotide binding] 484022001304 phosphate binding site [ion binding]; other site 484022001305 domain II; other site 484022001306 domain III; other site 484022001307 nucleotide binding site [chemical binding]; other site 484022001308 catalytic site [active] 484022001309 domain IV; other site 484022001310 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 484022001311 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 484022001312 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 484022001313 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 484022001314 O-Antigen ligase; Region: Wzy_C; pfam04932 484022001315 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 484022001316 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 484022001317 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 484022001318 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 484022001319 active site 484022001320 Zn binding site [ion binding]; other site 484022001321 hypothetical protein; Provisional; Region: PRK14682 484022001322 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 484022001323 ATP-grasp domain; Region: ATP-grasp; pfam02222 484022001324 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 484022001325 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 484022001326 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 484022001327 active site 484022001328 substrate binding site [chemical binding]; other site 484022001329 cosubstrate binding site; other site 484022001330 catalytic site [active] 484022001331 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 484022001332 active site 484022001333 ATP binding site [chemical binding]; other site 484022001334 substrate binding site [chemical binding]; other site 484022001335 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 484022001336 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 484022001337 ATP-grasp domain; Region: ATP-grasp_4; cl17255 484022001338 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 484022001339 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 484022001340 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 484022001341 dimerization interface [polypeptide binding]; other site 484022001342 putative ATP binding site [chemical binding]; other site 484022001343 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 484022001344 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 484022001345 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 484022001346 homodimer interface [polypeptide binding]; other site 484022001347 NADP binding site [chemical binding]; other site 484022001348 substrate binding site [chemical binding]; other site 484022001349 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 484022001350 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 484022001351 active site 484022001352 putative major pilin subunit; Provisional; Region: PRK10574 484022001353 Pilin (bacterial filament); Region: Pilin; pfam00114 484022001354 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 484022001355 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 484022001356 Walker A/P-loop; other site 484022001357 ATP binding site [chemical binding]; other site 484022001358 Q-loop/lid; other site 484022001359 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 484022001360 ABC transporter signature motif; other site 484022001361 Walker B; other site 484022001362 D-loop; other site 484022001363 H-loop/switch region; other site 484022001364 aspartate aminotransferase; Provisional; Region: PRK07568 484022001365 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484022001366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022001367 homodimer interface [polypeptide binding]; other site 484022001368 catalytic residue [active] 484022001369 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 484022001370 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 484022001371 substrate binding site [chemical binding]; other site 484022001372 catalytic Zn binding site [ion binding]; other site 484022001373 NAD binding site [chemical binding]; other site 484022001374 structural Zn binding site [ion binding]; other site 484022001375 dimer interface [polypeptide binding]; other site 484022001376 Cupin domain; Region: Cupin_2; cl17218 484022001377 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 484022001378 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 484022001379 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 484022001380 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 484022001381 E-class dimer interface [polypeptide binding]; other site 484022001382 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 484022001383 P-class dimer interface [polypeptide binding]; other site 484022001384 active site 484022001385 Cu2+ binding site [ion binding]; other site 484022001386 Zn2+ binding site [ion binding]; other site 484022001387 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022001388 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022001389 Integrase core domain; Region: rve; pfam00665 484022001390 methionine sulfoxide reductase B; Provisional; Region: PRK00222 484022001391 SelR domain; Region: SelR; pfam01641 484022001392 PQ loop repeat; Region: PQ-loop; pfam04193 484022001393 PQ loop repeat; Region: PQ-loop; pfam04193 484022001394 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 484022001395 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 484022001396 Tetramer interface [polypeptide binding]; other site 484022001397 active site 484022001398 FMN-binding site [chemical binding]; other site 484022001399 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 484022001400 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 484022001401 PilZ domain; Region: PilZ; pfam07238 484022001402 DNA repair protein RadA; Provisional; Region: PRK11823 484022001403 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 484022001404 Walker A motif/ATP binding site; other site 484022001405 ATP binding site [chemical binding]; other site 484022001406 Walker B motif; other site 484022001407 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 484022001408 Colicin V production protein; Region: Colicin_V; pfam02674 484022001409 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 484022001410 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 484022001411 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 484022001412 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 484022001413 putative active site [active] 484022001414 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484022001415 putative DNA binding site [nucleotide binding]; other site 484022001416 dimerization interface [polypeptide binding]; other site 484022001417 putative Zn2+ binding site [ion binding]; other site 484022001418 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 484022001419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484022001420 Soluble P-type ATPase [General function prediction only]; Region: COG4087 484022001421 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 484022001422 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 484022001423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484022001424 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 484022001425 putative dimerization interface [polypeptide binding]; other site 484022001426 LemA family; Region: LemA; cl00742 484022001427 heat shock protein HtpX; Provisional; Region: PRK02870 484022001428 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 484022001429 ribonuclease PH; Reviewed; Region: rph; PRK00173 484022001430 Ribonuclease PH; Region: RNase_PH_bact; cd11362 484022001431 hexamer interface [polypeptide binding]; other site 484022001432 active site 484022001433 Chorismate lyase; Region: Chor_lyase; cl01230 484022001434 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 484022001435 UbiA prenyltransferase family; Region: UbiA; pfam01040 484022001436 Protein of unknown function, DUF393; Region: DUF393; pfam04134 484022001437 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 484022001438 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 484022001439 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 484022001440 hypothetical protein; Provisional; Region: PRK10621 484022001441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 484022001442 YheO-like PAS domain; Region: PAS_6; pfam08348 484022001443 HTH domain; Region: HTH_22; pfam13309 484022001444 bile acid transporter; Region: bass; TIGR00841 484022001445 Sodium Bile acid symporter family; Region: SBF; cl17470 484022001446 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 484022001447 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 484022001448 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 484022001449 DNA photolyase; Region: DNA_photolyase; pfam00875 484022001450 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 484022001451 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 484022001452 C factor cell-cell signaling protein; Provisional; Region: PRK09009 484022001453 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 484022001454 NADP binding site [chemical binding]; other site 484022001455 homodimer interface [polypeptide binding]; other site 484022001456 active site 484022001457 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 484022001458 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 484022001459 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484022001460 FeS/SAM binding site; other site 484022001461 TRAM domain; Region: TRAM; cl01282 484022001462 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 484022001463 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 484022001464 ligand binding site [chemical binding]; other site 484022001465 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 484022001466 TolB amino-terminal domain; Region: TolB_N; pfam04052 484022001467 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 484022001468 Gram-negative bacterial tonB protein; Region: TonB; cl10048 484022001469 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 484022001470 TolR protein; Region: tolR; TIGR02801 484022001471 TolQ protein; Region: tolQ; TIGR02796 484022001472 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 484022001473 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 484022001474 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 484022001475 homotrimer interaction site [polypeptide binding]; other site 484022001476 active site 484022001477 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 484022001478 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 484022001479 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 484022001480 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 484022001481 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 484022001482 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 484022001483 ligand binding site [chemical binding]; other site 484022001484 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022001485 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022001486 Integrase core domain; Region: rve; pfam00665 484022001487 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 484022001488 DNA protecting protein DprA; Region: dprA; TIGR00732 484022001489 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 484022001490 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 484022001491 TrkA-C domain; Region: TrkA_C; pfam02080 484022001492 TrkA-C domain; Region: TrkA_C; pfam02080 484022001493 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 484022001494 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 484022001495 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484022001496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022001497 homodimer interface [polypeptide binding]; other site 484022001498 catalytic residue [active] 484022001499 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 484022001500 tail fiber protein; Region: PHA00430 484022001501 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 484022001502 ArsC family; Region: ArsC; pfam03960 484022001503 catalytic residue [active] 484022001504 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 484022001505 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 484022001506 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 484022001507 nudix motif; other site 484022001508 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 484022001509 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 484022001510 putative metal binding site [ion binding]; other site 484022001511 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 484022001512 Fumarase C-terminus; Region: Fumerase_C; pfam05683 484022001513 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 484022001514 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 484022001515 ssDNA binding site; other site 484022001516 generic binding surface II; other site 484022001517 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022001518 ATP binding site [chemical binding]; other site 484022001519 putative Mg++ binding site [ion binding]; other site 484022001520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022001521 nucleotide binding region [chemical binding]; other site 484022001522 ATP-binding site [chemical binding]; other site 484022001523 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 484022001524 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 484022001525 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 484022001526 septum formation inhibitor; Reviewed; Region: minC; PRK04804 484022001527 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 484022001528 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 484022001529 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 484022001530 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 484022001531 Switch I; other site 484022001532 Switch II; other site 484022001533 cell division topological specificity factor MinE; Provisional; Region: PRK13990 484022001534 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 484022001535 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 484022001536 Walker A/P-loop; other site 484022001537 ATP binding site [chemical binding]; other site 484022001538 Q-loop/lid; other site 484022001539 ABC transporter signature motif; other site 484022001540 Walker B; other site 484022001541 D-loop; other site 484022001542 H-loop/switch region; other site 484022001543 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 484022001544 Permease; Region: Permease; pfam02405 484022001545 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 484022001546 mce related protein; Region: MCE; pfam02470 484022001547 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 484022001548 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 484022001549 anti sigma factor interaction site; other site 484022001550 regulatory phosphorylation site [posttranslational modification]; other site 484022001551 BolA-like protein; Region: BolA; cl00386 484022001552 VacJ like lipoprotein; Region: VacJ; cl01073 484022001553 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 484022001554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022001555 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 484022001556 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 484022001557 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 484022001558 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 484022001559 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 484022001560 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484022001561 catalytic residue [active] 484022001562 Transposase, Mutator family; Region: Transposase_mut; pfam00872 484022001563 MULE transposase domain; Region: MULE; pfam10551 484022001564 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 484022001565 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 484022001566 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 484022001567 putative sugar binding site [chemical binding]; other site 484022001568 catalytic residues [active] 484022001569 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 484022001570 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484022001571 Coenzyme A binding pocket [chemical binding]; other site 484022001572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022001573 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022001574 putative substrate translocation pore; other site 484022001575 HemK family putative methylases; Region: hemK_fam; TIGR00536 484022001576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022001577 S-adenosylmethionine binding site [chemical binding]; other site 484022001578 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 484022001579 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 484022001580 active site 484022001581 HIGH motif; other site 484022001582 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 484022001583 KMSKS motif; other site 484022001584 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 484022001585 tRNA binding surface [nucleotide binding]; other site 484022001586 anticodon binding site; other site 484022001587 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 484022001588 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 484022001589 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 484022001590 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 484022001591 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 484022001592 Domain of unknown function DUF21; Region: DUF21; pfam01595 484022001593 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 484022001594 Transporter associated domain; Region: CorC_HlyC; smart01091 484022001595 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 484022001596 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 484022001597 DXD motif; other site 484022001598 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 484022001599 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 484022001600 Na binding site [ion binding]; other site 484022001601 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 484022001602 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 484022001603 putative active site [active] 484022001604 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 484022001605 lysine transporter; Provisional; Region: PRK10836 484022001606 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 484022001607 active site 484022001608 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 484022001609 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 484022001610 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 484022001611 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 484022001612 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 484022001613 Cation transport protein; Region: TrkH; cl17365 484022001614 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 484022001615 ProQ/FINO family; Region: ProQ; pfam04352 484022001616 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 484022001617 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 484022001618 SnoaL-like domain; Region: SnoaL_2; pfam12680 484022001619 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 484022001620 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 484022001621 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 484022001622 FAD binding pocket [chemical binding]; other site 484022001623 FAD binding motif [chemical binding]; other site 484022001624 phosphate binding motif [ion binding]; other site 484022001625 beta-alpha-beta structure motif; other site 484022001626 NAD binding pocket [chemical binding]; other site 484022001627 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 484022001628 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 484022001629 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 484022001630 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 484022001631 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 484022001632 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 484022001633 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 484022001634 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 484022001635 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 484022001636 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 484022001637 active site 484022001638 multimer interface [polypeptide binding]; other site 484022001639 CTP synthetase; Validated; Region: pyrG; PRK05380 484022001640 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 484022001641 Catalytic site [active] 484022001642 active site 484022001643 UTP binding site [chemical binding]; other site 484022001644 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 484022001645 active site 484022001646 putative oxyanion hole; other site 484022001647 catalytic triad [active] 484022001648 hypothetical protein; Provisional; Region: PRK11588 484022001649 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 484022001650 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 484022001651 argininosuccinate synthase; Provisional; Region: PRK13820 484022001652 ANP binding site [chemical binding]; other site 484022001653 Substrate Binding Site II [chemical binding]; other site 484022001654 Substrate Binding Site I [chemical binding]; other site 484022001655 Lyase; Region: Lyase_1; pfam00206 484022001656 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 484022001657 tetramer interface [polypeptide binding]; other site 484022001658 Arginine repressor [Transcription]; Region: ArgR; COG1438 484022001659 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 484022001660 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 484022001661 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 484022001662 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484022001663 inhibitor-cofactor binding pocket; inhibition site 484022001664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022001665 catalytic residue [active] 484022001666 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 484022001667 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 484022001668 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 484022001669 heterotetramer interface [polypeptide binding]; other site 484022001670 active site pocket [active] 484022001671 cleavage site 484022001672 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 484022001673 nucleotide binding site [chemical binding]; other site 484022001674 N-acetyl-L-glutamate binding site [chemical binding]; other site 484022001675 ornithine carbamoyltransferase; Provisional; Region: PRK00779 484022001676 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 484022001677 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 484022001678 heat shock protein 90; Provisional; Region: PRK05218 484022001679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484022001680 ATP binding site [chemical binding]; other site 484022001681 Mg2+ binding site [ion binding]; other site 484022001682 G-X-G motif; other site 484022001683 Ion transport protein; Region: Ion_trans; pfam00520 484022001684 Ion channel; Region: Ion_trans_2; pfam07885 484022001685 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 484022001686 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 484022001687 alphaNTD homodimer interface [polypeptide binding]; other site 484022001688 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 484022001689 alphaNTD - beta interaction site [polypeptide binding]; other site 484022001690 alphaNTD - beta' interaction site [polypeptide binding]; other site 484022001691 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 484022001692 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 484022001693 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 484022001694 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484022001695 RNA binding surface [nucleotide binding]; other site 484022001696 30S ribosomal protein S11; Validated; Region: PRK05309 484022001697 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 484022001698 30S ribosomal protein S13; Region: bact_S13; TIGR03631 484022001699 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 484022001700 SecY translocase; Region: SecY; pfam00344 484022001701 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 484022001702 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 484022001703 23S rRNA binding site [nucleotide binding]; other site 484022001704 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 484022001705 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 484022001706 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 484022001707 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 484022001708 23S rRNA interface [nucleotide binding]; other site 484022001709 L21e interface [polypeptide binding]; other site 484022001710 5S rRNA interface [nucleotide binding]; other site 484022001711 L27 interface [polypeptide binding]; other site 484022001712 L5 interface [polypeptide binding]; other site 484022001713 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 484022001714 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 484022001715 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 484022001716 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 484022001717 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 484022001718 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 484022001719 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 484022001720 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 484022001721 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 484022001722 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 484022001723 RNA binding site [nucleotide binding]; other site 484022001724 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 484022001725 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 484022001726 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 484022001727 23S rRNA interface [nucleotide binding]; other site 484022001728 putative translocon interaction site; other site 484022001729 signal recognition particle (SRP54) interaction site; other site 484022001730 L23 interface [polypeptide binding]; other site 484022001731 trigger factor interaction site; other site 484022001732 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 484022001733 23S rRNA interface [nucleotide binding]; other site 484022001734 5S rRNA interface [nucleotide binding]; other site 484022001735 putative antibiotic binding site [chemical binding]; other site 484022001736 L25 interface [polypeptide binding]; other site 484022001737 L27 interface [polypeptide binding]; other site 484022001738 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 484022001739 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 484022001740 G-X-X-G motif; other site 484022001741 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 484022001742 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 484022001743 putative translocon binding site; other site 484022001744 protein-rRNA interface [nucleotide binding]; other site 484022001745 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 484022001746 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 484022001747 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 484022001748 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 484022001749 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 484022001750 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 484022001751 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 484022001752 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 484022001753 elongation factor G; Reviewed; Region: PRK00007 484022001754 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 484022001755 G1 box; other site 484022001756 putative GEF interaction site [polypeptide binding]; other site 484022001757 GTP/Mg2+ binding site [chemical binding]; other site 484022001758 Switch I region; other site 484022001759 G2 box; other site 484022001760 G3 box; other site 484022001761 Switch II region; other site 484022001762 G4 box; other site 484022001763 G5 box; other site 484022001764 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 484022001765 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 484022001766 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 484022001767 30S ribosomal protein S7; Validated; Region: PRK05302 484022001768 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 484022001769 S17 interaction site [polypeptide binding]; other site 484022001770 S8 interaction site; other site 484022001771 16S rRNA interaction site [nucleotide binding]; other site 484022001772 streptomycin interaction site [chemical binding]; other site 484022001773 23S rRNA interaction site [nucleotide binding]; other site 484022001774 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 484022001775 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 484022001776 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 484022001777 trimer interface [polypeptide binding]; other site 484022001778 active site 484022001779 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 484022001780 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 484022001781 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 484022001782 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 484022001783 catalytic residue [active] 484022001784 putative FPP diphosphate binding site; other site 484022001785 putative FPP binding hydrophobic cleft; other site 484022001786 dimer interface [polypeptide binding]; other site 484022001787 putative IPP diphosphate binding site; other site 484022001788 ribosome recycling factor; Reviewed; Region: frr; PRK00083 484022001789 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 484022001790 hinge region; other site 484022001791 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 484022001792 putative nucleotide binding site [chemical binding]; other site 484022001793 uridine monophosphate binding site [chemical binding]; other site 484022001794 homohexameric interface [polypeptide binding]; other site 484022001795 elongation factor Ts; Provisional; Region: tsf; PRK09377 484022001796 UBA/TS-N domain; Region: UBA; pfam00627 484022001797 Elongation factor TS; Region: EF_TS; pfam00889 484022001798 Elongation factor TS; Region: EF_TS; pfam00889 484022001799 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 484022001800 rRNA interaction site [nucleotide binding]; other site 484022001801 S8 interaction site; other site 484022001802 putative laminin-1 binding site; other site 484022001803 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 484022001804 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 484022001805 folate binding site [chemical binding]; other site 484022001806 NADP+ binding site [chemical binding]; other site 484022001807 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 484022001808 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 484022001809 dimer interface [polypeptide binding]; other site 484022001810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022001811 catalytic residue [active] 484022001812 serine O-acetyltransferase; Region: cysE; TIGR01172 484022001813 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 484022001814 trimer interface [polypeptide binding]; other site 484022001815 active site 484022001816 substrate binding site [chemical binding]; other site 484022001817 CoA binding site [chemical binding]; other site 484022001818 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 484022001819 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 484022001820 HIGH motif; other site 484022001821 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 484022001822 active site 484022001823 KMSKS motif; other site 484022001824 fumarate hydratase; Reviewed; Region: fumC; PRK00485 484022001825 Class II fumarases; Region: Fumarase_classII; cd01362 484022001826 active site 484022001827 tetramer interface [polypeptide binding]; other site 484022001828 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 484022001829 dimer interface [polypeptide binding]; other site 484022001830 FMN binding site [chemical binding]; other site 484022001831 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 484022001832 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 484022001833 phosphate binding site [ion binding]; other site 484022001834 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 484022001835 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 484022001836 putative catalytic cysteine [active] 484022001837 gamma-glutamyl kinase; Provisional; Region: PRK05429 484022001838 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 484022001839 nucleotide binding site [chemical binding]; other site 484022001840 homotetrameric interface [polypeptide binding]; other site 484022001841 putative phosphate binding site [ion binding]; other site 484022001842 putative allosteric binding site; other site 484022001843 PUA domain; Region: PUA; pfam01472 484022001844 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 484022001845 nudix motif; other site 484022001846 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 484022001847 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 484022001848 Fic/DOC family; Region: Fic; cl00960 484022001849 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 484022001850 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 484022001851 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 484022001852 HIGH motif; other site 484022001853 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 484022001854 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 484022001855 active site 484022001856 KMSKS motif; other site 484022001857 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 484022001858 tRNA binding surface [nucleotide binding]; other site 484022001859 anticodon binding site; other site 484022001860 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 484022001861 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 484022001862 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 484022001863 putative substrate binding pocket [chemical binding]; other site 484022001864 AC domain interface; other site 484022001865 catalytic triad [active] 484022001866 AB domain interface; other site 484022001867 interchain disulfide; other site 484022001868 Oxygen tolerance; Region: BatD; pfam13584 484022001869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 484022001870 TPR motif; other site 484022001871 binding surface 484022001872 TPR repeat; Region: TPR_11; pfam13414 484022001873 von Willebrand factor type A domain; Region: VWA_2; pfam13519 484022001874 metal ion-dependent adhesion site (MIDAS); other site 484022001875 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 484022001876 metal ion-dependent adhesion site (MIDAS); other site 484022001877 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 484022001878 Protein of unknown function DUF58; Region: DUF58; pfam01882 484022001879 MoxR-like ATPases [General function prediction only]; Region: COG0714 484022001880 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 484022001881 Walker A motif; other site 484022001882 ATP binding site [chemical binding]; other site 484022001883 Walker B motif; other site 484022001884 arginine finger; other site 484022001885 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 484022001886 pyridoxamine kinase; Validated; Region: PRK05756 484022001887 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 484022001888 dimer interface [polypeptide binding]; other site 484022001889 pyridoxal binding site [chemical binding]; other site 484022001890 ATP binding site [chemical binding]; other site 484022001891 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 484022001892 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 484022001893 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 484022001894 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 484022001895 trimer interface [polypeptide binding]; other site 484022001896 active site 484022001897 UDP-GlcNAc binding site [chemical binding]; other site 484022001898 lipid binding site [chemical binding]; lipid-binding site 484022001899 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 484022001900 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 484022001901 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 484022001902 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 484022001903 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484022001904 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 484022001905 substrate binding pocket [chemical binding]; other site 484022001906 membrane-bound complex binding site; other site 484022001907 hinge residues; other site 484022001908 primosome assembly protein PriA; Validated; Region: PRK05580 484022001909 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022001910 ATP binding site [chemical binding]; other site 484022001911 putative Mg++ binding site [ion binding]; other site 484022001912 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 484022001913 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 484022001914 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 484022001915 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 484022001916 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 484022001917 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 484022001918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022001919 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022001920 putative substrate translocation pore; other site 484022001921 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 484022001922 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 484022001923 intersubunit interface [polypeptide binding]; other site 484022001924 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 484022001925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484022001926 Walker A/P-loop; other site 484022001927 ATP binding site [chemical binding]; other site 484022001928 Q-loop/lid; other site 484022001929 ABC transporter signature motif; other site 484022001930 Walker B; other site 484022001931 D-loop; other site 484022001932 H-loop/switch region; other site 484022001933 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 484022001934 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484022001935 ABC-ATPase subunit interface; other site 484022001936 dimer interface [polypeptide binding]; other site 484022001937 putative PBP binding regions; other site 484022001938 Dienelactone hydrolase family; Region: DLH; pfam01738 484022001939 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 484022001940 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484022001941 active site 484022001942 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 484022001943 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 484022001944 GDP-binding site [chemical binding]; other site 484022001945 ACT binding site; other site 484022001946 IMP binding site; other site 484022001947 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 484022001948 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 484022001949 purine monophosphate binding site [chemical binding]; other site 484022001950 dimer interface [polypeptide binding]; other site 484022001951 putative catalytic residues [active] 484022001952 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 484022001953 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 484022001954 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 484022001955 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 484022001956 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 484022001957 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 484022001958 DNA polymerase III, delta subunit; Region: holA; TIGR01128 484022001959 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 484022001960 glutamine synthetase; Region: PLN02284 484022001961 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 484022001962 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 484022001963 Glutaminase; Region: Glutaminase; cl00907 484022001964 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 484022001965 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 484022001966 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 484022001967 hypothetical protein; Provisional; Region: PRK05208 484022001968 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 484022001969 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 484022001970 dimer interface [polypeptide binding]; other site 484022001971 putative anticodon binding site; other site 484022001972 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 484022001973 motif 1; other site 484022001974 active site 484022001975 motif 2; other site 484022001976 motif 3; other site 484022001977 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 484022001978 GIY-YIG motif/motif A; other site 484022001979 putative active site [active] 484022001980 putative metal binding site [ion binding]; other site 484022001981 peptide chain release factor 2; Validated; Region: prfB; PRK00578 484022001982 This domain is found in peptide chain release factors; Region: PCRF; smart00937 484022001983 RF-1 domain; Region: RF-1; pfam00472 484022001984 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 484022001985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484022001986 Walker A motif; other site 484022001987 ATP binding site [chemical binding]; other site 484022001988 Walker B motif; other site 484022001989 DNA polymerase III subunit delta'; Validated; Region: PRK08485 484022001990 arginine finger; other site 484022001991 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 484022001992 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 484022001993 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 484022001994 cell division protein FtsZ; Validated; Region: PRK09330 484022001995 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 484022001996 nucleotide binding site [chemical binding]; other site 484022001997 SulA interaction site; other site 484022001998 cell division protein FtsA; Region: ftsA; TIGR01174 484022001999 Cell division protein FtsA; Region: FtsA; smart00842 484022002000 Cell division protein FtsA; Region: FtsA; pfam14450 484022002001 Cell division protein FtsQ; Region: FtsQ; pfam03799 484022002002 D-alanyl-alanine synthetase A; Provisional; Region: PRK14569 484022002003 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 484022002004 ATP-grasp domain; Region: ATP-grasp_4; cl17255 484022002005 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 484022002006 nucleoside/Zn binding site; other site 484022002007 dimer interface [polypeptide binding]; other site 484022002008 catalytic motif [active] 484022002009 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 484022002010 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 484022002011 RNA binding site [nucleotide binding]; other site 484022002012 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 484022002013 RNA binding site [nucleotide binding]; other site 484022002014 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 484022002015 RNA binding site [nucleotide binding]; other site 484022002016 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 484022002017 RNA binding site [nucleotide binding]; other site 484022002018 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 484022002019 RNA binding site [nucleotide binding]; other site 484022002020 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 484022002021 RNA binding site [nucleotide binding]; other site 484022002022 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 484022002023 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 484022002024 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 484022002025 putative acyl-acceptor binding pocket; other site 484022002026 Competence protein; Region: Competence; pfam03772 484022002027 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 484022002028 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002029 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022002030 Integrase core domain; Region: rve; pfam00665 484022002031 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 484022002032 Competence protein; Region: Competence; pfam03772 484022002033 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 484022002034 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 484022002035 ATP-grasp domain; Region: ATP-grasp_4; cl17255 484022002036 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 484022002037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484022002038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 484022002039 Coenzyme A binding pocket [chemical binding]; other site 484022002040 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 484022002041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484022002042 dimer interface [polypeptide binding]; other site 484022002043 conserved gate region; other site 484022002044 putative PBP binding loops; other site 484022002045 ABC-ATPase subunit interface; other site 484022002046 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 484022002047 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 484022002048 Walker A/P-loop; other site 484022002049 ATP binding site [chemical binding]; other site 484022002050 Q-loop/lid; other site 484022002051 ABC transporter signature motif; other site 484022002052 Walker B; other site 484022002053 D-loop; other site 484022002054 H-loop/switch region; other site 484022002055 YGGT family; Region: YGGT; pfam02325 484022002056 YGGT family; Region: YGGT; pfam02325 484022002057 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 484022002058 putative active site [active] 484022002059 Zn binding site [ion binding]; other site 484022002060 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 484022002061 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 484022002062 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 484022002063 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 484022002064 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 484022002065 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 484022002066 trimer interface [polypeptide binding]; other site 484022002067 putative metal binding site [ion binding]; other site 484022002068 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 484022002069 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 484022002070 TrkA-N domain; Region: TrkA_N; pfam02254 484022002071 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 484022002072 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 484022002073 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 484022002074 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 484022002075 classical (c) SDRs; Region: SDR_c; cd05233 484022002076 NAD(P) binding site [chemical binding]; other site 484022002077 active site 484022002078 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 484022002079 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 484022002080 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 484022002081 Walker A/P-loop; other site 484022002082 ATP binding site [chemical binding]; other site 484022002083 Q-loop/lid; other site 484022002084 ABC transporter signature motif; other site 484022002085 Walker B; other site 484022002086 D-loop; other site 484022002087 H-loop/switch region; other site 484022002088 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 484022002089 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 484022002090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484022002091 dimer interface [polypeptide binding]; other site 484022002092 conserved gate region; other site 484022002093 putative PBP binding loops; other site 484022002094 ABC-ATPase subunit interface; other site 484022002095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484022002096 dimer interface [polypeptide binding]; other site 484022002097 conserved gate region; other site 484022002098 putative PBP binding loops; other site 484022002099 ABC-ATPase subunit interface; other site 484022002100 Zinc-finger domain; Region: zf-CHCC; cl01821 484022002101 camphor resistance protein CrcB; Provisional; Region: PRK14226 484022002102 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 484022002103 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 484022002104 domain interfaces; other site 484022002105 active site 484022002106 putative hydrolase; Provisional; Region: PRK11460 484022002107 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 484022002108 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 484022002109 RNB domain; Region: RNB; pfam00773 484022002110 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 484022002111 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 484022002112 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 484022002113 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 484022002114 dimer interface [polypeptide binding]; other site 484022002115 anticodon binding site; other site 484022002116 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 484022002117 homodimer interface [polypeptide binding]; other site 484022002118 motif 1; other site 484022002119 active site 484022002120 motif 2; other site 484022002121 GAD domain; Region: GAD; pfam02938 484022002122 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 484022002123 active site 484022002124 motif 3; other site 484022002125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484022002126 Coenzyme A binding pocket [chemical binding]; other site 484022002127 Predicted amidohydrolase [General function prediction only]; Region: COG0388 484022002128 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 484022002129 putative active site [active] 484022002130 catalytic triad [active] 484022002131 putative dimer interface [polypeptide binding]; other site 484022002132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002133 putative substrate translocation pore; other site 484022002134 D-galactonate transporter; Region: 2A0114; TIGR00893 484022002135 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 484022002136 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 484022002137 succinic semialdehyde dehydrogenase; Region: PLN02278 484022002138 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 484022002139 tetramerization interface [polypeptide binding]; other site 484022002140 NAD(P) binding site [chemical binding]; other site 484022002141 catalytic residues [active] 484022002142 phosphate acetyltransferase; Reviewed; Region: PRK05632 484022002143 DRTGG domain; Region: DRTGG; pfam07085 484022002144 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 484022002145 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 484022002146 propionate/acetate kinase; Provisional; Region: PRK12379 484022002147 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 484022002148 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 484022002149 dimer interface [polypeptide binding]; other site 484022002150 ssDNA binding site [nucleotide binding]; other site 484022002151 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484022002152 recombination regulator RecX; Reviewed; Region: recX; PRK00117 484022002153 recombinase A; Provisional; Region: recA; PRK09354 484022002154 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 484022002155 hexamer interface [polypeptide binding]; other site 484022002156 Walker A motif; other site 484022002157 ATP binding site [chemical binding]; other site 484022002158 Walker B motif; other site 484022002159 preprotein translocase subunit SecB; Provisional; Region: PRK13031 484022002160 SecA binding site; other site 484022002161 Preprotein binding site; other site 484022002162 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 484022002163 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 484022002164 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 484022002165 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 484022002166 tandem repeat interface [polypeptide binding]; other site 484022002167 oligomer interface [polypeptide binding]; other site 484022002168 active site residues [active] 484022002169 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002170 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022002171 Integrase core domain; Region: rve; pfam00665 484022002172 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 484022002173 dimer interface [polypeptide binding]; other site 484022002174 [2Fe-2S] cluster binding site [ion binding]; other site 484022002175 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 484022002176 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 484022002177 dimer interface [polypeptide binding]; other site 484022002178 PYR/PP interface [polypeptide binding]; other site 484022002179 TPP binding site [chemical binding]; other site 484022002180 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484022002181 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 484022002182 TPP-binding site [chemical binding]; other site 484022002183 dimer interface [polypeptide binding]; other site 484022002184 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 484022002185 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 484022002186 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 484022002187 catalytic motif [active] 484022002188 Zn binding site [ion binding]; other site 484022002189 RibD C-terminal domain; Region: RibD_C; pfam01872 484022002190 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 484022002191 Lumazine binding domain; Region: Lum_binding; pfam00677 484022002192 Lumazine binding domain; Region: Lum_binding; pfam00677 484022002193 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 484022002194 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 484022002195 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 484022002196 dimerization interface [polypeptide binding]; other site 484022002197 active site 484022002198 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 484022002199 homopentamer interface [polypeptide binding]; other site 484022002200 active site 484022002201 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 484022002202 active site 484022002203 catalytic residues [active] 484022002204 metal binding site [ion binding]; metal-binding site 484022002205 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 484022002206 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 484022002207 GTP-binding protein LepA; Provisional; Region: PRK05433 484022002208 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 484022002209 G1 box; other site 484022002210 putative GEF interaction site [polypeptide binding]; other site 484022002211 GTP/Mg2+ binding site [chemical binding]; other site 484022002212 Switch I region; other site 484022002213 G2 box; other site 484022002214 G3 box; other site 484022002215 Switch II region; other site 484022002216 G4 box; other site 484022002217 G5 box; other site 484022002218 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 484022002219 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 484022002220 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 484022002221 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 484022002222 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 484022002223 putative substrate binding pocket [chemical binding]; other site 484022002224 trimer interface [polypeptide binding]; other site 484022002225 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 484022002226 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 484022002227 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 484022002228 dimer interface [polypeptide binding]; other site 484022002229 active site 484022002230 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 484022002231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002232 putative substrate translocation pore; other site 484022002233 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 484022002234 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484022002235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484022002236 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 484022002237 putative effector binding pocket; other site 484022002238 dimerization interface [polypeptide binding]; other site 484022002239 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 484022002240 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 484022002241 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484022002242 catalytic residue [active] 484022002243 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 484022002244 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 484022002245 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 484022002246 aromatic amino acid transport protein; Region: araaP; TIGR00837 484022002247 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 484022002248 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 484022002249 putative FMN binding site [chemical binding]; other site 484022002250 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484022002251 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 484022002252 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 484022002253 Phosphoesterase family; Region: Phosphoesterase; pfam04185 484022002254 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 484022002255 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 484022002256 putative metal dependent hydrolase; Provisional; Region: PRK11598 484022002257 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 484022002258 Sulfatase; Region: Sulfatase; pfam00884 484022002259 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 484022002260 LamB/YcsF family protein; Provisional; Region: PRK05406 484022002261 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 484022002262 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 484022002263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002264 putative substrate translocation pore; other site 484022002265 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484022002266 Ligand Binding Site [chemical binding]; other site 484022002267 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484022002268 Ligand Binding Site [chemical binding]; other site 484022002269 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 484022002270 PLD-like domain; Region: PLDc_2; pfam13091 484022002271 putative homodimer interface [polypeptide binding]; other site 484022002272 putative active site [active] 484022002273 catalytic site [active] 484022002274 DEAD-like helicases superfamily; Region: DEXDc; smart00487 484022002275 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022002276 ATP binding site [chemical binding]; other site 484022002277 putative Mg++ binding site [ion binding]; other site 484022002278 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022002279 nucleotide binding region [chemical binding]; other site 484022002280 ATP-binding site [chemical binding]; other site 484022002281 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 484022002282 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 484022002283 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 484022002284 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 484022002285 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 484022002286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484022002287 active site 484022002288 motif I; other site 484022002289 motif II; other site 484022002290 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 484022002291 Predicted methyltransferases [General function prediction only]; Region: COG0313 484022002292 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 484022002293 putative SAM binding site [chemical binding]; other site 484022002294 putative homodimer interface [polypeptide binding]; other site 484022002295 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 484022002296 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484022002297 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484022002298 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484022002299 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 484022002300 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 484022002301 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 484022002302 shikimate binding site; other site 484022002303 NAD(P) binding site [chemical binding]; other site 484022002304 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 484022002305 Ribonuclease P; Region: Ribonuclease_P; pfam00825 484022002306 hypothetical protein; Provisional; Region: PRK14375 484022002307 membrane protein insertase; Provisional; Region: PRK01318 484022002308 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 484022002309 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 484022002310 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 484022002311 putative acyl-acceptor binding pocket; other site 484022002312 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 484022002313 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 484022002314 putative acyl-acceptor binding pocket; other site 484022002315 elongation factor P; Validated; Region: PRK00529 484022002316 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 484022002317 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 484022002318 RNA binding site [nucleotide binding]; other site 484022002319 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 484022002320 RNA binding site [nucleotide binding]; other site 484022002321 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 484022002322 catalytic site [active] 484022002323 putative active site [active] 484022002324 putative substrate binding site [chemical binding]; other site 484022002325 dimer interface [polypeptide binding]; other site 484022002326 pyruvate phosphate dikinase; Provisional; Region: PRK09279 484022002327 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 484022002328 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 484022002329 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 484022002330 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 484022002331 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 484022002332 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 484022002333 homodimer interface [polypeptide binding]; other site 484022002334 substrate-cofactor binding pocket; other site 484022002335 catalytic residue [active] 484022002336 2-isopropylmalate synthase; Validated; Region: PRK00915 484022002337 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 484022002338 active site 484022002339 catalytic residues [active] 484022002340 metal binding site [ion binding]; metal-binding site 484022002341 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 484022002342 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 484022002343 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 484022002344 substrate binding site [chemical binding]; other site 484022002345 ligand binding site [chemical binding]; other site 484022002346 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 484022002347 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 484022002348 substrate binding site [chemical binding]; other site 484022002349 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 484022002350 tartrate dehydrogenase; Region: TTC; TIGR02089 484022002351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002352 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 484022002353 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 484022002354 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 484022002355 substrate binding [chemical binding]; other site 484022002356 active site 484022002357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002358 putative substrate translocation pore; other site 484022002359 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 484022002360 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 484022002361 putative active site [active] 484022002362 dimerization interface [polypeptide binding]; other site 484022002363 putative tRNAtyr binding site [nucleotide binding]; other site 484022002364 prephenate dehydrogenase; Validated; Region: PRK08507 484022002365 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 484022002366 phosphate binding site [ion binding]; other site 484022002367 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 484022002368 active site 484022002369 dimer interface [polypeptide binding]; other site 484022002370 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 484022002371 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 484022002372 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 484022002373 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 484022002374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 484022002375 Chorismate mutase type II; Region: CM_2; cl00693 484022002376 SOUL heme-binding protein; Region: SOUL; pfam04832 484022002377 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484022002378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484022002379 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484022002380 dimerization interface [polypeptide binding]; other site 484022002381 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 484022002382 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 484022002383 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484022002384 HlyD family secretion protein; Region: HlyD_3; pfam13437 484022002385 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002386 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022002387 Integrase core domain; Region: rve; pfam00665 484022002388 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 484022002389 active site 484022002390 catalytic triad [active] 484022002391 oxyanion hole [active] 484022002392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 484022002393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484022002394 ATP binding site [chemical binding]; other site 484022002395 G-X-G motif; other site 484022002396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484022002397 Response regulator receiver domain; Region: Response_reg; pfam00072 484022002398 active site 484022002399 phosphorylation site [posttranslational modification] 484022002400 intermolecular recognition site; other site 484022002401 dimerization interface [polypeptide binding]; other site 484022002402 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022002403 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002404 Integrase core domain; Region: rve; pfam00665 484022002405 Integrase core domain; Region: rve_3; cl15866 484022002406 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 484022002407 mannose binding site [chemical binding]; other site 484022002408 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 484022002409 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 484022002410 dihydroorotase; Reviewed; Region: PRK09236 484022002411 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 484022002412 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 484022002413 active site 484022002414 thiopurine S-methyltransferase; Reviewed; Region: PRK13256 484022002415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022002416 S-adenosylmethionine binding site [chemical binding]; other site 484022002417 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 484022002418 catalytic core [active] 484022002419 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 484022002420 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 484022002421 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 484022002422 catalytic site [active] 484022002423 subunit interface [polypeptide binding]; other site 484022002424 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 484022002425 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 484022002426 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 484022002427 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 484022002428 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 484022002429 ATP-grasp domain; Region: ATP-grasp_4; cl17255 484022002430 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 484022002431 substrate binding site [chemical binding]; other site 484022002432 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 484022002433 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 484022002434 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 484022002435 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 484022002436 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 484022002437 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002438 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022002439 Integrase core domain; Region: rve; pfam00665 484022002440 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 484022002441 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 484022002442 catalytic triad [active] 484022002443 Acylphosphatase; Region: Acylphosphatase; pfam00708 484022002444 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 484022002445 HypF finger; Region: zf-HYPF; pfam07503 484022002446 HypF finger; Region: zf-HYPF; pfam07503 484022002447 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 484022002448 HupF/HypC family; Region: HupF_HypC; pfam01455 484022002449 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 484022002450 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 484022002451 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 484022002452 dimerization interface [polypeptide binding]; other site 484022002453 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 484022002454 ATP binding site [chemical binding]; other site 484022002455 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 484022002456 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 484022002457 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 484022002458 FAD binding pocket [chemical binding]; other site 484022002459 FAD binding motif [chemical binding]; other site 484022002460 phosphate binding motif [ion binding]; other site 484022002461 beta-alpha-beta structure motif; other site 484022002462 NAD binding pocket [chemical binding]; other site 484022002463 Iron coordination center [ion binding]; other site 484022002464 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 484022002465 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 484022002466 High-affinity nickel-transport protein; Region: NicO; cl00964 484022002467 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 484022002468 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 484022002469 nickel binding site [ion binding]; other site 484022002470 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 484022002471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484022002472 Walker A/P-loop; other site 484022002473 ATP binding site [chemical binding]; other site 484022002474 Q-loop/lid; other site 484022002475 ABC transporter signature motif; other site 484022002476 Walker B; other site 484022002477 D-loop; other site 484022002478 H-loop/switch region; other site 484022002479 ABC transporter; Region: ABC_tran_2; pfam12848 484022002480 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484022002481 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022002482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 484022002483 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 484022002484 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 484022002485 Ureide permease; Region: Ureide_permease; pfam07168 484022002486 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 484022002487 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484022002488 substrate binding site [chemical binding]; other site 484022002489 dimer interface [polypeptide binding]; other site 484022002490 ATP binding site [chemical binding]; other site 484022002491 Protein of unknown function (DUF497); Region: DUF497; cl01108 484022002492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 484022002493 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 484022002494 aminopeptidase N; Provisional; Region: pepN; PRK14015 484022002495 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 484022002496 active site 484022002497 Zn binding site [ion binding]; other site 484022002498 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 484022002499 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 484022002500 active site 484022002501 ribulose/triose binding site [chemical binding]; other site 484022002502 phosphate binding site [ion binding]; other site 484022002503 substrate (anthranilate) binding pocket [chemical binding]; other site 484022002504 product (indole) binding pocket [chemical binding]; other site 484022002505 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 484022002506 active site 484022002507 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 484022002508 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 484022002509 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 484022002510 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 484022002511 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 484022002512 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 484022002513 Glutamine amidotransferase class-I; Region: GATase; pfam00117 484022002514 glutamine binding [chemical binding]; other site 484022002515 catalytic triad [active] 484022002516 anthranilate synthase component I; Provisional; Region: PRK13564 484022002517 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 484022002518 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 484022002519 Trp repressor protein; Region: Trp_repressor; cl17266 484022002520 ribonuclease G; Provisional; Region: PRK11712 484022002521 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 484022002522 homodimer interface [polypeptide binding]; other site 484022002523 oligonucleotide binding site [chemical binding]; other site 484022002524 DnaA N-terminal domain; Region: DnaA_N; pfam11638 484022002525 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 484022002526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484022002527 Walker A motif; other site 484022002528 ATP binding site [chemical binding]; other site 484022002529 Walker B motif; other site 484022002530 arginine finger; other site 484022002531 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 484022002532 DnaA box-binding interface [nucleotide binding]; other site 484022002533 DNA polymerase III subunit beta; Validated; Region: PRK05643 484022002534 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 484022002535 putative DNA binding surface [nucleotide binding]; other site 484022002536 dimer interface [polypeptide binding]; other site 484022002537 beta-clamp/clamp loader binding surface; other site 484022002538 beta-clamp/translesion DNA polymerase binding surface; other site 484022002539 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484022002540 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 484022002541 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002542 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022002543 Integrase core domain; Region: rve; pfam00665 484022002544 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 484022002545 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 484022002546 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 484022002547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002548 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022002549 putative substrate translocation pore; other site 484022002550 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 484022002551 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 484022002552 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 484022002553 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002554 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022002555 Integrase core domain; Region: rve; pfam00665 484022002556 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 484022002557 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 484022002558 hydrophobic ligand binding site; other site 484022002559 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002560 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022002561 Integrase core domain; Region: rve; pfam00665 484022002562 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 484022002563 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 484022002564 [2Fe-2S] cluster binding site [ion binding]; other site 484022002565 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854 484022002566 hypothetical protein; Provisional; Region: PRK05421 484022002567 putative catalytic site [active] 484022002568 putative metal binding site [ion binding]; other site 484022002569 putative phosphate binding site [ion binding]; other site 484022002570 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 484022002571 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 484022002572 putative acyl-acceptor binding pocket; other site 484022002573 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 484022002574 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 484022002575 putative acyl-acceptor binding pocket; other site 484022002576 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 484022002577 4Fe-4S binding domain; Region: Fer4; cl02805 484022002578 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 484022002579 Frag1/DRAM/Sfk1 family; Region: Frag1; pfam10277 484022002580 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 484022002581 ATP-grasp domain; Region: ATP-grasp; pfam02222 484022002582 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 484022002583 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 484022002584 active site 484022002585 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 484022002586 Clp amino terminal domain; Region: Clp_N; pfam02861 484022002587 Clp amino terminal domain; Region: Clp_N; pfam02861 484022002588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484022002589 Walker A motif; other site 484022002590 ATP binding site [chemical binding]; other site 484022002591 Walker B motif; other site 484022002592 arginine finger; other site 484022002593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484022002594 Walker A motif; other site 484022002595 ATP binding site [chemical binding]; other site 484022002596 Walker B motif; other site 484022002597 arginine finger; other site 484022002598 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 484022002599 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 484022002600 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 484022002601 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 484022002602 substrate binding site [chemical binding]; other site 484022002603 active site 484022002604 catalytic residues [active] 484022002605 heterodimer interface [polypeptide binding]; other site 484022002606 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 484022002607 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 484022002608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022002609 catalytic residue [active] 484022002610 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 484022002611 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 484022002612 active site 484022002613 Zn binding site [ion binding]; other site 484022002614 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 484022002615 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 484022002616 Cl- selectivity filter; other site 484022002617 Cl- binding residues [ion binding]; other site 484022002618 pore gating glutamate residue; other site 484022002619 dimer interface [polypeptide binding]; other site 484022002620 H+/Cl- coupling transport residue; other site 484022002621 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 484022002622 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 484022002623 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 484022002624 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 484022002625 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 484022002626 active site 484022002627 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 484022002628 aspartate kinase III; Validated; Region: PRK09084 484022002629 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 484022002630 nucleotide binding site [chemical binding]; other site 484022002631 substrate binding site [chemical binding]; other site 484022002632 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 484022002633 lysine allosteric regulatory site; other site 484022002634 dimer interface [polypeptide binding]; other site 484022002635 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 484022002636 dihydrodipicolinate reductase; Provisional; Region: PRK00048 484022002637 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 484022002638 Peptidase family C1 propeptide; Region: Propeptide_C1; pfam08127 484022002639 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 484022002640 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 484022002641 dihydrodipicolinate synthase; Region: dapA; TIGR00674 484022002642 dimer interface [polypeptide binding]; other site 484022002643 active site 484022002644 catalytic residue [active] 484022002645 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 484022002646 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 484022002647 trimer interface [polypeptide binding]; other site 484022002648 active site 484022002649 substrate binding site [chemical binding]; other site 484022002650 CoA binding site [chemical binding]; other site 484022002651 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 484022002652 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810 484022002653 dimer interface [polypeptide binding]; other site 484022002654 active site 484022002655 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484022002656 catalytic residues [active] 484022002657 substrate binding site [chemical binding]; other site 484022002658 aspartate aminotransferase; Provisional; Region: PRK05764 484022002659 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484022002660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022002661 homodimer interface [polypeptide binding]; other site 484022002662 catalytic residue [active] 484022002663 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 484022002664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002665 putative substrate translocation pore; other site 484022002666 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 484022002667 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 484022002668 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 484022002669 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484022002670 Soluble P-type ATPase [General function prediction only]; Region: COG4087 484022002671 K+-transporting ATPase, c chain; Region: KdpC; cl00944 484022002672 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 484022002673 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 484022002674 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 484022002675 Ligand Binding Site [chemical binding]; other site 484022002676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484022002677 dimer interface [polypeptide binding]; other site 484022002678 phosphorylation site [posttranslational modification] 484022002679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484022002680 ATP binding site [chemical binding]; other site 484022002681 Mg2+ binding site [ion binding]; other site 484022002682 G-X-G motif; other site 484022002683 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484022002684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484022002685 active site 484022002686 phosphorylation site [posttranslational modification] 484022002687 intermolecular recognition site; other site 484022002688 dimerization interface [polypeptide binding]; other site 484022002689 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484022002690 DNA binding site [nucleotide binding] 484022002691 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 484022002692 aromatic amino acid transport protein; Region: araaP; TIGR00837 484022002693 GTPase CgtA; Reviewed; Region: obgE; PRK12299 484022002694 GTP1/OBG; Region: GTP1_OBG; pfam01018 484022002695 Obg GTPase; Region: Obg; cd01898 484022002696 G1 box; other site 484022002697 GTP/Mg2+ binding site [chemical binding]; other site 484022002698 Switch I region; other site 484022002699 G2 box; other site 484022002700 G3 box; other site 484022002701 Switch II region; other site 484022002702 G4 box; other site 484022002703 G5 box; other site 484022002704 Amino acid permease; Region: AA_permease_2; pfam13520 484022002705 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 484022002706 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 484022002707 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 484022002708 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 484022002709 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 484022002710 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 484022002711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002712 putative substrate translocation pore; other site 484022002713 putative protease; Provisional; Region: PRK15452 484022002714 Peptidase family U32; Region: Peptidase_U32; pfam01136 484022002715 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 484022002716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 484022002717 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 484022002718 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 484022002719 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 484022002720 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 484022002721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022002722 catalytic residue [active] 484022002723 amidophosphoribosyltransferase; Provisional; Region: PRK09246 484022002724 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 484022002725 active site 484022002726 tetramer interface [polypeptide binding]; other site 484022002727 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484022002728 active site 484022002729 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 484022002730 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 484022002731 dimerization interface [polypeptide binding]; other site 484022002732 ATP binding site [chemical binding]; other site 484022002733 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 484022002734 dimerization interface [polypeptide binding]; other site 484022002735 ATP binding site [chemical binding]; other site 484022002736 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 484022002737 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 484022002738 putative active site [active] 484022002739 catalytic triad [active] 484022002740 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002741 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022002742 Integrase core domain; Region: rve; pfam00665 484022002743 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 484022002744 active site 484022002745 catalytic residues [active] 484022002746 adenylosuccinate lyase; Provisional; Region: PRK07492 484022002747 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 484022002748 tetramer interface [polypeptide binding]; other site 484022002749 active site 484022002750 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484022002751 E3 interaction surface; other site 484022002752 lipoyl attachment site [posttranslational modification]; other site 484022002753 HlyD family secretion protein; Region: HlyD_3; pfam13437 484022002754 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 484022002755 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 484022002756 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 484022002757 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 484022002758 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 484022002759 GatB domain; Region: GatB_Yqey; smart00845 484022002760 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 484022002761 active site 484022002762 oxyanion hole [active] 484022002763 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 484022002764 catalytic triad [active] 484022002765 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 484022002766 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 484022002767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002768 putative substrate translocation pore; other site 484022002769 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 484022002770 IucA / IucC family; Region: IucA_IucC; pfam04183 484022002771 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 484022002772 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 484022002773 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 484022002774 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 484022002775 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484022002776 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 484022002777 IucA / IucC family; Region: IucA_IucC; pfam04183 484022002778 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 484022002779 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 484022002780 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022002781 catalytic residue [active] 484022002782 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 484022002783 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484022002784 inhibitor-cofactor binding pocket; inhibition site 484022002785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022002786 catalytic residue [active] 484022002787 aspartate kinase III; Validated; Region: PRK09084 484022002788 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 484022002789 nucleotide binding site [chemical binding]; other site 484022002790 substrate binding site [chemical binding]; other site 484022002791 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 484022002792 metal binding site 2 [ion binding]; metal-binding site 484022002793 putative DNA binding helix; other site 484022002794 metal binding site 1 [ion binding]; metal-binding site 484022002795 dimer interface [polypeptide binding]; other site 484022002796 structural Zn2+ binding site [ion binding]; other site 484022002797 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 484022002798 NADH dehydrogenase subunit B; Validated; Region: PRK06411 484022002799 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 484022002800 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 484022002801 NADH dehydrogenase subunit D; Validated; Region: PRK06075 484022002802 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 484022002803 NADH dehydrogenase subunit E; Validated; Region: PRK07539 484022002804 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 484022002805 putative dimer interface [polypeptide binding]; other site 484022002806 [2Fe-2S] cluster binding site [ion binding]; other site 484022002807 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 484022002808 SLBB domain; Region: SLBB; pfam10531 484022002809 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 484022002810 NADH dehydrogenase subunit G; Validated; Region: PRK09129 484022002811 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 484022002812 catalytic loop [active] 484022002813 iron binding site [ion binding]; other site 484022002814 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 484022002815 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 484022002816 molybdopterin cofactor binding site; other site 484022002817 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 484022002818 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 484022002819 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 484022002820 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 484022002821 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 484022002822 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 484022002823 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 484022002824 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 484022002825 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 484022002826 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 484022002827 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 484022002828 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 484022002829 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 484022002830 Membrane fusogenic activity; Region: BMFP; pfam04380 484022002831 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 484022002832 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 484022002833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484022002834 Walker A motif; other site 484022002835 ATP binding site [chemical binding]; other site 484022002836 Walker B motif; other site 484022002837 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 484022002838 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 484022002839 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 484022002840 substrate binding site [chemical binding]; other site 484022002841 active site 484022002842 ribosome maturation protein RimP; Reviewed; Region: PRK00092 484022002843 Sm and related proteins; Region: Sm_like; cl00259 484022002844 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 484022002845 putative oligomer interface [polypeptide binding]; other site 484022002846 putative RNA binding site [nucleotide binding]; other site 484022002847 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 484022002848 NusA N-terminal domain; Region: NusA_N; pfam08529 484022002849 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 484022002850 RNA binding site [nucleotide binding]; other site 484022002851 homodimer interface [polypeptide binding]; other site 484022002852 NusA-like KH domain; Region: KH_5; pfam13184 484022002853 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 484022002854 G-X-X-G motif; other site 484022002855 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 484022002856 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 484022002857 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 484022002858 translation initiation factor IF-2; Region: IF-2; TIGR00487 484022002859 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 484022002860 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 484022002861 G1 box; other site 484022002862 putative GEF interaction site [polypeptide binding]; other site 484022002863 GTP/Mg2+ binding site [chemical binding]; other site 484022002864 Switch I region; other site 484022002865 G2 box; other site 484022002866 G3 box; other site 484022002867 Switch II region; other site 484022002868 G4 box; other site 484022002869 G5 box; other site 484022002870 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 484022002871 Translation-initiation factor 2; Region: IF-2; pfam11987 484022002872 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 484022002873 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 484022002874 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 484022002875 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 484022002876 dimer interface [polypeptide binding]; other site 484022002877 motif 1; other site 484022002878 active site 484022002879 motif 2; other site 484022002880 motif 3; other site 484022002881 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 484022002882 anticodon binding site; other site 484022002883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002884 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 484022002885 putative substrate translocation pore; other site 484022002886 Predicted ATPase [General function prediction only]; Region: COG1485 484022002887 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 484022002888 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484022002889 RNA binding surface [nucleotide binding]; other site 484022002890 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 484022002891 active site 484022002892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022002893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022002894 putative substrate translocation pore; other site 484022002895 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 484022002896 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 484022002897 F0F1 ATP synthase subunit C; Provisional; Region: PRK13464 484022002898 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 484022002899 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 484022002900 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 484022002901 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 484022002902 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 484022002903 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 484022002904 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 484022002905 beta subunit interaction interface [polypeptide binding]; other site 484022002906 Walker A motif; other site 484022002907 ATP binding site [chemical binding]; other site 484022002908 Walker B motif; other site 484022002909 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 484022002910 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 484022002911 core domain interface [polypeptide binding]; other site 484022002912 delta subunit interface [polypeptide binding]; other site 484022002913 epsilon subunit interface [polypeptide binding]; other site 484022002914 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 484022002915 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 484022002916 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 484022002917 alpha subunit interaction interface [polypeptide binding]; other site 484022002918 Walker A motif; other site 484022002919 ATP binding site [chemical binding]; other site 484022002920 Walker B motif; other site 484022002921 inhibitor binding site; inhibition site 484022002922 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 484022002923 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 484022002924 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 484022002925 gamma subunit interface [polypeptide binding]; other site 484022002926 epsilon subunit interface [polypeptide binding]; other site 484022002927 LBP interface [polypeptide binding]; other site 484022002928 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 484022002929 active site 484022002930 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 484022002931 putative active site [active] 484022002932 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 484022002933 putative GSH binding site [chemical binding]; other site 484022002934 catalytic residues [active] 484022002935 superoxide dismutase; Provisional; Region: PRK10543 484022002936 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 484022002937 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 484022002938 muropeptide transporter; Validated; Region: ampG; cl17669 484022002939 muropeptide transporter; Reviewed; Region: ampG; PRK11902 484022002940 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 484022002941 dimer interface [polypeptide binding]; other site 484022002942 Citrate synthase; Region: Citrate_synt; pfam00285 484022002943 active site 484022002944 citrylCoA binding site [chemical binding]; other site 484022002945 NADH binding [chemical binding]; other site 484022002946 cationic pore residues; other site 484022002947 oxalacetate/citrate binding site [chemical binding]; other site 484022002948 coenzyme A binding site [chemical binding]; other site 484022002949 catalytic triad [active] 484022002950 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 484022002951 Iron-sulfur protein interface; other site 484022002952 proximal quinone binding site [chemical binding]; other site 484022002953 SdhD (CybS) interface [polypeptide binding]; other site 484022002954 proximal heme binding site [chemical binding]; other site 484022002955 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 484022002956 SdhC subunit interface [polypeptide binding]; other site 484022002957 proximal heme binding site [chemical binding]; other site 484022002958 cardiolipin binding site; other site 484022002959 Iron-sulfur protein interface; other site 484022002960 proximal quinone binding site [chemical binding]; other site 484022002961 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 484022002962 L-aspartate oxidase; Provisional; Region: PRK06175 484022002963 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 484022002964 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 484022002965 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 484022002966 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 484022002967 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 484022002968 TPP-binding site [chemical binding]; other site 484022002969 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 484022002970 PYR/PP interface [polypeptide binding]; other site 484022002971 dimer interface [polypeptide binding]; other site 484022002972 TPP binding site [chemical binding]; other site 484022002973 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484022002974 E3 interaction surface; other site 484022002975 lipoyl attachment site [posttranslational modification]; other site 484022002976 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 484022002977 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484022002978 E3 interaction surface; other site 484022002979 lipoyl attachment site [posttranslational modification]; other site 484022002980 e3 binding domain; Region: E3_binding; pfam02817 484022002981 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 484022002982 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484022002983 active site 484022002984 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 484022002985 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 484022002986 active site 484022002987 substrate binding site [chemical binding]; other site 484022002988 metal binding site [ion binding]; metal-binding site 484022002989 triosephosphate isomerase; Provisional; Region: PRK14567 484022002990 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 484022002991 substrate binding site [chemical binding]; other site 484022002992 dimer interface [polypeptide binding]; other site 484022002993 catalytic triad [active] 484022002994 Preprotein translocase SecG subunit; Region: SecG; pfam03840 484022002995 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022002996 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022002997 Integrase core domain; Region: rve; pfam00665 484022002998 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 484022002999 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 484022003000 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 484022003001 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022003002 Integrase core domain; Region: rve; pfam00665 484022003003 Integrase core domain; Region: rve_3; cl15866 484022003004 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022003005 Terminase small subunit; Region: Terminase_2; cl01513 484022003006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484022003007 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022003008 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022003009 Integrase core domain; Region: rve; pfam00665 484022003010 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484022003011 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484022003012 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 484022003013 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 484022003014 HemN family oxidoreductase; Provisional; Region: PRK05660 484022003015 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484022003016 FeS/SAM binding site; other site 484022003017 HemN C-terminal domain; Region: HemN_C; pfam06969 484022003018 GtrA-like protein; Region: GtrA; pfam04138 484022003019 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 484022003020 aconitate hydratase; Validated; Region: PRK09277 484022003021 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 484022003022 substrate binding site [chemical binding]; other site 484022003023 ligand binding site [chemical binding]; other site 484022003024 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 484022003025 substrate binding site [chemical binding]; other site 484022003026 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 484022003027 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 484022003028 Walker A motif; other site 484022003029 ATP binding site [chemical binding]; other site 484022003030 Walker B motif; other site 484022003031 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 484022003032 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 484022003033 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 484022003034 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 484022003035 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 484022003036 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 484022003037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003038 TIGR01777 family protein; Region: yfcH 484022003039 NAD(P) binding site [chemical binding]; other site 484022003040 active site 484022003041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 484022003042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484022003043 dimer interface [polypeptide binding]; other site 484022003044 phosphorylation site [posttranslational modification] 484022003045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484022003046 ATP binding site [chemical binding]; other site 484022003047 Mg2+ binding site [ion binding]; other site 484022003048 G-X-G motif; other site 484022003049 ATP-grasp domain; Region: ATP-grasp_4; cl17255 484022003050 Protein of unknown function (DUF523); Region: DUF523; pfam04463 484022003051 Uncharacterized conserved protein [Function unknown]; Region: COG3272 484022003052 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 484022003053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003054 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 484022003055 putative substrate translocation pore; other site 484022003056 multidrug efflux protein; Reviewed; Region: PRK09579 484022003057 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 484022003058 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484022003059 HlyD family secretion protein; Region: HlyD_3; pfam13437 484022003060 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 484022003061 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 484022003062 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 484022003063 active site 484022003064 NTP binding site [chemical binding]; other site 484022003065 metal binding triad [ion binding]; metal-binding site 484022003066 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 484022003067 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 484022003068 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484022003069 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 484022003070 Walker A/P-loop; other site 484022003071 ATP binding site [chemical binding]; other site 484022003072 Q-loop/lid; other site 484022003073 ABC transporter signature motif; other site 484022003074 Walker B; other site 484022003075 D-loop; other site 484022003076 H-loop/switch region; other site 484022003077 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 484022003078 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 484022003079 DNA polymerase I; Provisional; Region: PRK05755 484022003080 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 484022003081 active site 484022003082 metal binding site 1 [ion binding]; metal-binding site 484022003083 putative 5' ssDNA interaction site; other site 484022003084 metal binding site 3; metal-binding site 484022003085 metal binding site 2 [ion binding]; metal-binding site 484022003086 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 484022003087 putative DNA binding site [nucleotide binding]; other site 484022003088 putative metal binding site [ion binding]; other site 484022003089 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 484022003090 active site 484022003091 catalytic site [active] 484022003092 substrate binding site [chemical binding]; other site 484022003093 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 484022003094 active site 484022003095 DNA binding site [nucleotide binding] 484022003096 catalytic site [active] 484022003097 pantothenate kinase; Reviewed; Region: PRK13324 484022003098 phosphopentomutase; Provisional; Region: PRK05362 484022003099 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 484022003100 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 484022003101 intersubunit interface [polypeptide binding]; other site 484022003102 active site 484022003103 catalytic residue [active] 484022003104 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 484022003105 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 484022003106 Nucleoside recognition; Region: Gate; pfam07670 484022003107 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 484022003108 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 484022003109 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 484022003110 Nucleoside recognition; Region: Gate; pfam07670 484022003111 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 484022003112 thymidylate kinase; Validated; Region: tmk; PRK00698 484022003113 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 484022003114 TMP-binding site; other site 484022003115 ATP-binding site [chemical binding]; other site 484022003116 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 484022003117 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 484022003118 G1 box; other site 484022003119 putative GEF interaction site [polypeptide binding]; other site 484022003120 GTP/Mg2+ binding site [chemical binding]; other site 484022003121 Switch I region; other site 484022003122 G2 box; other site 484022003123 G3 box; other site 484022003124 Switch II region; other site 484022003125 G4 box; other site 484022003126 G5 box; other site 484022003127 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 484022003128 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 484022003129 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 484022003130 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 484022003131 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 484022003132 P loop; other site 484022003133 GTP binding site [chemical binding]; other site 484022003134 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 484022003135 Part of AAA domain; Region: AAA_19; pfam13245 484022003136 Family description; Region: UvrD_C_2; pfam13538 484022003137 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 484022003138 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 484022003139 peptide binding site [polypeptide binding]; other site 484022003140 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 484022003141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484022003142 dimer interface [polypeptide binding]; other site 484022003143 conserved gate region; other site 484022003144 putative PBP binding loops; other site 484022003145 ABC-ATPase subunit interface; other site 484022003146 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 484022003147 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 484022003148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484022003149 dimer interface [polypeptide binding]; other site 484022003150 conserved gate region; other site 484022003151 putative PBP binding loops; other site 484022003152 ABC-ATPase subunit interface; other site 484022003153 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 484022003154 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484022003155 Walker A/P-loop; other site 484022003156 ATP binding site [chemical binding]; other site 484022003157 Q-loop/lid; other site 484022003158 ABC transporter signature motif; other site 484022003159 Walker B; other site 484022003160 D-loop; other site 484022003161 H-loop/switch region; other site 484022003162 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484022003163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003164 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022003165 putative substrate translocation pore; other site 484022003166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003167 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022003168 putative substrate translocation pore; other site 484022003169 glycerol kinase; Provisional; Region: glpK; PRK00047 484022003170 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 484022003171 N- and C-terminal domain interface [polypeptide binding]; other site 484022003172 active site 484022003173 MgATP binding site [chemical binding]; other site 484022003174 catalytic site [active] 484022003175 metal binding site [ion binding]; metal-binding site 484022003176 glycerol binding site [chemical binding]; other site 484022003177 homotetramer interface [polypeptide binding]; other site 484022003178 homodimer interface [polypeptide binding]; other site 484022003179 FBP binding site [chemical binding]; other site 484022003180 protein IIAGlc interface [polypeptide binding]; other site 484022003181 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 484022003182 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 484022003183 amphipathic channel; other site 484022003184 Asn-Pro-Ala signature motifs; other site 484022003185 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 484022003186 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484022003187 AAA domain; Region: AAA_30; pfam13604 484022003188 Family description; Region: UvrD_C_2; pfam13538 484022003189 elongation factor Tu; Reviewed; Region: PRK00049 484022003190 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 484022003191 G1 box; other site 484022003192 GEF interaction site [polypeptide binding]; other site 484022003193 GTP/Mg2+ binding site [chemical binding]; other site 484022003194 Switch I region; other site 484022003195 G2 box; other site 484022003196 G3 box; other site 484022003197 Switch II region; other site 484022003198 G4 box; other site 484022003199 G5 box; other site 484022003200 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 484022003201 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 484022003202 Antibiotic Binding Site [chemical binding]; other site 484022003203 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 484022003204 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 484022003205 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 484022003206 putative homodimer interface [polypeptide binding]; other site 484022003207 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 484022003208 heterodimer interface [polypeptide binding]; other site 484022003209 homodimer interface [polypeptide binding]; other site 484022003210 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 484022003211 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 484022003212 23S rRNA interface [nucleotide binding]; other site 484022003213 L7/L12 interface [polypeptide binding]; other site 484022003214 putative thiostrepton binding site; other site 484022003215 L25 interface [polypeptide binding]; other site 484022003216 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 484022003217 mRNA/rRNA interface [nucleotide binding]; other site 484022003218 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 484022003219 23S rRNA interface [nucleotide binding]; other site 484022003220 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 484022003221 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 484022003222 core dimer interface [polypeptide binding]; other site 484022003223 peripheral dimer interface [polypeptide binding]; other site 484022003224 L10 interface [polypeptide binding]; other site 484022003225 L11 interface [polypeptide binding]; other site 484022003226 putative EF-Tu interaction site [polypeptide binding]; other site 484022003227 putative EF-G interaction site [polypeptide binding]; other site 484022003228 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 484022003229 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 484022003230 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 484022003231 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 484022003232 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 484022003233 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 484022003234 RPB3 interaction site [polypeptide binding]; other site 484022003235 RPB1 interaction site [polypeptide binding]; other site 484022003236 RPB11 interaction site [polypeptide binding]; other site 484022003237 RPB10 interaction site [polypeptide binding]; other site 484022003238 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 484022003239 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 484022003240 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 484022003241 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 484022003242 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 484022003243 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 484022003244 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 484022003245 cleft; other site 484022003246 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 484022003247 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 484022003248 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 484022003249 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 484022003250 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 484022003251 DNA binding site [nucleotide binding] 484022003252 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 484022003253 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 484022003254 UGMP family protein; Validated; Region: PRK09604 484022003255 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 484022003256 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 484022003257 Di-iron ligands [ion binding]; other site 484022003258 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 484022003259 S-adenosylmethionine synthetase; Validated; Region: PRK05250 484022003260 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 484022003261 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 484022003262 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 484022003263 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 484022003264 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 484022003265 RimM N-terminal domain; Region: RimM; pfam01782 484022003266 PRC-barrel domain; Region: PRC; pfam05239 484022003267 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 484022003268 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 484022003269 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 484022003270 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 484022003271 active site 484022003272 DNA binding site [nucleotide binding] 484022003273 Int/Topo IB signature motif; other site 484022003274 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 484022003275 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 484022003276 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 484022003277 Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476 484022003278 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 484022003279 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 484022003280 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 484022003281 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 484022003282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003283 NAD(P) binding site [chemical binding]; other site 484022003284 active site 484022003285 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 484022003286 AMP-binding enzyme; Region: AMP-binding; pfam00501 484022003287 acyl-activating enzyme (AAE) consensus motif; other site 484022003288 AMP binding site [chemical binding]; other site 484022003289 active site 484022003290 CoA binding site [chemical binding]; other site 484022003291 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 484022003292 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 484022003293 putative NAD(P) binding site [chemical binding]; other site 484022003294 active site 484022003295 putative substrate binding site [chemical binding]; other site 484022003296 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 484022003297 putative active site [active] 484022003298 Ap4A binding site [chemical binding]; other site 484022003299 nudix motif; other site 484022003300 putative metal binding site [ion binding]; other site 484022003301 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 484022003302 active site 484022003303 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 484022003304 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 484022003305 amidase catalytic site [active] 484022003306 Zn binding residues [ion binding]; other site 484022003307 substrate binding site [chemical binding]; other site 484022003308 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 484022003309 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 484022003310 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 484022003311 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 484022003312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484022003313 Mg2+ binding site [ion binding]; other site 484022003314 G-X-G motif; other site 484022003315 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 484022003316 anchoring element; other site 484022003317 dimer interface [polypeptide binding]; other site 484022003318 ATP binding site [chemical binding]; other site 484022003319 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 484022003320 active site 484022003321 metal binding site [ion binding]; metal-binding site 484022003322 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 484022003323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003324 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 484022003325 putative substrate translocation pore; other site 484022003326 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 484022003327 Trp docking motif [polypeptide binding]; other site 484022003328 PQQ-like domain; Region: PQQ_2; pfam13360 484022003329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 484022003330 TPR motif; other site 484022003331 binding surface 484022003332 Tetratricopeptide repeat; Region: TPR_16; pfam13432 484022003333 glutamyl-tRNA reductase; Provisional; Region: PRK13940 484022003334 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 484022003335 tRNA; other site 484022003336 putative tRNA binding site [nucleotide binding]; other site 484022003337 putative NADP binding site [chemical binding]; other site 484022003338 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 484022003339 peptide chain release factor 1; Validated; Region: prfA; PRK00591 484022003340 This domain is found in peptide chain release factors; Region: PCRF; smart00937 484022003341 RF-1 domain; Region: RF-1; pfam00472 484022003342 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 484022003343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022003344 S-adenosylmethionine binding site [chemical binding]; other site 484022003345 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 484022003346 hypothetical protein; Validated; Region: PRK02101 484022003347 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 484022003348 Predicted exporter [General function prediction only]; Region: COG4258 484022003349 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 484022003350 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 484022003351 active site 484022003352 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 484022003353 putative acyl-acceptor binding pocket; other site 484022003354 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 484022003355 Ligand binding site; other site 484022003356 Putative Catalytic site; other site 484022003357 DXD motif; other site 484022003358 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 484022003359 active site 2 [active] 484022003360 active site 1 [active] 484022003361 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 484022003362 acyl-activating enzyme (AAE) consensus motif; other site 484022003363 AMP binding site [chemical binding]; other site 484022003364 active site 484022003365 CoA binding site [chemical binding]; other site 484022003366 Predicted membrane protein [Function unknown]; Region: COG4648 484022003367 acyl carrier protein; Provisional; Region: PRK05350 484022003368 Phosphopantetheine attachment site; Region: PP-binding; cl09936 484022003369 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 484022003370 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 484022003371 putative acyl-acceptor binding pocket; other site 484022003372 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 484022003373 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 484022003374 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 484022003375 dimer interface [polypeptide binding]; other site 484022003376 active site 484022003377 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 484022003378 active site 2 [active] 484022003379 active site 1 [active] 484022003380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003381 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 484022003382 NAD(P) binding site [chemical binding]; other site 484022003383 active site 484022003384 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 484022003385 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 484022003386 dimer interface [polypeptide binding]; other site 484022003387 active site 484022003388 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 484022003389 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 484022003390 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 484022003391 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 484022003392 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 484022003393 G1 box; other site 484022003394 GTP/Mg2+ binding site [chemical binding]; other site 484022003395 Switch I region; other site 484022003396 G2 box; other site 484022003397 G3 box; other site 484022003398 Switch II region; other site 484022003399 G4 box; other site 484022003400 G5 box; other site 484022003401 Nucleoside recognition; Region: Gate; pfam07670 484022003402 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 484022003403 Nucleoside recognition; Region: Gate; pfam07670 484022003404 FeoA domain; Region: FeoA; cl00838 484022003405 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 484022003406 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 484022003407 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 484022003408 oligomerisation interface [polypeptide binding]; other site 484022003409 mobile loop; other site 484022003410 roof hairpin; other site 484022003411 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 484022003412 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 484022003413 ring oligomerisation interface [polypeptide binding]; other site 484022003414 ATP/Mg binding site [chemical binding]; other site 484022003415 stacking interactions; other site 484022003416 hinge regions; other site 484022003417 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 484022003418 short chain dehydrogenase; Provisional; Region: PRK05993 484022003419 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 484022003420 NADP binding site [chemical binding]; other site 484022003421 active site 484022003422 steroid binding site; other site 484022003423 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 484022003424 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 484022003425 active site 484022003426 catalytic residues [active] 484022003427 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 484022003428 DNA-binding interface [nucleotide binding]; DNA binding site 484022003429 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 484022003430 HI0933-like protein; Region: HI0933_like; pfam03486 484022003431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003432 putative substrate translocation pore; other site 484022003433 glutamate dehydrogenase; Provisional; Region: PRK09414 484022003434 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 484022003435 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 484022003436 NAD(P) binding pocket [chemical binding]; other site 484022003437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 484022003438 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 484022003439 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 484022003440 active site 484022003441 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484022003442 substrate binding site [chemical binding]; other site 484022003443 catalytic residues [active] 484022003444 dimer interface [polypeptide binding]; other site 484022003445 Amino acid permease; Region: AA_permease_2; pfam13520 484022003446 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 484022003447 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 484022003448 DNA binding site [nucleotide binding] 484022003449 active site 484022003450 Uncharacterized conserved protein [Function unknown]; Region: COG0398 484022003451 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 484022003452 mercuric reductase; Validated; Region: PRK06370 484022003453 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484022003454 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484022003455 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484022003456 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 484022003457 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 484022003458 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 484022003459 HSP70 interaction site [polypeptide binding]; other site 484022003460 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 484022003461 substrate binding site [polypeptide binding]; other site 484022003462 dimer interface [polypeptide binding]; other site 484022003463 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022003464 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022003465 Integrase core domain; Region: rve; pfam00665 484022003466 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 484022003467 EamA-like transporter family; Region: EamA; pfam00892 484022003468 EamA-like transporter family; Region: EamA; pfam00892 484022003469 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 484022003470 aromatic amino acid transport protein; Region: araaP; TIGR00837 484022003471 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 484022003472 HD domain; Region: HD_4; pfam13328 484022003473 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 484022003474 synthetase active site [active] 484022003475 NTP binding site [chemical binding]; other site 484022003476 metal binding site [ion binding]; metal-binding site 484022003477 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 484022003478 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 484022003479 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 484022003480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022003481 S-adenosylmethionine binding site [chemical binding]; other site 484022003482 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 484022003483 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 484022003484 active site 484022003485 DNA binding site [nucleotide binding] 484022003486 Int/Topo IB signature motif; other site 484022003487 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 484022003488 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 484022003489 preprotein translocase subunit SecB; Validated; Region: PRK05751 484022003490 SecA binding site; other site 484022003491 Preprotein binding site; other site 484022003492 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 484022003493 MutS domain I; Region: MutS_I; pfam01624 484022003494 MutS domain II; Region: MutS_II; pfam05188 484022003495 MutS domain III; Region: MutS_III; pfam05192 484022003496 MutS domain V; Region: MutS_V; pfam00488 484022003497 Walker A/P-loop; other site 484022003498 ATP binding site [chemical binding]; other site 484022003499 Q-loop/lid; other site 484022003500 ABC transporter signature motif; other site 484022003501 Walker B; other site 484022003502 D-loop; other site 484022003503 H-loop/switch region; other site 484022003504 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 484022003505 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 484022003506 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 484022003507 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 484022003508 putative active site [active] 484022003509 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 484022003510 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 484022003511 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 484022003512 active site 484022003513 HIGH motif; other site 484022003514 dimer interface [polypeptide binding]; other site 484022003515 KMSKS motif; other site 484022003516 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 484022003517 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 484022003518 active site 484022003519 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 484022003520 dephospho-CoA kinase; Region: TIGR00152 484022003521 CoA-binding site [chemical binding]; other site 484022003522 ATP-binding [chemical binding]; other site 484022003523 Uncharacterized conserved protein [Function unknown]; Region: COG1565 484022003524 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 484022003525 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 484022003526 active site 484022003527 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 484022003528 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 484022003529 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 484022003530 Enoylreductase; Region: PKS_ER; smart00829 484022003531 NAD(P) binding site [chemical binding]; other site 484022003532 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 484022003533 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 484022003534 NADP binding site [chemical binding]; other site 484022003535 active site 484022003536 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 484022003537 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 484022003538 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 484022003539 substrate-cofactor binding pocket; other site 484022003540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022003541 catalytic residue [active] 484022003542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 484022003543 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 484022003544 hydrophobic ligand binding site; other site 484022003545 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 484022003546 Cytochrome P450; Region: p450; cl12078 484022003547 Sulfatase; Region: Sulfatase; cl17466 484022003548 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 484022003549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003550 NAD(P) binding site [chemical binding]; other site 484022003551 active site 484022003552 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 484022003553 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 484022003554 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 484022003555 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 484022003556 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 484022003557 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 484022003558 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 484022003559 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 484022003560 Chain length determinant protein; Region: Wzz; cl15801 484022003561 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 484022003562 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 484022003563 Walker A/P-loop; other site 484022003564 ATP binding site [chemical binding]; other site 484022003565 Q-loop/lid; other site 484022003566 ABC transporter signature motif; other site 484022003567 Walker B; other site 484022003568 D-loop; other site 484022003569 H-loop/switch region; other site 484022003570 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 484022003571 ABC-2 type transporter; Region: ABC2_membrane; cl17235 484022003572 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 484022003573 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 484022003574 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 484022003575 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 484022003576 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 484022003577 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 484022003578 NAD(P) binding site [chemical binding]; other site 484022003579 homodimer interface [polypeptide binding]; other site 484022003580 substrate binding site [chemical binding]; other site 484022003581 active site 484022003582 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 484022003583 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 484022003584 inhibitor-cofactor binding pocket; inhibition site 484022003585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022003586 catalytic residue [active] 484022003587 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 484022003588 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 484022003589 putative trimer interface [polypeptide binding]; other site 484022003590 putative CoA binding site [chemical binding]; other site 484022003591 NeuB family; Region: NeuB; pfam03102 484022003592 NeuB family; Region: NeuB; pfam03102 484022003593 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 484022003594 NeuB binding interface [polypeptide binding]; other site 484022003595 putative substrate binding site [chemical binding]; other site 484022003596 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 484022003597 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 484022003598 active site 484022003599 homodimer interface [polypeptide binding]; other site 484022003600 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 484022003601 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 484022003602 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 484022003603 Substrate binding site; other site 484022003604 metal-binding site 484022003605 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 484022003606 ligand binding site; other site 484022003607 tetramer interface; other site 484022003608 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484022003609 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484022003610 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 484022003611 Transposase, Mutator family; Region: Transposase_mut; pfam00872 484022003612 Transposase domain (DUF772); Region: DUF772; pfam05598 484022003613 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 484022003614 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 484022003615 putative ligand binding site [chemical binding]; other site 484022003616 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 484022003617 active site 484022003618 ATP binding site [chemical binding]; other site 484022003619 Phosphotransferase enzyme family; Region: APH; pfam01636 484022003620 substrate binding site [chemical binding]; other site 484022003621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 484022003622 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 484022003623 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 484022003624 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 484022003625 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022003626 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022003627 Integrase core domain; Region: rve; pfam00665 484022003628 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 484022003629 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 484022003630 dimer interface [polypeptide binding]; other site 484022003631 TPP-binding site [chemical binding]; other site 484022003632 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 484022003633 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484022003634 E3 interaction surface; other site 484022003635 lipoyl attachment site [posttranslational modification]; other site 484022003636 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484022003637 E3 interaction surface; other site 484022003638 lipoyl attachment site [posttranslational modification]; other site 484022003639 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484022003640 E3 interaction surface; other site 484022003641 lipoyl attachment site [posttranslational modification]; other site 484022003642 e3 binding domain; Region: E3_binding; pfam02817 484022003643 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 484022003644 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 484022003645 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 484022003646 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484022003647 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484022003648 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 484022003649 ligand binding site [chemical binding]; other site 484022003650 active site 484022003651 UGI interface [polypeptide binding]; other site 484022003652 catalytic site [active] 484022003653 Protein of unknown function (DUF461); Region: DUF461; pfam04314 484022003654 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 484022003655 aromatic chitin/cellulose binding site residues [chemical binding]; other site 484022003656 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022003657 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022003658 Integrase core domain; Region: rve; pfam00665 484022003659 Chitin binding domain; Region: Chitin_bind_3; pfam03067 484022003660 DNA gyrase subunit A; Validated; Region: PRK05560 484022003661 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 484022003662 CAP-like domain; other site 484022003663 active site 484022003664 primary dimer interface [polypeptide binding]; other site 484022003665 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484022003666 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484022003667 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484022003668 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484022003669 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484022003670 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484022003671 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 484022003672 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 484022003673 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 484022003674 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 484022003675 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 484022003676 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484022003677 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484022003678 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484022003679 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484022003680 Surface antigen; Region: Bac_surface_Ag; pfam01103 484022003681 periplasmic chaperone; Provisional; Region: PRK10780 484022003682 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 484022003683 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 484022003684 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 484022003685 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 484022003686 trimer interface [polypeptide binding]; other site 484022003687 active site 484022003688 UDP-GlcNAc binding site [chemical binding]; other site 484022003689 lipid binding site [chemical binding]; lipid-binding site 484022003690 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 484022003691 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 484022003692 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 484022003693 active site 484022003694 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 484022003695 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 484022003696 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 484022003697 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 484022003698 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 484022003699 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 484022003700 substrate binding pocket [chemical binding]; other site 484022003701 chain length determination region; other site 484022003702 substrate-Mg2+ binding site; other site 484022003703 catalytic residues [active] 484022003704 aspartate-rich region 1; other site 484022003705 active site lid residues [active] 484022003706 aspartate-rich region 2; other site 484022003707 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 484022003708 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 484022003709 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484022003710 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 484022003711 active site 484022003712 dimerization interface [polypeptide binding]; other site 484022003713 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 484022003714 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 484022003715 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484022003716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484022003717 active site 484022003718 phosphorylation site [posttranslational modification] 484022003719 intermolecular recognition site; other site 484022003720 dimerization interface [polypeptide binding]; other site 484022003721 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484022003722 DNA binding site [nucleotide binding] 484022003723 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 484022003724 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 484022003725 Catalytic site [active] 484022003726 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 484022003727 ribonuclease III; Reviewed; Region: rnc; PRK00102 484022003728 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 484022003729 dimerization interface [polypeptide binding]; other site 484022003730 active site 484022003731 metal binding site [ion binding]; metal-binding site 484022003732 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 484022003733 dsRNA binding site [nucleotide binding]; other site 484022003734 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 484022003735 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 484022003736 RNA binding site [nucleotide binding]; other site 484022003737 active site 484022003738 ribonuclease R; Region: RNase_R; TIGR02063 484022003739 RNB domain; Region: RNB; pfam00773 484022003740 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 484022003741 RNA binding site [nucleotide binding]; other site 484022003742 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 484022003743 Fatty acid desaturase; Region: FA_desaturase; pfam00487 484022003744 Di-iron ligands [ion binding]; other site 484022003745 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 484022003746 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 484022003747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003748 NAD(P) binding site [chemical binding]; other site 484022003749 active site 484022003750 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 484022003751 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 484022003752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022003753 S-adenosylmethionine binding site [chemical binding]; other site 484022003754 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 484022003755 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 484022003756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 484022003757 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 484022003758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484022003759 dimer interface [polypeptide binding]; other site 484022003760 phosphorylation site [posttranslational modification] 484022003761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484022003762 ATP binding site [chemical binding]; other site 484022003763 Mg2+ binding site [ion binding]; other site 484022003764 G-X-G motif; other site 484022003765 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484022003766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484022003767 active site 484022003768 phosphorylation site [posttranslational modification] 484022003769 intermolecular recognition site; other site 484022003770 dimerization interface [polypeptide binding]; other site 484022003771 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484022003772 DNA binding site [nucleotide binding] 484022003773 Methyltransferase domain; Region: Methyltransf_23; pfam13489 484022003774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022003775 S-adenosylmethionine binding site [chemical binding]; other site 484022003776 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 484022003777 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 484022003778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 484022003779 ornithine cyclodeaminase; Validated; Region: PRK07589 484022003780 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 484022003781 Arginase family; Region: Arginase; cd09989 484022003782 active site 484022003783 Mn binding site [ion binding]; other site 484022003784 oligomer interface [polypeptide binding]; other site 484022003785 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 484022003786 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 484022003787 active site 484022003788 Protein of unknown function (DUF465); Region: DUF465; pfam04325 484022003789 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 484022003790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003791 putative substrate translocation pore; other site 484022003792 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 484022003793 CoenzymeA binding site [chemical binding]; other site 484022003794 subunit interaction site [polypeptide binding]; other site 484022003795 PHB binding site; other site 484022003796 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 484022003797 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 484022003798 dimer interface [polypeptide binding]; other site 484022003799 active site 484022003800 Acyl CoA binding protein; Region: ACBP; pfam00887 484022003801 acyl-CoA binding pocket [chemical binding]; other site 484022003802 CoA binding site [chemical binding]; other site 484022003803 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 484022003804 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 484022003805 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 484022003806 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 484022003807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 484022003808 substrate binding site [chemical binding]; other site 484022003809 oxyanion hole (OAH) forming residues; other site 484022003810 trimer interface [polypeptide binding]; other site 484022003811 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 484022003812 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 484022003813 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 484022003814 active site 484022003815 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 484022003816 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 484022003817 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 484022003818 acyl-activating enzyme (AAE) consensus motif; other site 484022003819 putative AMP binding site [chemical binding]; other site 484022003820 putative active site [active] 484022003821 putative CoA binding site [chemical binding]; other site 484022003822 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 484022003823 ArsC family; Region: ArsC; pfam03960 484022003824 catalytic residues [active] 484022003825 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 484022003826 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 484022003827 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 484022003828 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022003829 ATP binding site [chemical binding]; other site 484022003830 putative Mg++ binding site [ion binding]; other site 484022003831 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022003832 nucleotide binding region [chemical binding]; other site 484022003833 ATP-binding site [chemical binding]; other site 484022003834 Helicase associated domain (HA2); Region: HA2; pfam04408 484022003835 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 484022003836 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 484022003837 CoA-binding domain; Region: CoA_binding_3; pfam13727 484022003838 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 484022003839 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 484022003840 NAD(P) binding site [chemical binding]; other site 484022003841 homodimer interface [polypeptide binding]; other site 484022003842 substrate binding site [chemical binding]; other site 484022003843 active site 484022003844 Bacterial sugar transferase; Region: Bac_transf; pfam02397 484022003845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003846 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 484022003847 NAD(P) binding site [chemical binding]; other site 484022003848 active site 484022003849 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 484022003850 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 484022003851 Substrate binding site; other site 484022003852 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 484022003853 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 484022003854 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 484022003855 NADP-binding site; other site 484022003856 homotetramer interface [polypeptide binding]; other site 484022003857 substrate binding site [chemical binding]; other site 484022003858 homodimer interface [polypeptide binding]; other site 484022003859 active site 484022003860 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 484022003861 four helix bundle protein; Region: TIGR02436 484022003862 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 484022003863 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 484022003864 NADP binding site [chemical binding]; other site 484022003865 active site 484022003866 putative substrate binding site [chemical binding]; other site 484022003867 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 484022003868 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 484022003869 substrate binding site; other site 484022003870 tetramer interface; other site 484022003871 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 484022003872 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 484022003873 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 484022003874 NADP binding site [chemical binding]; other site 484022003875 active site 484022003876 putative substrate binding site [chemical binding]; other site 484022003877 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 484022003878 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 484022003879 NAD binding site [chemical binding]; other site 484022003880 substrate binding site [chemical binding]; other site 484022003881 homodimer interface [polypeptide binding]; other site 484022003882 active site 484022003883 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 484022003884 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 484022003885 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 484022003886 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 484022003887 Walker A/P-loop; other site 484022003888 ATP binding site [chemical binding]; other site 484022003889 Q-loop/lid; other site 484022003890 ABC transporter signature motif; other site 484022003891 Walker B; other site 484022003892 D-loop; other site 484022003893 H-loop/switch region; other site 484022003894 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 484022003895 putative carbohydrate binding site [chemical binding]; other site 484022003896 WxcM-like, C-terminal; Region: FdtA; pfam05523 484022003897 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 484022003898 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 484022003899 putative trimer interface [polypeptide binding]; other site 484022003900 putative CoA binding site [chemical binding]; other site 484022003901 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 484022003902 active site 484022003903 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 484022003904 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 484022003905 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 484022003906 inhibitor-cofactor binding pocket; inhibition site 484022003907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022003908 catalytic residue [active] 484022003909 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 484022003910 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 484022003911 active site 484022003912 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484022003913 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484022003914 Rhamnan synthesis protein F; Region: RgpF; pfam05045 484022003915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484022003916 NAD(P) binding site [chemical binding]; other site 484022003917 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 484022003918 active site 484022003919 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 484022003920 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484022003921 active site 484022003922 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 484022003923 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484022003924 active site 484022003925 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 484022003926 metal-binding site 484022003927 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484022003928 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 484022003929 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484022003930 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 484022003931 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 484022003932 metal-binding site 484022003933 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 484022003934 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 484022003935 active site 484022003936 substrate binding site [chemical binding]; other site 484022003937 metal binding site [ion binding]; metal-binding site 484022003938 transcription termination factor Rho; Provisional; Region: rho; PRK09376 484022003939 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 484022003940 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 484022003941 RNA binding site [nucleotide binding]; other site 484022003942 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 484022003943 multimer interface [polypeptide binding]; other site 484022003944 Walker A motif; other site 484022003945 ATP binding site [chemical binding]; other site 484022003946 Walker B motif; other site 484022003947 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 484022003948 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 484022003949 catalytic residues [active] 484022003950 exopolyphosphatase; Region: exo_poly_only; TIGR03706 484022003951 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 484022003952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484022003953 Walker A motif; other site 484022003954 ATP binding site [chemical binding]; other site 484022003955 Walker B motif; other site 484022003956 recombination factor protein RarA; Provisional; Region: PRK14700 484022003957 arginine finger; other site 484022003958 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 484022003959 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 484022003960 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 484022003961 dimer interface [polypeptide binding]; other site 484022003962 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 484022003963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003964 putative substrate translocation pore; other site 484022003965 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 484022003966 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 484022003967 active site 484022003968 Cupin domain; Region: Cupin_2; cl17218 484022003969 Protein of unknown function (DUF523); Region: DUF523; cl00733 484022003970 hypothetical protein; Provisional; Region: PRK10621 484022003971 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 484022003972 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 484022003973 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 484022003974 Walker A/P-loop; other site 484022003975 ATP binding site [chemical binding]; other site 484022003976 Q-loop/lid; other site 484022003977 ABC transporter signature motif; other site 484022003978 Walker B; other site 484022003979 D-loop; other site 484022003980 H-loop/switch region; other site 484022003981 inner membrane transport permease; Provisional; Region: PRK15066 484022003982 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 484022003983 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 484022003984 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 484022003985 Ligand binding site; other site 484022003986 Putative Catalytic site; other site 484022003987 DXD motif; other site 484022003988 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 484022003989 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 484022003990 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 484022003991 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 484022003992 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 484022003993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484022003994 Coenzyme A binding pocket [chemical binding]; other site 484022003995 guanine deaminase; Provisional; Region: PRK09228 484022003996 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 484022003997 active site 484022003998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022003999 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022004000 putative substrate translocation pore; other site 484022004001 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484022004002 dimerization interface [polypeptide binding]; other site 484022004003 putative DNA binding site [nucleotide binding]; other site 484022004004 putative Zn2+ binding site [ion binding]; other site 484022004005 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 484022004006 active site residue [active] 484022004007 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 484022004008 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484022004009 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484022004010 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484022004011 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 484022004012 active site residue [active] 484022004013 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 484022004014 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 484022004015 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 484022004016 hypothetical protein; Provisional; Region: PRK05170 484022004017 transcription antitermination factor NusB; Region: nusB; TIGR01951 484022004018 putative RNA binding site [nucleotide binding]; other site 484022004019 C-N hydrolase family amidase; Provisional; Region: PRK10438 484022004020 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 484022004021 putative active site [active] 484022004022 catalytic triad [active] 484022004023 dimer interface [polypeptide binding]; other site 484022004024 multimer interface [polypeptide binding]; other site 484022004025 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 484022004026 methionine aminotransferase; Validated; Region: PRK09082 484022004027 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484022004028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022004029 homodimer interface [polypeptide binding]; other site 484022004030 catalytic residue [active] 484022004031 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004032 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022004033 Integrase core domain; Region: rve; pfam00665 484022004034 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 484022004035 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 484022004036 Acyltransferase family; Region: Acyl_transf_3; pfam01757 484022004037 prolyl-tRNA synthetase; Provisional; Region: PRK09194 484022004038 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 484022004039 dimer interface [polypeptide binding]; other site 484022004040 motif 1; other site 484022004041 active site 484022004042 motif 2; other site 484022004043 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 484022004044 putative deacylase active site [active] 484022004045 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 484022004046 active site 484022004047 motif 3; other site 484022004048 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 484022004049 anticodon binding site; other site 484022004050 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 484022004051 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 484022004052 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 484022004053 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 484022004054 active site 484022004055 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 484022004056 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 484022004057 Sporulation related domain; Region: SPOR; pfam05036 484022004058 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 484022004059 Methyltransferase domain; Region: Methyltransf_23; pfam13489 484022004060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022004061 S-adenosylmethionine binding site [chemical binding]; other site 484022004062 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 484022004063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484022004064 non-specific DNA binding site [nucleotide binding]; other site 484022004065 salt bridge; other site 484022004066 sequence-specific DNA binding site [nucleotide binding]; other site 484022004067 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 484022004068 Catalytic site [active] 484022004069 EamA-like transporter family; Region: EamA; pfam00892 484022004070 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 484022004071 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 484022004072 active site 484022004073 FMN binding site [chemical binding]; other site 484022004074 substrate binding site [chemical binding]; other site 484022004075 3Fe-4S cluster binding site [ion binding]; other site 484022004076 Cupin-like domain; Region: Cupin_8; pfam13621 484022004077 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 484022004078 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 484022004079 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 484022004080 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 484022004081 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 484022004082 active site 484022004083 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 484022004084 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 484022004085 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 484022004086 PYR/PP interface [polypeptide binding]; other site 484022004087 dimer interface [polypeptide binding]; other site 484022004088 TPP binding site [chemical binding]; other site 484022004089 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484022004090 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 484022004091 TPP-binding site; other site 484022004092 dimer interface [polypeptide binding]; other site 484022004093 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 484022004094 Family description; Region: UvrD_C_2; pfam13538 484022004095 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 484022004096 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 484022004097 AAA domain; Region: AAA_30; pfam13604 484022004098 Family description; Region: UvrD_C_2; pfam13538 484022004099 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484022004100 nucleotide binding site [chemical binding]; other site 484022004101 Type III pantothenate kinase; Region: Pan_kinase; cl17198 484022004102 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 484022004103 tetramerization interface [polypeptide binding]; other site 484022004104 active site 484022004105 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022004106 pantoate--beta-alanine ligase; Region: panC; TIGR00018 484022004107 active site 484022004108 nucleotide binding site [chemical binding]; other site 484022004109 HIGH motif; other site 484022004110 KMSKS motif; other site 484022004111 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 484022004112 active site 484022004113 oligomerization interface [polypeptide binding]; other site 484022004114 metal binding site [ion binding]; metal-binding site 484022004115 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 484022004116 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 484022004117 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 484022004118 nucleotide binding pocket [chemical binding]; other site 484022004119 K-X-D-G motif; other site 484022004120 catalytic site [active] 484022004121 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 484022004122 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 484022004123 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 484022004124 Dimer interface [polypeptide binding]; other site 484022004125 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 484022004126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 484022004127 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 484022004128 16S rRNA methyltransferase B; Provisional; Region: PRK10901 484022004129 NusB family; Region: NusB; pfam01029 484022004130 putative RNA binding site [nucleotide binding]; other site 484022004131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022004132 S-adenosylmethionine binding site [chemical binding]; other site 484022004133 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 484022004134 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 484022004135 active site 484022004136 dimerization interface [polypeptide binding]; other site 484022004137 Predicted membrane protein [Function unknown]; Region: COG2855 484022004138 putative transporter; Provisional; Region: PRK03699 484022004139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004140 putative substrate translocation pore; other site 484022004141 Uncharacterized conserved protein [Function unknown]; Region: COG4121 484022004142 YCII-related domain; Region: YCII; cl00999 484022004143 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 484022004144 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 484022004145 dimer interface [polypeptide binding]; other site 484022004146 active site 484022004147 acyl carrier protein; Provisional; Region: acpP; PRK00982 484022004148 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 484022004149 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 484022004150 NAD(P) binding site [chemical binding]; other site 484022004151 homotetramer interface [polypeptide binding]; other site 484022004152 homodimer interface [polypeptide binding]; other site 484022004153 active site 484022004154 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 484022004155 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 484022004156 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 484022004157 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 484022004158 dimer interface [polypeptide binding]; other site 484022004159 active site 484022004160 CoA binding pocket [chemical binding]; other site 484022004161 putative phosphate acyltransferase; Provisional; Region: PRK05331 484022004162 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 484022004163 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 484022004164 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 484022004165 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 484022004166 TPP-binding site [chemical binding]; other site 484022004167 dimer interface [polypeptide binding]; other site 484022004168 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 484022004169 PYR/PP interface [polypeptide binding]; other site 484022004170 dimer interface [polypeptide binding]; other site 484022004171 TPP binding site [chemical binding]; other site 484022004172 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 484022004173 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 484022004174 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 484022004175 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 484022004176 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 484022004177 Phosphoglycerate kinase; Region: PGK; pfam00162 484022004178 substrate binding site [chemical binding]; other site 484022004179 hinge regions; other site 484022004180 ADP binding site [chemical binding]; other site 484022004181 catalytic site [active] 484022004182 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 484022004183 pyruvate kinase; Provisional; Region: PRK05826 484022004184 domain interfaces; other site 484022004185 active site 484022004186 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 484022004187 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 484022004188 intersubunit interface [polypeptide binding]; other site 484022004189 active site 484022004190 zinc binding site [ion binding]; other site 484022004191 Na+ binding site [ion binding]; other site 484022004192 Trehalase; Region: Trehalase; cl17346 484022004193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004194 putative substrate translocation pore; other site 484022004195 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022004196 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 484022004197 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 484022004198 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 484022004199 Protein of unknown function (DUF877); Region: DUF877; pfam05943 484022004200 Intracellular growth locus C protein; Region: IglC; pfam11550 484022004201 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 484022004202 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 484022004203 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 484022004204 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 484022004205 dimer interface [polypeptide binding]; other site 484022004206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022004207 catalytic residue [active] 484022004208 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 484022004209 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 484022004210 active site 484022004211 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484022004212 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484022004213 putative Zn2+ binding site [ion binding]; other site 484022004214 putative DNA binding site [nucleotide binding]; other site 484022004215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484022004216 dimerization interface [polypeptide binding]; other site 484022004217 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 484022004218 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 484022004219 trmE is a tRNA modification GTPase; Region: trmE; cd04164 484022004220 G1 box; other site 484022004221 GTP/Mg2+ binding site [chemical binding]; other site 484022004222 Switch I region; other site 484022004223 G2 box; other site 484022004224 Switch II region; other site 484022004225 G3 box; other site 484022004226 G4 box; other site 484022004227 G5 box; other site 484022004228 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 484022004229 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 484022004230 30S subunit binding site; other site 484022004231 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484022004232 active site 484022004233 phosphorylation site [posttranslational modification] 484022004234 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 484022004235 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 484022004236 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 484022004237 RNA/DNA hybrid binding site [nucleotide binding]; other site 484022004238 active site 484022004239 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 484022004240 Na binding site [ion binding]; other site 484022004241 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 484022004242 PAS fold; Region: PAS_4; pfam08448 484022004243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 484022004244 putative active site [active] 484022004245 heme pocket [chemical binding]; other site 484022004246 Transcriptional regulators [Transcription]; Region: MarR; COG1846 484022004247 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 484022004248 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 484022004249 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004250 Integrase core domain; Region: rve; pfam00665 484022004251 Integrase core domain; Region: rve_3; cl15866 484022004252 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022004253 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 484022004254 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 484022004255 active site 484022004256 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 484022004257 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484022004258 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 484022004259 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 484022004260 23S rRNA interface [nucleotide binding]; other site 484022004261 L3 interface [polypeptide binding]; other site 484022004262 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 484022004263 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 484022004264 MltA specific insert domain; Region: MltA; smart00925 484022004265 3D domain; Region: 3D; pfam06725 484022004266 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 484022004267 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 484022004268 dimer interface [polypeptide binding]; other site 484022004269 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 484022004270 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 484022004271 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 484022004272 nucleotide binding site [chemical binding]; other site 484022004273 chaperone protein DnaJ; Provisional; Region: PRK10767 484022004274 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 484022004275 HSP70 interaction site [polypeptide binding]; other site 484022004276 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 484022004277 substrate binding site [polypeptide binding]; other site 484022004278 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 484022004279 Zn binding sites [ion binding]; other site 484022004280 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 484022004281 dimer interface [polypeptide binding]; other site 484022004282 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 484022004283 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 484022004284 homodimer interface [polypeptide binding]; other site 484022004285 NAD binding pocket [chemical binding]; other site 484022004286 ATP binding pocket [chemical binding]; other site 484022004287 Mg binding site [ion binding]; other site 484022004288 active-site loop [active] 484022004289 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 484022004290 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 484022004291 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484022004292 HlyD family secretion protein; Region: HlyD_3; pfam13437 484022004293 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 484022004294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004295 putative substrate translocation pore; other site 484022004296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004297 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 484022004298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484022004299 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 484022004300 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 484022004301 acyl-activating enzyme (AAE) consensus motif; other site 484022004302 putative active site [active] 484022004303 putative AMP binding site [chemical binding]; other site 484022004304 putative CoA binding site [chemical binding]; other site 484022004305 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 484022004306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004307 putative substrate translocation pore; other site 484022004308 POT family; Region: PTR2; cl17359 484022004309 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 484022004310 RNA methyltransferase, RsmE family; Region: TIGR00046 484022004311 Protein of unknown function (DUF445); Region: DUF445; pfam04286 484022004312 mce related protein; Region: MCE; pfam02470 484022004313 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 484022004314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484022004315 Walker A/P-loop; other site 484022004316 ATP binding site [chemical binding]; other site 484022004317 Q-loop/lid; other site 484022004318 ABC transporter signature motif; other site 484022004319 Walker B; other site 484022004320 D-loop; other site 484022004321 H-loop/switch region; other site 484022004322 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 484022004323 Permease; Region: Permease; pfam02405 484022004324 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 484022004325 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 484022004326 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484022004327 RNA binding surface [nucleotide binding]; other site 484022004328 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 484022004329 active site 484022004330 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 484022004331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 484022004332 TPR motif; other site 484022004333 binding surface 484022004334 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 484022004335 FAD binding domain; Region: FAD_binding_4; pfam01565 484022004336 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 484022004337 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 484022004338 dimer interface [polypeptide binding]; other site 484022004339 active site 484022004340 glycine-pyridoxal phosphate binding site [chemical binding]; other site 484022004341 folate binding site [chemical binding]; other site 484022004342 hypothetical protein; Provisional; Region: PRK05255 484022004343 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 484022004344 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 484022004345 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 484022004346 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484022004347 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 484022004348 Ligand Binding Site [chemical binding]; other site 484022004349 TilS substrate C-terminal domain; Region: TilS_C; smart00977 484022004350 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 484022004351 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 484022004352 ligand binding site [chemical binding]; other site 484022004353 NAD binding site [chemical binding]; other site 484022004354 tetramer interface [polypeptide binding]; other site 484022004355 catalytic site [active] 484022004356 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 484022004357 L-serine binding site [chemical binding]; other site 484022004358 ACT domain interface; other site 484022004359 thymidylate synthase; Reviewed; Region: thyA; PRK01827 484022004360 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 484022004361 dimerization interface [polypeptide binding]; other site 484022004362 active site 484022004363 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 484022004364 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 484022004365 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 484022004366 homodimer interface [polypeptide binding]; other site 484022004367 oligonucleotide binding site [chemical binding]; other site 484022004368 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 484022004369 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 484022004370 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022004371 catalytic residue [active] 484022004372 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 484022004373 Recombination protein O N terminal; Region: RecO_N; pfam11967 484022004374 Recombination protein O C terminal; Region: RecO_C; pfam02565 484022004375 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 484022004376 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 484022004377 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 484022004378 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 484022004379 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 484022004380 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 484022004381 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 484022004382 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 484022004383 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 484022004384 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 484022004385 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 484022004386 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 484022004387 active site 484022004388 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 484022004389 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 484022004390 DEAD-like helicases superfamily; Region: DEXDc; smart00487 484022004391 ATP binding site [chemical binding]; other site 484022004392 putative Mg++ binding site [ion binding]; other site 484022004393 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022004394 nucleotide binding region [chemical binding]; other site 484022004395 ATP-binding site [chemical binding]; other site 484022004396 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 484022004397 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 484022004398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484022004399 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 484022004400 active site 484022004401 motif I; other site 484022004402 motif II; other site 484022004403 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 484022004404 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 484022004405 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 484022004406 dimer interface [polypeptide binding]; other site 484022004407 active site 484022004408 metal binding site [ion binding]; metal-binding site 484022004409 glutathione binding site [chemical binding]; other site 484022004410 Methyltransferase domain; Region: Methyltransf_31; pfam13847 484022004411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022004412 S-adenosylmethionine binding site [chemical binding]; other site 484022004413 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 484022004414 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 484022004415 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 484022004416 NAD binding site [chemical binding]; other site 484022004417 homotetramer interface [polypeptide binding]; other site 484022004418 homodimer interface [polypeptide binding]; other site 484022004419 substrate binding site [chemical binding]; other site 484022004420 active site 484022004421 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 484022004422 hypothetical protein; Provisional; Region: PRK05409 484022004423 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 484022004424 DoxX; Region: DoxX; pfam07681 484022004425 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 484022004426 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 484022004427 putative active site [active] 484022004428 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 484022004429 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 484022004430 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 484022004431 substrate binding site [chemical binding]; other site 484022004432 hexamer interface [polypeptide binding]; other site 484022004433 metal binding site [ion binding]; metal-binding site 484022004434 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 484022004435 Bacterial sugar transferase; Region: Bac_transf; pfam02397 484022004436 UDP-glucose 4-epimerase; Region: PLN02240 484022004437 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 484022004438 NAD binding site [chemical binding]; other site 484022004439 homodimer interface [polypeptide binding]; other site 484022004440 active site 484022004441 substrate binding site [chemical binding]; other site 484022004442 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484022004443 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 484022004444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484022004445 Walker A/P-loop; other site 484022004446 ATP binding site [chemical binding]; other site 484022004447 Q-loop/lid; other site 484022004448 ABC transporter signature motif; other site 484022004449 Walker B; other site 484022004450 D-loop; other site 484022004451 H-loop/switch region; other site 484022004452 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 484022004453 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 484022004454 dimer interface [polypeptide binding]; other site 484022004455 active site 484022004456 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 484022004457 Ligand Binding Site [chemical binding]; other site 484022004458 Molecular Tunnel; other site 484022004459 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 484022004460 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022004461 active site 484022004462 nucleotide binding site [chemical binding]; other site 484022004463 HIGH motif; other site 484022004464 KMSKS motif; other site 484022004465 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 484022004466 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 484022004467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 484022004468 active site 484022004469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484022004470 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 484022004471 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484022004472 active site 484022004473 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484022004474 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 484022004475 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 484022004476 metal-binding site 484022004477 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484022004478 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 484022004479 putative ADP-binding pocket [chemical binding]; other site 484022004480 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 484022004481 active site 484022004482 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 484022004483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484022004484 motif II; other site 484022004485 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484022004486 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 484022004487 substrate binding site [chemical binding]; other site 484022004488 ATP binding site [chemical binding]; other site 484022004489 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 484022004490 proposed catalytic triad [active] 484022004491 active site nucleophile [active] 484022004492 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 484022004493 catalytic nucleophile [active] 484022004494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004495 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022004496 putative substrate translocation pore; other site 484022004497 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 484022004498 Fungal protease inhibitor; Region: amfpi-1; pfam12190 484022004499 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 484022004500 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 484022004501 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 484022004502 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484022004503 Zn2+ binding site [ion binding]; other site 484022004504 Mg2+ binding site [ion binding]; other site 484022004505 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 484022004506 synthetase active site [active] 484022004507 NTP binding site [chemical binding]; other site 484022004508 metal binding site [ion binding]; metal-binding site 484022004509 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 484022004510 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 484022004511 MULE transposase domain; Region: MULE; pfam10551 484022004512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 484022004513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 484022004514 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 484022004515 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 484022004516 putative active site [active] 484022004517 catalytic site [active] 484022004518 putative metal binding site [ion binding]; other site 484022004519 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 484022004520 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 484022004521 putative MPT binding site; other site 484022004522 cyanophycin synthetase; Provisional; Region: PRK14016 484022004523 ATP-grasp domain; Region: ATP-grasp_4; cl17255 484022004524 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484022004525 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484022004526 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484022004527 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484022004528 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 484022004529 homotrimer interaction site [polypeptide binding]; other site 484022004530 zinc binding site [ion binding]; other site 484022004531 CDP-binding sites; other site 484022004532 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 484022004533 active site residue [active] 484022004534 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 484022004535 active site residue [active] 484022004536 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 484022004537 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004538 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022004539 Integrase core domain; Region: rve; pfam00665 484022004540 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 484022004541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484022004542 dimer interface [polypeptide binding]; other site 484022004543 conserved gate region; other site 484022004544 ABC-ATPase subunit interface; other site 484022004545 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 484022004546 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 484022004547 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 484022004548 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 484022004549 Walker A/P-loop; other site 484022004550 ATP binding site [chemical binding]; other site 484022004551 Q-loop/lid; other site 484022004552 ABC transporter signature motif; other site 484022004553 Walker B; other site 484022004554 D-loop; other site 484022004555 H-loop/switch region; other site 484022004556 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 484022004557 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 484022004558 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 484022004559 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 484022004560 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 484022004561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484022004562 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484022004563 dimerization interface [polypeptide binding]; other site 484022004564 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004565 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022004566 Integrase core domain; Region: rve; pfam00665 484022004567 Isochorismatase family; Region: Isochorismatase; pfam00857 484022004568 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 484022004569 catalytic triad [active] 484022004570 conserved cis-peptide bond; other site 484022004571 putative transporter; Provisional; Region: PRK03699 484022004572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004573 putative substrate translocation pore; other site 484022004574 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 484022004575 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 484022004576 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 484022004577 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 484022004578 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 484022004579 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 484022004580 Protein export membrane protein; Region: SecD_SecF; pfam02355 484022004581 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 484022004582 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 484022004583 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 484022004584 DNA binding residues [nucleotide binding] 484022004585 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 484022004586 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 484022004587 hinge; other site 484022004588 active site 484022004589 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 484022004590 RNA/DNA hybrid binding site [nucleotide binding]; other site 484022004591 active site 484022004592 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 484022004593 active site 484022004594 homodimer interface [polypeptide binding]; other site 484022004595 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 484022004596 active site clefts [active] 484022004597 zinc binding site [ion binding]; other site 484022004598 dimer interface [polypeptide binding]; other site 484022004599 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 484022004600 DEAD-like helicases superfamily; Region: DEXDc; smart00487 484022004601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022004602 ATP binding site [chemical binding]; other site 484022004603 putative Mg++ binding site [ion binding]; other site 484022004604 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 484022004605 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004606 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022004607 Integrase core domain; Region: rve; pfam00665 484022004608 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 484022004609 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 484022004610 Transposase IS200 like; Region: Y1_Tnp; cl00848 484022004611 HsdM N-terminal domain; Region: HsdM_N; pfam12161 484022004612 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004613 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022004614 Integrase core domain; Region: rve; pfam00665 484022004615 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 484022004616 Methyltransferase domain; Region: Methyltransf_26; pfam13659 484022004617 trigger factor; Provisional; Region: tig; PRK01490 484022004618 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 484022004619 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 484022004620 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 484022004621 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 484022004622 oligomer interface [polypeptide binding]; other site 484022004623 active site residues [active] 484022004624 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 484022004625 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 484022004626 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 484022004627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484022004628 Walker A motif; other site 484022004629 ATP binding site [chemical binding]; other site 484022004630 Walker B motif; other site 484022004631 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 484022004632 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 484022004633 Found in ATP-dependent protease La (LON); Region: LON; smart00464 484022004634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484022004635 Walker A motif; other site 484022004636 ATP binding site [chemical binding]; other site 484022004637 Walker B motif; other site 484022004638 arginine finger; other site 484022004639 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 484022004640 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 484022004641 IHF dimer interface [polypeptide binding]; other site 484022004642 IHF - DNA interface [nucleotide binding]; other site 484022004643 SurA N-terminal domain; Region: SurA_N_3; cl07813 484022004644 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 484022004645 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 484022004646 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 484022004647 bacterial Hfq-like; Region: Hfq; cd01716 484022004648 hexamer interface [polypeptide binding]; other site 484022004649 Sm1 motif; other site 484022004650 RNA binding site [nucleotide binding]; other site 484022004651 Sm2 motif; other site 484022004652 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 484022004653 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 484022004654 HflX GTPase family; Region: HflX; cd01878 484022004655 G1 box; other site 484022004656 GTP/Mg2+ binding site [chemical binding]; other site 484022004657 Switch I region; other site 484022004658 G2 box; other site 484022004659 G3 box; other site 484022004660 Switch II region; other site 484022004661 G4 box; other site 484022004662 G5 box; other site 484022004663 hypothetical protein; Provisional; Region: PRK07588 484022004664 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 484022004665 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 484022004666 HflK protein; Region: hflK; TIGR01933 484022004667 FtsH protease regulator HflC; Provisional; Region: PRK11029 484022004668 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 484022004669 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 484022004670 Low molecular weight phosphatase family; Region: LMWPc; cd00115 484022004671 active site 484022004672 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 484022004673 G1 box; other site 484022004674 GTP/Mg2+ binding site [chemical binding]; other site 484022004675 Switch I region; other site 484022004676 G2 box; other site 484022004677 G3 box; other site 484022004678 Switch II region; other site 484022004679 G4 box; other site 484022004680 G5 box; other site 484022004681 threonine synthase; Reviewed; Region: PRK06721 484022004682 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 484022004683 homodimer interface [polypeptide binding]; other site 484022004684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022004685 catalytic residue [active] 484022004686 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 484022004687 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 484022004688 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 484022004689 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 484022004690 PYR/PP interface [polypeptide binding]; other site 484022004691 dimer interface [polypeptide binding]; other site 484022004692 TPP binding site [chemical binding]; other site 484022004693 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484022004694 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 484022004695 TPP-binding site [chemical binding]; other site 484022004696 dimer interface [polypeptide binding]; other site 484022004697 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 484022004698 putative valine binding site [chemical binding]; other site 484022004699 dimer interface [polypeptide binding]; other site 484022004700 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 484022004701 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 484022004702 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 484022004703 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 484022004704 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 484022004705 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022004706 ATP binding site [chemical binding]; other site 484022004707 putative Mg++ binding site [ion binding]; other site 484022004708 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022004709 nucleotide binding region [chemical binding]; other site 484022004710 ATP-binding site [chemical binding]; other site 484022004711 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 484022004712 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 484022004713 YccA-like proteins; Region: YccA_like; cd10433 484022004714 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004715 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022004716 Integrase core domain; Region: rve; pfam00665 484022004717 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 484022004718 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 484022004719 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 484022004720 minor groove reading motif; other site 484022004721 helix-hairpin-helix signature motif; other site 484022004722 substrate binding pocket [chemical binding]; other site 484022004723 active site 484022004724 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 484022004725 ferredoxin; Provisional; Region: PRK08764 484022004726 Putative Fe-S cluster; Region: FeS; cl17515 484022004727 4Fe-4S binding domain; Region: Fer4; pfam00037 484022004728 glutaredoxin 2; Provisional; Region: PRK10387 484022004729 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484022004730 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 484022004731 N-terminal domain interface [polypeptide binding]; other site 484022004732 Patatin-like phospholipase; Region: Patatin; pfam01734 484022004733 nucleophile elbow; other site 484022004734 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004735 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022004736 Integrase core domain; Region: rve; pfam00665 484022004737 POT family; Region: PTR2; cl17359 484022004738 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 484022004739 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 484022004740 Ferritin-like domain; Region: Ferritin; pfam00210 484022004741 ferroxidase diiron center [ion binding]; other site 484022004742 lipoyl synthase; Provisional; Region: PRK05481 484022004743 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484022004744 FeS/SAM binding site; other site 484022004745 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 484022004746 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 484022004747 conserved cys residue [active] 484022004748 hypothetical protein; Validated; Region: PRK00110 484022004749 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 484022004750 active site 484022004751 putative DNA-binding cleft [nucleotide binding]; other site 484022004752 dimer interface [polypeptide binding]; other site 484022004753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004754 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022004755 putative substrate translocation pore; other site 484022004756 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 484022004757 RuvA N terminal domain; Region: RuvA_N; pfam01330 484022004758 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 484022004759 RmuC family; Region: RmuC; pfam02646 484022004760 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 484022004761 dimerization interface [polypeptide binding]; other site 484022004762 putative Zn2+ binding site [ion binding]; other site 484022004763 putative DNA binding site [nucleotide binding]; other site 484022004764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 484022004765 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 484022004766 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 484022004767 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484022004768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022004769 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022004770 putative substrate translocation pore; other site 484022004771 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 484022004772 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 484022004773 putative active site [active] 484022004774 Zn binding site [ion binding]; other site 484022004775 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 484022004776 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 484022004777 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484022004778 active site 484022004779 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 484022004780 5S rRNA interface [nucleotide binding]; other site 484022004781 CTC domain interface [polypeptide binding]; other site 484022004782 L16 interface [polypeptide binding]; other site 484022004783 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 484022004784 Domain of unknown function DUF21; Region: DUF21; pfam01595 484022004785 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 484022004786 Transporter associated domain; Region: CorC_HlyC; pfam03471 484022004787 GTP-binding protein YchF; Reviewed; Region: PRK09601 484022004788 YchF GTPase; Region: YchF; cd01900 484022004789 G1 box; other site 484022004790 GTP/Mg2+ binding site [chemical binding]; other site 484022004791 Switch I region; other site 484022004792 G2 box; other site 484022004793 Switch II region; other site 484022004794 G3 box; other site 484022004795 G4 box; other site 484022004796 G5 box; other site 484022004797 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 484022004798 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 484022004799 putative active site [active] 484022004800 catalytic residue [active] 484022004801 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 484022004802 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 484022004803 dimerization domain [polypeptide binding]; other site 484022004804 dimer interface [polypeptide binding]; other site 484022004805 catalytic residues [active] 484022004806 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 484022004807 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 484022004808 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 484022004809 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 484022004810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484022004811 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484022004812 Ion transport protein; Region: Ion_trans; pfam00520 484022004813 Ion channel; Region: Ion_trans_2; pfam07885 484022004814 TrkA-N domain; Region: TrkA_N; pfam02254 484022004815 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 484022004816 POT family; Region: PTR2; cl17359 484022004817 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 484022004818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484022004819 Walker A motif; other site 484022004820 ATP binding site [chemical binding]; other site 484022004821 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 484022004822 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 484022004823 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 484022004824 active site 484022004825 HslU subunit interaction site [polypeptide binding]; other site 484022004826 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 484022004827 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 484022004828 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 484022004829 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 484022004830 active site 484022004831 HIGH motif; other site 484022004832 dimer interface [polypeptide binding]; other site 484022004833 KMSKS motif; other site 484022004834 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484022004835 RNA binding surface [nucleotide binding]; other site 484022004836 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 484022004837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484022004838 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 484022004839 dimerization interface [polypeptide binding]; other site 484022004840 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 484022004841 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 484022004842 phosphate binding site [ion binding]; other site 484022004843 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 484022004844 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 484022004845 dimer interface [polypeptide binding]; other site 484022004846 PYR/PP interface [polypeptide binding]; other site 484022004847 TPP binding site [chemical binding]; other site 484022004848 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484022004849 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 484022004850 TPP-binding site [chemical binding]; other site 484022004851 dimer interface [polypeptide binding]; other site 484022004852 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 484022004853 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 484022004854 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 484022004855 FAD binding domain; Region: FAD_binding_4; pfam01565 484022004856 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 484022004857 Cysteine-rich domain; Region: CCG; pfam02754 484022004858 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484022004859 RNA binding surface [nucleotide binding]; other site 484022004860 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 484022004861 Fusaric acid resistance protein family; Region: FUSC; pfam04632 484022004862 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 484022004863 multidrug resistance protein MdtN; Provisional; Region: PRK10476 484022004864 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484022004865 HlyD family secretion protein; Region: HlyD_3; pfam13437 484022004866 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 484022004867 Transcriptional regulator [Transcription]; Region: IclR; COG1414 484022004868 Bacterial transcriptional regulator; Region: IclR; pfam01614 484022004869 Radical SAM superfamily; Region: Radical_SAM; pfam04055 484022004870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484022004871 FeS/SAM binding site; other site 484022004872 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022004873 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022004874 Integrase core domain; Region: rve; pfam00665 484022004875 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 484022004876 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 484022004877 putative active site [active] 484022004878 putative ligand binding site [chemical binding]; other site 484022004879 putative NAD(P) binding site [chemical binding]; other site 484022004880 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 484022004881 DNA-binding site [nucleotide binding]; DNA binding site 484022004882 RNA-binding motif; other site 484022004883 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 484022004884 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 484022004885 active site 484022004886 DNA polymerase IV; Validated; Region: PRK02406 484022004887 DNA binding site [nucleotide binding] 484022004888 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 484022004889 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 484022004890 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484022004891 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484022004892 ABC transporter; Region: ABC_tran_2; pfam12848 484022004893 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484022004894 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 484022004895 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 484022004896 GSH binding site [chemical binding]; other site 484022004897 catalytic residues [active] 484022004898 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 484022004899 dimer interface [polypeptide binding]; other site 484022004900 putative radical transfer pathway; other site 484022004901 diiron center [ion binding]; other site 484022004902 tyrosyl radical; other site 484022004903 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 484022004904 GSH binding site [chemical binding]; other site 484022004905 catalytic residues [active] 484022004906 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 484022004907 Class I ribonucleotide reductase; Region: RNR_I; cd01679 484022004908 active site 484022004909 dimer interface [polypeptide binding]; other site 484022004910 catalytic residues [active] 484022004911 effector binding site; other site 484022004912 R2 peptide binding site; other site 484022004913 malate dehydrogenase; Reviewed; Region: PRK06223 484022004914 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 484022004915 NAD(P) binding site [chemical binding]; other site 484022004916 dimer interface [polypeptide binding]; other site 484022004917 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484022004918 substrate binding site [chemical binding]; other site 484022004919 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 484022004920 diiron binding motif [ion binding]; other site 484022004921 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484022004922 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484022004923 catalytic residue [active] 484022004924 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 484022004925 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 484022004926 putative ATP binding site [chemical binding]; other site 484022004927 putative substrate interface [chemical binding]; other site 484022004928 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 484022004929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484022004930 motif II; other site 484022004931 peroxidase; Provisional; Region: PRK15000 484022004932 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 484022004933 dimer interface [polypeptide binding]; other site 484022004934 decamer (pentamer of dimers) interface [polypeptide binding]; other site 484022004935 catalytic triad [active] 484022004936 peroxidatic and resolving cysteines [active] 484022004937 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 484022004938 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 484022004939 PhnA protein; Region: PhnA; pfam03831 484022004940 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 484022004941 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 484022004942 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 484022004943 active site 484022004944 catalytic site [active] 484022004945 substrate binding site [chemical binding]; other site 484022004946 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 484022004947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 484022004948 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 484022004949 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 484022004950 aldehyde dehydrogenase family 7 member; Region: PLN02315 484022004951 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 484022004952 tetrameric interface [polypeptide binding]; other site 484022004953 NAD binding site [chemical binding]; other site 484022004954 catalytic residues [active] 484022004955 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 484022004956 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 484022004957 putative homodimer interface [polypeptide binding]; other site 484022004958 putative homotetramer interface [polypeptide binding]; other site 484022004959 putative allosteric switch controlling residues; other site 484022004960 putative metal binding site [ion binding]; other site 484022004961 putative homodimer-homodimer interface [polypeptide binding]; other site 484022004962 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484022004963 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 484022004964 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 484022004965 Multicopper oxidase; Region: Cu-oxidase; pfam00394 484022004966 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 484022004967 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 484022004968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484022004969 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 484022004970 dimerization interface [polypeptide binding]; other site 484022004971 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 484022004972 catalytic triad [active] 484022004973 dimer interface [polypeptide binding]; other site 484022004974 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 484022004975 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 484022004976 putative NAD(P) binding site [chemical binding]; other site 484022004977 homodimer interface [polypeptide binding]; other site 484022004978 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 484022004979 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 484022004980 tetramer interface [polypeptide binding]; other site 484022004981 heme binding pocket [chemical binding]; other site 484022004982 NADPH binding site [chemical binding]; other site 484022004983 Chorismate mutase type II; Region: CM_2; smart00830 484022004984 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 484022004985 catalytic residues [active] 484022004986 dimer interface [polypeptide binding]; other site 484022004987 Protein of unknown function (DUF819); Region: DUF819; cl02317 484022004988 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 484022004989 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 484022004990 active site 484022004991 Putative serine esterase (DUF676); Region: DUF676; pfam05057 484022004992 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 484022004993 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 484022004994 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 484022004995 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 484022004996 putative substrate binding site [chemical binding]; other site 484022004997 putative ATP binding site [chemical binding]; other site 484022004998 CRISPR-associated protein Cpf1, subtype PREFRAN; Region: cas_Cpf1; TIGR04330 484022004999 CRISPR-associated protein Cpf1, subtype PREFRAN; Region: cas_Cpf1; TIGR04330 484022005000 CRISPR-associated protein Cpf1, subtype PREFRAN; Region: cas_Cpf1; TIGR04330 484022005001 CRISPR-associated protein Cas4, subtype PREFRAN; Region: cas4_PREFRAN; TIGR04328 484022005002 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 484022005003 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 484022005004 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 484022005005 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 484022005006 nucleophilic elbow; other site 484022005007 catalytic triad; other site 484022005008 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 484022005009 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 484022005010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484022005011 FeS/SAM binding site; other site 484022005012 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 484022005013 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 484022005014 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 484022005015 active site 484022005016 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484022005017 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 484022005018 active site 484022005019 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 484022005020 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 484022005021 BCCT family transporter; Region: BCCT; pfam02028 484022005022 TspO/MBR family; Region: TspO_MBR; pfam03073 484022005023 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 484022005024 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 484022005025 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 484022005026 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 484022005027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005028 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 484022005029 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 484022005030 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 484022005031 catalytic residues [active] 484022005032 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 484022005033 epoxyqueuosine reductase; Region: TIGR00276 484022005034 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 484022005035 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 484022005036 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 484022005037 Part of AAA domain; Region: AAA_19; pfam13245 484022005038 Family description; Region: UvrD_C_2; pfam13538 484022005039 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 484022005040 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 484022005041 motif 1; other site 484022005042 active site 484022005043 motif 2; other site 484022005044 motif 3; other site 484022005045 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 484022005046 DHHA1 domain; Region: DHHA1; pfam02272 484022005047 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 484022005048 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 484022005049 interface (dimer of trimers) [polypeptide binding]; other site 484022005050 Substrate-binding/catalytic site; other site 484022005051 Zn-binding sites [ion binding]; other site 484022005052 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 484022005053 transaldolase-like protein; Provisional; Region: PTZ00411 484022005054 active site 484022005055 dimer interface [polypeptide binding]; other site 484022005056 catalytic residue [active] 484022005057 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 484022005058 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 484022005059 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 484022005060 Part of AAA domain; Region: AAA_19; pfam13245 484022005061 AAA domain; Region: AAA_14; pfam13173 484022005062 Family description; Region: UvrD_C_2; pfam13538 484022005063 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 484022005064 S1 domain; Region: S1_2; pfam13509 484022005065 S1 domain; Region: S1_2; pfam13509 484022005066 peroxiredoxin; Provisional; Region: PRK13189 484022005067 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 484022005068 dimer interface [polypeptide binding]; other site 484022005069 decamer (pentamer of dimers) interface [polypeptide binding]; other site 484022005070 catalytic triad [active] 484022005071 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 484022005072 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 484022005073 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 484022005074 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 484022005075 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 484022005076 replicative DNA helicase; Region: DnaB; TIGR00665 484022005077 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 484022005078 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 484022005079 Walker A motif; other site 484022005080 ATP binding site [chemical binding]; other site 484022005081 Walker B motif; other site 484022005082 DNA binding loops [nucleotide binding] 484022005083 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 484022005084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484022005085 FeS/SAM binding site; other site 484022005086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 484022005087 binding surface 484022005088 TPR motif; other site 484022005089 Tetratricopeptide repeat; Region: TPR_12; pfam13424 484022005090 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 484022005091 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484022005092 RNA binding surface [nucleotide binding]; other site 484022005093 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 484022005094 probable active site [active] 484022005095 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484022005096 Coenzyme A binding pocket [chemical binding]; other site 484022005097 PQ loop repeat; Region: PQ-loop; pfam04193 484022005098 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 484022005099 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 484022005100 substrate binding pocket [chemical binding]; other site 484022005101 chain length determination region; other site 484022005102 substrate-Mg2+ binding site; other site 484022005103 catalytic residues [active] 484022005104 aspartate-rich region 1; other site 484022005105 active site lid residues [active] 484022005106 aspartate-rich region 2; other site 484022005107 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 484022005108 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 484022005109 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 484022005110 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 484022005111 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 484022005112 Ligand Binding Site [chemical binding]; other site 484022005113 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 484022005114 active site 484022005115 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484022005116 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484022005117 catalytic residue [active] 484022005118 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 484022005119 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 484022005120 Yqey-like protein; Region: YqeY; pfam09424 484022005121 DNA primase; Validated; Region: dnaG; PRK05667 484022005122 CHC2 zinc finger; Region: zf-CHC2; pfam01807 484022005123 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 484022005124 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 484022005125 active site 484022005126 metal binding site [ion binding]; metal-binding site 484022005127 interdomain interaction site; other site 484022005128 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 484022005129 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 484022005130 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 484022005131 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 484022005132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 484022005133 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 484022005134 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 484022005135 DNA binding residues [nucleotide binding] 484022005136 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 484022005137 lipoate-protein ligase B; Provisional; Region: PRK14342 484022005138 Protein of unknown function (DUF493); Region: DUF493; pfam04359 484022005139 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 484022005140 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 484022005141 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 484022005142 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 484022005143 dimer interface [polypeptide binding]; other site 484022005144 substrate binding site [chemical binding]; other site 484022005145 metal binding sites [ion binding]; metal-binding site 484022005146 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 484022005147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484022005148 active site 484022005149 motif I; other site 484022005150 motif II; other site 484022005151 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 484022005152 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 484022005153 OstA-like protein; Region: OstA; cl00844 484022005154 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 484022005155 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 484022005156 Walker A/P-loop; other site 484022005157 ATP binding site [chemical binding]; other site 484022005158 Q-loop/lid; other site 484022005159 ABC transporter signature motif; other site 484022005160 Walker B; other site 484022005161 D-loop; other site 484022005162 H-loop/switch region; other site 484022005163 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 484022005164 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 484022005165 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 484022005166 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 484022005167 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 484022005168 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 484022005169 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 484022005170 dimerization interface 3.5A [polypeptide binding]; other site 484022005171 active site 484022005172 GMP synthase; Reviewed; Region: guaA; PRK00074 484022005173 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 484022005174 AMP/PPi binding site [chemical binding]; other site 484022005175 candidate oxyanion hole; other site 484022005176 catalytic triad [active] 484022005177 potential glutamine specificity residues [chemical binding]; other site 484022005178 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 484022005179 ATP Binding subdomain [chemical binding]; other site 484022005180 Ligand Binding sites [chemical binding]; other site 484022005181 Dimerization subdomain; other site 484022005182 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 484022005183 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 484022005184 TPP-binding site; other site 484022005185 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 484022005186 PYR/PP interface [polypeptide binding]; other site 484022005187 dimer interface [polypeptide binding]; other site 484022005188 TPP binding site [chemical binding]; other site 484022005189 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 484022005190 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 484022005191 active site 484022005192 catalytic triad [active] 484022005193 oxyanion hole [active] 484022005194 switch loop; other site 484022005195 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 484022005196 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 484022005197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484022005198 Walker A motif; other site 484022005199 ATP binding site [chemical binding]; other site 484022005200 Walker B motif; other site 484022005201 arginine finger; other site 484022005202 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 484022005203 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 484022005204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484022005205 non-specific DNA binding site [nucleotide binding]; other site 484022005206 salt bridge; other site 484022005207 sequence-specific DNA binding site [nucleotide binding]; other site 484022005208 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 484022005209 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 484022005210 catalytic motif [active] 484022005211 Catalytic residue [active] 484022005212 Aspartyl protease; Region: Asp_protease_2; pfam13650 484022005213 inhibitor binding site; inhibition site 484022005214 catalytic motif [active] 484022005215 Catalytic residue [active] 484022005216 Active site flap [active] 484022005217 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 484022005218 MFS/sugar transport protein; Region: MFS_2; pfam13347 484022005219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005220 putative substrate translocation pore; other site 484022005221 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 484022005222 EamA-like transporter family; Region: EamA; pfam00892 484022005223 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 484022005224 EamA-like transporter family; Region: EamA; pfam00892 484022005225 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 484022005226 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 484022005227 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 484022005228 dimer interface [polypeptide binding]; other site 484022005229 motif 1; other site 484022005230 active site 484022005231 motif 2; other site 484022005232 motif 3; other site 484022005233 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 484022005234 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 484022005235 putative tRNA-binding site [nucleotide binding]; other site 484022005236 B3/4 domain; Region: B3_4; pfam03483 484022005237 tRNA synthetase B5 domain; Region: B5; smart00874 484022005238 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 484022005239 dimer interface [polypeptide binding]; other site 484022005240 motif 1; other site 484022005241 motif 3; other site 484022005242 motif 2; other site 484022005243 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 484022005244 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 484022005245 metal binding site 2 [ion binding]; metal-binding site 484022005246 putative DNA binding helix; other site 484022005247 metal binding site 1 [ion binding]; metal-binding site 484022005248 dimer interface [polypeptide binding]; other site 484022005249 structural Zn2+ binding site [ion binding]; other site 484022005250 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 484022005251 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 484022005252 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 484022005253 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 484022005254 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 484022005255 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 484022005256 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 484022005257 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 484022005258 putative active site [active] 484022005259 catalytic site [active] 484022005260 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 484022005261 putative active site [active] 484022005262 catalytic site [active] 484022005263 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 484022005264 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 484022005265 putative active site [active] 484022005266 catalytic site [active] 484022005267 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 484022005268 putative active site [active] 484022005269 catalytic site [active] 484022005270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005271 metabolite-proton symporter; Region: 2A0106; TIGR00883 484022005272 putative substrate translocation pore; other site 484022005273 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 484022005274 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 484022005275 Walker A motif; other site 484022005276 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 484022005277 trimer interface [polypeptide binding]; other site 484022005278 active site 484022005279 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 484022005280 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022005281 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022005282 Integrase core domain; Region: rve; pfam00665 484022005283 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 484022005284 multiple promoter invertase; Provisional; Region: mpi; PRK13413 484022005285 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 484022005286 catalytic residues [active] 484022005287 catalytic nucleophile [active] 484022005288 Presynaptic Site I dimer interface [polypeptide binding]; other site 484022005289 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 484022005290 Synaptic Flat tetramer interface [polypeptide binding]; other site 484022005291 Synaptic Site I dimer interface [polypeptide binding]; other site 484022005292 DNA binding site [nucleotide binding] 484022005293 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 484022005294 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 484022005295 ArsC family; Region: ArsC; pfam03960 484022005296 catalytic residues [active] 484022005297 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 484022005298 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 484022005299 Sulfate transporter family; Region: Sulfate_transp; pfam00916 484022005300 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 484022005301 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 484022005302 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484022005303 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022005304 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022005305 Integrase core domain; Region: rve; pfam00665 484022005306 Lipopolysaccharide-assembly; Region: LptE; cl01125 484022005307 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 484022005308 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 484022005309 HIGH motif; other site 484022005310 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 484022005311 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022005312 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484022005313 active site 484022005314 KMSKS motif; other site 484022005315 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 484022005316 tRNA binding surface [nucleotide binding]; other site 484022005317 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 484022005318 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 484022005319 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 484022005320 active site 484022005321 8-oxo-dGMP binding site [chemical binding]; other site 484022005322 nudix motif; other site 484022005323 metal binding site [ion binding]; metal-binding site 484022005324 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 484022005325 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 484022005326 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 484022005327 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 484022005328 catalytic residues [active] 484022005329 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 484022005330 FeS assembly protein SufD; Region: sufD; TIGR01981 484022005331 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 484022005332 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 484022005333 Walker A/P-loop; other site 484022005334 ATP binding site [chemical binding]; other site 484022005335 Q-loop/lid; other site 484022005336 ABC transporter signature motif; other site 484022005337 Walker B; other site 484022005338 D-loop; other site 484022005339 H-loop/switch region; other site 484022005340 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 484022005341 putative ABC transporter; Region: ycf24; CHL00085 484022005342 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 484022005343 Transcriptional regulator; Region: Rrf2; pfam02082 484022005344 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 484022005345 TrkA-N domain; Region: TrkA_N; pfam02254 484022005346 TrkA-C domain; Region: TrkA_C; pfam02080 484022005347 TrkA-N domain; Region: TrkA_N; pfam02254 484022005348 TrkA-C domain; Region: TrkA_C; pfam02080 484022005349 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 484022005350 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 484022005351 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 484022005352 rRNA binding site [nucleotide binding]; other site 484022005353 predicted 30S ribosome binding site; other site 484022005354 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 484022005355 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 484022005356 signal recognition particle protein; Provisional; Region: PRK10867 484022005357 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 484022005358 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 484022005359 P loop; other site 484022005360 GTP binding site [chemical binding]; other site 484022005361 Signal peptide binding domain; Region: SRP_SPB; pfam02978 484022005362 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 484022005363 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 484022005364 Bor protein; Region: Lambda_Bor; pfam06291 484022005365 Bor protein; Region: Lambda_Bor; pfam06291 484022005366 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 484022005367 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 484022005368 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 484022005369 active site 484022005370 Zn binding site [ion binding]; other site 484022005371 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 484022005372 putative active site [active] 484022005373 putative catalytic site [active] 484022005374 putative DNA binding site [nucleotide binding]; other site 484022005375 putative phosphate binding site [ion binding]; other site 484022005376 metal binding site A [ion binding]; metal-binding site 484022005377 putative AP binding site [nucleotide binding]; other site 484022005378 putative metal binding site B [ion binding]; other site 484022005379 Nuclease-related domain; Region: NERD; pfam08378 484022005380 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 484022005381 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 484022005382 glutathione reductase; Validated; Region: PRK06116 484022005383 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484022005384 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484022005385 Uncharacterized conserved protein [Function unknown]; Region: COG0393 484022005386 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 484022005387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005388 putative substrate translocation pore; other site 484022005389 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 484022005390 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 484022005391 ATP binding site [chemical binding]; other site 484022005392 Mg++ binding site [ion binding]; other site 484022005393 motif III; other site 484022005394 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022005395 nucleotide binding region [chemical binding]; other site 484022005396 ATP-binding site [chemical binding]; other site 484022005397 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 484022005398 GTP cyclohydrolase I; Provisional; Region: PLN03044 484022005399 active site 484022005400 Uncharacterized conserved protein [Function unknown]; Region: COG1434 484022005401 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 484022005402 putative active site [active] 484022005403 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 484022005404 Predicted amidohydrolase [General function prediction only]; Region: COG0388 484022005405 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 484022005406 active site 484022005407 catalytic triad [active] 484022005408 dimer interface [polypeptide binding]; other site 484022005409 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484022005410 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484022005411 active site 484022005412 catalytic tetrad [active] 484022005413 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484022005414 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484022005415 active site 484022005416 catalytic tetrad [active] 484022005417 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484022005418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005419 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 484022005420 Glutamine amidotransferase class-I; Region: GATase; pfam00117 484022005421 glutamine binding [chemical binding]; other site 484022005422 catalytic triad [active] 484022005423 chorismate binding enzyme; Region: Chorismate_bind; cl10555 484022005424 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 484022005425 Aminotransferase class IV; Region: Aminotran_4; pfam01063 484022005426 substrate-cofactor binding pocket; other site 484022005427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022005428 homodimer interface [polypeptide binding]; other site 484022005429 catalytic residue [active] 484022005430 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 484022005431 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 484022005432 acyl-activating enzyme (AAE) consensus motif; other site 484022005433 AMP binding site [chemical binding]; other site 484022005434 active site 484022005435 CoA binding site [chemical binding]; other site 484022005436 Dihydroneopterin aldolase; Region: FolB; smart00905 484022005437 active site 484022005438 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 484022005439 catalytic center binding site [active] 484022005440 ATP binding site [chemical binding]; other site 484022005441 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 484022005442 dihydropteroate synthase; Region: DHPS; TIGR01496 484022005443 substrate binding pocket [chemical binding]; other site 484022005444 dimer interface [polypeptide binding]; other site 484022005445 inhibitor binding site; inhibition site 484022005446 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 484022005447 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 484022005448 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557 484022005449 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484022005450 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 484022005451 inhibitor-cofactor binding pocket; inhibition site 484022005452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022005453 catalytic residue [active] 484022005454 biotin synthase; Region: bioB; TIGR00433 484022005455 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484022005456 FeS/SAM binding site; other site 484022005457 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 484022005458 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 484022005459 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 484022005460 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022005461 catalytic residue [active] 484022005462 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 484022005463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022005464 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 484022005465 AAA domain; Region: AAA_26; pfam13500 484022005466 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484022005467 dimerization interface [polypeptide binding]; other site 484022005468 putative DNA binding site [nucleotide binding]; other site 484022005469 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 484022005470 putative Zn2+ binding site [ion binding]; other site 484022005471 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 484022005472 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484022005473 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484022005474 nucleotide binding site [chemical binding]; other site 484022005475 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 484022005476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005477 putative substrate translocation pore; other site 484022005478 acetoacetate decarboxylase; Provisional; Region: PRK02265 484022005479 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 484022005480 classical (c) SDRs; Region: SDR_c; cd05233 484022005481 NAD(P) binding site [chemical binding]; other site 484022005482 active site 484022005483 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 484022005484 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 484022005485 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 484022005486 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 484022005487 heme-binding site [chemical binding]; other site 484022005488 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 484022005489 FAD binding pocket [chemical binding]; other site 484022005490 FAD binding motif [chemical binding]; other site 484022005491 phosphate binding motif [ion binding]; other site 484022005492 beta-alpha-beta structure motif; other site 484022005493 NAD binding pocket [chemical binding]; other site 484022005494 Heme binding pocket [chemical binding]; other site 484022005495 Transcriptional regulator; Region: Rrf2; cl17282 484022005496 Rrf2 family protein; Region: rrf2_super; TIGR00738 484022005497 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 484022005498 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 484022005499 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 484022005500 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484022005501 inhibitor-cofactor binding pocket; inhibition site 484022005502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484022005503 catalytic residue [active] 484022005504 glutathione synthetase; Provisional; Region: PRK05246 484022005505 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 484022005506 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 484022005507 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 484022005508 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 484022005509 putative active site [active] 484022005510 substrate binding site [chemical binding]; other site 484022005511 putative cosubstrate binding site; other site 484022005512 catalytic site [active] 484022005513 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 484022005514 substrate binding site [chemical binding]; other site 484022005515 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484022005516 dimerization interface [polypeptide binding]; other site 484022005517 putative DNA binding site [nucleotide binding]; other site 484022005518 putative Zn2+ binding site [ion binding]; other site 484022005519 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 484022005520 arsenical-resistance protein; Region: acr3; TIGR00832 484022005521 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 484022005522 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 484022005523 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 484022005524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 484022005525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022005526 S-adenosylmethionine binding site [chemical binding]; other site 484022005527 integrase; Provisional; Region: PRK09692 484022005528 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 484022005529 active site 484022005530 Int/Topo IB signature motif; other site 484022005531 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 484022005532 Methyltransferase domain; Region: Methyltransf_26; pfam13659 484022005533 Virulence protein [General function prediction only]; Region: COG3943 484022005534 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 484022005535 DEAD-like helicases superfamily; Region: DEXDc; smart00487 484022005536 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022005537 ATP binding site [chemical binding]; other site 484022005538 putative Mg++ binding site [ion binding]; other site 484022005539 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 484022005540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484022005541 non-specific DNA binding site [nucleotide binding]; other site 484022005542 salt bridge; other site 484022005543 sequence-specific DNA binding site [nucleotide binding]; other site 484022005544 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 484022005545 Antirestriction protein (ArdA); Region: ArdA; pfam07275 484022005546 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 484022005547 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 484022005548 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 484022005549 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 484022005550 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484022005551 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484022005552 non-specific DNA binding site [nucleotide binding]; other site 484022005553 salt bridge; other site 484022005554 sequence-specific DNA binding site [nucleotide binding]; other site 484022005555 recombination associated protein; Reviewed; Region: rdgC; PRK00321 484022005556 Cyclic phosphodiesterase-like protein; Region: CPDase; pfam07823 484022005557 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 484022005558 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 484022005559 active site residue [active] 484022005560 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 484022005561 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 484022005562 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 484022005563 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484022005564 catalytic residue [active] 484022005565 cytidylate kinase; Provisional; Region: cmk; PRK00023 484022005566 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 484022005567 CMP-binding site; other site 484022005568 The sites determining sugar specificity; other site 484022005569 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 484022005570 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 484022005571 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 484022005572 L-aspartate oxidase; Provisional; Region: PRK09077 484022005573 L-aspartate oxidase; Provisional; Region: PRK06175 484022005574 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 484022005575 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 484022005576 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 484022005577 dimerization interface [polypeptide binding]; other site 484022005578 active site 484022005579 quinolinate synthetase; Provisional; Region: PRK09375 484022005580 Guanylate kinase; Region: Guanylate_kin; pfam00625 484022005581 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 484022005582 catalytic site [active] 484022005583 G-X2-G-X-G-K; other site 484022005584 helicase 45; Provisional; Region: PTZ00424 484022005585 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 484022005586 ATP binding site [chemical binding]; other site 484022005587 Mg++ binding site [ion binding]; other site 484022005588 motif III; other site 484022005589 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484022005590 nucleotide binding region [chemical binding]; other site 484022005591 ATP-binding site [chemical binding]; other site 484022005592 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 484022005593 putative RNA binding site [nucleotide binding]; other site 484022005594 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 484022005595 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 484022005596 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 484022005597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005598 putative substrate translocation pore; other site 484022005599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005600 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 484022005601 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 484022005602 dimer interface [polypeptide binding]; other site 484022005603 active site 484022005604 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 484022005605 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 484022005606 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 484022005607 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 484022005608 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022005609 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022005610 Integrase core domain; Region: rve; pfam00665 484022005611 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 484022005612 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 484022005613 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 484022005614 Ligand binding site; other site 484022005615 oligomer interface; other site 484022005616 Uncharacterized conserved protein [Function unknown]; Region: COG2835 484022005617 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 484022005618 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 484022005619 Ligand Binding Site [chemical binding]; other site 484022005620 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 484022005621 CPxP motif; other site 484022005622 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 484022005623 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 484022005624 active site 484022005625 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 484022005626 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 484022005627 GIY-YIG motif/motif A; other site 484022005628 active site 484022005629 catalytic site [active] 484022005630 putative DNA binding site [nucleotide binding]; other site 484022005631 metal binding site [ion binding]; metal-binding site 484022005632 UvrB/uvrC motif; Region: UVR; pfam02151 484022005633 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 484022005634 ribonuclease D; Region: rnd; TIGR01388 484022005635 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 484022005636 catalytic site [active] 484022005637 putative active site [active] 484022005638 putative substrate binding site [chemical binding]; other site 484022005639 HRDC domain; Region: HRDC; pfam00570 484022005640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005641 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 484022005642 putative substrate translocation pore; other site 484022005643 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 484022005644 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 484022005645 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 484022005646 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 484022005647 active site 484022005648 recombination protein F; Reviewed; Region: recF; PRK00064 484022005649 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484022005650 Walker A/P-loop; other site 484022005651 ATP binding site [chemical binding]; other site 484022005652 Q-loop/lid; other site 484022005653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484022005654 ABC transporter signature motif; other site 484022005655 Walker B; other site 484022005656 D-loop; other site 484022005657 H-loop/switch region; other site 484022005658 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 484022005659 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 484022005660 EamA-like transporter family; Region: EamA; pfam00892 484022005661 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 484022005662 EamA-like transporter family; Region: EamA; pfam00892 484022005663 acetyl-CoA synthetase; Provisional; Region: PRK00174 484022005664 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 484022005665 active site 484022005666 CoA binding site [chemical binding]; other site 484022005667 acyl-activating enzyme (AAE) consensus motif; other site 484022005668 AMP binding site [chemical binding]; other site 484022005669 acetate binding site [chemical binding]; other site 484022005670 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 484022005671 active site 484022005672 tetramer interface; other site 484022005673 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 484022005674 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 484022005675 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022005676 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022005677 Integrase core domain; Region: rve; pfam00665 484022005678 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 484022005679 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022005680 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022005681 Integrase core domain; Region: rve; pfam00665 484022005682 Restriction endonuclease [Defense mechanisms]; Region: COG3587 484022005683 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484022005684 ATP binding site [chemical binding]; other site 484022005685 putative Mg++ binding site [ion binding]; other site 484022005686 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 484022005687 GIY-YIG motif/motif A; other site 484022005688 putative active site [active] 484022005689 putative metal binding site [ion binding]; other site 484022005690 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484022005691 Helix-turn-helix domain; Region: HTH_38; pfam13936 484022005692 Integrase core domain; Region: rve; pfam00665 484022005693 Antirestriction protein (ArdA); Region: ArdA; pfam07275 484022005694 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 484022005695 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 484022005696 FMN binding site [chemical binding]; other site 484022005697 active site 484022005698 catalytic residues [active] 484022005699 substrate binding site [chemical binding]; other site 484022005700 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 484022005701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484022005702 S-adenosylmethionine binding site [chemical binding]; other site 484022005703 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 484022005704 ferrochelatase; Reviewed; Region: hemH; PRK00035 484022005705 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 484022005706 C-terminal domain interface [polypeptide binding]; other site 484022005707 active site 484022005708 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 484022005709 active site 484022005710 N-terminal domain interface [polypeptide binding]; other site 484022005711 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 484022005712 DNA photolyase; Region: DNA_photolyase; pfam00875 484022005713 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 484022005714 Enolase, C-terminal TIM barrel domain; Region: Enolase_C; pfam00113 484022005715 substrate binding pocket [chemical binding]; other site 484022005716 dimer interface [polypeptide binding]; other site 484022005717 metal binding site [ion binding]; metal-binding site 484022005718 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 484022005719 active site 484022005720 catalytic residues [active] 484022005721 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 484022005722 Flavoprotein; Region: Flavoprotein; pfam02441 484022005723 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 484022005724 benzoate transport; Region: 2A0115; TIGR00895 484022005725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484022005726 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 484022005727 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 484022005728 Proline dehydrogenase; Region: Pro_dh; pfam01619 484022005729 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 484022005730 Glutamate binding site [chemical binding]; other site 484022005731 NAD binding site [chemical binding]; other site 484022005732 catalytic residues [active] 484022005733 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 484022005734 NAD(P) binding site [chemical binding]; other site 484022005735 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 484022005736 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 484022005737 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 484022005738 metal binding site [ion binding]; metal-binding site