-- dump date 20140619_095500 -- class Genbank::misc_feature -- table misc_feature_note -- id note 510831000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 510831000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 510831000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 510831000004 Walker A motif; other site 510831000005 ATP binding site [chemical binding]; other site 510831000006 Walker B motif; other site 510831000007 arginine finger; other site 510831000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 510831000009 DnaA box-binding interface [nucleotide binding]; other site 510831000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 510831000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 510831000012 putative DNA binding surface [nucleotide binding]; other site 510831000013 dimer interface [polypeptide binding]; other site 510831000014 beta-clamp/clamp loader binding surface; other site 510831000015 beta-clamp/translesion DNA polymerase binding surface; other site 510831000016 metabolite-proton symporter; Region: 2A0106; TIGR00883 510831000017 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831000018 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831000019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831000020 Winged helix-turn helix; Region: HTH_29; pfam13551 510831000021 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 510831000022 metabolite-proton symporter; Region: 2A0106; TIGR00883 510831000023 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 510831000024 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 510831000025 dimer interface [polypeptide binding]; other site 510831000026 anticodon binding site; other site 510831000027 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 510831000028 homodimer interface [polypeptide binding]; other site 510831000029 motif 1; other site 510831000030 active site 510831000031 motif 2; other site 510831000032 GAD domain; Region: GAD; pfam02938 510831000033 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 510831000034 active site 510831000035 motif 3; other site 510831000036 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 510831000037 Winged helix-turn helix; Region: HTH_29; pfam13551 510831000038 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831000039 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 510831000040 potential frameshift: common BLAST hit: gi|268680340|ref|YP_003304771.1| type II site-specific deoxyribonuclease 510831000041 NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521 510831000042 NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521 510831000043 potential frameshift: common BLAST hit: gi|169656773|ref|YP_001429391.2| aldose 1-epimerase family protein [Francisella tularensis subsp. 510831000044 adenylosuccinate lyase; Provisional; Region: PRK07492 510831000045 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 510831000046 tetramer interface [polypeptide binding]; other site 510831000047 active site 510831000048 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 510831000049 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 510831000050 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 510831000051 HlyD family secretion protein; Region: HlyD_3; pfam13437 510831000052 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 510831000053 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 510831000054 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 510831000055 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 510831000056 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 510831000057 GatB domain; Region: GatB_Yqey; smart00845 510831000058 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 510831000059 oxyanion hole [active] 510831000060 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 510831000061 catalytic triad [active] 510831000062 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 510831000063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831000064 putative substrate translocation pore; other site 510831000065 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 510831000066 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 510831000067 dimer interface [polypeptide binding]; other site 510831000068 active site 510831000069 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 510831000070 catalytic residues [active] 510831000071 substrate binding site [chemical binding]; other site 510831000072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 510831000073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831000074 IucA / IucC family; Region: IucA_IucC; pfam04183 510831000075 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 510831000076 ferric uptake regulator; Provisional; Region: fur; PRK09462 510831000077 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 510831000078 metal binding site 2 [ion binding]; metal-binding site 510831000079 putative DNA binding helix; other site 510831000080 metal binding site 1 [ion binding]; metal-binding site 510831000081 dimer interface [polypeptide binding]; other site 510831000082 structural Zn2+ binding site [ion binding]; other site 510831000083 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 510831000084 NADH dehydrogenase subunit B; Validated; Region: PRK06411 510831000085 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 510831000086 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 510831000087 NADH dehydrogenase subunit D; Validated; Region: PRK06075 510831000088 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 510831000089 NADH dehydrogenase subunit E; Validated; Region: PRK07539 510831000090 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 510831000091 putative dimer interface [polypeptide binding]; other site 510831000092 [2Fe-2S] cluster binding site [ion binding]; other site 510831000093 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 510831000094 SLBB domain; Region: SLBB; pfam10531 510831000095 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 510831000096 NADH dehydrogenase subunit G; Validated; Region: PRK09129 510831000097 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 510831000098 catalytic loop [active] 510831000099 iron binding site [ion binding]; other site 510831000100 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 510831000101 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 510831000102 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 510831000103 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 510831000104 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 510831000105 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 510831000106 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 510831000107 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 510831000108 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 510831000109 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 510831000110 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 510831000111 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 510831000112 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 510831000113 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 510831000114 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 510831000115 Membrane fusogenic activity; Region: BMFP; pfam04380 510831000116 potential frameshift: common BLAST hit: gi|118498226|ref|YP_899276.1| magnesium chelatase 510831000117 potential frameshift: common BLAST hit: gi|118498226|ref|YP_899276.1| magnesium chelatase 510831000118 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 510831000119 substrate binding site [chemical binding]; other site 510831000120 active site 510831000121 ribosome maturation protein RimP; Reviewed; Region: PRK00092 510831000122 hypothetical protein; Provisional; Region: PRK14641 510831000123 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 510831000124 putative oligomer interface [polypeptide binding]; other site 510831000125 putative RNA binding site [nucleotide binding]; other site 510831000126 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 510831000127 NusA N-terminal domain; Region: NusA_N; pfam08529 510831000128 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 510831000129 RNA binding site [nucleotide binding]; other site 510831000130 homodimer interface [polypeptide binding]; other site 510831000131 NusA-like KH domain; Region: KH_5; pfam13184 510831000132 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 510831000133 G-X-X-G motif; other site 510831000134 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 510831000135 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 510831000136 translation initiation factor IF-2; Region: IF-2; TIGR00487 510831000137 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 510831000138 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 510831000139 G1 box; other site 510831000140 putative GEF interaction site [polypeptide binding]; other site 510831000141 GTP/Mg2+ binding site [chemical binding]; other site 510831000142 Switch I region; other site 510831000143 G2 box; other site 510831000144 G3 box; other site 510831000145 Switch II region; other site 510831000146 G4 box; other site 510831000147 G5 box; other site 510831000148 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 510831000149 Translation-initiation factor 2; Region: IF-2; pfam11987 510831000150 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 510831000151 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 510831000152 histidyl-tRNA synthetase; Region: hisS; TIGR00442 510831000153 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 510831000154 dimer interface [polypeptide binding]; other site 510831000155 motif 1; other site 510831000156 active site 510831000157 motif 2; other site 510831000158 motif 3; other site 510831000159 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 510831000160 anticodon binding site; other site 510831000161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831000162 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 510831000163 putative substrate translocation pore; other site 510831000164 Predicted ATPase [General function prediction only]; Region: COG1485 510831000165 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 510831000166 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 510831000167 RNA binding surface [nucleotide binding]; other site 510831000168 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 510831000169 active site 510831000170 Major Facilitator Superfamily; Region: MFS_1; pfam07690 510831000171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831000172 putative substrate translocation pore; other site 510831000173 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 510831000174 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 510831000175 F0F1 ATP synthase subunit C; Provisional; Region: PRK13464 510831000176 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 510831000177 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 510831000178 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 510831000179 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 510831000180 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 510831000181 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 510831000182 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 510831000183 beta subunit interaction interface [polypeptide binding]; other site 510831000184 Walker A motif; other site 510831000185 ATP binding site [chemical binding]; other site 510831000186 Walker B motif; other site 510831000187 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 510831000188 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 510831000189 core domain interface [polypeptide binding]; other site 510831000190 delta subunit interface [polypeptide binding]; other site 510831000191 epsilon subunit interface [polypeptide binding]; other site 510831000192 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 510831000193 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 510831000194 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 510831000195 alpha subunit interaction interface [polypeptide binding]; other site 510831000196 Walker A motif; other site 510831000197 ATP binding site [chemical binding]; other site 510831000198 Walker B motif; other site 510831000199 inhibitor binding site; inhibition site 510831000200 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 510831000201 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 510831000202 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 510831000203 gamma subunit interface [polypeptide binding]; other site 510831000204 epsilon subunit interface [polypeptide binding]; other site 510831000205 LBP interface [polypeptide binding]; other site 510831000206 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 510831000207 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 510831000208 putative active site [active] 510831000209 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 510831000210 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 510831000211 putative GSH binding site [chemical binding]; other site 510831000212 catalytic residues [active] 510831000213 superoxide dismutase; Provisional; Region: PRK10543 510831000214 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 510831000215 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 510831000216 muropeptide transporter; Reviewed; Region: ampG; PRK11902 510831000217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831000218 putative substrate translocation pore; other site 510831000219 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 510831000220 dimer interface [polypeptide binding]; other site 510831000221 Citrate synthase; Region: Citrate_synt; pfam00285 510831000222 active site 510831000223 citrylCoA binding site [chemical binding]; other site 510831000224 NADH binding [chemical binding]; other site 510831000225 cationic pore residues; other site 510831000226 oxalacetate/citrate binding site [chemical binding]; other site 510831000227 coenzyme A binding site [chemical binding]; other site 510831000228 catalytic triad [active] 510831000229 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 510831000230 Iron-sulfur protein interface; other site 510831000231 proximal quinone binding site [chemical binding]; other site 510831000232 SdhD (CybS) interface [polypeptide binding]; other site 510831000233 proximal heme binding site [chemical binding]; other site 510831000234 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 510831000235 SdhC subunit interface [polypeptide binding]; other site 510831000236 proximal heme binding site [chemical binding]; other site 510831000237 cardiolipin binding site; other site 510831000238 Iron-sulfur protein interface; other site 510831000239 proximal quinone binding site [chemical binding]; other site 510831000240 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 510831000241 L-aspartate oxidase; Provisional; Region: PRK06175 510831000242 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 510831000243 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 510831000244 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 510831000245 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 510831000246 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 510831000247 TPP-binding site [chemical binding]; other site 510831000248 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 510831000249 dimer interface [polypeptide binding]; other site 510831000250 PYR/PP interface [polypeptide binding]; other site 510831000251 TPP binding site [chemical binding]; other site 510831000252 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 510831000253 E3 interaction surface; other site 510831000254 lipoyl attachment site [posttranslational modification]; other site 510831000255 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 510831000256 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 510831000257 E3 interaction surface; other site 510831000258 lipoyl attachment site [posttranslational modification]; other site 510831000259 e3 binding domain; Region: E3_binding; pfam02817 510831000260 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 510831000261 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 510831000262 nucleotide binding site [chemical binding]; other site 510831000263 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 510831000264 active site 510831000265 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 510831000266 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 510831000267 active site 510831000268 substrate binding site [chemical binding]; other site 510831000269 metal binding site [ion binding]; metal-binding site 510831000270 triosephosphate isomerase; Provisional; Region: PRK14567 510831000271 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 510831000272 substrate binding site [chemical binding]; other site 510831000273 dimer interface [polypeptide binding]; other site 510831000274 catalytic triad [active] 510831000275 Preprotein translocase SecG subunit; Region: SecG; pfam03840 510831000276 Transcriptional regulator [Transcription]; Region: LysR; COG0583 510831000277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 510831000278 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 510831000279 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 510831000280 HemN family oxidoreductase; Provisional; Region: PRK05660 510831000281 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 510831000282 FeS/SAM binding site; other site 510831000283 HemN C-terminal domain; Region: HemN_C; pfam06969 510831000284 Predicted membrane protein [Function unknown]; Region: COG2246 510831000285 GtrA-like protein; Region: GtrA; pfam04138 510831000286 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 510831000287 aconitate hydratase; Validated; Region: PRK09277 510831000288 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 510831000289 substrate binding site [chemical binding]; other site 510831000290 ligand binding site [chemical binding]; other site 510831000291 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 510831000292 substrate binding site [chemical binding]; other site 510831000293 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 510831000294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 510831000295 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 510831000296 Walker A motif; other site 510831000297 Walker A/P-loop; other site 510831000298 ATP binding site [chemical binding]; other site 510831000299 ATP binding site [chemical binding]; other site 510831000300 Walker B motif; other site 510831000301 potential frameshift: common BLAST hit: gi|118498184|ref|YP_899234.1| predicted NAD/FAD-dependent oxidoreductase 510831000302 potential frameshift: common BLAST hit: gi|118498184|ref|YP_899234.1| predicted NAD/FAD-dependent oxidoreductase 510831000303 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 510831000304 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 510831000305 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 510831000306 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 510831000307 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 510831000308 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 510831000309 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 510831000310 putative NAD(P) binding site [chemical binding]; other site 510831000311 putative active site [active] 510831000312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 510831000313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 510831000314 dimer interface [polypeptide binding]; other site 510831000315 phosphorylation site [posttranslational modification] 510831000316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 510831000317 ATP binding site [chemical binding]; other site 510831000318 Mg2+ binding site [ion binding]; other site 510831000319 G-X-G motif; other site 510831000320 ATP-grasp domain; Region: ATP-grasp_4; cl17255 510831000321 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831000322 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831000323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831000324 Winged helix-turn helix; Region: HTH_29; pfam13551 510831000325 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 510831000326 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831000327 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831000328 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 510831000329 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 510831000330 dimer interface [polypeptide binding]; other site 510831000331 catalytic triad [active] 510831000332 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 510831000333 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 510831000334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831000335 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 510831000336 multidrug efflux protein; Reviewed; Region: PRK09579 510831000337 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 510831000338 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 510831000339 HlyD family secretion protein; Region: HlyD_3; pfam13437 510831000340 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 510831000341 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 510831000342 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 510831000343 active site 510831000344 NTP binding site [chemical binding]; other site 510831000345 metal binding triad [ion binding]; metal-binding site 510831000346 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 510831000347 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 510831000348 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 510831000349 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 510831000350 Walker A/P-loop; other site 510831000351 ATP binding site [chemical binding]; other site 510831000352 Q-loop/lid; other site 510831000353 ABC transporter signature motif; other site 510831000354 Walker B; other site 510831000355 D-loop; other site 510831000356 H-loop/switch region; other site 510831000357 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 510831000358 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 510831000359 DNA polymerase I; Provisional; Region: PRK05755 510831000360 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 510831000361 active site 510831000362 metal binding site 1 [ion binding]; metal-binding site 510831000363 putative 5' ssDNA interaction site; other site 510831000364 metal binding site 3; metal-binding site 510831000365 metal binding site 2 [ion binding]; metal-binding site 510831000366 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 510831000367 putative DNA binding site [nucleotide binding]; other site 510831000368 putative metal binding site [ion binding]; other site 510831000369 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 510831000370 active site 510831000371 catalytic site [active] 510831000372 substrate binding site [chemical binding]; other site 510831000373 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 510831000374 active site 510831000375 DNA binding site [nucleotide binding] 510831000376 catalytic site [active] 510831000377 pantothenate kinase; Reviewed; Region: PRK13324 510831000378 phosphopentomutase; Provisional; Region: PRK05362 510831000379 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 510831000380 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 510831000381 intersubunit interface [polypeptide binding]; other site 510831000382 active site 510831000383 catalytic residue [active] 510831000384 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 510831000385 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 510831000386 Nucleoside recognition; Region: Gate; pfam07670 510831000387 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 510831000388 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 510831000389 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 510831000390 Nucleoside recognition; Region: Gate; pfam07670 510831000391 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 510831000392 thymidylate kinase; Validated; Region: tmk; PRK00698 510831000393 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 510831000394 TMP-binding site; other site 510831000395 ATP-binding site [chemical binding]; other site 510831000396 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 510831000397 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 510831000398 G1 box; other site 510831000399 putative GEF interaction site [polypeptide binding]; other site 510831000400 GTP/Mg2+ binding site [chemical binding]; other site 510831000401 Switch I region; other site 510831000402 G2 box; other site 510831000403 G3 box; other site 510831000404 Switch II region; other site 510831000405 G4 box; other site 510831000406 G5 box; other site 510831000407 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 510831000408 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 510831000409 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 510831000410 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 510831000411 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 510831000412 GTP binding site [chemical binding]; other site 510831000413 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 510831000414 Part of AAA domain; Region: AAA_19; pfam13245 510831000415 Family description; Region: UvrD_C_2; pfam13538 510831000416 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 510831000417 peptide binding site [polypeptide binding]; other site 510831000418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 510831000419 dimer interface [polypeptide binding]; other site 510831000420 conserved gate region; other site 510831000421 putative PBP binding loops; other site 510831000422 ABC-ATPase subunit interface; other site 510831000423 potential frameshift: common BLAST hit: gi|167627251|ref|YP_001677751.1| peptide/opine/nickel uptake transporter (PepT) family protein 510831000424 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 510831000425 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 510831000426 Walker A/P-loop; other site 510831000427 ATP binding site [chemical binding]; other site 510831000428 Q-loop/lid; other site 510831000429 ABC transporter signature motif; other site 510831000430 Walker B; other site 510831000431 D-loop; other site 510831000432 H-loop/switch region; other site 510831000433 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 510831000434 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 510831000435 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 510831000436 Walker A/P-loop; other site 510831000437 ATP binding site [chemical binding]; other site 510831000438 Q-loop/lid; other site 510831000439 ABC transporter signature motif; other site 510831000440 Walker B; other site 510831000441 D-loop; other site 510831000442 H-loop/switch region; other site 510831000443 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 510831000444 Major Facilitator Superfamily; Region: MFS_1; pfam07690 510831000445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831000446 putative substrate translocation pore; other site 510831000447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831000448 putative substrate translocation pore; other site 510831000449 Major Facilitator Superfamily; Region: MFS_1; pfam07690 510831000450 glycerol kinase; Provisional; Region: glpK; PRK00047 510831000451 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 510831000452 N- and C-terminal domain interface [polypeptide binding]; other site 510831000453 active site 510831000454 MgATP binding site [chemical binding]; other site 510831000455 catalytic site [active] 510831000456 metal binding site [ion binding]; metal-binding site 510831000457 glycerol binding site [chemical binding]; other site 510831000458 homotetramer interface [polypeptide binding]; other site 510831000459 homodimer interface [polypeptide binding]; other site 510831000460 FBP binding site [chemical binding]; other site 510831000461 protein IIAGlc interface [polypeptide binding]; other site 510831000462 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831000463 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831000464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831000465 Winged helix-turn helix; Region: HTH_29; pfam13551 510831000466 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 510831000467 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 510831000468 amphipathic channel; other site 510831000469 Asn-Pro-Ala signature motifs; other site 510831000470 Mechanosensitive ion channel; Region: MS_channel; pfam00924 510831000471 AAA domain; Region: AAA_30; pfam13604 510831000472 Family description; Region: UvrD_C_2; pfam13538 510831000473 elongation factor Tu; Reviewed; Region: PRK00049 510831000474 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 510831000475 G1 box; other site 510831000476 GEF interaction site [polypeptide binding]; other site 510831000477 GTP/Mg2+ binding site [chemical binding]; other site 510831000478 Switch I region; other site 510831000479 G2 box; other site 510831000480 G3 box; other site 510831000481 Switch II region; other site 510831000482 G4 box; other site 510831000483 G5 box; other site 510831000484 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 510831000485 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 510831000486 Antibiotic Binding Site [chemical binding]; other site 510831000487 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 510831000488 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 510831000489 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 510831000490 putative homodimer interface [polypeptide binding]; other site 510831000491 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 510831000492 heterodimer interface [polypeptide binding]; other site 510831000493 homodimer interface [polypeptide binding]; other site 510831000494 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 510831000495 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 510831000496 23S rRNA interface [nucleotide binding]; other site 510831000497 L7/L12 interface [polypeptide binding]; other site 510831000498 putative thiostrepton binding site; other site 510831000499 L25 interface [polypeptide binding]; other site 510831000500 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 510831000501 mRNA/rRNA interface [nucleotide binding]; other site 510831000502 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 510831000503 23S rRNA interface [nucleotide binding]; other site 510831000504 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 510831000505 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 510831000506 core dimer interface [polypeptide binding]; other site 510831000507 peripheral dimer interface [polypeptide binding]; other site 510831000508 L10 interface [polypeptide binding]; other site 510831000509 L11 interface [polypeptide binding]; other site 510831000510 putative EF-Tu interaction site [polypeptide binding]; other site 510831000511 putative EF-G interaction site [polypeptide binding]; other site 510831000512 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 510831000513 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 510831000514 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 510831000515 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 510831000516 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 510831000517 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 510831000518 RPB3 interaction site [polypeptide binding]; other site 510831000519 RPB1 interaction site [polypeptide binding]; other site 510831000520 RPB11 interaction site [polypeptide binding]; other site 510831000521 RPB10 interaction site [polypeptide binding]; other site 510831000522 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 510831000523 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 510831000524 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 510831000525 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 510831000526 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 510831000527 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 510831000528 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 510831000529 cleft; other site 510831000530 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 510831000531 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 510831000532 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 510831000533 DNA binding site [nucleotide binding] 510831000534 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 510831000535 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 510831000536 UGMP family protein; Validated; Region: PRK09604 510831000537 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 510831000538 Fatty acid desaturase; Region: FA_desaturase; pfam00487 510831000539 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 510831000540 Di-iron ligands [ion binding]; other site 510831000541 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 510831000542 S-adenosylmethionine synthetase; Validated; Region: PRK05250 510831000543 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 510831000544 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 510831000545 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 510831000546 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 510831000547 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 510831000548 RimM N-terminal domain; Region: RimM; pfam01782 510831000549 PRC-barrel domain; Region: PRC; pfam05239 510831000550 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 510831000551 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 510831000552 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 510831000553 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 510831000554 active site 510831000555 DNA binding site [nucleotide binding] 510831000556 Int/Topo IB signature motif; other site 510831000557 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 510831000558 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 510831000559 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 510831000560 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 510831000561 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 510831000562 putative active site [active] 510831000563 Ap4A binding site [chemical binding]; other site 510831000564 nudix motif; other site 510831000565 putative metal binding site [ion binding]; other site 510831000566 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 510831000567 active site 510831000568 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 510831000569 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 510831000570 amidase catalytic site [active] 510831000571 Zn binding residues [ion binding]; other site 510831000572 substrate binding site [chemical binding]; other site 510831000573 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 510831000574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 510831000575 Mg2+ binding site [ion binding]; other site 510831000576 G-X-G motif; other site 510831000577 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 510831000578 anchoring element; other site 510831000579 dimer interface [polypeptide binding]; other site 510831000580 ATP binding site [chemical binding]; other site 510831000581 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 510831000582 active site 510831000583 metal binding site [ion binding]; metal-binding site 510831000584 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 510831000585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831000586 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 510831000587 putative substrate translocation pore; other site 510831000588 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 510831000589 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 510831000590 Trp docking motif [polypeptide binding]; other site 510831000591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 510831000592 TPR motif; other site 510831000593 binding surface 510831000594 Tetratricopeptide repeat; Region: TPR_16; pfam13432 510831000595 glutamyl-tRNA reductase; Provisional; Region: PRK13940 510831000596 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 510831000597 tRNA; other site 510831000598 putative tRNA binding site [nucleotide binding]; other site 510831000599 putative NADP binding site [chemical binding]; other site 510831000600 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 510831000601 peptide chain release factor 1; Validated; Region: prfA; PRK00591 510831000602 This domain is found in peptide chain release factors; Region: PCRF; smart00937 510831000603 RF-1 domain; Region: RF-1; pfam00472 510831000604 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 510831000605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 510831000606 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 510831000607 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831000608 Winged helix-turn helix; Region: HTH_29; pfam13551 510831000609 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831000610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831000611 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 510831000612 putative active site [active] 510831000613 Zn binding site [ion binding]; other site 510831000614 YGGT family; Region: YGGT; pfam02325 510831000615 YGGT family; Region: YGGT; pfam02325 510831000616 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 510831000617 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 510831000618 Walker A/P-loop; other site 510831000619 ATP binding site [chemical binding]; other site 510831000620 Q-loop/lid; other site 510831000621 ABC transporter signature motif; other site 510831000622 Walker B; other site 510831000623 D-loop; other site 510831000624 H-loop/switch region; other site 510831000625 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 510831000626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 510831000627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 510831000628 Coenzyme A binding pocket [chemical binding]; other site 510831000629 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 510831000630 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 510831000631 ATP-grasp domain; Region: ATP-grasp_4; cl17255 510831000632 potential frameshift: common BLAST hit: gi|134302713|ref|YP_001122681.1| putative ComEC/Rec2-like protein 510831000633 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 510831000634 Competence protein; Region: Competence; pfam03772 510831000635 Competence protein; Region: Competence; pfam03772 510831000636 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 510831000637 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 510831000638 putative acyl-acceptor binding pocket; other site 510831000639 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 510831000640 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 510831000641 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 510831000642 RNA binding site [nucleotide binding]; other site 510831000643 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 510831000644 RNA binding site [nucleotide binding]; other site 510831000645 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 510831000646 RNA binding site [nucleotide binding]; other site 510831000647 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 510831000648 RNA binding site [nucleotide binding]; other site 510831000649 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 510831000650 RNA binding site [nucleotide binding]; other site 510831000651 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 510831000652 RNA binding site [nucleotide binding]; other site 510831000653 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 510831000654 nucleoside/Zn binding site; other site 510831000655 dimer interface [polypeptide binding]; other site 510831000656 catalytic motif [active] 510831000657 D-alanyl-alanine synthetase A; Provisional; Region: PRK14569 510831000658 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 510831000659 ATP-grasp domain; Region: ATP-grasp_4; cl17255 510831000660 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 510831000661 Cell division protein FtsQ; Region: FtsQ; pfam03799 510831000662 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 510831000663 Cell division protein FtsA; Region: FtsA; smart00842 510831000664 Cell division protein FtsA; Region: FtsA; pfam14450 510831000665 cell division protein FtsZ; Validated; Region: PRK09330 510831000666 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 510831000667 nucleotide binding site [chemical binding]; other site 510831000668 SulA interaction site; other site 510831000669 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 510831000670 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 510831000671 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 510831000672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 510831000673 Walker A motif; other site 510831000674 ATP binding site [chemical binding]; other site 510831000675 Walker B motif; other site 510831000676 DNA polymerase III subunit delta'; Validated; Region: PRK08485 510831000677 arginine finger; other site 510831000678 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 510831000679 This domain is found in peptide chain release factors; Region: PCRF; smart00937 510831000680 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 510831000681 RF-1 domain; Region: RF-1; pfam00472 510831000682 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 510831000683 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 510831000684 dimer interface [polypeptide binding]; other site 510831000685 putative anticodon binding site; other site 510831000686 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 510831000687 motif 1; other site 510831000688 active site 510831000689 motif 2; other site 510831000690 motif 3; other site 510831000691 hypothetical protein; Provisional; Region: PRK05208 510831000692 CAAX protease self-immunity; Region: Abi; pfam02517 510831000693 Eps15 homology domain; Region: EH; smart00027 510831000694 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 510831000695 Glutaminase; Region: Glutaminase; cl00907 510831000696 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 510831000697 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 510831000698 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 510831000699 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 510831000700 glutamine synthetase; Region: PLN02284 510831000701 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 510831000702 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 510831000703 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 510831000704 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 510831000705 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 510831000706 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 510831000707 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831000708 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831000709 potential frameshift: common BLAST hit: gi|118496790|ref|YP_897840.1| serine permease 510831000710 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 510831000711 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 510831000712 purine monophosphate binding site [chemical binding]; other site 510831000713 dimer interface [polypeptide binding]; other site 510831000714 putative catalytic residues [active] 510831000715 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 510831000716 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 510831000717 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 510831000718 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 510831000719 GDP-binding site [chemical binding]; other site 510831000720 ACT binding site; other site 510831000721 IMP binding site; other site 510831000722 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 510831000723 active site 510831000724 potential frameshift: common BLAST hit: gi|134302689|ref|YP_001122657.1| Dienelactone hydrolase family protein 510831000725 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 510831000726 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 510831000727 dimer interface [polypeptide binding]; other site 510831000728 putative PBP binding regions; other site 510831000729 ABC-ATPase subunit interface; other site 510831000730 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 510831000731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 510831000732 Walker A/P-loop; other site 510831000733 ATP binding site [chemical binding]; other site 510831000734 Q-loop/lid; other site 510831000735 ABC transporter signature motif; other site 510831000736 Walker B; other site 510831000737 D-loop; other site 510831000738 H-loop/switch region; other site 510831000739 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 510831000740 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 510831000741 intersubunit interface [polypeptide binding]; other site 510831000742 potential frameshift: common BLAST hit: gi|118496798|ref|YP_897848.1| major facilitator superfamily (MFS) transport protein 510831000743 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 510831000744 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 510831000745 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 510831000746 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 510831000747 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 510831000748 primosome assembly protein PriA; Validated; Region: PRK05580 510831000749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 510831000750 ATP binding site [chemical binding]; other site 510831000751 putative Mg++ binding site [ion binding]; other site 510831000752 helicase superfamily c-terminal domain; Region: HELICc; smart00490 510831000753 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831000754 Winged helix-turn helix; Region: HTH_29; pfam13551 510831000755 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831000756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831000757 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 510831000758 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 510831000759 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 510831000760 Phosphoesterase family; Region: Phosphoesterase; pfam04185 510831000761 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 510831000762 LamB/YcsF family protein; Provisional; Region: PRK05406 510831000763 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 510831000764 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 510831000765 metabolite-proton symporter; Region: 2A0106; TIGR00883 510831000766 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831000767 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831000768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831000769 Winged helix-turn helix; Region: HTH_29; pfam13551 510831000770 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 510831000771 catalytic site [active] 510831000772 putative active site [active] 510831000773 putative substrate binding site [chemical binding]; other site 510831000774 dimer interface [polypeptide binding]; other site 510831000775 elongation factor P; Validated; Region: PRK00529 510831000776 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 510831000777 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 510831000778 RNA binding site [nucleotide binding]; other site 510831000779 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 510831000780 RNA binding site [nucleotide binding]; other site 510831000781 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 510831000782 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 510831000783 putative acyl-acceptor binding pocket; other site 510831000784 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 510831000785 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 510831000786 putative acyl-acceptor binding pocket; other site 510831000787 membrane protein insertase; Provisional; Region: PRK01318 510831000788 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 510831000789 hypothetical protein; Provisional; Region: PRK14375 510831000790 Ribonuclease P; Region: Ribonuclease_P; pfam00825 510831000791 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 510831000792 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 510831000793 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 510831000794 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 510831000795 shikimate binding site; other site 510831000796 NAD(P) binding site [chemical binding]; other site 510831000797 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 510831000798 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 510831000799 NAD(P) binding site [chemical binding]; other site 510831000800 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 510831000801 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 510831000802 Predicted methyltransferases [General function prediction only]; Region: COG0313 510831000803 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 510831000804 putative SAM binding site [chemical binding]; other site 510831000805 putative homodimer interface [polypeptide binding]; other site 510831000806 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 510831000807 Mitochondrial PGP phosphatase; Region: PGP_phosphatase; pfam09419 510831000808 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 510831000809 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 510831000810 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 510831000811 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 510831000812 PLD-like domain; Region: PLDc_2; pfam13091 510831000813 putative homodimer interface [polypeptide binding]; other site 510831000814 putative active site [active] 510831000815 catalytic site [active] 510831000816 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 510831000817 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 510831000818 ATP binding site [chemical binding]; other site 510831000819 putative Mg++ binding site [ion binding]; other site 510831000820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 510831000821 nucleotide binding region [chemical binding]; other site 510831000822 ATP-binding site [chemical binding]; other site 510831000823 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 510831000824 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 510831000825 Ligand Binding Site [chemical binding]; other site 510831000826 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 510831000827 Ligand Binding Site [chemical binding]; other site 510831000828 proline/glycine betaine transporter; Provisional; Region: PRK10642 510831000829 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831000830 Winged helix-turn helix; Region: HTH_29; pfam13551 510831000831 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831000832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831000833 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 510831000834 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 510831000835 G1 box; other site 510831000836 GTP/Mg2+ binding site [chemical binding]; other site 510831000837 Switch I region; other site 510831000838 G2 box; other site 510831000839 G3 box; other site 510831000840 Switch II region; other site 510831000841 G4 box; other site 510831000842 G5 box; other site 510831000843 Nucleoside recognition; Region: Gate; pfam07670 510831000844 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 510831000845 Nucleoside recognition; Region: Gate; pfam07670 510831000846 pyruvate phosphate dikinase; Provisional; Region: PRK09279 510831000847 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 510831000848 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 510831000849 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 510831000850 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 510831000851 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 510831000852 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 510831000853 homodimer interface [polypeptide binding]; other site 510831000854 substrate-cofactor binding pocket; other site 510831000855 catalytic residue [active] 510831000856 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 510831000857 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 510831000858 active site 510831000859 catalytic residues [active] 510831000860 metal binding site [ion binding]; metal-binding site 510831000861 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831000862 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831000863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831000864 Winged helix-turn helix; Region: HTH_29; pfam13551 510831000865 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 510831000866 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 510831000867 RNB domain; Region: RNB; pfam00773 510831000868 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 510831000869 putative hydrolase; Provisional; Region: PRK11460 510831000870 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 510831000871 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 510831000872 domain interfaces; other site 510831000873 active site 510831000874 camphor resistance protein CrcB; Provisional; Region: PRK14226 510831000875 Zinc-finger domain; Region: zf-CHCC; cl01821 510831000876 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 510831000877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 510831000878 dimer interface [polypeptide binding]; other site 510831000879 conserved gate region; other site 510831000880 putative PBP binding loops; other site 510831000881 ABC-ATPase subunit interface; other site 510831000882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 510831000883 dimer interface [polypeptide binding]; other site 510831000884 conserved gate region; other site 510831000885 putative PBP binding loops; other site 510831000886 ABC-ATPase subunit interface; other site 510831000887 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 510831000888 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 510831000889 Walker A/P-loop; other site 510831000890 ATP binding site [chemical binding]; other site 510831000891 Q-loop/lid; other site 510831000892 ABC transporter signature motif; other site 510831000893 Walker B; other site 510831000894 D-loop; other site 510831000895 H-loop/switch region; other site 510831000896 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 510831000897 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 510831000898 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 510831000899 TrkA-N domain; Region: TrkA_N; pfam02254 510831000900 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 510831000901 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 510831000902 trimer interface [polypeptide binding]; other site 510831000903 putative metal binding site [ion binding]; other site 510831000904 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 510831000905 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 510831000906 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 510831000907 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 510831000908 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831000909 Winged helix-turn helix; Region: HTH_29; pfam13551 510831000910 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831000911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831000912 potential frameshift: common BLAST hit: gi|156501568|ref|YP_001427634.1| major facilitator superfamily 510831000913 potential frameshift: common BLAST hit: gi|134302629|ref|YP_001122600.1| cyclohexadienyl dehydratase 510831000914 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 510831000915 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 510831000916 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 510831000917 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 510831000918 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 510831000919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831000920 Major Facilitator Superfamily; Region: MFS_1; pfam07690 510831000921 putative substrate translocation pore; other site 510831000922 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 510831000923 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 510831000924 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 510831000925 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 510831000926 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 510831000927 D-pathway; other site 510831000928 Putative ubiquinol binding site [chemical binding]; other site 510831000929 Low-spin heme (heme b) binding site [chemical binding]; other site 510831000930 Putative water exit pathway; other site 510831000931 Binuclear center (heme o3/CuB) [ion binding]; other site 510831000932 K-pathway; other site 510831000933 Putative proton exit pathway; other site 510831000934 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 510831000935 Subunit I/III interface [polypeptide binding]; other site 510831000936 Subunit III/IV interface [polypeptide binding]; other site 510831000937 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 510831000938 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 510831000939 UbiA prenyltransferase family; Region: UbiA; pfam01040 510831000940 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 510831000941 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 510831000942 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 510831000943 trimer interface [polypeptide binding]; other site 510831000944 active site 510831000945 UDP-GlcNAc binding site [chemical binding]; other site 510831000946 lipid binding site [chemical binding]; lipid-binding site 510831000947 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 510831000948 pyridoxamine kinase; Validated; Region: PRK05756 510831000949 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 510831000950 dimer interface [polypeptide binding]; other site 510831000951 pyridoxal binding site [chemical binding]; other site 510831000952 ATP binding site [chemical binding]; other site 510831000953 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 510831000954 MoxR-like ATPases [General function prediction only]; Region: COG0714 510831000955 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 510831000956 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 510831000957 Protein of unknown function DUF58; Region: DUF58; pfam01882 510831000958 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 510831000959 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 510831000960 metal ion-dependent adhesion site (MIDAS); other site 510831000961 hypothetical protein; Provisional; Region: PRK13685 510831000962 von Willebrand factor type A domain; Region: VWA_2; pfam13519 510831000963 metal ion-dependent adhesion site (MIDAS); other site 510831000964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 510831000965 Tetratricopeptide repeat; Region: TPR_16; pfam13432 510831000966 TPR motif; other site 510831000967 binding surface 510831000968 Oxygen tolerance; Region: BatD; pfam13584 510831000969 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 510831000970 putative substrate binding pocket [chemical binding]; other site 510831000971 AC domain interface; other site 510831000972 catalytic triad [active] 510831000973 AB domain interface; other site 510831000974 interchain disulfide; other site 510831000975 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 510831000976 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 510831000977 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 510831000978 HIGH motif; other site 510831000979 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 510831000980 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 510831000981 active site 510831000982 KMSKS motif; other site 510831000983 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 510831000984 tRNA binding surface [nucleotide binding]; other site 510831000985 anticodon binding site; other site 510831000986 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 510831000987 1-deoxy-D-xylulose-5-phosphate synthase; Region: PLN02225 510831000988 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 510831000989 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 510831000990 phosphate binding site [ion binding]; other site 510831000991 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 510831000992 dimer interface [polypeptide binding]; other site 510831000993 FMN binding site [chemical binding]; other site 510831000994 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 510831000995 nudix motif; other site 510831000996 fumarate hydratase; Reviewed; Region: fumC; PRK00485 510831000997 Class II fumarases; Region: Fumarase_classII; cd01362 510831000998 active site 510831000999 tetramer interface [polypeptide binding]; other site 510831001000 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 510831001001 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 510831001002 HIGH motif; other site 510831001003 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 510831001004 active site 510831001005 KMSKS motif; other site 510831001006 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 510831001007 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831001008 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831001009 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 510831001010 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 510831001011 Amidinotransferase; Region: Amidinotransf; pfam02274 510831001012 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 510831001013 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 510831001014 folate binding site [chemical binding]; other site 510831001015 NADP+ binding site [chemical binding]; other site 510831001016 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 510831001017 rRNA interaction site [nucleotide binding]; other site 510831001018 S8 interaction site; other site 510831001019 putative laminin-1 binding site; other site 510831001020 elongation factor Ts; Provisional; Region: tsf; PRK09377 510831001021 UBA/TS-N domain; Region: UBA; pfam00627 510831001022 Elongation factor TS; Region: EF_TS; pfam00889 510831001023 Elongation factor TS; Region: EF_TS; pfam00889 510831001024 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 510831001025 putative nucleotide binding site [chemical binding]; other site 510831001026 uridine monophosphate binding site [chemical binding]; other site 510831001027 homohexameric interface [polypeptide binding]; other site 510831001028 ribosome recycling factor; Reviewed; Region: frr; PRK00083 510831001029 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 510831001030 hinge region; other site 510831001031 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 510831001032 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 510831001033 catalytic residue [active] 510831001034 putative FPP diphosphate binding site; other site 510831001035 putative FPP binding hydrophobic cleft; other site 510831001036 dimer interface [polypeptide binding]; other site 510831001037 putative IPP diphosphate binding site; other site 510831001038 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 510831001039 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 510831001040 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 510831001041 trimer interface [polypeptide binding]; other site 510831001042 active site 510831001043 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 510831001044 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 510831001045 S17 interaction site [polypeptide binding]; other site 510831001046 S8 interaction site; other site 510831001047 16S rRNA interaction site [nucleotide binding]; other site 510831001048 streptomycin interaction site [chemical binding]; other site 510831001049 23S rRNA interaction site [nucleotide binding]; other site 510831001050 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 510831001051 30S ribosomal protein S7; Validated; Region: PRK05302 510831001052 elongation factor G; Reviewed; Region: PRK00007 510831001053 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 510831001054 G1 box; other site 510831001055 putative GEF interaction site [polypeptide binding]; other site 510831001056 GTP/Mg2+ binding site [chemical binding]; other site 510831001057 Switch I region; other site 510831001058 G2 box; other site 510831001059 G3 box; other site 510831001060 Switch II region; other site 510831001061 G4 box; other site 510831001062 G5 box; other site 510831001063 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 510831001064 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 510831001065 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 510831001066 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 510831001067 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 510831001068 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 510831001069 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 510831001070 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 510831001071 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 510831001072 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 510831001073 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 510831001074 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 510831001075 putative translocon binding site; other site 510831001076 protein-rRNA interface [nucleotide binding]; other site 510831001077 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 510831001078 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 510831001079 G-X-X-G motif; other site 510831001080 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 510831001081 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 510831001082 23S rRNA interface [nucleotide binding]; other site 510831001083 5S rRNA interface [nucleotide binding]; other site 510831001084 putative antibiotic binding site [chemical binding]; other site 510831001085 L25 interface [polypeptide binding]; other site 510831001086 L27 interface [polypeptide binding]; other site 510831001087 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 510831001088 23S rRNA interface [nucleotide binding]; other site 510831001089 putative translocon interaction site; other site 510831001090 signal recognition particle (SRP54) interaction site; other site 510831001091 L23 interface [polypeptide binding]; other site 510831001092 trigger factor interaction site; other site 510831001093 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 510831001094 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 510831001095 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 510831001096 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 510831001097 RNA binding site [nucleotide binding]; other site 510831001098 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 510831001099 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 510831001100 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 510831001101 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 510831001102 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 510831001103 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 510831001104 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 510831001105 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 510831001106 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 510831001107 23S rRNA interface [nucleotide binding]; other site 510831001108 L21e interface [polypeptide binding]; other site 510831001109 5S rRNA interface [nucleotide binding]; other site 510831001110 L27 interface [polypeptide binding]; other site 510831001111 L5 interface [polypeptide binding]; other site 510831001112 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 510831001113 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 510831001114 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 510831001115 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 510831001116 23S rRNA binding site [nucleotide binding]; other site 510831001117 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 510831001118 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 510831001119 SecY translocase; Region: SecY; pfam00344 510831001120 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 510831001121 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 510831001122 30S ribosomal protein S13; Region: bact_S13; TIGR03631 510831001123 30S ribosomal protein S11; Validated; Region: PRK05309 510831001124 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 510831001125 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 510831001126 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 510831001127 RNA binding surface [nucleotide binding]; other site 510831001128 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 510831001129 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 510831001130 alphaNTD homodimer interface [polypeptide binding]; other site 510831001131 alphaNTD - beta interaction site [polypeptide binding]; other site 510831001132 alphaNTD - beta' interaction site [polypeptide binding]; other site 510831001133 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 510831001134 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 510831001135 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831001136 Winged helix-turn helix; Region: HTH_29; pfam13551 510831001137 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831001138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831001139 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831001140 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831001141 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 510831001142 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831001143 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831001144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831001145 Winged helix-turn helix; Region: HTH_29; pfam13551 510831001146 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 510831001147 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 510831001148 CTP synthetase; Validated; Region: pyrG; PRK05380 510831001149 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 510831001150 Catalytic site [active] 510831001151 active site 510831001152 UTP binding site [chemical binding]; other site 510831001153 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 510831001154 active site 510831001155 putative oxyanion hole; other site 510831001156 catalytic triad [active] 510831001157 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 510831001158 active site 510831001159 multimer interface [polypeptide binding]; other site 510831001160 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 510831001161 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 510831001162 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 510831001163 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 510831001164 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 510831001165 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 510831001166 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 510831001167 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 510831001168 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 510831001169 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 510831001170 ferredoxin-NADP reductase; Provisional; Region: PRK10926 510831001171 FAD binding pocket [chemical binding]; other site 510831001172 FAD binding motif [chemical binding]; other site 510831001173 phosphate binding motif [ion binding]; other site 510831001174 beta-alpha-beta structure motif; other site 510831001175 NAD binding pocket [chemical binding]; other site 510831001176 SnoaL-like domain; Region: SnoaL_2; pfam12680 510831001177 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831001178 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831001179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831001180 Winged helix-turn helix; Region: HTH_29; pfam13551 510831001181 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 510831001182 short chain dehydrogenase; Provisional; Region: PRK05993 510831001183 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 510831001184 NADP binding site [chemical binding]; other site 510831001185 active site 510831001186 steroid binding site; other site 510831001187 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 510831001188 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831001189 Winged helix-turn helix; Region: HTH_29; pfam13551 510831001190 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831001191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831001192 heat shock protein 90; Provisional; Region: PRK05218 510831001193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 510831001194 ATP binding site [chemical binding]; other site 510831001195 Mg2+ binding site [ion binding]; other site 510831001196 G-X-G motif; other site 510831001197 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831001198 Winged helix-turn helix; Region: HTH_29; pfam13551 510831001199 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831001200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831001201 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 510831001202 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831001203 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831001204 glutamate dehydrogenase; Provisional; Region: PRK09414 510831001205 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 510831001206 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 510831001207 NAD(P) binding site [chemical binding]; other site 510831001208 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 510831001209 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831001210 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831001211 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 510831001212 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 510831001213 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 510831001214 active site 510831001215 (T/H)XGH motif; other site 510831001216 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 510831001217 nudix motif; other site 510831001218 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 510831001219 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 510831001220 Substrate binding site; other site 510831001221 Mg++ binding site; other site 510831001222 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 510831001223 active site 510831001224 substrate binding site [chemical binding]; other site 510831001225 CoA binding site [chemical binding]; other site 510831001226 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 510831001227 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 510831001228 glutaminase active site [active] 510831001229 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 510831001230 dimer interface [polypeptide binding]; other site 510831001231 active site 510831001232 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 510831001233 dimer interface [polypeptide binding]; other site 510831001234 active site 510831001235 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 510831001236 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 510831001237 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 510831001238 DNA-binding site [nucleotide binding]; DNA binding site 510831001239 RNA-binding motif; other site 510831001240 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 510831001241 metal binding site [ion binding]; metal-binding site 510831001242 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 510831001243 active site 510831001244 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 510831001245 PLD-like domain; Region: PLDc_2; pfam13091 510831001246 putative homodimer interface [polypeptide binding]; other site 510831001247 putative active site [active] 510831001248 catalytic site [active] 510831001249 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 510831001250 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 510831001251 CAP-like domain; other site 510831001252 active site 510831001253 primary dimer interface [polypeptide binding]; other site 510831001254 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 510831001255 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 510831001256 BNR repeat-like domain; Region: BNR_2; pfam13088 510831001257 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 510831001258 Asp-box motif; other site 510831001259 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 510831001260 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 510831001261 N-acetyl-D-glucosamine binding site [chemical binding]; other site 510831001262 catalytic residue [active] 510831001263 Predicted membrane protein [Function unknown]; Region: COG4325 510831001264 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 510831001265 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 510831001266 putative active site [active] 510831001267 putative PHP Thumb interface [polypeptide binding]; other site 510831001268 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 510831001269 generic binding surface II; other site 510831001270 generic binding surface I; other site 510831001271 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 510831001272 active site 510831001273 catalytic residues [active] 510831001274 metal binding site [ion binding]; metal-binding site 510831001275 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 510831001276 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 510831001277 FtsX-like permease family; Region: FtsX; pfam02687 510831001278 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 510831001279 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 510831001280 Walker A/P-loop; other site 510831001281 ATP binding site [chemical binding]; other site 510831001282 Q-loop/lid; other site 510831001283 ABC transporter signature motif; other site 510831001284 Walker B; other site 510831001285 D-loop; other site 510831001286 H-loop/switch region; other site 510831001287 lysine decarboxylase LdcC; Provisional; Region: PRK15399 510831001288 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 510831001289 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 510831001290 homodimer interface [polypeptide binding]; other site 510831001291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 510831001292 catalytic residue [active] 510831001293 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 510831001294 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 510831001295 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 510831001296 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 510831001297 lipoyl attachment site [posttranslational modification]; other site 510831001298 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 510831001299 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 510831001300 tetramer interface [polypeptide binding]; other site 510831001301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 510831001302 catalytic residue [active] 510831001303 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 510831001304 tetramer interface [polypeptide binding]; other site 510831001305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 510831001306 catalytic residue [active] 510831001307 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 510831001308 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 510831001309 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 510831001310 shikimate binding site; other site 510831001311 NAD(P) binding site [chemical binding]; other site 510831001312 pullulanase, type I; Region: pulA_typeI; TIGR02104 510831001313 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 510831001314 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 510831001315 Ca binding site [ion binding]; other site 510831001316 active site 510831001317 catalytic site [active] 510831001318 glycogen branching enzyme; Provisional; Region: PRK12313 510831001319 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 510831001320 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 510831001321 active site 510831001322 catalytic site [active] 510831001323 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 510831001324 phosphoglucomutase; Region: PLN02307 510831001325 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 510831001326 substrate binding site [chemical binding]; other site 510831001327 dimer interface [polypeptide binding]; other site 510831001328 active site 510831001329 metal binding site [ion binding]; metal-binding site 510831001330 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 510831001331 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 510831001332 ligand binding site; other site 510831001333 oligomer interface; other site 510831001334 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 510831001335 dimer interface [polypeptide binding]; other site 510831001336 N-terminal domain interface [polypeptide binding]; other site 510831001337 sulfate 1 binding site; other site 510831001338 glycogen synthase; Provisional; Region: glgA; PRK00654 510831001339 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 510831001340 ADP-binding pocket [chemical binding]; other site 510831001341 homodimer interface [polypeptide binding]; other site 510831001342 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 510831001343 homodimer interface [polypeptide binding]; other site 510831001344 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 510831001345 active site pocket [active] 510831001346 4-alpha-glucanotransferase; Provisional; Region: PRK14508 510831001347 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 510831001348 dimer interface [polypeptide binding]; other site 510831001349 motif 1; other site 510831001350 active site 510831001351 motif 2; other site 510831001352 motif 3; other site 510831001353 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 510831001354 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 510831001355 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 510831001356 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 510831001357 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 510831001358 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 510831001359 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 510831001360 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 510831001361 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 510831001362 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 510831001363 potential frameshift: common BLAST hit: gi|134302492|ref|YP_001122462.1| bifunctional aspartokinase/homoserine dehydrogenase 510831001364 potential frameshift: common BLAST hit: gi|134302491|ref|YP_001122461.1| homoserine kinase 510831001365 threonine synthase; Validated; Region: PRK09225 510831001366 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 510831001367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 510831001368 catalytic residue [active] 510831001369 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 510831001370 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 510831001371 spermidine synthase; Provisional; Region: PRK00811 510831001372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 510831001373 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 510831001374 dimer interface [polypeptide binding]; other site 510831001375 active site 510831001376 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 510831001377 catalytic residues [active] 510831001378 substrate binding site [chemical binding]; other site 510831001379 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 510831001380 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 510831001381 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 510831001382 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 510831001383 putative active site; other site 510831001384 catalytic triad [active] 510831001385 putative dimer interface [polypeptide binding]; other site 510831001386 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 510831001387 putative active site [active] 510831001388 putative metal binding site [ion binding]; other site 510831001389 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 510831001390 active site 510831001391 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 510831001392 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 510831001393 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 510831001394 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 510831001395 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 510831001396 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 510831001397 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831001398 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831001399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831001400 Winged helix-turn helix; Region: HTH_29; pfam13551 510831001401 potential frameshift: common BLAST hit: gi|156503080|ref|YP_001429145.1| NADH dehydrogenase subunit 510831001402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831001403 putative substrate translocation pore; other site 510831001404 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 510831001405 Predicted membrane protein [Function unknown]; Region: COG4129 510831001406 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 510831001407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831001408 Major Facilitator Superfamily; Region: MFS_1; pfam07690 510831001409 putative substrate translocation pore; other site 510831001410 potential frameshift: common BLAST hit: gi|134302476|ref|YP_001122446.1| ABC transporter, ATP-binding protein 510831001411 potential frameshift: common BLAST hit: gi|134302476|ref|YP_001122446.1| ABC transporter, ATP-binding protein 510831001412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831001413 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 510831001414 putative substrate translocation pore; other site 510831001415 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 510831001416 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 510831001417 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 510831001418 active site 510831001419 HIGH motif; other site 510831001420 nucleotide binding site [chemical binding]; other site 510831001421 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 510831001422 KMSKS motif; other site 510831001423 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 510831001424 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 510831001425 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 510831001426 active site 510831001427 metal-binding site [ion binding] 510831001428 nucleotide-binding site [chemical binding]; other site 510831001429 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 510831001430 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 510831001431 Mg++ binding site [ion binding]; other site 510831001432 putative catalytic motif [active] 510831001433 putative substrate binding site [chemical binding]; other site 510831001434 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 510831001435 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 510831001436 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 510831001437 cell division protein FtsW; Region: ftsW; TIGR02614 510831001438 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 510831001439 putative active site [active] 510831001440 YdjC motif; other site 510831001441 Mg binding site [ion binding]; other site 510831001442 putative homodimer interface [polypeptide binding]; other site 510831001443 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 510831001444 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 510831001445 Ligand binding site; other site 510831001446 Putative Catalytic site; other site 510831001447 DXD motif; other site 510831001448 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 510831001449 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 510831001450 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 510831001451 oxidative damage protection protein; Provisional; Region: PRK05408 510831001452 DsrC like protein; Region: DsrC; pfam04358 510831001453 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 510831001454 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 510831001455 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 510831001456 dimer interface [polypeptide binding]; other site 510831001457 N-terminal domain interface [polypeptide binding]; other site 510831001458 putative inner membrane peptidase; Provisional; Region: PRK11778 510831001459 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 510831001460 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 510831001461 tandem repeat interface [polypeptide binding]; other site 510831001462 oligomer interface [polypeptide binding]; other site 510831001463 active site residues [active] 510831001464 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 510831001465 DNA polymerase III subunit delta'; Validated; Region: PRK07993 510831001466 DNA polymerase III subunit delta'; Validated; Region: PRK08485 510831001467 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 510831001468 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 510831001469 dimer interface [polypeptide binding]; other site 510831001470 active site 510831001471 Schiff base residues; other site 510831001472 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 510831001473 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 510831001474 active site 510831001475 homotetramer interface [polypeptide binding]; other site 510831001476 homodimer interface [polypeptide binding]; other site 510831001477 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 510831001478 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 510831001479 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 510831001480 active site 510831001481 HIGH motif; other site 510831001482 nucleotide binding site [chemical binding]; other site 510831001483 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 510831001484 KMSK motif region; other site 510831001485 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 510831001486 tRNA binding surface [nucleotide binding]; other site 510831001487 anticodon binding site; other site 510831001488 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 510831001489 Organic solvent tolerance protein; Region: OstA_C; pfam04453 510831001490 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 510831001491 SurA N-terminal domain; Region: SurA_N; pfam09312 510831001492 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 510831001493 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 510831001494 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 510831001495 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 510831001496 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 510831001497 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 510831001498 active site 510831001499 metal binding site [ion binding]; metal-binding site 510831001500 Dehydroquinase class II; Region: DHquinase_II; pfam01220 510831001501 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 510831001502 trimer interface [polypeptide binding]; other site 510831001503 active site 510831001504 dimer interface [polypeptide binding]; other site 510831001505 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 510831001506 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 510831001507 carboxyltransferase (CT) interaction site; other site 510831001508 biotinylation site [posttranslational modification]; other site 510831001509 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 510831001510 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 510831001511 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 510831001512 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 510831001513 Helix-turn-helix domain; Region: HTH_25; pfam13413 510831001514 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 510831001515 Mechanosensitive ion channel; Region: MS_channel; pfam00924 510831001516 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 510831001517 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 510831001518 motif 1; other site 510831001519 dimer interface [polypeptide binding]; other site 510831001520 active site 510831001521 motif 2; other site 510831001522 motif 3; other site 510831001523 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 510831001524 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 510831001525 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 510831001526 DHH family; Region: DHH; pfam01368 510831001527 DHHA1 domain; Region: DHHA1; pfam02272 510831001528 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 510831001529 Domain of unknown function DUF20; Region: UPF0118; pfam01594 510831001530 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 510831001531 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 510831001532 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 510831001533 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 510831001534 Predicted GTPases [General function prediction only]; Region: COG1162 510831001535 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 510831001536 RNA binding site [nucleotide binding]; other site 510831001537 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 510831001538 GTPase/Zn-binding domain interface [polypeptide binding]; other site 510831001539 GTP/Mg2+ binding site [chemical binding]; other site 510831001540 G4 box; other site 510831001541 G5 box; other site 510831001542 G1 box; other site 510831001543 Switch I region; other site 510831001544 G2 box; other site 510831001545 G3 box; other site 510831001546 Switch II region; other site 510831001547 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 510831001548 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 510831001549 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 510831001550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 510831001551 ATP binding site [chemical binding]; other site 510831001552 Mg2+ binding site [ion binding]; other site 510831001553 G-X-G motif; other site 510831001554 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 510831001555 ATP binding site [chemical binding]; other site 510831001556 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 510831001557 potential frameshift: common BLAST hit: gi|118497177|ref|YP_898227.1| major facilitator superfamily (MFS) transport protein 510831001558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831001559 Major Facilitator Superfamily; Region: MFS_1; pfam07690 510831001560 putative substrate translocation pore; other site 510831001561 thioredoxin reductase; Provisional; Region: PRK10262 510831001562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 510831001563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 510831001564 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 510831001565 PLD-like domain; Region: PLDc_2; pfam13091 510831001566 putative active site [active] 510831001567 catalytic site [active] 510831001568 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 510831001569 PLD-like domain; Region: PLDc_2; pfam13091 510831001570 putative active site [active] 510831001571 putative catalytic site [active] 510831001572 phosphoglycolate phosphatase; Provisional; Region: PRK13222 510831001573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 510831001574 motif II; other site 510831001575 Transcriptional regulator [Transcription]; Region: LysR; COG0583 510831001576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 510831001577 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 510831001578 putative effector binding pocket; other site 510831001579 dimerization interface [polypeptide binding]; other site 510831001580 potential frameshift: common BLAST hit: gi|118497183|ref|YP_898233.1| conserved inner membrane protein of unknown function 510831001581 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 510831001582 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 510831001583 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 510831001584 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 510831001585 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 510831001586 dimer interface [polypeptide binding]; other site 510831001587 active site 510831001588 catalytic nucleophile [active] 510831001589 potential frameshift: common BLAST hit: gi|167626470|ref|YP_001676970.1| Alkaline phosphatase [Francisella philomiragia subsp. philomiragia 510831001590 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 510831001591 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 510831001592 CoA binding domain; Region: CoA_binding; smart00881 510831001593 CoA-ligase; Region: Ligase_CoA; pfam00549 510831001594 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 510831001595 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 510831001596 CoA-ligase; Region: Ligase_CoA; pfam00549 510831001597 TIGR03546 family protein; Region: TIGR03546 510831001598 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 510831001599 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 510831001600 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 510831001601 FMN binding site [chemical binding]; other site 510831001602 active site 510831001603 catalytic residues [active] 510831001604 substrate binding site [chemical binding]; other site 510831001605 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 510831001606 putative active site pocket [active] 510831001607 dimerization interface [polypeptide binding]; other site 510831001608 putative catalytic residue [active] 510831001609 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 510831001610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 510831001611 ATP binding site [chemical binding]; other site 510831001612 Mg2+ binding site [ion binding]; other site 510831001613 G-X-G motif; other site 510831001614 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 510831001615 anchoring element; other site 510831001616 dimer interface [polypeptide binding]; other site 510831001617 ATP binding site [chemical binding]; other site 510831001618 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 510831001619 active site 510831001620 putative metal-binding site [ion binding]; other site 510831001621 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 510831001622 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 510831001623 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 510831001624 active site 510831001625 multimer interface [polypeptide binding]; other site 510831001626 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 510831001627 predicted active site [active] 510831001628 catalytic triad [active] 510831001629 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831001630 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831001631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831001632 Winged helix-turn helix; Region: HTH_29; pfam13551 510831001633 potential frameshift: common BLAST hit: gi|134302004|ref|YP_001121973.1| L-lactate dehydrogenase 510831001634 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 510831001635 potential frameshift: common BLAST hit: gi|115314767|ref|YP_763490.1| probable FAD/FMN-dehydrogenase 510831001636 potential frameshift: common BLAST hit: gi|118497582|ref|YP_898632.1| 4Fe-4S ferredoxin, FAD dependent 510831001637 potential frameshift: common BLAST hit: gi|115314768|ref|YP_763491.1| probable iron (Fe2+)-dependent alcohol dehydrogenase 510831001638 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 510831001639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 510831001640 S-adenosylmethionine binding site [chemical binding]; other site 510831001641 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 510831001642 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 510831001643 FMN binding site [chemical binding]; other site 510831001644 active site 510831001645 catalytic residues [active] 510831001646 substrate binding site [chemical binding]; other site 510831001647 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 510831001648 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 510831001649 Methyltransferase domain; Region: Methyltransf_26; pfam13659 510831001650 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 510831001651 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 510831001652 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 510831001653 putative active site [active] 510831001654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 510831001655 AAA domain; Region: AAA_21; pfam13304 510831001656 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 510831001657 Walker A/P-loop; other site 510831001658 Walker A/P-loop; other site 510831001659 ATP binding site [chemical binding]; other site 510831001660 ATP binding site [chemical binding]; other site 510831001661 Y-family of DNA polymerases; Region: PolY; cl12025 510831001662 DNA binding site [nucleotide binding] 510831001663 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 510831001664 active site 510831001665 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 510831001666 DJ-1 family protein; Region: not_thiJ; TIGR01383 510831001667 conserved cys residue [active] 510831001668 potential frameshift: common BLAST hit: gi|118497576|ref|YP_898626.1| ABC transporter, ATP-binding protein 510831001669 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 510831001670 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 510831001671 GSH binding site [chemical binding]; other site 510831001672 catalytic residues [active] 510831001673 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 510831001674 dimer interface [polypeptide binding]; other site 510831001675 putative radical transfer pathway; other site 510831001676 diiron center [ion binding]; other site 510831001677 tyrosyl radical; other site 510831001678 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 510831001679 GSH binding site [chemical binding]; other site 510831001680 catalytic residues [active] 510831001681 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 510831001682 Class I ribonucleotide reductase; Region: RNR_I; cd01679 510831001683 active site 510831001684 dimer interface [polypeptide binding]; other site 510831001685 catalytic residues [active] 510831001686 effector binding site; other site 510831001687 R2 peptide binding site; other site 510831001688 malate dehydrogenase; Reviewed; Region: PRK06223 510831001689 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 510831001690 NAD(P) binding site [chemical binding]; other site 510831001691 dimer interface [polypeptide binding]; other site 510831001692 tetramer (dimer of dimers) interface [polypeptide binding]; other site 510831001693 substrate binding site [chemical binding]; other site 510831001694 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 510831001695 diiron binding motif [ion binding]; other site 510831001696 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 510831001697 N-acetyl-D-glucosamine binding site [chemical binding]; other site 510831001698 catalytic residue [active] 510831001699 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 510831001700 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 510831001701 putative ATP binding site [chemical binding]; other site 510831001702 putative substrate interface [chemical binding]; other site 510831001703 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 510831001704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 510831001705 motif II; other site 510831001706 potential frameshift: common BLAST hit: gi|156502417|ref|YP_001428482.1| AhpC/Tsa family protein 510831001707 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 510831001708 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 510831001709 PhnA protein; Region: PhnA; pfam03831 510831001710 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 510831001711 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 510831001712 active site 510831001713 catalytic site [active] 510831001714 substrate binding site [chemical binding]; other site 510831001715 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 510831001716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 510831001717 potential frameshift: common BLAST hit: gi|118497556|ref|YP_898606.1| dehydrogenase 510831001718 potential frameshift: common BLAST hit: gi|118497556|ref|YP_898606.1| dehydrogenase 510831001719 aldehyde dehydrogenase family 7 member; Region: PLN02315 510831001720 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 510831001721 tetrameric interface [polypeptide binding]; other site 510831001722 NAD binding site [chemical binding]; other site 510831001723 catalytic residues [active] 510831001724 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 510831001725 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 510831001726 putative homodimer interface [polypeptide binding]; other site 510831001727 putative homotetramer interface [polypeptide binding]; other site 510831001728 putative allosteric switch controlling residues; other site 510831001729 putative metal binding site [ion binding]; other site 510831001730 putative homodimer-homodimer interface [polypeptide binding]; other site 510831001731 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 510831001732 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 510831001733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 510831001734 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 510831001735 dimerization interface [polypeptide binding]; other site 510831001736 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 510831001737 catalytic triad [active] 510831001738 dimer interface [polypeptide binding]; other site 510831001739 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 510831001740 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 510831001741 putative NAD(P) binding site [chemical binding]; other site 510831001742 homodimer interface [polypeptide binding]; other site 510831001743 cytidylate kinase; Provisional; Region: cmk; PRK00023 510831001744 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 510831001745 CMP-binding site; other site 510831001746 The sites determining sugar specificity; other site 510831001747 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 510831001748 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 510831001749 catalytic residue [active] 510831001750 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831001751 Winged helix-turn helix; Region: HTH_29; pfam13551 510831001752 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831001753 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831001754 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 510831001755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 510831001756 Walker A/P-loop; other site 510831001757 ATP binding site [chemical binding]; other site 510831001758 Q-loop/lid; other site 510831001759 ABC transporter signature motif; other site 510831001760 Walker B; other site 510831001761 D-loop; other site 510831001762 H-loop/switch region; other site 510831001763 TOBE domain; Region: TOBE_2; pfam08402 510831001764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 510831001765 dimer interface [polypeptide binding]; other site 510831001766 conserved gate region; other site 510831001767 putative PBP binding loops; other site 510831001768 ABC-ATPase subunit interface; other site 510831001769 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 510831001770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 510831001771 dimer interface [polypeptide binding]; other site 510831001772 conserved gate region; other site 510831001773 putative PBP binding loops; other site 510831001774 ABC-ATPase subunit interface; other site 510831001775 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 510831001776 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831001777 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831001778 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 510831001779 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 510831001780 motif II; other site 510831001781 hypothetical protein; Provisional; Region: PRK14013 510831001782 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 510831001783 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 510831001784 putative C-terminal domain interface [polypeptide binding]; other site 510831001785 putative GSH binding site [chemical binding]; other site 510831001786 putative dimer interface [polypeptide binding]; other site 510831001787 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 510831001788 dimer interface [polypeptide binding]; other site 510831001789 substrate binding pocket (H-site) [chemical binding]; other site 510831001790 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 510831001791 putative N-terminal domain interface [polypeptide binding]; other site 510831001792 POT family; Region: PTR2; cl17359 510831001793 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 510831001794 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 510831001795 active site 510831001796 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 510831001797 dimer interface [polypeptide binding]; other site 510831001798 substrate binding site [chemical binding]; other site 510831001799 catalytic residues [active] 510831001800 potential frameshift: common BLAST hit: gi|118497342|ref|YP_898392.1| amino acid-polyamine-organocation (APC) superfamily protein 510831001801 potential frameshift: common BLAST hit: gi|118497342|ref|YP_898392.1| amino acid-polyamine-organocation (APC) superfamily protein 510831001802 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 510831001803 Prephenate dehydratase; Region: PDT; pfam00800 510831001804 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 510831001805 putative L-Phe binding site [chemical binding]; other site 510831001806 Protein of unknown function DUF45; Region: DUF45; pfam01863 510831001807 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 510831001808 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 510831001809 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 510831001810 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 510831001811 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 510831001812 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 510831001813 catalytic residue [active] 510831001814 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 510831001815 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 510831001816 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 510831001817 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 510831001818 active site 510831001819 (T/H)XGH motif; other site 510831001820 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 510831001821 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 510831001822 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 510831001823 ligand binding site [chemical binding]; other site 510831001824 CRISPR/Cas system-associated protein Cas9; Region: Csx12; cd09704 510831001825 CRISPR-associated protein Cas9/Csx12, subtype II-B/NMENI; Region: cas_csx12; TIGR03031 510831001826 potential frameshift: common BLAST hit: gi|167628642|ref|YP_001679141.1| crispr-associated protein cas1 [Heliobacterium modesticaldum Ice1] 510831001827 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 510831001828 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 510831001829 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831001830 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831001831 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 510831001832 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 510831001833 hinge; other site 510831001834 active site 510831001835 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 510831001836 RNA/DNA hybrid binding site [nucleotide binding]; other site 510831001837 active site 510831001838 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 510831001839 active site 510831001840 homodimer interface [polypeptide binding]; other site 510831001841 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 510831001842 active site clefts [active] 510831001843 zinc binding site [ion binding]; other site 510831001844 dimer interface [polypeptide binding]; other site 510831001845 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 510831001846 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 510831001847 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 510831001848 catalytic residue [active] 510831001849 Rubredoxin [Energy production and conversion]; Region: COG1773 510831001850 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 510831001851 iron binding site [ion binding]; other site 510831001852 Uncharacterized conserved protein [Function unknown]; Region: COG0397 510831001853 hypothetical protein; Validated; Region: PRK00029 510831001854 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 510831001855 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 510831001856 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 510831001857 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 510831001858 dimer interface [polypeptide binding]; other site 510831001859 active site 510831001860 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 510831001861 dimer interface [polypeptide binding]; other site 510831001862 active site 510831001863 potential frameshift: common BLAST hit: gi|134302089|ref|YP_001122058.1| sugar transporter, MFS family 510831001864 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 510831001865 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 510831001866 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 510831001867 potassium/proton antiporter; Reviewed; Region: PRK05326 510831001868 Uncharacterized conserved protein [Function unknown]; Region: COG0327 510831001869 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 510831001870 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 510831001871 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 510831001872 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 510831001873 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 510831001874 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 510831001875 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 510831001876 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 510831001877 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 510831001878 active site 510831001879 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 510831001880 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 510831001881 active site 510831001882 substrate binding site [chemical binding]; other site 510831001883 Mg2+ binding site [ion binding]; other site 510831001884 beta-lactamase TEM; Provisional; Region: PRK15442 510831001885 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 510831001886 VirK protein; Region: VirK; pfam06903 510831001887 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 510831001888 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 510831001889 putative active site [active] 510831001890 catalytic triad [active] 510831001891 putative dimer interface [polypeptide binding]; other site 510831001892 FOG: CBS domain [General function prediction only]; Region: COG0517 510831001893 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 510831001894 Transporter associated domain; Region: CorC_HlyC; smart01091 510831001895 metal-binding heat shock protein; Provisional; Region: PRK00016 510831001896 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 510831001897 PhoH-like protein; Region: PhoH; pfam02562 510831001898 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 510831001899 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 510831001900 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 510831001901 FeS/SAM binding site; other site 510831001902 TRAM domain; Region: TRAM; pfam01938 510831001903 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 510831001904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 510831001905 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 510831001906 thymidine kinase; Provisional; Region: PRK04296 510831001907 trigger factor; Provisional; Region: tig; PRK01490 510831001908 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 510831001909 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 510831001910 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 510831001911 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 510831001912 oligomer interface [polypeptide binding]; other site 510831001913 active site residues [active] 510831001914 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 510831001915 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 510831001916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 510831001917 Walker A motif; other site 510831001918 ATP binding site [chemical binding]; other site 510831001919 Walker B motif; other site 510831001920 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 510831001921 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 510831001922 Found in ATP-dependent protease La (LON); Region: LON; smart00464 510831001923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 510831001924 Walker A motif; other site 510831001925 ATP binding site [chemical binding]; other site 510831001926 Walker B motif; other site 510831001927 arginine finger; other site 510831001928 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 510831001929 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 510831001930 IHF dimer interface [polypeptide binding]; other site 510831001931 IHF - DNA interface [nucleotide binding]; other site 510831001932 SurA N-terminal domain; Region: SurA_N_3; cl07813 510831001933 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 510831001934 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 510831001935 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 510831001936 bacterial Hfq-like; Region: Hfq; cd01716 510831001937 hexamer interface [polypeptide binding]; other site 510831001938 Sm1 motif; other site 510831001939 RNA binding site [nucleotide binding]; other site 510831001940 Sm2 motif; other site 510831001941 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 510831001942 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 510831001943 HflX GTPase family; Region: HflX; cd01878 510831001944 G1 box; other site 510831001945 GTP/Mg2+ binding site [chemical binding]; other site 510831001946 Switch I region; other site 510831001947 G2 box; other site 510831001948 G3 box; other site 510831001949 Switch II region; other site 510831001950 G4 box; other site 510831001951 G5 box; other site 510831001952 hypothetical protein; Provisional; Region: PRK07588 510831001953 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 510831001954 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 510831001955 HflK protein; Region: hflK; TIGR01933 510831001956 FtsH protease regulator HflC; Provisional; Region: PRK11029 510831001957 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 510831001958 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 510831001959 Low molecular weight phosphatase family; Region: LMWPc; cd00115 510831001960 active site 510831001961 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 510831001962 G1 box; other site 510831001963 GTP/Mg2+ binding site [chemical binding]; other site 510831001964 Switch I region; other site 510831001965 G2 box; other site 510831001966 G3 box; other site 510831001967 Switch II region; other site 510831001968 G4 box; other site 510831001969 G5 box; other site 510831001970 potential frameshift: common BLAST hit: gi|134302056|ref|YP_001122025.1| putative threonine synthase 510831001971 potential frameshift: common BLAST hit: gi|134302056|ref|YP_001122025.1| putative threonine synthase 510831001972 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 510831001973 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 510831001974 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 510831001975 potential frameshift: common BLAST hit: gi|118497633|ref|YP_898683.1| acetolactate synthase large subunit 510831001976 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 510831001977 putative valine binding site [chemical binding]; other site 510831001978 dimer interface [polypeptide binding]; other site 510831001979 potential frameshift: common BLAST hit: gi|156502333|ref|YP_001428398.1| ketol-acid reductoisomerase 510831001980 potential frameshift: common BLAST hit: gi|134302052|ref|YP_001122021.1| ketol-acid reductoisomerase 510831001981 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 510831001982 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 510831001983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 510831001984 ATP binding site [chemical binding]; other site 510831001985 putative Mg++ binding site [ion binding]; other site 510831001986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 510831001987 nucleotide binding region [chemical binding]; other site 510831001988 ATP-binding site [chemical binding]; other site 510831001989 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 510831001990 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 510831001991 YccA-like proteins; Region: YccA_like; cd10433 510831001992 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 510831001993 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 510831001994 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 510831001995 minor groove reading motif; other site 510831001996 helix-hairpin-helix signature motif; other site 510831001997 substrate binding pocket [chemical binding]; other site 510831001998 active site 510831001999 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 510831002000 ferredoxin; Provisional; Region: PRK08764 510831002001 Putative Fe-S cluster; Region: FeS; cl17515 510831002002 4Fe-4S binding domain; Region: Fer4; pfam00037 510831002003 glutaredoxin 2; Provisional; Region: PRK10387 510831002004 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 510831002005 C-terminal domain interface [polypeptide binding]; other site 510831002006 GSH binding site (G-site) [chemical binding]; other site 510831002007 catalytic residues [active] 510831002008 putative dimer interface [polypeptide binding]; other site 510831002009 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 510831002010 N-terminal domain interface [polypeptide binding]; other site 510831002011 POT family; Region: PTR2; cl17359 510831002012 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 510831002013 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 510831002014 Ferritin-like domain; Region: Ferritin; pfam00210 510831002015 ferroxidase diiron center [ion binding]; other site 510831002016 lipoyl synthase; Provisional; Region: PRK05481 510831002017 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 510831002018 FeS/SAM binding site; other site 510831002019 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 510831002020 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 510831002021 conserved cys residue [active] 510831002022 hypothetical protein; Validated; Region: PRK00110 510831002023 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 510831002024 active site 510831002025 putative DNA-binding cleft [nucleotide binding]; other site 510831002026 dimer interface [polypeptide binding]; other site 510831002027 potential frameshift: common BLAST hit: gi|89256282|ref|YP_513644.1| major facilitator superfamily (MFS) transport protein 510831002028 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 510831002029 RuvA N terminal domain; Region: RuvA_N; pfam01330 510831002030 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 510831002031 RmuC family; Region: RmuC; pfam02646 510831002032 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 510831002033 dimerization interface [polypeptide binding]; other site 510831002034 putative Zn2+ binding site [ion binding]; other site 510831002035 putative DNA binding site [nucleotide binding]; other site 510831002036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 510831002037 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 510831002038 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 510831002039 histidine decarboxylase; Provisional; Region: PRK02769 510831002040 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 510831002041 catalytic residue [active] 510831002042 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 510831002043 intersubunit interface [polypeptide binding]; other site 510831002044 active site 510831002045 Zn2+ binding site [ion binding]; other site 510831002046 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 510831002047 active site 510831002048 DNA binding site [nucleotide binding] 510831002049 Isochorismatase family; Region: Isochorismatase; pfam00857 510831002050 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 510831002051 catalytic triad [active] 510831002052 conserved cis-peptide bond; other site 510831002053 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 510831002054 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 510831002055 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 510831002056 Mechanosensitive ion channel; Region: MS_channel; pfam00924 510831002057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831002058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 510831002059 putative substrate translocation pore; other site 510831002060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831002061 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 510831002062 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 510831002063 putative active site [active] 510831002064 Zn binding site [ion binding]; other site 510831002065 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 510831002066 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 510831002067 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 510831002068 active site 510831002069 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 510831002070 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 510831002071 5S rRNA interface [nucleotide binding]; other site 510831002072 CTC domain interface [polypeptide binding]; other site 510831002073 L16 interface [polypeptide binding]; other site 510831002074 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 510831002075 Domain of unknown function DUF21; Region: DUF21; pfam01595 510831002076 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 510831002077 Transporter associated domain; Region: CorC_HlyC; pfam03471 510831002078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 510831002079 Methyltransferase domain; Region: Methyltransf_31; pfam13847 510831002080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 510831002081 S-adenosylmethionine binding site [chemical binding]; other site 510831002082 GTP-binding protein YchF; Reviewed; Region: PRK09601 510831002083 YchF GTPase; Region: YchF; cd01900 510831002084 G1 box; other site 510831002085 GTP/Mg2+ binding site [chemical binding]; other site 510831002086 Switch I region; other site 510831002087 G2 box; other site 510831002088 Switch II region; other site 510831002089 G3 box; other site 510831002090 G4 box; other site 510831002091 G5 box; other site 510831002092 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 510831002093 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 510831002094 putative active site [active] 510831002095 catalytic residue [active] 510831002096 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 510831002097 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 510831002098 dimerization domain [polypeptide binding]; other site 510831002099 dimer interface [polypeptide binding]; other site 510831002100 catalytic residues [active] 510831002101 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 510831002102 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 510831002103 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 510831002104 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 510831002105 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 510831002106 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 510831002107 voltage-gated potassium channel; Provisional; Region: PRK10537 510831002108 Ion channel; Region: Ion_trans_2; pfam07885 510831002109 POT family; Region: PTR2; cl17359 510831002110 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 510831002111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 510831002112 Walker A motif; other site 510831002113 ATP binding site [chemical binding]; other site 510831002114 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 510831002115 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 510831002116 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 510831002117 active site 510831002118 HslU subunit interaction site [polypeptide binding]; other site 510831002119 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 510831002120 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 510831002121 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 510831002122 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 510831002123 active site 510831002124 HIGH motif; other site 510831002125 dimer interface [polypeptide binding]; other site 510831002126 KMSKS motif; other site 510831002127 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 510831002128 RNA binding surface [nucleotide binding]; other site 510831002129 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831002130 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831002131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831002132 Winged helix-turn helix; Region: HTH_29; pfam13551 510831002133 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 510831002134 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 510831002135 DNA binding site [nucleotide binding] 510831002136 catalytic residue [active] 510831002137 H2TH interface [polypeptide binding]; other site 510831002138 putative catalytic residues [active] 510831002139 turnover-facilitating residue; other site 510831002140 intercalation triad [nucleotide binding]; other site 510831002141 8OG recognition residue [nucleotide binding]; other site 510831002142 putative reading head residues; other site 510831002143 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 510831002144 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 510831002145 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 510831002146 AMP-binding enzyme; Region: AMP-binding; pfam00501 510831002147 acyl-activating enzyme (AAE) consensus motif; other site 510831002148 putative AMP binding site [chemical binding]; other site 510831002149 MraW methylase family; Region: Methyltransf_5; cl17771 510831002150 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 510831002151 Cell division protein FtsL; Region: FtsL; cl11433 510831002152 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 510831002153 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 510831002154 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 510831002155 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 510831002156 16S/18S rRNA binding site [nucleotide binding]; other site 510831002157 S13e-L30e interaction site [polypeptide binding]; other site 510831002158 25S rRNA binding site [nucleotide binding]; other site 510831002159 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 510831002160 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 510831002161 oligomer interface [polypeptide binding]; other site 510831002162 RNA binding site [nucleotide binding]; other site 510831002163 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 510831002164 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 510831002165 RNase E interface [polypeptide binding]; other site 510831002166 trimer interface [polypeptide binding]; other site 510831002167 active site 510831002168 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 510831002169 putative nucleic acid binding region [nucleotide binding]; other site 510831002170 G-X-X-G motif; other site 510831002171 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 510831002172 RNA binding site [nucleotide binding]; other site 510831002173 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 510831002174 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 510831002175 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 510831002176 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 510831002177 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 510831002178 ATP-binding site [chemical binding]; other site 510831002179 Sugar specificity; other site 510831002180 Pyrimidine base specificity; other site 510831002181 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 510831002182 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 510831002183 TRAM domain; Region: TRAM; pfam01938 510831002184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 510831002185 S-adenosylmethionine binding site [chemical binding]; other site 510831002186 potential frameshift: common BLAST hit: gi|118497216|ref|YP_898266.1| ROK family protein 510831002187 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 510831002188 Major Facilitator Superfamily; Region: MFS_1; pfam07690 510831002189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831002190 putative substrate translocation pore; other site 510831002191 enolase; Provisional; Region: eno; PRK00077 510831002192 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 510831002193 dimer interface [polypeptide binding]; other site 510831002194 metal binding site [ion binding]; metal-binding site 510831002195 substrate binding pocket [chemical binding]; other site 510831002196 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 510831002197 Septum formation initiator; Region: DivIC; cl17659 510831002198 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 510831002199 substrate binding site; other site 510831002200 dimer interface; other site 510831002201 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 510831002202 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 510831002203 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 510831002204 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 510831002205 NAD(P) binding site [chemical binding]; other site 510831002206 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 510831002207 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 510831002208 substrate-cofactor binding pocket; other site 510831002209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 510831002210 catalytic residue [active] 510831002211 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 510831002212 Glyco_18 domain; Region: Glyco_18; smart00636 510831002213 active site 510831002214 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 510831002215 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 510831002216 aromatic chitin/cellulose binding site residues [chemical binding]; other site 510831002217 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 510831002218 aromatic chitin/cellulose binding site residues [chemical binding]; other site 510831002219 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 510831002220 active site 510831002221 potential frameshift: common BLAST hit: gi|118497226|ref|YP_898276.1| formyltetrahydrofolate deformylase 510831002222 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 510831002223 putative substrate binding pocket [chemical binding]; other site 510831002224 trimer interface [polypeptide binding]; other site 510831002225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831002226 metabolite-proton symporter; Region: 2A0106; TIGR00883 510831002227 putative substrate translocation pore; other site 510831002228 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 510831002229 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 510831002230 Zn2+ binding site [ion binding]; other site 510831002231 Mg2+ binding site [ion binding]; other site 510831002232 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 510831002233 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 510831002234 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 510831002235 heme binding site [chemical binding]; other site 510831002236 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 510831002237 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831002238 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831002239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831002240 Winged helix-turn helix; Region: HTH_29; pfam13551 510831002241 classical (c) SDRs; Region: SDR_c; cd05233 510831002242 NAD(P) binding site [chemical binding]; other site 510831002243 active site 510831002244 potential frameshift: common BLAST hit: gi|134302386|ref|YP_001122355.1| D-alanyl-D-alanine 510831002245 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 510831002246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831002247 putative substrate translocation pore; other site 510831002248 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 510831002249 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 510831002250 active site 510831002251 catalytic site [active] 510831002252 metal binding site [ion binding]; metal-binding site 510831002253 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 510831002254 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 510831002255 Walker A/P-loop; other site 510831002256 ATP binding site [chemical binding]; other site 510831002257 Q-loop/lid; other site 510831002258 ABC transporter signature motif; other site 510831002259 Walker B; other site 510831002260 D-loop; other site 510831002261 H-loop/switch region; other site 510831002262 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 510831002263 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 510831002264 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 510831002265 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831002266 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831002267 Chorismate mutase type II; Region: CM_2; smart00830 510831002268 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 510831002269 catalytic residues [active] 510831002270 dimer interface [polypeptide binding]; other site 510831002271 potential frameshift: common BLAST hit: gi|109900470|ref|YP_663725.1| protein of unknown function DUF819 510831002272 potential frameshift: common BLAST hit: gi|134301694|ref|YP_001121662.1| Mandelate racemase / muconate lactonizing enzyme 510831002273 potential frameshift: common BLAST hit: gi|118497296|ref|YP_898346.1| predicted enzyme of enolase superfamily 510831002274 Putative serine esterase (DUF676); Region: DUF676; pfam05057 510831002275 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 510831002276 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 510831002277 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 510831002278 putative substrate binding site [chemical binding]; other site 510831002279 putative ATP binding site [chemical binding]; other site 510831002280 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 510831002281 RNA binding surface [nucleotide binding]; other site 510831002282 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 510831002283 OstA-like protein; Region: OstA; cl00844 510831002284 Organic solvent tolerance protein; Region: OstA_C; pfam04453 510831002285 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 510831002286 Fusaric acid resistance protein family; Region: FUSC; pfam04632 510831002287 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 510831002288 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 510831002289 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 510831002290 HlyD family secretion protein; Region: HlyD_3; pfam13437 510831002291 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 510831002292 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 510831002293 non-specific DNA interactions [nucleotide binding]; other site 510831002294 DNA binding site [nucleotide binding] 510831002295 sequence specific DNA binding site [nucleotide binding]; other site 510831002296 putative cAMP binding site [chemical binding]; other site 510831002297 Bacterial transcriptional regulator; Region: IclR; pfam01614 510831002298 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 510831002299 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 510831002300 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 510831002301 Radical SAM superfamily; Region: Radical_SAM; pfam04055 510831002302 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 510831002303 FeS/SAM binding site; other site 510831002304 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 510831002305 DNA-binding site [nucleotide binding]; DNA binding site 510831002306 RNA-binding motif; other site 510831002307 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 510831002308 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 510831002309 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 510831002310 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 510831002311 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 510831002312 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 510831002313 active site 510831002314 tetramer interface; other site 510831002315 potential frameshift: common BLAST hit: gi|118497325|ref|YP_898375.1| acyl-coenzyme A synthetase/AMP-(fatty) acid ligase 510831002316 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 510831002317 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 510831002318 active site 510831002319 CoA binding site [chemical binding]; other site 510831002320 AMP binding site [chemical binding]; other site 510831002321 EamA-like transporter family; Region: EamA; pfam00892 510831002322 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 510831002323 EamA-like transporter family; Region: EamA; pfam00892 510831002324 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 510831002325 recombination protein F; Reviewed; Region: recF; PRK00064 510831002326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 510831002327 Walker A/P-loop; other site 510831002328 ATP binding site [chemical binding]; other site 510831002329 Q-loop/lid; other site 510831002330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 510831002331 ABC transporter signature motif; other site 510831002332 Walker B; other site 510831002333 D-loop; other site 510831002334 H-loop/switch region; other site 510831002335 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 510831002336 active site 510831002337 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 510831002338 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 510831002339 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831002340 Winged helix-turn helix; Region: HTH_29; pfam13551 510831002341 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831002342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831002343 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 510831002344 LPP20 lipoprotein; Region: LPP20; cl15824 510831002345 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 510831002346 DEAD/DEAH box helicase; Region: DEAD; pfam00270 510831002347 ATP binding site [chemical binding]; other site 510831002348 putative Mg++ binding site [ion binding]; other site 510831002349 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 510831002350 SEC-C motif; Region: SEC-C; pfam02810 510831002351 potential frameshift: common BLAST hit: gi|118497269|ref|YP_898319.1| 3-methyladenine DNA glycosylase 510831002352 potential frameshift: common BLAST hit: gi|118497270|ref|YP_898320.1| glycerate kinase 510831002353 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 510831002354 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 510831002355 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 510831002356 potential frameshift: common BLAST hit: gi|156502904|ref|YP_001428968.1| major facilitator superfamily 510831002357 ribonuclease D; Region: rnd; TIGR01388 510831002358 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 510831002359 catalytic site [active] 510831002360 putative active site [active] 510831002361 putative substrate binding site [chemical binding]; other site 510831002362 HRDC domain; Region: HRDC; pfam00570 510831002363 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 510831002364 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 510831002365 GIY-YIG motif/motif A; other site 510831002366 active site 510831002367 catalytic site [active] 510831002368 putative DNA binding site [nucleotide binding]; other site 510831002369 metal binding site [ion binding]; metal-binding site 510831002370 UvrB/uvrC motif; Region: UVR; pfam02151 510831002371 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 510831002372 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831002373 Winged helix-turn helix; Region: HTH_29; pfam13551 510831002374 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831002375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831002376 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 510831002377 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 510831002378 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 510831002379 NAD binding site [chemical binding]; other site 510831002380 homotetramer interface [polypeptide binding]; other site 510831002381 homodimer interface [polypeptide binding]; other site 510831002382 substrate binding site [chemical binding]; other site 510831002383 active site 510831002384 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 510831002385 hypothetical protein; Provisional; Region: PRK05409 510831002386 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 510831002387 DoxX; Region: DoxX; pfam07681 510831002388 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 510831002389 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 510831002390 putative active site [active] 510831002391 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 510831002392 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 510831002393 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 510831002394 substrate binding site [chemical binding]; other site 510831002395 hexamer interface [polypeptide binding]; other site 510831002396 metal binding site [ion binding]; metal-binding site 510831002397 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 510831002398 Bacterial sugar transferase; Region: Bac_transf; pfam02397 510831002399 UDP-glucose 4-epimerase; Region: PLN02240 510831002400 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 510831002401 NAD binding site [chemical binding]; other site 510831002402 homodimer interface [polypeptide binding]; other site 510831002403 active site 510831002404 substrate binding site [chemical binding]; other site 510831002405 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 510831002406 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 510831002407 putative ADP-binding pocket [chemical binding]; other site 510831002408 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 510831002409 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 510831002410 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 510831002411 Walker A/P-loop; other site 510831002412 ATP binding site [chemical binding]; other site 510831002413 Q-loop/lid; other site 510831002414 ABC transporter signature motif; other site 510831002415 Walker B; other site 510831002416 D-loop; other site 510831002417 H-loop/switch region; other site 510831002418 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 510831002419 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 510831002420 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 510831002421 active site 510831002422 Methyltransferase domain; Region: Methyltransf_23; pfam13489 510831002423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 510831002424 S-adenosylmethionine binding site [chemical binding]; other site 510831002425 LicD family; Region: LicD; pfam04991 510831002426 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 510831002427 active site 510831002428 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 510831002429 active site 510831002430 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 510831002431 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 510831002432 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 510831002433 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 510831002434 motif II; other site 510831002435 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 510831002436 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 510831002437 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 510831002438 substrate binding site [chemical binding]; other site 510831002439 ATP binding site [chemical binding]; other site 510831002440 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 510831002441 proposed catalytic triad [active] 510831002442 active site nucleophile [active] 510831002443 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 510831002444 catalytic nucleophile [active] 510831002445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831002446 metabolite-proton symporter; Region: 2A0106; TIGR00883 510831002447 putative substrate translocation pore; other site 510831002448 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 510831002449 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 510831002450 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 510831002451 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 510831002452 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 510831002453 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 510831002454 Zn2+ binding site [ion binding]; other site 510831002455 Mg2+ binding site [ion binding]; other site 510831002456 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 510831002457 synthetase active site [active] 510831002458 NTP binding site [chemical binding]; other site 510831002459 metal binding site [ion binding]; metal-binding site 510831002460 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 510831002461 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 510831002462 recombination protein RecR; Provisional; Region: PRK13844 510831002463 RecR protein; Region: RecR; pfam02132 510831002464 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 510831002465 putative active site [active] 510831002466 putative metal-binding site [ion binding]; other site 510831002467 tetramer interface [polypeptide binding]; other site 510831002468 hypothetical protein; Validated; Region: PRK00153 510831002469 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 510831002470 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 510831002471 homodimer interface [polypeptide binding]; other site 510831002472 active site 510831002473 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 510831002474 lipoyl attachment site [posttranslational modification]; other site 510831002475 potential frameshift: common BLAST hit: gi|134301671|ref|YP_001121639.1| chitin binding domain protein 510831002476 Chitin binding domain; Region: Chitin_bind_3; pfam03067 510831002477 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 510831002478 aromatic chitin/cellulose binding site residues [chemical binding]; other site 510831002479 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 510831002480 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 510831002481 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 510831002482 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 510831002483 active site 510831002484 dimer interface [polypeptide binding]; other site 510831002485 motif 1; other site 510831002486 motif 2; other site 510831002487 motif 3; other site 510831002488 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 510831002489 anticodon binding site; other site 510831002490 translation initiation factor IF-3; Region: infC; TIGR00168 510831002491 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 510831002492 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 510831002493 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 510831002494 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 510831002495 23S rRNA binding site [nucleotide binding]; other site 510831002496 L21 binding site [polypeptide binding]; other site 510831002497 L13 binding site [polypeptide binding]; other site 510831002498 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 510831002499 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831002500 Winged helix-turn helix; Region: HTH_29; pfam13551 510831002501 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831002502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831002503 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 510831002504 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 510831002505 nudix motif; other site 510831002506 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 510831002507 ArsC family; Region: ArsC; pfam03960 510831002508 catalytic residue [active] 510831002509 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 510831002510 potential frameshift: common BLAST hit: gi|156501707|ref|YP_001427772.1| L-aspartate-beta-decarboxylase 510831002511 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 510831002512 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 510831002513 TrkA-C domain; Region: TrkA_C; pfam02080 510831002514 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 510831002515 potential frameshift: common BLAST hit: gi|134302268|ref|YP_001122237.1| DNA processing protein DprA 510831002516 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 510831002517 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 510831002518 ligand binding site [chemical binding]; other site 510831002519 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 510831002520 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 510831002521 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 510831002522 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 510831002523 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 510831002524 homotrimer interaction site [polypeptide binding]; other site 510831002525 active site 510831002526 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 510831002527 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 510831002528 TolQ protein; Region: tolQ; TIGR02796 510831002529 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 510831002530 TolR protein; Region: tolR; TIGR02801 510831002531 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 510831002532 TolB amino-terminal domain; Region: TolB_N; pfam04052 510831002533 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 510831002534 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 510831002535 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 510831002536 ligand binding site [chemical binding]; other site 510831002537 potential frameshift: common BLAST hit: gi|118496968|ref|YP_898018.1| tRNA-methylthiotransferase MiaB protein 510831002538 potential frameshift: common BLAST hit: gi|118496969|ref|YP_898019.1| short-chain alcohol dehydrogenase-like dehydrogenase 510831002539 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 510831002540 DNA photolyase; Region: DNA_photolyase; pfam00875 510831002541 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 510831002542 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 510831002543 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 510831002544 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 510831002545 bile acid transporter; Region: bass; TIGR00841 510831002546 Sodium Bile acid symporter family; Region: SBF; cl17470 510831002547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 510831002548 YheO-like PAS domain; Region: PAS_6; pfam08348 510831002549 HTH domain; Region: HTH_22; pfam13309 510831002550 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 510831002551 hypothetical protein; Provisional; Region: PRK10621 510831002552 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 510831002553 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 510831002554 transmembrane helices; other site 510831002555 Protein of unknown function (DUF423); Region: DUF423; pfam04241 510831002556 Protein of unknown function, DUF393; Region: DUF393; pfam04134 510831002557 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 510831002558 UbiA prenyltransferase family; Region: UbiA; pfam01040 510831002559 Chorismate lyase; Region: Chor_lyase; cl01230 510831002560 ribonuclease PH; Reviewed; Region: rph; PRK00173 510831002561 Ribonuclease PH; Region: RNase_PH_bact; cd11362 510831002562 hexamer interface [polypeptide binding]; other site 510831002563 active site 510831002564 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 510831002565 heat shock protein HtpX; Provisional; Region: PRK02870 510831002566 LemA family; Region: LemA; cl00742 510831002567 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 510831002568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 510831002569 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 510831002570 putative dimerization interface [polypeptide binding]; other site 510831002571 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 510831002572 Soluble P-type ATPase [General function prediction only]; Region: COG4087 510831002573 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 510831002574 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831002575 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831002576 potential frameshift: common BLAST hit: gi|118497001|ref|YP_898051.1| heavy metal cation transport ATPase 510831002577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 510831002578 dimerization interface [polypeptide binding]; other site 510831002579 putative DNA binding site [nucleotide binding]; other site 510831002580 putative Zn2+ binding site [ion binding]; other site 510831002581 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 510831002582 putative active site [active] 510831002583 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 510831002584 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 510831002585 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 510831002586 Colicin V production protein; Region: Colicin_V; pfam02674 510831002587 DNA repair protein RadA; Provisional; Region: PRK11823 510831002588 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 510831002589 Walker A motif/ATP binding site; other site 510831002590 ATP binding site [chemical binding]; other site 510831002591 Walker B motif; other site 510831002592 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 510831002593 PilZ domain; Region: PilZ; pfam07238 510831002594 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 510831002595 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 510831002596 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 510831002597 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 510831002598 Tetramer interface [polypeptide binding]; other site 510831002599 active site 510831002600 FMN-binding site [chemical binding]; other site 510831002601 potential frameshift: common BLAST hit: gi|156501769|ref|YP_001427834.1| PQ loop repeat family 510831002602 methionine sulfoxide reductase B; Provisional; Region: PRK00222 510831002603 SelR domain; Region: SelR; pfam01641 510831002604 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 510831002605 E-class dimer interface [polypeptide binding]; other site 510831002606 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 510831002607 P-class dimer interface [polypeptide binding]; other site 510831002608 active site 510831002609 Cu2+ binding site [ion binding]; other site 510831002610 Zn2+ binding site [ion binding]; other site 510831002611 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 510831002612 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 510831002613 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 510831002614 Cupin domain; Region: Cupin_2; cl17218 510831002615 potential frameshift: common BLAST hit: gi|118497016|ref|YP_898066.1| Zn-dependent alcohol dehydrogenase 510831002616 aspartate aminotransferase; Provisional; Region: PRK07568 510831002617 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 510831002618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 510831002619 homodimer interface [polypeptide binding]; other site 510831002620 catalytic residue [active] 510831002621 Cation efflux family; Region: Cation_efflux; pfam01545 510831002622 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 510831002623 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 510831002624 Walker A/P-loop; other site 510831002625 ATP binding site [chemical binding]; other site 510831002626 Q-loop/lid; other site 510831002627 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 510831002628 ABC transporter signature motif; other site 510831002629 Walker B; other site 510831002630 D-loop; other site 510831002631 H-loop/switch region; other site 510831002632 potential frameshift: common BLAST hit: gi|89255801|ref|YP_513163.1| Type IV pili fiber building block protein 510831002633 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 510831002634 Pilin (bacterial filament); Region: Pilin; pfam00114 510831002635 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 510831002636 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 510831002637 Pilin (bacterial filament); Region: Pilin; pfam00114 510831002638 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 510831002639 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 510831002640 active site 510831002641 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 510831002642 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 510831002643 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 510831002644 homodimer interface [polypeptide binding]; other site 510831002645 NADP binding site [chemical binding]; other site 510831002646 substrate binding site [chemical binding]; other site 510831002647 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 510831002648 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 510831002649 dimerization interface [polypeptide binding]; other site 510831002650 putative ATP binding site [chemical binding]; other site 510831002651 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 510831002652 active site 510831002653 ATP binding site [chemical binding]; other site 510831002654 substrate binding site [chemical binding]; other site 510831002655 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 510831002656 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 510831002657 ATP-grasp domain; Region: ATP-grasp_4; cl17255 510831002658 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 510831002659 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 510831002660 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 510831002661 active site 510831002662 substrate binding site [chemical binding]; other site 510831002663 cosubstrate binding site; other site 510831002664 catalytic site [active] 510831002665 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 510831002666 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 510831002667 ATP-grasp domain; Region: ATP-grasp; pfam02222 510831002668 hypothetical protein; Provisional; Region: PRK14682 510831002669 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 510831002670 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 510831002671 active site 510831002672 Zn binding site [ion binding]; other site 510831002673 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 510831002674 hypothetical protein; Provisional; Region: PRK11281 510831002675 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 510831002676 O-Antigen ligase; Region: Wzy_C; cl04850 510831002677 DNA topoisomerase I; Validated; Region: PRK06599 510831002678 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 510831002679 active site 510831002680 interdomain interaction site; other site 510831002681 putative metal-binding site [ion binding]; other site 510831002682 nucleotide binding site [chemical binding]; other site 510831002683 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 510831002684 domain I; other site 510831002685 DNA binding groove [nucleotide binding] 510831002686 phosphate binding site [ion binding]; other site 510831002687 domain II; other site 510831002688 domain III; other site 510831002689 nucleotide binding site [chemical binding]; other site 510831002690 catalytic site [active] 510831002691 domain IV; other site 510831002692 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 510831002693 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 510831002694 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 510831002695 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 510831002696 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 510831002697 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 510831002698 P-loop; other site 510831002699 Magnesium ion binding site [ion binding]; other site 510831002700 ParB-like nuclease domain; Region: ParB; smart00470 510831002701 KorB domain; Region: KorB; pfam08535 510831002702 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 510831002703 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 510831002704 catalytic triad [active] 510831002705 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 510831002706 active site 510831002707 catalytic triad [active] 510831002708 oxyanion hole [active] 510831002709 HD domain; Region: HD_3; pfam13023 510831002710 FtsJ-like methyltransferase; Region: FtsJ; cl17430 510831002711 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 510831002712 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 510831002713 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 510831002714 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 510831002715 active site 510831002716 HIGH motif; other site 510831002717 nucleotide binding site [chemical binding]; other site 510831002718 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 510831002719 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 510831002720 active site 510831002721 KMSKS motif; other site 510831002722 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 510831002723 tRNA binding surface [nucleotide binding]; other site 510831002724 anticodon binding site; other site 510831002725 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 510831002726 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 510831002727 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 510831002728 active site 510831002729 Riboflavin kinase; Region: Flavokinase; pfam01687 510831002730 malate dehydrogenase; Provisional; Region: PRK13529 510831002731 Malic enzyme, N-terminal domain; Region: malic; pfam00390 510831002732 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 510831002733 NAD(P) binding pocket [chemical binding]; other site 510831002734 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 510831002735 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 510831002736 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831002737 Winged helix-turn helix; Region: HTH_29; pfam13551 510831002738 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831002739 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831002740 potential RNA location 932748...932824 (tRNA-V) and potential protein location 932281...932805 overlap by 58bp 510831002741 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 510831002742 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 510831002743 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 510831002744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 510831002745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 510831002746 S-adenosylmethionine binding site [chemical binding]; other site 510831002747 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 510831002748 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 510831002749 putative active site [active] 510831002750 substrate binding site [chemical binding]; other site 510831002751 putative cosubstrate binding site; other site 510831002752 catalytic site [active] 510831002753 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 510831002754 substrate binding site [chemical binding]; other site 510831002755 glutathione synthetase; Provisional; Region: PRK05246 510831002756 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 510831002757 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 510831002758 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 510831002759 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 510831002760 inhibitor-cofactor binding pocket; inhibition site 510831002761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 510831002762 catalytic residue [active] 510831002763 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 510831002764 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 510831002765 classical (c) SDRs; Region: SDR_c; cd05233 510831002766 NAD(P) binding site [chemical binding]; other site 510831002767 active site 510831002768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 510831002769 acetoacetate decarboxylase; Provisional; Region: PRK02265 510831002770 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 510831002771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831002772 putative substrate translocation pore; other site 510831002773 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 510831002774 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 510831002775 nucleotide binding site [chemical binding]; other site 510831002776 potential frameshift: common BLAST hit: gi|134301845|ref|YP_001121813.1| biotin-(acetyl-CoA-carboxylase) ligase 510831002777 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 510831002778 AAA domain; Region: AAA_26; pfam13500 510831002779 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 510831002780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 510831002781 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 510831002782 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 510831002783 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 510831002784 catalytic residue [active] 510831002785 biotin synthase; Region: bioB; TIGR00433 510831002786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 510831002787 FeS/SAM binding site; other site 510831002788 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 510831002789 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 510831002790 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 510831002791 inhibitor-cofactor binding pocket; inhibition site 510831002792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 510831002793 catalytic residue [active] 510831002794 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 510831002795 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 510831002796 active site 510831002797 purine riboside binding site [chemical binding]; other site 510831002798 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 510831002799 active site 2 [active] 510831002800 active site 1 [active] 510831002801 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 510831002802 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 510831002803 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 510831002804 catalytic center binding site [active] 510831002805 ATP binding site [chemical binding]; other site 510831002806 dihydropteroate synthase; Region: DHPS; TIGR01496 510831002807 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 510831002808 substrate binding pocket [chemical binding]; other site 510831002809 dimer interface [polypeptide binding]; other site 510831002810 inhibitor binding site; inhibition site 510831002811 Dihydroneopterin aldolase; Region: FolB; smart00905 510831002812 active site 510831002813 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 510831002814 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 510831002815 acyl-activating enzyme (AAE) consensus motif; other site 510831002816 AMP binding site [chemical binding]; other site 510831002817 active site 510831002818 CoA binding site [chemical binding]; other site 510831002819 aminodeoxychorismate synthase; Provisional; Region: PRK07508 510831002820 chorismate binding enzyme; Region: Chorismate_bind; cl10555 510831002821 Aminotransferase class IV; Region: Aminotran_4; pfam01063 510831002822 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 510831002823 substrate-cofactor binding pocket; other site 510831002824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 510831002825 catalytic residue [active] 510831002826 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 510831002827 Glutamine amidotransferase class-I; Region: GATase; pfam00117 510831002828 glutamine binding [chemical binding]; other site 510831002829 catalytic triad [active] 510831002830 potential frameshift: common BLAST hit: gi|167628018|ref|YP_001678518.1| major facilitator superfamily (MFS) transport protein [Francisella 510831002831 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 510831002832 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 510831002833 active site 510831002834 catalytic tetrad [active] 510831002835 Predicted amidohydrolase [General function prediction only]; Region: COG0388 510831002836 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 510831002837 active site 510831002838 catalytic triad [active] 510831002839 dimer interface [polypeptide binding]; other site 510831002840 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 510831002841 GTP cyclohydrolase I; Provisional; Region: PLN03044 510831002842 active site 510831002843 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 510831002844 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 510831002845 ATP binding site [chemical binding]; other site 510831002846 Mg++ binding site [ion binding]; other site 510831002847 motif III; other site 510831002848 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 510831002849 nucleotide binding region [chemical binding]; other site 510831002850 ATP-binding site [chemical binding]; other site 510831002851 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 510831002852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831002853 putative substrate translocation pore; other site 510831002854 POT family; Region: PTR2; cl17359 510831002855 Uncharacterized conserved protein [Function unknown]; Region: COG0393 510831002856 glutathione reductase; Validated; Region: PRK06116 510831002857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 510831002858 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 510831002859 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 510831002860 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 510831002861 AAA domain; Region: AAA_18; pfam13238 510831002862 short chain dehydrogenase; Provisional; Region: PRK07577 510831002863 classical (c) SDRs; Region: SDR_c; cd05233 510831002864 NAD(P) binding site [chemical binding]; other site 510831002865 active site 510831002866 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 510831002867 putative active site [active] 510831002868 putative catalytic site [active] 510831002869 putative DNA binding site [nucleotide binding]; other site 510831002870 putative phosphate binding site [ion binding]; other site 510831002871 metal binding site A [ion binding]; metal-binding site 510831002872 putative AP binding site [nucleotide binding]; other site 510831002873 putative metal binding site B [ion binding]; other site 510831002874 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 510831002875 active site 510831002876 Zn binding site [ion binding]; other site 510831002877 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 510831002878 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 510831002879 intracellular protease, PfpI family; Region: PfpI; TIGR01382 510831002880 potential catalytic triad [active] 510831002881 conserved cys residue [active] 510831002882 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 510831002883 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 510831002884 signal recognition particle protein; Provisional; Region: PRK10867 510831002885 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 510831002886 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 510831002887 P loop; other site 510831002888 GTP binding site [chemical binding]; other site 510831002889 Signal peptide binding domain; Region: SRP_SPB; pfam02978 510831002890 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 510831002891 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 510831002892 rRNA binding site [nucleotide binding]; other site 510831002893 predicted 30S ribosome binding site; other site 510831002894 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 510831002895 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 510831002896 TrkA-N domain; Region: TrkA_N; pfam02254 510831002897 TrkA-N domain; Region: TrkA_N; pfam02254 510831002898 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 510831002899 Transcriptional regulator; Region: Rrf2; pfam02082 510831002900 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 510831002901 putative ABC transporter; Region: ycf24; CHL00085 510831002902 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 510831002903 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 510831002904 Walker A/P-loop; other site 510831002905 ATP binding site [chemical binding]; other site 510831002906 Q-loop/lid; other site 510831002907 ABC transporter signature motif; other site 510831002908 Walker B; other site 510831002909 D-loop; other site 510831002910 H-loop/switch region; other site 510831002911 FeS assembly protein SufD; Region: sufD; TIGR01981 510831002912 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 510831002913 Amidinotransferase; Region: Amidinotransf; cl12043 510831002914 Amidinotransferase; Region: Amidinotransf; cl12043 510831002915 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 510831002916 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 510831002917 catalytic residues [active] 510831002918 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 510831002919 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 510831002920 Transcriptional regulators [Transcription]; Region: MarR; COG1846 510831002921 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 510831002922 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 510831002923 hypothetical protein; Provisional; Region: PRK07505 510831002924 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 510831002925 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 510831002926 catalytic residue [active] 510831002927 PAS fold; Region: PAS_4; pfam08448 510831002928 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 510831002929 active site 510831002930 8-oxo-dGMP binding site [chemical binding]; other site 510831002931 nudix motif; other site 510831002932 metal binding site [ion binding]; metal-binding site 510831002933 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 510831002934 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 510831002935 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 510831002936 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 510831002937 Transglutaminase/protease-like homologues; Region: TGc; smart00460 510831002938 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 510831002939 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 510831002940 HIGH motif; other site 510831002941 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 510831002942 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 510831002943 active site 510831002944 KMSKS motif; other site 510831002945 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 510831002946 tRNA binding surface [nucleotide binding]; other site 510831002947 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 510831002948 Lipopolysaccharide-assembly; Region: LptE; cl01125 510831002949 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 510831002950 Mechanosensitive ion channel; Region: MS_channel; pfam00924 510831002951 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 510831002952 trimer interface [polypeptide binding]; other site 510831002953 active site 510831002954 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 510831002955 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 510831002956 Walker A motif; other site 510831002957 metabolite-proton symporter; Region: 2A0106; TIGR00883 510831002958 potential frameshift: common BLAST hit: gi|156502638|ref|YP_001428703.1| cardiolipin synthetase 510831002959 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 510831002960 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 510831002961 putative active site [active] 510831002962 catalytic site [active] 510831002963 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 510831002964 putative active site [active] 510831002965 catalytic site [active] 510831002966 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 510831002967 potential frameshift: common BLAST hit: gi|134301902|ref|YP_001121871.1| metal cation transporter, zinc (Zn2+)-iron (Fe2+) permease (ZIP) 510831002968 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 510831002969 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 510831002970 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 510831002971 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 510831002972 metal binding site 2 [ion binding]; metal-binding site 510831002973 putative DNA binding helix; other site 510831002974 metal binding site 1 [ion binding]; metal-binding site 510831002975 dimer interface [polypeptide binding]; other site 510831002976 structural Zn2+ binding site [ion binding]; other site 510831002977 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 510831002978 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 510831002979 putative tRNA-binding site [nucleotide binding]; other site 510831002980 B3/4 domain; Region: B3_4; pfam03483 510831002981 tRNA synthetase B5 domain; Region: B5; smart00874 510831002982 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 510831002983 dimer interface [polypeptide binding]; other site 510831002984 motif 1; other site 510831002985 motif 3; other site 510831002986 motif 2; other site 510831002987 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 510831002988 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 510831002989 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 510831002990 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 510831002991 dimer interface [polypeptide binding]; other site 510831002992 motif 1; other site 510831002993 active site 510831002994 motif 2; other site 510831002995 motif 3; other site 510831002996 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 510831002997 EamA-like transporter family; Region: EamA; pfam00892 510831002998 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 510831002999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831003000 MFS/sugar transport protein; Region: MFS_2; pfam13347 510831003001 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 510831003002 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 510831003003 non-specific DNA binding site [nucleotide binding]; other site 510831003004 salt bridge; other site 510831003005 sequence-specific DNA binding site [nucleotide binding]; other site 510831003006 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 510831003007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 510831003008 Walker A motif; other site 510831003009 ATP binding site [chemical binding]; other site 510831003010 Walker B motif; other site 510831003011 arginine finger; other site 510831003012 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 510831003013 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 510831003014 classical (c) SDRs; Region: SDR_c; cd05233 510831003015 NAD(P) binding site [chemical binding]; other site 510831003016 active site 510831003017 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 510831003018 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 510831003019 active site 510831003020 catalytic triad [active] 510831003021 oxyanion hole [active] 510831003022 switch loop; other site 510831003023 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 510831003024 putative active site pocket [active] 510831003025 dimerization interface [polypeptide binding]; other site 510831003026 putative catalytic residue [active] 510831003027 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 510831003028 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 510831003029 TPP-binding site; other site 510831003030 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 510831003031 PYR/PP interface [polypeptide binding]; other site 510831003032 dimer interface [polypeptide binding]; other site 510831003033 TPP binding site [chemical binding]; other site 510831003034 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 510831003035 GMP synthase; Reviewed; Region: guaA; PRK00074 510831003036 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 510831003037 AMP/PPi binding site [chemical binding]; other site 510831003038 candidate oxyanion hole; other site 510831003039 catalytic triad [active] 510831003040 potential glutamine specificity residues [chemical binding]; other site 510831003041 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 510831003042 ATP Binding subdomain [chemical binding]; other site 510831003043 Ligand Binding sites [chemical binding]; other site 510831003044 Dimerization subdomain; other site 510831003045 amino acid transporter; Region: 2A0306; TIGR00909 510831003046 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 510831003047 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 510831003048 dimerization interface 3.5A [polypeptide binding]; other site 510831003049 active site 510831003050 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 510831003051 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 510831003052 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 510831003053 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 510831003054 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 510831003055 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 510831003056 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 510831003057 Walker A/P-loop; other site 510831003058 ATP binding site [chemical binding]; other site 510831003059 Q-loop/lid; other site 510831003060 ABC transporter signature motif; other site 510831003061 Walker B; other site 510831003062 D-loop; other site 510831003063 H-loop/switch region; other site 510831003064 OstA-like protein; Region: OstA; cl00844 510831003065 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 510831003066 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 510831003067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 510831003068 active site 510831003069 motif I; other site 510831003070 motif II; other site 510831003071 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 510831003072 dimer interface [polypeptide binding]; other site 510831003073 substrate binding site [chemical binding]; other site 510831003074 metal binding sites [ion binding]; metal-binding site 510831003075 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 510831003076 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 510831003077 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 510831003078 Protein of unknown function (DUF493); Region: DUF493; pfam04359 510831003079 lipoate-protein ligase B; Provisional; Region: PRK14342 510831003080 potential frameshift: common BLAST hit: gi|118497503|ref|YP_898553.1| glycosyl hydrolases family 31 protein 510831003081 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 510831003082 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 510831003083 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 510831003084 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 510831003085 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 510831003086 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 510831003087 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 510831003088 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 510831003089 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 510831003090 DNA binding residues [nucleotide binding] 510831003091 CHC2 zinc finger; Region: zf-CHC2; pfam01807 510831003092 DNA primase; Validated; Region: dnaG; PRK05667 510831003093 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 510831003094 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 510831003095 active site 510831003096 metal binding site [ion binding]; metal-binding site 510831003097 interdomain interaction site; other site 510831003098 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 510831003099 Yqey-like protein; Region: YqeY; pfam09424 510831003100 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 510831003101 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 510831003102 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 510831003103 N-acetyl-D-glucosamine binding site [chemical binding]; other site 510831003104 catalytic residue [active] 510831003105 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 510831003106 active site 510831003107 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 510831003108 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 510831003109 Ligand Binding Site [chemical binding]; other site 510831003110 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 510831003111 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 510831003112 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 510831003113 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 510831003114 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 510831003115 substrate binding pocket [chemical binding]; other site 510831003116 chain length determination region; other site 510831003117 substrate-Mg2+ binding site; other site 510831003118 catalytic residues [active] 510831003119 aspartate-rich region 1; other site 510831003120 active site lid residues [active] 510831003121 aspartate-rich region 2; other site 510831003122 PQ loop repeat; Region: PQ-loop; cl17546 510831003123 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 510831003124 ligand-binding site [chemical binding]; other site 510831003125 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 510831003126 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 510831003127 CysD dimerization site [polypeptide binding]; other site 510831003128 G1 box; other site 510831003129 putative GEF interaction site [polypeptide binding]; other site 510831003130 GTP/Mg2+ binding site [chemical binding]; other site 510831003131 Switch I region; other site 510831003132 G2 box; other site 510831003133 G3 box; other site 510831003134 Switch II region; other site 510831003135 G4 box; other site 510831003136 G5 box; other site 510831003137 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 510831003138 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 510831003139 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 510831003140 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 510831003141 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 510831003142 preprotein translocase subunit SecA; Validated; Region: secA; CHL00122 510831003143 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 510831003144 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 510831003145 RNA binding surface [nucleotide binding]; other site 510831003146 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 510831003147 probable active site [active] 510831003148 Tetratricopeptide repeat; Region: TPR_12; pfam13424 510831003149 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 510831003150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 510831003151 FeS/SAM binding site; other site 510831003152 replicative DNA helicase; Region: DnaB; TIGR00665 510831003153 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 510831003154 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 510831003155 Walker A motif; other site 510831003156 ATP binding site [chemical binding]; other site 510831003157 Walker B motif; other site 510831003158 DNA binding loops [nucleotide binding] 510831003159 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 510831003160 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 510831003161 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 510831003162 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 510831003163 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 510831003164 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 510831003165 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 510831003166 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 510831003167 catalytic core [active] 510831003168 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831003169 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831003170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831003171 Winged helix-turn helix; Region: HTH_29; pfam13551 510831003172 potential frameshift: common BLAST hit: gi|163868947|ref|YP_001610176.1| restriction enzyme of type III restriction-modification system 510831003173 potential frameshift: common BLAST hit: gi|163868947|ref|YP_001610176.1| restriction enzyme of type III restriction-modification system 510831003174 Abi-like protein; Region: Abi_2; cl01988 510831003175 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 510831003176 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 510831003177 putative active site [active] 510831003178 catalytic site [active] 510831003179 DEAD-like helicases superfamily; Region: DEXDc; smart00487 510831003180 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 510831003181 ATP binding site [chemical binding]; other site 510831003182 putative Mg++ binding site [ion binding]; other site 510831003183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 510831003184 nucleotide binding region [chemical binding]; other site 510831003185 ATP-binding site [chemical binding]; other site 510831003186 Antirestriction protein (ArdA); Region: ArdA; pfam07275 510831003187 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831003188 Winged helix-turn helix; Region: HTH_29; pfam13551 510831003189 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831003190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831003191 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 510831003192 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 510831003193 non-specific DNA binding site [nucleotide binding]; other site 510831003194 salt bridge; other site 510831003195 sequence-specific DNA binding site [nucleotide binding]; other site 510831003196 HipA N-terminal domain; Region: couple_hipA; TIGR03071 510831003197 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 510831003198 HipA-like N-terminal domain; Region: HipA_N; pfam07805 510831003199 HipA-like C-terminal domain; Region: HipA_C; pfam07804 510831003200 potential frameshift: common BLAST hit: gi|156502551|ref|YP_001428616.1| thrombospondin type 3 repeat family 510831003201 recombination associated protein; Reviewed; Region: rdgC; PRK00321 510831003202 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 510831003203 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 510831003204 active site residue [active] 510831003205 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 510831003206 S1 domain; Region: S1_2; pfam13509 510831003207 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 510831003208 Part of AAA domain; Region: AAA_19; pfam13245 510831003209 AAA domain; Region: AAA_14; pfam13173 510831003210 Family description; Region: UvrD_C_2; pfam13538 510831003211 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 510831003212 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 510831003213 Isochorismatase family; Region: Isochorismatase; pfam00857 510831003214 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 510831003215 catalytic triad [active] 510831003216 conserved cis-peptide bond; other site 510831003217 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 510831003218 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 510831003219 Isochorismatase family; Region: Isochorismatase; pfam00857 510831003220 catalytic triad [active] 510831003221 conserved cis-peptide bond; other site 510831003222 transaldolase-like protein; Provisional; Region: PTZ00411 510831003223 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 510831003224 active site 510831003225 dimer interface [polypeptide binding]; other site 510831003226 catalytic residue [active] 510831003227 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 510831003228 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 510831003229 interface (dimer of trimers) [polypeptide binding]; other site 510831003230 Substrate-binding/catalytic site; other site 510831003231 Zn-binding sites [ion binding]; other site 510831003232 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 510831003233 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 510831003234 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 510831003235 motif 1; other site 510831003236 active site 510831003237 motif 2; other site 510831003238 motif 3; other site 510831003239 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 510831003240 potential frameshift: common BLAST hit: gi|134302306|ref|YP_001122275.1| UvrD/REP helicase 510831003241 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 510831003242 potential frameshift: common BLAST hit: gi|118497368|ref|YP_898418.1| 4Fe-4S ferredoxin 510831003243 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 510831003244 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 510831003245 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 510831003246 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 510831003247 catalytic residues [active] 510831003248 potential frameshift: common BLAST hit: gi|118497365|ref|YP_898415.1| drug:H+ antiporter-1 (DHA1) family protein 510831003249 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 510831003250 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 510831003251 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 510831003252 TspO/MBR family; Region: TspO_MBR; pfam03073 510831003253 potential frameshift: common BLAST hit: gi|118497362|ref|YP_898412.1| betaine/carnitine/choline transporter (BCCT) family protein 510831003254 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 510831003255 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 510831003256 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 510831003257 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 510831003258 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 510831003259 active site 510831003260 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 510831003261 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831003262 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831003263 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 510831003264 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 510831003265 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 510831003266 DNA binding residues [nucleotide binding] 510831003267 Src Homology 3 domain superfamily; Region: SH3; cl17036 510831003268 peptide ligand binding site [polypeptide binding]; other site 510831003269 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 510831003270 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 510831003271 Protein export membrane protein; Region: SecD_SecF; pfam02355 510831003272 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 510831003273 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 510831003274 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 510831003275 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 510831003276 Isochorismatase family; Region: Isochorismatase; pfam00857 510831003277 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 510831003278 catalytic triad [active] 510831003279 conserved cis-peptide bond; other site 510831003280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 510831003281 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 510831003282 dimerization interface [polypeptide binding]; other site 510831003283 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 510831003284 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 510831003285 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 510831003286 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 510831003287 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 510831003288 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 510831003289 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 510831003290 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 510831003291 Walker A/P-loop; other site 510831003292 ATP binding site [chemical binding]; other site 510831003293 Q-loop/lid; other site 510831003294 ABC transporter signature motif; other site 510831003295 Walker B; other site 510831003296 D-loop; other site 510831003297 H-loop/switch region; other site 510831003298 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 510831003299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 510831003300 dimer interface [polypeptide binding]; other site 510831003301 conserved gate region; other site 510831003302 ABC-ATPase subunit interface; other site 510831003303 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 510831003304 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 510831003305 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 510831003306 aromatic amino acid transport protein; Region: araaP; TIGR00837 510831003307 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 510831003308 active site residue [active] 510831003309 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 510831003310 active site residue [active] 510831003311 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 510831003312 homotrimer interaction site [polypeptide binding]; other site 510831003313 zinc binding site [ion binding]; other site 510831003314 CDP-binding sites; other site 510831003315 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 510831003316 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 510831003317 cyanophycin synthetase; Provisional; Region: PRK14016 510831003318 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 510831003319 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 510831003320 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 510831003321 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 510831003322 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 510831003323 putative MPT binding site; other site 510831003324 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 510831003325 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 510831003326 active site 510831003327 catalytic site [active] 510831003328 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 510831003329 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 510831003330 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 510831003331 Walker A motif; other site 510831003332 ATP binding site [chemical binding]; other site 510831003333 Walker B motif; other site 510831003334 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 510831003335 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 510831003336 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 510831003337 potential frameshift: common BLAST hit: gi|118497707|ref|YP_898757.1| ATP binding protein 510831003338 ferrochelatase; Reviewed; Region: hemH; PRK00035 510831003339 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 510831003340 C-terminal domain interface [polypeptide binding]; other site 510831003341 active site 510831003342 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 510831003343 active site 510831003344 N-terminal domain interface [polypeptide binding]; other site 510831003345 potential frameshift: common BLAST hit: gi|134302129|ref|YP_001122098.1| deoxyribodipyrimidine photolyase 510831003346 PRC-barrel domain; Region: PRC; pfam05239 510831003347 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831003348 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831003349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831003350 Winged helix-turn helix; Region: HTH_29; pfam13551 510831003351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 510831003352 NAD(P) binding site [chemical binding]; other site 510831003353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 510831003354 active site 510831003355 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 510831003356 potential frameshift: common BLAST hit: gi|118497717|ref|YP_898767.1| aldose 1-epimerase 510831003357 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 510831003358 Flavoprotein; Region: Flavoprotein; pfam02441 510831003359 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 510831003360 benzoate transport; Region: 2A0115; TIGR00895 510831003361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831003362 putative substrate translocation pore; other site 510831003363 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 510831003364 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 510831003365 Proline dehydrogenase; Region: Pro_dh; pfam01619 510831003366 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 510831003367 Glutamate binding site [chemical binding]; other site 510831003368 NAD binding site [chemical binding]; other site 510831003369 catalytic residues [active] 510831003370 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 510831003371 NAD(P) binding site [chemical binding]; other site 510831003372 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 510831003373 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 510831003374 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 510831003375 active site 510831003376 dimer interface [polypeptide binding]; other site 510831003377 metal binding site [ion binding]; metal-binding site 510831003378 shikimate kinase; Reviewed; Region: aroK; PRK00131 510831003379 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 510831003380 ADP binding site [chemical binding]; other site 510831003381 magnesium binding site [ion binding]; other site 510831003382 putative shikimate binding site; other site 510831003383 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 510831003384 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 510831003385 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 510831003386 Pilus assembly protein, PilP; Region: PilP; pfam04351 510831003387 Pilus assembly protein, PilO; Region: PilO; cl01234 510831003388 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 510831003389 adenylate kinase; Reviewed; Region: adk; PRK00279 510831003390 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 510831003391 AMP-binding site [chemical binding]; other site 510831003392 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 510831003393 potential frameshift: common BLAST hit: gi|118497733|ref|YP_898783.1| 4Fe-4S ferredoxin, FAD dependent 510831003394 potential frameshift: common BLAST hit: gi|118497733|ref|YP_898783.1| 4Fe-4S ferredoxin, FAD dependent 510831003395 GTPase Era; Reviewed; Region: era; PRK00089 510831003396 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 510831003397 G1 box; other site 510831003398 GTP/Mg2+ binding site [chemical binding]; other site 510831003399 Switch I region; other site 510831003400 G2 box; other site 510831003401 Switch II region; other site 510831003402 G3 box; other site 510831003403 G4 box; other site 510831003404 G5 box; other site 510831003405 aspartate aminotransferase; Provisional; Region: PRK05764 510831003406 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 510831003407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 510831003408 homodimer interface [polypeptide binding]; other site 510831003409 catalytic residue [active] 510831003410 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 510831003411 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 510831003412 putative active site [active] 510831003413 putative dimer interface [polypeptide binding]; other site 510831003414 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 510831003415 Glycoprotease family; Region: Peptidase_M22; pfam00814 510831003416 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 510831003417 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 510831003418 active site 510831003419 dimer interface [polypeptide binding]; other site 510831003420 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 510831003421 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 510831003422 GTP/Mg2+ binding site [chemical binding]; other site 510831003423 G4 box; other site 510831003424 G5 box; other site 510831003425 G1 box; other site 510831003426 Switch I region; other site 510831003427 G2 box; other site 510831003428 G3 box; other site 510831003429 Switch II region; other site 510831003430 Sel1 repeat; Region: Sel1; cl02723 510831003431 HsdM N-terminal domain; Region: HsdM_N; pfam12161 510831003432 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 510831003433 Methyltransferase domain; Region: Methyltransf_26; pfam13659 510831003434 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 510831003435 DNA-binding site [nucleotide binding]; DNA binding site 510831003436 RNA-binding motif; other site 510831003437 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 510831003438 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 510831003439 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 510831003440 potential frameshift: common BLAST hit: gi|118497745|ref|YP_898795.1| type I restriction-modification system, subunit R (restriction) 510831003441 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 510831003442 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 510831003443 G1 box; other site 510831003444 putative GEF interaction site [polypeptide binding]; other site 510831003445 GTP/Mg2+ binding site [chemical binding]; other site 510831003446 Switch I region; other site 510831003447 G2 box; other site 510831003448 G3 box; other site 510831003449 Switch II region; other site 510831003450 G4 box; other site 510831003451 G5 box; other site 510831003452 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 510831003453 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 510831003454 potential frameshift: common BLAST hit: gi|118497748|ref|YP_898798.1| methyltransferase 510831003455 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 510831003456 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 510831003457 potential frameshift: common BLAST hit: gi|169656569|ref|YP_001428240.2| putative VacJ-like lipoprotein [Francisella tularensis subsp. 510831003458 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 510831003459 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 510831003460 hypothetical protein; Validated; Region: PRK01777 510831003461 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 510831003462 putative coenzyme Q binding site [chemical binding]; other site 510831003463 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 510831003464 SmpB-tmRNA interface; other site 510831003465 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 510831003466 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 510831003467 Ligand Binding Site [chemical binding]; other site 510831003468 potential frameshift: common BLAST hit: gi|134302170|ref|YP_001122139.1| major facilitator superfamily transporter 510831003469 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 510831003470 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 510831003471 generic binding surface II; other site 510831003472 generic binding surface I; other site 510831003473 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 510831003474 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 510831003475 metal binding site [ion binding]; metal-binding site 510831003476 dimer interface [polypeptide binding]; other site 510831003477 potential frameshift: common BLAST hit: gi|115314611|ref|YP_763334.1| possible transglutaminase 510831003478 potential frameshift: common BLAST hit: gi|134302174|ref|YP_001122143.1| Transglutaminase-like superfamily protein 510831003479 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 510831003480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 510831003481 metabolite-proton symporter; Region: 2A0106; TIGR00883 510831003482 glutamate racemase; Provisional; Region: PRK00865 510831003483 Nuclease-related domain; Region: NERD; pfam08378 510831003484 excinuclease ABC subunit B; Provisional; Region: PRK05298 510831003485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 510831003486 ATP binding site [chemical binding]; other site 510831003487 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 510831003488 nucleotide binding region [chemical binding]; other site 510831003489 ATP-binding site [chemical binding]; other site 510831003490 Ultra-violet resistance protein B; Region: UvrB; pfam12344 510831003491 UvrB/uvrC motif; Region: UVR; pfam02151 510831003492 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 510831003493 active site 510831003494 catalytic site [active] 510831003495 substrate binding site [chemical binding]; other site 510831003496 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 510831003497 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 510831003498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 510831003499 NAD(P) binding site [chemical binding]; other site 510831003500 active site 510831003501 Transcriptional regulator [Transcription]; Region: LysR; COG0583 510831003502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 510831003503 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 510831003504 putative effector binding pocket; other site 510831003505 dimerization interface [polypeptide binding]; other site 510831003506 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 510831003507 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 510831003508 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 510831003509 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 510831003510 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 510831003511 tetramer (dimer of dimers) interface [polypeptide binding]; other site 510831003512 active site 510831003513 dimer interface [polypeptide binding]; other site 510831003514 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 510831003515 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 510831003516 active site 510831003517 Zn binding site [ion binding]; other site 510831003518 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831003519 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831003520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831003521 Winged helix-turn helix; Region: HTH_29; pfam13551 510831003522 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 510831003523 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 510831003524 dimer interface [polypeptide binding]; other site 510831003525 active site 510831003526 metal binding site [ion binding]; metal-binding site 510831003527 glutathione binding site [chemical binding]; other site 510831003528 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 510831003529 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 510831003530 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 510831003531 active site 510831003532 motif I; other site 510831003533 motif II; other site 510831003534 Soluble P-type ATPase [General function prediction only]; Region: COG4087 510831003535 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 510831003536 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 510831003537 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 510831003538 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 510831003539 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 510831003540 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 510831003541 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 510831003542 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 510831003543 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 510831003544 BolA-like protein; Region: BolA; cl00386 510831003545 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 510831003546 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 510831003547 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 510831003548 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 510831003549 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 510831003550 Recombination protein O N terminal; Region: RecO_N; pfam11967 510831003551 Recombination protein O C terminal; Region: RecO_C; pfam02565 510831003552 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 510831003553 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 510831003554 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 510831003555 catalytic residue [active] 510831003556 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 510831003557 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 510831003558 homodimer interface [polypeptide binding]; other site 510831003559 oligonucleotide binding site [chemical binding]; other site 510831003560 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 510831003561 thymidylate synthase; Reviewed; Region: thyA; PRK01827 510831003562 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 510831003563 dimerization interface [polypeptide binding]; other site 510831003564 active site 510831003565 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 510831003566 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 510831003567 ligand binding site [chemical binding]; other site 510831003568 NAD binding site [chemical binding]; other site 510831003569 tetramer interface [polypeptide binding]; other site 510831003570 catalytic site [active] 510831003571 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 510831003572 L-serine binding site [chemical binding]; other site 510831003573 ACT domain interface; other site 510831003574 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 510831003575 Ligand Binding Site [chemical binding]; other site 510831003576 TilS substrate C-terminal domain; Region: TilS_C; smart00977 510831003577 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831003578 Winged helix-turn helix; Region: HTH_29; pfam13551 510831003579 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831003580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831003581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831003582 Major Facilitator Superfamily; Region: MFS_1; pfam07690 510831003583 putative substrate translocation pore; other site 510831003584 POT family; Region: PTR2; cl17359 510831003585 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 510831003586 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 510831003587 active site 510831003588 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 510831003589 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 510831003590 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 510831003591 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 510831003592 Ligand binding site; other site 510831003593 metal-binding site 510831003594 hypothetical protein; Provisional; Region: PRK05255 510831003595 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 510831003596 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 510831003597 dimer interface [polypeptide binding]; other site 510831003598 active site 510831003599 glycine-pyridoxal phosphate binding site [chemical binding]; other site 510831003600 folate binding site [chemical binding]; other site 510831003601 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 510831003602 FAD binding domain; Region: FAD_binding_4; pfam01565 510831003603 Berberine and berberine like; Region: BBE; pfam08031 510831003604 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 510831003605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 510831003606 TPR motif; other site 510831003607 binding surface 510831003608 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 510831003609 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 510831003610 RNA binding surface [nucleotide binding]; other site 510831003611 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 510831003612 active site 510831003613 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 510831003614 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 510831003615 Permease; Region: Permease; pfam02405 510831003616 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 510831003617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 510831003618 Walker A/P-loop; other site 510831003619 ATP binding site [chemical binding]; other site 510831003620 Q-loop/lid; other site 510831003621 ABC transporter signature motif; other site 510831003622 Walker B; other site 510831003623 D-loop; other site 510831003624 H-loop/switch region; other site 510831003625 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 510831003626 mce related protein; Region: MCE; pfam02470 510831003627 Protein of unknown function (DUF445); Region: DUF445; pfam04286 510831003628 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 510831003629 RNA methyltransferase, RsmE family; Region: TIGR00046 510831003630 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 510831003631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831003632 putative substrate translocation pore; other site 510831003633 POT family; Region: PTR2; cl17359 510831003634 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 510831003635 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 510831003636 acyl-activating enzyme (AAE) consensus motif; other site 510831003637 putative AMP binding site [chemical binding]; other site 510831003638 putative active site [active] 510831003639 putative CoA binding site [chemical binding]; other site 510831003640 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 510831003641 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 510831003642 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 510831003643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831003644 putative substrate translocation pore; other site 510831003645 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 510831003646 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 510831003647 HlyD family secretion protein; Region: HlyD_3; pfam13437 510831003648 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 510831003649 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 510831003650 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 510831003651 homodimer interface [polypeptide binding]; other site 510831003652 NAD binding pocket [chemical binding]; other site 510831003653 ATP binding pocket [chemical binding]; other site 510831003654 Mg binding site [ion binding]; other site 510831003655 active-site loop [active] 510831003656 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 510831003657 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 510831003658 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 510831003659 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831003660 Winged helix-turn helix; Region: HTH_29; pfam13551 510831003661 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831003662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831003663 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 510831003664 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831003665 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831003666 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831003667 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831003668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831003669 Winged helix-turn helix; Region: HTH_29; pfam13551 510831003670 Pirin-related protein [General function prediction only]; Region: COG1741 510831003671 Pirin; Region: Pirin; pfam02678 510831003672 Transcriptional regulator [Transcription]; Region: LysR; COG0583 510831003673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 510831003674 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 510831003675 putative effector binding pocket; other site 510831003676 dimerization interface [polypeptide binding]; other site 510831003677 chaperone protein DnaJ; Provisional; Region: PRK10767 510831003678 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 510831003679 HSP70 interaction site [polypeptide binding]; other site 510831003680 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 510831003681 substrate binding site [polypeptide binding]; other site 510831003682 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 510831003683 Zn binding sites [ion binding]; other site 510831003684 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 510831003685 dimer interface [polypeptide binding]; other site 510831003686 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 510831003687 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 510831003688 nucleotide binding site [chemical binding]; other site 510831003689 GrpE; Region: GrpE; pfam01025 510831003690 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 510831003691 dimer interface [polypeptide binding]; other site 510831003692 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 510831003693 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 510831003694 MltA specific insert domain; Region: MltA; smart00925 510831003695 3D domain; Region: 3D; pfam06725 510831003696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 510831003697 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 510831003698 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 510831003699 23S rRNA interface [nucleotide binding]; other site 510831003700 L3 interface [polypeptide binding]; other site 510831003701 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 510831003702 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 510831003703 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 510831003704 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 510831003705 Na binding site [ion binding]; other site 510831003706 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 510831003707 RNA/DNA hybrid binding site [nucleotide binding]; other site 510831003708 active site 510831003709 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 510831003710 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 510831003711 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 510831003712 active site 510831003713 phosphorylation site [posttranslational modification] 510831003714 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 510831003715 30S subunit binding site; other site 510831003716 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 510831003717 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 510831003718 trmE is a tRNA modification GTPase; Region: trmE; cd04164 510831003719 G1 box; other site 510831003720 GTP/Mg2+ binding site [chemical binding]; other site 510831003721 Switch I region; other site 510831003722 G2 box; other site 510831003723 Switch II region; other site 510831003724 G3 box; other site 510831003725 G4 box; other site 510831003726 G5 box; other site 510831003727 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 510831003728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 510831003729 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 510831003730 putative DNA binding site [nucleotide binding]; other site 510831003731 putative Zn2+ binding site [ion binding]; other site 510831003732 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 510831003733 dimerization interface [polypeptide binding]; other site 510831003734 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 510831003735 active site 510831003736 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 510831003737 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 510831003738 dimer interface [polypeptide binding]; other site 510831003739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 510831003740 catalytic residue [active] 510831003741 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 510831003742 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 510831003743 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 510831003744 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 510831003745 Intracellular growth locus C protein; Region: IglC; pfam11550 510831003746 Protein of unknown function (DUF877); Region: DUF877; pfam05943 510831003747 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 510831003748 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 510831003749 potential frameshift: common BLAST hit: gi|156502584|ref|YP_001428649.1| major facilitator superfamily 510831003750 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831003751 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831003752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831003753 Winged helix-turn helix; Region: HTH_29; pfam13551 510831003754 potential frameshift: common BLAST hit: gi|89256475|ref|YP_513837.1| Trehalase, pseuodgene 510831003755 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 510831003756 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 510831003757 intersubunit interface [polypeptide binding]; other site 510831003758 active site 510831003759 zinc binding site [ion binding]; other site 510831003760 Na+ binding site [ion binding]; other site 510831003761 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 510831003762 pyruvate kinase; Provisional; Region: PRK05826 510831003763 domain interfaces; other site 510831003764 active site 510831003765 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 510831003766 Phosphoglycerate kinase; Region: PGK; pfam00162 510831003767 substrate binding site [chemical binding]; other site 510831003768 hinge regions; other site 510831003769 ADP binding site [chemical binding]; other site 510831003770 catalytic site [active] 510831003771 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 510831003772 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 510831003773 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 510831003774 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 510831003775 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 510831003776 TPP-binding site [chemical binding]; other site 510831003777 dimer interface [polypeptide binding]; other site 510831003778 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 510831003779 PYR/PP interface [polypeptide binding]; other site 510831003780 dimer interface [polypeptide binding]; other site 510831003781 TPP binding site [chemical binding]; other site 510831003782 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 510831003783 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 510831003784 putative phosphate acyltransferase; Provisional; Region: PRK05331 510831003785 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 510831003786 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 510831003787 dimer interface [polypeptide binding]; other site 510831003788 active site 510831003789 CoA binding pocket [chemical binding]; other site 510831003790 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 510831003791 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 510831003792 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 510831003793 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 510831003794 NAD(P) binding site [chemical binding]; other site 510831003795 homotetramer interface [polypeptide binding]; other site 510831003796 homodimer interface [polypeptide binding]; other site 510831003797 active site 510831003798 acyl carrier protein; Provisional; Region: acpP; PRK00982 510831003799 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 510831003800 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 510831003801 dimer interface [polypeptide binding]; other site 510831003802 active site 510831003803 YCII-related domain; Region: YCII; cl00999 510831003804 Uncharacterized conserved protein [Function unknown]; Region: COG4121 510831003805 potential frameshift: common BLAST hit: gi|115314894|ref|YP_763617.1| possible MFS family major facilitator transporter 510831003806 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 510831003807 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 510831003808 active site 510831003809 dimerization interface [polypeptide binding]; other site 510831003810 16S rRNA methyltransferase B; Provisional; Region: PRK10901 510831003811 NusB family; Region: NusB; pfam01029 510831003812 putative RNA binding site [nucleotide binding]; other site 510831003813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 510831003814 S-adenosylmethionine binding site [chemical binding]; other site 510831003815 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 510831003816 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831003817 Winged helix-turn helix; Region: HTH_29; pfam13551 510831003818 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831003819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831003820 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 510831003821 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 510831003822 nucleotide binding pocket [chemical binding]; other site 510831003823 K-X-D-G motif; other site 510831003824 catalytic site [active] 510831003825 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 510831003826 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 510831003827 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 510831003828 Dimer interface [polypeptide binding]; other site 510831003829 BRCT sequence motif; other site 510831003830 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 510831003831 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 510831003832 active site 510831003833 oligomerization interface [polypeptide binding]; other site 510831003834 metal binding site [ion binding]; metal-binding site 510831003835 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 510831003836 pantoate--beta-alanine ligase; Region: panC; TIGR00018 510831003837 active site 510831003838 nucleotide binding site [chemical binding]; other site 510831003839 HIGH motif; other site 510831003840 KMSKS motif; other site 510831003841 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 510831003842 tetramerization interface [polypeptide binding]; other site 510831003843 active site 510831003844 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 510831003845 nucleotide binding site [chemical binding]; other site 510831003846 Type III pantothenate kinase; Region: Pan_kinase; cl17198 510831003847 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 510831003848 AAA domain; Region: AAA_30; pfam13604 510831003849 Family description; Region: UvrD_C_2; pfam13538 510831003850 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 510831003851 Family description; Region: UvrD_C_2; pfam13538 510831003852 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 510831003853 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 510831003854 Divergent AAA domain; Region: AAA_4; pfam04326 510831003855 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 510831003856 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 510831003857 putative DNA binding site [nucleotide binding]; other site 510831003858 putative Zn2+ binding site [ion binding]; other site 510831003859 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 510831003860 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 510831003861 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 510831003862 potential frameshift: common BLAST hit: gi|134301561|ref|YP_001121529.1| putative glutamate synthase 510831003863 EamA-like transporter family; Region: EamA; pfam00892 510831003864 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 510831003865 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 510831003866 non-specific DNA binding site [nucleotide binding]; other site 510831003867 salt bridge; other site 510831003868 sequence-specific DNA binding site [nucleotide binding]; other site 510831003869 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 510831003870 Catalytic site [active] 510831003871 FeoA domain; Region: FeoA; cl00838 510831003872 Sporulation related domain; Region: SPOR; pfam05036 510831003873 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 510831003874 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 510831003875 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 510831003876 active site 510831003877 Fe-S metabolism associated domain; Region: SufE; cl00951 510831003878 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 510831003879 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 510831003880 nucleic acid binding site [nucleotide binding]; other site 510831003881 prolyl-tRNA synthetase; Provisional; Region: PRK09194 510831003882 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 510831003883 dimer interface [polypeptide binding]; other site 510831003884 motif 1; other site 510831003885 active site 510831003886 motif 2; other site 510831003887 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 510831003888 putative deacylase active site [active] 510831003889 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 510831003890 active site 510831003891 motif 3; other site 510831003892 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 510831003893 anticodon binding site; other site 510831003894 methionine aminotransferase; Validated; Region: PRK09082 510831003895 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 510831003896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 510831003897 homodimer interface [polypeptide binding]; other site 510831003898 catalytic residue [active] 510831003899 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 510831003900 C-N hydrolase family amidase; Provisional; Region: PRK10438 510831003901 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 510831003902 putative active site [active] 510831003903 catalytic triad [active] 510831003904 dimer interface [polypeptide binding]; other site 510831003905 multimer interface [polypeptide binding]; other site 510831003906 transcription antitermination factor NusB; Region: nusB; TIGR01951 510831003907 putative RNA binding site [nucleotide binding]; other site 510831003908 hypothetical protein; Provisional; Region: PRK05170 510831003909 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 510831003910 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 510831003911 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 510831003912 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 510831003913 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 510831003914 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 510831003915 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 510831003916 active site residue [active] 510831003917 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 510831003918 active site residue [active] 510831003919 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 510831003920 putative DNA binding site [nucleotide binding]; other site 510831003921 putative Zn2+ binding site [ion binding]; other site 510831003922 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831003923 Winged helix-turn helix; Region: HTH_29; pfam13551 510831003924 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831003925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831003926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 510831003927 Coenzyme A binding pocket [chemical binding]; other site 510831003928 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 510831003929 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 510831003930 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 510831003931 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 510831003932 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 510831003933 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 510831003934 Ligand binding site; other site 510831003935 Putative Catalytic site; other site 510831003936 DXD motif; other site 510831003937 inner membrane transport permease; Provisional; Region: PRK15066 510831003938 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 510831003939 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 510831003940 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 510831003941 Walker A/P-loop; other site 510831003942 ATP binding site [chemical binding]; other site 510831003943 Q-loop/lid; other site 510831003944 ABC transporter signature motif; other site 510831003945 Walker B; other site 510831003946 D-loop; other site 510831003947 H-loop/switch region; other site 510831003948 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 510831003949 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831003950 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831003951 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 510831003952 active site 510831003953 potential frameshift: common BLAST hit: gi|118497983|ref|YP_899033.1| major facilitator superfamily (MFS) transport protein 510831003954 Ferritin-like domain; Region: Ferritin; pfam00210 510831003955 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 510831003956 dinuclear metal binding motif [ion binding]; other site 510831003957 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 510831003958 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 510831003959 dimer interface [polypeptide binding]; other site 510831003960 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 510831003961 recombination factor protein RarA; Provisional; Region: PRK14700 510831003962 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 510831003963 exopolyphosphatase; Region: exo_poly_only; TIGR03706 510831003964 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 510831003965 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 510831003966 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 510831003967 catalytic residues [active] 510831003968 transcription termination factor Rho; Provisional; Region: rho; PRK09376 510831003969 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 510831003970 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 510831003971 RNA binding site [nucleotide binding]; other site 510831003972 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 510831003973 multimer interface [polypeptide binding]; other site 510831003974 Walker A motif; other site 510831003975 ATP binding site [chemical binding]; other site 510831003976 Walker B motif; other site 510831003977 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 510831003978 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 510831003979 active site 510831003980 substrate binding site [chemical binding]; other site 510831003981 metal binding site [ion binding]; metal-binding site 510831003982 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 510831003983 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 510831003984 Substrate binding site; other site 510831003985 Cupin domain; Region: Cupin_2; cl17218 510831003986 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831003987 Winged helix-turn helix; Region: HTH_29; pfam13551 510831003988 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 510831003989 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 510831003990 NAD binding site [chemical binding]; other site 510831003991 substrate binding site [chemical binding]; other site 510831003992 homodimer interface [polypeptide binding]; other site 510831003993 active site 510831003994 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 510831003995 GIY-YIG motif/motif A; other site 510831003996 active site 510831003997 catalytic site [active] 510831003998 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 510831003999 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 510831004000 substrate binding site; other site 510831004001 tetramer interface; other site 510831004002 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 510831004003 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 510831004004 active site 510831004005 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 510831004006 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 510831004007 hypothetical protein; Provisional; Region: PRK07579 510831004008 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 510831004009 active site 510831004010 cosubstrate binding site; other site 510831004011 substrate binding site [chemical binding]; other site 510831004012 catalytic site [active] 510831004013 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 510831004014 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 510831004015 inhibitor-cofactor binding pocket; inhibition site 510831004016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 510831004017 catalytic residue [active] 510831004018 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 510831004019 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 510831004020 active site 510831004021 dimer interface [polypeptide binding]; other site 510831004022 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 510831004023 Ligand Binding Site [chemical binding]; other site 510831004024 Molecular Tunnel; other site 510831004025 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 510831004026 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 510831004027 putative ADP-binding pocket [chemical binding]; other site 510831004028 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 510831004029 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 510831004030 NAD binding site [chemical binding]; other site 510831004031 substrate binding site [chemical binding]; other site 510831004032 homodimer interface [polypeptide binding]; other site 510831004033 active site 510831004034 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 510831004035 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 510831004036 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 510831004037 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 510831004038 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 510831004039 putative ADP-binding pocket [chemical binding]; other site 510831004040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 510831004041 NADH(P)-binding; Region: NAD_binding_10; pfam13460 510831004042 NAD(P) binding site [chemical binding]; other site 510831004043 active site 510831004044 Bacterial sugar transferase; Region: Bac_transf; pfam02397 510831004045 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 510831004046 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 510831004047 NAD(P) binding site [chemical binding]; other site 510831004048 homodimer interface [polypeptide binding]; other site 510831004049 substrate binding site [chemical binding]; other site 510831004050 active site 510831004051 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 510831004052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831004053 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831004054 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 510831004055 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 510831004056 L-aspartate oxidase; Provisional; Region: PRK09077 510831004057 L-aspartate oxidase; Provisional; Region: PRK06175 510831004058 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 510831004059 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 510831004060 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 510831004061 dimerization interface [polypeptide binding]; other site 510831004062 active site 510831004063 quinolinate synthetase; Provisional; Region: PRK09375 510831004064 Guanylate kinase; Region: Guanylate_kin; pfam00625 510831004065 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 510831004066 catalytic site [active] 510831004067 G-X2-G-X-G-K; other site 510831004068 helicase 45; Provisional; Region: PTZ00424 510831004069 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 510831004070 ATP binding site [chemical binding]; other site 510831004071 Mg++ binding site [ion binding]; other site 510831004072 motif III; other site 510831004073 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 510831004074 nucleotide binding region [chemical binding]; other site 510831004075 ATP-binding site [chemical binding]; other site 510831004076 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 510831004077 putative RNA binding site [nucleotide binding]; other site 510831004078 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 510831004079 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 510831004080 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 510831004081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831004082 putative substrate translocation pore; other site 510831004083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831004084 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 510831004085 putative substrate translocation pore; other site 510831004086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831004087 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 510831004088 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 510831004089 dimer interface [polypeptide binding]; other site 510831004090 active site 510831004091 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 510831004092 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 510831004093 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 510831004094 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 510831004095 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 510831004096 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 510831004097 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 510831004098 Ligand binding site; other site 510831004099 oligomer interface; other site 510831004100 Uncharacterized conserved protein [Function unknown]; Region: COG2835 510831004101 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 510831004102 active site 510831004103 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831004104 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831004105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831004106 Winged helix-turn helix; Region: HTH_29; pfam13551 510831004107 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 510831004108 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 510831004109 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 510831004110 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 510831004111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 510831004112 NAD binding site [chemical binding]; other site 510831004113 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 510831004114 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 510831004115 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 510831004116 E3 interaction surface; other site 510831004117 lipoyl attachment site [posttranslational modification]; other site 510831004118 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 510831004119 E3 interaction surface; other site 510831004120 lipoyl attachment site [posttranslational modification]; other site 510831004121 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 510831004122 E3 interaction surface; other site 510831004123 lipoyl attachment site [posttranslational modification]; other site 510831004124 e3 binding domain; Region: E3_binding; pfam02817 510831004125 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 510831004126 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 510831004127 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 510831004128 dimer interface [polypeptide binding]; other site 510831004129 TPP-binding site [chemical binding]; other site 510831004130 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 510831004131 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 510831004132 dephospho-CoA kinase; Region: TIGR00152 510831004133 CoA-binding site [chemical binding]; other site 510831004134 ATP-binding [chemical binding]; other site 510831004135 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 510831004136 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 510831004137 active site 510831004138 HIGH motif; other site 510831004139 dimer interface [polypeptide binding]; other site 510831004140 KMSKS motif; other site 510831004141 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 510831004142 Zeta toxin; Region: Zeta_toxin; pfam06414 510831004143 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890 510831004144 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 510831004145 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 510831004146 putative active site [active] 510831004147 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 510831004148 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 510831004149 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 510831004150 MutS domain I; Region: MutS_I; pfam01624 510831004151 MutS domain III; Region: MutS_III; pfam05192 510831004152 MutS domain V; Region: MutS_V; pfam00488 510831004153 Walker A/P-loop; other site 510831004154 ATP binding site [chemical binding]; other site 510831004155 Q-loop/lid; other site 510831004156 ABC transporter signature motif; other site 510831004157 Walker B; other site 510831004158 D-loop; other site 510831004159 H-loop/switch region; other site 510831004160 preprotein translocase subunit SecB; Validated; Region: PRK05751 510831004161 SecA binding site; other site 510831004162 Preprotein binding site; other site 510831004163 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 510831004164 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 510831004165 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 510831004166 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 510831004167 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 510831004168 active site 510831004169 DNA binding site [nucleotide binding] 510831004170 Int/Topo IB signature motif; other site 510831004171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 510831004172 S-adenosylmethionine binding site [chemical binding]; other site 510831004173 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 510831004174 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 510831004175 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 510831004176 HD domain; Region: HD_4; pfam13328 510831004177 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 510831004178 synthetase active site [active] 510831004179 NTP binding site [chemical binding]; other site 510831004180 metal binding site [ion binding]; metal-binding site 510831004181 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 510831004182 Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; Region: PI3Ka; cl00271 510831004183 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 510831004184 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 510831004185 EamA-like transporter family; Region: EamA; pfam00892 510831004186 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 510831004187 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 510831004188 HSP70 interaction site [polypeptide binding]; other site 510831004189 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 510831004190 substrate binding site [polypeptide binding]; other site 510831004191 dimer interface [polypeptide binding]; other site 510831004192 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 510831004193 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 510831004194 potential frameshift: common BLAST hit: gi|118498095|ref|YP_899145.1| dihydrolipoamide dehydrogenase 510831004195 Uncharacterized conserved protein [Function unknown]; Region: COG0398 510831004196 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 510831004197 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 510831004198 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 510831004199 DNA binding site [nucleotide binding] 510831004200 active site 510831004201 Amino acid permease; Region: AA_permease_2; pfam13520 510831004202 potential frameshift: common BLAST hit: gi|89255705|ref|YP_513066.1| diaminopimelate decarboxylase 510831004203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 510831004204 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 510831004205 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831004206 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831004207 DEAD-like helicases superfamily; Region: DEXDc; smart00487 510831004208 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 510831004209 ATP binding site [chemical binding]; other site 510831004210 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 510831004211 putative Mg++ binding site [ion binding]; other site 510831004212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 510831004213 nucleotide binding region [chemical binding]; other site 510831004214 ATP-binding site [chemical binding]; other site 510831004215 Helicase associated domain (HA2); Region: HA2; pfam04408 510831004216 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 510831004217 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 510831004218 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 510831004219 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 510831004220 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 510831004221 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 510831004222 ArsC family; Region: ArsC; pfam03960 510831004223 catalytic residues [active] 510831004224 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 510831004225 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 510831004226 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 510831004227 acyl-activating enzyme (AAE) consensus motif; other site 510831004228 putative AMP binding site [chemical binding]; other site 510831004229 putative active site [active] 510831004230 putative CoA binding site [chemical binding]; other site 510831004231 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 510831004232 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 510831004233 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 510831004234 active site 510831004235 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 510831004236 Acyl CoA binding protein; Region: ACBP; pfam00887 510831004237 acyl-CoA binding pocket [chemical binding]; other site 510831004238 CoA binding site [chemical binding]; other site 510831004239 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 510831004240 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 510831004241 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 510831004242 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 510831004243 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 510831004244 substrate binding site [chemical binding]; other site 510831004245 oxyanion hole (OAH) forming residues; other site 510831004246 trimer interface [polypeptide binding]; other site 510831004247 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 510831004248 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 510831004249 dimer interface [polypeptide binding]; other site 510831004250 active site 510831004251 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 510831004252 CoenzymeA binding site [chemical binding]; other site 510831004253 subunit interaction site [polypeptide binding]; other site 510831004254 PHB binding site; other site 510831004255 potential frameshift: common BLAST hit: gi|169656545|ref|YP_001428047.2| major facilitator superfamily (MFS) transport protein [Francisella 510831004256 Protein of unknown function (DUF465); Region: DUF465; cl01070 510831004257 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 510831004258 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 510831004259 active site 510831004260 potential frameshift: common BLAST hit: gi|118498016|ref|YP_899066.1| ornithine cyclodeaminase 510831004261 potential frameshift: common BLAST hit: gi|118498016|ref|YP_899066.1| ornithine cyclodeaminase 510831004262 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 510831004263 Amidinotransferase; Region: Amidinotransf; pfam02274 510831004264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 510831004265 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 510831004266 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 510831004267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 510831004268 active site 510831004269 phosphorylation site [posttranslational modification] 510831004270 intermolecular recognition site; other site 510831004271 dimerization interface [polypeptide binding]; other site 510831004272 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 510831004273 DNA binding site [nucleotide binding] 510831004274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 510831004275 dimer interface [polypeptide binding]; other site 510831004276 phosphorylation site [posttranslational modification] 510831004277 potential frameshift: common BLAST hit: gi|134301471|ref|YP_001121439.1| putative flavin containing amine oxidoreductase 510831004278 potential frameshift: common BLAST hit: gi|145590151|ref|YP_001156748.1| protein of unknown function DUF1365 510831004279 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 510831004280 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831004281 Winged helix-turn helix; Region: HTH_29; pfam13551 510831004282 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831004283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831004284 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 510831004285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 510831004286 S-adenosylmethionine binding site [chemical binding]; other site 510831004287 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 510831004288 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 510831004289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 510831004290 NAD(P) binding site [chemical binding]; other site 510831004291 active site 510831004292 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 510831004293 Fatty acid desaturase; Region: FA_desaturase; pfam00487 510831004294 Di-iron ligands [ion binding]; other site 510831004295 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 510831004296 ribonuclease R; Region: RNase_R; TIGR02063 510831004297 RNB domain; Region: RNB; pfam00773 510831004298 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 510831004299 RNA binding site [nucleotide binding]; other site 510831004300 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 510831004301 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 510831004302 RNA binding site [nucleotide binding]; other site 510831004303 active site 510831004304 ribonuclease III; Reviewed; Region: rnc; PRK00102 510831004305 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 510831004306 dimerization interface [polypeptide binding]; other site 510831004307 active site 510831004308 metal binding site [ion binding]; metal-binding site 510831004309 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 510831004310 dsRNA binding site [nucleotide binding]; other site 510831004311 signal peptidase I; Provisional; Region: PRK10861 510831004312 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 510831004313 Catalytic site [active] 510831004314 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 510831004315 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 510831004316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 510831004317 active site 510831004318 phosphorylation site [posttranslational modification] 510831004319 intermolecular recognition site; other site 510831004320 dimerization interface [polypeptide binding]; other site 510831004321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 510831004322 DNA binding site [nucleotide binding] 510831004323 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 510831004324 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 510831004325 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 510831004326 active site 510831004327 dimerization interface [polypeptide binding]; other site 510831004328 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 510831004329 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 510831004330 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 510831004331 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 510831004332 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 510831004333 substrate binding pocket [chemical binding]; other site 510831004334 chain length determination region; other site 510831004335 substrate-Mg2+ binding site; other site 510831004336 catalytic residues [active] 510831004337 aspartate-rich region 1; other site 510831004338 active site lid residues [active] 510831004339 aspartate-rich region 2; other site 510831004340 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 510831004341 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 510831004342 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 510831004343 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 510831004344 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 510831004345 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 510831004346 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 510831004347 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 510831004348 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 510831004349 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 510831004350 active site 510831004351 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 510831004352 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 510831004353 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 510831004354 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 510831004355 trimer interface [polypeptide binding]; other site 510831004356 active site 510831004357 UDP-GlcNAc binding site [chemical binding]; other site 510831004358 lipid binding site [chemical binding]; lipid-binding site 510831004359 periplasmic chaperone; Provisional; Region: PRK10780 510831004360 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 510831004361 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 510831004362 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 510831004363 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 510831004364 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 510831004365 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 510831004366 Surface antigen; Region: Bac_surface_Ag; pfam01103 510831004367 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 510831004368 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 510831004369 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 510831004370 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 510831004371 DNA gyrase subunit A; Validated; Region: PRK05560 510831004372 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 510831004373 CAP-like domain; other site 510831004374 active site 510831004375 primary dimer interface [polypeptide binding]; other site 510831004376 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 510831004377 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 510831004378 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 510831004379 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 510831004380 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 510831004381 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 510831004382 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 510831004383 aromatic chitin/cellulose binding site residues [chemical binding]; other site 510831004384 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 510831004385 ligand binding site [chemical binding]; other site 510831004386 active site 510831004387 UGI interface [polypeptide binding]; other site 510831004388 catalytic site [active] 510831004389 Restriction endonuclease [Defense mechanisms]; Region: COG3587 510831004390 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 510831004391 ATP binding site [chemical binding]; other site 510831004392 putative Mg++ binding site [ion binding]; other site 510831004393 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 510831004394 GIY-YIG motif/motif A; other site 510831004395 putative active site [active] 510831004396 putative metal binding site [ion binding]; other site 510831004397 DNA methylase; Region: N6_N4_Mtase; cl17433 510831004398 potential frameshift: common BLAST hit: gi|150398910|ref|YP_001322677.1| Site-specific DNA-methyltransferase (adenine-specific) 510831004399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 510831004400 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831004401 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831004402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831004403 Winged helix-turn helix; Region: HTH_29; pfam13551 510831004404 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 510831004405 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 510831004406 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 510831004407 Methyltransferase domain; Region: Methyltransf_11; pfam08241 510831004408 VacJ like lipoprotein; Region: VacJ; cl01073 510831004409 potential frameshift: common BLAST hit: gi|134301414|ref|YP_001121382.1| glycosyl hydrolase, family 18 protein 510831004410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 510831004411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 510831004412 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 510831004413 dimerization interface [polypeptide binding]; other site 510831004414 potential frameshift: common BLAST hit: gi|156503091|ref|YP_001429156.1| aminotransferase ubiquitination site family 510831004415 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831004416 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831004417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831004418 Winged helix-turn helix; Region: HTH_29; pfam13551 510831004419 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 510831004420 Fumarase C-terminus; Region: Fumerase_C; pfam05683 510831004421 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 510831004422 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 510831004423 ssDNA binding site; other site 510831004424 generic binding surface II; other site 510831004425 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 510831004426 ATP binding site [chemical binding]; other site 510831004427 putative Mg++ binding site [ion binding]; other site 510831004428 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 510831004429 nucleotide binding region [chemical binding]; other site 510831004430 ATP-binding site [chemical binding]; other site 510831004431 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 510831004432 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 510831004433 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 510831004434 septum formation inhibitor; Reviewed; Region: minC; PRK04804 510831004435 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 510831004436 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 510831004437 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 510831004438 Switch I; other site 510831004439 Switch II; other site 510831004440 cell division topological specificity factor MinE; Provisional; Region: PRK13990 510831004441 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 510831004442 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 510831004443 Walker A/P-loop; other site 510831004444 ATP binding site [chemical binding]; other site 510831004445 Q-loop/lid; other site 510831004446 ABC transporter signature motif; other site 510831004447 Walker B; other site 510831004448 D-loop; other site 510831004449 H-loop/switch region; other site 510831004450 Permease; Region: Permease; pfam02405 510831004451 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 510831004452 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 510831004453 mce related protein; Region: MCE; pfam02470 510831004454 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 510831004455 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 510831004456 anti sigma factor interaction site; other site 510831004457 regulatory phosphorylation site [posttranslational modification]; other site 510831004458 BolA-like protein; Region: BolA; cl00386 510831004459 potential frameshift: common BLAST hit: gi|110671244|ref|YP_667801.1| Transposase 510831004460 glycerol kinase; Region: PLN02295 510831004461 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 510831004462 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 510831004463 active site 510831004464 HIGH motif; other site 510831004465 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 510831004466 KMSKS motif; other site 510831004467 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 510831004468 tRNA binding surface [nucleotide binding]; other site 510831004469 anticodon binding site; other site 510831004470 HemK family putative methylases; Region: hemK_fam; TIGR00536 510831004471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 510831004472 S-adenosylmethionine binding site [chemical binding]; other site 510831004473 potential frameshift: common BLAST hit: gi|118496922|ref|YP_897972.1| drug:H+ antiporter-1 (DHA1) family protein 510831004474 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 510831004475 Coenzyme A binding pocket [chemical binding]; other site 510831004476 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831004477 Winged helix-turn helix; Region: HTH_29; pfam13551 510831004478 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831004479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831004480 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 510831004481 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 510831004482 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 510831004483 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 510831004484 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 510831004485 Domain of unknown function DUF21; Region: DUF21; pfam01595 510831004486 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 510831004487 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 510831004488 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 510831004489 DXD motif; other site 510831004490 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 510831004491 Na binding site [ion binding]; other site 510831004492 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 510831004493 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 510831004494 putative active site [active] 510831004495 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 510831004496 lysine transporter; Provisional; Region: PRK10836 510831004497 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 510831004498 active site 510831004499 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 510831004500 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 510831004501 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 510831004502 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 510831004503 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 510831004504 Cation transport protein; Region: TrkH; cl17365 510831004505 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 510831004506 ProQ/FINO family; Region: ProQ; pfam04352 510831004507 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 510831004508 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 510831004509 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 510831004510 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 510831004511 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 510831004512 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831004513 Winged helix-turn helix; Region: HTH_29; pfam13551 510831004514 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831004515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831004516 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 510831004517 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 510831004518 substrate binding [chemical binding]; other site 510831004519 active site 510831004520 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 510831004521 Major Facilitator Superfamily; Region: MFS_1; pfam07690 510831004522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831004523 putative substrate translocation pore; other site 510831004524 potential frameshift: common BLAST hit: gi|134302764|ref|YP_001122732.1| D-tyrosyl-tRNA(Tyr) deacylase 510831004525 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 510831004526 phosphate binding site [ion binding]; other site 510831004527 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 510831004528 active site 510831004529 dimer interface [polypeptide binding]; other site 510831004530 potential frameshift: common BLAST hit: gi|115314014|ref|YP_762737.1| probable transglutaminase 510831004531 Chorismate mutase type II; Region: CM_2; smart00830 510831004532 SOUL heme-binding protein; Region: SOUL; pfam04832 510831004533 Transcriptional regulator [Transcription]; Region: LysR; COG0583 510831004534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 510831004535 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 510831004536 dimerization interface [polypeptide binding]; other site 510831004537 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 510831004538 HlyD family secretion protein; Region: HlyD; pfam00529 510831004539 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 510831004540 HlyD family secretion protein; Region: HlyD_3; pfam13437 510831004541 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 510831004542 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 510831004543 dihydroorotase; Reviewed; Region: PRK09236 510831004544 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 510831004545 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 510831004546 active site 510831004547 thiopurine S-methyltransferase; Reviewed; Region: PRK13256 510831004548 potential frameshift: common BLAST hit: gi|118496637|ref|YP_897687.1| histidine acid phosphatase 510831004549 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 510831004550 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 510831004551 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 510831004552 catalytic site [active] 510831004553 subunit interface [polypeptide binding]; other site 510831004554 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 510831004555 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 510831004556 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 510831004557 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 510831004558 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 510831004559 ATP-grasp domain; Region: ATP-grasp_4; cl17255 510831004560 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 510831004561 substrate binding site [chemical binding]; other site 510831004562 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 510831004563 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 510831004564 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 510831004565 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 510831004566 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 510831004567 NAD binding site [chemical binding]; other site 510831004568 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 510831004569 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 510831004570 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 510831004571 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831004572 Winged helix-turn helix; Region: HTH_29; pfam13551 510831004573 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831004574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831004575 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 510831004576 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 510831004577 catalytic motif [active] 510831004578 Zn binding site [ion binding]; other site 510831004579 RibD C-terminal domain; Region: RibD_C; pfam01872 510831004580 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 510831004581 Lumazine binding domain; Region: Lum_binding; pfam00677 510831004582 Lumazine binding domain; Region: Lum_binding; pfam00677 510831004583 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 510831004584 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 510831004585 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 510831004586 dimerization interface [polypeptide binding]; other site 510831004587 active site 510831004588 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 510831004589 homopentamer interface [polypeptide binding]; other site 510831004590 active site 510831004591 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 510831004592 active site 510831004593 catalytic residues [active] 510831004594 metal binding site [ion binding]; metal-binding site 510831004595 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 510831004596 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 510831004597 GTP-binding protein LepA; Provisional; Region: PRK05433 510831004598 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 510831004599 G1 box; other site 510831004600 putative GEF interaction site [polypeptide binding]; other site 510831004601 GTP/Mg2+ binding site [chemical binding]; other site 510831004602 Switch I region; other site 510831004603 G2 box; other site 510831004604 G3 box; other site 510831004605 Switch II region; other site 510831004606 G4 box; other site 510831004607 G5 box; other site 510831004608 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 510831004609 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 510831004610 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 510831004611 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 510831004612 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 510831004613 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 510831004614 dimer interface [polypeptide binding]; other site 510831004615 active site 510831004616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831004617 putative substrate translocation pore; other site 510831004618 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 510831004619 Transcriptional regulator [Transcription]; Region: LysR; COG0583 510831004620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 510831004621 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 510831004622 putative effector binding pocket; other site 510831004623 dimerization interface [polypeptide binding]; other site 510831004624 potential frameshift: common BLAST hit: gi|134302728|ref|YP_001122696.1| Hypothetical membrane protein 510831004625 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 510831004626 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 510831004627 catalytic residue [active] 510831004628 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 510831004629 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 510831004630 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 510831004631 aromatic amino acid transport protein; Region: araaP; TIGR00837 510831004632 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 510831004633 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 510831004634 putative FMN binding site [chemical binding]; other site 510831004635 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831004636 Winged helix-turn helix; Region: HTH_29; pfam13551 510831004637 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831004638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831004639 hypothetical protein; Validated; Region: PRK02101 510831004640 Predicted membrane protein [Function unknown]; Region: COG4125 510831004641 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 510831004642 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 510831004643 oligomerisation interface [polypeptide binding]; other site 510831004644 mobile loop; other site 510831004645 roof hairpin; other site 510831004646 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 510831004647 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 510831004648 ring oligomerisation interface [polypeptide binding]; other site 510831004649 ATP/Mg binding site [chemical binding]; other site 510831004650 stacking interactions; other site 510831004651 hinge regions; other site 510831004652 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831004653 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831004654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831004655 Winged helix-turn helix; Region: HTH_29; pfam13551 510831004656 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 510831004657 NAD binding site [chemical binding]; other site 510831004658 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 510831004659 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 510831004660 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 510831004661 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 510831004662 active site 510831004663 HIGH motif; other site 510831004664 KMSKS motif; other site 510831004665 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 510831004666 tRNA binding surface [nucleotide binding]; other site 510831004667 anticodon binding site; other site 510831004668 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 510831004669 dimer interface [polypeptide binding]; other site 510831004670 putative tRNA-binding site [nucleotide binding]; other site 510831004671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831004672 D-galactonate transporter; Region: 2A0114; TIGR00893 510831004673 putative substrate translocation pore; other site 510831004674 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 510831004675 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 510831004676 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 510831004677 Intracellular septation protein A; Region: IspA; pfam04279 510831004678 Glucokinase; Region: Glucokinase; pfam02685 510831004679 glucokinase, proteobacterial type; Region: glk; TIGR00749 510831004680 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 510831004681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 510831004682 S-adenosylmethionine binding site [chemical binding]; other site 510831004683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 510831004684 ABC1 family; Region: ABC1; cl17513 510831004685 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 510831004686 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 510831004687 nucleotide binding site/active site [active] 510831004688 HIT family signature motif; other site 510831004689 catalytic residue [active] 510831004690 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 510831004691 active site 510831004692 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 510831004693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 510831004694 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 510831004695 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 510831004696 FAD binding domain; Region: FAD_binding_4; pfam01565 510831004697 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 510831004698 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 510831004699 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 510831004700 putative active site [active] 510831004701 GTP-binding protein Der; Reviewed; Region: PRK00093 510831004702 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 510831004703 G1 box; other site 510831004704 GTP/Mg2+ binding site [chemical binding]; other site 510831004705 Switch I region; other site 510831004706 G2 box; other site 510831004707 Switch II region; other site 510831004708 G3 box; other site 510831004709 G4 box; other site 510831004710 G5 box; other site 510831004711 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 510831004712 G1 box; other site 510831004713 GTP/Mg2+ binding site [chemical binding]; other site 510831004714 Switch I region; other site 510831004715 G2 box; other site 510831004716 G3 box; other site 510831004717 Switch II region; other site 510831004718 G4 box; other site 510831004719 G5 box; other site 510831004720 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831004721 Winged helix-turn helix; Region: HTH_29; pfam13551 510831004722 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 510831004723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 510831004724 Walker A motif; other site 510831004725 ATP binding site [chemical binding]; other site 510831004726 Walker B motif; other site 510831004727 arginine finger; other site 510831004728 Peptidase family M41; Region: Peptidase_M41; pfam01434 510831004729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831004730 putative transporter; Provisional; Region: PRK10504 510831004731 putative substrate translocation pore; other site 510831004732 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 510831004733 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 510831004734 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 510831004735 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 510831004736 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 510831004737 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 510831004738 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 510831004739 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 510831004740 Type II transport protein GspH; Region: GspH; pfam12019 510831004741 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 510831004742 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 510831004743 active site 510831004744 dimer interface [polypeptide binding]; other site 510831004745 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 510831004746 dimer interface [polypeptide binding]; other site 510831004747 active site 510831004748 Thiamine pyrophosphokinase; Region: TPK; cd07995 510831004749 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 510831004750 active site 510831004751 dimerization interface [polypeptide binding]; other site 510831004752 thiamine binding site [chemical binding]; other site 510831004753 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 510831004754 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 510831004755 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 510831004756 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 510831004757 active site 510831004758 multifunctional aminopeptidase A; Provisional; Region: PRK00913 510831004759 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 510831004760 interface (dimer of trimers) [polypeptide binding]; other site 510831004761 Substrate-binding/catalytic site; other site 510831004762 Zn-binding sites [ion binding]; other site 510831004763 Predicted permeases [General function prediction only]; Region: COG0795 510831004764 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 510831004765 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 510831004766 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 510831004767 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 510831004768 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 510831004769 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 510831004770 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 510831004771 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 510831004772 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 510831004773 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 510831004774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 510831004775 Predicted membrane protein [Function unknown]; Region: COG2860 510831004776 UPF0126 domain; Region: UPF0126; pfam03458 510831004777 UPF0126 domain; Region: UPF0126; pfam03458 510831004778 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 510831004779 active site 510831004780 dinuclear metal binding site [ion binding]; other site 510831004781 dimerization interface [polypeptide binding]; other site 510831004782 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 510831004783 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 510831004784 active site 510831004785 catalytic motif [active] 510831004786 Zn binding site [ion binding]; other site 510831004787 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 510831004788 FAD binding domain; Region: FAD_binding_4; pfam01565 510831004789 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 510831004790 phosphoglyceromutase; Provisional; Region: PRK05434 510831004791 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 510831004792 seryl-tRNA synthetase; Provisional; Region: PRK05431 510831004793 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 510831004794 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 510831004795 dimer interface [polypeptide binding]; other site 510831004796 active site 510831004797 motif 1; other site 510831004798 motif 2; other site 510831004799 motif 3; other site 510831004800 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 510831004801 ROK family; Region: ROK; pfam00480 510831004802 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 510831004803 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 510831004804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 510831004805 Walker A/P-loop; other site 510831004806 ATP binding site [chemical binding]; other site 510831004807 Q-loop/lid; other site 510831004808 ABC transporter signature motif; other site 510831004809 Walker B; other site 510831004810 D-loop; other site 510831004811 H-loop/switch region; other site 510831004812 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 510831004813 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 510831004814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 510831004815 Walker A/P-loop; other site 510831004816 ATP binding site [chemical binding]; other site 510831004817 Q-loop/lid; other site 510831004818 ABC transporter signature motif; other site 510831004819 Walker B; other site 510831004820 D-loop; other site 510831004821 H-loop/switch region; other site 510831004822 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 510831004823 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 510831004824 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 510831004825 homotrimer interaction site [polypeptide binding]; other site 510831004826 putative active site [active] 510831004827 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 510831004828 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 510831004829 Sulfate transporter family; Region: Sulfate_transp; pfam00916 510831004830 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 510831004831 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 510831004832 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 510831004833 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 510831004834 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 510831004835 Peptidase family M50; Region: Peptidase_M50; pfam02163 510831004836 active site 510831004837 putative substrate binding region [chemical binding]; other site 510831004838 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 510831004839 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 510831004840 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 510831004841 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 510831004842 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 510831004843 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 510831004844 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 510831004845 Intracellular growth locus C protein; Region: IglC; pfam11550 510831004846 Protein of unknown function (DUF877); Region: DUF877; pfam05943 510831004847 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 510831004848 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 510831004849 potential frameshift: common BLAST hit: gi|156502584|ref|YP_001428649.1| major facilitator superfamily 510831004850 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831004851 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831004852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831004853 Winged helix-turn helix; Region: HTH_29; pfam13551 510831004854 potential frameshift: common BLAST hit: gi|158320884|ref|YP_001513391.1| DNA-cytosine methyltransferase 510831004855 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 510831004856 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 510831004857 dimerization interface [polypeptide binding]; other site 510831004858 ATP binding site [chemical binding]; other site 510831004859 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 510831004860 dimerization interface [polypeptide binding]; other site 510831004861 ATP binding site [chemical binding]; other site 510831004862 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 510831004863 putative active site [active] 510831004864 catalytic triad [active] 510831004865 amidophosphoribosyltransferase; Provisional; Region: PRK09246 510831004866 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 510831004867 active site 510831004868 tetramer interface [polypeptide binding]; other site 510831004869 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 510831004870 active site 510831004871 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 510831004872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 510831004873 catalytic residue [active] 510831004874 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 510831004875 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 510831004876 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 510831004877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 510831004878 putative protease; Provisional; Region: PRK15452 510831004879 Peptidase family U32; Region: Peptidase_U32; pfam01136 510831004880 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 510831004881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831004882 putative substrate translocation pore; other site 510831004883 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 510831004884 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 510831004885 potential frameshift: common BLAST hit: gi|118498269|ref|YP_899319.1| ATP-binding cassette (ABC) superfamily protein 510831004886 potential frameshift: common BLAST hit: gi|118498269|ref|YP_899319.1| ATP-binding cassette (ABC) superfamily protein 510831004887 Amino acid permease; Region: AA_permease_2; pfam13520 510831004888 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 510831004889 GTP1/OBG; Region: GTP1_OBG; pfam01018 510831004890 Obg GTPase; Region: Obg; cd01898 510831004891 G1 box; other site 510831004892 GTP/Mg2+ binding site [chemical binding]; other site 510831004893 Switch I region; other site 510831004894 G2 box; other site 510831004895 G3 box; other site 510831004896 Switch II region; other site 510831004897 G4 box; other site 510831004898 G5 box; other site 510831004899 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 510831004900 aromatic amino acid transport protein; Region: araaP; TIGR00837 510831004901 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 510831004902 DNA binding site [nucleotide binding] 510831004903 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 510831004904 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 510831004905 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 510831004906 Ligand Binding Site [chemical binding]; other site 510831004907 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 510831004908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 510831004909 dimer interface [polypeptide binding]; other site 510831004910 phosphorylation site [posttranslational modification] 510831004911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 510831004912 ATP binding site [chemical binding]; other site 510831004913 Mg2+ binding site [ion binding]; other site 510831004914 G-X-G motif; other site 510831004915 K+-transporting ATPase, c chain; Region: KdpC; cl00944 510831004916 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 510831004917 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 510831004918 Soluble P-type ATPase [General function prediction only]; Region: COG4087 510831004919 potential frameshift: common BLAST hit: gi|134301211|ref|YP_001121179.1| K+-transporting ATPase, A subunit 510831004920 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 510831004921 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831004922 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831004923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831004924 Winged helix-turn helix; Region: HTH_29; pfam13551 510831004925 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 510831004926 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 510831004927 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 510831004928 dimer interface [polypeptide binding]; other site 510831004929 PYR/PP interface [polypeptide binding]; other site 510831004930 TPP binding site [chemical binding]; other site 510831004931 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 510831004932 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 510831004933 TPP-binding site [chemical binding]; other site 510831004934 dimer interface [polypeptide binding]; other site 510831004935 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 510831004936 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 510831004937 tandem repeat interface [polypeptide binding]; other site 510831004938 oligomer interface [polypeptide binding]; other site 510831004939 active site residues [active] 510831004940 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 510831004941 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 510831004942 preprotein translocase subunit SecB; Provisional; Region: PRK13031 510831004943 SecA binding site; other site 510831004944 Preprotein binding site; other site 510831004945 recombinase A; Provisional; Region: recA; PRK09354 510831004946 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 510831004947 hexamer interface [polypeptide binding]; other site 510831004948 Walker A motif; other site 510831004949 ATP binding site [chemical binding]; other site 510831004950 Walker B motif; other site 510831004951 recombination regulator RecX; Reviewed; Region: recX; PRK00117 510831004952 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 510831004953 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 510831004954 dimer interface [polypeptide binding]; other site 510831004955 ssDNA binding site [nucleotide binding]; other site 510831004956 tetramer (dimer of dimers) interface [polypeptide binding]; other site 510831004957 propionate/acetate kinase; Provisional; Region: PRK12379 510831004958 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 510831004959 phosphate acetyltransferase; Reviewed; Region: PRK05632 510831004960 DRTGG domain; Region: DRTGG; pfam07085 510831004961 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 510831004962 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 510831004963 NAD(P) binding site [chemical binding]; other site 510831004964 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831004965 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831004966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831004967 Winged helix-turn helix; Region: HTH_29; pfam13551 510831004968 potential frameshift: common BLAST hit: gi|118498310|ref|YP_899360.1| metabolite:H+ symporter (MHS) family protein 510831004969 potential frameshift: common BLAST hit: gi|118498310|ref|YP_899360.1| metabolite:H+ symporter (MHS) family protein 510831004970 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 510831004971 potential frameshift: common BLAST hit: gi|134301190|ref|YP_001121158.1| Rieske (2Fe-2S) domain protein 510831004972 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854 510831004973 hypothetical protein; Provisional; Region: PRK05421 510831004974 putative catalytic site [active] 510831004975 putative metal binding site [ion binding]; other site 510831004976 putative phosphate binding site [ion binding]; other site 510831004977 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 510831004978 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 510831004979 putative acyl-acceptor binding pocket; other site 510831004980 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 510831004981 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 510831004982 putative acyl-acceptor binding pocket; other site 510831004983 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 510831004984 4Fe-4S binding domain; Region: Fer4; cl02805 510831004985 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 510831004986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 510831004987 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 510831004988 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 510831004989 ATP-grasp domain; Region: ATP-grasp; pfam02222 510831004990 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 510831004991 active site 510831004992 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 510831004993 Clp amino terminal domain; Region: Clp_N; pfam02861 510831004994 Clp amino terminal domain; Region: Clp_N; pfam02861 510831004995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 510831004996 Walker A motif; other site 510831004997 ATP binding site [chemical binding]; other site 510831004998 Walker B motif; other site 510831004999 arginine finger; other site 510831005000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 510831005001 Walker A motif; other site 510831005002 ATP binding site [chemical binding]; other site 510831005003 Walker B motif; other site 510831005004 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 510831005005 potential frameshift: common BLAST hit: gi|118498298|ref|YP_899348.1| nicotinamide ribonucleoside (NR) uptake permease (PnuC) family 510831005006 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 510831005007 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 510831005008 substrate binding site [chemical binding]; other site 510831005009 active site 510831005010 catalytic residues [active] 510831005011 heterodimer interface [polypeptide binding]; other site 510831005012 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 510831005013 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 510831005014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 510831005015 catalytic residue [active] 510831005016 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 510831005017 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 510831005018 Cl- selectivity filter; other site 510831005019 Cl- binding residues [ion binding]; other site 510831005020 pore gating glutamate residue; other site 510831005021 dimer interface [polypeptide binding]; other site 510831005022 H+/Cl- coupling transport residue; other site 510831005023 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 510831005024 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 510831005025 active site 510831005026 Zn binding site [ion binding]; other site 510831005027 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 510831005028 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 510831005029 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 510831005030 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 510831005031 potential frameshift: common BLAST hit: gi|255961469|ref|YP_003097807.1| transposase 510831005032 Winged helix-turn helix; Region: HTH_29; pfam13551 510831005033 DDE superfamily endonuclease; Region: DDE_3; pfam13358 510831005034 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 510831005035 Methyltransferase domain; Region: Methyltransf_31; pfam13847 510831005036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 510831005037 S-adenosylmethionine binding site [chemical binding]; other site 510831005038 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 510831005039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 510831005040 Walker A/P-loop; other site 510831005041 ATP binding site [chemical binding]; other site 510831005042 Q-loop/lid; other site 510831005043 ABC transporter signature motif; other site 510831005044 Walker B; other site 510831005045 D-loop; other site 510831005046 H-loop/switch region; other site 510831005047 ABC transporter; Region: ABC_tran_2; pfam12848 510831005048 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 510831005049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 510831005050 metabolite-proton symporter; Region: 2A0106; TIGR00883 510831005051 putative substrate translocation pore; other site 510831005052 LysE type translocator; Region: LysE; cl00565 510831005053 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 510831005054 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 510831005055 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 510831005056 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 510831005057 aminopeptidase N; Provisional; Region: pepN; PRK14015 510831005058 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 510831005059 active site 510831005060 Zn binding site [ion binding]; other site 510831005061 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 510831005062 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 510831005063 putative dimer interface [polypeptide binding]; other site 510831005064 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 510831005065 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 510831005066 active site 510831005067 ribulose/triose binding site [chemical binding]; other site 510831005068 phosphate binding site [ion binding]; other site 510831005069 substrate (anthranilate) binding pocket [chemical binding]; other site 510831005070 product (indole) binding pocket [chemical binding]; other site 510831005071 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 510831005072 active site 510831005073 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 510831005074 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 510831005075 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 510831005076 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 510831005077 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 510831005078 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 510831005079 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 510831005080 Glutamine amidotransferase class-I; Region: GATase; pfam00117 510831005081 glutamine binding [chemical binding]; other site 510831005082 catalytic triad [active] 510831005083 anthranilate synthase component I; Provisional; Region: PRK13564 510831005084 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 510831005085 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 510831005086 Trp repressor protein; Region: Trp_repressor; cl17266 510831005087 ribonuclease G; Provisional; Region: PRK11712 510831005088 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 510831005089 homodimer interface [polypeptide binding]; other site 510831005090 oligonucleotide binding site [chemical binding]; other site