-- dump date 20140619_095532 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_169084.1 56707188 3191523 1..1521 1 NC_006570.2 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosome replication initiator DnaA 1521 dnaA 3191523 dnaA Francisella tularensis subsp. tularensis SCHU S4 chromosome replication initiator DnaA YP_169084.1 1 D 177416 CDS YP_169085.1 56707189 3191533 1558..2661 1 NC_006570.2 Similar to DP3B_ECOLI (P00583) DNA polymerase III, beta chain from E. coli (366 aa). FASTA opt: 826 Z-score: 955.1 E(): 2.6e-45 Smith-Waterman score: 826; 35.230 identity in 369 aa overlap; DNA polymerase III subunit beta 2661 dnaN 3191533 dnaN Francisella tularensis subsp. tularensis SCHU S4 DNA polymerase III subunit beta YP_169085.1 1558 D 177416 CDS YP_169086.1 56707190 3192121 complement(join(3204..3662,3662..3988)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 3988 isftu1 3192121 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169086.1 3204 R 177416 CDS YP_169087.1 56707191 3192082 4661..5869 1 NC_006570.2 Similar to Q9ZE69 Proline/betaine transporter (PROP1) from Rickettsia prowazekii (418 aa). FASTA: opt: 605 Z-score: 665.8 E(): 3.4e-29 Smith-Waterman score: 605; 28.293 identity in 410 aa overlap ORF ftt0006; MFS superfamily proline/ betaine transporter 5869 3192082 FTT_0006 Francisella tularensis subsp. tularensis SCHU S4 MFS superfamily proline/ betaine transporter YP_169087.1 4661 D 177416 CDS YP_169088.1 56707192 3192542 6044..7822 1 NC_006570.2 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 7822 aspS 3192542 aspS Francisella tularensis subsp. tularensis SCHU S4 aspartyl-tRNA synthetase YP_169088.1 6044 D 177416 CDS YP_169089.1 56707193 3192126 complement(11434..12216) 1 NC_006570.2 ORF ftt0013c; lipoprotein 12216 3192126 FTT_0013c Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_169089.1 11434 R 177416 CDS YP_169090.1 56707194 3192132 complement(12456..12854) 1 NC_006570.2 ORF ftt0014c; hypothetical protein 12854 3192132 FTT_0014c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169090.1 12456 R 177416 CDS YP_169091.1 56707195 3191235 13182..14480 1 NC_006570.2 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 14480 purB 3191235 purB Francisella tularensis subsp. tularensis SCHU S4 adenylosuccinate lyase YP_169091.1 13182 D 177416 CDS YP_169092.1 56707196 3192139 14514..15092 1 NC_006570.2 ORF ftt0016; hypothetical protein 15092 3192139 FTT_0016 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169092.1 14514 D 177416 CDS YP_169093.1 56707197 3192135 15179..16720 1 NC_006570.2 Similar to Q8PAK3 Toxin secretion ABC transporter ATP-binding protein from Xanthomonas axonopodis (563 aa). FASTA: opt: 454 Z-score: 516.4 E(): 7.1e-21 Smith-Waterman score: 454; 24.395identity in 496 aa overlap ORF ftt0017; hypothetical protein 16720 3192135 FTT_0017 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169093.1 15179 D 177416 CDS YP_169094.1 56707198 3192140 16728..17801 1 NC_006570.2 Similar to Q8PMA5 RND efflux membrane fusion protein from Xanthomonas axonopodis (354 aa). FASTA: opt: 851 Z-score: 971.0 E(): 3.4e-46 Smith-Waterman score: 851; 37.846 identity in 325 aa overlap ORF ftt0018; secretion protein 17801 3192140 FTT_0018 Francisella tularensis subsp. tularensis SCHU S4 secretion protein YP_169094.1 16728 D 177416 CDS YP_169095.1 56707199 3191550 17884..18165 1 NC_006570.2 Similar to Q82T57 Glu-tRNAGln amidotransferase C subunit from Nitrosomonas europaea (95 aa). FASTA:i opt: 188 Z-score: 259.9 E(): 1.4e-06 Smith-Waterman score: 188; 31.818 identity in 88 aa overlap; Glu-tRNAGln amidotransferase C subunit 18165 gatC 3191550 gatC Francisella tularensis subsp. tularensis SCHU S4 Glu-tRNAGln amidotransferase C subunit YP_169095.1 17884 D 177416 CDS YP_169096.1 56707200 3191915 18174..19619 1 NC_006570.2 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 19619 gatA 3191915 gatA Francisella tularensis subsp. tularensis SCHU S4 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_169096.1 18174 D 177416 CDS YP_169097.1 56707201 3191603 19622..21043 1 NC_006570.2 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 21043 gatB 3191603 gatB Francisella tularensis subsp. tularensis SCHU S4 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_169097.1 19622 D 177416 CDS YP_169098.1 56707202 3192103 21058..21465 1 NC_006570.2 ORF ftt0022; hypothetical protein 21465 3192103 FTT_0022 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169098.1 21058 D 177416 CDS YP_169101.1 56707205 3192092 complement(23022..24551) 1 NC_006570.2 ORF ftt0025c; hypothetical protein 24551 3192092 FTT_0025c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169101.1 23022 R 177416 CDS YP_169102.1 56707206 3192094 complement(24636..25826) 1 NC_006570.2 Similar to Q9HWP5 Probable MFS transporter from Pseudomonas aeruginosa (402 aa). FASTA: opt: 568 Z-score: 586.0 E(): 9.5e-25 Smith-Waterman score: 568; 26.425 identity in 386 aa overlap ORF ftt0026c; hypothetical protein 25826 3192094 FTT_0026c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169102.1 24636 R 177416 CDS YP_169103.1 56707207 3192305 complement(25842..27095) 1 NC_006570.2 Similar to DCDA_BACSU (P23630) Diaminopimelate decarboxylase from Bacillus subtilis (441 aa). FASTA: opt: 437 Z-score: 538.0 E(): 4.5e-22 Smith-Waterman score: 437; 27.295 identity in 414 aa overlap; diaminopimelate decarboxylase 27095 lysA1 3192305 lysA1 Francisella tularensis subsp. tularensis SCHU S4 diaminopimelate decarboxylase YP_169103.1 25842 R 177416 CDS YP_169104.1 56707208 3192141 complement(27088..28350) 1 NC_006570.2 Similar to YCEE_ECOLI (P25744) Hypothetical transport protein yce from E. coli (408 aa). FASTA: opt: 364 Z-score: 408.7 E(): 7.1e-15 Smith-Waterman score: 450; 26.582 identity in 395 aa overlap ORF ftt0028c; hypothetical protein 28350 3192141 FTT_0028c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169104.1 27088 R 177416 CDS YP_169105.1 56707209 3192145 complement(28357..30276) 1 NC_006570.2 Similar to AAO89973 (Q83EA5) FrgA protein from Coxiella burnetii (528 aa). FASTA: opt: 1047 Z-score: 1237.4 E(): 4.9e-61 Smith-Waterman score: 1053; 34.051 identity in 511 aa overlap ORF ftt0029c; hypothetical protein 30276 3192145 FTT_0029c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169105.1 28357 R 177416 CDS YP_169106.1 56707210 3191536 complement(30529..30951) 1 NC_006570.2 Similar to FUR_ECOLI (P06975) Ferric uptake regulation protein from E. coli (148 aa). FASTA: opt: 396 Z-score: 515.7 E(): 7.8e-21 Smith-Waterman score: 396; 40.714 identity in 140 aa overlap; ferric uptake regulation protein 30951 fur 3191536 fur Francisella tularensis subsp. tularensis SCHU S4 ferric uptake regulation protein YP_169106.1 30529 R 177416 CDS YP_169107.1 56707211 3191755 31160..31558 1 NC_006570.2 Similar to Q9A6X0 NADH dehydrogenase I, A subunit from Caulobacter crescentus (125 aa). FASTA: opt: 398 Z-score: 508.1 E(): 2.1e-20 Smith-Waterman score: 398; 46.565 identity in 131 aa overlap; NADH dehydrogenase I subunit A 31558 nuoA 3191755 nuoA Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase I subunit A YP_169107.1 31160 D 177416 CDS YP_169108.1 56707212 3191756 31549..32025 1 NC_006570.2 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 32025 nuoB 3191756 nuoB Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase subunit B YP_169108.1 31549 D 177416 CDS YP_169109.1 56707213 3192334 32022..32672 1 NC_006570.2 Similar to NUOC_NEIMB (Q9K1C1) NADH-quinone oxidoreductase chain from Neisseria meningitidis (197 aa). FASTA: opt: 516 Z-score: 659.3 E(): 7.8e-29 Smith-Waterman score: 568; 44.286identity in 210 aa overlap; NADH dehydrogenase I 32672 nuoC 3192334 nuoC Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase I YP_169109.1 32022 D 177416 CDS YP_169110.1 56707214 3191807 32694..33947 1 NC_006570.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 33947 nuoD 3191807 nuoD Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase subunit D YP_169110.1 32694 D 177416 CDS YP_169111.1 56707215 3191813 33957..34445 1 NC_006570.2 Similar to Q83BQ9 NADH dehydrogenase I, E subunit from Xanthomonas campestris (174 aa). FASTA: opt: 528 Z-score: 689.7 E(): 1.6e-30 Smith-Waterman score: 528; 52.318 identity in 151 aa overlap; NADH dehydrogenase I subunit E 34445 nuoE 3191813 nuoE Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase I subunit E YP_169111.1 33957 D 177416 CDS YP_169112.1 56707216 3191815 34452..35726 1 NC_006570.2 Similar to Q83BR0 NADH dehydrogenase I, F subunit from Coxiella burnetti (422 aa). FASTA: opt: 1851 Z-score: 2306.0 E(): 1.5e-120 Smith-Waterman score: 1851; 61.848 identity in 422 aa overlap; NADH dehydrogenase I subunit F 35726 nuoF 3191815 nuoF Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase I subunit F YP_169112.1 34452 D 177416 CDS YP_169113.1 56707217 3191823 35744..38110 1 NC_006570.2 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit G 38110 nuoG 3191823 nuoG Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase subunit G YP_169113.1 35744 D 177416 CDS YP_169114.1 56707218 3191826 38112..39122 1 NC_006570.2 Similar to Q83BR2 NADH dehydrogenase I, H subunit from Coxiella burnetii (340 aa). FASTA: opt: 1510 Z-score: 1695.3 E(): 1.5e-86 Smith-Waterman score: 1510; 60.843 identity in 332 aa overlap; NADH dehydrogenase I subunit H 39122 nuoH 3191826 nuoH Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase I subunit H YP_169114.1 38112 D 177416 CDS YP_169115.1 56707219 3191832 39136..39624 1 NC_006570.2 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 39624 nuoI 3191832 nuoI Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase subunit I YP_169115.1 39136 D 177416 CDS YP_169116.1 56707220 3191843 39629..40234 1 NC_006570.2 Similar to Q9K1B2 NADH dehydrogenase I, J subunit from Neisseria meningitidis (223 aa). FASTA: opt: 387 Z-score: 452.6 E(): 2.6e-17 Smith-Waterman score: 387; 38.191 identity in 199 aa overlap; NADH dehydrogenase I subunit J 40234 nuoJ 3191843 nuoJ Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase I subunit J YP_169116.1 39629 D 177416 CDS YP_169117.1 56707221 3191853 40212..40544 1 NC_006570.2 Similar to Q9A6Y6 NADH dehydrogenase I, K subunit from Caulobacter crescentus (101 aa). FASTA: opt: 300 Z-score: 405.7 E(): 1e-14 Smith-Waterman score: 300; 43.000 identity in 100 aa overlap; NADH dehydrogenase I subunit K 40544 nuoK 3191853 nuoK Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase I subunit K YP_169117.1 40212 D 177416 CDS YP_169118.1 56707222 3192436 40554..42563 1 NC_006570.2 Similar to Q83BR6 NADH dehydrogenase I, L subunit from Coxiella burnetii (653 aa). FASTA: opt: 1934 Z-score: 2065.6 E(): 3.6e-107 Smith-Waterman score: 2090; 50.760 identity in 658 aa overlap; NADH dehydrogenase I subunit L 42563 nuoL 3192436 nuoL Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase I subunit L YP_169118.1 40554 D 177416 CDS YP_169119.1 56707223 3191014 42589..44178 1 NC_006570.2 Similar to Q83BR7 NADH dehydrogenase I, M subunit from Coxiella burnetii (506 aa). FASTA: opt: 1099 Z-score: 1147.9 E(): 4.8e-56 Smith-Waterman score: 1659; 47.228 identity in 523 aa overlap; NADH dehydrogenase I subunit M 44178 nuoM 3191014 nuoM Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase I subunit M YP_169119.1 42589 D 177416 CDS YP_169120.1 56707224 3191022 44188..45645 1 NC_006570.2 Similar to Q83BR8 NADH dehydrogenase I, N subunit from Coxiella burnetii (482 aa). FASTA: opt: 1231 Z-score: 1222.9 E(): 3.2e-60 Smith-Waterman score: 1231; 39.914 identity in 466 aa overlap; NADH dehydrogenase I subunit N 45645 nuoN 3191022 nuoN Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase I subunit N YP_169120.1 44188 D 177416 CDS YP_169121.1 56707225 3192148 45721..45915 1 NC_006570.2 Similar to Q8DDC7 Conserved hypothetical protein from Vibrio vulnificus (83 aa). FASTA: opt: 165 Z-score: 224.7 E(): 0.00013 Smith-Waterman score: 165; 45.763 identity in 59 aa overlap ORF ftt0045; hypothetical protein 45915 3192148 FTT_0045 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169121.1 45721 D 177416 CDS YP_169122.1 56707226 3192418 47462..48496 1 NC_006570.2 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 48496 hemE 3192418 hemE Francisella tularensis subsp. tularensis SCHU S4 uroporphyrinogen decarboxylase YP_169122.1 47462 D 177416 CDS YP_169123.1 56707227 3192150 48716..49174 1 NC_006570.2 Similar to Q88DV5 Conserved hypothetical protein from Pseudomonas putida (169 aa). FASTA: opt: 402 Z-score: 490.7 E(): 1.7e-19 Smith-Waterman score: 402; 43.243 identity in 148 aa overlap ORF ftt0048; hypothetical protein 49174 3192150 FTT_0048 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169123.1 48716 D 177416 CDS YP_169124.1 56707228 3191035 49192..50661 1 NC_006570.2 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 50661 nusA 3191035 nusA Francisella tularensis subsp. tularensis SCHU S4 transcription elongation factor NusA YP_169124.1 49192 D 177416 CDS YP_169125.1 56707229 3192398 50700..53240 1 NC_006570.2 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 53240 infB 3192398 infB Francisella tularensis subsp. tularensis SCHU S4 translation initiation factor IF-2 YP_169125.1 50700 D 177416 CDS YP_169126.1 56707230 3191646 53243..53674 1 NC_006570.2 Similar to RBFA_ECOLI (P09170) Ribosome-binding factor A from E. coli (132 aa). FASTA: opt: 301 Z-score: 381.1 E(): 2.5e-13 Smith-Waterman score: 301; 41.935 identity in 124 aa overlap; ribosome-binding factor A 53674 rbfA 3191646 rbfA Francisella tularensis subsp. tularensis SCHU S4 ribosome-binding factor A YP_169126.1 53243 D 177416 CDS YP_169127.1 56707231 3192430 53682..54947 1 NC_006570.2 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 54947 hisS 3192430 hisS Francisella tularensis subsp. tularensis SCHU S4 histidyl-tRNA synthetase YP_169127.1 53682 D 177416 CDS YP_169128.1 56707232 3192152 54954..56252 1 NC_006570.2 Similar to AAO90449 (Q83D24) Major facilitator family transporter from Coxiella burnetii (437 aa). FASTA: opt: 908 Z-score: 1023.7 E(): 3.6e-49 Smith-Waterman score: 909; 36.603 identity in 418 aa overlap ORF ftt0053; major facilitator transporter 56252 3192152 FTT_0053 Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_169128.1 54954 D 177416 CDS YP_169129.1 56707233 3190705 56255..57322 1 NC_006570.2 Similar to YHCM_ECOLI (P46442) Hypothetical protein yhcM from E. coli (375 aa). FASTA: opt: 872 Z-score: 1033.2 E(): 1.2e-49 Smith-Waterman score: 898; 39.833 identity in 359 aa overlap ORF ftt0054; ATPase 57322 3190705 FTT_0054 Francisella tularensis subsp. tularensis SCHU S4 ATPase YP_169129.1 56255 D 177416 CDS YP_169130.1 56707234 3191616 57315..58244 1 NC_006570.2 Similar to RLUC_ECOLI (P23851) Ribosomal large subunit pseudouridine synthase C from E. coli (319 aa). FASTA: opt: 791 Z-score: 972.5 E(): 2.8e-46 Smith-Waterman score: 791; 40.777 identity in 309 aa overlap; ribosomal large subunit pseudouridine synthase C 58244 rluC 3191616 rluC Francisella tularensis subsp. tularensis SCHU S4 ribosomal large subunit pseudouridine synthase C YP_169130.1 57315 D 177416 CDS YP_169131.1 56707235 3192153 complement(58246..59550) 1 NC_006570.2 Similar to Q83D24 (Q83D24) Major facilitator family transporter from Coxiella burnetii (437 aa). FASTA: opt: 1028 Z-score: 1172.6 E(): 2e-57 Smith-Waterman score: 1036; 40.187 identity in 428 aa overlap ORF ftt0056c; major facilitator transporter 59550 3192153 FTT_0056c Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_169131.1 58246 R 177416 CDS YP_169132.1 56707236 3192151 59627..60058 1 NC_006570.2 ORF ftt0057; hypothetical protein 60058 3192151 FTT_0057 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169132.1 59627 D 177416 CDS YP_169133.1 56707237 3192531 60111..60902 1 NC_006570.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 60902 atpB 3192531 atpB Francisella tularensis subsp. tularensis SCHU S4 ATP synthase F0F1 subunit A YP_169133.1 60111 D 177416 CDS YP_169134.1 56707238 3192108 60953..61258 1 NC_006570.2 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 61258 atpE 3192108 atpE Francisella tularensis subsp. tularensis SCHU S4 ATP synthase F0F1 subunit C YP_169134.1 60953 D 177416 CDS YP_169135.1 56707239 3191918 61304..61774 1 NC_006570.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 61774 atpF 3191918 atpF Francisella tularensis subsp. tularensis SCHU S4 ATP synthase F0F1 subunit B YP_169135.1 61304 D 177416 CDS YP_169136.1 56707240 3190962 61794..62318 1 NC_006570.2 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 62318 atpH 3190962 atpH Francisella tularensis subsp. tularensis SCHU S4 ATP synthase F0F1 subunit delta YP_169136.1 61794 D 177416 CDS YP_169137.1 56707241 3190736 62337..63878 1 NC_006570.2 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 63878 atpA 3190736 atpA Francisella tularensis subsp. tularensis SCHU S4 ATP synthase F0F1 subunit alpha YP_169137.1 62337 D 177416 CDS YP_169138.1 56707242 3192500 63893..64789 1 NC_006570.2 produces ATP from ADP in the presence of a proton gradient across the membrane; the gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 64789 atpG 3192500 atpG Francisella tularensis subsp. tularensis SCHU S4 ATP synthase F0F1 subunit gamma YP_169138.1 63893 D 177416 CDS YP_169139.1 56707243 3190957 64799..66175 1 NC_006570.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 66175 atpD 3190957 atpD Francisella tularensis subsp. tularensis SCHU S4 ATP synthase F0F1 subunit beta YP_169139.1 64799 D 177416 CDS YP_169140.1 56707244 3192519 66188..66625 1 NC_006570.2 produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit epsilon 66625 atpC 3192519 atpC Francisella tularensis subsp. tularensis SCHU S4 ATP synthase F0F1 subunit epsilon YP_169140.1 66188 D 177416 CDS YP_169141.1 56707245 3192095 66836..69679 1 NC_006570.2 ORF ftt0066; hypothetical protein 69679 3192095 FTT_0066 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169141.1 66836 D 177416 CDS YP_169142.1 56707246 3190708 complement(69696..70025) 1 NC_006570.2 Similar to Q8D879 Glutaredoxin-related protein from Vibrio vulnificus (112 aa). FASTA: opt: 485 Z-score: 630.6 E(): 2.8e-27 Smith-Waterman score: 485; 65.306 identity in 98 aa overlap ORF ftt0067c; glutaredoxin-like protein 70025 3190708 FTT_0067c Francisella tularensis subsp. tularensis SCHU S4 glutaredoxin-like protein YP_169142.1 69696 R 177416 CDS YP_169143.1 56707247 3190713 70161..70739 1 NC_006570.2 Similar to SODF_ECOLI (P09157) Superoxide dismutase [Fe] from E. coli (192 aa). FASTA: opt: 896 Z-score: 1143.2 E(): 8.8e-56 Smith-Waterman score: 896; 66.316 identity in 190 aa overlap; superoxide dismutase 70739 sodB 3190713 sodB Francisella tularensis subsp. tularensis SCHU S4 superoxide dismutase YP_169143.1 70161 D 177416 CDS YP_169144.1 56707248 3190720 complement(70747..70932) 1 NC_006570.2 ORF ftt0069c; hypothetical protein 70932 3190720 FTT_0069c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169144.1 70747 R 177416 CDS YP_169145.1 56707249 3192356 complement(70944..72209) 1 NC_006570.2 Similar to AMPG_ECOLI (P36670) AmpG protein from E. coli (491 aa). FASTA: opt: 996 Z-score: 1121.1 E(): 1.5e-54 Smith-Waterman score: 996; 38.614 identity in 404 aa overlap; major facilitator superfamily transporter 72209 ampG 3192356 ampG Francisella tularensis subsp. tularensis SCHU S4 major facilitator superfamily transporter YP_169145.1 70944 R 177416 CDS YP_169146.1 56707250 3192375 complement(72298..73572) 1 NC_006570.2 Similar to CISY_PSEAE (P14165) Citrate synthase from Pseudomonas aeruginosa (428 aa). FASTA: opt: 1540 Z-score: 1956.3 E(): 4.5e-101 Smith-Waterman score: 1540; 57.353 identity in 408 aa overlap; citrate synthase 73572 gltA 3192375 gltA Francisella tularensis subsp. tularensis SCHU S4 citrate synthase YP_169146.1 72298 R 177416 CDS YP_169147.1 56707251 3191400 73815..74288 1 NC_006570.2 Similar to Q884A1 Succinate dehydrogenase, cytochrome b556 subunit from Pseudomonas syringae (124 aa). FASTA: opt: 332 Z-score: 413.6 E(): 3.8e-15 Smith-Waterman score: 332; 39.844identity in 128 aa overlap; succinate dehydrogenase cytochrome b556 74288 sdhC 3191400 sdhC Francisella tularensis subsp. tularensis SCHU S4 succinate dehydrogenase cytochrome b556 YP_169147.1 73815 D 177416 CDS YP_169148.1 56707252 3192101 74264..74632 1 NC_006570.2 Similar to Q88FA6 Succinate dehydrogenase, hydrophobic membrane anchor protein from Pseudomonas putida (122 aa). FASTA: opt: 242 Z-score: 306.8 E(): 3.4e-09 Smith-Waterman score: 242; 34.677 identity in 124 aa overlap; succinate dehydrogenase hydrophobic membrane anchor protein 74632 sdhD 3192101 sdhD Francisella tularensis subsp. tularensis SCHU S4 succinate dehydrogenase hydrophobic membrane anchor protein YP_169148.1 74264 D 177416 CDS YP_169149.1 56707253 3191590 74645..76438 1 NC_006570.2 Similar to Q9I3D5 Succinate dehydrogenase (A subunit) from Pseudomonas aeruginosa (590 aa). FASTA: opt: 2468 Z-score: 2874.7 E(): 3.2e-152 Smith-Waterman score: 2468; 61.139 identity in 597 aa overlap; succinate dehydrogenase catalytic and NAD/flavoprotein subunit 76438 sdhA 3191590 sdhA Francisella tularensis subsp. tularensis SCHU S4 succinate dehydrogenase catalytic and NAD/flavoprotein subunit YP_169149.1 74645 D 177416 CDS YP_169150.1 56707254 3191270 76456..77157 1 NC_006570.2 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 77157 sdhB 3191270 sdhB Francisella tularensis subsp. tularensis SCHU S4 succinate dehydrogenase iron-sulfur subunit YP_169150.1 76456 D 177416 CDS YP_169151.1 56707255 3190733 77175..80000 1 NC_006570.2 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 80000 sucA 3190733 sucA Francisella tularensis subsp. tularensis SCHU S4 2-oxoglutarate dehydrogenase E1 YP_169151.1 77175 D 177416 CDS YP_169152.1 56707256 3190739 80026..81495 1 NC_006570.2 Similar to Q8EFN9 2-oxoglutarate dehydrogenase,E2 component, dihydrolipoamide succinyltransferase from Shewanella oneidensis (395 aa). FASTA: opt: 1379 Z-score: 1563.0 E(): 3.6e-79 Smith-Waterman score: 1379; 55.949 identity in 395 aa overlap; dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex 81495 sucB 3190739 sucB Francisella tularensis subsp. tularensis SCHU S4 dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex YP_169152.1 80026 D 177416 CDS YP_169153.1 56707257 3191768 81535..82062 1 NC_006570.2 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 82062 apt 3191768 apt Francisella tularensis subsp. tularensis SCHU S4 adenine phosphoribosyltransferase YP_169153.1 81535 D 177416 CDS YP_169154.1 56707258 3191618 82073..83404 1 NC_006570.2 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 83404 glmM 3191618 glmM Francisella tularensis subsp. tularensis SCHU S4 phosphoglucosamine mutase YP_169154.1 82073 D 177416 CDS YP_169155.1 56707259 3191461 83407..84168 1 NC_006570.2 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 84168 tpiA 3191461 tpiA Francisella tularensis subsp. tularensis SCHU S4 triosephosphate isomerase YP_169155.1 83407 D 177416 CDS YP_169156.1 56707260 3192467 84156..84509 1 NC_006570.2 Similar to Q9KU83 Preprotein translocase, SecG subunit from Vibrio cholerae (111 aa). FASTA: opt: 283 Z-score: 369.6 E(): 1.1e-12 Smith-Waterman score: 289; 45.299identity in 117 aa overlap. Together with SecE and SecY forming an integral membrane complex.; preprotein translocase subunit SecG 84509 secG 3192467 secG Francisella tularensis subsp. tularensis SCHU S4 preprotein translocase subunit SecG YP_169156.1 84156 D 177416 CDS YP_169157.1 56707261 3190719 85720..86196 1 NC_006570.2 ORF ftt0083; hypothetical protein 86196 3190719 FTT_0083 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169157.1 85720 D 177416 CDS YP_169158.1 56707262 3192423 complement(86193..87335) 1 NC_006570.2 Similar to Q87V87 Oxygen-independent coproporphyrinogen III oxidase,,from Pseudomonas syringae (404 aa). FASTA: opt: 1156 Z-score: 1386.6 E(): 2.4e-69 Smith-Waterman score: 1156; 46.791 identity in 374 aa overlap; oxygen-independent coproporphyrinogen III oxidase 87335 hemN 3192423 hemN Francisella tularensis subsp. tularensis SCHU S4 oxygen-independent coproporphyrinogen III oxidase YP_169158.1 86193 R 177416 CDS YP_169159.1 56707263 3190725 complement(87340..87717) 1 NC_006570.2 Similar to YWCD_BACSU P39602 Hypothetical protein ywcD from Bacillus subtilis (127 aa). FASTA: opt: 162 Z-score: 223.9 E(): 0.00013 Smith-Waterman score: 162; 26.667 identity in 120 aa overlap ORF ftt0085c; hypothetical protein 87717 3190725 FTT_0085c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169159.1 87340 R 177416 CDS YP_169160.1 56707264 3190724 87787..88665 1 NC_006570.2 Similar to Q9I078 Hypothetical protein PA2765 from Pseudomonas aeruginosa (299 aa). FASTA: opt: 656 Z-score: 793.3 E(): 2.4e-36 Smith-Waterman score: 656; 36.678 identity in 289 aa overlap ORF ftt0086; hypothetical protein 88665 3190724 FTT_0086 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169160.1 87787 D 177416 CDS YP_169161.1 56707265 3192406 88770..91583 1 NC_006570.2 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 91583 acnA 3192406 acnA Francisella tularensis subsp. tularensis SCHU S4 aconitate hydratase YP_169161.1 88770 D 177416 CDS YP_169162.1 56707266 3190704 91678..92706 1 NC_006570.2 Similar to Q8EBZ4 Twitching motility protein PilT from Shewanella oneidensis (345 aa). FASTA: opt: 1226 Z-score: 1391.3 E(): 1.3e-69 Smith-Waterman score: 1226; 57.186 identity in 334 aa overlap Required for pili retraction probably by filament disassembly. Homologous to pilB but which has the opposite effect. Unique to type IV pili.; Type IV pili nucleotide-binding protein 92706 pilT 3190704 pilT Francisella tularensis subsp. tularensis SCHU S4 Type IV pili nucleotide-binding protein YP_169162.1 91678 D 177416 CDS YP_169163.1 56707267 3190741 complement(93768..94214) 1 NC_006570.2 Similar to Q87GR3 Hypothetical protein from Vibrio parahaemolyticus (148 aa). FASTA: opt: 160 Z-score: 212.3 E(): 0.00057 Smith-Waterman score: 160; 29.104 identity in 134 aa overlap ORF ftt0090c; hypothetical protein 94214 3190741 FTT_0090c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169163.1 93768 R 177416 CDS YP_169164.1 56707268 3190938 complement(94225..95187) 1 NC_006570.2 Similar to Q87H27 Cytochrome BD2, subunit II from Vibrio parahaemolyticus (335 aa). FASTA: opt: 573 Z-score: 669.5 E(): 1.9e-29 Smith-Waterman score: 750; 34.743 identity in 331 aa overlap; cytochrome oxidase bd-II subunit II 95187 appB 3190938 appB Francisella tularensis subsp. tularensis SCHU S4 cytochrome oxidase bd-II subunit II YP_169164.1 94225 R 177416 CDS YP_169165.1 56707269 3190730 96803..97684 1 NC_006570.2 Similar to Q8FFI5 Hypothetical protein yfcH from E. coli (297 aa). FASTA: opt: 498 Z-score: 611.0 E(): 3.8e-26 Smith-Waterman score: 498; 32.673 identity in 303 aa overlap ORF ftt0093; hypothetical protein 97684 3190730 FTT_0093 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169165.1 96803 D 177416 CDS YP_169166.1 56707270 3191649 complement(97681..99108) 1 NC_006570.2 Similar to AAO90737 (Q83CA0) Sensor histidine kinase from Coxiella burnetii (478 aa). FASTA: opt: 653 Z-score: 752.8 E(): 4.9e-34 Smith-Waterman score: 677; 29.083 identity in 447 aa overlap Sensory histidine kinase in two-component regulatory system with QseB, regulates flagella and motility by quorum sensing in E. coli, according to Q8X524; sensor histidine kinase 99108 qseC 3191649 qseC Francisella tularensis subsp. tularensis SCHU S4 sensor histidine kinase YP_169166.1 97681 R 177416 CDS YP_169167.1 56707271 3192116 99224..100180 1 NC_006570.2 ORF ftt0095; hypothetical protein 100180 3192116 FTT_0095 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169167.1 99224 D 177416 CDS YP_169168.1 56707272 3192159 100422..101462 1 NC_006570.2 ORF ftt0096; hypothetical protein 101462 3192159 FTT_0096 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169168.1 100422 D 177416 CDS YP_169169.1 56707273 3192161 101596..102141 1 NC_006570.2 ORF ftt0097; hypothetical protein 102141 3192161 FTT_0097 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169169.1 101596 D 177416 CDS YP_169170.1 56707274 3190940 complement(join(102215..102673,102673..102999)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 102999 isftu1 3190940 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169170.1 102215 R 177416 CDS YP_169171.1 56707275 3190803 103101..103844 1 NC_006570.2 ISFtu2. Transposase, member of the IS5 family. Identical to Q8GM03 transposase from Francisella tularensis (247 aa).; transposase 103844 isftu2 3190803 isftu2 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169171.1 103101 D 177416 CDS YP_169172.1 56707276 3192163 104514..105527 1 NC_006570.2 Similar to Y402_RICPR (Q9ZDC9) Hypothetical protein RP402 from Rickettsia prowazekii (317 aa). FASTA: opt: 431 Z-score: 518.0 E(): 5.9e-21 Smith-Waterman score: 432; 28.909 identity in 339 aa overlap ORF ftt0101; hypothetical protein 105527 3192163 FTT_0101 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169172.1 104514 D 177416 CDS YP_169173.1 56707277 3192110 complement(106972..107553) 1 NC_006570.2 ORF ftt0103c; hypothetical protein 107553 3192110 FTT_0103c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169173.1 106972 R 177416 CDS YP_169174.1 56707278 3192109 complement(107798..109075) 1 NC_006570.2 Similar to Q83DX6 Major facilitator family transporter from Coxiella burnetii (421 aa). FASTA: opt: 995 Z-score: 1049.4 E(): 1.5e-50 Smith-Waterman score: 995; 39.066identity in 407 aa overlap ORF ftt0104c; major facilitator transporter 109075 3192109 FTT_0104c Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_169174.1 107798 R 177416 CDS YP_169175.1 56707279 3190746 complement(109207..112320) 1 NC_006570.2 Similar to AAO90606 (Q83CM1) Transporter,AcrB/AcrD/AcrF family from Coxiella burnetii (1019 aa). FASTA: opt: 2662 Z-score: 2840.6 E(): 2.3e-150 Smith-Waterman score: 3071; 45.171identity in 1025 aa overlap ORF ftt0105c; AcrB/AcrD/AcrF family transporter 112320 3190746 FTT_0105c Francisella tularensis subsp. tularensis SCHU S4 AcrB/AcrD/AcrF family transporter YP_169175.1 109207 R 177416 CDS YP_169176.1 56707280 3192105 complement(112320..113693) 1 NC_006570.2 Similar to Q83CM0 Efflux transporter, RND family, MFP subunit from Coxiella burnetti (380 aa). FASTA: opt: 732 Z-score: 824.0 E(): 5.2e-38 Smith-Waterman score: 781; 34.748identity in 377 aa overlap ORF ftt0106c; RND efflux transporter 113693 3192105 FTT_0106c Francisella tularensis subsp. tularensis SCHU S4 RND efflux transporter YP_169176.1 112320 R 177416 CDS YP_169177.1 56707281 3191543 complement(113706..114197) 1 NC_006570.2 Similar to DSBB_NEIMB (Q9JYC6) Disulfide bond formation protein B (disuphide oxidoreductase) from Neisseria meningitidis (162 aa). FASTA: opt: 171 Z-score: 223.1 E(): 0.00014 Smith-Waterman score: 171; 27.344 identity in 128 aa overlap; disulfide bond formation protein 114197 dsbB 3191543 dsbB Francisella tularensis subsp. tularensis SCHU S4 disulfide bond formation protein YP_169177.1 113706 R 177416 CDS YP_169178.1 56707282 3191540 complement(114237..115319) 1 NC_006570.2 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 115319 cca 3191540 cca Francisella tularensis subsp. tularensis SCHU S4 tRNA CCA-pyrophosphorylase YP_169178.1 114237 R 177416 CDS YP_169179.1 56707283 3191929 115424..117253 1 NC_006570.2 lipid A transport protein, ABC transporter,ATP-binding and membrane protein. Similar to Q47908 ValA from Francisella novicida strain U112 (572 aa). FASTA: opt: 3334 Z-score: 3684.8 E(): 2.4e-197 Smith-Waterman score: 3334; 97.810 identity in 548 aa overlap (54-601:13-559). Similar to MSBA_HAEIN (P44407) Lipid A export ATP-binding protein from Haemophilus influenzae (587 aa). FASTA: opt: 1570 Z-score: 1735.1 E(): 9.4e-89 Smith-Waterman score: 1570; 41.913identity in 575 aa overlap.; lipid A transport protein ABC transporter ATP-binding protein/permease 117253 msbA 3191929 msbA Francisella tularensis subsp. tularensis SCHU S4 lipid A transport protein ABC transporter ATP-binding protein/permease YP_169179.1 115424 D 177416 CDS YP_169180.1 56707284 3191936 117259..118227 1 NC_006570.2 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 118227 lpxK 3191936 lpxK Francisella tularensis subsp. tularensis SCHU S4 tetraacyldisaccharide 4'-kinase YP_169180.1 117259 D 177416 CDS YP_169181.1 56707285 3191573 118323..121016 1 NC_006570.2 Similar to AAO91288 (Q83AT5) DNA polymerase I from Coxiella burnetii (895 aa). FASTA: opt: 2961 Z-score: 3329.8 E(): 1.4e-177 Smith-Waterman score: 2961; 52.058 identity in 899 aa overlap; DNA polymerase I 121016 polA 3191573 polA Francisella tularensis subsp. tularensis SCHU S4 DNA polymerase I YP_169181.1 118323 D 177416 CDS YP_169182.1 56707286 3192123 121036..121812 1 NC_006570.2 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 121812 3192123 FTT_0112 Francisella tularensis subsp. tularensis SCHU S4 pantothenate kinase YP_169182.1 121036 D 177416 CDS YP_169183.1 56707287 3191513 121817..123061 1 NC_006570.2 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 123061 deoB 3191513 deoB Francisella tularensis subsp. tularensis SCHU S4 phosphopentomutase YP_169183.1 121817 D 177416 CDS YP_169184.1 56707288 3191515 123024..123785 1 NC_006570.2 Similar to AAP95774 (Q7VMS9) Deoxyribose-phosphate aldolase from Haemophilus ducreyi (258 aa). FASTA: opt: 632 Z-score: 764.1 E(): 1.1e-34 Smith-Waterman score: 632; 42.857 identity in 245 aa overlap; deoxyribose-phosphate aldolase 123785 deoC 3191515 deoC Francisella tularensis subsp. tularensis SCHU S4 deoxyribose-phosphate aldolase YP_169184.1 123024 D 177416 CDS YP_169185.1 56707289 3191032 123775..124974 1 NC_006570.2 Similar to AAP07626 (Q81I17) Nucleoside permease nupC from Bacillus cereus (392 aa). FASTA: opt: 1236 Z-score: 1430.7 E(): 7.7e-72 Smith-Waterman score: 1236; 49.246 identity in 398 aa overlap Paralog of FTT0116; nucleoside permease NUP family protein 124974 nupC1 3191032 nupC1 Francisella tularensis subsp. tularensis SCHU S4 nucleoside permease NUP family protein YP_169185.1 123775 D 177416 CDS YP_169186.1 56707290 3191029 124993..126195 1 NC_006570.2 Similar to (AAP07626) Q81I17 Nucleoside permease nupC from Bacillus cereus (392 aa). FASTA: opt: 1351 Z-score: 1549.9 E(): 1.9e-78 Smith-Waterman score: 1351; 52.381 identity in 399 aa overlap Paralog of FTT0115; nucleoside permease NUP family protein 126195 nupC1 3191029 nupC1 Francisella tularensis subsp. tularensis SCHU S4 nucleoside permease NUP family protein YP_169186.1 124993 D 177416 CDS YP_169187.1 56707291 3190791 126208..126837 1 NC_006570.2 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 126837 tmk 3190791 tmk Francisella tularensis subsp. tularensis SCHU S4 thymidylate kinase YP_169187.1 126208 D 177416 CDS YP_169188.1 56707292 3191238 126899..128476 1 NC_006570.2 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 128476 prfC 3191238 prfC Francisella tularensis subsp. tularensis SCHU S4 peptide chain release factor 3 YP_169188.1 126899 D 177416 CDS YP_169189.1 56707293 3190765 128551..129867 1 NC_006570.2 ORF ftt0119; hypothetical protein 129867 3190765 FTT_0119 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169189.1 128551 D 177416 CDS YP_169190.1 56707294 3191702 129864..130895 1 NC_006570.2 Similar to Q9I6C1 Signal recognition particle receptor FtsY from Pseudomonas aeruginosa (455 aa). FASTA: opt: 1262 Z-score: 1403.4 E(): 2.8e-70 Smith-Waterman score: 1262; 61.935identity in 310 aa overlap; signal recognition particle receptor FtsY 130895 ftsY 3191702 ftsY Francisella tularensis subsp. tularensis SCHU S4 signal recognition particle receptor FtsY YP_169190.1 129864 D 177416 CDS YP_169191.1 56707295 3191925 130986..133208 1 NC_006570.2 Similar to Q88C31 DNA helicase II from Pseudomonas putida (728 aa). FASTA: opt: 1880 Z-score: 2129.9 E(): 9.6e-111 Smith-Waterman score: 2083; 45.867 identity in 750 aa overlap; DNA helicase II 133208 uvrD 3191925 uvrD Francisella tularensis subsp. tularensis SCHU S4 DNA helicase II YP_169191.1 130986 D 177416 CDS YP_169192.1 56707296 3191178 136633..137601 1 NC_006570.2 Similar to Q8D8A2 Oligopeptide ABC transporter,ATP-binding protein D from Vibrio vulnificus (324 aa). FASTA: opt: 1202 Z-score: 1353.8 E(): 1.6e-67 Smith-Waterman score: 1202; 56.270 identity in 311 aa overlap; oligopeptide ABC transporter ATP-binding protein 137601 oppD 3191178 oppD Francisella tularensis subsp. tularensis SCHU S4 oligopeptide ABC transporter ATP-binding protein YP_169192.1 136633 D 177416 CDS YP_169193.1 56707297 3191181 137602..138576 1 NC_006570.2 Similar to OPPF_HAEIN (P45051) Oligopeptide transport ATP-binding oppF from Haemophilus influenzae (332 aa). FASTA: opt: 1227 Z-score: 1398.5 E(): 5.3e-70 Smith-Waterman score: 1227; 56.790 identity in 324 aa overlap; oligopeptide ABC transporter ATP-binding protein 138576 oppF 3191181 oppF Francisella tularensis subsp. tularensis SCHU S4 oligopeptide ABC transporter ATP-binding protein YP_169193.1 137602 D 177416 CDS YP_169194.1 56707298 3190764 complement(138580..139782) 1 NC_006570.2 Similar to Q83CF6 Major facilitator family transporter from Coxiella burnetii (443 aa). FASTA: opt: 488 Z-score: 542.0 E(): 2.7e-22 Smith-Waterman score: 490; 27.621identity in 391 aa overlap ORF ftt0127c; major facilitator transporter 139782 3190764 FTT_0127c Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_169194.1 138580 R 177416 CDS YP_169195.1 56707299 3190766 139916..140497 1 NC_006570.2 ORF ftt0128; hypothetical protein 140497 3190766 FTT_0128 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169195.1 139916 D 177416 CDS YP_169196.1 56707300 3190769 140641..141909 1 NC_006570.2 Similar to Q83BM0 (Q83BM0) Major facilitator family transporter from Coxiella burnetii (428 aa). FASTA: opt: 497 Z-score: 533.3 E(): 8.2e-22 Smith-Waterman score: 529; 26.355 identity in 406 aa overlap ORF ftt0129; major facilitator transporter 141909 3190769 FTT_0129 Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_169196.1 140641 D 177416 CDS YP_169197.1 56707301 3192359 141966..143474 1 NC_006570.2 Similar to GLPK_THETN (Q8R8J4) Glycerol kinase from Thermoanaerobacter tengcongensis (497 aa). FASTA: opt: 2233 Z-score: 2691.0 E(): 5.3e-142 Smith-Waterman score: 2233; 66.333 identity in 499 aa overlap. This CDS is disrupted by the insertion of an ISFtu1 element occurring very near the C-terminal end. It is not clear whether this insertion affects the function of the protein; glycerol kinase 143474 glpK 3192359 glpK Francisella tularensis subsp. tularensis SCHU S4 glycerol kinase YP_169197.1 141966 D 177416 CDS YP_169198.1 56707302 3190973 complement(join(143567..144025,144025..144351)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 144351 isftu1 3190973 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169198.1 143567 R 177416 CDS YP_169199.1 56707303 3191077 144667..146199 1 NC_006570.2 Similar to O51259 Glycerol-3-phosphate dehydrogenase, anaerobic, from Borrelia burgdorferii (527 aa). FASTA: opt: 1330 Z-score: 1506.9 E(): 4.8e-76 Smith-Waterman score: 1330; 43.333 identity in 510 aa overlap; anaerobic glycerol-3-phosphate dehydrogenase 146199 glpA 3191077 glpA Francisella tularensis subsp. tularensis SCHU S4 anaerobic glycerol-3-phosphate dehydrogenase YP_169199.1 144667 D 177416 CDS YP_169200.1 56707304 3192242 146209..146973 1 NC_006570.2 Similar to CAD75967 (Q7UMF0) Probable glycerol uptake facilitator protein from Rhodopirelulla baltica (271 aa). FASTA: opt: 796 Z-score: 888.1 E(): 1.4e-41 Smith-Waterman score: 796; 50.209 identity in 239 aa overlap; glycerol uptake facilitator protein 146973 glpF 3192242 glpF Francisella tularensis subsp. tularensis SCHU S4 glycerol uptake facilitator protein YP_169200.1 146209 D 177416 CDS YP_169201.1 56707305 3190771 146977..147690 1 NC_006570.2 ORF ftt0134; hypothetical protein 147690 3190771 FTT_0134 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169201.1 146977 D 177416 CDS YP_169202.1 56707306 3190774 148165..149580 1 NC_006570.2 Similar to AAQ00172 (Q7VBG7) DNA helicase related to phage enzyme from Prochlorococcus marinus (479 aa) FASTA: opt: 386 Z-score: 446.1 E(): 5.9e-17 Smith-Waterman score: 386; 26.681 identity in 476 aa overlap ORF ftt0136; helicase 149580 3190774 FTT_0136 Francisella tularensis subsp. tularensis SCHU S4 helicase YP_169202.1 148165 D 177416 CDS YP_169203.1 56707307 3190712 150045..151229 1 NC_006570.2 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 151229 tufA 3190712 tufA Francisella tularensis subsp. tularensis SCHU S4 elongation factor Tu YP_169203.1 150045 D 177416 CDS YP_169204.1 56707308 3191695 151421..151891 1 NC_006570.2 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 151891 secE 3191695 secE Francisella tularensis subsp. tularensis SCHU S4 preprotein translocase subunit SecE YP_169204.1 151421 D 177416 CDS YP_169205.1 56707309 3191046 151907..152440 1 NC_006570.2 Similar to NUSG_VIBVU (Q8DD25) Transcription antitermination protein nusG from Vibrio vulnificus (181 aa). FASTA: opt: 687 Z-score: 868.9 E(): 1.7e-40 Smith-Waterman score: 687; 58.621 identity in 174 aa overlap; transcription antitermination protein nusG 152440 nusG 3191046 nusG Francisella tularensis subsp. tularensis SCHU S4 transcription antitermination protein nusG YP_169205.1 151907 D 177416 CDS YP_169206.1 56707310 3192014 152509..152943 1 NC_006570.2 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 152943 rplK 3192014 rplK Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L11 YP_169206.1 152509 D 177416 CDS YP_169207.1 56707311 3192023 152946..153641 1 NC_006570.2 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 153641 rplA 3192023 rplA Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L1 YP_169207.1 152946 D 177416 CDS YP_169208.1 56707312 3192015 153811..154329 1 NC_006570.2 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 154329 rplJ 3192015 rplJ Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L10 YP_169208.1 153811 D 177416 CDS YP_169209.1 56707313 3192013 154392..154769 1 NC_006570.2 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 154769 rplL 3192013 rplL Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L7/L12 YP_169209.1 154392 D 177416 CDS YP_169210.1 56707314 3191982 154923..158999 1 NC_006570.2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 158999 rpoB 3191982 rpoB Francisella tularensis subsp. tularensis SCHU S4 DNA-directed RNA polymerase subunit beta YP_169210.1 154923 D 177416 CDS YP_169211.1 56707315 3191980 159061..163314 1 NC_006570.2 Similar to Q9AAU1 (Q9AAU1) DNA-directed RNA polymerase, beta subunit from Caulobacter crescentus (1396 aa). FASTA: opt: 5089 Z-score: 5550.7 E(): 0 Smith-Waterman score: 5089; 56.626identity in 1381 aa overlap; DNA-directed RNA polymerase subunit beta 163314 rpoC 3191980 rpoC Francisella tularensis subsp. tularensis SCHU S4 DNA-directed RNA polymerase subunit beta YP_169211.1 159061 D 177416 CDS YP_169212.1 56707316 3190778 163417..163653 1 NC_006570.2 ORF ftt0146; hypothetical protein 163653 3190778 FTT_0146 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169212.1 163417 D 177416 CDS YP_169213.1 56707317 3192378 163653..164663 1 NC_006570.2 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 164663 gcp 3192378 gcp Francisella tularensis subsp. tularensis SCHU S4 DNA-binding/iron metalloprotein/AP endonuclease YP_169213.1 163653 D 177416 CDS YP_169214.1 56707318 3190777 164777..165943 1 NC_006570.2 Similar to Q27437 Stearoyl-CoA desaturase from Amblyomma americanum (317 aa). FASTA: opt: 653 Z-score: 747.5 E(): 9.6e-34 Smith-Waterman score: 653; 36.897 identity in 290 aa overlap ORF ftt0148; fatty acid desaturase 165943 3190777 FTT_0148 Francisella tularensis subsp. tularensis SCHU S4 fatty acid desaturase YP_169214.1 164777 D 177416 CDS YP_169215.1 56707319 3190826 complement(166155..167315) 1 NC_006570.2 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 167315 metK 3190826 metK Francisella tularensis subsp. tularensis SCHU S4 S-adenosylmethionine synthetase YP_169215.1 166155 R 177416 CDS YP_169216.1 56707320 3192515 167609..167857 1 NC_006570.2 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 167857 rpsP 3192515 rpsP Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S16 YP_169216.1 167609 D 177416 CDS YP_169217.1 56707321 3191619 167900..168409 1 NC_006570.2 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 168409 rimM 3191619 rimM Francisella tularensis subsp. tularensis SCHU S4 16S rRNA-processing protein RimM YP_169217.1 167900 D 177416 CDS YP_169218.1 56707322 3192286 168806..169570 1 NC_006570.2 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 169570 trmD 3192286 trmD Francisella tularensis subsp. tularensis SCHU S4 tRNA (guanine-N(1)-)-methyltransferase YP_169218.1 168806 D 177416 CDS YP_169219.1 56707323 3192004 169570..169917 1 NC_006570.2 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 169917 rplS 3192004 rplS Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L19 YP_169219.1 169570 D 177416 CDS YP_169220.1 56707324 3192118 170083..170961 1 NC_006570.2 Similar to Q7ZAJ8 (Q7ZAJ8) Integrase/recombinase XerD from Shewanella oneidensis (300 aa). FASTA: opt: 1039 Z-score: 1285.0 E(): 1.1e-63 Smith-Waterman score: 1039; 52.414 identity in 290 aa overlap; integrase/recombinase 170961 xerD 3192118 xerD Francisella tularensis subsp. tularensis SCHU S4 integrase/recombinase YP_169220.1 170083 D 177416 CDS YP_169221.1 56707325 3190781 171078..171929 1 NC_006570.2 Similar to Q87HU0 oxidoreductase iron/ascorbate from Vibrio parahaemolyticus (279 aa). FASTA: opt: 944 Z-score: 1155.0 E(): 1.9e-56 Smith-Waterman score: 944; 49.110 identity in 281 aa overlap ORF ftt0155; oxidoreductase iron/ascorbate family protein 171929 3190781 FTT_0155 Francisella tularensis subsp. tularensis SCHU S4 oxidoreductase iron/ascorbate family protein YP_169221.1 171078 D 177416 CDS YP_169222.1 56707326 3190784 171934..172518 1 NC_006570.2 Similar to Q83EI5 Acid phosphatase, class B from Coxiella burnetti (221 aa). FASTA: opt: 326 Z-score: 430.9 E(): 4.1e-16 Smith-Waterman score: 326; 32.642identity in 193 aa overlap ORF ftt0156; acid phosphatase 172518 3190784 FTT_0156 Francisella tularensis subsp. tularensis SCHU S4 acid phosphatase YP_169222.1 171934 D 177416 CDS YP_169223.1 56707327 3190874 complement(172515..173399) 1 NC_006570.2 Similar to Q8XMR0 Probable lic-1 operon protein from Clostridium perfringens (322 aa). FASTA: opt: 370 Z-score: 410.4 E(): 5.7e-15 Smith-Waterman score: 396; 30.492 identity in 305 aa overlap ORF ftt0157c; licB-like transmembrane protein 173399 3190874 FTT_0157c Francisella tularensis subsp. tularensis SCHU S4 licB-like transmembrane protein YP_169223.1 172515 R 177416 CDS YP_169224.1 56707328 3192337 complement(173531..174139) 1 NC_006570.2 ORF ftt0158c; hypothetical protein 174139 3192337 FTT_0158c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169224.1 173531 R 177416 CDS YP_169225.1 56707329 3190819 complement(174216..175037) 1 NC_006570.2 ORF ftt0159c; hypothetical protein 175037 3190819 FTT_0159c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169225.1 174216 R 177416 CDS YP_169226.1 56707330 3191741 175200..175667 1 NC_006570.2 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 175667 nudH 3191741 nudH Francisella tularensis subsp. tularensis SCHU S4 dinucleoside polyphosphate hydrolase YP_169226.1 175200 D 177416 CDS YP_169227.1 56707331 3192299 complement(175677..176303) 1 NC_006570.2 Similar to Q8FXE8 PAP2 family protein from Brucella suis (325 aa). FASTA: opt: 314 Z-score: 375.8 E(): 4.8e-13 Smith-Waterman score: 314; 31.915identity in 188 aa overlap ORF ftt0161c; PAP2 family protein 176303 3192299 FTT_0161c Francisella tularensis subsp. tularensis SCHU S4 PAP2 family protein YP_169227.1 175677 R 177416 CDS YP_169228.1 56707332 3192487 176377..176901 1 NC_006570.2 Similar to Q88PQ9 N-acetyl-anhydromuramyl-L-alanine amidase ampD from Pseudomonas putida (190 aa). FASTA: opt: 623 Z-score: 809.4 E(): 3.4e-37 Smith-Waterman score: 623; 52.000 identity in 175 aa overlap; N-acetyl-anhydromuranmyl-L-alanine amidase 176901 ampD 3192487 ampD Francisella tularensis subsp. tularensis SCHU S4 N-acetyl-anhydromuranmyl-L-alanine amidase YP_169228.1 176377 D 177416 CDS YP_169229.1 56707333 3191416 complement(176959..178842) 1 NC_006570.2 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 178842 parE 3191416 parE Francisella tularensis subsp. tularensis SCHU S4 DNA topoisomerase IV subunit B YP_169229.1 176959 R 177416 CDS YP_169230.1 56707334 3192407 complement(178932..180113) 1 NC_006570.2 Similar to Q9KRK6 Multidrug resistance protein from Vibrio cholerae (401 aa). FASTA: opt: 579 Z-score: 614.0 E(): 2.6e-26 Smith-Waterman score: 579; 28.989identity in 376 aa overlap ORF ftt0164c; eflux protein 180113 3192407 FTT_0164c Francisella tularensis subsp. tularensis SCHU S4 eflux protein YP_169230.1 178932 R 177416 CDS YP_169231.1 56707335 3192524 complement(180113..181483) 1 NC_006570.2 Similar to Q88PJ4 Conserved hypothetical protein from Pseudomonas putida (380 aa). FASTA: opt: 644 Z-score: 755.3 E(): 3.5e-34 Smith-Waterman score: 646; 29.268 identity in 369 aa overlap ORF ftt0165c; lipoprotein 181483 3192524 FTT_0165c Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_169231.1 180113 R 177416 CDS YP_169232.1 56707336 3192512 complement(181486..182142) 1 NC_006570.2 Similar to Q8FF57 Hypothetical protein yfgM from E. coli (206 aa). FASTA: opt: 155 Z-score: 188.7 E(): 0.012 Smith-Waterman score: 188; 27.778 identity in 198 aa overlap ORF ftt0166c; hypothetical protein 182142 3192512 FTT_0166c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169232.1 181486 R 177416 CDS YP_169233.1 56707337 3192414 182323..183573 1 NC_006570.2 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 183573 hemA 3192414 hemA Francisella tularensis subsp. tularensis SCHU S4 glutamyl-tRNA reductase YP_169233.1 182323 D 177416 CDS YP_169234.1 56707338 3191241 183574..184659 1 NC_006570.2 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 184659 prfA 3191241 prfA Francisella tularensis subsp. tularensis SCHU S4 peptide chain release factor 1 YP_169234.1 183574 D 177416 CDS YP_169235.1 56707339 3191135 184652..185506 1 NC_006570.2 ORF ftt0169; HemK protein 185506 3191135 FTT_0169 Francisella tularensis subsp. tularensis SCHU S4 HemK protein YP_169235.1 184652 D 177416 CDS YP_169236.1 56707340 3190954 join(185991..186317,186317..186775) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 186775 isftu1 3190954 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169236.1 185991 D 177416 CDS YP_169237.1 56707341 3191454 188216..188785 1 NC_006570.2 Similar to Q83A22 Hypothetical protein from Coxiella burnetti (192 aa). FASTA: opt: 440 Z-score: 543.8 E(): 2.1e-22 Smith-Waterman score: 440; 37.634 identity in 186 aa overlap ORF ftt0174; hypothetical protein 188785 3191454 FTT_0174 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169237.1 188216 D 177416 CDS YP_169238.1 56707342 3191373 complement(188779..189561) 1 NC_006570.2 Similar to AAO80856 (Q836Q5) ABC transporter, ATP-binding protein (269 aa). FASTA: opt: 738 Z-score: 809.5 E(): 3.1e-37 Smith-Waterman score: 738; 43.137 identity in 255 aa overlap missing 90 aa at C-terminus ORF ftt0175c; ABC transporter ATP-binding protein 189561 3191373 FTT_0175c Francisella tularensis subsp. tularensis SCHU S4 ABC transporter ATP-binding protein YP_169238.1 188779 R 177416 CDS YP_169239.1 56707343 3191370 complement(191745..192170) 1 NC_006570.2 Similar to Q88IP2 Acetyltransferase, GNAT family from Pseudomonas putida (364 aa). FASTA: opt: 250 Z-score: 324.7 E(): 3.1e-10 Smith-Waterman score: 250; 34.559 identity in 136 aa overlap ORF ftt0177c; acetyltransferase 192170 3191370 FTT_0177c Francisella tularensis subsp. tularensis SCHU S4 acetyltransferase YP_169239.1 191745 R 177416 CDS YP_169240.1 56707344 3191620 complement(192157..193626) 1 NC_006570.2 Similar to Q9KPN3 Ribosomal protein S6 modification protein-related protein from Vibrio cholerae (483 aa). FASTA: opt: 1367 Z-score: 1648.7 E(): 6.1e-84 Smith-Waterman score: 1367; 43.149 identity in 489 aa overlap; 30S ribosomal protein S6 193626 rimK 3191620 rimK Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S6 YP_169240.1 192157 R 177416 CDS YP_169241.1 56707345 3191367 195907..196797 1 NC_006570.2 Similar to Q8DDF5 1-acyl-sn-glycerol-3-phosphate acyltransferase from Vibrio vulnificus (271 aa). FASTA: opt: 749 Z-score: 902.5 E(): 2e-42 Smith-Waterman score: 749; 40.370 identity in 270 aa overlap ORF ftt0180; acyltransferase 196797 3191367 FTT_0180 Francisella tularensis subsp. tularensis SCHU S4 acyltransferase YP_169241.1 195907 D 177416 CDS YP_169242.1 56707346 3191366 complement(197194..197730) 1 NC_006570.2 Similar to Q9X885 small integral membrane protein from Streptomyces coelicolor (167 aa). FASTA: opt: 262 Z-score: 342.1 E(): 3.6e-11 Smith-Waterman score: 262; 30.723 identity in 166 aa overlap ORF ftt0181c; hypothetical protein 197730 3191366 FTT_0181c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169242.1 197194 R 177416 CDS YP_169243.1 56707347 3191365 complement(197828..198370) 1 NC_006570.2 Similar to Q8D257 YrdC protein from Wigglesworthia glossinidia (194 aa). FASTA: opt: 374 Z-score: 473.0 E(): 1.9e-18 Smith-Waterman score: 374; 39.130 identity in 184 aa overlap ORF ftt0182c; Sua5/YciO/YrdC family protein 198370 3191365 FTT_0182c Francisella tularensis subsp. tularensis SCHU S4 Sua5/YciO/YrdC family protein YP_169243.1 197828 R 177416 CDS YP_169244.1 56707348 3191976 complement(198487..200157) 1 NC_006570.2 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 200157 rpsA 3191976 rpsA Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S1 YP_169244.1 198487 R 177416 CDS YP_169245.1 56707349 3191361 200305..200766 1 NC_006570.2 Similar to Q83DS3 Zinc-binding domain protein from Coxiella burnetii (142 aa). FASTA: opt: 473 Z-score: 642.4 E(): 6.8e-28 Smith-Waterman score: 473; 52.817 identity in 142 aa overlap ORF ftt0184; zinc-binding domain-containing protein 200766 3191361 FTT_0184 Francisella tularensis subsp. tularensis SCHU S4 zinc-binding domain-containing protein YP_169245.1 200305 D 177416 CDS YP_169246.1 56707350 3191505 200770..201660 1 NC_006570.2 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 201660 ddlB 3191505 ddlB Francisella tularensis subsp. tularensis SCHU S4 D-alanyl-alanine synthetase A YP_169246.1 200770 D 177416 CDS YP_169247.1 56707351 3192466 201657..202340 1 NC_006570.2 Similar to Q83F15 Cell division protein FtsQ from Coxiella burnetii (243 aa). FASTA: opt: 291 Z-score: 355.4 E(): 6.6e-12 Smith-Waterman score: 291; 23.176 identity in 233 aa overlap; cell division protein FtsQ 202340 ftsQ 3192466 ftsQ Francisella tularensis subsp. tularensis SCHU S4 cell division protein FtsQ YP_169247.1 201657 D 177416 CDS YP_169248.1 56707352 3191833 202442..203704 1 NC_006570.2 Similar to Q87WY9 Cell division protein FtsA from Pseuodomonas syringae (418 aa). FASTA: opt: 992 Z-score: 1194.6 E(): 1.2e-58 Smith-Waterman score: 992; 37.621 identity in 412 aa overlap; cell division protein FtsA 203704 ftsA 3191833 ftsA Francisella tularensis subsp. tularensis SCHU S4 cell division protein FtsA YP_169248.1 202442 D 177416 CDS YP_169249.1 56707353 3191126 203748..204893 1 NC_006570.2 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 204893 ftsZ 3191126 ftsZ Francisella tularensis subsp. tularensis SCHU S4 cell division protein FtsZ YP_169249.1 203748 D 177416 CDS YP_169250.1 56707354 3190839 204916..205776 1 NC_006570.2 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 205776 lpxC 3190839 lpxC Francisella tularensis subsp. tularensis SCHU S4 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_169250.1 204916 D 177416 CDS YP_169251.1 56707355 3191541 complement(205790..207430) 1 NC_006570.2 Similar to Q8DB24 DNA polymerase III, gamma/tau subunits from Vibrio vulnificus (734 aa). FASTA: opt: 1193 Z-score: 1334.5 E(): 1.9e-66 Smith-Waterman score: 1193; 44.893 identity in 421 aa overlap; DNA polymerase III subunit gamma and tau 207430 dnaX 3191541 dnaX Francisella tularensis subsp. tularensis SCHU S4 DNA polymerase III subunit gamma and tau YP_169251.1 205790 R 177416 CDS YP_169252.1 56707356 3191240 207703..208680 1 NC_006570.2 Similar to RF2_HAEIN (P43918) Peptide chain release factor 2 from Haemophilus influenzae (365 aa). FASTA: opt: 1542 Z-score: 1839.9 E(): 1.4e-94 Smith-Waterman score: 1542; 68.405 identity in 326 aa overlap; peptide chain release factor 2 208680 prfB 3191240 prfB Francisella tularensis subsp. tularensis SCHU S4 peptide chain release factor 2 YP_169252.1 207703 D 177416 CDS YP_169253.1 56707357 3190947 208813..210543 1 NC_006570.2 Similar to SYK2_ECOLI (P14825) Lysyl-tRNA synthetase, heat inducible, from E. coli (504 aa). FASTA: opt: 2003 Z-score: 2242.9 E(): 4.9e-117 Smith-Waterman score: 2003; 61.066 identity in 488 aa overlap; lysyl-tRNA synthetase 210543 lysU 3190947 lysU Francisella tularensis subsp. tularensis SCHU S4 lysyl-tRNA synthetase YP_169253.1 208813 D 177416 CDS YP_169254.1 56707358 3191362 complement(210928..211470) 1 NC_006570.2 Similar to Y208_VIBCH (Q9KVD8) Hypothetical protein VC0208 from Vibrio cholerae (162 aa). FASTA: opt: 414 Z-score: 528.5 E(): 1.5e-21 Smith-Waterman score: 414; 41.875 identity in 160 aa overlap ORF ftt0193c; hypothetical protein 211470 3191362 FTT_0193c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169254.1 210928 R 177416 CDS YP_169255.1 56707359 3191359 complement(211569..212441) 1 NC_006570.2 Similar to Q8X898 Hypothetical 31.1 kDa protein (Hypothetical membrane protein) from E.coli (274 aa). FASTA: opt: 398 Z-score: 431.1 E(): 4e-16 Smith-Waterman score: 398; 26.429 identity in 280 aa overlap ORF ftt0194c; hypothetical protein 212441 3191359 FTT_0194c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169255.1 211569 R 177416 CDS YP_169256.1 56707360 3191355 complement(212450..213991) 1 NC_006570.2 Similar to Q8IX91 L-glutaminase from Homo sapien (602 aa). FASTA: opt: 1441 Z-score: 1670.0 E(): 3.9e-85 Smith-Waterman score: 1441; 42.887 identity in 478 aa overlap ORF ftt0195c; L-glutamine synthetase 213991 3191355 FTT_0195c Francisella tularensis subsp. tularensis SCHU S4 L-glutamine synthetase YP_169256.1 212450 R 177416 CDS YP_169257.1 56707361 3191892 complement(214073..215110) 1 NC_006570.2 Similar to AAO90051 (Q83E31) Glutamine synthetase from Coxiella burnetti (359 aa). FASTA: opt: 1369 Z-score: 1705.1 E(): 4.4e-87 Smith-Waterman score: 1369; 59.226 identity in 336 aa overlap; glutamine synthetase 215110 glnA 3191892 glnA Francisella tularensis subsp. tularensis SCHU S4 glutamine synthetase YP_169257.1 214073 R 177416 CDS YP_169258.1 56707362 3192432 complement(215230..216207) 1 NC_006570.2 Similar to Q88DM9 DNA polymerase III, delta subunit from Pseudomonas putida (345 aa). FASTA: opt: 380 Z-score: 451.8 E(): 2.8e-17 Smith-Waterman score: 380; 28.707 identity in 317 aa overlap; DNA polymerase III subunit delta 216207 holA 3192432 holA Francisella tularensis subsp. tularensis SCHU S4 DNA polymerase III subunit delta YP_169258.1 215230 R 177416 CDS YP_169259.1 56707363 3192374 216335..216811 1 NC_006570.2 Similar to Q8EGB4 Lipoprotein Blc from Shewenella oneidensis (177 aa). FASTA: opt: 620 Z-score: 813.1 E(): 2.1e-37 Smith-Waterman score: 620; 56.604 identity in 159 aa overlap; outer membrane lipoprotein 216811 blc 3192374 blc Francisella tularensis subsp. tularensis SCHU S4 outer membrane lipoprotein YP_169259.1 216335 D 177416 CDS YP_169262.1 56707366 3191805 complement(218947..219690) 1 NC_006570.2 ISFtu2. Transposase, member of the IS5 family. Identical to Q8GM03 transposase from Francisella tularensis (247 aa).; transposase 219690 isftu2 3191805 isftu2 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169262.1 218947 R 177416 CDS YP_169263.1 56707367 3191667 complement(220941..222488) 1 NC_006570.2 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 222488 purH 3191667 purH Francisella tularensis subsp. tularensis SCHU S4 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_169263.1 220941 R 177416 CDS YP_169264.1 56707368 3192003 222665..223951 1 NC_006570.2 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 223951 purA 3192003 purA Francisella tularensis subsp. tularensis SCHU S4 adenylosuccinate synthetase YP_169264.1 222665 D 177416 CDS YP_169265.1 56707369 3192107 223955..224488 1 NC_006570.2 Similar to Q8R7L0 Hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcogenesis (181 aa). FASTA: opt: 509 Z-score: 658.7 E(): 8.5e-29 Smith-Waterman score: 509; 47.337 identity in 169 aa overlap; hypoxanthine-guanine phosphoribosyltransferase 224488 hpt 3192107 hpt Francisella tularensis subsp. tularensis SCHU S4 hypoxanthine-guanine phosphoribosyltransferase YP_169265.1 223955 D 177416 CDS YP_169266.1 56707370 3191352 complement(225323..226165) 1 NC_006570.2 Similar to Q8G5L3 Possible permease of ABC transporter system from Bifidobacterium longum (277 aa). FASTA: opt: 582 Z-score: 622.6 E(): 8.7e-27 Smith-Waterman score: 582; 38.372identity in 258 aa overlap ORF ftt0207c; ABC transporter permease 226165 3191352 FTT_0207c Francisella tularensis subsp. tularensis SCHU S4 ABC transporter permease YP_169266.1 225323 R 177416 CDS YP_169267.1 56707371 3191351 complement(226107..226784) 1 NC_006570.2 Similar to MNTB_BACSU (O34338) Manganese transport system ATP-binding protein mntB from Bacillus subtilis (250 aa). FASTA: opt: 365 Z-score: 426.7 E(): 7.1e-16 Smith-Waterman score: 365; 30.986 identity in 213 aa overlap ORF ftt0208c; ABC transporter ATP-binding protein 226784 3191351 FTT_0208c Francisella tularensis subsp. tularensis SCHU S4 ABC transporter ATP-binding protein YP_169267.1 226107 R 177416 CDS YP_169268.1 56707372 3191350 complement(226786..227703) 1 NC_006570.2 Similar to Q88TE8 ABC transporter substrate binding protein from Lactobacillus plantarum (297 aa). FASTA: opt: 555 Z-score: 628.8 E(): 3.9e-27 Smith-Waterman score: 555; 30.935identity in 278 aa overlap ORF ftt0209c; periplasmic solute binding family protein 227703 3191350 FTT_0209c Francisella tularensis subsp. tularensis SCHU S4 periplasmic solute binding family protein YP_169268.1 226786 R 177416 CDS YP_169269.1 56707373 3191348 complement(229119..229583) 1 NC_006570.2 Similar to Q9F6B1 Outer membrane lipoprotein Pcp from Edwardsiella tarda (155 aa). FASTA: opt: 294 Z-score: 329.0 E(): 2e-10 Smith-Waterman score: 294; 35.032 identity in 157 aa overlap ORF ftt0211c; outer membrane lipoprotein 229583 3191348 FTT_0211c Francisella tularensis subsp. tularensis SCHU S4 outer membrane lipoprotein YP_169269.1 229119 R 177416 CDS YP_169270.1 56707374 3192104 complement(229594..230190) 1 NC_006570.2 Similar to Q9I509 Trp repressor binding protein WrbA from Pseudomonas aeruginosa (198 aa). FASTA: opt: 727 Z-score: 948.0 E(): 6.5e-45 Smith-Waterman score: 727; 54.974 identity in 191 aa overlap; trp repressor binding protein 230190 wrbA 3192104 wrbA Francisella tularensis subsp. tularensis SCHU S4 trp repressor binding protein YP_169270.1 229594 R 177416 CDS YP_169271.1 56707375 3191645 230197..231384 1 NC_006570.2 Similar to RBN_ECOLI (P32146) tRNA processing ribonuclease BN from E. coli (290 aa). FASTA: opt: 535 Z-score: 578.5 E(): 2.5e-24 Smith-Waterman score: 535; 33.813 identity in 278 aa overlap; tRNA processing ribonuclease BN 231384 rbn 3191645 rbn Francisella tularensis subsp. tularensis SCHU S4 tRNA processing ribonuclease BN YP_169271.1 230197 D 177416 CDS YP_169272.1 56707376 3191237 231974..234127 1 NC_006570.2 Similar to Q9KNQ3 Primosomal protein N` from Vibrio cholerae (734 aa). FASTA: opt: 1587 Z-score: 1770.8 E(): 9.7e-91 Smith-Waterman score: 1619; 37.823 identity in 735 aa overlap; primosomal protein N' 234127 priA 3191237 priA Francisella tularensis subsp. tularensis SCHU S4 primosomal protein N' YP_169272.1 231974 D 177416 CDS YP_169273.1 56707377 3191113 join(234257..234583,234583..235041) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 235041 isftu1 3191113 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169273.1 234257 D 177416 CDS YP_169274.1 56707378 3191345 complement(235980..236975) 1 NC_006570.2 Similar to Q81FW2 Low-affinity inorganic phosphate transport protein from Bacillus cereus (332 aa). FASTA: opt: 932 Z-score: 1065.7 E(): 1.8e-51 Smith-Waterman score: 932; 42.470 identity in 332 aa overlap ORF ftt0219c; phosphate transport protein 236975 3191345 FTT_0219c Francisella tularensis subsp. tularensis SCHU S4 phosphate transport protein YP_169274.1 235980 R 177416 CDS YP_169275.1 56707379 3191343 complement(236993..237649) 1 NC_006570.2 Similar to Q8XMV6 Hypothetical protein CPE0582 from Clostridium perfringens (210 aa). FASTA: opt: 207 Z-score: 248.6 E(): 5.9e-06 Smith-Waterman score: 207; 24.883 identity in 213 aa overlap ORF ftt0220c; hypothetical protein 237649 3191343 FTT_0220c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169275.1 236993 R 177416 CDS YP_169276.1 56707380 3192410 237886..239430 1 NC_006570.2 acid phosphatase 239430 acpA 3192410 acpA Francisella tularensis subsp. tularensis SCHU S4 acid phosphatase YP_169276.1 237886 D 177416 CDS YP_169277.1 56707381 3192142 complement(239437..240213) 1 NC_006570.2 Similar to YBGK_HAEIN (P44298) Hypothetical protein HI1730 from Haemophilus influenzae (309 aa). FASTA: opt: 308 Z-score: 386.7 E(): 1.2e-13 Smith-Waterman score: 352; 32.453 identity in 265 aa overlap; hydrolase subunit 240213 ybgK 3192142 ybgK Francisella tularensis subsp. tularensis SCHU S4 hydrolase subunit YP_169277.1 239437 R 177416 CDS YP_169278.1 56707382 3192131 complement(240255..240953) 1 NC_006570.2 Similar to Y993_PYRAB (Q9V005) Hypothetical UPF0271 protein PYRAB09930 from Pyrococcus abyssi (255 aa). FASTA: opt: 430 Z-score: 541.0 E(): 3e-22 Smith-Waterman score: 430; 35.294 identity in 238 aa overlap; LamB/YcsF family protein 240953 ybgL 3192131 ybgL Francisella tularensis subsp. tularensis SCHU S4 LamB/YcsF family protein YP_169278.1 240255 R 177416 CDS YP_169279.1 56707383 3191787 complement(join(242738..243196,243196..243522)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 243522 isftu1 3191787 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169279.1 242738 R 177416 CDS YP_169280.1 56707384 3191340 complement(243546..243740) 1 NC_006570.2 ORF ftt0227c; hypothetical protein 243740 3191340 FTT_0227c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169280.1 243546 R 177416 CDS YP_169281.1 56707385 3191187 complement(243775..244311) 1 NC_006570.2 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 244311 orn 3191187 orn Francisella tularensis subsp. tularensis SCHU S4 oligoribonuclease YP_169281.1 243775 R 177416 CDS YP_169282.1 56707386 3191555 complement(244314..244883) 1 NC_006570.2 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 244883 efp 3191555 efp Francisella tularensis subsp. tularensis SCHU S4 elongation factor P YP_169282.1 244314 R 177416 CDS YP_169283.1 56707387 3191339 complement(244923..245330) 1 NC_006570.2 Similar to Q87B50 Type IV pilin from Xylella fastidiosa (142 aa). FASTA: opt: 224 Z-score: 300.3 E(): 7.8e-09 Smith-Waterman score: 224; 32.090 identity in 134 aa overlap The pili fiber building block protein has a highly distinct primary structure; a short positively charged leader sequence, and a highly conserved and highly hydrophobic amino-terminal domain which forms the core of the pilus fiber; A variety of studies suggest that the invariant glycine (G) at -1 is required for prepilin cleavage and assembly and that the glutamate (E) at + 5 is essential for assembly and efficient N-terminal methylation but not cleavage. The region near the carboxy terminus is often hydrophilic and is stabilized by one or two disulfide bridges that may be involved in recognition of receptors. The genes with these characteristics are usually termed pilA, pilE, pilV, pilW, pilX and FimU. (Mattick John S.. 'Type IV Pili and twitching motility'. Annu. Rev. Microbiol. 2002. 56:289-314.) This protein has all the characteristics described above. ORF ftt0230c; Type IV pili fiber building block protein 245330 3191339 FTT_0230c Francisella tularensis subsp. tularensis SCHU S4 Type IV pili fiber building block protein YP_169283.1 244923 R 177416 CDS YP_169284.1 56707388 3191968 complement(245343..246266) 1 NC_006570.2 Similar to HTRB_ECOLI (P24187) Lipid A biosynthesis lauroyl acyltransferase from E. coli (306 aa). FASTA: opt: 542 Z-score: 697.7 E(): 5.7e-31 Smith-Waterman score: 542; 32.895 identity in 304 aa overlap (8-307:14-306) n.b.Paralog of FTT0232c; acyltransferase 246266 htrB 3191968 htrB Francisella tularensis subsp. tularensis SCHU S4 acyltransferase YP_169284.1 245343 R 177416 CDS YP_169285.1 56707389 3191506 complement(246327..247226) 1 NC_006570.2 Similar to Q8ZNA3 (Q8ZNA3) Cold shock-induced palmitoleoyl transferase from Salmonella typhimurium (306 aa). FASTA: opt: 629 Z-score: 782.5 E(): 1.1e-35 Smith-Waterman score: 629; 36.755 identity in 302 aa overlap Paralog of FTT0231c; acyltransferase 247226 ddg 3191506 ddg Francisella tularensis subsp. tularensis SCHU S4 acyltransferase YP_169285.1 246327 R 177416 CDS YP_169286.1 56707390 3191276 complement(247233..248888) 1 NC_006570.2 Similar to 60IM_COXBU (P45650) 60 kDa inner-membrane protein homolog from Coxiella burnetti (566 aa). FASTA: opt: 1434 Z-score: 1537.8 E(): 8.4e-78 Smith-Waterman score: 1434; 41.815 identity in 562 aa overlap; inner-membrane protein 248888 yidC 3191276 yidC Francisella tularensis subsp. tularensis SCHU S4 inner-membrane protein YP_169286.1 247233 R 177416 CDS YP_169287.2 537470112 3191338 complement(248897..249169) 1 NC_006570.2 hypothetical protein 249169 3191338 FTT_0234c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169287.2 248897 R 177416 CDS YP_169288.1 56707392 3191068 complement(249121..249522) 1 NC_006570.2 Similar to RNPA_VIBCH (Q9KVY2) Ribonuclease P protein component from Vibrio cholerae (118 aa). FASTA: opt: 189 Z-score: 256.8 E(): 2.1e-06 Smith-Waterman score: 189; 35.870 identity in 92 aa overlap; ribonuclease P protein component 249522 rnpA 3191068 rnpA Francisella tularensis subsp. tularensis SCHU S4 ribonuclease P protein component YP_169288.1 249121 R 177416 CDS YP_169289.1 56707393 3191988 complement(249464..249598) 1 NC_006570.2 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 249598 rpmH 3191988 rpmH Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L34 YP_169289.1 249464 R 177416 CDS YP_169290.1 56707394 3191337 complement(249690..250148) 1 NC_006570.2 ORF ftt0237c; hypothetical protein 250148 3191337 FTT_0237c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169290.1 249690 R 177416 CDS YP_169291.1 56707395 3190948 250275..251048 1 NC_006570.2 Similar to AROE_VIBVU (Q8DDD4) Shikimate 5-dehydrogenase from Vibrio vulnificus (277 aa). FASTA: opt: 567 Z-score: 672.1 E(): 1.5e-29 Smith-Waterman score: 567; 37.984 identity in 258 aa overlap; shikimate 5-dehydrogenase 251048 aroE1 3190948 aroE1 Francisella tularensis subsp. tularensis SCHU S4 shikimate 5-dehydrogenase YP_169291.1 250275 D 177416 CDS YP_169292.1 56707396 3191258 251115..252470 1 NC_006570.2 Similar to Q9F1M9 MurC from Shewanella violacae (494 aa). FASTA: opt: 1010 Z-score: 1212.3 E(): 1.2e-59 Smith-Waterman score: 1010; 36.761 identity in 457 aa overlap; UDP-N-acetylmuramate--L-alanine ligase 252470 murC 3191258 murC Francisella tularensis subsp. tularensis SCHU S4 UDP-N-acetylmuramate--L-alanine ligase YP_169292.1 251115 D 177416 CDS YP_169293.1 56707397 3191336 252463..253335 1 NC_006570.2 Similar to Q87SH3 Conserved hypothetical protein from Vibrio parahaemolyticus (287 aa). FASTA: opt: 744 Z-score: 882.7 E(): 2.8e-41 Smith-Waterman score: 744; 46.996 identity in 283 aa overlap ORF ftt0240; tetrapyrrole methyltransferase family protein 253335 3191336 FTT_0240 Francisella tularensis subsp. tularensis SCHU S4 tetrapyrrole methyltransferase family protein YP_169293.1 252463 D 177416 CDS YP_169294.1 56707398 3191333 complement(253346..253816) 1 NC_006570.2 ORF ftt0241c; hypothetical protein 253816 3191333 FTT_0241c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169294.1 253346 R 177416 CDS YP_169295.1 56707399 3191334 254156..254719 1 NC_006570.2 Similar to Q83DS9 Hypothetical protein CBU0616 from Coxiella burnetii (196 aa). FASTA: opt: 376 Z-score: 484.1 E(): 4.5e-19 Smith-Waterman score: 376; 37.634 identity in 186 aa overlap ORF ftt0242; hypothetical protein 254719 3191334 FTT_0242 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169295.1 254156 D 177416 CDS YP_169296.1 56707400 3191331 254792..255571 1 NC_006570.2 weak similarity to M. musculus protein,1700056O17 Rik protein (233 aa) ORF ftt0243; hypothetical protein 255571 3191331 FTT_0243 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169296.1 254792 D 177416 CDS YP_169297.1 56707401 3191332 255555..258296 1 NC_006570.2 Similar to Q8R5Z3 DNA/RNA helicase (DEAD/DEAH box family) from Fusobacterium nucleatum (942 aa). FASTA: opt: 2318 Z-score: 2654.5 E(): 5.8e-140 Smith-Waterman score: 2473; 45.087 identity in 916 aa overlap ORF ftt0244; DNA/RNA helicase 258296 3191332 FTT_0244 Francisella tularensis subsp. tularensis SCHU S4 DNA/RNA helicase YP_169297.1 255555 D 177416 CDS YP_169298.1 56707402 3191912 258372..259208 1 NC_006570.2 Similar to Q8PWX4 Universal stress protein from Methanosarcina maizae (323 aa). FASTA: opt: 347 Z-score: 418.2 E(): 2.1e-15 Smith-Waterman score: 347; 31.849 identity in 292 aa overlap; universal stress protein 259208 usp 3191912 usp Francisella tularensis subsp. tularensis SCHU S4 universal stress protein YP_169298.1 258372 D 177416 CDS YP_169299.1 56707403 3190734 join(259568..259894,259894..260352) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 260352 isftu1 3190734 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169299.1 259568 D 177416 CDS YP_169300.1 56707404 3191328 260522..260893 1 NC_006570.2 ORF ftt0248; hypothetical protein 260893 3191328 FTT_0248 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169300.1 260522 D 177416 CDS YP_169301.1 56707405 3191885 260994..263237 1 NC_006570.2 Similar to Q8ZJH5 Ferrous iron transport protein B from Yersinia pestis (771 aa). FASTA: opt: 1928 Z-score: 2034.7 E(): 1.9e-105 Smith-Waterman score: 2307; 45.396 identity in 771 aa overlap; ferrous iron transport protein 263237 feoB 3191885 feoB Francisella tularensis subsp. tularensis SCHU S4 ferrous iron transport protein YP_169301.1 260994 D 177416 CDS YP_169302.1 56707406 3191412 264049..266697 1 NC_006570.2 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 266697 ppdK 3191412 ppdK Francisella tularensis subsp. tularensis SCHU S4 pyruvate phosphate dikinase YP_169302.1 264049 D 177416 CDS YP_169303.1 56707407 3191569 267097..267984 1 NC_006570.2 Similar to Q8Y1X0 Probable branched-chain amino acid aminotransferase protein from Ralstonia solanacearum (309 aa). FASTA: opt: 706 Z-score: 903.1 E(): 2.1e-42 Smith-Waterman score: 706; 39.931 identity in 288 aa overlap; branched-chain amino acid aminotransferase 267984 ilvE 3191569 ilvE Francisella tularensis subsp. tularensis SCHU S4 branched-chain amino acid aminotransferase YP_169303.1 267097 D 177416 CDS YP_169304.1 56707408 3190775 267995..269368 1 NC_006570.2 Similar to Q9C5X5 2-isopropylmalate synthase from Arabidopsis thaliana (503 aa). FASTA: opt: 493 Z-score: 601.2 E(): 1.4e-25 Smith-Waterman score: 635; 31.373 identity in 408 aa overlap. This CDS is disrupted by the insertion of an ISFtu1 element occurring very near the C-terminal end. It is not clear whether this insertion affects the function of the protein; 2-isopropylmalate synthase 269368 leuA 3190775 leuA Francisella tularensis subsp. tularensis SCHU S4 2-isopropylmalate synthase YP_169304.1 267995 D 177416 CDS YP_169305.1 56707409 3191118 complement(join(269465..269923,269923..270249)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 270249 isftu1 3191118 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169305.1 269465 R 177416 CDS YP_169308.1 56707412 3191322 complement(272034..273002) 1 NC_006570.2 Similar to Q87T79 lipopolysaccharide A protein from Vibrio parahaemolyticus (311 aa). FASTA: opt: 835 Z-score: 996.3 E(): 1.3e-47 Smith-Waterman score: 910; 43.671 identity in 316 aa overlap ORF ftt0256c; lipopolysaccharide protein 273002 3191322 FTT_0256c Francisella tularensis subsp. tularensis SCHU S4 lipopolysaccharide protein YP_169308.1 272034 R 177416 CDS YP_169309.1 56707413 3191323 273191..275047 1 NC_006570.2 Similar to Q8YNW1 Ribonuclease II family protein from Anabaena sp. (686 aa). FASTA: opt: 557 Z-score: 649.1 E(): 2.9e-28 Smith-Waterman score: 763; 28.290 identity in 661 aa overlap ORF ftt0257; ribonuclease II family protein 275047 3191323 FTT_0257 Francisella tularensis subsp. tularensis SCHU S4 ribonuclease II family protein YP_169309.1 273191 D 177416 CDS YP_169310.1 56707414 3191320 275378..276046 1 NC_006570.2 Similar to Q83AC9 Carboxylesterase/phospholipase family protein from Coxiella burnetii (200 aa). FASTA: opt: 599 Z-score: 736.0 E(): 4.2e-33 Smith-Waterman score: 599; 45.813 identity in 203 aa overlap ORF ftt0258; carboxylesterase/phospholipase family protein 276046 3191320 FTT_0258 Francisella tularensis subsp. tularensis SCHU S4 carboxylesterase/phospholipase family protein YP_169310.1 275378 D 177416 CDS YP_169311.1 56707415 3192416 276043..276945 1 NC_006570.2 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 276945 hemC 3192416 hemC Francisella tularensis subsp. tularensis SCHU S4 porphobilinogen deaminase YP_169311.1 276043 D 177416 CDS YP_169312.1 56707416 3191891 276946..277338 1 NC_006570.2 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 277338 crcB 3191891 crcB Francisella tularensis subsp. tularensis SCHU S4 camphor resistance protein CrcB YP_169312.1 276946 D 177416 CDS YP_169313.1 56707417 3191319 277335..277742 1 NC_006570.2 The predicted signal peptide are in conflict with the membrane lipoprotein lipid attachment site ORF ftt0261; hypothetical protein 277742 3191319 FTT_0261 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169313.1 277335 D 177416 CDS YP_169314.1 56707418 3191318 277882..278019 1 NC_006570.2 The predicted signal peptide and the membrane lipoprotein lipid attachment site are in conflict with each other ORF ftt0262; lipoprotein 278019 3191318 FTT_0262 Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_169314.1 277882 D 177416 CDS YP_169316.1 56707420 3191308 complement(278449..278622) 1 NC_006570.2 Similar to Q8Y1X1 Hypothetical protein RSc0566 from Ralstonia solancearum (65 aa). FASTA: opt: 160 Z-score: 236.6 E(): 2.5e-05 Smith-Waterman score: 160; 50.000 identity in 36 aa overlap ORF ftt0264c; hypothetical protein 278622 3191308 FTT_0264c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169316.1 278449 R 177416 CDS YP_169317.1 56707421 3191316 278751..280550 1 NC_006570.2 Similar to Q83AV7 ABC transporter,permease protein from Coxiella burnetii (581 aa). FASTA: opt: 976 Z-score: 1115.9 E(): 2.9e-54 Smith-Waterman score: 1738; 45.318 identity in 598 aa overlap ORF ftt0265; ABC transporter permease 280550 3191316 FTT_0265 Francisella tularensis subsp. tularensis SCHU S4 ABC transporter permease YP_169317.1 278751 D 177416 CDS YP_169318.1 56707422 3191315 280569..281885 1 NC_006570.2 Similar to Q83AV8 ABC transporter, ATP-binding protein from Coxiella burnetii (432 aa). FASTA: opt: 1556 Z-score: 1713.5 E(): 1.5e-87 Smith-Waterman score: 1556; 54.673 identity in 428 aa overlap ORF ftt0266; ABC transporter ATP-binding protein 281885 3191315 FTT_0266 Francisella tularensis subsp. tularensis SCHU S4 ABC transporter ATP-binding protein YP_169318.1 280569 D 177416 CDS YP_169319.1 56707423 3191314 282010..283128 1 NC_006570.2 ORF ftt0267; hypothetical protein 283128 3191314 FTT_0267 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169319.1 282010 D 177416 CDS YP_169320.1 56707424 3191312 283222..285108 1 NC_006570.2 Similar to Q88MV1 Sodium/hydrogen exchanger family protein from Pseudomonas putida (601 aa). FASTA: opt: 1318 Z-score: 1419.4 E(): 3.6e-71 Smith-Waterman score: 1318; 37.993 identity in 608 aa overlap ORF ftt0268; sodium/hydrogen exchanger (antiporter) family protein 285108 3191312 FTT_0268 Francisella tularensis subsp. tularensis SCHU S4 sodium/hydrogen exchanger (antiporter) family protein YP_169320.1 283222 D 177416 CDS YP_169321.1 56707425 3191311 285093..285632 1 NC_006570.2 Similar to Q8EKP8 Carbonic anhydrase,family 3 from Shewanella oneidensis (182 aa). FASTA: opt: 639 Z-score: 840.8 E(): 6.1e-39 Smith-Waterman score: 639; 50.000 identity in 178 aa overlap ORF ftt0269; carbonic anhydrase 285632 3191311 FTT_0269 Francisella tularensis subsp. tularensis SCHU S4 carbonic anhydrase YP_169321.1 285093 D 177416 CDS YP_169322.1 56707426 3191459 285583..286218 1 NC_006570.2 Similar to Q83AQ2 Outer membrane lipoprotein LolB, from Coxiella burnetii (210 aa). FASTA: opt: 395 Z-score: 508.7 E(): 1.9e-20 Smith-Waterman score: 395; 33.668 identity in 199 aa overlap; lipoprotein releasing system outer membrane lipoprotein 286218 lolB 3191459 lolB Francisella tularensis subsp. tularensis SCHU S4 lipoprotein releasing system outer membrane lipoprotein YP_169322.1 285583 D 177416 CDS YP_169323.1 56707427 3190842 286206..287033 1 NC_006570.2 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 287033 ipk 3190842 ipk Francisella tularensis subsp. tularensis SCHU S4 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_169323.1 286206 D 177416 CDS YP_169324.1 56707428 3191309 287222..287542 1 NC_006570.2 ORF ftt0272; hypothetical protein 287542 3191309 FTT_0272 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169324.1 287222 D 177416 CDS YP_169325.1 56707429 3191277 join(287566..287892,287892..288350) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 288350 isftu1 3191277 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169325.1 287566 D 177416 CDS YP_169327.1 56707431 3191304 complement(290427..290525) 1 NC_006570.2 Similar to Q937K9 YbgT protein from Erwinia chrysanthemi (38 aa). FASTA: opt: 81 Z-score: 153.9 E(): 1 Smith-Waterman score: 81; 42.857 identity in 28 aa overlap ORF ftt0277c; hypothetical protein 290525 3191304 FTT_0277c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169327.1 290427 R 177416 CDS YP_169328.1 56707432 3191907 complement(290541..291734) 1 NC_006570.2 Similar to AAO69749 (Q8XGM0) Cytochrome d ubiquinol oxidase subunit II from Salmonella typhi (379 aa). FASTA: opt: 645 Z-score: 711.2 E(): 1e-31 Smith-Waterman score: 1022; 40.506identity in 395 aa overlap; cytochrome d terminal oxidase polypeptide subunit II 291734 cydB 3191907 cydB Francisella tularensis subsp. tularensis SCHU S4 cytochrome d terminal oxidase polypeptide subunit II YP_169328.1 290541 R 177416 CDS YP_169329.1 56707433 3191902 complement(291745..293523) 1 NC_006570.2 Similar to AAP96534 (Q7VKT6) Cytochrome D ubiquinol oxidase, subunit I from Haemophilus ducreyi (516 aa). FASTA: opt: 1311 Z-score: 1457.7 E(): 2.7e-73 Smith-Waterman score: 1688; 47.478identity in 575 aa overlap Schu S4 seems to have extra sequence in between 340-420 aa; cytochrome d terminal oxidase polypeptide subunit I 293523 cydA 3191902 cydA Francisella tularensis subsp. tularensis SCHU S4 cytochrome d terminal oxidase polypeptide subunit I YP_169329.1 291745 R 177416 CDS YP_169330.1 56707434 3192130 complement(293952..295319) 1 NC_006570.2 Similar to AAO89830 (Q83EP3) Major facilitator family transporter from Coxiella burnetii (458 aa). FASTA: opt: 1379 Z-score: 1410.6 E(): 1.1e-70 Smith-Waterman score: 1379; 46.102 identity in 449 aa overlap; major facilitator transporter 295319 yajR 3192130 yajR Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_169330.1 293952 R 177416 CDS YP_169331.1 56707435 3191910 295680..296582 1 NC_006570.2 Similar to Q87DQ7 Cytochrome O ubiquinol oxidase subunit II from Xylella fastidiosa (319 aa). FASTA: opt: 956 Z-score: 1145.6 E(): 6.4e-56 Smith-Waterman score: 956; 49.477 identity in 287 aa overlap; cytochrome O ubiquinol oxidase subunit II 296582 cyoA 3191910 cyoA Francisella tularensis subsp. tularensis SCHU S4 cytochrome O ubiquinol oxidase subunit II YP_169331.1 295680 D 177416 CDS YP_169332.1 56707436 3191917 296621..298651 1 NC_006570.2 Similar to AAO70008 (Q8XG02) Cytochrome o ubiquinol oxidase subunit I from Salmonella typhi (663 aa). FASTA: opt: 3045 Z-score: 3221.2 E(): 1.6e-171 Smith-Waterman score: 3045; 64.361identity in 665 aa overlap; cytochrome O ubiquinol oxidase subunit I 298651 cyoB 3191917 cyoB Francisella tularensis subsp. tularensis SCHU S4 cytochrome O ubiquinol oxidase subunit I YP_169332.1 296621 D 177416 CDS YP_169333.1 56707437 3191921 298648..299250 1 NC_006570.2 Similar to Q87IH7 Cytochrome o ubiquinol oxidase, subunit III from Vibrio parahaemolyticus (200 aa). FASTA: opt: 768 Z-score: 931.9 E(): 5.1e-44 Smith-Waterman score: 768; 55.276identity in 199 aa overlap; cytochrome O ubiquinol oxidase subunit III 299250 cyoC 3191921 cyoC Francisella tularensis subsp. tularensis SCHU S4 cytochrome O ubiquinol oxidase subunit III YP_169333.1 298648 D 177416 CDS YP_169334.1 56707438 3191924 299252..299584 1 NC_006570.2 Similar to Q8ZC55 Cytochrome O ubiquinol oxidase subunit IV from Yersinia pestis (110 aa). FASTA: opt: 325 Z-score: 419.7 E(): 1.7e-15 Smith-Waterman score: 325; 50.505 identity in 99 aa overlap; cytochrome O ubiquinol oxidase subunit IV 299584 cyoD 3191924 cyoD Francisella tularensis subsp. tularensis SCHU S4 cytochrome O ubiquinol oxidase subunit IV YP_169334.1 299252 D 177416 CDS YP_169335.1 56707439 3192388 299615..300463 1 NC_006570.2 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 300463 cyoE 3192388 cyoE Francisella tularensis subsp. tularensis SCHU S4 protoheme IX farnesyltransferase YP_169335.1 299615 D 177416 CDS YP_169336.1 56707440 3190871 complement(300608..301651) 1 NC_006570.2 Similar to Q8A014 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase from Bacteroides thetaiotaomicron (346 aa). FASTA: opt: 687 Z-score: 795.8 E(): 2e-36 Smith-Waterman score: 687; 33.431 identity in 341 aa overlap paralog of FTT1571; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 301651 lpxD2 3190871 lpxD2 Francisella tularensis subsp. tularensis SCHU S4 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_169336.1 300608 R 177416 CDS YP_169337.1 56707441 3191302 complement(301719..302414) 1 NC_006570.2 Similar to Q8XIW2 Hypothetical protein CPE2001 from Clostridium perfringens (229 aa). FASTA: opt: 806 Z-score: 994.2 E(): 1.7e-47 Smith-Waterman score: 806; 51.948 identity in 231 aa overlap ORF ftt0287c; hypothetical protein 302414 3191302 FTT_0287c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169337.1 301719 R 177416 CDS YP_169338.1 56707442 3191321 complement(302414..303265) 1 NC_006570.2 Similar to Q8D4Q2 Pyridoxal/pyridoxine/pyridoxamine kinase from Vibrio vulnificus (290 aa). FASTA: opt: 611 Z-score: 766.0 E(): 8.9e-35 Smith-Waterman score: 611; 38.545identity in 275 aa overlap; pyridoxal kinase 303265 pdxY 3191321 pdxY Francisella tularensis subsp. tularensis SCHU S4 pyridoxal kinase YP_169338.1 302414 R 177416 CDS YP_169339.1 56707443 3191300 complement(303272..303706) 1 NC_006570.2 ORF ftt0289c; hypothetical protein 303706 3191300 FTT_0289c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169339.1 303272 R 177416 CDS YP_169340.1 56707444 3192009 303852..304808 1 NC_006570.2 Similar to Q87YN6 MoxR protein, , from Pseudomonas syringae (319 aa). FASTA: opt: 1309 Z-score: 1518.5 E(): 9.9e-77 Smith-Waterman score: 1309; 61.489 identity in 309 aa overlap; methanol dehydrogenase regulatory protein 304808 moxR 3192009 moxR Francisella tularensis subsp. tularensis SCHU S4 methanol dehydrogenase regulatory protein YP_169340.1 303852 D 177416 CDS YP_169341.1 56707445 3191299 304821..305732 1 NC_006570.2 Similar to Q87YN5 Conserved hypothetical protein from Pseudomonas syringae (314 aa). FASTA: opt: 561 Z-score: 693.3 bits: 136.4 E(): 1e-30 Smith-Waterman score: 561; 30.479 identity in 292 aa overlap ORF ftt0291; hypothetical protein 305732 3191299 FTT_0291 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169341.1 304821 D 177416 CDS YP_169342.1 56707446 3191297 305722..306198 1 NC_006570.2 Similar to Q8D3W9 Conserved hypothetical protein from Vibrio vulnificus (156 aa). FASTA: opt: 228 Z-score: 276.8 E(): 1.5e-07 Smith-Waterman score: 228; 28.481 identity in 158 aa overlap ORF ftt0292; hypothetical protein 306198 3191297 FTT_0292 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169342.1 305722 D 177416 CDS YP_169343.1 56707447 3191295 306177..307196 1 NC_006570.2 Similar to Q88LA6 Von Willebrand factor type A domain protein from Pseuodmonas putida (358 aa). FASTA: opt: 905 Z-score: 1015.4 E(): 1.1e-48 Smith-Waterman score: 905; 45.122 identity in 328 aa overlap ORF ftt0293; hypothetical protein 307196 3191295 FTT_0293 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169343.1 306177 D 177416 CDS YP_008492911.1 537470113 16744727 307198..308196 1 NC_006570.2 hypothetical protein 308196 16744727 FTT_0293a Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_008492911.1 307198 D 177416 CDS YP_169344.1 56707448 3191293 308992..310617 1 NC_006570.2 Similar to Q8ECP0 Conserved hypothetical protein from Shewanella oneidensis (555 aa). FASTA: opt: 529 Z-score: 628.4 E(): 4.1e-27 Smith-Waterman score: 529; 24.371 identity in 517 aa overlap ORF ftt0295; hypothetical protein 310617 3191293 FTT_0295 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169344.1 308992 D 177416 CDS YP_169345.1 56707449 3191452 310618..311295 1 NC_006570.2 Similar to PCP_CLOPE (Q8XKH1) Pyrrolidone-carboxylate peptidase from Clostridium perfringens (215 aa). FASTA: opt: 710 Z-score: 844.3 E(): 3.9e-39 Smith-Waterman score: 710; 52.020identity in 198 aa overlap; pyrrolidone-carboxylate peptidase 311295 pcp 3191452 pcp Francisella tularensis subsp. tularensis SCHU S4 pyrrolidone-carboxylate peptidase YP_169345.1 310618 D 177416 CDS YP_169346.1 56707450 3191292 311303..311785 1 NC_006570.2 ORF ftt0297; cytochrome c-type biogenesis protein 311785 3191292 FTT_0297 Francisella tularensis subsp. tularensis SCHU S4 cytochrome c-type biogenesis protein YP_169346.1 311303 D 177416 CDS YP_169347.1 56707451 3192526 311816..312256 1 NC_006570.2 Similar to Q8XWQ9 Probable DNA polymerase III (CHI subunit) protein from Ralstonia solanacearum (142 aa). FASTA: opt: 142 Z-score: 187.9 E(): 0.013 Smith-Waterman score: 142; 30.000identity in 120 aa overlap; DNA polymerase III subunit chi 312256 holC 3192526 holC Francisella tularensis subsp. tularensis SCHU S4 DNA polymerase III subunit chi YP_169347.1 311816 D 177416 CDS YP_169348.1 56707452 3191933 312388..315147 1 NC_006570.2 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 315147 valS 3191933 valS Francisella tularensis subsp. tularensis SCHU S4 valyl-tRNA synthetase YP_169348.1 312388 D 177416 CDS YP_169349.1 56707453 3191289 315176..316030 1 NC_006570.2 ORF ftt0300; hypothetical protein 316030 3191289 FTT_0300 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169349.1 315176 D 177416 CDS YP_169350.1 56707454 3191288 316103..316972 1 NC_006570.2 ORF ftt0301; hypothetical protein 316972 3191288 FTT_0301 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169350.1 316103 D 177416 CDS YP_169351.1 56707455 3191287 317156..317491 1 NC_006570.2 ORF ftt0302; hypothetical protein 317491 3191287 FTT_0302 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169351.1 317156 D 177416 CDS YP_169352.1 56707456 3191464 complement(317488..318645) 1 NC_006570.2 Similar to Q9JTX1 L-lactate dehydrogenase from Neisseria meningitidis (390 aa). FASTA: opt: 1591 Z-score: 1977.5 E(): 3e-102 Smith-Waterman score: 1591; 60.789 identity in 380 aa overlap; L-lactate dehydrogenase 318645 lldD1 3191464 lldD1 Francisella tularensis subsp. tularensis SCHU S4 L-lactate dehydrogenase YP_169352.1 317488 R 177416 CDS YP_169353.1 56707457 3191694 complement(318672..319325) 1 NC_006570.2 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 319325 nfnB 3191694 nfnB Francisella tularensis subsp. tularensis SCHU S4 dihydropteridine reductase YP_169353.1 318672 R 177416 CDS YP_169354.1 56707458 3191286 319465..319842 1 NC_006570.2 Similar to Q88NZ1 MutT/nudix family protein from Pseuodomonas putida (137 aa). FASTA: opt: 224 Z-score: 293.2 E(): 1.8e-08 Smith-Waterman score: 224; 34.545 identity in 110 aa overlap ORF ftt0305; MutT/nudix family protein 319842 3191286 FTT_0305 Francisella tularensis subsp. tularensis SCHU S4 MutT/nudix family protein YP_169354.1 319465 D 177416 CDS YP_169355.1 56707459 3191124 320015..321406 1 NC_006570.2 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 321406 fumC 3191124 fumC Francisella tularensis subsp. tularensis SCHU S4 fumarate hydratase YP_169355.1 320015 D 177416 CDS YP_169356.1 56707460 3191767 321536..322942 1 NC_006570.2 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 322942 gltX 3191767 gltX Francisella tularensis subsp. tularensis SCHU S4 glutamyl-tRNA synthetase YP_169356.1 321536 D 177416 CDS YP_169357.1 56707461 3191285 322933..323910 1 NC_006570.2 ORF ftt0308; hypothetical protein 323910 3191285 FTT_0308 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169357.1 322933 D 177416 CDS YP_169358.1 56707462 3190862 complement(323934..324677) 1 NC_006570.2 ISFtu2. Transposase, member of the IS5 family. Identical to Q8GM03 transposase from Francisella tularensis (247 aa).; transposase 324677 isftu2 3190862 isftu2 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169358.1 323934 R 177416 CDS YP_169359.1 56707463 3191283 324973..326427 1 NC_006570.2 Similar to Q8XT33 Probable amino-acid permease transmembrane protein from Ralstonia solanacearum (543 aa). FASTA: opt: 999 Z-score: 1146.0 E(): 5.5e-5 Smith-Waterman score: 999; 34.924 identity in 461 aa overlap ORF ftt0310; amino acid permease 326427 3191283 FTT_0310 Francisella tularensis subsp. tularensis SCHU S4 amino acid permease YP_169359.1 324973 D 177416 CDS YP_169360.1 56707464 3191081 complement(326759..327682) 1 NC_006570.2 Similar to Q9KKV6 Hypothetical protein VCA0994 from Vibrio cholerae (326 aa). FASTA: opt: 558 Z-score: 686.8 E(): 2.3e-30 Smith-Waterman score: 558; 31.949 identity in 313 aa overlap ORF ftt0311c; hypothetical protein 327682 3191081 FTT_0311c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169360.1 326759 R 177416 CDS YP_169361.1 56707465 3191943 complement(327764..328264) 1 NC_006570.2 Similar to Q9K7B6 Dihydrofolate reductase from Bacillus halodurans (163 aa). FASTA: opt: 465 Z-score: 598.3 E(): 2e-25 Smith-Waterman score: 465; 41.566 identity in 166 aa overlap; dihydrofolate reductase type I 328264 folA 3191943 folA Francisella tularensis subsp. tularensis SCHU S4 dihydrofolate reductase type I YP_169361.1 327764 R 177416 CDS YP_169362.1 56707466 3191975 328496..329215 1 NC_006570.2 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 329215 rpsB 3191975 rpsB Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S2 YP_169362.1 328496 D 177416 CDS YP_169363.1 56707467 3191005 329237..330106 1 NC_006570.2 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 330106 tsf 3191005 tsf Francisella tularensis subsp. tularensis SCHU S4 elongation factor Ts YP_169363.1 329237 D 177416 CDS YP_169364.1 56707468 3191650 330110..330859 1 NC_006570.2 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 330859 pyrH 3191650 pyrH Francisella tularensis subsp. tularensis SCHU S4 uridylate kinase YP_169364.1 330110 D 177416 CDS YP_169365.1 56707469 3191428 330888..331445 1 NC_006570.2 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 331445 frr 3191428 frr Francisella tularensis subsp. tularensis SCHU S4 ribosome recycling factor YP_169365.1 330888 D 177416 CDS YP_169366.1 56707470 3191904 331478..332251 1 NC_006570.2 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 332251 uppS 3191904 uppS Francisella tularensis subsp. tularensis SCHU S4 undecaprenyl pyrophosphate synthase YP_169366.1 331478 D 177416 CDS YP_169367.1 56707471 3190936 332265..333059 1 NC_006570.2 Similar to Q88MH5 Phosphatidate cytidylyltransferase from Pseudomonas putida (271 aa). FASTA: 398 opt: 534 Z-score: 626.6 E(): 5.2e-27 Smith-Waterman score: 536; 35.926 identity in 270 aa overlap; phosphatidate cytidylyltransferase 333059 cdsA 3190936 cdsA Francisella tularensis subsp. tularensis SCHU S4 phosphatidate cytidylyltransferase YP_169367.1 332265 D 177416 CDS YP_169368.1 56707472 3191551 333069..333515 1 NC_006570.2 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 333515 dut 3191551 dut Francisella tularensis subsp. tularensis SCHU S4 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_169368.1 333069 D 177416 CDS YP_169369.1 56707473 3191364 333519..334115 1 NC_006570.2 Similar to Q8XFD0 Phosphotidylglycerophosphate synthetase from Salmonella typhi (182 aa). FASTA: opt: 575 Z-score: 728.4 E(): 1.1e-32 Smith-Waterman score: 618; 50.000identity in 188 aa overlap; phosphatidylglycerophosphate synthetase 334115 pgsA 3191364 pgsA Francisella tularensis subsp. tularensis SCHU S4 phosphatidylglycerophosphate synthetase YP_169369.1 333519 D 177416 CDS YP_169370.1 56707474 3191538 334250..334624 1 NC_006570.2 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 334624 rpsL 3191538 rpsL Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S12 YP_169370.1 334250 D 177416 CDS YP_169371.1 56707475 3191970 334663..335136 1 NC_006570.2 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 335136 rpsG 3191970 rpsG Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S7 YP_169371.1 334663 D 177416 CDS YP_169372.1 56707476 3191127 335151..337265 1 NC_006570.2 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 337265 fusA 3191127 fusA Francisella tularensis subsp. tularensis SCHU S4 elongation factor G YP_169372.1 335151 D 177416 CDS YP_169373.1 56707477 3191189 337286..337603 1 NC_006570.2 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 337603 rpsJ 3191189 rpsJ Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S10 YP_169373.1 337286 D 177416 CDS YP_169374.1 56707478 3192021 337707..338342 1 NC_006570.2 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 338342 rplC 3192021 rplC Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L3 YP_169374.1 337707 D 177416 CDS YP_169375.1 56707479 3192020 338372..338995 1 NC_006570.2 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 338995 rplD 3192020 rplD Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L4 YP_169375.1 338372 D 177416 CDS YP_169376.1 56707480 3191999 338992..339291 1 NC_006570.2 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 339291 rplW 3191999 rplW Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L23 YP_169376.1 338992 D 177416 CDS YP_169377.1 56707481 3192022 339313..340137 1 NC_006570.2 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 340137 rplB 3192022 rplB Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L2 YP_169377.1 339313 D 177416 CDS YP_169378.1 56707482 3192508 340152..340430 1 NC_006570.2 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 340430 rpsS 3192508 rpsS Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S19 YP_169378.1 340152 D 177416 CDS YP_169379.1 56707483 3192000 340446..340781 1 NC_006570.2 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 340781 rplV 3192000 rplV Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L22 YP_169379.1 340446 D 177416 CDS YP_169380.3 537470114 3191974 340796..341464 1 NC_006570.2 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 341464 rpsC 3191974 rpsC Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S3 YP_169380.3 340796 D 177416 CDS YP_169381.1 56707485 3192008 341468..341881 1 NC_006570.2 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 341881 rplP 3192008 rplP Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L16 YP_169381.1 341468 D 177416 CDS YP_169382.1 56707486 3191993 341881..342081 1 NC_006570.2 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 342081 rpmC 3191993 rpmC Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L29 YP_169382.1 341881 D 177416 CDS YP_169383.1 56707487 3191023 342094..342345 1 NC_006570.2 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 342345 rpsQ 3191023 rpsQ Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S17 YP_169383.1 342094 D 177416 CDS YP_169384.1 56707488 3192011 342437..342805 1 NC_006570.2 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 342805 rplN 3192011 rplN Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L14 YP_169384.1 342437 D 177416 CDS YP_169385.1 56707489 3191998 342827..343144 1 NC_006570.2 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 343144 rplX 3191998 rplX Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L24 YP_169385.1 342827 D 177416 CDS YP_169386.1 56707490 3192018 343156..343695 1 NC_006570.2 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 343695 rplE 3192018 rplE Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L5 YP_169386.1 343156 D 177416 CDS YP_169387.1 56707491 3192379 343714..344019 1 NC_006570.2 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 344019 rpsN 3192379 rpsN Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S14 YP_169387.1 343714 D 177416 CDS YP_169388.1 56707492 3190958 344036..344434 1 NC_006570.2 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 344434 rpsH 3190958 rpsH Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S8 YP_169388.1 344036 D 177416 CDS YP_169389.1 56707493 3192017 344453..344989 1 NC_006570.2 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 344989 rplF 3192017 rplF Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L6 YP_169389.1 344453 D 177416 CDS YP_169390.1 56707494 3192006 345012..345365 1 NC_006570.2 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 345365 rplR 3192006 rplR Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L18 YP_169390.1 345012 D 177416 CDS YP_169391.1 56707495 3191972 345393..345893 1 NC_006570.2 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 345893 rpsE 3191972 rpsE Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S5 YP_169391.1 345393 D 177416 CDS YP_169392.1 56707496 3191991 345900..346085 1 NC_006570.2 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 346085 rpmD 3191991 rpmD Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L30 YP_169392.1 345900 D 177416 CDS YP_169393.1 56707497 3192010 346092..346523 1 NC_006570.2 late assembly protein; 50S ribosomal protein L15 346523 rplO 3192010 rplO Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L15 YP_169393.1 346092 D 177416 CDS YP_169394.1 56707498 3190709 346534..347859 1 NC_006570.2 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 347859 secY 3190709 secY Francisella tularensis subsp. tularensis SCHU S4 preprotein translocase subunit SecY YP_169394.1 346534 D 177416 CDS YP_169395.1 56707499 3191985 347883..347996 1 NC_006570.2 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 347996 rpmJ 3191985 rpmJ Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L36 YP_169395.1 347883 D 177416 CDS YP_169396.1 56707500 3191860 348113..348469 1 NC_006570.2 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 348469 rpsM 3191860 rpsM Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S13 YP_169396.1 348113 D 177416 CDS YP_169397.1 56707501 3190768 348509..348898 1 NC_006570.2 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 348898 rpsK 3190768 rpsK Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S11 YP_169397.1 348509 D 177416 CDS YP_169398.1 56707502 3191973 348920..349540 1 NC_006570.2 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 349540 rpsD 3191973 rpsD Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S4 YP_169398.1 348920 D 177416 CDS YP_169399.1 56707503 3191984 349598..350569 1 NC_006570.2 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 350569 rpoA1 3191984 rpoA1 Francisella tularensis subsp. tularensis SCHU S4 DNA-directed RNA polymerase subunit alpha YP_169399.1 349598 D 177416 CDS YP_169400.1 56707504 3192007 350614..351051 1 NC_006570.2 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 351051 rplQ 3192007 rplQ Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L17 YP_169400.1 350614 D 177416 CDS YP_169401.1 56707505 3192216 join(351205..351531,351531..351989) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 351989 isftu1 3192216 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169401.1 351205 D 177416 CDS YP_169402.1 56707506 3191453 352918..353913 1 NC_006570.2 Duplicate of FTT0378 and FTT1263 ORF ftt0354; hypothetical protein 353913 3191453 FTT_0354 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169402.1 352918 D 177416 CDS YP_169403.1 56707507 3191882 complement(join(354205..354663,354663..354989)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 354989 isftu1 3191882 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169403.1 354205 R 177416 CDS YP_169404.1 56707508 3191490 355151..357037 1 NC_006570.2 molecular chaperone; heat shock protein 90 357037 htpG 3191490 htpG Francisella tularensis subsp. tularensis SCHU S4 heat shock protein 90 YP_169404.1 355151 D 177416 CDS YP_169405.1 56707509 3192206 complement(join(357361..357819,357819..358145)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 358145 isftu1 3192206 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169405.1 357361 R 177416 CDS YP_169406.1 56707510 3191450 359413..359883 1 NC_006570.2 ORF ftt0359; hypothetical protein 359883 3191450 FTT_0359 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169406.1 359413 D 177416 CDS YP_169407.1 56707511 3191448 360020..360844 1 NC_006570.2 Similar to Q82V84 Short-chain dehydrogenase/reductase (SDR) superfamily from Nitrosomonas europaea (279 aa). FASTA: opt: 829 Z-score: 982.8 E(): 7.5e-47 Smith-Waterman score: 829; 49.632 identity in 272 aa overlap ORF ftt0360; short-chain dehydrogenase 360844 3191448 FTT_0360 Francisella tularensis subsp. tularensis SCHU S4 short-chain dehydrogenase YP_169407.1 360020 D 177416 CDS YP_169408.1 56707512 3191447 complement(360866..362215) 1 NC_006570.2 Similar to Q8Z506 amino acid transporter from Salmonella typhi (473 aa). FASTA: opt: 717 Z-score: 754.8 E(): 3.8e-34 Smith-Waterman score: 755; 29.783 identity in 460 aa overlap ORF ftt0361c; amino acid transporter 362215 3191447 FTT_0361c Francisella tularensis subsp. tularensis SCHU S4 amino acid transporter YP_169408.1 360866 R 177416 CDS YP_169409.1 56707513 3191445 complement(362474..363346) 1 NC_006570.2 ORF ftt0362c; hypothetical protein 363346 3191445 FTT_0362c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169409.1 362474 R 177416 CDS YP_169410.1 56707514 3192291 join(363514..363840,363840..364298) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 364298 isftu1 3192291 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169410.1 363514 D 177416 CDS YP_169411.1 56707515 3191446 complement(364422..364871) 1 NC_006570.2 ORF ftt0364c; hypothetical protein 364871 3191446 FTT_0364c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169411.1 364422 R 177416 CDS YP_169412.1 56707516 3191544 365352..366083 1 NC_006570.2 Similar to Q8PFB8 Phenol hydroxylase from Xanthomonas axonopodis (365 aa). FASTA: opt: 567 Z-score: 717.5 E(): 4.5e-32 Smith-Waterman score: 567; 38.211 identity in 246 aa overlap The protein seems to be shorter (<115 aa) than the matching proteins.; phenol hydroxylase 366083 poxF 3191544 poxF Francisella tularensis subsp. tularensis SCHU S4 phenol hydroxylase YP_169412.1 365352 D 177416 CDS YP_169413.1 56707517 3191990 366205..366420 1 NC_006570.2 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 366420 rpmE 3191990 rpmE Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L31 YP_169413.1 366205 D 177416 CDS YP_169414.1 56707518 3192547 complement(366631..368136) 1 NC_006570.2 Similar to Q88AR1 Glutamate--cysteine ligase from Pseudomonas syringae (529 aa). FASTA: opt: 1113 Z-score: 1281.1 E(): 1.8e-63 Smith-Waterman score: 1113; 39.250 identity in 507 aa overlap; glutamate--cysteine ligase 368136 gshA 3192547 gshA Francisella tularensis subsp. tularensis SCHU S4 glutamate--cysteine ligase YP_169414.1 366631 R 177416 CDS YP_169415.1 56707519 3192066 complement(368189..369733) 1 NC_006570.2 Similar to AAO89943 (Q83ED5) Integral membrane protein MviN from Coxiella burnetii (515 aa). FASTA: opt: 836 Z-score: 887.1 E(): 1.6e-41 Smith-Waterman score: 836; 30.452 identity in 509 aa overlap; virulence factor MviN 369733 mviN 3192066 mviN Francisella tularensis subsp. tularensis SCHU S4 virulence factor MviN YP_169415.1 368189 R 177416 CDS YP_169416.1 56707520 3191442 complement(369756..370817) 1 NC_006570.2 ORF ftt0369c; hypothetical protein 370817 3191442 FTT_0369c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169416.1 369756 R 177416 CDS YP_169417.1 56707521 3192380 complement(370900..371310) 1 NC_006570.2 Similar to Q8Z189 Hypothetical protein yjeE from Salmonella typhi (153 aa). FASTA: opt: 517 Z-score: 623.3 E(): 7.9e-27 Smith-Waterman score: 517; 56.489 identity in 131 aa overlap; nucleotide-binding protein 371310 yjeE 3192380 yjeE Francisella tularensis subsp. tularensis SCHU S4 nucleotide-binding protein YP_169417.1 370900 R 177416 CDS YP_169418.1 56707522 3191937 complement(371288..372469) 1 NC_006570.2 Similar to Q8ECR5 FolC bifunctional protein from Shewanella oneidensis (431 aa). FASTA: opt: 507 Z-score: 630.2 E(): 3.3e-27 Smith-Waterman score: 627; 32.274 identity in 409 aa overlap; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase 372469 folC 3191937 folC Francisella tularensis subsp. tularensis SCHU S4 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase YP_169418.1 371288 R 177416 CDS YP_169419.1 56707523 3191466 complement(372484..373392) 1 NC_006570.2 Similar to Q8XFJ5 Acetyl-CoA carboxylase beta subunit from Salmonella typhi (304 aa). FASTA: opt: 1197 Z-score: 1430.2 E(): 9.1e-72 Smith-Waterman score: 1197; 62.116 identity in 293 aa overlap; acetyl-Coa carboxylase beta subunit 373392 accD 3191466 accD Francisella tularensis subsp. tularensis SCHU S4 acetyl-Coa carboxylase beta subunit YP_169419.1 372484 R 177416 CDS YP_169420.1 56707524 3191686 complement(373428..373850) 1 NC_006570.2 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 373850 ndk 3191686 ndk Francisella tularensis subsp. tularensis SCHU S4 nucleoside diphosphate kinase YP_169420.1 373428 R 177416 CDS YP_169421.1 56707525 3191651 complement(373923..375563) 1 NC_006570.2 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 375563 pyrG 3191651 pyrG Francisella tularensis subsp. tularensis SCHU S4 CTP synthetase YP_169421.1 373923 R 177416 CDS YP_169422.1 56707526 3191440 complement(377481..378539) 1 NC_006570.2 Weak hits at position aa 250-350 to many cytochrome oxidase subunit I eg:(Q85L50). ORF ftt0376c; hypothetical protein 378539 3191440 FTT_0376c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169422.1 377481 R 177416 CDS YP_169423.1 56707527 3192115 join(378906..379235,379235..379690) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 379690 isftu1 3192115 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169423.1 378906 D 177416 CDS YP_169424.1 56707528 3191439 complement(379982..380977) 1 NC_006570.2 Duplicate of FTT0354 and FTT1263 ORF ftt0378c; hypothetical protein 380977 3191439 FTT_0378c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169424.1 379982 R 177416 CDS YP_169425.1 56707529 3191583 complement(382014..383363) 1 NC_006570.2 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 383363 gdh 3191583 gdh Francisella tularensis subsp. tularensis SCHU S4 glutamate dehydrogenase YP_169425.1 382014 R 177416 CDS YP_169426.1 56707530 3192483 383702..384445 1 NC_006570.2 ISFtu2. Transposase, member of the IS5 family. Identical to Q8GM03 transposase from Francisella tularensis (247 aa).; transposase 384445 isftu2 3192483 isftu2 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169426.1 383702 D 177416 CDS YP_169427.1 56707531 3191437 384570..384674 1 NC_006570.2 ORF ftt0382; hypothetical protein 384674 3191437 FTT_0382 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169427.1 384570 D 177416 CDS YP_169428.1 56707532 3191438 385685..386020 1 NC_006570.2 ORF ftt0383; hypothetical protein 386020 3191438 FTT_0383 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169428.1 385685 D 177416 CDS YP_169429.2 255961455 3191677 complement(385993..386844) 1 NC_006570.2 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 386844 psd 3191677 psd Francisella tularensis subsp. tularensis SCHU S4 phosphatidylserine decarboxylase YP_169429.2 385993 R 177416 CDS YP_169430.1 56707534 3191436 386944..387924 1 NC_006570.2 ORF ftt0385; hypothetical protein 387924 3191436 FTT_0385 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169430.1 386944 D 177416 CDS YP_169431.1 56707535 3192435 387933..388976 1 NC_006570.2 NadM-Nudix subfamily; involved in creation of nicotanimide adenine dinucleotide NAD from either biosynthetic or salvage pathways; bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase 388976 nadM 3192435 nadM Francisella tularensis subsp. tularensis SCHU S4 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase YP_169431.1 387933 D 177416 CDS YP_169432.1 56707536 3191075 388990..390357 1 NC_006570.2 Similar to Q9KNH7 UDP-N-acetylglucosamine pyrophosphorylase from Vibrio cholerae (453 aa). FASTA: opt: 1597 Z-score: 1863.6 E(): 6.5e-96 Smith-Waterman score: 1597; 53.201 identity in 453 aa overlap; UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase 390357 glmU 3191075 glmU Francisella tularensis subsp. tularensis SCHU S4 UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase YP_169432.1 388990 D 177416 CDS YP_169433.1 56707537 3192352 390378..392216 1 NC_006570.2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 392216 glmS 3192352 glmS Francisella tularensis subsp. tularensis SCHU S4 glucosamine--fructose-6-phosphate aminotransferase YP_169433.1 390378 D 177416 CDS YP_169434.1 56707538 3191435 392300..392824 1 NC_006570.2 Similar to Q9RWR2 Acetyltransferase, , from Deinococcus radiodurans (188 aa). FASTA: opt: 188 Z-score: 245.7 E(): 8.5e-06 Smith-Waterman score: 188; 28.105 identity in 153 aa overlap ORF ftt0389; acetyltransferase 392824 3191435 FTT_0389 Francisella tularensis subsp. tularensis SCHU S4 acetyltransferase YP_169434.1 392300 D 177416 CDS YP_169435.1 56707539 3191264 complement(392817..393014) 1 NC_006570.2 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 393014 rpsU 3191264 rpsU Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S21 YP_169435.1 392817 R 177416 CDS YP_169436.1 56707540 3191899 complement(393014..393217) 1 NC_006570.2 Similar to Q8D6M5 Cold shock protein from Vibrio vulnificus (70 aa). FASTA: opt: 272 Z-score: 403.6 E(): 1.4e-14 Smith-Waterman score: 272; 58.571 identity in 70 aa overlap; cold shock protein 393217 cspC 3191899 cspC Francisella tularensis subsp. tularensis SCHU S4 cold shock protein YP_169436.1 393014 R 177416 CDS YP_169437.1 56707541 3191434 complement(393465..393794) 1 NC_006570.2 Similar to Q8TT97 Hypothetical protein MA0540 from Methanosarcina mazei (95 aa). FASTA: opt: 151 Z-score: 197.5 E(): 0.0038 Smith-Waterman score: 151; 35.789 identity in 95 aa overlap ORF ftt0392c; hypothetical protein 393794 3191434 FTT_0392c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169437.1 393465 R 177416 CDS YP_169438.1 56707542 3191507 393921..394691 1 NC_006570.2 Similar to Q886P4 Methionine aminopeptidase,type I from Pseudomonas syringae (260 aa). FASTA: opt: 1243 Z-score: 1568.2 E(): 1.9e-79 Smith-Waterman score: 1243; 70.120 identity in 251 aa overlap; methionine aminopeptidase 394691 map 3191507 map Francisella tularensis subsp. tularensis SCHU S4 methionine aminopeptidase YP_169438.1 393921 D 177416 CDS YP_169439.1 56707543 3191432 394693..395541 1 NC_006570.2 ORF ftt0394; hypothetical protein 395541 3191432 FTT_0394 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169439.1 394693 D 177416 CDS YP_169440.1 56707544 3191429 395587..396300 1 NC_006570.2 Similar to Q9L5J1 hypothetical protein from Salmonella typhi (259 aa). FASTA: opt: 585 Z-score: 707.5 E(): 1.6e-31 Smith-Waterman score: 680; 46.743 identity in 261 aa overlap ORF ftt0395; hypothetical protein 396300 3191429 FTT_0395 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169440.1 395587 D 177416 CDS YP_169441.1 56707545 3191415 396433..398658 1 NC_006570.2 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 398658 parC 3191415 parC Francisella tularensis subsp. tularensis SCHU S4 DNA topoisomerase IV subunit A YP_169441.1 396433 D 177416 CDS YP_169442.1 56707546 3191248 398658..399344 1 NC_006570.2 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 399344 mtn 3191248 mtn Francisella tularensis subsp. tularensis SCHU S4 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_169442.1 398658 D 177416 CDS YP_169443.1 56707547 3191430 complement(399331..399930) 1 NC_006570.2 ORF ftt0398c; hypothetical protein 399930 3191430 FTT_0398c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169443.1 399331 R 177416 CDS YP_169444.1 56707548 3191433 complement(399923..401041) 1 NC_006570.2 Similar to Q885D8 BNR/Asp-box repeat protein from Pseudomonas syringae (432 aa). FASTA: opt: 536 Z-score: 654.4 E(): 1.5e-28 Smith-Waterman score: 536; 31.922 identity in 307 aa overlap ORF ftt0399c; BNR/Asp-box repeat-containing protein 401041 3191433 FTT_0399c Francisella tularensis subsp. tularensis SCHU S4 BNR/Asp-box repeat-containing protein YP_169444.1 399923 R 177416 CDS YP_169445.1 56707549 3190706 401240..403216 1 NC_006570.2 Similar to Q88L07 Soluble lytic transglycosylase, from Pseudomonas putida (657 aa). FASTA: opt: 596 Z-score: 646.0 E(): 3.9e-28 Smith-Waterman score: 819; 27.822 identity in 629 aa overlap.; soluble lytic murein transglycosylase 403216 slt 3190706 slt Francisella tularensis subsp. tularensis SCHU S4 soluble lytic murein transglycosylase YP_169445.1 401240 D 177416 CDS YP_169446.1 56707550 3191427 403506..404228 1 NC_006570.2 Partial homology to carboxy terminus of Q9CLV4a Hypothetical protein PM1097 from Pasteurella multocida (417 aa). FASTA: opt: 269 Z-score: 330.3 E(): 1.7e-10 Smith-Waterman score: 269; 26.050identity in 238 aa overlap ORF ftt0401; hypothetical protein 404228 3191427 FTT_0401 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169446.1 403506 D 177416 CDS YP_169447.1 56707551 3191527 404585..408064 1 NC_006570.2 Similar to DP3A_SALTY (P14567) DNA polymerase III alpha subunit from Salmonella typhimurium (1160 aa). FASTA: opt: 3099 Z-score: 3288.3 E(): 2.6e-175 Smith-Waterman score: 3099; 44.781identity in 1121 aa overlap.; DNA polymerase III subunit alpha 408064 dnaE 3191527 dnaE Francisella tularensis subsp. tularensis SCHU S4 DNA polymerase III subunit alpha YP_169447.1 404585 D 177416 CDS YP_169448.1 56707552 3191512 408140..408775 1 NC_006570.2 Similar to DEF_LEPIN (Q93LE9) Peptide deformylase from Leptospira interrogans (178 aa). FASTA: opt: 312 Z-score: 399.2 E(): 2.4e-14 Smith-Waterman score: 312; 35.758 identity in 165 aa overlap; peptide deformylase 408775 def1 3191512 def1 Francisella tularensis subsp. tularensis SCHU S4 peptide deformylase YP_169448.1 408140 D 177416 CDS YP_169449.1 56707553 3192203 409479..410741 1 NC_006570.2 Similar to Q83CV1 lipoprotein ABC transporter,permease protein from Coxiella burnetii (414 aa). FASTA: opt: 1273 Z-score: 1436.4 E(): 4.1e-72 Smith-Waterman score: 1273; 48.104 identity in 422 aa overlap; lipoprotein releasing system membrane protein 410741 lolC 3192203 lolC Francisella tularensis subsp. tularensis SCHU S4 lipoprotein releasing system membrane protein YP_169449.1 409479 D 177416 CDS YP_169450.1 56707554 3192199 410734..411429 1 NC_006570.2 Similar to LOLD_NEIMA (P57030) Lipoprotein releasing system ATP-binding transport protein from Neisseria meningitidis (231 aa). FASTA: opt: 791 Z-score: 892.8 E(): 7e-42 Smith-Waterman score: 791; 51.770 identity in 226 aa overlap; lipoprotein releasing system ABC transporter ATP-binding protein 411429 lolD 3192199 lolD Francisella tularensis subsp. tularensis SCHU S4 lipoprotein releasing system ABC transporter ATP-binding protein YP_169450.1 410734 D 177416 CDS YP_169451.1 56707555 3191271 411546..413687 1 NC_006570.2 Similar to DCLY_ECOLI (P23892) Lysine decarboxylase, inducible from E. coli (715 aa) FASTA: opt: 2608 Z-score: 3095.0 E(): 1.7e-164 Smith-Waterman score: 2608; 53.912 identity in 703 aa overlap; lysine decarboxylase, inducable 413687 cadA 3191271 cadA Francisella tularensis subsp. tularensis SCHU S4 lysine decarboxylase, inducable YP_169451.1 411546 D 177416 CDS YP_169452.1 56707556 3192518 413779..414855 1 NC_006570.2 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 414855 gcvT 3192518 gcvT Francisella tularensis subsp. tularensis SCHU S4 glycine cleavage system aminomethyltransferase T YP_169452.1 413779 D 177416 CDS YP_169453.1 56707557 3191553 414911..415294 1 NC_006570.2 Similar to Q8FE66 Glycine cleavage system H protein from E coli (130 aa). FASTA: opt: 526 Z-score: 699.9 E(): 4.3e-31 Smith-Waterman score: 526; 60.938 identity in 128 aa overlap; glycine cleavage system H protein 415294 gcvH1 3191553 gcvH1 Francisella tularensis subsp. tularensis SCHU S4 glycine cleavage system H protein YP_169453.1 414911 D 177416 CDS YP_169454.1 56707558 3192502 415358..416725 1 NC_006570.2 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein; glycine dehydrogenase subunit 1 416725 gcvP1 3192502 gcvP1 Francisella tularensis subsp. tularensis SCHU S4 glycine dehydrogenase subunit 1 YP_169454.1 415358 D 177416 CDS YP_169455.1 56707559 3192315 416731..418176 1 NC_006570.2 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; glycine dehydrogenase subunit 2 418176 gcvP2 3192315 gcvP2 Francisella tularensis subsp. tularensis SCHU S4 glycine dehydrogenase subunit 2 YP_169455.1 416731 D 177416 CDS YP_169456.1 56707560 3190949 complement(418296..419141) 1 NC_006570.2 Similar to Q8FQC7 shikimate 5-dehydrogenase from Corynebacterium efficiens(269 aa). FASTA: opt: 283 Z-score: 321.7 E(): 4.6e-10 Smith-Waterman score: 287; 28.077 identity in 260 aa overlap.; shikimate 5-dehydrogenase 419141 aroE2 3190949 aroE2 Francisella tularensis subsp. tularensis SCHU S4 shikimate 5-dehydrogenase YP_169456.1 418296 R 177416 CDS YP_169457.1 56707561 3191967 complement(419167..422379) 1 NC_006570.2 Similar to Q8XK16 Pullulanase from Clostridium perfringens (1064 aa). FASTA: opt: 3419 Z-score: 3958.4 E(): 1.4e-212 Smith-Waterman score: 3419; 48.369identity in 1042 aa overlap Other FASTA hits have lower scores due to generally being smaller in size. Q8XK16 is an electronic annotation; pullulonase 422379 pulB 3191967 pulB Francisella tularensis subsp. tularensis SCHU S4 pullulonase YP_169457.1 419167 R 177416 CDS YP_169458.1 56707562 3190770 complement(422413..424335) 1 NC_006570.2 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 424335 glgB 3190770 glgB Francisella tularensis subsp. tularensis SCHU S4 glycogen branching protein YP_169458.1 422413 R 177416 CDS YP_169459.1 56707563 3191363 424637..426271 1 NC_006570.2 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 426271 pgm 3191363 pgm Francisella tularensis subsp. tularensis SCHU S4 phosphoglucomutase YP_169459.1 424637 D 177416 CDS YP_169460.1 56707564 3192504 427587..429056 1 NC_006570.2 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 429056 glgA 3192504 glgA Francisella tularensis subsp. tularensis SCHU S4 glycogen synthase YP_169460.1 427587 D 177416 CDS YP_169461.1 56707565 3191867 429161..431434 1 NC_006570.2 Similar to Q8DN49 Maltodextrin phosphorylase from Streptococcus pneumoniae (752 aa). FASTA: opt: 2938 Z-score: 3443.0 E(): 6.9e-184 Smith-Waterman score: 2938; 59.569 identity in 742 aa overlap; maltodextrin phosphorylase 431434 malP 3191867 malP Francisella tularensis subsp. tularensis SCHU S4 maltodextrin phosphorylase YP_169461.1 429161 D 177416 CDS YP_169462.1 56707566 3192205 431478..432941 1 NC_006570.2 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 432941 malA 3192205 malA Francisella tularensis subsp. tularensis SCHU S4 4-alpha-glucanotransferase YP_169462.1 431478 D 177416 CDS YP_169463.1 56707567 3191773 433015..433923 1 NC_006570.2 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 433923 glyQ 3191773 glyQ Francisella tularensis subsp. tularensis SCHU S4 glycyl-tRNA synthetase subunit alpha YP_169463.1 433015 D 177416 CDS YP_169464.1 56707568 3191957 434134..435573 1 NC_006570.2 Similar to MURE_NEIMB (Q9K0Y9) UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase from Neisseria meningitidis (492 aa). FASTA: opt: 1037 Z-score: 1223.7, E(): 2.9e-60 Smith-Waterman score: 1037; 40.795 identity in 478 aa overlap; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 435573 murE 3191957 murE Francisella tularensis subsp. tularensis SCHU S4 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_169464.1 434134 D 177416 CDS YP_169465.1 56707569 3191072 436365..437723 1 NC_006570.2 Similar to Q87SG8 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate -D-alanyl-D-alanyl ligase from Vibrio parahaemolyticus (454 aa). FASTA: opt: 870 Z-score: 1005.8 E(): 3.9e-48 Smith-Waterman score: 870; 35.011 identity in 457 aa overlap; UDP-N--acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase 437723 murF 3191072 murF Francisella tularensis subsp. tularensis SCHU S4 UDP-N--acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase YP_169465.1 436365 D 177416 CDS YP_169466.1 56707570 3191424 437732..437911 1 NC_006570.2 ORF ftt0423; hypothetical protein 437911 3191424 FTT_0423 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169466.1 437732 D 177416 CDS YP_169468.1 56707572 3190952 complement(438607..439701) 1 NC_006570.2 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 439701 asd 3190952 asd Francisella tularensis subsp. tularensis SCHU S4 aspartate-semialdehyde dehydrogenase YP_169468.1 438607 R 177416 CDS YP_169469.1 56707573 3190776 443011..444297 1 NC_006570.2 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 444297 thrC1 3190776 thrC1 Francisella tularensis subsp. tularensis SCHU S4 threonine synthase YP_169469.1 443011 D 177416 CDS YP_169470.1 56707574 3190726 444938..445372 1 NC_006570.2 Similar to SPEH_METJA (Q57763) S-adenosylmethionine decarboxylase proenzyme from Methanococcus jannaschii (124 aa). FASTA: opt: 355 Z-score: 487.2, E(): 3e-19 Smith-Waterman score: 355; 44.737 identity in 114 aa overlap; S-adenosylmethionine decarboxylase 445372 speH 3190726 speH Francisella tularensis subsp. tularensis SCHU S4 S-adenosylmethionine decarboxylase YP_169470.1 444938 D 177416 CDS YP_169471.1 56707575 3190722 445372..446241 1 NC_006570.2 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 446241 speE 3190722 speE Francisella tularensis subsp. tularensis SCHU S4 spermidine synthase YP_169471.1 445372 D 177416 CDS YP_169472.1 56707576 3190717 446267..447676 1 NC_006570.2 Similar to Q8A2B1 arginine decarboxylase from Bacteroides thetaiotamicron (630 aa). FASTA: opt: 571 Z-score: 678.2 E(): 6.9e-30 Smith-Waterman score: 689; 28.755 identity in 546 aa overlap; arginine decarboxylase 447676 speA 3190717 speA Francisella tularensis subsp. tularensis SCHU S4 arginine decarboxylase YP_169472.1 446267 D 177416 CDS YP_169473.1 56707577 3191423 447726..447914 1 NC_006570.2 ORF ftt0433; hypothetical protein 447914 3191423 FTT_0433 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169473.1 447726 D 177416 CDS YP_169474.1 56707578 3191422 447895..448881 1 NC_006570.2 Similar to Q8KCB6 Hypothetical protein CT1508 from Chlorobium tepidum (347 aa). FASTA: opt: 742 Z-score: 939.4 E(): 2e-44 Smith-Waterman score: 837; 38.484 identity in 343 aa overlap PAD_porph is a possible virulence factor for P. gingivalis: PMID: 10377098 ORF ftt0434; hypothetical protein 448881 3191422 FTT_0434 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169474.1 447895 D 177416 CDS YP_169475.1 56707579 3191421 448883..449743 1 NC_006570.2 Similar to Q87NU4 carbon-nitrogen hydrolase from Vibrio parahaemolyticus (288 aa). FASTA: opt: 1139 Z-score: 1419.0 E(): 3.8e-71 Smith-Waterman score: 1139; 57.971 identity in 276 aa overlap. Possible candidate for citrulline ureidase ORF ftt0435; carbon-nitrogen hydrolase family protein 449743 3191421 FTT_0435 Francisella tularensis subsp. tularensis SCHU S4 carbon-nitrogen hydrolase family protein YP_169475.1 448883 D 177416 CDS YP_169476.1 56707580 3191794 complement(449760..450476) 1 NC_006570.2 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 450476 lpxH 3191794 lpxH Francisella tularensis subsp. tularensis SCHU S4 UDP-2,3-diacylglucosamine hydrolase YP_169476.1 449760 R 177416 CDS YP_169477.1 56707581 3191653 complement(450466..451092) 1 NC_006570.2 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 451092 pyrE 3191653 pyrE Francisella tularensis subsp. tularensis SCHU S4 orotate phosphoribosyltransferase YP_169477.1 450466 R 177416 CDS YP_169478.1 56707582 3191609 451252..452622 1 NC_006570.2 Similar to MPL_ECOLI (P37773) UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso- diamino pimelate ligase (murein peptide ligase) from E coli (457 aa). FASTA: opt: 1392, Z-score: 1656.5, E(): 2.3e-84,Smith-Waterman score: 1392; 47.912 identity in 455 aa overlap; UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 452622 mpl 3191609 mpl Francisella tularensis subsp. tularensis SCHU S4 UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase YP_169478.1 451252 D 177416 CDS YP_169479.1 56707583 3192391 452619..453275 1 NC_006570.2 Similar to YJFH_ECOLI (P39290) hypothetical tRNA/rRNA methyltransferase yjfH from E. coli (243 aa). FASTA: opt: 556, Z-score: 695.5, E(): 7.5e-31 Smith-Waterman score: 556; 43.128 identity in 211 aa overlap. This CDS is disrupted by the insertion of an ISFtu1 element close to the C-terminal. It is not clear whether this insertion affects the function of the protein; tRNA/rRNA methyltransferase 453275 yjfH 3192391 yjfH Francisella tularensis subsp. tularensis SCHU S4 tRNA/rRNA methyltransferase YP_169479.1 452619 D 177416 CDS YP_169480.1 56707584 3191789 complement(join(453349..453807,453807..454133)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 454133 isftu1 3191789 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169480.1 453349 R 177416 CDS YP_169481.1 56707585 3191419 complement(455004..456197) 1 NC_006570.2 Similar to Q8EU72 Bicyclomycin resistance protein from Oceanobacillus iheyensis (412 aa). FASTA: opt: 614 Z-score: 668.2 E(): 2.5e-29 Smith-Waterman score: 614; 30.179identity in 391 aa overlap ORF ftt0442c; major facilitator transporter 456197 3191419 FTT_0442c Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_169481.1 455004 R 177416 CDS YP_169482.1 56707586 3191417 456469..457512 1 NC_006570.2 Similar to Q83C03 Conserved domain protein from Coxiella burnetii (377 aa). FASTA: opt: 359 Z-score: 409.9 E(): 6.1e-15 Smith-Waterman score: 380; 27.350 identity in 351 aa overlap ORF ftt0443; hypothetical protein 457512 3191417 FTT_0443 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169482.1 456469 D 177416 CDS YP_169483.1 56707587 3190751 457583..458821 1 NC_006570.2 Similar to Q83CB9 Multidrug transporter, from Coxiella burnetii (412 aa). FASTA: opt: 558 Z-score: 638.9 E(): 1.1e-27 Smith-Waterman score: 558; 25.854identity in 410 aa overlap. Similar to tetA and tetC which are situated on a plasmid in E. coli; multidrug transporter 458821 tet 3190751 tet Francisella tularensis subsp. tularensis SCHU S4 multidrug transporter YP_169483.1 457583 D 177416 CDS YP_169484.1 56707588 3191413 460752..462194 1 NC_006570.2 Similar to Q83RB7 transport protein from Shigella flexneri (500 aa). FASTA: opt: 567 Z-score: 573.2 E(): 4.9e-24 Smith-Waterman score: 578; 26.122 identity in 490 aa overlap ORF ftt0446; proton-dependent oligopeptide transport (POT) family protein 462194 3191413 FTT_0446 Francisella tularensis subsp. tularensis SCHU S4 proton-dependent oligopeptide transport (POT) family protein YP_169484.1 460752 D 177416 CDS YP_169485.1 56707589 3191414 complement(462338..463678) 1 NC_006570.2 Similar to Q83DW3 Hypothetical protein from Coxiella burnetii (497 aa). FASTA: opt: 334 Z-score: 356.6 E(): 5.7e-12 Smith-Waterman score: 336; 24.129 identity in 402 aa overlap ORF ftt0447c; hypothetical protein 463678 3191414 FTT_0447c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169485.1 462338 R 177416 CDS YP_169486.1 56707590 3190997 complement(463699..465345) 1 NC_006570.2 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 465345 glnS 3190997 glnS Francisella tularensis subsp. tularensis SCHU S4 glutaminyl-tRNA synthetase YP_169486.1 463699 R 177416 CDS YP_169487.1 56707591 3191431 465490..467082 1 NC_006570.2 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 467082 pckA 3191431 pckA Francisella tularensis subsp. tularensis SCHU S4 phosphoenolpyruvate carboxykinase YP_169487.1 465490 D 177416 CDS YP_169488.1 56707592 3191161 467157..468254 1 NC_006570.2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 468254 mraY 3191161 mraY Francisella tularensis subsp. tularensis SCHU S4 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_169488.1 467157 D 177416 CDS YP_169489.1 56707593 3191954 468254..469504 1 NC_006570.2 Similar to MURD_CHLCV (Q821S1) UDP-N-acetylmuramoylalanine--D-glutamate ligase from Chlamydophila caviae (419 aa) FASTA: opt: 516 Z-score: 615.2 E(): 2.2e-26 Smith-Waterman score: 549; 28.000 identity in 425 aa overlap; UDP-N-acetylmuramoylalanine--D-glutamate ligase 469504 murD 3191954 murD Francisella tularensis subsp. tularensis SCHU S4 UDP-N-acetylmuramoylalanine--D-glutamate ligase YP_169489.1 468254 D 177416 CDS YP_169490.1 56707594 3190868 469514..470719 1 NC_006570.2 Similar to Q9KPG6 Cell division protein FtsW from Vibrio cholerae (398 aa). FASTA: opt: 1114 Z-score: 1237.3 E(): 5e-61 Smith-Waterman score: 1114; 44.892 identity in 372 aa overlap; cell division protein FtsW 470719 ftsW 3190868 ftsW Francisella tularensis subsp. tularensis SCHU S4 cell division protein FtsW YP_169490.1 469514 D 177416 CDS YP_169491.1 56707595 3191411 complement(470727..471533) 1 NC_006570.2 Similar to Q83DW2 Hypothetical protein from Coxiella burnetii (273 aa). FASTA: opt: 554 Z-score: 648.8 E(): 3e-28 Smith-Waterman score: 554; 37.407identity in 270 aa overlap ORF ftt0453c; hypothetical protein 471533 3191411 FTT_0453c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169491.1 470727 R 177416 CDS YP_169492.1 56707596 3192164 471632..472588 1 NC_006570.2 Similar to Q83DW4 Glycosyl transferase, group 2 family protein from Coxiella burnetii (324 aa). FASTA: opt: 896 Z-score: 1055.7 E(): 6.5e-51 Smith-Waterman score: 896; 43.189identity in 301 aa overlap; glycosyl transferase family protein 472588 yfdH 3192164 yfdH Francisella tularensis subsp. tularensis SCHU S4 glycosyl transferase family protein YP_169492.1 471632 D 177416 CDS YP_169493.1 56707597 3191408 complement(472980..474743) 1 NC_006570.2 Similar to Q8XQM9 Probable transmembrane protein from Ralstonia solanacearum (551 aa). FASTA: opt: 683 Z-score: 749.4 E(): 7.6e-34 Smith-Waterman score: 683; 29.174 identity in 545 aa overlap ORF ftt0455c; dolichyl-phosphate-mannose-protein mannosyltransferase family protein 474743 3191408 FTT_0455c Francisella tularensis subsp. tularensis SCHU S4 dolichyl-phosphate-mannose-protein mannosyltransferase family protein YP_169493.1 472980 R 177416 CDS YP_169494.1 56707598 3191407 complement(474835..475128) 1 NC_006570.2 Similar to Y941_COXBU Hypothetical UPF0269 protein CBU0941 from Coxiella burnetii (90 aa). FASTA: opt: 346 Z-score: 470.4 E(): 2.6e-18 Smith-Waterman score: 346; 55.422 identity in 83 aa overlap ORF ftt0456c; hypothetical protein 475128 3191407 FTT_0456c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169494.1 474835 R 177416 CDS YP_169495.1 56707599 3192160 complement(475119..475433) 1 NC_006570.2 Similar to Q9CNM6 Hypothetical protein PM0401 from Pasteurella multocida (109 aa). initn: 382 init1: 382 opt: 382 Z-score: 511.4 bits: 99.7 E(): 1.4e-20 Smith-Waterman score: 382; 58.586identity (58.58639ngapped) in 99 aa overlap; anaerobic sulfite reductase subunit 475433 yccK 3192160 yccK Francisella tularensis subsp. tularensis SCHU S4 anaerobic sulfite reductase subunit YP_169495.1 475119 R 177416 CDS YP_169496.1 56707600 3190731 475519..476151 1 NC_006570.2 Similar to SSPA_HAESO (P31784) Stringent starvation protein A homolog from Haemophilus somnus (212 aa). FASTA: opt: 377 Z-score: 473.8 E(): 1.7e-18 Smith-Waterman score: 377; 35.106 identity in 188 aa overlap; stringent starvation protein A 476151 sspA 3190731 sspA Francisella tularensis subsp. tularensis SCHU S4 stringent starvation protein A YP_169496.1 475519 D 177416 CDS YP_169497.1 56707601 3190718 476163..477182 1 NC_006570.2 SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 477182 sohB 3190718 sohB Francisella tularensis subsp. tularensis SCHU S4 periplasmic protease YP_169497.1 476163 D 177416 CDS YP_169498.1 56707602 3192338 477190..478101 1 NC_006570.2 Similar to Q8D3A6 HolB protein from Wigglesworthia glossinidia brevipalpis (329 aa). FASTA: opt: 315 Z-score: 378.8 E(): 3.3e-13 Smith-Waterman score: 315; 27.304 identity in 293 aa overlap; DNA polymerase III subunit delta' 478101 holB 3192338 holB Francisella tularensis subsp. tularensis SCHU S4 DNA polymerase III subunit delta' YP_169498.1 477190 D 177416 CDS YP_169499.1 56707603 3191267 478112..478390 1 NC_006570.2 Similar to Q87LZ3 RNA-binding protein containing KH domain from Vibrio parahaemolyticus (98 aa). FASTA: opt: 289 Z-score: 405.9 E(): 1e-14 Smith-Waterman score: 289; 52.222 identity in 90 aa overlap; RNA-binding protein 478390 yhbY 3191267 yhbY Francisella tularensis subsp. tularensis SCHU S4 RNA-binding protein YP_169499.1 478112 D 177416 CDS YP_169500.1 56707604 3192415 478398..479372 1 NC_006570.2 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 479372 hemB 3192415 hemB Francisella tularensis subsp. tularensis SCHU S4 delta-aminolevulinic acid dehydratase YP_169500.1 478398 D 177416 CDS YP_169501.1 56707605 3191278 479376..479843 1 NC_006570.2 Similar to Q8E8X2 RNA methyltransferase, TrmH family, group 2 from Shewanella oneidensis (154 aa). FASTA: opt: 569 Z-score: 759.8 E(): 2e-34 Smith-Waterman score: 569; 57.616 identity in 151 aa overlap; tRNA/rRNA methyltransferase 479843 yibK 3191278 yibK Francisella tularensis subsp. tularensis SCHU S4 tRNA/rRNA methyltransferase YP_169501.1 479376 D 177416 CDS YP_169502.1 56707606 3192351 479961..481025 1 NC_006570.2 Similar to ASG2_HAEIN (P43843) Probable L-asparaginase periplasmic [Precursor] from Haemophilus influenzae (349 aa). FASTA: opt: 897 Z-score: 1034.7 E(): 9.6e-50 Smith-Waterman score: 897; 43.966 identity in 348 aa overlap. No signal peptide predicted; periplasmic L-asparaginase II 481025 ansB 3192351 ansB Francisella tularensis subsp. tularensis SCHU S4 periplasmic L-asparaginase II YP_169502.1 479961 D 177416 CDS YP_169504.1 56707608 3190944 complement(481989..483734) 1 NC_006570.2 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 483734 argS 3190944 argS Francisella tularensis subsp. tularensis SCHU S4 arginyl-tRNA synthetase YP_169504.1 481989 R 177416 CDS YP_169505.1 56707609 3191215 483860..486466 1 NC_006570.2 Similar to OSTA_XYLFT (Q87AI9) Organic solvent tolerance protein from Xylella fastidiosa (792 aa). FASTA: opt: 700 Z-score: 808.7 E(): 3.7e-37 Smith-Waterman score: 775; 26.572 identity in 636 aa overlap; organic solvent tolerance protein 486466 ostA1 3191215 ostA1 Francisella tularensis subsp. tularensis SCHU S4 organic solvent tolerance protein YP_169505.1 483860 D 177416 CDS YP_169506.1 56707610 3190745 486448..487869 1 NC_006570.2 Similar to Q8ZIK4 Survival protein SurA (Peptidyl-prolyl cis-trans isomerase) from Yersinia pestis (434 aa). FASTA: opt: 532 Z-score: 586.9 E(): 8.4e-25 Smith-Waterman score: 532; 25.176 identity in 425 aa overlap; peptidyl-prolyl cis-trans isomerase 487869 surA 3190745 surA Francisella tularensis subsp. tularensis SCHU S4 peptidyl-prolyl cis-trans isomerase YP_169506.1 486448 D 177416 CDS YP_169507.1 56707611 3190742 487871..488659 1 NC_006570.2 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 488659 ksgA 3190742 ksgA Francisella tularensis subsp. tularensis SCHU S4 dimethyladenosine transferase YP_169507.1 487871 D 177416 CDS YP_169508.1 56707612 3192350 488671..489498 1 NC_006570.2 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 489498 apaH 3192350 apaH Francisella tularensis subsp. tularensis SCHU S4 diadenosine tetraphosphatase YP_169508.1 488671 D 177416 CDS YP_169509.1 56707613 3192548 489502..489939 1 NC_006570.2 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 489939 aroD 3192548 aroD Francisella tularensis subsp. tularensis SCHU S4 3-dehydroquinate dehydratase YP_169509.1 489502 D 177416 CDS YP_169510.1 56707614 3191467 489944..490417 1 NC_006570.2 Similar to BCCP_PSEAE (P37799) Biotin carboxyl carrier protein of acetyl-CoA carboxylase from Pseudomonas aeruginosa (156 aa). FASTA: opt: 466 Z-score: 537.8 E(): 4.6e-22 Smith-Waterman score: 466; 48.148 identity in 162 aa overlap; acetyl-Coa carboxylase biotin carboxyl carrier protein subunit 490417 accB 3191467 accB Francisella tularensis subsp. tularensis SCHU S4 acetyl-Coa carboxylase biotin carboxyl carrier protein subunit YP_169510.1 489944 D 177416 CDS YP_169511.1 56707615 3192529 490482..491837 1 NC_006570.2 Similar to Q9KV62 Acetyl-CoA carboxylase, biotin carboxylase subunit from Vibrio cholerae (447 aa). FASTA: opt: 2119 Z-score: 2505.5 E(): 1.2e-131 Smith-Waterman score: 2119; 70.270 identity in 444 aa overlap; acetyl-Coa carboxylase biotin carboxylase subunit 491837 accC 3192529 accC Francisella tularensis subsp. tularensis SCHU S4 acetyl-Coa carboxylase biotin carboxylase subunit YP_169511.1 490482 D 177416 CDS YP_169512.1 56707616 3191405 491931..492611 1 NC_006570.2 ORF ftt0474; hypothetical protein 492611 3191405 FTT_0474 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169512.1 491931 D 177416 CDS YP_169513.1 56707617 3191637 492637..493755 1 NC_006570.2 Similar to Q87G16 (Q87G16) membrane protein from Vibrio parahaemolyticus (365 aa). FASTA: opt: 362 Z-score: 432.0 E(): 3.6e-16 Smith-Waterman score: 412; 29.167 identity in 384 aa overlap; mechanosensitive ion channel MscS 493755 msc 3191637 msc Francisella tularensis subsp. tularensis SCHU S4 mechanosensitive ion channel MscS YP_169513.1 492637 D 177416 CDS YP_169514.1 56707618 3191874 complement(493760..494683) 1 NC_006570.2 Similar to Q83AR3 (Q83AR3) Lysyl-tRNA synthetase-related protein from Coxiella burnetii (321 aa). FASTA: opt: 727 Z-score: 890.9 E(): 9.9e-42 Smith-Waterman score: 727; 42.088 identity in 297 aa overlap; lysyl-tRNA synthetase 494683 poxA 3191874 poxA Francisella tularensis subsp. tularensis SCHU S4 lysyl-tRNA synthetase YP_169514.1 493760 R 177416 CDS YP_169515.1 56707619 3190970 complement(494680..495462) 1 NC_006570.2 Similar to Q83CV0 BirA bifunctional protein from Coxiella burnetii (323 aa). FASTA: opt: 375 Z-score: 457.7 E(): 1.3e-17 Smith-Waterman score: 375; 31.004 identity in 229 aa overlap; transcription repressor BirA 495462 birA 3190970 birA Francisella tularensis subsp. tularensis SCHU S4 transcription repressor BirA YP_169515.1 494680 R 177416 CDS YP_169516.1 56707620 3191636 complement(495459..497201) 1 NC_006570.2 Similar to RECJ_HAEIN (P45112) single-stranded-DNA-specific exonuclease from Haemophilus influenzae (575 aa). FASTA: opt: 869 Z-score: 996.6 E(): 1.3e-47 Smith-Waterman score: 902; 32.028identity in 562 aa overlap; single-stranded-DNA-specific exonuclease 497201 recJ 3191636 recJ Francisella tularensis subsp. tularensis SCHU S4 single-stranded-DNA-specific exonuclease YP_169516.1 495459 R 177416 CDS YP_169517.1 56707621 3191330 complement(497195..498301) 1 NC_006570.2 Similar to Q9I4W6 Hypothetical protein PA1007 from Pseudomonas aeruginosa (357 aa). FASTA: opt: 1016 Z-score: 1092.5 E(): 5.8e-53 Smith-Waterman score: 1016; 40.698 identity in 344 aa overlap; PerM family protein 498301 perM 3191330 perM Francisella tularensis subsp. tularensis SCHU S4 PerM family protein YP_169517.1 497195 R 177416 CDS YP_169518.1 56707622 3192117 complement(498403..499812) 1 NC_006570.2 Similar to Q8YBJ1 Glutamate:gamma-aminobutyrate antiporter from Brucella melitensis (510 aa). FASTA: opt: 983 Z-score: 1079.5 E(): 3.1e-52 Smith-Waterman score: 983; 34.698 identity in 464 aa overlap; glutamate:gamma-aminobutyric acid antiporter family protein 499812 xasA 3192117 xasA Francisella tularensis subsp. tularensis SCHU S4 glutamate:gamma-aminobutyric acid antiporter family protein YP_169518.1 498403 R 177416 CDS YP_169519.1 56707623 3191596 499896..501077 1 NC_006570.2 Similar to Q92RX4 Probable putrescine-binding periplasmic protein from Rhizobium meliloti (364 aa). FASTA: opt: 847 Z-score: 993.2 E(): 2e-47 Smith-Waterman score: 847; 35.714 identity in 350 aa overlap; putrescine-binding periplasmic protein 501077 potF 3191596 potF Francisella tularensis subsp. tularensis SCHU S4 putrescine-binding periplasmic protein YP_169519.1 499896 D 177416 CDS YP_169520.1 56707624 3191404 complement(501330..502145) 1 NC_006570.2 ORF ftt0482c; lipoprotein 502145 3191404 FTT_0482c Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_169520.1 501330 R 177416 CDS YP_169521.1 56707625 3191403 complement(502364..503251) 1 NC_006570.2 Similar to AAP95905 (AAP95905) Hypothetical protein from Haemophilus ducreyi 35000HP (342 aa). FASTA: opt: 686 Z-score: 815.5 E(): 1.6e-37 Smith-Waterman score: 686; 40.678 identity in 295 aa overlap ORF ftt0483c; hypothetical protein 503251 3191403 FTT_0483c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169521.1 502364 R 177416 CDS YP_169522.1 56707626 3191402 503405..504124 1 NC_006570.2 ORF ftt0484; hypothetical protein 504124 3191402 FTT_0484 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169522.1 503405 D 177416 CDS YP_169523.1 56707627 3191401 504192..504854 1 NC_006570.2 ORF ftt0485; hypothetical protein 504854 3191401 FTT_0485 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169523.1 504192 D 177416 CDS YP_169524.1 56707628 3192051 504862..506664 1 NC_006570.2 Similar to MUTL_RICPR (Q9ZC88) DNA mismatch repair protein mutL from Rickettsia prowazekii (595 aa). FASTA: opt: 1236 Z-score: 1435.6 E(): 4.5e-72 Smith-Waterman score: 1236; 37.291 identity in 598 aa overlap; DNA mismatch repair protein 506664 mutL 3192051 mutL Francisella tularensis subsp. tularensis SCHU S4 DNA mismatch repair protein YP_169524.1 504862 D 177416 CDS YP_169526.1 56707630 3191397 complement(507762..508895) 1 NC_006570.2 Similar to Q83BM0 Major facilitator family transporter from Coxiella burnetii (428 aa). FASTA: opt: 319 Z-score: E(): 3.7e-11 Smith-Waterman score: 319; 21.951 identity in 369 aa overlap ORF ftt0488c; major facilitator transporter 508895 3191397 FTT_0488c Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_169526.1 507762 R 177416 CDS YP_169527.1 56707631 3191000 complement(509037..509987) 1 NC_006570.2 Similar to Q8ZGC9 Thioredoxin reductase from Yersinia pestis (320 aa). FASTA: opt: 1525 Z-score: 1798.2 E(): 2.9e-92 Smith-Waterman score: 1525; 70.927 identity in 313 aa overlap; thioredoxin reductase 509987 trxB 3191000 trxB Francisella tularensis subsp. tularensis SCHU S4 thioredoxin reductase YP_169527.1 509037 R 177416 CDS YP_169528.1 56707632 3191396 complement(510079..511296) 1 NC_006570.2 Similar Q888K0 Phospholipase D family protein from Pseudomonas syringae (pv. tomato) (422 aa). FASTA: opt: 440 Z-score: 514.4 E(): 9.2e-21 Smith-Waterman score: 440; 25.840 identity in 387 aa overlap ORF ftt0490c; phospholipase D 511296 3191396 FTT_0490c Francisella tularensis subsp. tularensis SCHU S4 phospholipase D YP_169528.1 510079 R 177416 CDS YP_169529.1 56707633 3192528 complement(511339..512013) 1 NC_006570.2 Similar to Q82SZ4 Phosphoglycolate phosphatase from Nitrosomonas europaea (240 aa). FASTA: opt: 432 Z-score: 532.2 E(): 9.4e-22 Smith-Waterman score: 432; 33.486 identity in 218 aa overlap; phosphoglycolate phosphatase 512013 gph 3192528 gph Francisella tularensis subsp. tularensis SCHU S4 phosphoglycolate phosphatase YP_169529.1 511339 R 177416 CDS YP_169530.1 56707634 3190932 complement(512054..512980) 1 NC_006570.2 Similar to Q87J66 Transcriptional regulator, LysR family from Vibrio parahaemolyticus (311 aa). FASTA: opt: 675 Z-score: 768.6 E(): 6.4e-35 Smith-Waterman score: 675; 33.115 identity in 305 aa overlap; LysR family transcriptional regulator 512980 lysR 3190932 lysR Francisella tularensis subsp. tularensis SCHU S4 LysR family transcriptional regulator YP_169530.1 512054 R 177416 CDS YP_169531.1 56707635 3191903 complement(514279..515001) 1 NC_006570.2 Similar Q9CNA6 Hypothetical protein PM0526 from Pasteurella multocida (244 aa). FASTA: opt: 521 Z-score: 651.2 E(): 2.2e-28 Smith-Waterman score: 521; 40.175 identity in 229 aa overlap; CutC family protein 515001 cutC 3191903 cutC Francisella tularensis subsp. tularensis SCHU S4 CutC family protein YP_169531.1 514279 R 177416 CDS YP_169532.1 56707636 3191393 515334..515837 1 NC_006570.2 Similar to Q9K0Q8 Hypothetical protein NMB0526 from Neisseria meningitidis (serogroup B) (172 aa). FASTA: opt: 455 Z-score: 573.9 E(): 4.5e-24 Smith-Waterman score: 455; 42.353 identity in 170 aa overlap ORF ftt0495; hypothetical protein 515837 3191393 FTT_0495 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169532.1 515334 D 177416 CDS YP_169533.1 56707637 3191392 515843..516607 1 NC_006570.2 Similar to Q935B8 Hypothetical protein HCM2.0044c from Salmonella typhi (251 aa). FASTA: opt: 242 Z-score: 297.7 E(): 1.1e-08 Smith-Waterman score: 296; 28.000 identity in 250 aa overlap ORF ftt0496; hypothetical protein 516607 3191392 FTT_0496 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169533.1 515843 D 177416 CDS YP_169536.1 56707640 3191386 complement(520542..521582) 1 NC_006570.2 Similar to Q9I0I7 Hypothetical protein PA2651 from Pseudomonas aeruginosa (352 aa). FASTA: opt: 382 Z-score: 397.1 E(): 3.2e-14 Smith-Waterman score: 382; 26.686 identity in 341 aa overlap ORF ftt0501c; hypothetical protein 521582 3191386 FTT_0501c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169536.1 520542 R 177416 CDS YP_169537.1 56707641 3191385 complement(521966..522391) 1 NC_006570.2 ORF ftt0502c; hypothetical protein 522391 3191385 FTT_0502c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169537.1 521966 R 177416 CDS YP_169538.1 56707642 3190740 complement(522503..523375) 1 NC_006570.2 Similar to Q9JUS9 succinyl-CoA synthetase alpha from Neisseria meningitidis (serogroup A) (296 aa). FASTA: opt: 1574 Z-score: 1817.5 E(): 2.4e-93 Smith-Waterman score: 1574; 81.661identity in 289 aa overlap; succinyl-CoA synthetase subunit alpha 523375 sucD 3190740 sucD Francisella tularensis subsp. tularensis SCHU S4 succinyl-CoA synthetase subunit alpha YP_169538.1 522503 R 177416 CDS YP_169539.1 56707643 3190738 complement(523407..524570) 1 NC_006570.2 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 524570 sucC 3190738 sucC Francisella tularensis subsp. tularensis SCHU S4 succinyl-CoA synthetase subunit beta YP_169539.1 523407 R 177416 CDS YP_169540.1 56707644 3191381 524740..526653 1 NC_006570.2 ORF ftt0505; hypothetical protein 526653 3191381 FTT_0505 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169540.1 524740 D 177416 CDS YP_169541.1 56707645 3191384 complement(526661..526975) 1 NC_006570.2 ORF ftt0506c; hypothetical protein 526975 3191384 FTT_0506c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169541.1 526661 R 177416 CDS YP_169542.1 56707646 3191382 527634..528401 1 NC_006570.2 Similar to Q9X610 BcfH from Salmonella typhimurium (269 aa). FASTA: opt: 305 Z-score: 371.4 E(): 8.5e-13 Smith-Waterman score: 305; 31.122 identity in 196 aa overlap ORF ftt0507; lipoprotein 528401 3191382 FTT_0507 Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_169542.1 527634 D 177416 CDS YP_169543.1 56707647 3191548 complement(528408..529391) 1 NC_006570.2 Similar to Y926_SYNY3 (P72872) Hypothetical protein sll0926 from Synechocystis sp. (strain PCC 6803) (334 aa). FASTA: opt: 1129 Z-score: 1337.0 E(): 1.4e-66 Smith-Waterman score: 1129; 51.911 identity in 314 aa overlap; tRNA-dihydrouridine synthase A 529391 dusA 3191548 dusA Francisella tularensis subsp. tularensis SCHU S4 tRNA-dihydrouridine synthase A YP_169543.1 528408 R 177416 CDS YP_169544.1 56707648 3191380 complement(529425..530225) 1 NC_006570.2 Similar to Q8DBN3 Conserved hypothetical protein from Vibrio vulnificus (184 aa). FASTA: opt: 275 Z-score: 356.8 E(): 5.5e-12 Smith-Waterman score: 275; 30.208 identity in 192 aa overlap ORF ftt0509c; hypothetical protein 530225 3191380 FTT_0509c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169544.1 529425 R 177416 CDS YP_169545.1 56707649 3192346 530401..532818 1 NC_006570.2 Similar to GYRB_SALTY (Q60008) DNA gyrase subunit B from Salmonella typhimurium (803 aa). FASTA: opt: 3370 Z-score: 3873.3 E(): 7.5e-208 Smith-Waterman score: 3370; 63.321 identity in 807 aa overlap; DNA gyrase subunit B 532818 gyrB 3192346 gyrB Francisella tularensis subsp. tularensis SCHU S4 DNA gyrase subunit B YP_169545.1 530401 D 177416 CDS YP_169546.1 56707650 3191379 532948..533811 1 NC_006570.2 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 533811 3191379 FTT_0511 Francisella tularensis subsp. tularensis SCHU S4 pyridoxal biosynthesis lyase PdxS YP_169546.1 532948 D 177416 CDS YP_169547.3 255961456 3191376 533805..534353 1 NC_006570.2 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 534353 3191376 FTT_0512 Francisella tularensis subsp. tularensis SCHU S4 glutamine amidotransferase subunit PdxT YP_169547.3 533805 D 177416 CDS YP_169548.1 56707652 3190798 complement(join(534457..534915,534915..535241)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 535241 isftu1 3190798 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169548.1 534457 R 177416 CDS YP_169549.1 56707653 3191377 536458..536634 1 NC_006570.2 ORF ftt0515; hypothetical protein 536634 3191377 FTT_0515 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169549.1 536458 D 177416 CDS YP_169550.1 56707654 3191234 541312..542157 1 NC_006570.2 Similar to Q9CLW2 PrmA (Ribosomal protein L11 methyltransferase) from Pasteurella multocida (293 aa). FASTA: opt: 572 Z-score: 685.5 E(): 2.7e-30 Smith-Waterman score: 580; 33.677 identity in 291 aa overlap; 50S ribosomal protein L11 methyltransferase 542157 prmA 3191234 prmA Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L11 methyltransferase YP_169550.1 541312 D 177416 CDS YP_169551.1 56707655 3191226 542147..543130 1 NC_006570.2 Similar to Q9KGG5 Transcriptional regulator involved in nitrogen regulation, NifR3/Smm1 family from Bacillus halodurans (334 aa). FASTA: opt: 1134 Z-score: 1336.1 E(): 1.6e-66 Smith-Waterman score: 1134; 52.484 identity in 322 aa overlap ORF ftt0519; Nif3 family protein 543130 3191226 FTT_0519 Francisella tularensis subsp. tularensis SCHU S4 Nif3 family protein YP_169551.1 542147 D 177416 CDS YP_169554.1 56707658 3191219 545582..546808 1 NC_006570.2 Similar to Q89Z57 Type I restriction enzyme EcoAI specificity protein from Bacteroides thetaiotamicron (474 aa). FASTA: opt: 208 Z-score: 239.0 E(): 2e-05 Smith-Waterman score: 246; 24.363 identity in 353 aa overlap ORF ftt0523; hypothetical protein 546808 3191219 FTT_0523 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169554.1 545582 D 177416 CDS YP_169555.1 56707659 3191220 547050..547436 1 NC_006570.2 Similar to Q8KBB0 Hypothetical protein CT1879 from Chlorobium tepidum (193 aa). FASTA: opt: 467 Z-score: 629.2 E(): 3.7e-27 Smith-Waterman score: 467; 60.656 identity in 122 aa overlap ORF ftt0524; hypothetical protein 547436 3191220 FTT_0524 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169555.1 547050 D 177416 CDS YP_169556.1 56707660 3191218 547483..548139 1 NC_006570.2 Similar to RA50_THEVO DNA double-strand break repair rad50 ATPase from Thermoplasma volcanicum (895 aa). FASTA: opt: 188 Z-score: 215.6 E(): 0.0004 Smith-Waterman score: 188; 25.926 identity in 216 aa overlap. Similarity to N terminal domain ORF ftt0525; hypothetical protein 548139 3191218 FTT_0525 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169556.1 547483 D 177416 CDS YP_169557.1 56707661 3191216 548145..548351 1 NC_006570.2 ORF ftt0526; hypothetical protein 548351 3191216 FTT_0526 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169557.1 548145 D 177416 CDS YP_169560.1 56707664 3191211 complement(550624..551226) 1 NC_006570.2 Similar to Q97FB4 Intracellular protease/amidase related enzyme from Clostridium acetobutylicum (201 aa). FASTA: opt: 703 Z-score: 884.5 E(): 2.2e-41 Smith-Waterman score: 703; 51.531 identity in 196 aa overlap ORF ftt0530c; DJ-1/PfpI family protein 551226 3191211 FTT_0530c Francisella tularensis subsp. tularensis SCHU S4 DJ-1/PfpI family protein YP_169560.1 550624 R 177416 CDS YP_169561.1 56707665 3191711 complement(553228..554460) 1 NC_006570.2 Similar to (glutaredoxin 3) Q8ZJM8 Glutaredoxin 3 from Yersinia pestis (82 aa). FASTA: opt: 181 Z-score: 263.7 E(): 8.5e-07 Smith-Waterman score: 181; 40.260 identity in 77 aa overlap,(ribonucleoside-diphosphate reductase) Q8QYZ8 Ribonucleoside-diphosphate reductase, beta subunit-like protein from Rana tigrina ranavirus (387 aa). FASTA: opt: 1124 Z-score: 1382.6 E(): 4.1e-69 Smith-Waterman score: 1124; 51.703 identity in 323 aa overlap; bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta 554460 grxC 3191711 grxC Francisella tularensis subsp. tularensis SCHU S4 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta YP_169561.1 553228 R 177416 CDS YP_169562.1 56707666 3192520 complement(554467..554727) 1 NC_006570.2 Similar to GLR1_ECOLI (P00277) Glutaredoxin 1 from Escherichia coli (85 aa). FASTA: opt: 191 Z-score: 274.9 E(): 2e-07 Smith-Waterman score: 191; 40.000identity in 80 aa overlap; glutaredoxin 554727 grxA 3192520 grxA Francisella tularensis subsp. tularensis SCHU S4 glutaredoxin YP_169562.1 554467 R 177416 CDS YP_169563.1 56707667 3191708 complement(554731..556503) 1 NC_006570.2 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 556503 nrdA 3191708 nrdA Francisella tularensis subsp. tularensis SCHU S4 ribonucleotide-diphosphate reductase subunit alpha YP_169563.1 554731 R 177416 CDS YP_169564.1 56707668 3191869 complement(556707..557666) 1 NC_006570.2 Catalyzes the reversible oxidation of malate to oxaloacetate; malate dehydrogenase 557666 mdh 3191869 mdh Francisella tularensis subsp. tularensis SCHU S4 malate dehydrogenase YP_169564.1 556707 R 177416 CDS YP_169565.1 56707669 3191210 557814..558329 1 NC_006570.2 ORF ftt0536; hypothetical protein 558329 3191210 FTT_0536 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169565.1 557814 D 177416 CDS YP_169566.1 56707670 3191209 558345..558980 1 NC_006570.2 Similar to Q8PD67 Ubiquinone biosynthesis protein from Xanthomonas campestris (217 aa). FASTA: opt: 710 Z-score: 878.4 E(): 4.9e-41 Smith-Waterman score: 710; 51.887 identity in 212 aa overlap (2-211:8-217) ORF ftt0537; ubiquinone biosynthesis protein 558980 3191209 FTT_0537 Francisella tularensis subsp. tularensis SCHU S4 ubiquinone biosynthesis protein YP_169566.1 558345 D 177416 CDS YP_169567.1 56707671 3191206 complement(558989..559558) 1 NC_006570.2 Similar to Q87LS3 Hypothetical protein from Vibrio parahaemolyticus (203 aa). FASTA: opt: 267 Z-score: 350.1 E(): 1.3e-11 Smith-Waterman score: 320; 31.795 identity in 195 aa overlap ORF ftt0538c; lipoprotein 559558 3191206 FTT_0538c Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_169567.1 558989 R 177416 CDS YP_169568.1 56707672 3191205 complement(560383..561873) 1 NC_006570.2 ORF ftt0540c; hypothetical protein 561873 3191205 FTT_0540c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169568.1 560383 R 177416 CDS YP_169569.1 56707673 3192402 complement(561928..562527) 1 NC_006570.2 Similar to YQAB_ECOLI (P77475) Hypothetical protein yqaB from Escherichia coli (188 aa). FASTA: opt: 336 Z-score: 422.2 E(): 1.3e-15 Smith-Waterman score: 336; 33.889 identity in 180 aa overlap; haloacid dehalogenase 562527 yqaB 3192402 yqaB Francisella tularensis subsp. tularensis SCHU S4 haloacid dehalogenase YP_169569.1 561928 R 177416 CDS YP_169570.1 56707674 3191204 563268..564644 1 NC_006570.2 ORF ftt0543; hypothetical protein 564644 3191204 FTT_0543 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169570.1 563268 D 177416 CDS YP_169571.1 56707675 3191136 564750..565082 1 NC_006570.2 Similar to PHNA_ECOLI PhnA protein from Escherichia coli (111 aa). FASTA: opt: 521 Z-score: 674.6 E(): 1.1e-29 Smith-Waterman score: 521; 66.972identity in 109 aa overlap; phosphonoacetate hydrolase 565082 phnA 3191136 phnA Francisella tularensis subsp. tularensis SCHU S4 phosphonoacetate hydrolase YP_169571.1 564750 D 177416 CDS YP_169572.1 56707676 3191203 565088..565303 1 NC_006570.2 ORF ftt0545; hypothetical protein 565303 3191203 FTT_0545 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169572.1 565088 D 177416 CDS YP_169573.1 56707677 3191202 565307..565918 1 NC_006570.2 ORF ftt0546; hypothetical protein 565918 3191202 FTT_0546 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169573.1 565307 D 177416 CDS YP_169575.1 56707679 3191535 566858..567550 1 NC_006570.2 Similar to Q83EK2 DNA polymerase III, epsilon subunit from Coxiella burnetii (232 aa). FASTA: opt: 699 Z-score: 870.8 E(): 1.3e-40 Smith-Waterman score: 699; 49.550 identity in 222 aa overlap; DNA polymerase III subunit epsilon 567550 dnaQ 3191535 dnaQ Francisella tularensis subsp. tularensis SCHU S4 DNA polymerase III subunit epsilon YP_169575.1 566858 D 177416 CDS YP_169576.1 56707680 3191938 567544..568017 1 NC_006570.2 Similar to Q87AM4 Peptidase (202 aa). FASTA: opt: 481 Z-score: 603.7 E(): 9.8e-26 Smith-Waterman score: 481; 50.000 identity in 142 aa overlap; D-alanyl-D-alanine carboxypeptidase 568017 vanY 3191938 vanY Francisella tularensis subsp. tularensis SCHU S4 D-alanyl-D-alanine carboxypeptidase YP_169576.1 567544 D 177416 CDS YP_169577.1 56707681 3191200 567977..569413 1 NC_006570.2 Similar to Q8EHZ3 TPR domain protein from Shewanella oneidensis (466 aa). FASTA: opt: 304 Z-score: 346.2 E(): 2.2e-11 Smith-Waterman score: 331; 23.333 identity) in 480 aa overlap ORF ftt0550; hypothetical protein 569413 3191200 FTT_0550 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169577.1 567977 D 177416 CDS YP_169578.1 56707682 3191197 570846..572342 1 NC_006570.2 Similar to Q8P9Q7 Aldehyde dehydrogenase from Xanthomonas campestris (510 aa). FASTA: opt: 1972 Z-score: 2329.9 E(): 6.9e-122 Smith-Waterman score: 1972; 60.285 identity in 491 aa overlap ORF ftt0552; aldehyde dehydrogenase 572342 3191197 FTT_0552 Francisella tularensis subsp. tularensis SCHU S4 aldehyde dehydrogenase YP_169578.1 570846 D 177416 CDS YP_169579.1 56707683 3191762 572347..573126 1 NC_006570.2 Similar to Q8EJ53 Conserved hypothetical protein from Shewanella oneidensis (267 aa). FASTA: opt: 859 Z-score: 1057.9 E(): 4.9e-51 Smith-Waterman score: 859; 52.809 identity in 267 aa overlap ORF ftt0553; hypothetical protein 573126 3191762 FTT_0553 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169579.1 572347 D 177416 CDS YP_169580.1 56707684 3191196 573210..573482 1 NC_006570.2 Similar to Q99SH0 Hypothetical protein SAV2087 from Stafylococcus aureus (97 aa). FASTA: opt: 243 Z-score: 331.6 E(): 1.4e-10 Smith-Waterman score: 243; 45.455 identity in 77 aa overlap ORF ftt0554; hypothetical protein 573482 3191196 FTT_0554 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169580.1 573210 D 177416 CDS YP_169581.1 56707685 3191193 573496..574227 1 NC_006570.2 Similar to Q930P5 Hypothetical protein RA0150 from Rhizobium meliloti (262 aa). FASTA: opt: 924 Z-score: 1048.2 E(): 1.7e-50 Smith-Waterman score: 924; 54.202 identity in 238 aa overlap. Some similarity to glutaredoxin ORF ftt0555; hypothetical protein 574227 3191193 FTT_0555 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169581.1 573496 D 177416 CDS YP_169582.1 56707686 3191225 complement(574230..575099) 1 NC_006570.2 Similar to O06466 Oxidative stress transcriptional regulator from Xanthomonas campestris (313 aa). FASTA: opt: 707 Z-score: 842.2 E(): 5.1e-39 Smith-Waterman score: 707; 36.207 identity in 290 aa overlap; oxidative stress transcriptional regulator 575099 oxyR 3191225 oxyR Francisella tularensis subsp. tularensis SCHU S4 oxidative stress transcriptional regulator YP_169582.1 574230 R 177416 CDS YP_169583.1 56707687 3191195 575197..575721 1 NC_006570.2 Similar to Q92MY1 Hypothetical protein R02467 from Rhizobium meliloti (180 aa). FASTA: opt: 821 Z-score: 1055.0 E(): 7.2e-51 Smith-Waterman score: 821; 66.092 identity in 174 aa overlap ORF ftt0557; AhpC/TSA family protein 575721 3191195 FTT_0557 Francisella tularensis subsp. tularensis SCHU S4 AhpC/TSA family protein YP_169583.1 575197 D 177416 CDS YP_169584.1 56707688 3191194 575724..576335 1 NC_006570.2 Similar to Q8XU62 Hypothetical protein RSc3331 from Ralstonia solanacearum (201 aa). FASTA: opt: 602 Z-score: 724.0 E(): 2e-32 Smith-Waterman score: 602; 48.020 identity in 202 aa overlap ORF ftt0558; short chain dehydrogenase 576335 3191194 FTT_0558 Francisella tularensis subsp. tularensis SCHU S4 short chain dehydrogenase YP_169584.1 575724 D 177416 CDS YP_169585.1 56707689 3192510 complement(576352..577017) 1 NC_006570.2 Similar to KCY_PASMU (P57875) Cytidylate kinase from Pasteurella multocida (227 aa). FASTA: opt: 748 Z-score: 879.9 E(): 4.1e-41 Smith-Waterman score: 748; 53.425 identity in 219 aa overlap; cytidylate kinase 577017 cmk 3192510 cmk Francisella tularensis subsp. tularensis SCHU S4 cytidylate kinase YP_169585.1 576352 R 177416 CDS YP_169586.1 56707690 3190960 complement(577004..578056) 1 NC_006570.2 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 578056 serC 3190960 serC Francisella tularensis subsp. tularensis SCHU S4 phosphoserine aminotransferase YP_169586.1 577004 R 177416 CDS YP_169587.1 56707691 3190912 join(578376..578702,578702..579160) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 579160 isftu1 3190912 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169587.1 578376 D 177416 CDS YP_169588.1 56707692 3191563 579542..580663 1 NC_006570.2 Similar to Q8EHF2 Polyamine ABC transporter, ATP-binding protein from Shewanella oneidensis (378 aa). FASTA: opt: 1366 Z-score: 1557.5 E(): 7.3e-79 Smith-Waterman score: 1366; 55.496 identity in 373 aa overlap; polyamine transporter ABC transporter ATP-binding protein 580663 potG 3191563 potG Francisella tularensis subsp. tularensis SCHU S4 polyamine transporter ABC transporter ATP-binding protein YP_169588.1 579542 D 177416 CDS YP_169589.1 56707693 3190974 580627..581544 1 NC_006570.2 Similar to Q8FJE8 Putrescine transport system permease protein from Escherichia coli (314 aa). FASTA: opt: 949 Z-score: 1040.4 E(): 4.7e-50 Smith-Waterman score: 949; 43.878 identity in 294 aa overlap; polyamine transporter ABC transporter membrane protein 581544 potH 3190974 potH Francisella tularensis subsp. tularensis SCHU S4 polyamine transporter ABC transporter membrane protein YP_169589.1 580627 D 177416 CDS YP_169590.1 56707694 3191478 581558..582364 1 NC_006570.2 Similar to Q8EHF0 Polyamine ABC transporter, permease protein from Shewanella oneidensis (271 aa). FASTA: opt: 873 Z-score: 1010.7 E(): 2.1e-48 Smith-Waterman score: 873; 46.241 identity in 266 aa overlap; polyamine transporter ABC transporter membrane protein 582364 potI 3191478 potI Francisella tularensis subsp. tularensis SCHU S4 polyamine transporter ABC transporter membrane protein YP_169590.1 581558 D 177416 CDS YP_169591.1 56707695 3190925 complement(582508..583251) 1 NC_006570.2 ISFtu2. Transposase, member of the IS5 family. Identical to Q8GM03 transposase from Francisella tularensis (247 aa).; transposase 583251 isftu2 3190925 isftu2 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169591.1 582508 R 177416 CDS YP_169592.1 56707696 3191192 583397..583663 1 NC_006570.2 ORF ftt0566; hypothetical protein 583663 3191192 FTT_0566 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169592.1 583397 D 177416 CDS YP_169593.1 56707697 3191190 585869..586519 1 NC_006570.2 Similar to Q26545 Phosphoserine phosphohydrolase-like protein trans-spliced from Schistosoma mansoni (223 aa). FASTA: opt: 319 Z-score: 380.8 E(): 2.5e-13 Smith-Waterman score: 319; 29.493 identity in 217 aa overlap. Similar to eukaryotic proteins. Historical HGT-event? ORF ftt0568; hypothetical protein 586519 3191190 FTT_0568 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169593.1 585869 D 177416 CDS YP_169594.1 56707698 3191188 complement(586508..587530) 1 NC_006570.2 Similar to Q8P3T2 Integral membrane protein from Xanthomonas campestris (347 aa). FASTA: opt: 906 Z-score: 1071.1 E(): 9e-52 Smith-Waterman score: 906; 41.739 identity in 345 aa overlap ORF ftt0569c; hypothetical protein 587530 3191188 FTT_0569c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169594.1 586508 R 177416 CDS YP_169595.1 56707699 3191186 587610..588008 1 NC_006570.2 ORF ftt0570; hypothetical protein 588008 3191186 FTT_0570 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169595.1 587610 D 177416 CDS YP_169596.1 56707700 3191185 588020..588727 1 NC_006570.2 Partially similar to Q96F61 Hypothetical protein from Homo sapiens (409 aa). FASTA: opt: 403 Z-score: 516.3 E(): 7.3e-21 Smith-Waterman score: 403; 34.171 identity in 199 aa overlap ORF ftt0571; hypothetical protein 588727 3191185 FTT_0571 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169596.1 588020 D 177416 CDS YP_169597.1 56707701 3191184 588852..590306 1 NC_006570.2 Similar to Q8Z269 PTR2 family transport protein from Salmonella typhi (489 aa). FASTA: opt: 729 Z-score: 778.1 E(): 1.9e-35 Smith-Waterman score: 770; 30.524identity in 439 aa overlap ORF ftt0572; proton-dependent oligopeptide transport (POT) family protein 590306 3191184 FTT_0572 Francisella tularensis subsp. tularensis SCHU S4 proton-dependent oligopeptide transport (POT) family protein YP_169597.1 588852 D 177416 CDS YP_169598.1 56707702 3192353 590357..591454 1 NC_006570.2 Similar to Q81EB9 Alanine racemase from Bacillus cereus (408 aa). FASTA: opt: 573 Z-score: 679.1 E(): 6.2e-30 Smith-Waterman score: 573; 29.863 identity in 365 aa overlap; alanine racemase 591454 alr 3192353 alr Francisella tularensis subsp. tularensis SCHU S4 alanine racemase YP_169598.1 590357 D 177416 CDS YP_169599.1 56707703 3191368 593229..594071 1 NC_006570.2 Similar to Q8KBW6 Prephenate dehydratase from chlorobium tepidum (280 aa). FASTA: opt: 624 Z-score: 792.7 E(): 2.9e-36 Smith-Waterman score: 624; 38.489 identity in 278 aa overlap; prephenate dehydratase 594071 pheA 3191368 pheA Francisella tularensis subsp. tularensis SCHU S4 prephenate dehydratase YP_169599.1 593229 D 177416 CDS YP_169600.1 56707704 3191182 594097..594765 1 NC_006570.2 Similar to Q894N2 zinc metallopeptidase from Clostridium tetani (236 aa). FASTA: opt: 434 Z-score: 526.0 E(): 2.1e-21 Smith-Waterman score: 434; 36.245 identity in 229 aa overlap ORF ftt0576; hypothetical protein 594765 3191182 FTT_0576 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169600.1 594097 D 177416 CDS YP_169601.1 56707705 3192275 594821..596194 1 NC_006570.2 Similar to Q8EEW4 L-serine dehydratase 1 from Shewanella oneidensis (458 aa). FASTA: opt: 1442 Z-score: 1806.4 E(): 1e-92 Smith-Waterman score: 1442; 48.922 identity in 464 aa overlap; L-serine dehydratase 1 596194 sdaA 3192275 sdaA Francisella tularensis subsp. tularensis SCHU S4 L-serine dehydratase 1 YP_169601.1 594821 D 177416 CDS YP_169602.1 56707706 3191895 596297..597520 1 NC_006570.2 Similar to Q8ZDZ4 selenocysteine lyase from Yersinia pestis (406 aa). FASTA: opt: 1343 Z-score: 1645.0 E(): 9.9e-84 Smith-Waterman score: 1343; 48.507 identity in 402 aa overlap; selenocysteine lyase 597520 csdB 3191895 csdB Francisella tularensis subsp. tularensis SCHU S4 selenocysteine lyase YP_169602.1 596297 D 177416 CDS YP_169603.1 56707707 3191180 597541..597897 1 NC_006570.2 Similar to AAP95950 HesB family protein from Haemophilus ducreyi (107 aa). FASTA: opt: 288 Z-score: 392.8 E(): 5.5e-14 Smith-Waterman score: 288; 41.121 identity in 107 aa overlap ORF ftt0579; HesB family protein 597897 3191180 FTT_0579 Francisella tularensis subsp. tularensis SCHU S4 HesB family protein YP_169603.1 597541 D 177416 CDS YP_169604.1 56707708 3191179 597911..598462 1 NC_006570.2 Similar to Q83BY3 Hypothetical protein from Coxiella burnetii (180 aa). FASTA: opt: 593 Z-score: 750.6 E(): 6.4e-34 Smith-Waterman score: 593; 48.045 identity in 179 aa overlap ORF ftt0580; hypothetical protein 598462 3191179 FTT_0580 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169604.1 597911 D 177416 CDS YP_169605.1 56707709 3192516 598474..598962 1 NC_006570.2 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 598962 coaD 3192516 coaD Francisella tularensis subsp. tularensis SCHU S4 phosphopantetheine adenylyltransferase YP_169605.1 598474 D 177416 CDS YP_169606.1 56707710 3191881 598967..599212 1 NC_006570.2 ferredoxin. Identical to Q47937 Ferredoxin from Francisella novicida. Similar to Q88AH4 Ferredoxin from pseudomonas syringae (83 aa). FASTA: opt: 431 Z-score: 563.2 E(): 1.8e-23 Smith-Waterman score: 431; 65.432 identity in 81 aa overlap; ferredoxin 599212 fdx 3191881 fdx Francisella tularensis subsp. tularensis SCHU S4 ferredoxin YP_169606.1 598967 D 177416 CDS YP_169607.1 56707711 3192005 599319..600500 1 NC_006570.2 No transmembrane helix predicted.; outer membrane associated protein 600500 fopA1 3192005 fopA1 Francisella tularensis subsp. tularensis SCHU S4 outer membrane associated protein YP_169607.1 599319 D 177416 CDS YP_169608.1 56707712 3191177 601162..604533 1 NC_006570.2 ORF ftt0584; hypothetical protein 604533 3191177 FTT_0584 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169608.1 601162 D 177416 CDS YP_169609.1 56707713 3191175 605902..606480 1 NC_006570.2 Similar to Q9YCL9 Hypothetical protein APE1239 from Aeropyrum pernix (221 aa). FASTA: opt: 238 Z-score: 303.8 E(): 5e-09 Smith-Waterman score: 238; 25.683 identity in 183 aa overlap. Weakly conserved. ORF ftt0586; hypothetical protein 606480 3191175 FTT_0586 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169609.1 605902 D 177416 CDS YP_169610.1 56707714 3190840 complement(606904..607647) 1 NC_006570.2 ISFtu2. Transposase, member of the IS5 family. Identical to Q8GM03 transposase from Francisella tularensis (247 aa).; transposase 607647 isftu2 3190840 isftu2 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169610.1 606904 R 177416 CDS YP_169611.1 56707715 3191078 607810..609087 1 NC_006570.2 Similar to AROA_VIBPA (Q87QX9) 3-phosphoshikimate 1-carboxyvinyltransferase from Vibrio parahaemolyticus (426 aa). FASTA: opt: 928 Z-score: 1157.4 E(): 1.4e-56 Smith-Waterman score: 928; 36.916 identity in 428 aa overlap; 3-phosphoshikimate 1-carboxyvinyltransferase 609087 aroA 3191078 aroA Francisella tularensis subsp. tularensis SCHU S4 3-phosphoshikimate 1-carboxyvinyltransferase YP_169611.1 607810 D 177416 CDS YP_169612.1 56707716 3191174 609090..609680 1 NC_006570.2 ORF ftt0589; hypothetical protein 609680 3191174 FTT_0589 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169612.1 609090 D 177416 CDS YP_169613.1 56707717 3191605 609631..610113 1 NC_006570.2 Similar to RNH_PSEAE (Q9I2S9) Ribonuclease H from Pseudomonas aeruginosa (148 aa). FASTA: opt: 673 Z-score: 830.4 E(): 2.3e-38 Smith-Waterman score: 673; 62.937 identity in 143 aa overlap; ribonuclease H 610113 rnhA 3191605 rnhA Francisella tularensis subsp. tularensis SCHU S4 ribonuclease H YP_169613.1 609631 D 177416 CDS YP_169614.1 56707718 3192357 610115..611152 1 NC_006570.2 Similar to Q8EEG1 L-asparaginase I from Shewanella oneidensis (337 aa). FASTA: opt: 1041 Z-score: 1293.4 E(): 3.7e-64 Smith-Waterman score: 1041; 49.258identity in 337 aa overlap; L-asparaginase 611152 ansA 3192357 ansA Francisella tularensis subsp. tularensis SCHU S4 L-asparaginase YP_169614.1 610115 D 177416 CDS YP_169615.1 56707719 3191916 611223..611909 1 NC_006570.2 Similar to Q87AM3 Carbonic anhydrase from xylella fastidiosa (220 aa). FASTA: opt: 577 Z-score: 733.9 E(): 5.5e-33 Smith-Waterman score: 722; 45.536 identity in 224 aa overlap; carbonic anhydrase 611909 cynT 3191916 cynT Francisella tularensis subsp. tularensis SCHU S4 carbonic anhydrase YP_169615.1 611223 D 177416 CDS YP_169616.1 56707720 3191172 complement(612196..612801) 1 NC_006570.2 ORF ftt0593c; hypothetical protein 612801 3191172 FTT_0593c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169616.1 612196 R 177416 CDS YP_169617.1 56707721 3191171 complement(612865..613737) 1 NC_006570.2 Similar to Q87N89 Hypothetical protein from Vibrio parahaemolyticus (344 aa). FASTA: opt: 706 Z-score: 859.6 E(): 5.5e-40 Smith-Waterman score: 706; 42.160 identity in 287 aa overlap ORF ftt0594c; hypothetical protein 613737 3191171 FTT_0594c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169617.1 612865 R 177416 CDS YP_169618.1 56707722 3191088 complement(613746..613916) 1 NC_006570.2 Similar to Q88C68 Rubredoxin from Pseudomonas putida (55 aa). FASTA: opt: 334 Z-score: 465.9 E(): 4.6e-18 Smith-Waterman score: 334; 78.431 identity in 51 aa overlap; rubredoxin 613916 rubA 3191088 rubA Francisella tularensis subsp. tularensis SCHU S4 rubredoxin YP_169618.1 613746 R 177416 CDS YP_169619.1 56707723 3191170 complement(614003..614620) 1 NC_006570.2 ORF ftt0596c; hypothetical protein 614620 3191170 FTT_0596c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169619.1 614003 R 177416 CDS YP_169620.1 56707724 3191169 614732..616126 1 NC_006570.2 Similar to Q9K5Z6 Hypothetical UPF0061 protein BH393 from Bacillus halodurans (492 aa). FASTA: opt: 1251 Z-score: 1519.2 E(): 1e-76 Smith-Waterman score: 1357; 48.233 identity in 481 aa overlap ORF ftt0597; hypothetical protein 616126 3191169 FTT_0597 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169620.1 614732 D 177416 CDS YP_169621.1 56707725 3191168 complement(616158..617438) 1 NC_006570.2 Similar to Q8XLU3 Probable transmembrane symporter from Clostridium perfringens (435 aa). FASTA: opt: 881 Z-score: 961.9 E(): 1.1e-45 Smith-Waterman score: 881; 33.721identity in 430 aa overlap ORF ftt0598c; sodium-dicarboxylate symporter family protein 617438 3191168 FTT_0598c Francisella tularensis subsp. tularensis SCHU S4 sodium-dicarboxylate symporter family protein YP_169621.1 616158 R 177416 CDS YP_169622.1 56707726 3191165 617634..618662 1 NC_006570.2 Similar to Q9AAR1 SIS domain protein from Caulobacter crescentus (358 aa). FASTA: opt: 864 Z-score: 1052.1 E(): 1e-50 Smith-Waterman score: 864; 42.353 identity in 340 aa overlap. Glucosamine-fructose-6-phosphate aminotransferase ORF ftt0599; SIS domain-containing protein 618662 3191165 FTT_0599 Francisella tularensis subsp. tularensis SCHU S4 SIS domain-containing protein YP_169622.1 617634 D 177416 CDS YP_169623.1 56707727 3191164 620247..620366 1 NC_006570.2 ORF ftt0601; hypothetical protein 620366 3191164 FTT_0601 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169623.1 620247 D 177416 CDS YP_169624.1 56707728 3191163 complement(620993..622471) 1 NC_006570.2 ORF ftt0602c; hypothetical protein 622471 3191163 FTT_0602c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169624.1 620993 R 177416 CDS YP_169625.1 56707729 3191162 623031..623210 1 NC_006570.2 ORF ftt0603; hypothetical protein 623210 3191162 FTT_0603 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169625.1 623031 D 177416 CDS YP_169626.1 56707730 3191159 623728..624162 1 NC_006570.2 Similar to Q9CNR2 NhaP NA+/H+ antiporter Conserved hypothetical membrane protein from Pasteurella multocida (441 aa). FASTA: opt: 315 Z-score: 391.3 E(): 6.6e-14 Smith-Waterman score: 315; 39.850 identity in 133 aa overlap. Matches to a central part of an Nhap protein ORF ftt0604; hypothetical protein 624162 3191159 FTT_0604 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169626.1 623728 D 177416 CDS YP_169627.1 56707731 3191160 complement(624348..624536) 1 NC_006570.2 ORF ftt0605c; hypothetical protein 624536 3191160 FTT_0605c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169627.1 624348 R 177416 CDS YP_169628.1 56707732 3190876 625340..626557 1 NC_006570.2 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 626557 ispG 3190876 ispG Francisella tularensis subsp. tularensis SCHU S4 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_169628.1 625340 D 177416 CDS YP_169629.1 56707733 3191157 626572..627150 1 NC_006570.2 Similar to Q9KHC2 Hypothetical 27.0 kDa protein from secondary endosymbiont of Glycaspis brimblecombei (244 aa). FASTA: opt: 467 Z-score: 605.3 E(): 8e-26 Smith-Waterman score: 467; 44.751identity in 181 aa overlap ORF ftt0608; hypothetical protein 627150 3191157 FTT_0608 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169629.1 626572 D 177416 CDS YP_169630.1 56707734 3191155 627301..629094 1 NC_006570.2 Similar to Q83F75 Peptidase, M24 family protein from Coxiella burnetii (597 aa). FASTA: opt: 1665 Z-score: 1963.9 E(): 1.7e-101 Smith-Waterman score: 1665; 45.286 identity in 594 aa overlap ORF ftt0609; peptidase M24 family protein 629094 3191155 FTT_0609 Francisella tularensis subsp. tularensis SCHU S4 peptidase M24 family protein YP_169630.1 627301 D 177416 CDS YP_169631.1 56707735 3191154 629192..630256 1 NC_006570.2 Similar to Q8DFB3 DNA/RNA endonuclease G from Vibrio vulnificus (247 aa). FASTA: opt: 682 Z-score: 838.7 E(): 8e-39 Smith-Waterman score: 682; 46.311 identity in 244 aa overlap ORF ftt0610; DNA/RNA endonuclease family protein 630256 3191154 FTT_0610 Francisella tularensis subsp. tularensis SCHU S4 DNA/RNA endonuclease family protein YP_169631.1 629192 D 177416 CDS YP_169632.1 56707736 3191153 complement(630247..631110) 1 NC_006570.2 Similar to Q9L6I3 Extended-spectrum beta-lactamase BES-1 from Serratia marcescens (292 aa).FASTA: opt: 621 Z-score: 723.1 E(): 2.2e-32 Smith-Waterman score: 621; 34.397 identity in 282 aa overlap ORF ftt0611c; beta-lactamase 631110 3191153 FTT_0611c Francisella tularensis subsp. tularensis SCHU S4 beta-lactamase YP_169632.1 630247 R 177416 CDS YP_169633.1 56707737 3191152 631546..632358 1 NC_006570.2 ORF ftt0612; hypothetical protein 632358 3191152 FTT_0612 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169633.1 631546 D 177416 CDS YP_169634.1 56707738 3191151 complement(632679..633098) 1 NC_006570.2 This ORF is longer. ORF ftt0613c; hypothetical protein 633098 3191151 FTT_0613c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169634.1 632679 R 177416 CDS YP_169635.1 56707739 3191149 complement(633344..634834) 1 NC_006570.2 Similar to Q820B4 Apolipoprotein N-acyltransferase from Coxiella burnetii (485 aa). FASTA: opt: 984 Z-score: 1082.0 E(): 2.2e-52 Smith-Waterman score: 984; 35.903 identity in 493 aa overlap ORF ftt0614c; apolipoprotein N-acyltransferase 634834 3191149 FTT_0614c Francisella tularensis subsp. tularensis SCHU S4 apolipoprotein N-acyltransferase YP_169635.1 633344 R 177416 CDS YP_169636.1 56707740 3191148 complement(634834..635694) 1 NC_006570.2 Similar to Q8EHP0 Magnesium and cobalt efflux protein CorC from Shewanella oneidensis (291 aa). FASTA: opt: 676 Z-score: 772.4 E(): 3.9e-35 Smith-Waterman score: 676; 39.847 identity in 261 aa overlap ORF ftt0615c; metal ion transporter protein 635694 3191148 FTT_0615c Francisella tularensis subsp. tularensis SCHU S4 metal ion transporter protein YP_169636.1 634834 R 177416 CDS YP_169637.1 56707741 3191147 complement(635666..636172) 1 NC_006570.2 Similar to Q8EHN9 Hypothetical UPF0054 protein SO117 from Shewanella oneidensis (153 aa). FATSA: opt: 433 Z-score: 547.4 E(): 1.3e-22 Smith-Waterman score: 433; 44.025identity in 159 aa overlap ORF ftt0616c; hypothetical protein 636172 3191147 FTT_0616c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169637.1 635666 R 177416 CDS YP_169638.1 56707742 3191788 complement(636147..637130) 1 NC_006570.2 Simliar to Q87VY0 PhoH-like protein from Pseudomonas syringae (340 aa). FASTA: opt: 1132 Z-score: 1306.4 E(): 7.1e-65 Smith-Waterman score: 1132; 52.923 identity in 325 aa overlap; phoH-like protein 637130 phoH 3191788 phoH Francisella tularensis subsp. tularensis SCHU S4 phoH-like protein YP_169638.1 636147 R 177416 CDS YP_169639.1 56707743 3192397 complement(637149..638477) 1 NC_006570.2 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 638477 yleA 3192397 yleA Francisella tularensis subsp. tularensis SCHU S4 (dimethylallyl)adenosine tRNA methylthiotransferase YP_169639.1 637149 R 177416 CDS YP_169640.1 56707744 3191146 638700..639374 1 NC_006570.2 Similar to O67476 O-methyltransferase from Aquifex aeolicus (212 aa). FASTA: opt: 382 Z-score: 477.6 E(): 1e-18 Smith-Waterman score: 382; 33.495 identity in 206 aa overlap. ORF ftt0619; o-methyltransferase family protein 639374 3191146 FTT_0619 Francisella tularensis subsp. tularensis SCHU S4 o-methyltransferase family protein YP_169640.1 638700 D 177416 CDS YP_169641.1 56707745 3191144 639383..640126 1 NC_006570.2 Similar to Q8PER3 Acid phosphatase from Xanthomonas axonopodis (310 aa). FASTA: opt: 238 Z-score: 293.2 E(): 1.9e-08 Smith-Waterman score: 238; 24.583 identity in 240 aa overlap. ORF ftt0620; HAD superfamily protein 640126 3191144 FTT_0620 Francisella tularensis subsp. tularensis SCHU S4 HAD superfamily protein YP_169641.1 639383 D 177416 CDS YP_169642.1 56707746 3190754 640142..640735 1 NC_006570.2 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 640735 tdk 3190754 tdk Francisella tularensis subsp. tularensis SCHU S4 thymidine kinase YP_169642.1 640142 D 177416 CDS YP_169643.1 56707747 3191145 complement(640778..641242) 1 NC_006570.2 ORF ftt0622c; hypothetical protein 641242 3191145 FTT_0622c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169643.1 640778 R 177416 CDS YP_169644.1 56707748 3190785 641397..642713 1 NC_006570.2 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 642713 tig 3190785 tig Francisella tularensis subsp. tularensis SCHU S4 trigger factor YP_169644.1 641397 D 177416 CDS YP_169645.1 56707749 3192361 642739..643344 1 NC_006570.2 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 643344 clpP 3192361 clpP Francisella tularensis subsp. tularensis SCHU S4 ATP-dependent Clp protease proteolytic subunit YP_169645.1 642739 D 177416 CDS YP_169646.1 56707750 3192507 643368..644621 1 NC_006570.2 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 644621 clpX 3192507 clpX Francisella tularensis subsp. tularensis SCHU S4 ATP-dependent protease ATP-binding subunit ClpX YP_169646.1 643368 D 177416 CDS YP_169647.1 56707751 3190802 644646..646970 1 NC_006570.2 Similar to Q8Z8V0 Lon protease from Salmonella typhi (784 aa). FASTA: opt: 2734 Z-score: 2797.3 E(): 6.4e-148 Smith-Waterman score: 2734; 54.450 identity in 764 aa overlap.; DNA-binding, ATP-dependent protease La 646970 lon 3190802 lon Francisella tularensis subsp. tularensis SCHU S4 DNA-binding, ATP-dependent protease La YP_169647.1 644646 D 177416 CDS YP_169648.1 56707752 3191898 647057..647329 1 NC_006570.2 Similar to Q93TM3 Histone-like protein HU form B from Pseudomonas putida (strain KT2440) (90 aa). FASTA: opt: 380 Z-score: 519.0 E(): 5.2e-21 Smith-Waterman score: 380; 68.539 identity in 89 aa overlap.; histone-like protein HU form B 647329 hupB 3191898 hupB Francisella tularensis subsp. tularensis SCHU S4 histone-like protein HU form B YP_169648.1 647057 D 177416 CDS YP_169649.1 56707753 3191142 647441..648871 1 NC_006570.2 Similar to PPID_BUCAP (Q8K987) Peptidyl-prolyl cis-trans isomerase from Buchnera aphidicola (subsp. Schizaphis graminum) (621 aa). FASTA: opt: 298 Z-score: 309.1E(): 2.5e-09 Smith-Waterman score: 298; 23.362 identity in 351 aa overlap. 200 aa shorter (in C-term) than most of the homologs. ORF ftt0628; hypothetical protein 648871 3191142 FTT_0628 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169649.1 647441 D 177416 CDS YP_169650.1 56707754 3190845 648872..649798 1 NC_006570.2 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 649798 miaA 3190845 miaA Francisella tularensis subsp. tularensis SCHU S4 tRNA delta(2)-isopentenylpyrophosphate transferase YP_169650.1 648872 D 177416 CDS YP_169651.1 56707755 3192428 649909..650238 1 NC_006570.2 Similar to HFQ_PASMU (Q9CMC6) Hfq protein from Pasteurella multocida (95 aa). FASTA: opt: 384 Z-score: 504.4 E(): 3.3e-20 Smith-Waterman score: 384; 68.182 identity in 88 aa overlap. Plays a role in degradation of RNA transcripts.; host factor I for bacteriophage Q beta replication 650238 hfq 3192428 hfq Francisella tularensis subsp. tularensis SCHU S4 host factor I for bacteriophage Q beta replication YP_169651.1 649909 D 177416 CDS YP_169652.1 56707756 3192427 650290..651597 1 NC_006570.2 Similar to Q87VJ5 GTP-binding protein HflX from Pseudomonas syringae (pv. tomato) (433 aa). FASTA: opt: 1331 Z-score: 1520.3 E(): 8.6e-77 Smith-Waterman score: 1331; 49.302 identity in 430 aa overlap. Together with HflC-HflK involved in stability of phage lambda cII repressor; protease GTP-binding subunit 651597 hflX 3192427 hflX Francisella tularensis subsp. tularensis SCHU S4 protease GTP-binding subunit YP_169652.1 650290 D 177416 CDS YP_169653.1 56707757 3191141 complement(651608..652798) 1 NC_006570.2 Similar to O53772 oxidoreductase (Monooxygenase) from Mycobacterium tuberculosis (388 aa). FASTA: opt: 832 Z-score: 997.9 E(): 1.1e-47 Smith-Waterman score: 832; 35.550 identity in 391 aa overlap. ORF ftt0632c; hypothetical protein 652798 3191141 FTT_0632c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169653.1 651608 R 177416 CDS YP_169654.1 56707758 3192426 652970..654037 1 NC_006570.2 Similar to Q8FAK7 HflK protein from Escherichia coli (419 aa). FASTA: opt: 843 Z-score: 932.9 E(): 4.5e-44 Smith-Waterman score: 843; 40.0 identity in 330 aa overlap. With HflC, part of modulator for protease specific for FtsH phage lambda cII repressor.; hypothetical protein 654037 hflK 3192426 hflK Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169654.1 652970 D 177416 CDS YP_169655.1 56707759 3192425 654039..654965 1 NC_006570.2 Similar to Q8EJ66 HflC protein from Shewanella oneidensis (297 aa). FASTA: opt: 799 Z-score: 895.3 E(): 5.6e-42 Smith-Waterman score: 799; 42.466 identity in 292 aa overlap. With HflK, part of modulator for protease specific for FtsH phage lambda cII repressor.; hypothetical protein 654965 hflC 3192425 hflC Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169655.1 654039 D 177416 CDS YP_169656.1 56707760 3192102 654966..655451 1 NC_006570.2 Similar to O35016 YFKJ protein from Bacillus subtilis (156 aa). FASTA: opt: 391 Z-score: 494.5 E(): 1.2e-19 Smith-Waterman score: 391; 38.608 identity in 158 aa overlap.; low molecular weight (LMW) phosphotyrosine protein phosphatase 655451 wzb 3192102 wzb Francisella tularensis subsp. tularensis SCHU S4 low molecular weight (LMW) phosphotyrosine protein phosphatase YP_169656.1 654966 D 177416 CDS YP_169657.1 56707761 3191566 655448..656041 1 NC_006570.2 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 656041 engB 3191566 engB Francisella tularensis subsp. tularensis SCHU S4 ribosome biogenesis GTP-binding protein YsxC YP_169657.1 655448 D 177416 CDS YP_169658.1 56707762 3191139 657478..657828 1 NC_006570.2 fragment. Weak similarity to leuA LE12_METJA (Q58595) 2-isopropylmalate synthase 2 from Methanococcus jannaschii (518 aa). FASTA: opt: 119 Z-score: 151.8 E(): 1.5 Smith-Waterman score: 119; 26.316 identity in 114 aa overlap (6-115:356-467). Next downstream ORF also has similarity to leuA. ORF ftt0638; hypothetical protein 657828 3191139 FTT_0638 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169658.1 657478 D 177416 CDS YP_169659.1 56707763 3191138 657870..657980 1 NC_006570.2 fragment. Weak similarity to leuA LE12_METJA (Q58595) 2-isopropylmalate synthase 2 from Methanococcus jannaschii (518 aa). FASTA: opt: 86 Z-score: 142.0 E(): 5.1 Smith-Waterman score: 86; 50.000 identity in 32 aa overlap (1-32:479-510). Next upstream ORF also have similarity to leuA. ORF ftt0639; hypothetical protein 657980 3191138 FTT_0639 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169659.1 657870 D 177416 CDS YP_169660.1 56707764 3191790 658004..659659 1 NC_006570.2 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 659659 ilvD 3191790 ilvD Francisella tularensis subsp. tularensis SCHU S4 dihydroxy-acid dehydratase YP_169660.1 658004 D 177416 CDS YP_169661.1 56707765 3191561 661522..661839 1 NC_006570.2 Similar to Q8A610 Acetohydroxyacid synthase small subunit (187 aa). FASTA: opt: 159 Z-score: 221.3 E(): 0.0002 Smith-Waterman score: 159; 33.333 identity in 75 aa overlap.; acetolactate synthase small subunit 661839 ilvH 3191561 ilvH Francisella tularensis subsp. tularensis SCHU S4 acetolactate synthase small subunit YP_169661.1 661522 D 177416 CDS YP_169662.1 56707766 3192296 complement(663034..666459) 1 NC_006570.2 Similar to Q9CM06 Mfd from Pasteurella multocida (1145 aa). FASTA: opt: 3312 Z-score: 3697.7 E(): 4.5e-198 Smith-Waterman score: 3312; 44.794 identity in 1143 aa overlap.; transcription-repair coupling factor 666459 mfd 3192296 mfd Francisella tularensis subsp. tularensis SCHU S4 transcription-repair coupling factor YP_169662.1 663034 R 177416 CDS YP_169663.1 56707767 3191066 complement(666504..667190) 1 NC_006570.2 Similar to YCCA_ECOLI (P06967) Hypothetical protein yccA from Escherichia coli (219 aa). FASTA: opt: 588 Z-score: 603.2 E(): 1.1e-25 Smith-Waterman score: 588; 48.416 identity in 221 aa overlap. ORF ftt0645c; hypothetical protein 667190 3191066 FTT_0645c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169663.1 666504 R 177416 CDS YP_169664.1 56707768 3191065 complement(667306..668565) 1 NC_006570.2 ORF ftt0646c; hypothetical protein 668565 3191065 FTT_0646c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169664.1 667306 R 177416 CDS YP_169665.1 56707769 3191064 complement(668565..668996) 1 NC_006570.2 Similar to Q82WE7 Hypothetical protein from Nitrosomonas europaea (164 aa). FASTA: opt: 383 Z-score: 490.4 E(): 2e-19 Smith-Waterman score: 383; 41.606 identity in 137 aa overlap. ORF ftt0647c; hypothetical protein 668996 3191064 FTT_0647c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169665.1 668565 R 177416 CDS YP_169666.1 56707770 3191739 complement(668993..669631) 1 NC_006570.2 Similar to Q9HYB4 Endonuclease III from Pseudomonas aeruginosa (212 aa). FASTA: opt: 916 Z-score: 1153.9 E(): 2.2e-56 Smith-Waterman score: 916; 67.308identity in 208 aa overlap.; endonuclease III 669631 nth 3191739 nth Francisella tularensis subsp. tularensis SCHU S4 endonuclease III YP_169666.1 668993 R 177416 CDS YP_169667.1 56707771 3191608 complement(669624..670253) 1 NC_006570.2 Similar to Q83B23 4Fe-4S binding domain protein from Coxiella burnetii (213 aa). FASTA: opt: 552 Z-score: 680.7 E(): 5e-30 Smith-Waterman score: 552; 42.788 identity in 208 aa overlap.; (Fe-S)-binding protein 670253 rnfB 3191608 rnfB Francisella tularensis subsp. tularensis SCHU S4 (Fe-S)-binding protein YP_169667.1 669624 R 177416 CDS YP_169668.1 56707772 3192277 complement(670255..670899) 1 NC_006570.2 cofactor involved in the reduction of disulfides; glutaredoxin 670899 grxB 3192277 grxB Francisella tularensis subsp. tularensis SCHU S4 glutaredoxin YP_169668.1 670255 R 177416 CDS YP_169669.1 56707773 3191063 670961..672529 1 NC_006570.2 Similar to Q9L9P6 IraB from Legionella pneumophila (501 aa). FASTA: opt: 1486 Z-score: 1640.1 E(): 1.8e-83 Smith-Waterman score: 1486; 46.708 identity in 486 aa overlap. ORF ftt0651; proton-dependent oligopeptide transport (POT) family protein 672529 3191063 FTT_0651 Francisella tularensis subsp. tularensis SCHU S4 proton-dependent oligopeptide transport (POT) family protein YP_169669.1 670961 D 177416 CDS YP_169670.1 56707774 3191830 complement(672532..673029) 1 NC_006570.2 Similar to Q899N4 Ferritin from Clostridium tetani (169 aa). FASTA: opt: 527 Z-score: 679.5 E(): 5.9e-30 Smith-Waterman score: 527; 45.783identity in 166 aa overlap.; ferritin 673029 ftnA 3191830 ftnA Francisella tularensis subsp. tularensis SCHU S4 ferritin YP_169670.1 672532 R 177416 CDS YP_169671.1 56707775 3190780 673236..674219 1 NC_006570.2 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 674219 lipA 3190780 lipA Francisella tularensis subsp. tularensis SCHU S4 lipoyl synthase YP_169671.1 673236 D 177416 CDS YP_169672.1 56707776 3191558 674249..674908 1 NC_006570.2 Similar to Q87IN9 Sigma cross-reacting protein 27A from Vibrio parahaemolyticus (216 aa). FASTA: opt: 683 Z-score: 873.4 E(): 9.3e-41 Smith-Waterman score: 683; 49.074 identity in 216 aa overlap.; isoprenoid biosynthesis protein with amidotransferase-like domain 674908 elbB 3191558 elbB Francisella tularensis subsp. tularensis SCHU S4 isoprenoid biosynthesis protein with amidotransferase-like domain YP_169672.1 674249 D 177416 CDS YP_169673.1 56707777 3191062 674924..675670 1 NC_006570.2 Similar to YO32_SHEON (Q8EEF0) Hypothetical UPF0082 protein SO2432 from Shewanella oneidensis (248 aa). FASTA: opt: 1090 Z-score: 1308.8 E(): 5.2e-65 Smith-Waterman score: 1090; 64.516 identity in 248 aa overlap. ORF ftt0655; hypothetical protein 675670 3191062 FTT_0655 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169673.1 674924 D 177416 CDS YP_169674.1 56707778 3192532 675746..676282 1 NC_006570.2 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 676282 ruvC 3192532 ruvC Francisella tularensis subsp. tularensis SCHU S4 Holliday junction resolvase YP_169674.1 675746 D 177416 CDS YP_169675.1 56707779 3191358 677567..678220 1 NC_006570.2 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 678220 ruvA 3191358 ruvA Francisella tularensis subsp. tularensis SCHU S4 Holliday junction DNA helicase RuvA YP_169675.1 677567 D 177416 CDS YP_169676.1 56707780 3191059 678246..679658 1 NC_006570.2 Similar to Q87TH5 Conserved hypothetical protein from Vibrio parahaemolyticus (514 aa). FASTA: opt: 1129 Z-score: 1083.4 E(): 1.9e-52 Smith-Waterman score: 1132; 42.000 identity in 450 aa overlap ORF ftt0659; DNA recombination protein RmuC family protein 679658 3191059 FTT_0659 Francisella tularensis subsp. tularensis SCHU S4 DNA recombination protein RmuC family protein YP_169676.1 678246 D 177416 CDS YP_169677.1 56707781 3191060 679707..680294 1 NC_006570.2 ORF ftt0660; hypothetical protein 680294 3191060 FTT_0660 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169677.1 679707 D 177416 CDS YP_169678.1 56707782 3191057 complement(680316..680612) 1 NC_006570.2 Similar to Q82LF3 Hypothetical protein from Streptomyces avermitilis (109 aa). FASTA: opt: 260 Z-score: 364.1 E(): 2.2e-12 Smith-Waterman score: 260; 47.778 identity in 90 aa overlap. The homologs are of different sizes. ORF ftt0661c; hypothetical protein 680612 3191057 FTT_0661c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169678.1 680316 R 177416 CDS YP_169680.1 56707784 3191056 681271..682083 1 NC_006570.2 ORF ftt0663; hypothetical protein 682083 3191056 FTT_0663 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169680.1 681271 D 177416 CDS YP_169681.1 56707785 3192413 complement(682070..683206) 1 NC_006570.2 catalyzes the formation of histamine from L-histidine; histidine decarboxylase 683206 hdc 3192413 hdc Francisella tularensis subsp. tularensis SCHU S4 histidine decarboxylase YP_169681.1 682070 R 177416 CDS YP_169682.1 56707786 3191054 complement(683314..683919) 1 NC_006570.2 Similar to Q88IX8 Class II aldolase/adducin domain protein from Pseudomonas putida (strain KT2440) (251 aa). FASTA: opt: 472 Z-score: 599.3 E(): 1.7e-25 Smith-Waterman score: 472; 38.579identity in 197 aa overlap. ORF ftt0665c; aldolase 683919 3191054 FTT_0665c Francisella tularensis subsp. tularensis SCHU S4 aldolase YP_169682.1 683314 R 177416 CDS YP_169683.1 56707787 3191052 complement(684010..684591) 1 NC_006570.2 Similar to Q896H4 DNA-3-methyladenine glycosylase from Clostridium tetani (203 aa). FASTA: opt: 451 Z-score: 589.0 E(): 6.4e-25 Smith-Waterman score: 451; 42.784 identity in 194 aa overlap. ORF ftt0666c; methylpurine-DNA glycosylase family protein 684591 3191052 FTT_0666c Francisella tularensis subsp. tularensis SCHU S4 methylpurine-DNA glycosylase family protein YP_169683.1 684010 R 177416 CDS YP_169684.1 56707788 3191053 684719..685222 1 NC_006570.2 ORF ftt0667; hypothetical protein 685222 3191053 FTT_0667 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169684.1 684719 D 177416 CDS YP_169685.1 56707789 3191048 685222..685854 1 NC_006570.2 Similar to Q8A546 membrane transporter involved in nicotinamide mononucleotide transport from Bacteroides thetaiotaomicron (188 aa). FASTA: opt: 333 Z-score: 403.8 E(): 1.3e-14 Smith-Waterman score: 333; 29.016identity in 193 aa overlap. ORF ftt0668; nicotinamide mononucleotide transport (NMT) family protein 685854 3191048 FTT_0668 Francisella tularensis subsp. tularensis SCHU S4 nicotinamide mononucleotide transport (NMT) family protein YP_169685.1 685222 D 177416 CDS YP_169686.1 56707790 3191049 685952..687127 1 NC_006570.2 Similar to Q8GRF6 MagA protein from Magnetospirillum magnetotacticum (Aquaspirillum magnetotacticum) (432 aa). FASTA: opt: 769 Z-score: 826.0 E(): 4.1e-38 Smith-Waterman score: 769; 31.635identity in 373 aa overlap. ORF ftt0669; sodium/hydrogen exchanger family protein 687127 3191049 FTT_0669 Francisella tularensis subsp. tularensis SCHU S4 sodium/hydrogen exchanger family protein YP_169686.1 685952 D 177416 CDS YP_169687.1 56707791 3191047 complement(687460..687924) 1 NC_006570.2 ORF ftt0670c; hypothetical protein 687924 3191047 FTT_0670c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169687.1 687460 R 177416 CDS YP_169688.1 56707792 3191045 688237..689517 1 NC_006570.2 Similar to Q83DX6 Major facilitator family transporter from Coxiella burnetii (421 aa). FASTA: opt: 689 Z-score: 731.9 E(): 7.1e-33 Smith-Waterman score: 689; 29.197identity in 411 aa overlap. ORF ftt0671; major facilitator transporter 689517 3191045 FTT_0671 Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_169688.1 688237 D 177416 CDS YP_169689.1 56707793 3191042 complement(690789..691796) 1 NC_006570.2 Similar to Q8DF84 Predicted deacylase from Vibrio vulnificus (352 aa). FASTA: opt: 789 Z-score: 951.5 E(): 4.2e-45 Smith-Waterman score: 789; 34.328 identity in 335 aa overlap. ORF ftt0673c; hypothetical protein 691796 3191042 FTT_0673c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169689.1 690789 R 177416 CDS YP_169690.1 56707794 3191230 692007..692975 1 NC_006570.2 Similar to KPRS_RALSO (Q8Y2E1) Ribose-phosphate pyrophosphokinase from Ralstonia solanacearum (Pseudomonas solanacearum) (316 aa). FASTA: opt: 1269 Z-score: 1520.3 E(): 8.6e-77 Smith-Waterman score: 1269; 58.413 identity in 315 aa overlap.; ribose-phosphate pyrophosphokinase 692975 prsA 3191230 prsA Francisella tularensis subsp. tularensis SCHU S4 ribose-phosphate pyrophosphokinase YP_169690.1 692007 D 177416 CDS YP_169691.1 56707795 3191997 693075..693365 1 NC_006570.2 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 693365 rplY 3191997 rplY Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L25 YP_169691.1 693075 D 177416 CDS YP_169692.1 56707796 3191043 693461..694720 1 NC_006570.2 Similar to Q83E77 Hypothetical protein from Coxiella burnetii (417 aa). FASTA: opt: 1049 Z-score: 1211.5 E(): 1.4e-59 Smith-Waterman score: 1049; 40.049 identity in 407 aa overlap. ORF ftt0676; hypothetical protein 694720 3191043 FTT_0676 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169692.1 693461 D 177416 CDS YP_169693.1 56707797 3191041 complement(694925..695701) 1 NC_006570.2 Similar to Q8Z984 methyltransferase from Salmonella typhi (256 aa). FASTA: opt: 707 Z-score: 818.1 E(): 1.1e-37 Smith-Waterman score: 707; 42.570 identity in 249 aa overlap. ORF ftt0677c; hypothetical protein 695701 3191041 FTT_0677c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169693.1 694925 R 177416 CDS YP_169694.1 56707798 3191039 complement(696310..696585) 1 NC_006570.2 ORF ftt0678c; hypothetical protein 696585 3191039 FTT_0678c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169694.1 696310 R 177416 CDS YP_169695.1 56707799 3191040 complement(696600..697691) 1 NC_006570.2 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 697691 3191040 FTT_0679c Francisella tularensis subsp. tularensis SCHU S4 GTP-dependent nucleic acid-binding protein EngD YP_169695.1 696600 R 177416 CDS YP_169696.1 56707800 3191676 complement(697710..698285) 1 NC_006570.2 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 698285 pth 3191676 pth Francisella tularensis subsp. tularensis SCHU S4 peptidyl-tRNA hydrolase YP_169696.1 697710 R 177416 CDS YP_169697.1 56707801 3190964 complement(698278..699162) 1 NC_006570.2 Similar to BLAC_YEREN (Q01166) Beta-lactamase precursor from Yersinia enterocolitica (294 aa). FASTA: opt: 670 Z-score: 829.7 E(): 2.5e-38 Smith-Waterman score: 670; 36.268 identity in 284 aa overlap.; beta-lactamase class A 699162 blaA 3190964 blaA Francisella tularensis subsp. tularensis SCHU S4 beta-lactamase class A YP_169697.1 698278 R 177416 CDS YP_169698.1 56707802 3191037 complement(699171..700016) 1 NC_006570.2 ORF ftt0682c; hypothetical protein 700016 3191037 FTT_0682c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169698.1 699171 R 177416 CDS YP_169699.1 56707803 3191481 complement(700056..700874) 1 NC_006570.2 Similar to Q888U2 Type IV pilus prepilin peptidase PilD from Pseudomonas syringae (pv. tomato) (290 aa). FASTA: opt: 784 Z-score: 898.0 E(): 4e-42 Smith-Waterman score: 784; 44.531identity in 256 aa overlap. Cleaves the leader peptide of the fiber building block proteins and methylates the resulting N-terminal residue.; Type IV pili leader peptidase and methylase 700874 pilD 3191481 pilD Francisella tularensis subsp. tularensis SCHU S4 Type IV pili leader peptidase and methylase YP_169699.1 700056 R 177416 CDS YP_169700.1 56707804 3190728 complement(700878..702293) 1 NC_006570.2 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 702293 sthA 3190728 sthA Francisella tularensis subsp. tularensis SCHU S4 soluble pyridine nucleotide transhydrogenase YP_169700.1 700878 R 177416 CDS YP_169701.1 56707805 3191036 complement(702547..703530) 1 NC_006570.2 Similar to KCH_ECOLI (P31069) potassium channel protein (417 aa). FASTA: opt: 381 Z-score: 423.3 E(): 1.1e-15 Smith-Waterman score: 381; 31.203identity in 266 aa overlap. ORF ftt0685c; potassium channel protein 703530 3191036 FTT_0685c Francisella tularensis subsp. tularensis SCHU S4 potassium channel protein YP_169701.1 702547 R 177416 CDS YP_169702.1 56707806 3191033 complement(703610..704914) 1 NC_006570.2 Similar to Q83E30 Proton/peptide symporter family protein from Coxiella burnetii (492 aa). FASTA: opt: 609 Z-score: 644.8 E(): 5e-28 Smith-Waterman score: 609; 26.545 identity in 437 aa overlap. The start is approx 55 aa later than the homologs. ORF ftt0686c; proton-dependent oligopeptide transport (POT) family protein 704914 3191033 FTT_0686c Francisella tularensis subsp. tularensis SCHU S4 proton-dependent oligopeptide transport (POT) family protein YP_169702.1 703610 R 177416 CDS YP_169703.1 56707807 3192080 complement(705161..706528) 1 NC_006570.2 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 706528 hslU 3192080 hslU Francisella tularensis subsp. tularensis SCHU S4 ATP-dependent protease ATP-binding subunit HslU YP_169703.1 705161 R 177416 CDS YP_169704.1 56707808 3191560 complement(706536..707087) 1 NC_006570.2 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 707087 hslV 3191560 hslV Francisella tularensis subsp. tularensis SCHU S4 ATP-dependent protease peptidase subunit YP_169704.1 706536 R 177416 CDS YP_169705.1 56707809 3191031 707279..708028 1 NC_006570.2 ORF ftt0689; hypothetical protein 708028 3191031 FTT_0689 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169705.1 707279 D 177416 CDS YP_169706.1 56707810 3192472 complement(708031..708933) 1 NC_006570.2 Similar to Q9KS71 Lipoate-protein ligase A from Vibrio cholerae (338 aa). FASTA: opt: 699 Z-score: 831.1 E(): 2.1e-38 Smith-Waterman score: 699; 38.545identity in 275 aa overlap.; lipoate-protein ligase A 708933 lplA 3192472 lplA Francisella tularensis subsp. tularensis SCHU S4 lipoate-protein ligase A YP_169706.1 708031 R 177416 CDS YP_169707.1 56707811 3191006 709046..710236 1 NC_006570.2 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 710236 tyrS 3191006 tyrS Francisella tularensis subsp. tularensis SCHU S4 tyrosyl-tRNA synthetase YP_169707.1 709046 D 177416 CDS YP_169708.1 56707812 3190809 complement(join(710737..711195,711195..711521)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 711521 isftu1 3190809 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169708.1 710737 R 177416 CDS YP_169709.1 56707813 3192054 complement(711592..712416) 1 NC_006570.2 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 712416 mutM 3192054 mutM Francisella tularensis subsp. tularensis SCHU S4 formamidopyrimidine-DNA glycosylase YP_169709.1 711592 R 177416 CDS YP_169710.1 56707814 3191030 712510..714609 1 NC_006570.2 Similar to AAP18158 2-acyl-glycerophospho-ethanolamine acyltransferase,acyl-acyl-carrier protein synthetase from Shigella flexneri (719 aa). FASTA: opt: 735 Z-score: 862.5 E(): 3.8e-40 Smith-Waterman score: 826; 33.661identity in 508 aa overlap. n. b. No match between aa 1 and 196. Several domains missing compared to AAP18158 ORF ftt0694; hypothetical protein 714609 3191030 FTT_0694 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169710.1 712510 D 177416 CDS YP_169711.1 56707815 3191607 714615..715532 1 NC_006570.2 Similar to AAP95225 S-adenosyl-methyltransferase MraW from Haemophilus ducreyi (313 aa). FASTA: opt: 918 Z-score: 1107.1 E(): 8.9e-54 Smith-Waterman score: 918; 49.677identity in 310 aa overlap.; S-adenosyl-methyltransferase MraW 715532 mraW 3191607 mraW Francisella tularensis subsp. tularensis SCHU S4 S-adenosyl-methyltransferase MraW YP_169711.1 714615 D 177416 CDS YP_169712.1 56707816 3191028 715529..715879 1 NC_006570.2 Weak similarity to cell division protein ftsL. ORF ftt0696; hypothetical protein 715879 3191028 FTT_0696 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169712.1 715529 D 177416 CDS YP_169713.1 56707817 3191383 715872..717566 1 NC_006570.2 Similar to Q83F33 Penicillin-binding protein 3 from Coxiella burnetii (548 aa). FASTA: opt: 1361 Z-score: 1597.9 E(): 4.1e-81 Smith-Waterman score: 1361; 40.325 identity in 553 aa overlap.; peptidoglycan synthetase 717566 ftsI 3191383 ftsI Francisella tularensis subsp. tularensis SCHU S4 peptidoglycan synthetase YP_169713.1 715872 D 177416 CDS YP_169714.1 56707818 3191158 717672..717938 1 NC_006570.2 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 717938 rpsO 3191158 rpsO Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S15 YP_169714.1 717672 D 177416 CDS YP_169715.1 56707819 3191115 717995..720076 1 NC_006570.2 Similar to Q83D87 Polyribonucleotide nucleotidyltransferase from Coxiella burnetii (696 aa). FASTA: opt: 2437 Z-score: 2800.2 E(): 4.4e-148 Smith-Waterman score: 2437; 54.401identity in 693 aa overlap.; polynucleotide phosphorylase 720076 pnp 3191115 pnp Francisella tularensis subsp. tularensis SCHU S4 polynucleotide phosphorylase YP_169715.1 717995 D 177416 CDS YP_169716.1 56707820 3191027 720082..720432 1 NC_006570.2 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 720432 3191027 FTT_0700 Francisella tularensis subsp. tularensis SCHU S4 iron-sulfur cluster insertion protein ErpA YP_169716.1 720082 D 177416 CDS YP_169717.1 56707821 3192149 720442..721290 1 NC_006570.2 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 721290 kdsA 3192149 kdsA Francisella tularensis subsp. tularensis SCHU S4 2-dehydro-3-deoxyphosphooctonate aldolase YP_169717.1 720442 D 177416 CDS YP_169718.1 56707822 3192488 721301..721966 1 NC_006570.2 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 721966 udk 3192488 udk Francisella tularensis subsp. tularensis SCHU S4 uridine kinase YP_169718.1 721301 D 177416 CDS YP_169719.1 56707823 3191977 721959..722177 1 NC_006570.2 Similar to RPOZ_PSEPK (Q88C82) Probable DNA-directed RNA polymerase omega chain from Pseudomonas putida (strain KT2440) (87 aa). FASTA: opt: 194 Z-score: 293.6 E(): 1.8e-08 Smith-Waterman score: 194; 52.857 identity in 70 aa overlap.; DNA-directed RNA polymerase subunit omega 722177 rpoZ 3191977 rpoZ Francisella tularensis subsp. tularensis SCHU S4 DNA-directed RNA polymerase subunit omega YP_169719.1 721959 D 177416 CDS YP_169720.1 56707824 3191026 722442..723014 1 NC_006570.2 ORF ftt0704; hypothetical protein 723014 3191026 FTT_0704 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169720.1 722442 D 177416 CDS YP_169721.1 56707825 3191516 723103..724452 1 NC_006570.2 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 724452 rumA 3191516 rumA Francisella tularensis subsp. tularensis SCHU S4 23S rRNA 5-methyluridine methyltransferase YP_169721.1 723103 D 177416 CDS YP_169722.1 56707826 3191025 725383..726177 1 NC_006570.2 Similar to Q9CK00 Hypothetical protein PM1838 from Pasteurella multocida (234 aa). FASTA: opt: 456 Z-score: 507.2 E(): 2.3e-20 Smith-Waterman score: 456; 34.483identity in 232 aa overlap. ORF ftt0707; nicotinamide mononucleotide transport (NMT) family protein 726177 3191025 FTT_0707 Francisella tularensis subsp. tularensis SCHU S4 nicotinamide mononucleotide transport (NMT) family protein YP_169722.1 725383 D 177416 CDS YP_169723.1 56707827 3191024 726265..727518 1 NC_006570.2 Similar to Q83BD8 Major facilitator family transporter from Coxiella burnetii (411 aa). FASTA: opt: 868 Z-score: 941.6 E(): 1.5e-44 Smith-Waterman score: 868; 37.912identity in 364 aa overlap. ORF ftt0708; major facilitator transporter 727518 3191024 FTT_0708 Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_169723.1 726265 D 177416 CDS YP_169724.1 56707828 3191859 727627..728997 1 NC_006570.2 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 728997 eno 3191859 eno Francisella tularensis subsp. tularensis SCHU S4 phosphopyruvate hydratase YP_169724.1 727627 D 177416 CDS YP_169725.1 56707829 3191079 729005..729295 1 NC_006570.2 Similar to FTSB_VIBPA (Q87LQ1) Cell division protein ftsB homolog from Vibrio parahaemolyticus (93 aa). FASTA: opt: 198 Z-score: 273.8 E(): 2.3e-07 Smith-Waterman score: 198; 37.209 identity in 86 aa overlap.; cell division protein 729295 ftsB 3191079 ftsB Francisella tularensis subsp. tularensis SCHU S4 cell division protein YP_169725.1 729005 D 177416 CDS YP_169726.1 56707830 3190877 729285..729974 1 NC_006570.2 Similar to ISPD_PASMU (P57953) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (238 aa). FASTA: opt: 506 Z-score: 656.8 E(): 1.1e-28 Smith-Waterman score: 506; 39.381 identity in 226 aa overlap.; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 729974 ispD 3190877 ispD Francisella tularensis subsp. tularensis SCHU S4 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_169726.1 729285 D 177416 CDS YP_169727.1 56707831 3192377 complement(729979..731241) 1 NC_006570.2 Similar to SDAC_HAEIN (P44615) Serine transporter from Haemophilus influenzae (412 aa). FASTA: opt: 785 Z-score: 854.1 E(): 1.1e-39 Smith-Waterman score: 785; 33.099 identity in 426 aa overlap.; serine transporter 731241 sdaC1 3192377 sdaC1 Francisella tularensis subsp. tularensis SCHU S4 serine transporter YP_169727.1 729979 R 177416 CDS YP_169728.1 56707832 3190755 complement(731243..732298) 1 NC_006570.2 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 732298 tdh 3190755 tdh Francisella tularensis subsp. tularensis SCHU S4 L-threonine 3-dehydrogenase YP_169728.1 731243 R 177416 CDS YP_169729.1 56707833 3192112 complement(732321..733517) 1 NC_006570.2 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate CoA ligase 733517 kbl 3192112 kbl Francisella tularensis subsp. tularensis SCHU S4 2-amino-3-ketobutyrate CoA ligase YP_169729.1 732321 R 177416 CDS YP_169730.1 56707834 3191020 734050..736332 1 NC_006570.2 Similar to Q9ZIX2 Chitinase c from Pseudoalteromonas sp. S9 (869 aa). FASTA: opt: 331 Z-score: 370.4 E(): 9.6e-13 Smith-Waterman score: 583; 24.111 identity in 900 aa overlap. The homologs are of varying sizes. ORF ftt0715; chitinase 736332 3191020 FTT_0715 Francisella tularensis subsp. tularensis SCHU S4 chitinase YP_169730.1 734050 D 177416 CDS YP_169731.1 56707835 3191905 736511..737155 1 NC_006570.2 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 737155 upp 3191905 upp Francisella tularensis subsp. tularensis SCHU S4 uracil phosphoribosyltransferase YP_169731.1 736511 D 177416 CDS YP_169732.1 56707836 3191021 738163..738507 1 NC_006570.2 ORF ftt0718; hypothetical protein 738507 3191021 FTT_0718 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169732.1 738163 D 177416 CDS YP_169733.1 56707837 3191018 738564..739787 1 NC_006570.2 Aa 139-320 identical to AAP97846 Hypothetical protein (Fragment) from Francisella tularensis ssp. tularensis strain SchuS4 (184 aa). Similar to Q881T0 Proline/betaine transporter from Pseudomonas syringae (pv. tomato) (438 aa). FASTA: opt: 561 Z-score: 633.8 E(): 2.1e-27 Smith-Waterman score: 561; 25.616 identity in 406 aa overlap. ORF ftt0719; major facilitator transporter 739787 3191018 FTT_0719 Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_169733.1 738564 D 177416 CDS YP_169734.1 56707838 3191520 complement(739771..741096) 1 NC_006570.2 Similar to DGT1_VIBPA (Q87R73) Deoxyguanosinetriphosphate triphosphohydrolase-like protein from Vibrio parahaemolyticus (440 aa). FASTA: opt: 587 Z-score: 683.8 E(): 3.4e-30 Smith-Waterman score: 661; 33.781identity in 447 aa overlap.; deoxyguanosinetriphosphate triphosphohydrolase 741096 dgt 3191520 dgt Francisella tularensis subsp. tularensis SCHU S4 deoxyguanosinetriphosphate triphosphohydrolase YP_169734.1 739771 R 177416 CDS YP_169735.1 56707839 3192098 complement(741200..743425) 1 NC_006570.2 Similar to CATA_YERPE (Q9X6B0) Peroxidase/catalase (EC 1.11.1.6) from Yersinia pestis (737 aa). FASTA: opt: 3041 Z-score: 3508.0 E(): 1.7e-187 Smith-Waterman score: 3041; 59.189 identity in 740 aa overlap.; peroxidase/catalase 743425 katG 3192098 katG Francisella tularensis subsp. tularensis SCHU S4 peroxidase/catalase YP_169735.1 741200 R 177416 CDS YP_169736.1 56707840 3191796 complement(join(744289..744747,744747..745073)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 745073 isftu1 3191796 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169736.1 744289 R 177416 CDS YP_169737.1 56707841 3191019 complement(745380..746168) 1 NC_006570.2 Similar to Q88H18 Oxidoreductase, short chain dehydrogenase/reductase family Pseudomonas putida (strain KT2440) (248 aa). FASTA: opt: 792 Z-score: 881.9 E(): 3.1e-41 Smith-Waterman score: 792; 47.984 identity in 248 aa overlap. ORF ftt0723c; short-chain dehydrogenase 746168 3191019 FTT_0723c Francisella tularensis subsp. tularensis SCHU S4 short-chain dehydrogenase YP_169737.1 745380 R 177416 CDS YP_169738.1 56707842 3190969 complement(747571..748887) 1 NC_006570.2 Similar to Q81V41 Glycerol-3-phosphate transporter from Bacillus anthracis (strain Ames) (449 aa). FASTA: opt: 1382 Z-score: 1521.3 E(): 7.6e-77 Smith-Waterman score: 1382; 48.268identity in 433 aa overlap.; glycerol-3-phosphate transporter 748887 glpT 3190969 glpT Francisella tularensis subsp. tularensis SCHU S4 glycerol-3-phosphate transporter YP_169738.1 747571 R 177416 CDS YP_169739.1 56707843 3191017 complement(748994..750028) 1 NC_006570.2 Similar to Q89FW5 Blr6584 protein from Bradyrhizobium japonicum (342 aa). FASTA: opt: 636 Z-score: 743.1 E(): 1.7e-33 Smith-Waterman score: 743; 36.336identity in 333 aa overlap. ORF ftt0726c; glycerophosphoryl diester phosphodiesterase family protein 750028 3191017 FTT_0726c Francisella tularensis subsp. tularensis SCHU S4 glycerophosphoryl diester phosphodiesterase family protein YP_169739.1 748994 R 177416 CDS YP_169741.1 56707845 3192154 751119..752051 1 NC_006570.2 Similar to Q89II5 ABC transporter ATP-binding protein (310 aa). FASTA: opt: 1060 Z-score: 1223.8 E(): 2.8e-60 Smith-Waterman score: 1060; 54.605 identity in 304 aa overlap.; ABC transporter ATP-binding protein 752051 ybhF 3192154 ybhF Francisella tularensis subsp. tularensis SCHU S4 ABC transporter ATP-binding protein YP_169741.1 751119 D 177416 CDS YP_169742.1 56707846 3192155 752048..753166 1 NC_006570.2 Similar to Q8Y316 Probable transmembrane protein from Ralstonia solanacearum (Pseudomonas solanacearum) (381 aa). FASTA: opt: 1138 Z-score: 1260.3 E(): 2.6e-62 Smith-Waterman score: 1138; 45.722 identity in 374 aa overlap.; ABC transporter permease 753166 ybhR 3192155 ybhR Francisella tularensis subsp. tularensis SCHU S4 ABC transporter permease YP_169742.1 752048 D 177416 CDS YP_169743.1 56707847 3190910 753264..754007 1 NC_006570.2 ISFtu2. Transposase, member of the IS5 family. Identical to Q8GM03 transposase from Francisella tularensis (247 aa).; transposase 754007 isftu2 3190910 isftu2 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169743.1 753264 D 177416 CDS YP_169745.1 56707849 3192185 754790..755137 1 NC_006570.2 ORF ftt0732; hypothetical protein 755137 3192185 FTT_0732 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169745.1 754790 D 177416 CDS YP_169746.1 56707850 3192183 755166..755636 1 NC_006570.2 Similar to Q9A7J3 Glutathione peroxidase from Caulobacter crescentus (160 aa). FASTA: opt: 605 Z-score: 801.1 E(): 9.9e-37 Smith-Waterman score: 605; 55.696 identity in 158 aa overlap. ORF ftt0733; glutathione peroxidase 755636 3192183 FTT_0733 Francisella tularensis subsp. tularensis SCHU S4 glutathione peroxidase YP_169746.1 755166 D 177416 CDS YP_169747.1 56707851 3192180 757924..758571 1 NC_006570.2 Similar to Q8REM4 Hypothetical protein FN1075 (215 aa). FASTA: opt: 221 Z-score: 288.5 E(): 3.5e-08 Smith-Waterman score: 221; 25.463identity in 216 aa overlap. ORF ftt0736; hypothetical protein 758571 3192180 FTT_0736 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169747.1 757924 D 177416 CDS YP_169748.1 56707852 3192178 complement(758582..758710) 1 NC_006570.2 ORF ftt0737c; hypothetical protein 758710 3192178 FTT_0737c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169748.1 758582 R 177416 CDS YP_169749.1 56707853 3192390 758878..760422 1 NC_006570.2 Similar to Q82Y67 Possible sugar kinase from Nitrosomonas europaea (505 aa). FASTA: Z-score: 922.3 E(): 1.8e-43 Smith-Waterman score: 856; 35.529 identity in 501 aa overlap.; carbohydrate kinase family protein 760422 yjeF 3192390 yjeF Francisella tularensis subsp. tularensis SCHU S4 carbohydrate kinase family protein YP_169749.1 758878 D 177416 CDS YP_169750.1 56707854 3190937 complement(760406..760774) 1 NC_006570.2 Similar to Q88AZ6 Heat shock protein 15 from Pseudomonas syringae (pv. tomato) (135 aa). FASTA: Z-score: 549.3 E(): 1.1e-22 Smith-Waterman score: 447; 58.824 identity in 119 aa overlap.; heat shock protein 15 760774 hslR 3190937 hslR Francisella tularensis subsp. tularensis SCHU S4 heat shock protein 15 YP_169750.1 760406 R 177416 CDS YP_169753.1 56707857 3192174 763903..765891 1 NC_006570.2 ORF ftt0742; lipoprotein 765891 3192174 FTT_0742 Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_169753.1 763903 D 177416 CDS YP_169754.1 56707858 3192172 766572..767387 1 NC_006570.2 Similar to Q87Q96 Conserved hypothetical protein from Vibrio parahaemolyticus (274 aa). FASTA: opt: 950 Z-score: 1132.9 E(): 3.3e-55 Smith-Waterman score: 950; 49.259 identity in 270 aa overlap. ORF ftt0743; hypothetical protein 767387 3192172 FTT_0743 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169754.1 766572 D 177416 CDS YP_169758.1 56707862 3191854 complement(769162..769947) 1 NC_006570.2 Similar to Q88NQ3 Membrane fusion protein, (289 aa). FASTA: opt: 721 Z-score: 853.4 E(): 1.2e-39 Smith-Waterman score: 721; 41.434identity in 251 aa overlap. Similar to ydhJ and yhcQ in E. coli. ORF ftt0747c; hypothetical protein 769947 3191854 FTT_0747c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169758.1 769162 R 177416 CDS YP_169759.1 56707863 3191851 770327..771046 1 NC_006570.2 Similar to Q93PU6 regulatory protein TtgV from Pseudomonas putida (259 aa). FASTA: opt: 485 Z-score: 588.0 E(): 7.4e-25 Smith-Waterman score: 485; 33.473 identity in 239 aa overlap. ORF ftt0748; hypothetical protein 771046 3191851 FTT_0748 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169759.1 770327 D 177416 CDS YP_169760.1 56707864 3191849 complement(771106..772092) 1 NC_006570.2 Aa 8-183 identical to AAP97845 Hypothetical protein (Fragment) from Francisella tularensis ssp. tularensis strain SchuS4 (176 aa). Similar to Q8CL71 Hypothetical from Yersinia pestis (311 aa). FASTA: opt: 842 Z-score: 992.9 E(): 2e-47 Smith-Waterman score: 842; 44.710 identity in 293 aa overlap ORF ftt0749c; hypothetical protein 772092 3191849 FTT_0749c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169760.1 771106 R 177416 CDS YP_169761.1 56707865 3191848 772298..773284 1 NC_006570.2 Similar to Q83AM1 Radical SAM domain protein from Coxiella burnetii (342 aa). FASTA: opt: 1094 Z-score: 1304.2 E(): 9.4e-65 Smith-Waterman score: 1094; 48.930 identity in 327 aa overlap. ORF ftt0750; hypothetical protein 773284 3191848 FTT_0750 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169761.1 772298 D 177416 CDS YP_169762.1 56707866 3191900 complement(773355..773558) 1 NC_006570.2 Similar to Q89UH2 Cold shock protein from Bradyrhizobium japonicum (70 aa). FASTA: opt: 297 Z-score: 443.7 E(): 8e-17 Smith-Waterman score: 297; 66.176 identity in 68 aa overlap.; cold shock protein 773558 cspA 3191900 cspA Francisella tularensis subsp. tularensis SCHU S4 cold shock protein YP_169762.1 773355 R 177416 CDS YP_169764.1 56707868 3191263 774330..774530 1 NC_006570.2 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 774530 rpsU 3191263 rpsU Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S21 YP_169764.1 774330 D 177416 CDS YP_169765.1 56707869 3191844 complement(774588..774767) 1 NC_006570.2 ORF ftt0754c; hypothetical protein 774767 3191844 FTT_0754c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169765.1 774588 R 177416 CDS YP_169766.1 56707870 3191846 775183..775677 1 NC_006570.2 ORF ftt0755; hypothetical protein 775677 3191846 FTT_0755 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169766.1 775183 D 177416 CDS YP_169767.1 56707871 3191842 775768..776907 1 NC_006570.2 Similar to Q83BX5 Cation-efflux family protein from Coxiella burnetii (378 aa). FASTA: opt: 773 Z-score: 908.9 E(): 9.8e-43 Smith-Waterman score: 774; 34.605 identity in 367 aa overlap. ORF ftt0756; cation-efflux family protein 776907 3191842 FTT_0756 Francisella tularensis subsp. tularensis SCHU S4 cation-efflux family protein YP_169767.1 775768 D 177416 CDS YP_169768.1 56707872 3191600 776924..777787 1 NC_006570.2 Similar to Q9K0G7 UTP--glucose-1-phosphate uridylyltransferase from Neisseria meningitidis (serogroup B) (289 aa). FASTA: opt: 1017 Z-score: 1291.1 E(): 5e-64 Smith-Waterman score: 1017; 57.439 identity in 289 aa overlap.; UTP-glucose-1-phosphate uridylyltransferase 777787 galU 3191600 galU Francisella tularensis subsp. tularensis SCHU S4 UTP-glucose-1-phosphate uridylyltransferase YP_169768.1 776924 D 177416 CDS YP_169769.1 56707873 3191841 779260..780177 1 NC_006570.2 Similar to YYAM_BACSU (P37511) Hypothetical transport protein yyaM from Bacillus subtilis (305 aa). FASTA: opt: 402 Z-score: 452.6 E(): 2.6e-17 Smith-Waterman score: 402; 25.614 identity in 285 aa overlap. ORF ftt0759; hypothetical protein 780177 3191841 FTT_0759 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169769.1 779260 D 177416 CDS YP_169770.1 56707874 3191837 complement(780180..780386) 1 NC_006570.2 ORF ftt0760c; lipoprotein 780386 3191837 FTT_0760c Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_169770.1 780180 R 177416 CDS YP_169771.1 56707875 3191840 complement(780471..780764) 1 NC_006570.2 ORF ftt0761c; hypothetical protein 780764 3191840 FTT_0761c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169771.1 780471 R 177416 CDS YP_169772.1 56707876 3191639 complement(780786..781835) 1 NC_006570.2 Similar to RECF_PROMI (P22839) DNA replication and repair protein from Proteus mirabilis (362 aa). FASTA: opt: 874 Z-score: 1010.7 E(): 2.1e-48 Smith-Waterman score: 874; 37.394 identity in 353 aa overlap.; DNA replication and repair protein RecF 781835 recF 3191639 recF Francisella tularensis subsp. tularensis SCHU S4 DNA replication and repair protein RecF YP_169772.1 780786 R 177416 CDS YP_169773.1 56707877 3192399 complement(781839..782585) 1 NC_006570.2 Similar to YJJV_ECOLI (P39408) deoxyribonuclease yjjV (259 aa). FASTA: opt: 503 Z-score: 595.3 E(): 2.9e-25 Smith-Waterman score: 503; 31.048 identity in 248 aa overlap.; TatD related DNAse family protein 782585 yjjV 3192399 yjjV Francisella tularensis subsp. tularensis SCHU S4 TatD related DNAse family protein YP_169773.1 781839 R 177416 CDS YP_169774.1 56707878 3191775 782778..784862 1 NC_006570.2 Similar to SYGB_COXBU (P45651) Glycyl-tRNA synthetase beta chain from Coxiella burnetii (689 aa). FASTA: opt: 1810 Z-score: 2108.8 E(): 1.4e-109 Smith-Waterman score: 1810; 42.939 identity in 694 aa overlap.; glycyl-tRNA synthetase subunit beta 784862 glyS 3191775 glyS Francisella tularensis subsp. tularensis SCHU S4 glycyl-tRNA synthetase subunit beta YP_169774.1 782778 D 177416 CDS YP_169775.1 56707879 3190913 join(785002..785328,785328..785786) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 785786 isftu1 3190913 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169775.1 785002 D 177416 CDS YP_169776.1 56707880 3191517 785955..786677 1 NC_006570.2 Similar to Q9PQL0 Purine-nucleoside phosphorylase from Ureaplasma parvum (Ureaplasma urealyticum biotype 1) (239 aa). FASTA: opt: 697 Z-score: 837.2 E(): 9.7e-39 Smith-Waterman score: 697; 47.534 identity in 223 aa overlap.; purine nucleoside phosphorylase 786677 deoD 3191517 deoD Francisella tularensis subsp. tularensis SCHU S4 purine nucleoside phosphorylase YP_169776.1 785955 D 177416 CDS YP_169777.1 56707881 3191838 complement(786674..787123) 1 NC_006570.2 ORF ftt0767c; hypothetical protein 787123 3191838 FTT_0767c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169777.1 786674 R 177416 CDS YP_169778.1 56707882 3191836 complement(787127..788155) 1 NC_006570.2 ORF ftt0768c; hypothetical protein 788155 3191836 FTT_0768c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169778.1 787127 R 177416 CDS YP_169779.1 56707883 3192077 788287..791007 1 NC_006570.2 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 791007 secA 3192077 secA Francisella tularensis subsp. tularensis SCHU S4 preprotein translocase subunit SecA YP_169779.1 788287 D 177416 CDS YP_169780.1 56707884 3192001 793076..793390 1 NC_006570.2 Similar to AAP95195 50S ribosomal protein L21 from Haemophilus ducreyi (103 aa). FASTA: opt: 435 Z-score: 570.3 E(): 7.1e-24 Smith-Waterman score: 435; 66.019 identity in 103 aa overlap.; 50S ribosomal protein L21 793390 rplU 3192001 rplU Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L21 YP_169780.1 793076 D 177416 CDS YP_169781.1 56707885 3191996 793421..793675 1 NC_006570.2 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 793675 rpmA 3191996 rpmA Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L27 YP_169781.1 793421 D 177416 CDS YP_169782.1 56707886 3191834 794062..794439 1 NC_006570.2 Similar to Q8DJY4 Tll1086 protein from Synechococcus elongatus (Thermosynechococcus elongatus) (126 aa). FASTA: opt: 516 Z-score: 715.9 E(): 5.5e-32 Smith-Waterman score: 516; 64.348 identity in 115 aa overlap. ORF ftt0774; hypothetical protein 794439 3191834 FTT_0774 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169782.1 794062 D 177416 CDS YP_169783.1 56707887 3191611 complement(795675..796769) 1 NC_006570.2 Similar to Q8YGF6 Ribonuclease D from Brucella melitensis (385 aa). FASTA: opt: 538 Z-score: 584.5 E(): 1.2e-24 Smith-Waterman score: 538; 28.919 identity in 370 aa overlap.; ribonuclease D 796769 rnd 3191611 rnd Francisella tularensis subsp. tularensis SCHU S4 ribonuclease D YP_169783.1 795675 R 177416 CDS YP_169784.1 56707888 3191927 796878..798716 1 NC_006570.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 798716 uvrC 3191927 uvrC Francisella tularensis subsp. tularensis SCHU S4 excinuclease ABC subunit C YP_169784.1 796878 D 177416 CDS YP_169785.1 56707889 3192437 798783..799157 1 NC_006570.2 ORF ftt0778; hypothetical protein 799157 3192437 FTT_0778 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169785.1 798783 D 177416 CDS YP_169786.1 56707890 3190822 join(799235..799561,799561..800019) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 800019 isftu1 3190822 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169786.1 799235 D 177416 CDS YP_169787.1 56707891 3192438 complement(800295..800564) 1 NC_006570.2 ORF ftt0780c; hypothetical protein 800564 3192438 FTT_0780c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169787.1 800295 R 177416 CDS YP_169788.1 56707892 3191831 complement(800554..801267) 1 NC_006570.2 Similar to Q82UL5 Hypothetical protein from Nitrosomonas europaea (239 aa). FASTA: opt: 736 Z-score: 920.8 E(): 2.1e-43 Smith-Waterman score: 736; 54.680 identity in 203 aa overlap. The family of possible lysine decarboxylase proteins shares a highly conserved motif PGGXGTXXE that is probably functionally important. This protein has that motif. ORF ftt0781c; hypothetical protein 801267 3191831 FTT_0781c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169788.1 800554 R 177416 CDS YP_169789.1 56707893 3191864 801553..802335 1 NC_006570.2 Similar to Q87YS1 Enoyl-(acyl-carrier-protein) reductase from Pseudomonas syringae (pv. tomato) (264 aa). FASTA: opt: 1071 Z-score: 1313.1 E(): 3e-65 Smith-Waterman score: 1071; 62.595 identity in 262 aa overlap.; enoyl-ACP reductase 802335 fabI 3191864 fabI Francisella tularensis subsp. tularensis SCHU S4 enoyl-ACP reductase YP_169789.1 801553 D 177416 CDS YP_169790.1 56707894 3190951 802482..803444 1 NC_006570.2 Similar to Q9CPJ8 Arylsulfatase from Pasteurella multocida (327 aa). FASTA: opt: 544 Z-score: 669.4 E(): 2.2e-29 Smith-Waterman score: 544; 31.420 identity in 331 aa overlap.; arylsulfatase 803444 ars 3190951 ars Francisella tularensis subsp. tularensis SCHU S4 arylsulfatase YP_169790.1 802482 D 177416 CDS YP_169791.1 56707895 3191824 803456..803785 1 NC_006570.2 ORF ftt0784; hypothetical protein 803785 3191824 FTT_0784 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169791.1 803456 D 177416 CDS YP_169792.1 56707896 3191822 803773..804594 1 NC_006570.2 Similar to Q88K93 Conserved hypothetical protein (277 aa). FASTA: opt: 718 Z-score: 855.8 E(): 8.9e-40 Smith-Waterman score: 718; 42.308identity in 260 aa overlap. ORF ftt0785; hypothetical protein 804594 3191822 FTT_0785 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169792.1 803773 D 177416 CDS YP_169793.1 56707897 3191821 804591..805289 1 NC_006570.2 ORF ftt0786; hypothetical protein 805289 3191821 FTT_0786 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169793.1 804591 D 177416 CDS YP_169794.1 56707898 3191820 805300..805890 1 NC_006570.2 Similar to Q8EDN3 Conserved hypothetical protein from Shewanella oneidensis (197 aa). FASTA: opt: 435 Z-score: 540.9 E(): 3.1e-22 Smith-Waterman score: 435; 42.935 identity in 184 aa overlap. ORF ftt0787; DoxD-like family protein 805890 3191820 FTT_0787 Francisella tularensis subsp. tularensis SCHU S4 DoxD-like family protein YP_169794.1 805300 D 177416 CDS YP_169795.1 56707899 3192129 complement(805894..806877) 1 NC_006570.2 Similar to Q8KLW6 Hypothetical protein from Pseudomonas stutzeri (Pseudomonas perfectomarina) (324 aa). FASTA: opt: 1095 Z-score: 1307.1 E(): 6.5e-65 Smith-Waterman score: 1095; 54.489 identity in 323 aa overlap. Homologs are involved in sialic acid capsule biosynthesis in some pathogenic strains of Escherichia coli.; arabinose phosphate isomerase 806877 kdsD 3192129 kdsD Francisella tularensis subsp. tularensis SCHU S4 arabinose phosphate isomerase YP_169795.1 805894 R 177416 CDS YP_169796.1 56707900 3192026 807002..807670 1 NC_006570.2 Similar to Q8EK14 Ribulose-phosphate 3-epimerase (225 aa). FASTA: opt: 953 Z-score: 1164.4 E(): 5.8e-57 Smith-Waterman score: 953; 65.766identity in 222 aa overlap.; D-ribulose-phosphate 3-epimerase 807670 rpe 3192026 rpe Francisella tularensis subsp. tularensis SCHU S4 D-ribulose-phosphate 3-epimerase YP_169796.1 807002 D 177416 CDS YP_169797.1 56707901 3191819 807651..809045 1 NC_006570.2 Similar to Q9FDJ5 glycosyltransferase from Lactobacillus rhamnosus (466 aa). FASTA: opt: 733 Z-score: 876.0 E(): 6.7e-41 Smith-Waterman score: 733; 33.333 identity in 399 aa overlap. ORF ftt0790; sugar transferase 809045 3191819 FTT_0790 Francisella tularensis subsp. tularensis SCHU S4 sugar transferase YP_169797.1 807651 D 177416 CDS YP_169798.1 56707902 3191584 809038..810057 1 NC_006570.2 UDP-glucose 4-epimerase 810057 galE 3191584 galE Francisella tularensis subsp. tularensis SCHU S4 UDP-glucose 4-epimerase YP_169798.1 809038 D 177416 CDS YP_169799.1 56707903 3191845 810061..811290 1 NC_006570.2 Similar to Q9HTC0 Glycosyltransferase WbpZ from Pseudomonas aeruginosa (381 aa). FASTA: opt: 621 Z-score: 721.7 E(): 2.6e-32 Smith-Waterman score: 1019; 38.725 identity in 408 aa overlap. ORF ftt0792; glycosyl transferase family protein 811290 3191845 FTT_0792 Francisella tularensis subsp. tularensis SCHU S4 glycosyl transferase family protein YP_169799.1 810061 D 177416 CDS YP_169800.1 56707904 3191818 811287..812969 1 NC_006570.2 Similar to Q8DMA7 ATP-binding protein of ABC transporter from Synechococcus elongatus (Thermosynechococcus elongatus) (610 aa). FASTA: opt: 1084 Z-score: 1105.1 E(): 1.2e-53 Smith-Waterman score: 1084; 35.159 identity in 566 aa overlap. ORF ftt0793; ABC transporter ATP-binding protein/permease 812969 3191818 FTT_0793 Francisella tularensis subsp. tularensis SCHU S4 ABC transporter ATP-binding protein/permease YP_169800.1 811287 D 177416 CDS YP_169801.1 56707905 3191816 812983..814269 1 NC_006570.2 Similar to AAP76675 Phosphoserine phosphatase from Helicobacter hepaticus (199 aa). FASTA: opt: 751 Z-score: 908.2 E(): 1.1e-42 Smith-Waterman score: 751; 55.385 identity in 195 aa overlap (18-212:4-198) AND to AAP76674 Hypothetical protein from Helicobacter hepaticus (213 aa). FASTA: opt: 823 Z-score: 994.3 E(): 1.7e-47 Smith-Waterman score: 823; 57.212 identity in 208 aa overlap (221-428:6-213). Seems to be two genes in some organisms. ORF ftt0794; hypothetical protein 814269 3191816 FTT_0794 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169801.1 812983 D 177416 CDS YP_169802.1 56707906 3191817 814208..814891 1 NC_006570.2 Similar to AAP76671 Hypothetical protein cfa from Helicobacter hepaticus (210 aa). FASTA: opt: 627 Z-score: 745.4 E(): 1.3e-33 Smith-Waterman score: 627; 44.660 identity in 206 aa overlap. ORF ftt0795; hypothetical protein 814891 3191817 FTT_0795 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169802.1 814208 D 177416 CDS YP_169803.1 56707907 3191828 814895..815656 1 NC_006570.2 ORF ftt0796; hypothetical protein 815656 3191828 FTT_0796 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169803.1 814895 D 177416 CDS YP_169804.1 56707908 3191827 815665..816624 1 NC_006570.2 Similar to O85000 Galactosyl transferase from Streptococcus pneumoniae (323 aa). FASTA: opt: 577 Z-score: 682.7 E(): 3.9e-30 Smith-Waterman score: 577; 40.171 identity in 234 aa overlap. Same homolog as for next downstream ORF. ORF ftt0797; glycosyl transferase family protein 816624 3191827 FTT_0797 Francisella tularensis subsp. tularensis SCHU S4 glycosyl transferase family protein YP_169804.1 815665 D 177416 CDS YP_169805.1 56707909 3191812 816641..817648 1 NC_006570.2 Similar to O85000 Galactosyl transferase from Streptococcus pneumoniae (323 aa). FASTA: opt: 499 Z-score: 609.1 E(): 4.9e-26 Smith-Waterman score: 499; 34.454 identity in 238 aa overlap. Same homolog as for next upstream ORF. ORF ftt0798; glycosyl transferase family protein 817648 3191812 FTT_0798 Francisella tularensis subsp. tularensis SCHU S4 glycosyl transferase family protein YP_169805.1 816641 D 177416 CDS YP_169806.1 56707910 3191811 817651..818664 1 NC_006570.2 Similar to Q00481 Second mannosyl transferase from Salmonella enterica (336 aa). FASTA: opt: 651 Z-score: 775.2 E(): 2.7e-35 Smith-Waterman score: 651; 35.455 identity in 330 aa overlap. ORF ftt0799; glycosyl transferases group 1 family protein 818664 3191811 FTT_0799 Francisella tularensis subsp. tularensis SCHU S4 glycosyl transferases group 1 family protein YP_169806.1 817651 D 177416 CDS YP_169807.1 56707911 3191810 818683..819345 1 NC_006570.2 Similar to Q8FV27 Hydrolase, haloacid dehalogenase-like family from Brucella suis (234 aa). FASTA: opt: 422 Z-score: 503.3 E(): 3.8e-20 Smith-Waterman score: 422; 33.486identity in 218 aa overlap. ORF ftt0800; haloacid dehalogenase 819345 3191810 FTT_0800 Francisella tularensis subsp. tularensis SCHU S4 haloacid dehalogenase YP_169807.1 818683 D 177416 CDS YP_169808.1 56707912 3191809 complement(819627..820733) 1 NC_006570.2 Similar to Q9YG89 310AA long hypothetical sugar kinase from Aeropyrum pernix (310 aa). FASTA: opt: 245 Z-score: 292.6 E(): 2.1e-08 Smith-Waterman score: 311; 25.795 identity in 283 aa overlap. ORF ftt0801c; carbohydrate/purine kinase pfkB family protein 820733 3191809 FTT_0801c Francisella tularensis subsp. tularensis SCHU S4 carbohydrate/purine kinase pfkB family protein YP_169808.1 819627 R 177416 CDS YP_169809.1 56707913 3191887 820936..821754 1 NC_006570.2 Similar to CPHB_SYNY8 (P56946) Cyanophycinase from Synechocystis sp. (strain PCC 6308) (272 aa). FASTA: opt: 701 Z-score: 857.3 E(): 7.4e-40 Smith-Waterman score: 701; 41.667 identity in 264 aa overlap.; cyanophycinase 821754 cphB 3191887 cphB Francisella tularensis subsp. tularensis SCHU S4 cyanophycinase YP_169809.1 820936 D 177416 CDS YP_169810.1 56707914 3190806 821970..822833 1 NC_006570.2 Similar to Q9ABX3 Asparaginase family protein from Caulobacter crescentus (292 aa). FASTA: 146 opt: 465 Z-score: 567.7 E(): 1e-23 Smith-Waterman score: 465; 35.606 identity in 264 aa overlap.; asparaginase 822833 ans 3190806 ans Francisella tularensis subsp. tularensis SCHU S4 asparaginase YP_169810.1 821970 D 177416 CDS YP_169811.1 56707915 3191808 823505..824761 1 NC_006570.2 Similar to O54543 (O54543) CITA from Legionella pneumophila (418 aa). FASTA: opt: 905 Z-score: 915.1 E(): 4.5e-43 Smith-Waterman score: 905; 33.254 identity in 418 aa overlap. ORF ftt0804; major facilitator transporter 824761 3191808 FTT_0804 Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_169811.1 823505 D 177416 CDS YP_169812.1 56707916 3190971 824837..826054 1 NC_006570.2 Similar to CAD71904 Capsule biosynthesis protein CapB from Rhodopirellula baltica (441 aa). FASTA: opt: 1155 Z-score: 1414.5 E(): 6.8e-71 Smith-Waterman score: 1156; 46.763 identity (50.914 ungapped) in 417 aa overlap.; capsule biosynthesis protein CapB 826054 capB 3190971 capB Francisella tularensis subsp. tularensis SCHU S4 capsule biosynthesis protein CapB YP_169812.1 824837 D 177416 CDS YP_169813.1 56707917 3192366 826079..826543 1 NC_006570.2 Similar to Q8REZ4 CapC protein from Fusobacterium nucleatum (152 aa). FASTA: opt: 360 Z-score: 420.9 E(): 1.5e-15 Smith-Waterman score: 360; 35.616 identity in 146 aa overlap.; capsule biosynthesis protein CapC 826543 capC 3192366 capC Francisella tularensis subsp. tularensis SCHU S4 capsule biosynthesis protein CapC YP_169813.1 826079 D 177416 CDS YP_169814.2 255961457 3191829 826545..827756 1 NC_006570.2 Similar to CAD71902 Hypothetical protein from Rhodopirellula baltica (404 aa). FASTA: opt: 477 Z-score: 563.9 E(): 1.6e-23 Smith-Waterman score: 553; 31.633 identity in 392 aa overlap. ORF ftt0807; hypothetical protein 827756 3191829 FTT_0807 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169814.2 826545 D 177416 CDS YP_169815.1 56707919 3190723 827816..829939 1 NC_006570.2 Similar to SPOT_ECOLI Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase from Escherichia coli (702 aa). FASTA: opt: 1849 Z-score: 2107.7 E(): 1.7e-109 Smith-Waterman score: 1849; 41.210 identity in 711 aa overlap.; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 829939 spoT 3190723 spoT Francisella tularensis subsp. tularensis SCHU S4 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase YP_169815.1 827816 D 177416 CDS YP_169816.1 56707920 3191634 complement(829947..830549) 1 NC_006570.2 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 830549 recR 3191634 recR Francisella tularensis subsp. tularensis SCHU S4 recombination protein RecR YP_169816.1 829947 R 177416 CDS YP_169817.1 56707921 3192128 complement(830549..830887) 1 NC_006570.2 Similar to YBAB_ECOLI Hypothetical UPF0133 protein ybaB from Escherichia coli (109 aa). FASTA: opt: 332 Z-score: 403.8 E(): 1.3e-14 Smith-Waterman score: 332; 49.074identity in 108 aa overlap.; hypothetical protein 830887 ybaB 3192128 ybaB Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169817.1 830549 R 177416 CDS YP_169818.1 56707922 3192028 complement(830897..832012) 1 NC_006570.2 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 832012 murG 3192028 murG Francisella tularensis subsp. tularensis SCHU S4 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_169818.1 830897 R 177416 CDS YP_169819.1 56707923 3191479 832116..832496 1 NC_006570.2 Similar to GCS1_SULTO Probable glycine cleavage system H from Sulfolobus tokodaii (142 aa). FASTA: opt: 397 Z-score: 525.8 E(): 2.1e-21 Smith-Waterman score: 397; 43.089 identity in 123 aa overlap.; glycine cleavage system protein H 832496 gcvH2 3191479 gcvH2 Francisella tularensis subsp. tularensis SCHU S4 glycine cleavage system protein H YP_169819.1 832116 D 177416 CDS YP_169820.1 56707924 3190926 832486..832782 1 NC_006570.2 ORF ftt0813; hypothetical protein 832782 3190926 FTT_0813 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169820.1 832486 D 177416 CDS YP_169824.1 56707928 3190763 835100..837004 1 NC_006570.2 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 837004 thrS 3190763 thrS Francisella tularensis subsp. tularensis SCHU S4 threonyl-tRNA synthetase YP_169824.1 835100 D 177416 CDS YP_169825.1 56707929 3191791 837080..837547 1 NC_006570.2 Similar to IF3_ECOLI Translation initiation factor IF-3 from Escherichia coli (180 aa). FASTA: opt: 674 Z-score: 836.1 E(): 1.1e-38 Smith-Waterman score: 674; 64.103 identity in 156 aa overlap.; translation initiation factor IF-3 837547 infC 3191791 infC Francisella tularensis subsp. tularensis SCHU S4 translation initiation factor IF-3 YP_169825.1 837080 D 177416 CDS YP_169826.1 56707930 3191986 837590..837787 1 NC_006570.2 Similar to RL35_ECOLI 50S ribosomal protein L35 from Escherichia coli (64 aa). FASTA: opt: 247 Z-score: 385.9 E(): 1.3e-13 Smith-Waterman score: 247; 62.500 identity in 64 aa overlap.; 50S ribosomal protein L35 837787 rpmI 3191986 rpmI Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L35 YP_169826.1 837590 D 177416 CDS YP_169827.1 56707931 3192002 837823..838179 1 NC_006570.2 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 838179 rplT 3192002 rplT Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L20 YP_169827.1 837823 D 177416 CDS YP_169828.1 56707932 3192335 838221..838925 1 NC_006570.2 Similar to Q9KRB9 Hypothetical protein VC1723 from Vibrio cholerae (229 aa). FASTA: opt: 344 Z-score: 394.7 E(): 4.3e-14 Smith-Waterman score: 344; 29.075 identity in 227 aa overlap. ORF ftt0821; hypothetical protein 838925 3192335 FTT_0821 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169828.1 838221 D 177416 CDS YP_169829.1 56707933 3191797 join(839217..839543,839543..840001) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 840001 isftu1 3191797 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169829.1 839217 D 177416 CDS YP_169830.1 56707934 3191835 840225..840872 1 NC_006570.2 Similar to Q9K8B7 Mutator MutT protein from Bacillus halodurans (207 aa). FASTA: opt: 413 Z-score: 505.4 E(): 2.9e-20 Smith-Waterman score: 413; 36.649identity in 191 aa overlap. ORF ftt0823; MutT protein 840872 3191835 FTT_0823 Francisella tularensis subsp. tularensis SCHU S4 MutT protein YP_169830.1 840225 D 177416 CDS YP_169831.1 56707935 3192546 840890..841243 1 NC_006570.2 Similar to Q8CPW9 Arsenate reductase from Staphylococcus epidermidis (117 aa). FASTA: opt: 276 Z-score: 376.2 E(): 4.6e-13 Smith-Waterman score: 276; 32.759 identity in 116 aa overlap.; arsenate reductase 841243 arsC1 3192546 arsC1 Francisella tularensis subsp. tularensis SCHU S4 arsenate reductase YP_169831.1 840890 D 177416 CDS YP_169832.1 56707936 3191761 complement(841267..841602) 1 NC_006570.2 hypothetical lipoprotein, no significant homologs. ORF ftt0825c; hypothetical protein 841602 3191761 FTT_0825c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169832.1 841267 R 177416 CDS YP_169833.1 56707937 3191760 complement(841779..842024) 1 NC_006570.2 ORF ftt0826c; lipoprotein 842024 3191760 FTT_0826c Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_169833.1 841779 R 177416 CDS YP_169834.1 56707938 3191758 complement(842102..843415) 1 NC_006570.2 Similar to YIEG_ECOLI Hypothetical protein yieG from Escherichia coli (445 aa). FASTA: opt: 945 Z-score: 1037.7 E(): 6.6e-50 Smith-Waterman score: 945; 34.633 identity in 436 aa overlap. ORF ftt0827c; hypothetical protein 843415 3191758 FTT_0827c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169834.1 842102 R 177416 CDS YP_169835.1 56707939 3191754 complement(845080..846795) 1 NC_006570.2 Similar to Q845W9 Aspartate:alanine antiporter from Pseudomonas dacunhae (561 aa). FASTA: opt: 1359 Z-score: 1502.2 bits: 287.8 E(): 8.8e-76 Smith-Waterman score: 1359; 38.351 identity in 558 aa overlap. ORF ftt0829c; aspartate:alanine antiporter 846795 3191754 FTT_0829c Francisella tularensis subsp. tularensis SCHU S4 aspartate:alanine antiporter YP_169835.1 845080 R 177416 CDS YP_169836.1 56707940 3191752 complement(847950..849203) 1 NC_006570.2 Weakly similar to Q8A8H3 Outer membrane protein,OmpA family from Bacteroides thetaiotaomicron (266 aa). FASTA: opt: 184 Z-score: 220.7 E(): 0.00021 Smith-Waterman score: 184; 29.299 identity in 157 aa overlap. ORF ftt0831c; OmpA family protein 849203 3191752 FTT_0831c Francisella tularensis subsp. tularensis SCHU S4 OmpA family protein YP_169836.1 847950 R 177416 CDS YP_169837.1 56707941 3191946 849395..849859 1 NC_006570.2 Similar to FKBX_ECOLI (P22563) FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase from Escherichia coli (148 aa). FASTA: opt: 357 Z-score: 475.0 E(): 1.4e-18 Smith-Waterman score: 357; 38.129 identity in 139 aa overlap.; FKBP-type peptidylprolyl isomerase 849859 fkpB 3191946 fkpB Francisella tularensis subsp. tularensis SCHU S4 FKBP-type peptidylprolyl isomerase YP_169837.1 849395 D 177416 CDS YP_169838.1 56707942 3190808 849840..850796 1 NC_006570.2 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 850796 ispH 3190808 ispH Francisella tularensis subsp. tularensis SCHU S4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_169838.1 849840 D 177416 CDS YP_169839.1 56707943 3190933 850798..851160 1 NC_006570.2 Similar to CHMU_BACSU Chorismate mutase from Bacillus subtilis (127 aa). FASTA: opt: 360 Z-score: 492.8 E(): 1.5e-19 Smith-Waterman score: 360; 48.305identity in 118 aa overlap.; chorismate mutase 851160 aroQ 3190933 aroQ Francisella tularensis subsp. tularensis SCHU S4 chorismate mutase YP_169839.1 850798 D 177416 CDS YP_169840.1 56707944 3191751 851169..851990 1 NC_006570.2 Similar to Q8EBE8 CDP-diacylglycerol--serine O-phosphatidyltransferase from Shewanella oneidensis (269 aa). FASTA: opt: 456 Z-score: 550.1 E(): 9.5e-23 Smith-Waterman score: 564; 37.209 identity in 258 aa overlap. ORF ftt0835; CDP-alcohol phosphatidyltransferase 851990 3191751 FTT_0835 Francisella tularensis subsp. tularensis SCHU S4 CDP-alcohol phosphatidyltransferase YP_169840.1 851169 D 177416 CDS YP_169841.1 56707945 3191749 complement(851995..852219) 1 NC_006570.2 ORF ftt0836c; hypothetical protein 852219 3191749 FTT_0836c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169841.1 851995 R 177416 CDS YP_169842.1 56707946 3191457 852360..853079 1 NC_006570.2 Similar to TOLQ_ECOLI TolQ protein from Escherichia coli (230 aa). FASTA: opt: 568 Z-score: 690.3 E(): 1.5e-30 Smith-Waterman score: 568; 38.991 identity in 218 aa overlap.; TolQ protein 853079 tolQ 3191457 tolQ Francisella tularensis subsp. tularensis SCHU S4 TolQ protein YP_169842.1 852360 D 177416 CDS YP_169843.1 56707947 3191469 853089..853535 1 NC_006570.2 Similar to TOLR_ECOLI TolR protein from Escherichia coli (142 aa). FASTA: opt: 303 Z-score: 379.2 bits: 76.1 E(): 3.2e-13 Smith-Waterman score: 303; 39.259identity in 135 aa overlap.; TolR protein 853535 tolR 3191469 tolR Francisella tularensis subsp. tularensis SCHU S4 TolR protein YP_169843.1 853089 D 177416 CDS YP_169844.1 56707948 3191750 853522..854433 1 NC_006570.2 FTT0839 Contains similarity to Pfam domain PF06519 (TolA protein), Score=-66.2, E-value=1.4e-05; hypothetical protein 854433 tolA 3191750 tolA Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169844.1 853522 D 177416 CDS YP_169845.1 56707949 3190788 854433..855752 1 NC_006570.2 Similar to TOLB_ECOLI TolB protein precursor from Eschericia coli (430 aa). FASTA: opt: 692 Z-score: 785.2 E(): 7.6e-36 Smith-Waterman score: 717; 31.685identity in 445 aa overlap. TolB appears more highly conserved in other species: potential paralog; TolB protein precursor 855752 tolB 3190788 tolB Francisella tularensis subsp. tularensis SCHU S4 TolB protein precursor YP_169845.1 854433 D 177416 CDS YP_169846.1 56707950 3191747 855756..856007 1 NC_006570.2 ORF ftt0841; lipoprotein 856007 3191747 FTT_0841 Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_169846.1 855756 D 177416 CDS YP_169847.1 56707951 3191746 856026..856649 1 NC_006570.2 Similar to PAL_ECOLI Peptidoglycan-associated lipoprotein from Escherichia coli (173 aa). FASTA: opt: 306 Z-score: 383.2 E(): 1.9e-13 Smith-Waterman score: 306; 33.333 identity in 162 aa overlap. ORF ftt0842; peptidoglycan-associated lipoprotein 856649 3191746 FTT_0842 Francisella tularensis subsp. tularensis SCHU S4 peptidoglycan-associated lipoprotein YP_169847.1 856026 D 177416 CDS YP_169848.1 56707952 3191743 858877..859152 1 NC_006570.2 Similar to Q9K315 Hypothetical protein VCA0343 OR VCA029 from Vibrio cholerae (83 aa). FASTA: opt: 250 Z-score: 356.2 E(): 6e-12 Smith-Waterman score: 250; 58.462 identity (58.4620ngapped) in 65 aa overlap. ORF ftt0845; hypothetical protein 859152 3191743 FTT_0845 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169848.1 858877 D 177416 CDS YP_169849.1 56707953 3191742 859133..860632 1 NC_006570.2 Similar to Q9KS67 Deoxyribodipyrimidine photolyase, from Vibrio cholerae (504 aa). FASTA: opt: 1071 Z-score: 1263.0 E(): 1.8e-62 Smith-Waterman score: 1097; 37.817 identity in 513 aa overlap. ORF ftt0846; deoxyribodipyrimidine photolyase 860632 3191742 FTT_0846 Francisella tularensis subsp. tularensis SCHU S4 deoxyribodipyrimidine photolyase YP_169849.1 859133 D 177416 CDS YP_169850.1 56707954 3191738 860686..862161 1 NC_006570.2 Similar to Q8U6P2 Hypothetical protein Atu4765 (507 aa). FASTA: opt: 1800 Z-score: 2192.9 415.3 E(): 3e-114 Smith-Waterman score: 1800; 53.608identity in 485 aa overlap. ORF ftt0847; hypothetical protein 862161 3191738 FTT_0847 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169850.1 860686 D 177416 CDS YP_169851.1 56707955 3191736 862158..862295 1 NC_006570.2 Similar to Q8P3G1 Hypothetical protein XCC4110 from Xanthomonas campestris (51 aa). FASTA: opt: 243 Z-score: 366.5 E(): 1.6e-12 Smith-Waterman score: 243; 63.636 identity in 44 aa overlap ORF ftt0848; hypothetical protein 862295 3191736 FTT_0848 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169851.1 862158 D 177416 CDS YP_169852.1 56707956 3191737 862421..863350 1 NC_006570.2 Similar to Q81YH5 Bile acid transporter family protein from Bacillus anthracis (322 aa). FASTA: initn: 551 init1: 399 opt: 605 Z-score: 641.1 E(): 8.1e-28 Smith-Waterman score: 605; 32.432identity in 296 aa overlap. ORF ftt0849; bile acid symporter family protein 863350 3191737 FTT_0849 Francisella tularensis subsp. tularensis SCHU S4 bile acid symporter family protein YP_169852.1 862421 D 177416 CDS YP_169853.1 56707957 3191735 863400..864023 1 NC_006570.2 Similar to Q930D7 Hypothetical protein RA0261 Rhizobium meliloti (222 aa). FASTA: opt: 521 Z-score: 614.9 E(): 2.3e-26 Smith-Waterman score: 521; 42.424 identity in 198 aa overlap. ORF ftt0850; hypothetical protein 864023 3191735 FTT_0850 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169853.1 863400 D 177416 CDS YP_169854.1 56707958 3191740 864047..864805 1 NC_006570.2 Similar to Q83C04 Membrane protein, from Coxiella burnetii (263 aa). FASTA: opt: 338 Z-score: 387.6 E(): 1.1e-13 Smith-Waterman score: 341; 28.625 identity in 269 aa overlap. ORF ftt0851; hypothetical protein 864805 3191740 FTT_0851 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169854.1 864047 D 177416 CDS YP_169855.1 56707959 3191733 866499..867737 1 NC_006570.2 Similar to Q8PY17 Arsenite permease from Methanosarcina mazei (420 aa). FASTA: opt: 1294 Z-score: 1359.3 E(): 8e-68 Smith-Waterman score: 1294; 49.144 identity in 409 aa overlap. ORF ftt0853; arsenite permease family protein 867737 3191733 FTT_0853 Francisella tularensis subsp. tularensis SCHU S4 arsenite permease family protein YP_169855.1 866499 D 177416 CDS YP_169856.1 56707960 3191732 complement(867716..868138) 1 NC_006570.2 Similar to Q8EM34 Hypothetical conserved protein from Oceanobacillus iheyensis (123 aa). FASTA: opt: 271 Z-score: 341.6 E(): 3.9e-11 Smith-Waterman score: 271; 37.190 identity in 121 aa overlap. ORF ftt0854c; hypothetical protein 868138 3191732 FTT_0854c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169856.1 867716 R 177416 CDS YP_169857.1 56707961 3191731 complement(868158..868517) 1 NC_006570.2 Weakly similar to Q9KR35 Hypothetical protein VC1812 from Vibrio cholerae (139 aa). FASTA: opt: 184 Z-score: 256.0 E(): 2.3e-06 Smith-Waterman score: 184; 29.245 identity in 106 aa overlap. ORF ftt0855c; hypothetical protein 868517 3191731 FTT_0855c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169857.1 868158 R 177416 CDS YP_169858.1 56707962 3192470 complement(868531..869385) 1 NC_006570.2 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; 4-hydroxybenzoate polyprenyltransferase 869385 ubiA 3192470 ubiA Francisella tularensis subsp. tularensis SCHU S4 4-hydroxybenzoate polyprenyltransferase YP_169858.1 868531 R 177416 CDS YP_169859.1 56707963 3191729 complement(869388..869894) 1 NC_006570.2 Weakly similar to similar to Q83F94 Chorismate--pyruvate lyase, from Coxiella burnetii (185 aa). FASTA: opt: 178 Z-score: 231.0 E(): 5.6e-05 Smith-Waterman score: 178; 27.215identity in 158 aa overlap ORF ftt0857c; hypothetical protein 869894 3191729 FTT_0857c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169859.1 869388 R 177416 CDS YP_169860.1 56707964 3192025 869993..870700 1 NC_006570.2 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 870700 rph 3192025 rph Francisella tularensis subsp. tularensis SCHU S4 ribonuclease PH YP_169860.1 869993 D 177416 CDS YP_169861.1 56707965 3191728 complement(870754..871077) 1 NC_006570.2 ORF ftt0859c; hypothetical protein 871077 3191728 FTT_0859c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169861.1 870754 R 177416 CDS YP_169862.1 56707966 3191726 complement(871182..871433) 1 NC_006570.2 ORF ftt0860c; hypothetical protein 871433 3191726 FTT_0860c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169862.1 871182 R 177416 CDS YP_169863.1 56707967 3191727 complement(871496..872089) 1 NC_006570.2 Similar to FMA2_BACNO (P17824) Fimbrial protein precursor (Pilin) from Bacteroides nodosus (Dichelobacter nodosus) (160 aa). FASTA: opt: 169 Z-score: 222.1 E(): 0.00018 Smith-Waterman score: 169; 34.646 identity in 127 aa overlap The pili fiber building block protein has a highly distinct primary structure; a short positively charged leader sequence, and a highly conserved and highly hydrophobic amino-terminal domain which forms the core of the pilus fiber; A variety of studies suggest that the invariant glycine (G) at -1 is required for prepilin cleavage and assembly and that the glutamate (E) at + 5 is essential for assembly and efficient N-terminal methylation but not cleavage. The region near the carboxy terminus is often hydrophilic and is stabilized by one or two disulfide bridges that may be involved in recognition of receptors. The genes with these characteristics are usually termed pilA, pilE, pilV, pilW, pilX and FimU. (Mattick John S.. 'Type IV Pili and twitching motility'. Annu. Rev. Microbiol. 2002. 56:289-314.) This protein has all the characteristics described above, but shows a weak global homology. ORF ftt0861c; Type IV pili fiber building block protein 872089 3191727 FTT_0861c Francisella tularensis subsp. tularensis SCHU S4 Type IV pili fiber building block protein YP_169863.1 871496 R 177416 CDS YP_169864.1 56707968 3191549 complement(872194..873267) 1 NC_006570.2 metalloprotease; heat shock protein HtpX 873267 htpX 3191549 htpX Francisella tularensis subsp. tularensis SCHU S4 heat shock protein HtpX YP_169864.1 872194 R 177416 CDS YP_169865.1 56707969 3191725 complement(873271..873846) 1 NC_006570.2 Similar to Q83DZ3 LemA protein from Coxiella burnetii (192 aa) initn: 723 init1: 655 opt: 732 Z-score: 803.2 bits: 155.4 E(): 7.6e-37 Smith-Waterman score: 732; 60.417 identity in 192 aa overlap. ORF ftt0863c; LemA-like protein 873846 3191725 FTT_0863c Francisella tularensis subsp. tularensis SCHU S4 LemA-like protein YP_169865.1 873271 R 177416 CDS YP_169866.1 56707970 3191724 complement(873894..874790) 1 NC_006570.2 Similar to Q87XZ5 Transcriptional regulator, LysR family, from Pseudomonas syringae (308 aa). FASTA: opt: 591 Z-score: 726.5 E(): 1.4e-32 Smith-Waterman score: 591; 34.948 identity in 289 aa overlap. ORF ftt0864c; LysR family transcriptional regulator 874790 3191724 FTT_0864c Francisella tularensis subsp. tularensis SCHU S4 LysR family transcriptional regulator YP_169866.1 873894 R 177416 CDS YP_169867.1 56707971 3190911 876765..877508 1 NC_006570.2 ISFtu2. Transposase, member of the IS5 family. Identical to Q8GM03 transposase from Francisella tularensis (247 aa).; transposase 877508 isftu2 3190911 isftu2 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169867.1 876765 D 177416 CDS YP_169868.1 56707972 3191721 complement(879013..879378) 1 NC_006570.2 Similar to Q9RA93 ArsR from Sinorhizobium sp. As4 (115 aa). FASTA: opt: 185 Z-score: 259.0 bits: 53.3 E(): 1.6e-06 Smith-Waterman score: 185; 27.184 identity in 103 aa overlap. ORF ftt0868c; arsenical restistance operon repressor 879378 3191721 FTT_0868c Francisella tularensis subsp. tularensis SCHU S4 arsenical restistance operon repressor YP_169868.1 879013 R 177416 CDS YP_169869.1 56707973 3191720 879521..880174 1 NC_006570.2 ORF ftt0869; hypothetical protein 880174 3191720 FTT_0869 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169869.1 879521 D 177416 CDS YP_169870.1 56707974 3191718 complement(880186..880317) 1 NC_006570.2 ORF ftt0870c; hypothetical protein 880317 3191718 FTT_0870c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169870.1 880186 R 177416 CDS YP_169871.1 56707975 3192551 880494..881492 1 NC_006570.2 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 881492 gpsA 3192551 gpsA Francisella tularensis subsp. tularensis SCHU S4 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_169871.1 880494 D 177416 CDS YP_169872.1 56707976 3191717 complement(881493..882029) 1 NC_006570.2 ORF ftt0872c; hypothetical protein 882029 3191717 FTT_0872c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169872.1 881493 R 177416 CDS YP_169873.1 56707977 3191647 complement(882034..883404) 1 NC_006570.2 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 883404 radA 3191647 radA Francisella tularensis subsp. tularensis SCHU S4 DNA repair protein RadA YP_169873.1 882034 R 177416 CDS YP_169874.1 56707978 3191715 complement(883412..884182) 1 NC_006570.2 ORF ftt0874c; hypothetical protein 884182 3191715 FTT_0874c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169874.1 883412 R 177416 CDS YP_169875.1 56707979 3191716 complement(884179..884778) 1 NC_006570.2 Similar to YOHD_ECOLI (P33366) Hypothetical protein yohD from Escherichia coli (192 aa). FASTA: opt: 311 Z-score: 379.7 bits: 77.1 E(): 2.9e-13 Smith-Waterman score: 311; 24.870 identity (25.806 ungapped) in 193 aa overlap. ORF ftt0875c; hypothetical protein 884778 3191716 FTT_0875c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169875.1 884179 R 177416 CDS YP_169876.1 56707980 3190943 complement(884781..885839) 1 NC_006570.2 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 885839 aroC 3190943 aroC Francisella tularensis subsp. tularensis SCHU S4 chorismate synthase YP_169876.1 884781 R 177416 CDS YP_169877.1 56707981 3191714 complement(886004..886633) 1 NC_006570.2 ORF ftt0877c; hypothetical protein 886633 3191714 FTT_0877c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169877.1 886004 R 177416 CDS YP_169878.1 56707982 3191245 complement(886652..887164) 1 NC_006570.2 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 887164 msrB 3191245 msrB Francisella tularensis subsp. tularensis SCHU S4 methionine sulfoxide reductase B YP_169878.1 886652 R 177416 CDS YP_169879.1 56707983 3190715 887325..887882 1 NC_006570.2 superoxide dismutase (Cu-Zn) precusor. Identical to SODC_FRATU from F. tularensis LVS.; superoxide dismuate 887882 sodC 3190715 sodC Francisella tularensis subsp. tularensis SCHU S4 superoxide dismuate YP_169879.1 887325 D 177416 CDS YP_169880.1 56707984 3191712 complement(888650..890044) 1 NC_006570.2 Similar to AAP09927 Arginine permease from Bacillus cereus (474 aa). FASTA: opt: 1041 Z-score: 1224.1 E(): 2.5e-60 Smith-Waterman score: 1041; 35.604 identity in 455 aa overlap. ORF ftt0881c; amino acid permease 890044 3191712 FTT_0881c Francisella tularensis subsp. tularensis SCHU S4 amino acid permease YP_169880.1 888650 R 177416 CDS YP_169881.1 56707985 3190956 complement(891809..892999) 1 NC_006570.2 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 892999 aspC1 3190956 aspC1 Francisella tularensis subsp. tularensis SCHU S4 aspartate aminotransferase YP_169881.1 891809 R 177416 CDS YP_169882.1 56707986 3191707 893288..894067 1 NC_006570.2 Similar to Q8D6R6 Predicted Co/Zn/Cd cation transporter from Vibrio vulnificus (297 aa). FASTA: opt: 344 Z-score: 414.1 E(): 3.3e-15 Smith-Waterman score: 344; 25.296 identity in 253 aa overlap. ORF ftt0885; cation transporter 894067 3191707 FTT_0885 Francisella tularensis subsp. tularensis SCHU S4 cation transporter YP_169882.1 893288 D 177416 CDS YP_169883.1 56707987 3191706 894173..895822 1 NC_006570.2 Similar to P52118 DNA repair protein recN (Recombination protein (554 aa) fasta scores; opt: 1371 Z-score: 1221.7 E(): 3.4e-60 Smith-Waterman score: 1371; 39.674 identity in 552 aa overlap. ORF ftt0886; DNA repair protein RecN 895822 3191706 FTT_0886 Francisella tularensis subsp. tularensis SCHU S4 DNA repair protein RecN YP_169883.1 894173 D 177416 CDS YP_169884.1 56707988 3191705 complement(896394..896768) 1 NC_006570.2 ORF ftt0887c; hypothetical protein 896768 3191705 FTT_0887c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169884.1 896394 R 177416 CDS YP_169885.1 56707989 3191703 complement(896761..897357) 1 NC_006570.2 Similar to Q59607 Pilin precursor from Neisseria gonorrhoeae (169 aa). FASTA: opt: 244 Z-score: 305.7 E(): 3.5e-09 Smith-Waterman score: 244; 30.435 identity in 138 aa overlap. The pili fiber building block protein has a highly distinct primary structure; a short positively charged leader sequence, and a highly conserved and highly hydrophobic amino-terminal domain which forms the core of the pilus fiber; A variety of studies suggest that the invariant glycine (G) at -1 is required for prepilin cleavage and assembly and that the glutamate (E) at + 5 is essential for assembly and efficient N-terminal methylation but not cleavage. The region near the carboxy terminus is often hydrophilic and is stabilized by one or two disulfide bridges that may be involved in recognition of receptors. The genes with these characteristics are usually termed pilA, pilE, pilV, pilW, pilX and FimU. (Mattick John S.. 'Type IV Pili and twitching motility'. Annu. Rev. Microbiol. 2002. 56:289-314.) This protein has all the characteristics described above. ORF ftt0888c; Type IV pili fiber building block protein 897357 3191703 FTT_0888c Francisella tularensis subsp. tularensis SCHU S4 Type IV pili fiber building block protein YP_169885.1 896761 R 177416 CDS YP_169886.1 56707990 3191704 complement(898027..898467) 1 NC_006570.2 Similar to Q820M2 Fimbrial protein pilin:bacterial general secretion pathway protein H from Nitrosomonas europaea (136 aa). FASTA: opt: 216 Z-score: 280.1 E(): 1e-07 Smith-Waterman score: 218; 32.639 identity in 144 aa overlap. The pili fiber building block protein has a highly distinct primary structure; a short positively charged leader sequence, and a highly conserved and highly hydrophobic amino-terminal domain which forms the core of the pilus fiber; A variety of studies suggest that the invariant glycine (G) at -1 is required for prepilin cleavage and assembly and that the glutamate (E) at + 5 is essential for assembly and efficient N-terminal methylation but not cleavage. The region near the carboxy terminus is often hydrophilic and is stabilized by one or two disulfide bridges that may be involved in recognition of receptors. The genes with these characteristics are usually termed pilA, pilE, pilV, pilW, pilX and FimU. (Mattick John S.. 'Type IV Pili and twitching motility'. Annu. Rev. Microbiol. 2002. 56:289-314.) This protein has all the characteristics described above. ORF ftt0889c; Type IV pili fiber building block protein 898467 3191704 FTT_0889c Francisella tularensis subsp. tularensis SCHU S4 Type IV pili fiber building block protein YP_169886.1 898027 R 177416 CDS YP_169887.1 56707991 3191700 complement(898598..899005) 1 NC_006570.2 Similar to Q8Y1X9 Type 4 fimbrial pilin signal peptide protein from Ralstonia solanacearum (168 aa). FASTA: opt: 278 Z-score: 327.6 E(): 2.1e-10 Smith-Waterman score: 292; 38.095identity in 147 aa overlap. The pili fiber building block protein has a highly distinct primary structure; a short positively charged leader sequence, and a highly conserved and highly hydrophobic amino-terminal domain which forms the core of the pilus fiber; A variety of studies suggest that the invariant glycine (G) at -1 is required for prepilin cleavage and assembly and that the glutamate (E) at + 5 is essential for assembly and efficient N-terminal methylation but not cleavage. The region near the carboxy terminus is often hydrophilic and is stabilized by one or two disulfide bridges that may be involved in recognition of receptors. The genes with these characteristics are usually termed pilA, pilE, pilV, pilW, pilX and FimU. (Mattick John S.. 'Type IV Pili and twitching motility'. Annu. Rev. Microbiol. 2002. 56:289-314.) This protein has all the characteristics described above. ORF ftt0890c; Type IV pili fiber building block protein 899005 3191700 FTT_0890c Francisella tularensis subsp. tularensis SCHU S4 Type IV pili fiber building block protein YP_169887.1 898598 R 177416 CDS YP_169888.1 56707992 3191699 899389..900108 1 NC_006570.2 Similar to Q98NS1 Hypothetical protein mlr0012 from Rhizobium loti (244 aa). FASTA: opt: 327 Z-score: 404.4 bits: 82.2 E(): 1.2e-14 Smith-Waterman score: 327; 32.308 identity in 195 aa overlap. ORF ftt0891; hypothetical protein 900108 3191699 FTT_0891 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169888.1 899389 D 177416 CDS YP_169889.1 56707993 3191934 900247..901095 1 NC_006570.2 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase 901095 folD 3191934 folD Francisella tularensis subsp. tularensis SCHU S4 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase YP_169889.1 900247 D 177416 CDS YP_169890.1 56707994 3191664 901329..902372 1 NC_006570.2 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 902372 purM 3191664 purM Francisella tularensis subsp. tularensis SCHU S4 phosphoribosylaminoimidazole synthetase YP_169890.1 901329 D 177416 CDS YP_169891.1 56707995 3191239 902372..904684 1 NC_006570.2 Amino acids 1-327 (PurC) similar to AAR06292 SAICAR synthetase from Nicotiana tabacum (399 aa). BLAST: Expect = e-105 Identities = 187/322 (58), Positives = 236/322 (73), Gaps = 6/322 (1). Amino acids 328-770 (PurD) similar to ZP_00077753 Phosphoribosylamine-glycine ligase from Methanosarcina barkeri (433). BLAST: Expect = e-108 Identities = 204/436 (46), Positives = 285/436 (65), Gaps = 3/436 (0); fusion protein PurC/PurD 904684 purCD 3191239 purCD Francisella tularensis subsp. tularensis SCHU S4 fusion protein PurC/PurD YP_169891.1 902372 D 177416 CDS YP_169892.1 56707996 3191663 904688..905263 1 NC_006570.2 Similar to Q8DBC3 Folate-dependent phosphoribosylglycinamide formyltransferase from Vibrio vulnificus (212 aa). FASTA: opt: 530 Z-score: 633.0 E(): 2.1e-27 Smith-Waterman score: 530; 45.263 identity in 190 aa overlap.; phosphoribosylglycinamide formyltransferase 905263 purN 3191663 purN Francisella tularensis subsp. tularensis SCHU S4 phosphoribosylglycinamide formyltransferase YP_169892.1 904688 D 177416 CDS YP_169893.1 56707997 3191675 905380..905871 1 NC_006570.2 Similar to P72157 Phosphoribosylaminoimidazole carboxylase catalytic subunit from Psudomonas aeruginosa (163 aa). FASTA: opt: 719 Z-score: 894.1 E(): 6.6e-42 Smith-Waterman score: 719; 70.988 identity n 162 aa overlap; phosphoribosylaminoimidazole carboxylase catalyic subunit 905871 purE 3191675 purE Francisella tularensis subsp. tularensis SCHU S4 phosphoribosylaminoimidazole carboxylase catalyic subunit YP_169893.1 905380 D 177416 CDS YP_169894.1 56707998 3191666 905875..906972 1 NC_006570.2 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 906972 purK 3191666 purK Francisella tularensis subsp. tularensis SCHU S4 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_169894.1 905875 D 177416 CDS YP_169895.1 56707999 3191698 complement(906969..907322) 1 NC_006570.2 Similar to Q88N88 Conserved hypothetical protein TIGR002 from Pseudomonas putida (124 aa). FASTA: opt: 291 Z-score: 402.6 E(): 1.6e-14 Smith-Waterman score: 291; 38.938 identity in 113 aa overlap. ORF ftt0898c; hypothetical protein 907322 3191698 FTT_0898c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169895.1 906969 R 177416 CDS YP_169896.1 56708000 3191236 complement(907389..909410) 1 NC_006570.2 Similar to P27298 Oligopeptidase A from Escherichia coli (680 aa). FASTA: opt: 1936 Z-score: 2040.0 E(): 8.9e-106 Smith-Waterman score: 1936; 43.722 identity in 677 aa overlap.; oligopeptidase A 909410 prlC 3191236 prlC Francisella tularensis subsp. tularensis SCHU S4 oligopeptidase A YP_169896.1 907389 R 177416 CDS YP_169897.1 56708001 3191697 909502..909873 1 NC_006570.2 ORF ftt0900; hypothetical protein 909873 3191697 FTT_0900 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169897.1 909502 D 177416 CDS YP_169898.1 56708002 3191792 909954..910403 1 NC_006570.2 Paralog to conserved hypothetical lipoprotein lpnB.; lipoprotein 910403 lpnA 3191792 lpnA Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_169898.1 909954 D 177416 CDS YP_169899.1 56708003 3191696 910562..911041 1 NC_006570.2 paralog of FTT0903 ORF ftt0902; hypothetical protein 911041 3191696 FTT_0902 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169899.1 910562 D 177416 CDS YP_169900.1 56708004 3191693 911141..911644 1 NC_006570.2 paralog of FTT0902 ORF ftt0903; hypothetical protein 911644 3191693 FTT_0903 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169900.1 911141 D 177416 CDS YP_169901.1 56708005 3190834 911677..912144 1 NC_006570.2 Similar to P18149 17 kDa major membrane protein precursor from Francisella tularensis ssp. holarctica strain LVS (149 aa). FASTA: opt: 274 Z-score: 359.1 E(): 4.1e-12 Smith-Waterman score: 274; 32.468 identity (33.5570ngapped) in 154 aa overlap. Paralog to conserved hypothetical lipoprotein lpnA.; lipoprotein 912144 lpnB 3190834 lpnB Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_169901.1 911677 D 177416 CDS YP_169902.1 56708006 3191692 912217..913659 1 NC_006570.2 Similar to Q8KQ19 PilO from Pseudomonas aeruginosa (461 aa). FASTA: opt: 283 Z-score: 329.7 E(): 1.6e-10 Smith-Waterman score: 283; 25.284 identity in 352 aa overlap. PilO is required for glycosylation of Pseudomonas aeruginosa pilin. ORF ftt0905; Type IV pili glycosylation protein 913659 3191692 FTT_0905 Francisella tularensis subsp. tularensis SCHU S4 Type IV pili glycosylation protein YP_169902.1 912217 D 177416 CDS YP_169903.1 56708007 3190793 complement(913713..916007) 1 NC_006570.2 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining; maintains net negative superhelicity; DNA topoisomerase I 916007 topA 3190793 topA Francisella tularensis subsp. tularensis SCHU S4 DNA topoisomerase I YP_169903.1 913713 R 177416 CDS YP_169904.1 56708008 3191395 916206..916847 1 NC_006570.2 Similar to Q9F260 Partition protein from Actinobacillus actinomycetemcomitans (213 aa). FASTA: opt: 286 Z-score: 339.2 E(): 4.8e-11 mith-Waterman score: 286; 29.245 identity in 212 aa overlap; chmomosome partition protein A 916847 parA 3191395 parA Francisella tularensis subsp. tularensis SCHU S4 chmomosome partition protein A YP_169904.1 916206 D 177416 CDS YP_169905.1 56708009 3191409 916840..917754 1 NC_006570.2 Similar to Q9CJA4 Chromosome partitioning protein from Lactococcus lactis (261 aa). FASTA: opt: 399 Z-score: 442.0 E(): 9e-17 Smith-Waterman score: 399; 33.333 identity in 264 aa overlap; chromosome partition protein B 917754 parB 3191409 parB Francisella tularensis subsp. tularensis SCHU S4 chromosome partition protein B YP_169905.1 916840 D 177416 CDS YP_169906.1 56708010 3191690 917768..918475 1 NC_006570.2 Similar to Q88LT5 Glutamine amidotransferase, class I from Pseudomonas putida (244 aa). FASTA: opt: 589 Z-score: 771.5 bits: 150.1 E(): 4.4e-35 Smith-Waterman score: 589; 36.325identity in 234 aa overlap. ORF ftt0909; glutamine amidotransferase 918475 3191690 FTT_0909 Francisella tularensis subsp. tularensis SCHU S4 glutamine amidotransferase YP_169906.1 917768 D 177416 CDS YP_169907.1 56708011 3191688 918478..919359 1 NC_006570.2 Weakly similar to Q8GNM7 Lysophospholipase A from Legionella pneumophila (309 aa). FASTA: 86 opt: 302 Z-score: 378.8 bits: 78.1 E(): 3.3e-13 Smith-Waterman score: 360; 29.795 identity in 292 aa overlap. ORF ftt0910; hypothetical protein 919359 3191688 FTT_0910 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169907.1 918478 D 177416 CDS YP_169908.1 56708012 3191687 919356..919946 1 NC_006570.2 Similar with Q87NK1 Hypothetical protein from Vibrio parahaemolyticus (195 aa) fasta scores; opt: 523 Z-score: 649.0 E(): 2.7e-28 Smith-Waterman score: 523; 42.857 identity in 189 aa overlap ORF ftt0911; hypothetical protein 919946 3191687 FTT_0911 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169908.1 919356 D 177416 CDS YP_169909.1 56708013 3191489 complement(920006..920626) 1 NC_006570.2 Similar to Q8EHM3 Ribosomal RNA large subunit methyltransferase J from Shewanella oneidensis (209 aa). FASTA: opt: 730 Z-score: 844.0 E(): 3.7e-39 Smith-Waterman score: 730; 53.202identity in 203 aa overlap; ribosomal large subunit methyltransferase J 920626 rrmJ 3191489 rrmJ Francisella tularensis subsp. tularensis SCHU S4 ribosomal large subunit methyltransferase J YP_169909.1 920006 R 177416 CDS YP_169910.1 56708014 3191683 920784..921251 1 NC_006570.2 ORF ftt0913; hypothetical protein 921251 3191683 FTT_0913 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169910.1 920784 D 177416 CDS YP_169911.1 56708015 3190811 complement(921246..921731) 1 NC_006570.2 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 921731 lspA 3190811 lspA Francisella tularensis subsp. tularensis SCHU S4 lipoprotein signal peptidase YP_169911.1 921246 R 177416 CDS YP_169912.1 56708016 3192543 complement(921718..924525) 1 NC_006570.2 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 924525 ileS 3192543 ileS Francisella tularensis subsp. tularensis SCHU S4 isoleucyl-tRNA synthetase YP_169912.1 921718 R 177416 CDS YP_169913.1 56708017 3191623 complement(924618..925538) 1 NC_006570.2 Similar to Q9CKF8 RibF from Pasteurella multocida (311 aa). FASTA: opt: 845 Z-score: 994.4 E(): 1.5e-47 Smith-Waterman score: 845; 44.481 identity in 308 aa overlap; riboflavin biosynthesis protein RibF 925538 ribF 3191623 ribF Francisella tularensis subsp. tularensis SCHU S4 riboflavin biosynthesis protein RibF YP_169913.1 924618 R 177416 CDS YP_169914.1 56708018 3192386 925689..927503 1 NC_006570.2 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 927503 maeA 3192386 maeA Francisella tularensis subsp. tularensis SCHU S4 malate dehydrogenase YP_169914.1 925689 D 177416 CDS YP_169915.1 56708019 3191684 927666..929339 1 NC_006570.2 ORF ftt0918; hypothetical protein 929339 3191684 FTT_0918 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169915.1 927666 D 177416 CDS YP_169916.1 56708020 3191682 929356..930801 1 NC_006570.2 ORF ftt0919; hypothetical protein 930801 3191682 FTT_0919 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169916.1 929356 D 177416 CDS YP_169917.1 56708021 3190914 join(930936..931262,931262..931720) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 931720 isftu1 3190914 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_169917.1 930936 D 177416 CDS YP_169918.1 56708022 3191679 932888..933442 1 NC_006570.2 Similarity to Q98JM3 Probable fatty acid hydroxylase from Rhizobium loti (164 aa). FASTA: opt: 305 Z-score: 383.8 E(): 1.6e-13 Smith-Waterman score: 305; 31.902 identity in 163 aa overlap. ORF ftt0922; fatty acid hydroxylase 933442 3191679 FTT_0922 Francisella tularensis subsp. tularensis SCHU S4 fatty acid hydroxylase YP_169918.1 932888 D 177416 CDS YP_169919.1 56708023 3192468 933517..935670 1 NC_006570.2 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 935670 rlmL 3192468 rlmL Francisella tularensis subsp. tularensis SCHU S4 23S rRNA m(2)G2445 methyltransferase YP_169919.1 933517 D 177416 CDS YP_169920.1 56708024 3192465 935772..936170 1 NC_006570.2 ORF ftt0924; hypothetical protein 936170 3192465 FTT_0924 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169920.1 935772 D 177416 CDS YP_169921.1 56708025 3191926 936175..937116 1 NC_006570.2 Similarity to P44787 Methionyl-tRNA formyltransferase from Haemophilus ducreyi (318 aa). FASTA: opt: 949 Z-score: 1086.2 E(): 1.2e-52 Smith-Waterman score: 958; 48.387 identity in 310 aa overlap; methionyl-tRNA formyltransferase 937116 fmt 3191926 fmt Francisella tularensis subsp. tularensis SCHU S4 methionyl-tRNA formyltransferase YP_169921.1 936175 D 177416 CDS YP_169922.1 56708026 3192106 937120..938094 1 NC_006570.2 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 938094 gshB 3192106 gshB Francisella tularensis subsp. tularensis SCHU S4 glutathione synthetase YP_169922.1 937120 D 177416 CDS YP_169923.1 56708027 3192422 938084..939379 1 NC_006570.2 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 939379 hemL 3192422 hemL Francisella tularensis subsp. tularensis SCHU S4 glutamate-1-semialdehyde aminotransferase YP_169923.1 938084 D 177416 CDS YP_169924.1 56708028 3192464 complement(939400..941067) 1 NC_006570.2 SImilar to Q8RD12 Beta-glucosidase-related glycosidases from Thermoanaerobacter tengcongensis (591 aa). FASTA: opt: 1047 Z-score: 1141.5 E(): 9.9e-56 Smith-Waterman score: 1062; 35.106 identity in 564 aa overlap. ORF ftt0928c; beta-glucosidase 941067 3192464 FTT_0928c Francisella tularensis subsp. tularensis SCHU S4 beta-glucosidase YP_169924.1 939400 R 177416 CDS YP_169925.1 56708029 3192459 942809..944068 1 NC_006570.2 Similar to Q89YS8 Glucose/galactose transporter from Bacteroides thetaiotaomicron (415 aa). FASTA: opt: 1125 Z-score: 1176.3 bits: 226.6 E(): 1.3e-57 Smith-Waterman score: 1125; 41.446 identity in 415 aa overlap ORF ftt0931; major facilitator transporter 944068 3192459 FTT_0931 Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_169925.1 942809 D 177416 CDS YP_169926.1 56708030 3192460 944103..944954 1 NC_006570.2 Similar to Q8A1Q9 ROK family transcriptional repressor from Bacteroides thetaiotaomicron (298 aa). FASTA: opt: 482 Z-score: 605.6 E(): 7.7e-26 Smith-Waterman score: 482; 30.769 identity in 286 aa overlap ORF ftt0932; ROK family protein 944954 3192460 FTT_0932 Francisella tularensis subsp. tularensis SCHU S4 ROK family protein YP_169926.1 944103 D 177416 CDS YP_169927.1 56708031 3190963 complement(945880..946557) 1 NC_006570.2 Similar to AAO90524 Dethiobiotin synthetase from Coxiella burnetii (242 aa). FASTA: opt: 464 Z-score: 551.2 E(): 7.5e-23 Smith-Waterman score: 464; 34.498 identity in 229 aa overlap; dethiobiotin synthetase 946557 bioD 3190963 bioD Francisella tularensis subsp. tularensis SCHU S4 dethiobiotin synthetase YP_169927.1 945880 R 177416 CDS YP_169928.1 56708032 3190965 complement(946561..947298) 1 NC_006570.2 Similar to AAO90525 Biotin synthesis protein BioC, from Coxiella burnetii (248 aa) FASTA: opt: 232 Z-score: 273.5 E(): 2.2e-07 Smith-Waterman score: 232; 23.293 identity in 249 aa overlap; biotin synthesis protein BioC 947298 bioC 3190965 bioC Francisella tularensis subsp. tularensis SCHU S4 biotin synthesis protein BioC YP_169928.1 946561 R 177416 CDS YP_169929.1 56708033 3190975 complement(947276..948403) 1 NC_006570.2 Similar to AAO90527 8-amino-7-oxononanoate synthase (384 aa) fasta scores; opt: 763 Z-score: 912.3 E(): 5.8e-43 Smith-Waterman score: 763; 39.053identity in 338 aa overlap; 8-amino-7-oxononanoate synthase 948403 bioF 3190975 bioF Francisella tularensis subsp. tularensis SCHU S4 8-amino-7-oxononanoate synthase YP_169929.1 947276 R 177416 CDS YP_169930.1 56708034 3190968 complement(948397..949338) 1 NC_006570.2 Similar to AAO90528 Biotin synthase from Coxiella burnetii (321 aa) FASTA: opt: 1220 Z-score: 1430.1 E(): 8.3e-72 Smith-Waterman score: 1220; 60.396 identity in 303 aa overlap; biotin synthase 949338 bioB 3190968 bioB Francisella tularensis subsp. tularensis SCHU S4 biotin synthase YP_169930.1 948397 R 177416 CDS YP_169931.1 56708035 3192333 949384..950715 1 NC_006570.2 Similar to AAO90529 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase from Coxiella burnetii (442 aa). FASTA: opt: 1486 Z-score: 1733.9 E(): 9.9e-89 Smith-Waterman score: 1486; 50.588 identity in 425 aa overlap; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 950715 bioA 3192333 bioA Francisella tularensis subsp. tularensis SCHU S4 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_169931.1 949384 D 177416 CDS YP_169932.1 56708036 3192404 complement(950825..951769) 1 NC_006570.2 catalyzes the formation of inosine from adenosine; adenosine deaminase 951769 add1 3192404 add1 Francisella tularensis subsp. tularensis SCHU S4 adenosine deaminase YP_169932.1 950825 R 177416 CDS YP_169933.1 56708037 3192457 complement(951917..952417) 1 NC_006570.2 Similar to Q88CI3 Conserved hypothetical protein from Pseudomonas putida (160 aa). FASTA: opt: 297 Z-score: 384.8 E(): 1.4e-13 Smith-Waterman score: 297; 32.653 identity in 147 aa overlap ORF ftt0940c; hypothetical protein 952417 3192457 FTT_0940c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169933.1 951917 R 177416 CDS YP_169934.1 56708038 3192456 complement(952433..953353) 1 NC_006570.2 Similar to Q97VW1 Lipase (lipP-1) from Sulfolobus solfataricus (305 aa). FASTA: opt: 488 Z-score: 622.4 E(): 8.9e-27 Smith-Waterman score: 488; 32.990 identity in 291 aa overlap. ORF ftt0941c; lipase/esterase 953353 3192456 FTT_0941c Francisella tularensis subsp. tularensis SCHU S4 lipase/esterase YP_169934.1 952433 R 177416 CDS YP_169935.1 56708039 3191528 complement(953366..954631) 1 NC_006570.2 Similar to Q821E2 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase from Chlamydophila caviae (447 aa). FASTA: opt: 517 Z-score: 602.2 E(): 1.2e-25 Smith-Waterman score: 604; 30.664 identity in 437 aa overlap; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 954631 folK 3191528 folK Francisella tularensis subsp. tularensis SCHU S4 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_169935.1 953366 R 177416 CDS YP_169936.1 56708040 3191941 complement(954633..954986) 1 NC_006570.2 Similar to O84620 Probable dihydroneopterin aldolase (124 aa) fasta scores; opt: 191 Z-score: 262.4 E(): 9.2e-07 Smith-Waterman score: 191; 30.189identity in 106 aa overlap; dihydroneopterin aldolase 954986 folB 3191941 folB Francisella tularensis subsp. tularensis SCHU S4 dihydroneopterin aldolase YP_169936.1 954633 R 177416 CDS YP_169937.1 56708041 3192455 955056..956438 1 NC_006570.2 Similar to Q9CHK3 O-succinylbenzoic acid-CoA ligase from Lactococcus lactis (420 aa). opt: 373 Z-score: 423.0 E(): 1e-15 Smith-Waterman score: 434; 27.692 identity in 390 aa overlap ORF ftt0944; AMP-binding protein 956438 3192455 FTT_0944 Francisella tularensis subsp. tularensis SCHU S4 AMP-binding protein YP_169937.1 955056 D 177416 CDS YP_169938.1 56708042 3192454 956431..958194 1 NC_006570.2 Similar to Q8ESD8 Para-aminobenzoate synthase component II (585 aa) fasta scores; opt: 1108 Z-score: 1235.5 E(): 5.7e-61 Smith-Waterman score: 1108; 33.851 identity in 579 aa overlap. ORF ftt0945; chorismate binding family protein 958194 3192454 FTT_0945 Francisella tularensis subsp. tularensis SCHU S4 chorismate binding family protein YP_169938.1 956431 D 177416 CDS YP_169939.1 56708043 3190985 958196..958750 1 NC_006570.2 Similarity to Q972A0 anthranilate synthase component from Sulfolobus tokodaii (193 aa). FASTA: opt: 499 Z-score: 620.3 E(): 1.1e-26 Smith-Waterman score: 499; 40.741 identity in 189 aa overlap. Closely related to pabA proteins as they possess a shared domain feature; anthranilate synthase subunit II 958750 trpG1 3190985 trpG1 Francisella tularensis subsp. tularensis SCHU S4 anthranilate synthase subunit II YP_169939.1 958196 D 177416 CDS YP_169940.1 56708044 3192451 complement(959971..961035) 1 NC_006570.2 Similar to Q92QZ5 oxidoreductase protein from Rhizobium meliloti (347 aa). FASTA: opt: 1125 Z-score: 1304.5 E(): 8.2e-65 Smith-Waterman score: 1125; 50.140 identity in 357 aa overlap. pseudogene: flanked by pseudogenes ORF ftt0948c; aldo/keto reductase 961035 3192451 FTT_0948c Francisella tularensis subsp. tularensis SCHU S4 aldo/keto reductase YP_169940.1 959971 R 177416 CDS YP_169941.1 56708045 3191935 complement(963398..964018) 1 NC_006570.2 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 964018 folE 3191935 folE Francisella tularensis subsp. tularensis SCHU S4 GTP cyclohydrolase I YP_169941.1 963398 R 177416 CDS YP_169942.1 56708046 3191629 964145..965470 1 NC_006570.2 Similar to Q8D6C6 Superfamily II DNA and RNA helicase from Vibrio vulnificus (509 aa). FASTA: opt: 1533 Z-score: 1649.9 E(): 4.8e-84 Smith-Waterman score: 1533; 56.036 identity in 439 aa overlap; ATP-dependent RNA helicase RhlE 965470 rhlE 3191629 rhlE Francisella tularensis subsp. tularensis SCHU S4 ATP-dependent RNA helicase RhlE YP_169942.1 964145 D 177416 CDS YP_169943.1 56708047 3192447 complement(965467..967008) 1 NC_006570.2 Similar to Q9KTB5 Proton/peptide symporter family protein from Vibrio cholerae (514 aa). FASTA: opt: 1329 Z-score: 1443.3 E(): 1.5e-72 Smith-Waterman score: 1329; 42.629identity in 502 aa overlap. ORF ftt0953c; proton-dependent oligopeptide transport (POT) family protein 967008 3192447 FTT_0953c Francisella tularensis subsp. tularensis SCHU S4 proton-dependent oligopeptide transport (POT) family protein YP_169943.1 965467 R 177416 CDS YP_169944.1 56708048 3192448 complement(967146..967466) 1 NC_006570.2 Similar to O29392 Hypothetical protein AF0869 from Archaeoglobus fulgidus (108 aa). FASTA: opt: 272 Z-score: 377.5 E(): 3.9e-13 Smith-Waterman score: 272; 42.056 identity in 107 aa overlap ORF ftt0954c; hypothetical protein 967466 3192448 FTT_0954c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169944.1 967146 R 177416 CDS YP_169945.1 56708049 3192553 complement(967477..968838) 1 NC_006570.2 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 968838 gor 3192553 gor Francisella tularensis subsp. tularensis SCHU S4 glutathione reductase YP_169945.1 967477 R 177416 CDS YP_169946.1 56708050 3192446 complement(968876..969595) 1 NC_006570.2 Similar to AAO50751 (Q86L42) Hypothetical protein from Dictyostelium discoideum (239 aa). FASTA: opt: 229 Z-score: 273.3 E(): 2.3e-07 Smith-Waterman score: 253; 29.437 identity in 231 aa overlap ORF ftt0956c; hypothetical protein 969595 3192446 FTT_0956c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169946.1 968876 R 177416 CDS YP_169947.1 56708051 3192445 complement(969595..970098) 1 NC_006570.2 Similar to Q83YE2 Shy8 from Streptomyces hygroscopicus (163 aa). FASTA: opt: 343 Z-score: 413.4 bits: 82.8 E(): 3.9e-15 Smith-Waterman score: 343; 36.420 identity in 162 aa overlap. ORF ftt0957c; hypothetical protein 970098 3192445 FTT_0957c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169947.1 969595 R 177416 CDS YP_169948.1 56708052 3192443 complement(970101..970808) 1 NC_006570.2 Similar to Q9HWL9 Probable short-chain dehydrogenase from Pseudomonas aeruginosa (238 aa). FASTA: opt: 848 Z-score: 1032.8 E(): 1.1e-49 Smith-Waterman score: 848; 55.932 identity in 236 aa overlap ORF ftt0958c; short chain dehydrogenase 970808 3192443 FTT_0958c Francisella tularensis subsp. tularensis SCHU S4 short chain dehydrogenase YP_169948.1 970101 R 177416 CDS YP_169949.1 56708053 3192119 complement(970829..971617) 1 NC_006570.2 Similar to Q83EM1 Exodeoxyribonuclease III from Coxiella burnetii (259 aa). FASTA: opt: 991 Z-score: 1173.5 E(): 1.6e-57 Smith-Waterman score: 991; 54.789 identity in 261 aa overlap; exodeoxyribonuclease III 971617 xthA 3192119 xthA Francisella tularensis subsp. tularensis SCHU S4 exodeoxyribonuclease III YP_169949.1 970829 R 177416 CDS YP_169950.1 56708054 3192444 971901..972884 1 NC_006570.2 Simiar to Q8EAC2 Conserved hypothetical protein Shewanella oneidensis (371 aa). FASTA: opt: 607 Z-score: 717.9 E(): 3.9e-32 Smith-Waterman score: 607; 32.622 identity in 328 aa overlap ORF ftt0960; hypothetical protein 972884 3192444 FTT_0960 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169950.1 971901 D 177416 CDS YP_169951.1 56708055 3191872 972892..973482 1 NC_006570.2 Similar to P40717 Modulator of drug activity B from Escherichia coli (193 aa). FASTA: opt: 900 Z-score: 1129.6 E(): 4.5e-55 Smith-Waterman score: 900; 63.542 identity in 192 aa overlap.; modulator of drug activity B 973482 mdaB 3191872 mdaB Francisella tularensis subsp. tularensis SCHU S4 modulator of drug activity B YP_169951.1 972892 D 177416 CDS YP_169952.1 56708056 3192441 973598..974260 1 NC_006570.2 Similar to Q87Z85 ThiJ/PfpI family protein from Pseudomonas syringae (225 aa). FASTA: opt: 570 Z-score: 665.3 E(): 3.3e-29 Smith-Waterman score: 570; 38.991 identity in 218 aa overlap ORF ftt0962; ThiJ/PfpI family protein 974260 3192441 FTT_0962 Francisella tularensis subsp. tularensis SCHU S4 ThiJ/PfpI family protein YP_169952.1 973598 D 177416 CDS YP_169953.1 56708057 3190950 complement(974330..975442) 1 NC_006570.2 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 975442 aroG 3190950 aroG Francisella tularensis subsp. tularensis SCHU S4 phospho-2-dehydro-3-deoxyheptonate aldolase YP_169953.1 974330 R 177416 CDS YP_169954.1 56708058 3191883 complement(975474..976850) 1 NC_006570.2 Similar to Q9CLN6 Ffh from Pasteurella multocida (458 aa). FASTA: opt: 1851 Z-score: 1789.9 E(): 7.5e-92 Smith-Waterman score: 1851; 61.790 identity in 458 aa overlap; signal recognition particle protein, Ffh 976850 ffh 3191883 ffh Francisella tularensis subsp. tularensis SCHU S4 signal recognition particle protein, Ffh YP_169954.1 975474 R 177416 CDS YP_169955.1 56708059 3192440 complement(977194..978099) 1 NC_006570.2 Similar to Q928M9 Hypothetical protein lin2503 from Listeria innocua (279 aa). FASTA: opt: 733 Z-score: 821.7 E(): 6.4e-38 Smith-Waterman score: 733; 41.852 identity in 270 aa overlap. ORF ftt0965c; hypothetical protein 978099 3192440 FTT_0965c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169955.1 977194 R 177416 CDS YP_169956.1 56708060 3191552 978193..978411 1 NC_006570.2 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 978411 infA 3191552 infA Francisella tularensis subsp. tularensis SCHU S4 translation initiation factor IF-1 YP_169956.1 978193 D 177416 CDS YP_169957.1 56708061 3192433 complement(979373..980788) 1 NC_006570.2 Similar to Q83BZ0 Amino acid antiporter from Coxiella burnetii (474 aa). FASTA: 432 opt: 1275 Z-score: 1361.2 E(): 6.3e-68 Smith-Waterman score: 1275; 40.171 identity in 468 aa overlap. ORF ftt0968c; amino acid antiporter 980788 3192433 FTT_0968c Francisella tularensis subsp. tularensis SCHU S4 amino acid antiporter YP_169957.1 979373 R 177416 CDS YP_169958.1 56708062 3191475 complement(980853..982226) 1 NC_006570.2 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 982226 trkA 3191475 trkA Francisella tularensis subsp. tularensis SCHU S4 potassium transporter peripheral membrane protein YP_169958.1 980853 R 177416 CDS YP_169959.1 56708063 3191852 982379..982789 1 NC_006570.2 Similar to Q8PIG4 Hypothetical protein XAC2934 from Xanthomonas axonopodis (152 aa). FASTA: opt: 281 Z-score: 360.3 E(): 3.2e-12 Smith-Waterman score: 281; 33.588 identity in 131 aa overlap ORF ftt0970; hypothetical protein 982789 3191852 FTT_0970 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169959.1 982379 D 177416 CDS YP_169960.1 56708064 3190927 982796..984241 1 NC_006570.2 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase 984241 3190927 FTT_0971 Francisella tularensis subsp. tularensis SCHU S4 cysteine desulfurase YP_169960.1 982796 D 177416 CDS YP_169961.1 56708065 3190906 984280..985029 1 NC_006570.2 Similar to Q8PIG2 ABC transporter ATP-binding protein from Xanthomonas axonopodis (254 aa). FASTA: opt: 1080 Z-score: 1117.5 E(): 2.1e-54 Smith-Waterman score: 1080; 65.041 identity in 246 aa overlap. ORF ftt0972; ABC transporter ATP-binding protein 985029 3190906 FTT_0972 Francisella tularensis subsp. tularensis SCHU S4 ABC transporter ATP-binding protein YP_169961.1 984280 D 177416 CDS YP_169962.1 56708066 3190904 985033..986187 1 NC_006570.2 Similar to Q83BX9 Hypothetical protein CBU1358 Coxiella burnetii (426 aa). FASTA: opt: 433 Z-score: 493.2 E(): 1.3e-19 Smith-Waterman score: 460; 29.282 identity in 362 aa overlap ORF ftt0973; hypothetical protein 986187 3190904 FTT_0973 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169962.1 985033 D 177416 CDS YP_169963.1 56708067 3190902 987156..987845 1 NC_006570.2 Weakly similar to Q83CZ8 Hypothetical protein Coxiella burnetii (227 aa) 76 opt: 235 Z-score: 276.0 bits: 58.3 E(): 1.8e-07 Smith-Waterman score: 235; 25.000 identity in 236 aa overlap. ORF ftt0975; hypothetical protein 987845 3190902 FTT_0975 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169963.1 987156 D 177416 CDS YP_169964.1 56708068 3191003 987849..988175 1 NC_006570.2 Similar to P37395 Thioredoxin from Cyanidium caldarium (107 aa) fasta scores; opt: 333 Z-score: 452.0 E(): 2.5e-17 Smith-Waterman score: 333; 45.098identity in 102 aa overlap; thioredoxin 988175 trxA2 3191003 trxA2 Francisella tularensis subsp. tularensis SCHU S4 thioredoxin YP_169964.1 987849 D 177416 CDS YP_169965.1 56708069 3190901 complement(988574..988867) 1 NC_006570.2 Similar to Q89DD5 Bsl7504 protein from Bradyrhizobium japonicum (99 aa). FASTA: opt: 209 Z-score: 292.0 E(): 2e-08 Smith-Waterman score: 209; 38.462 identity in 91 aa overlap ORF ftt0977c; hypothetical protein 988867 3190901 FTT_0977c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169965.1 988574 R 177416 CDS YP_169966.1 56708070 3190898 complement(988871..989476) 1 NC_006570.2 ORF ftt0978c; hypothetical protein 989476 3190898 FTT_0978c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169966.1 988871 R 177416 CDS YP_169967.1 56708071 3190899 complement(989530..990897) 1 NC_006570.2 amino-acid permease, similarity to P39137 Amino-acid permease rocE from Bacillus subtilis (467 aa). FASTA: opt: 1272 Z-score: 1431.9 E(): 6.6e-72 Smith-Waterman score: 1272; 40.919 identity in 457 aa overlap. ORF ftt0979c; amino-acid permease 990897 3190899 FTT_0979c Francisella tularensis subsp. tularensis SCHU S4 amino-acid permease YP_169967.1 989530 R 177416 CDS YP_169968.1 56708072 3190897 991132..992373 1 NC_006570.2 Similar to Q8UKI4 Aminotransferase, class II from Agrobacterium tumefaciens (413 aa). FASTA: opt: 486 Z-score: 559.2 E(): 2.7e-23 Smith-Waterman score: 554; 28.493 identity in 365 aa overlap ORF ftt0980; hypothetical protein 992373 3190897 FTT_0980 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169968.1 991132 D 177416 CDS YP_169969.1 56708073 3190896 992706..993836 1 NC_006570.2 Weak homology to two-component sensory protein. ORF ftt0981; hypothetical protein 993836 3190896 FTT_0981 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169969.1 992706 D 177416 CDS YP_169970.1 56708074 3190895 993929..994072 1 NC_006570.2 ORF ftt0982; hypothetical protein 994072 3190895 FTT_0982 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169970.1 993929 D 177416 CDS YP_169972.1 56708076 3192063 complement(994786..995196) 1 NC_006570.2 Similar to Q87SF6 Mutator MutT protein from Vibrio parahaemolyticus (132 aa). FASTA: opt: 268 Z-score: 340.9 E(): 3.9e-11 Smith-Waterman score: 268; 29.545identity in 132 aa overlap.; Mutator protein 995196 mutT 3192063 mutT Francisella tularensis subsp. tularensis SCHU S4 Mutator protein YP_169972.1 994786 R 177416 CDS YP_169973.1 56708077 3190893 995235..995819 1 NC_006570.2 Similar to Q8EBZ9 Conserved hypothetical protein from Shewanella oneidensis (187 aa). FASTA: opt: 386 Z-score: 477.0 E(): 1e-18 Smith-Waterman score: 386; 36.022 identity in 186 aa overlap ORF ftt0985; hypothetical protein 995819 3190893 FTT_0985 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169973.1 995235 D 177416 CDS YP_169974.1 56708078 3190892 995821..996231 1 NC_006570.2 Similar to Q9L3I7 Holliday junction resolvase from Aeromonas hydrophila (140 aa). FASTA: opt: 336 Z-score: 430.0 E(): 4.7e-16 Smith-Waterman score: 336; 36.567 identity in 134 aa overlap Holliday junction resolvase predicted in other proteins ORF ftt0986; hypothetical protein 996231 3190892 FTT_0986 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169974.1 995821 D 177416 CDS YP_169975.1 56708079 3190891 996324..996521 1 NC_006570.2 ORF ftt0987; hypothetical protein 996521 3190891 FTT_0987 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169975.1 996324 D 177416 CDS YP_169976.1 56708080 3190889 996644..996832 1 NC_006570.2 ORF ftt0988; hypothetical protein 996832 3190889 FTT_0988 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169976.1 996644 D 177416 CDS YP_169977.1 56708081 3190890 996926..998821 1 NC_006570.2 Similar to Q9I271 Hypothetical protein PA2044 from Pseudomonas aeruginosa (624 aa). FASTA: opt: 447 Z-score: 484.0 E(): 4.2e-19 Smith-Waterman score: 447; 22.203 identity in 572 aa overlap. ORF ftt0989; hypothetical protein 998821 3190890 FTT_0989 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169977.1 996926 D 177416 CDS YP_169978.1 56708082 3190983 998929..1001370 1 NC_006570.2 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 1001370 leuS 3190983 leuS Francisella tularensis subsp. tularensis SCHU S4 leucyl-tRNA synthetase YP_169978.1 998929 D 177416 CDS YP_169979.1 56708083 3190888 1001378..1001953 1 NC_006570.2 ORF ftt0991; lipoprotein 1001953 3190888 FTT_0991 Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_169979.1 1001378 D 177416 CDS YP_169980.1 56708084 3190887 1002014..1003204 1 NC_006570.2 Similar to Q8A7A2 membrane protein from Bacteroides thetaiotaomicron (391 aa). FASTA: opt: 908 Z-score: 1062.3 E(): 2.6e-51 Smith-Waterman score: 908; 37.637 identity in 364 aa overlap. ORF ftt0992; hypothetical protein 1003204 3190887 FTT_0992 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169980.1 1002014 D 177416 CDS YP_169981.1 56708085 3191500 complement(1003211..1003777) 1 NC_006570.2 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1003777 dcd 3191500 dcd Francisella tularensis subsp. tularensis SCHU S4 deoxycytidine triphosphate deaminase YP_169981.1 1003211 R 177416 CDS YP_169982.1 56708086 3190886 complement(1003789..1004649) 1 NC_006570.2 Similar to Q8XWU1 Probable MRP protein ATP-binding from Ralstonia solanacearum. (362 aa). FASTA: opt: 1008 Z-score: 1105.3 E(): 1e-53 Smith-Waterman score: 1008; 52.688 identity in 279 aa overlap. ORF ftt0994c; MRP like protein 1004649 3190886 FTT_0994c Francisella tularensis subsp. tularensis SCHU S4 MRP like protein YP_169982.1 1003789 R 177416 CDS YP_169983.1 56708087 3190885 1004723..1005955 1 NC_006570.2 Similarity to Q8UDH1 MFS permease[proline/betaine] from Agrobacterium tumefaciens (443 aa). FASTA: opt: 727 Z-score: 824.0 E(): 4.8e-38 Smith-Waterman score: 828; 35.507identity in 414 aa overlap ORF ftt0995; major facilitator transporter 1005955 3190885 FTT_0995 Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_169983.1 1004723 D 177416 CDS YP_169984.1 56708088 3192157 1007525..1008955 1 NC_006570.2 Similar to P71040 Probable cardiolipin synthetase 2 from Bacillus subtilis (482 aa). FASTA: opt: 835 Z-score: 944.7 E(): 9.1e-45 Smith-Waterman score: 835; 32.525 identity in 495 aa overlap; cardiolipin synthetase 1008955 ybhO 3192157 ybhO Francisella tularensis subsp. tularensis SCHU S4 cardiolipin synthetase YP_169984.1 1007525 D 177416 CDS YP_169985.1 56708089 3192073 1009121..1010110 1 NC_006570.2 ORF ftt0998; hypothetical protein 1010110 3192073 FTT_0998 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169985.1 1009121 D 177416 CDS YP_169986.1 56708090 3191886 complement(1010878..1012104) 1 NC_006570.2 Similar to Q8FUU8 Cobalamin synthesis protein/P47K family protein from Brucella suis (400 aa). FASTA: opt: 1643 Z-score: 1956.7 E(): 4.3e-101 Smith-Waterman score: 1643; 58.396 identity in 399 aa overlap.; cobalamin (vitamin B12) synthesis protein/P47K family protein 1012104 cobS 3191886 cobS Francisella tularensis subsp. tularensis SCHU S4 cobalamin (vitamin B12) synthesis protein/P47K family protein YP_169986.1 1010878 R 177416 CDS YP_169987.1 56708091 3192069 1012246..1012677 1 NC_006570.2 Similar to Q8ZJ15 regulatory protein from Yersinia pestis (169 aa). FASTA: opt: 313 Z-score: 406.8 E(): 9.2e-15 Smith-Waterman score: 313; 36.429 identity in 140 aa overlap. ORF ftt1001; regulatory protein 1012677 3192069 FTT_1001 Francisella tularensis subsp. tularensis SCHU S4 regulatory protein YP_169987.1 1012246 D 177416 CDS YP_169988.1 56708092 3191133 complement(1012720..1015092) 1 NC_006570.2 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1015092 pheT 3191133 pheT Francisella tularensis subsp. tularensis SCHU S4 phenylalanyl-tRNA synthetase subunit beta YP_169988.1 1012720 R 177416 CDS YP_169989.1 56708093 3191372 complement(1015113..1016126) 1 NC_006570.2 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1016126 pheS 3191372 pheS Francisella tularensis subsp. tularensis SCHU S4 phenylalanyl-tRNA synthetase subunit alpha YP_169989.1 1015113 R 177416 CDS YP_169990.1 56708094 3192070 complement(1016212..1017105) 1 NC_006570.2 Similar to Q9RX03 Hypothetical protein DR0512 from Deinococcus radiodurans (301 aa). Similar to opt: 577 Z-score: 644.6 E(): 5.1e-28 Smith-Waterman score: 577; 33.094 identity in 278 aa overlap. ORF ftt1004c; hypothetical protein 1017105 3192070 FTT_1004c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169990.1 1016212 R 177416 CDS YP_169991.1 56708095 3191273 complement(1017130..1018605) 1 NC_006570.2 Similar to Q8X5Q8 transport protein from Escherichia coli (489 aa). FASTA: opt: 1050 Z-score: 1137.7 E(): 1.8e-55 Smith-Waterman score: 1050; 35.569 identity in 492 aa overlap.; proton-dependent oligopeptide transporter (POT) family protein 1018605 yhiP 3191273 yhiP Francisella tularensis subsp. tularensis SCHU S4 proton-dependent oligopeptide transporter (POT) family protein YP_169991.1 1017130 R 177416 CDS YP_008492912.1 537470115 16744728 complement(1018628..1018813) 1 NC_006570.2 ABC transporter ATP-binding protein 1018813 16744728 FTT_0005a Francisella tularensis subsp. tularensis SCHU S4 ABC transporter ATP-binding protein YP_008492912.1 1018628 R 177416 CDS YP_169992.1 56708096 3192068 1018849..1020057 1 NC_006570.2 ORF ftt1006; hypothetical protein 1020057 3192068 FTT_1006 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169992.1 1018849 D 177416 CDS YP_169995.1 56708099 3192064 1021117..1021653 1 NC_006570.2 ORF ftt1009; hypothetical protein 1021653 3192064 FTT_1009 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169995.1 1021117 D 177416 CDS YP_169996.1 56708100 3192061 1021668..1021871 1 NC_006570.2 Similar to Q81BZ8 Transcriptional regulator,Cro/CI family protein from Bacillus cereus (strain ATCC 14579 / DSM 31) (71 aa). FASTA: opt: 263 Z-score: 391.6 E(): 6.4e-14 Smith-Waterman score: 263; 60.606 identity in 66 aa overlap. ORF ftt1010; helix-turn-helix family protein 1021871 3192061 FTT_1010 Francisella tularensis subsp. tularensis SCHU S4 helix-turn-helix family protein YP_169996.1 1021668 D 177416 CDS YP_169997.1 56708101 3192062 1021983..1022171 1 NC_006570.2 ORF ftt1011; hypothetical protein 1022171 3192062 FTT_1011 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_169997.1 1021983 D 177416 CDS YP_169998.1 56708102 3191291 complement(1023158..1024204) 1 NC_006570.2 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1024204 ruvB 3191291 ruvB Francisella tularensis subsp. tularensis SCHU S4 Holliday junction DNA helicase RuvB YP_169998.1 1023158 R 177416 CDS YP_169999.1 56708103 3192059 complement(1024268..1024993) 1 NC_006570.2 Similar to YWFD_BACSU (P39640) Hypothetical oxidoreductase ywfD from Bacillus subtilis (255 aa). FASTA: opt: 410 Z-score: 474.7 E(): 1.5e-18 Smith-Waterman score: 471; 38.710 identity in 248 aa overlap. ORF ftt1014c; short chain dehydrogenase family protein 1024993 3192059 FTT_1014c Francisella tularensis subsp. tularensis SCHU S4 short chain dehydrogenase family protein YP_169999.1 1024268 R 177416 CDS YP_170000.1 56708104 3192056 1025111..1025701 1 NC_006570.2 ORF ftt1015; hypothetical protein 1025701 3192056 FTT_1015 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170000.1 1025111 D 177416 CDS YP_170001.1 56708105 3192058 complement(1025711..1026340) 1 NC_006570.2 Similar to Q9JQY7 lipase (GDSL lipase family protein) from Neisseria meningitidis (213 aa). FASTA: opt: 358 Z-score: 439.3 E(): 1.4e-16 Smith-Waterman score: 358; 32.203 identity in 177 aa overlap. ORF ftt1016c; GDSL-like lipase/acylhydrolase family protein 1026340 3192058 FTT_1016c Francisella tularensis subsp. tularensis SCHU S4 GDSL-like lipase/acylhydrolase family protein YP_170001.1 1025711 R 177416 CDS YP_170002.1 56708106 3192055 complement(1026362..1026697) 1 NC_006570.2 ORF ftt1017c; hypothetical protein 1026697 3192055 FTT_1017c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170002.1 1026362 R 177416 CDS YP_170003.1 56708107 3191556 complement(1026713..1028560) 1 NC_006570.2 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1028560 dxs 3191556 dxs Francisella tularensis subsp. tularensis SCHU S4 1-deoxy-D-xylulose-5-phosphate synthase YP_170003.1 1026713 R 177416 CDS YP_170004.1 56708108 3191098 complement(1028642..1030192) 1 NC_006570.2 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1030192 guaA 3191098 guaA Francisella tularensis subsp. tularensis SCHU S4 GMP synthase YP_170004.1 1028642 R 177416 CDS YP_170005.1 56708109 3192053 complement(1030280..1031827) 1 NC_006570.2 Similar to Q83EA0 Amino acid permease family protein from Coxiella burnetii (531 aa). FASTA: opt: 925 Z-score: 996.3 E(): 1.3e-47 Smith-Waterman score: 947; 29.379 identity in 531 aa overlap. ORF ftt1020c; amino acid permease 1031827 3192053 FTT_1020c Francisella tularensis subsp. tularensis SCHU S4 amino acid permease YP_170005.1 1030280 R 177416 CDS YP_170006.1 56708110 3190996 complement(1031880..1032656) 1 NC_006570.2 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1032656 truA 3190996 truA Francisella tularensis subsp. tularensis SCHU S4 tRNA pseudouridine synthase A YP_170006.1 1031880 R 177416 CDS YP_170007.1 56708111 3192052 complement(1032659..1034491) 1 NC_006570.2 Similar to Y125_PYRHO (O57865) Hypothetical protein PH0125 from Pyrococcus horikoshii (257 aa) (from 1-260). FASTA: opt: 520 Z-score: 632.1 E(): 2.6e-27 Smith-Waterman score: 520; 35.600 identity in 250 aa overlap AND Q97VT8 Lipase (lipP-2) from Sulfolobus solfataricus (311 aa) (from 300-610). FASTA: opt: 613 Z-score: 743.7 E(): 1.6e-33 Smith-Waterman score: 613; 34.586 identity in 266 aa overlap Possible merged protein due to a missing stop codon between 2 CDSs? ORF ftt1022c; hypothetical protein 1034491 3192052 FTT_1022c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170007.1 1032659 R 177416 CDS YP_170008.1 56708112 3192050 complement(1034504..1035097) 1 NC_006570.2 Similar to Q8EGL6 Fumarylacetoacetate hydrolase family protein from Shewanella oneidensis (208 aa). FASTA: opt: 599 Z-score: 746.5 E(): 1.1e-33 Smith-Waterman score: 599; 51.913 identity in 183 aa overlap. ORF ftt1023c; fumarylacetoacetate hydrolase family protein 1035097 3192050 FTT_1023c Francisella tularensis subsp. tularensis SCHU S4 fumarylacetoacetate hydrolase family protein YP_170008.1 1034504 R 177416 CDS YP_170009.1 56708113 3192168 complement(1035146..1035877) 1 NC_006570.2 Similar to Q8ZB44 Probable ABC transporter ATP-binding protein from Yersinia pestis (241 aa). FASTA: opt: 1091 Z-score: 1233.5 E(): 8.2e-61 Smith-Waterman score: 1091; 65.690 identity in 239 aa overlap.; ABC transporter ATP-binding protein 1035877 yhbG 3192168 yhbG Francisella tularensis subsp. tularensis SCHU S4 ABC transporter ATP-binding protein YP_170009.1 1035146 R 177416 CDS YP_170010.1 56708114 3192048 complement(1035951..1036784) 1 NC_006570.2 ORF ftt1025c; hypothetical protein 1036784 3192048 FTT_1025c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170010.1 1035951 R 177416 CDS YP_170011.1 56708115 3192049 complement(1036771..1037397) 1 NC_006570.2 ORF ftt1026c; hypothetical protein 1037397 3192049 FTT_1026c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170011.1 1036771 R 177416 CDS YP_170012.1 56708116 3192403 complement(1037405..1037953) 1 NC_006570.2 Similar to AAP18518 Hypothetical protein yrbI from Escherichia coli (188 aa). FASTA: initn: 454 init1: 247 opt: 453 Z-score: 558.6 bits: 110.0 E(): 3.2e-23 Smith-Waterman score: 453; 50.000 identity in 152 aa overlap.; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 1037953 yrbI 3192403 yrbI Francisella tularensis subsp. tularensis SCHU S4 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_170012.1 1037405 R 177416 CDS YP_170013.1 56708117 3191284 complement(1038044..1038565) 1 NC_006570.2 Similar to IPYR_YERPE (Q8ZB98) Inorganic pyrophosphatase from Yersinia pestis (175 aa). FASTA: opt: 762 Z-score: 1001.4 E(): 6.9e-48 Smith-Waterman score: 762; 62.209 identity in 172 aa overlap.; inorganic pyrophosphatase 1038565 ppa 3191284 ppa Francisella tularensis subsp. tularensis SCHU S4 inorganic pyrophosphatase YP_170013.1 1038044 R 177416 CDS YP_170014.1 56708118 3191499 1038722..1040056 1 NC_006570.2 Similar to Q87VW4 D-alanyl-D-alanine carboxypeptidase from Pseudomonas syringae (pv. tomato) (386 aa). FASTA: opt: 602 Z-score: 704.0 E(): 2.5e-31 Smith-Waterman score: 794; 36.409 identity in 401 aa overlap.; D-alanyl-D-alanine carboxypeptidase 1040056 dacD 3191499 dacD Francisella tularensis subsp. tularensis SCHU S4 D-alanyl-D-alanine carboxypeptidase YP_170014.1 1038722 D 177416 CDS YP_170015.1 56708119 3192047 1040089..1040373 1 NC_006570.2 Similar to YE87_NITEU (Q82UJ7) Hypothetical UPF0250 protein NE1487 from Nitrosomonas europaea (87 aa). FASTA: opt: 235 Z-score: 328.5 E(): 2.1e-10 Smith-Waterman score: 235; 36.471 identity in 85 aa overlap. ORF ftt1030; hypothetical protein 1040373 3192047 FTT_1030 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170015.1 1040089 D 177416 CDS YP_170016.1 56708120 3190841 1040383..1041003 1 NC_006570.2 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 1041003 lipB 3190841 lipB Francisella tularensis subsp. tularensis SCHU S4 lipoate-protein ligase B YP_170016.1 1040383 D 177416 CDS YP_170017.1 56708121 3191685 complement(1045072..1046334) 1 NC_006570.2 Similar to Q8UDU6 NADH dehydrogenase from Agrobacterium tumefaciens (strain C58 / ATCC 33970) (438 aa). FASTA: opt: 826 Z-score: 983.7 E(): 6.7e-47 Smith-Waterman score: 826; 32.854 identity in 417 aa overlap.; NADH dehydrogenase 1046334 ndh 3191685 ndh Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase YP_170017.1 1045072 R 177416 CDS YP_170018.1 56708122 3191979 complement(1046441..1048174) 1 NC_006570.2 Similar to P77890 LprpoD (RNA polymerase sigma factor) from Legionella pneumophila (620 aa). FASTA: opt: 1367 Z-score: 1480.9 E(): 1.4e-74 Smith-Waterman score: 1624; 47.182 identity in 621 aa overlap.; RNA polymerase sigma-70 factor 1048174 rpoD 3191979 rpoD Francisella tularensis subsp. tularensis SCHU S4 RNA polymerase sigma-70 factor YP_170018.1 1046441 R 177416 CDS YP_170019.1 56708123 3191526 complement(1048194..1050011) 1 NC_006570.2 Similar to Q8DEG2 DNA primase from Vibrio vulnificus (587 aa). FASTA: opt: 1152 Z-score: 1324.3 E(): 7.2e-66 Smith-Waterman score: 1155; 39.679 identity in 499 aa overlap.; DNA primase 1050011 dnaG 3191526 dnaG Francisella tularensis subsp. tularensis SCHU S4 DNA primase YP_170019.1 1048194 R 177416 CDS YP_170020.1 56708124 3192045 complement(1050032..1050478) 1 NC_006570.2 Similar to Q87SL6 Conserved hypothetical protein from Vibrio parahaemolyticus (147 aa). FASTA: opt: 473 Z-score: 548.0 E(): 1.2e-22 Smith-Waterman score: 473; 47.586 identity in 145 aa overlap. ORF ftt1037c; hypothetical protein 1050478 3192045 FTT_1037c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170020.1 1050032 R 177416 CDS YP_170021.1 56708125 3191008 complement(1050539..1050736) 1 NC_006570.2 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1050736 rpsU 3191008 rpsU Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S21 YP_170021.1 1050539 R 177416 CDS YP_170022.1 56708126 3191495 1050992..1052395 1 NC_006570.2 Similar to Q83FD1 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase from Coxiella burnetii (477 aa). FASTA: opt: 654 Z-score: 780.3 E(): 1.4e-35 Smith-Waterman score: 654; 29.436 identity in 479 aa overlap.; D-alanyl-D-alanine carboxypeptidase 1052395 dacB1 3191495 dacB1 Francisella tularensis subsp. tularensis SCHU S4 D-alanyl-D-alanine carboxypeptidase YP_170022.1 1050992 D 177416 CDS YP_170023.1 56708127 3192043 1052396..1053007 1 NC_006570.2 Similar to Q8EBG1 Conserved hypothetical protein from Shewanella oneidensis (205 aa). FASTA: opt: 610 Z-score: 776.5 E(): 2.3e-35 Smith-Waterman score: 610; 45.810 identity in 179 aa overlap. ORF ftt1040; lipoprotein 1053007 3192043 FTT_1040 Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_170023.1 1052396 D 177416 CDS YP_170024.1 56708128 3192044 1053023..1053439 1 NC_006570.2 Similar to Q8ESG1 Hypothetical conserved protein from Oceanobacillus iheyensis (134 aa). FASTA: opt: 215 Z-score: 303.3 E(): 5.3e-09 Smith-Waterman score: 215; 32.773 identity in 119 aa overlap. ORF ftt1041; hypothetical protein 1053439 3192044 FTT_1041 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170024.1 1053023 D 177416 CDS YP_170025.1 56708129 3192041 1053432..1054235 1 NC_006570.2 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1054235 3192041 FTT_1042 Francisella tularensis subsp. tularensis SCHU S4 C32 tRNA thiolase YP_170025.1 1053432 D 177416 CDS YP_170026.1 56708130 3192042 1054249..1055061 1 NC_006570.2 Similar to O32766 Macrophage infectivity potentiator from Legionella hackeliae (249 aa). FASTA: opt: 235 Z-score: 273.3 E(): 2.5e-07 Smith-Waterman score: 343; 27.599 identity in 279 aa overlap. ORF ftt1043; FKBP-type peptidylprolyl isomerase 1055061 3192042 FTT_1043 Francisella tularensis subsp. tularensis SCHU S4 FKBP-type peptidylprolyl isomerase YP_170026.1 1054249 D 177416 CDS YP_170027.1 56708131 3190799 complement(1055079..1056056) 1 NC_006570.2 Similar to Q8EB79 Octaprenyl-diphosphate synthase from Shewanella oneidensis (323 aa). FASTA: opt: 1117 Z-score: 1360.2 E(): 7.1e-68 Smith-Waterman score: 1117; 53.704 identity in 324 aa overlap.; octaprenyl-diphosphate synthase 1056056 ispB 3190799 ispB Francisella tularensis subsp. tularensis SCHU S4 octaprenyl-diphosphate synthase YP_170027.1 1055079 R 177416 CDS YP_170028.1 56708132 3192040 complement(1056146..1056577) 1 NC_006570.2 ORF ftt1045c; hypothetical protein 1056577 3192040 FTT_1045c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170028.1 1056146 R 177416 CDS YP_170029.1 56708133 3192039 complement(1056658..1057281) 1 NC_006570.2 ORF ftt1046c; hypothetical protein 1057281 3192039 FTT_1046c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170029.1 1056658 R 177416 CDS YP_170030.2 255961458 3192038 complement(1057953..1058315) 1 NC_006570.2 ORF ftt1047c; hypothetical protein 1058315 3192038 FTT_1047c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170030.2 1057953 R 177416 CDS YP_170031.2 255961459 3192037 complement(1058367..1058933) 1 NC_006570.2 ORF ftt1048c; hypothetical protein 1058933 3192037 FTT_1048c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170031.2 1058367 R 177416 CDS YP_170032.1 56708136 3191498 complement(1059979..1061391) 1 NC_006570.2 Similar to CYSN_VIBPA (Q87SX9) Sulfate adenylyltransferase subunit 1 from Vibrio parahaemolyticus (476 aa). FASTA: opt: 1823 Z-score: 2170.8 E(): 5e-113 Smith-Waterman score: 1823; 59.488 identity in 469 aa overlap.; sulfate adenylyltransferase 1061391 cysN 3191498 cysN Francisella tularensis subsp. tularensis SCHU S4 sulfate adenylyltransferase YP_170032.1 1059979 R 177416 CDS YP_170033.1 56708137 3192036 complement(1061830..1061994) 1 NC_006570.2 ORF ftt1051c; hypothetical protein 1061994 3192036 FTT_1051c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170033.1 1061830 R 177416 CDS YP_170034.1 56708138 3192035 complement(1062454..1062660) 1 NC_006570.2 ORF ftt1052c; hypothetical protein 1062660 3192035 FTT_1052c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170034.1 1062454 R 177416 CDS YP_170035.1 56708139 3191621 complement(1064388..1064876) 1 NC_006570.2 Similar to RIMI_ECOLI (P09453) Ribosomal-protein-alanine acetyltransferase (148 aa). FASTA: opt: 237 Z-score: 305.5 E(): 4e-09 Smith-Waterman score: 237; 36.585 identity in 123 aa overlap.; ribosomal-protein-alanine acetyltransferase 1064876 rimI 3191621 rimI Francisella tularensis subsp. tularensis SCHU S4 ribosomal-protein-alanine acetyltransferase YP_170035.1 1064388 R 177416 CDS YP_170036.1 56708140 3192031 complement(1064854..1065279) 1 NC_006570.2 ORF ftt1055c; hypothetical protein 1065279 3192031 FTT_1055c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170036.1 1064854 R 177416 CDS YP_170037.1 56708141 3191617 complement(1065279..1066094) 1 NC_006570.2 Similar to Q8ZEG0 Ribosomal large subunit pseudouridine synthase B from Yersinia pestis (318 aa). FASTA: opt: 938 Z-score: 1164.9 E(): 5.4e-57 Smith-Waterman score: 938; 56.705identity in 261 aa overlap.; ribosomal large subunit pseudouridine synthase B 1066094 rluB 3191617 rluB Francisella tularensis subsp. tularensis SCHU S4 ribosomal large subunit pseudouridine synthase B YP_170037.1 1065279 R 177416 CDS YP_170038.1 56708142 3192032 complement(1066087..1066992) 1 NC_006570.2 Similar to Q9KRM4 Fimbrial biogenesis and twitching motility protein, from Vibrio cholerae (237 aa). FASTA: opt: 249 Z-score: 293.4 E(): 1.9e-08 Smith-Waterman score: 249; 25.346 identity in 217 aa overlap. Tetratrico peptide repeat (TPR) containing protein. Shows a weak similarity to the lipoprotein pilF (Pseudomonas) that has an N-terminal type II (lipoprotein) signal sequence, followed by six tandem degenerated 34-amino acid repeats, which are involved in protein-protein interactions. ORF ftt1057c; Type IV pili lipoprotein 1066992 3192032 FTT_1057c Francisella tularensis subsp. tularensis SCHU S4 Type IV pili lipoprotein YP_170038.1 1066087 R 177416 CDS YP_170039.1 56708143 3192030 complement(1066982..1068094) 1 NC_006570.2 Similar to Y2A6_PSEAE (Q51385) Hypothetical protein PA3806 from Pseudomonas aeruginosa (379 aa). FASTA: opt: 1458 Z-score: 1752.5 E(): 1e-89 Smith-Waterman score: 1458; 60.434 identity in 369 aa overlap. ORF ftt1058c; radical SAM superfamily protein 1068094 3192030 FTT_1058c Francisella tularensis subsp. tularensis SCHU S4 radical SAM superfamily protein YP_170039.1 1066982 R 177416 CDS YP_170040.1 56708144 3191525 complement(1068125..1069522) 1 NC_006570.2 Similar to DNAB_PASMU (Q9CNL6) Replicative DNA helicase from Pasteurella multocida (467 aa). FASTA: opt: 1484 Z-score: 1719.2 E(): 7.2e-88 Smith-Waterman score: 1484; 51.016 identity in 443 aa overlap.; replicative DNA helicase 1069522 dnaB 3191525 dnaB Francisella tularensis subsp. tularensis SCHU S4 replicative DNA helicase YP_170040.1 1068125 R 177416 CDS YP_170041.1 56708145 3192016 complement(1069610..1070065) 1 NC_006570.2 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 1070065 rplI 3192016 rplI Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L9 YP_170041.1 1069610 R 177416 CDS YP_170042.1 56708146 3192527 complement(1070084..1070302) 1 NC_006570.2 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 1070302 rpsR 3192527 rpsR Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S18 YP_170042.1 1070084 R 177416 CDS YP_170043.1 56708147 3191971 complement(1070318..1070653) 1 NC_006570.2 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 1070653 rpsF 3191971 rpsF Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S6 YP_170043.1 1070318 R 177416 CDS YP_170044.1 56708148 3192419 1071331..1072257 1 NC_006570.2 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 1072257 hemF 3192419 hemF Francisella tularensis subsp. tularensis SCHU S4 coproporphyrinogen III oxidase YP_170044.1 1071331 D 177416 CDS YP_170046.1 56708150 3192478 complement(join(1073411..1073869,1073869..1074195)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1074195 isftu1 3192478 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170046.1 1073411 R 177416 CDS YP_170047.1 56708151 3191073 complement(1074364..1074738) 1 NC_006570.2 ORF ftt1066c; hypothetical protein 1074738 3191073 FTT_1066c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170047.1 1074364 R 177416 CDS YP_170048.1 56708152 3192027 complement(1078054..1078632) 1 NC_006570.2 ORF ftt1068c; hypothetical protein 1078632 3192027 FTT_1068c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170048.1 1078054 R 177416 CDS YP_170049.1 56708153 3192288 complement(1078721..1079626) 1 NC_006570.2 ORF ftt1069c; hypothetical protein 1079626 3192288 FTT_1069c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170049.1 1078721 R 177416 CDS YP_170050.1 56708154 3190794 complement(1082895..1083401) 1 NC_006570.2 Similar to Q82XK5 antirestriction protein from Nitrosomonas europaea (171 aa). FASTA: opt: 426 Z-score: 519.1 E(): 5e-21 Smith-Waterman score: 426; 42.771 identity in 166 aa overlap. ORF ftt1071c; hypothetical protein 1083401 3190794 FTT_1071c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170050.1 1082895 R 177416 CDS YP_170051.1 56708155 3191071 1084045..1084674 1 NC_006570.2 ORF ftt1072; hypothetical protein 1084674 3191071 FTT_1072 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170051.1 1084045 D 177416 CDS YP_170053.1 56708157 3190915 join(1085435..1085761,1085761..1086219) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1086219 isftu1 3190915 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170053.1 1085435 D 177416 CDS YP_170054.1 56708158 3191962 1087103..1087330 1 NC_006570.2 Similar to Y4MF_RHISN (P55565) Hypothetical transcriptional regulator y4mF from Rhizobium sp. (strain NGR234) (76 aa). FASTA: opt: 205 Z-score: 292.4 E(): 2.1e-08 Smith-Waterman score: 205; 47.059identity in 68 aa overlap. ORF ftt1075; transcriptional regulator 1087330 3191962 FTT_1075 Francisella tularensis subsp. tularensis SCHU S4 transcriptional regulator YP_170054.1 1087103 D 177416 CDS YP_170055.1 56708159 3192429 1087315..1088589 1 NC_006570.2 Similar to Q82V03 Possible HipA protein from Nitrosomonas europaea (429 aa). FASTA: opt: 1021 Z-score: 1249.8 E(): 1e-61 Smith-Waterman score: 1021; 41.162 identity in 413 aa overlap.; transcriptional regulator 1088589 hipA 3192429 hipA Francisella tularensis subsp. tularensis SCHU S4 transcriptional regulator YP_170055.1 1087315 D 177416 CDS YP_170058.1 56708162 3191961 complement(1089907..1090167) 1 NC_006570.2 ORF ftt1079c; hypothetical protein 1090167 3191961 FTT_1079c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170058.1 1089907 R 177416 CDS YP_170059.1 56708163 3191959 complement(1090184..1091062) 1 NC_006570.2 ORF ftt1080c; hypothetical protein 1091062 3191959 FTT_1080c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170059.1 1090184 R 177416 CDS YP_170060.1 56708164 3191958 complement(1091062..1091865) 1 NC_006570.2 ORF ftt1081c; hypothetical protein 1091865 3191958 FTT_1081c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170060.1 1091062 R 177416 CDS YP_170061.1 56708165 3191956 1092091..1092513 1 NC_006570.2 ORF ftt1082; hypothetical protein 1092513 3191956 FTT_1082 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170061.1 1092091 D 177416 CDS YP_170062.1 56708166 3191955 complement(1092529..1092786) 1 NC_006570.2 ORF ftt1083c; hypothetical protein 1092786 3191955 FTT_1083c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170062.1 1092529 R 177416 CDS YP_170063.1 56708167 3191644 complement(1092791..1093651) 1 NC_006570.2 Required for efficient pilin antigenic variation; recombination associated protein 1093651 rdgC 3191644 rdgC Francisella tularensis subsp. tularensis SCHU S4 recombination associated protein YP_170063.1 1092791 R 177416 CDS YP_170064.1 56708168 3191952 1093833..1094831 1 NC_006570.2 Similar to YM90_SHEON (Q8EES8) Hypothetical UPF0176 protein SO229 from Shewanella oneidensis (333 aa). FASTA: initn: 1561 init1: 1472 opt: 1479 Z-score: 1729.8 E(): 1.9e-88 Smith-Waterman score: 1479; 63.636identity in 330 aa overlap. ORF ftt1085; hypothetical protein 1094831 3191952 FTT_1085 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170064.1 1093833 D 177416 CDS YP_170065.1 56708169 3191953 complement(1094962..1095792) 1 NC_006570.2 Similar to Q8EFU7 Conserved hypothetical protein from Shewanella oneidensis (279 aa). FASTA: 351 opt: 789 Z-score: 963.7 E(): 8.8e-46 Smith-Waterman score: 789; 45.290 identity in 276 aa overlap. ORF ftt1086c; hypothetical protein 1095792 3191953 FTT_1086c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170065.1 1094962 R 177416 CDS YP_170066.1 56708170 3191631 complement(1095848..1097863) 1 NC_006570.2 Similar to REP_HAEIN (P44804) ATP-dependent DNA helicase rep from Haemophilus influenzae (670 aa). FASTA: opt: 2055 Z-score: 2350.5 E(): 5e-123 Smith-Waterman score: 2055; 47.806 identity in 661 aa overlap.; ATP-dependent DNA helicase 1097863 rep 3191631 rep Francisella tularensis subsp. tularensis SCHU S4 ATP-dependent DNA helicase YP_170066.1 1095848 R 177416 CDS YP_170067.1 56708171 3191950 complement(1097857..1098603) 1 NC_006570.2 ORF ftt1088c; hypothetical protein 1098603 3191950 FTT_1088c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170067.1 1097857 R 177416 CDS YP_170068.1 56708172 3191951 1099211..1099732 1 NC_006570.2 Similar to Q8EW31 Hypothetical protein from Mycoplasma penetrans (194 aa). FASTA: opt: 235 Z-score: 294.7 E(): 1.6e-08 Smith-Waterman score: 235; 31.515 identity in 165 aa overlap. ORF ftt1089; isochorismatase hydrolase family protein 1099732 3191951 FTT_1089 Francisella tularensis subsp. tularensis SCHU S4 isochorismatase hydrolase family protein YP_170068.1 1099211 D 177416 CDS YP_170069.1 56708173 3191265 1099729..1100406 1 NC_006570.2 Similar to Q8A546 membrane transporter involved in nicotinamide mononucleotide transport from Bacteroides thetaiotaomicron (188 aa). FASTA: opt: 285 Z-score: 336.8 E(): 7.2e-11 Smith-Waterman score: 302; 29.592 identity in 196 aa overlap. ORF ftt1090; hypothetical protein 1100406 3191265 FTT_1090 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170069.1 1099729 D 177416 CDS YP_170070.1 56708174 3191070 1100419..1100907 1 NC_006570.2 Similar to Q9AD62 hydrolase (193 aa). FASTA: opt: 251 Z-score: 311.7 E(): 1.8e-09 Smith-Waterman score: 251; 32.075identity in 159 aa overlap. ORF ftt1091; isochorismatase hydrolase family protein 1100907 3191070 FTT_1091 Francisella tularensis subsp. tularensis SCHU S4 isochorismatase hydrolase family protein YP_170070.1 1100419 D 177416 CDS YP_170072.1 56708176 3190749 complement(1101545..1102510) 1 NC_006570.2 Similar to Q8EBH2 Transaldolase from Shewanella oneidensis (318 aa). FASTA: opt: 1030 Z-score: 1249.3 E(): 1.1e-61 Smith-Waterman score: 1030; 50.938 identity in 320 aa overlap.; transaldolase B 1102510 talA 3190749 talA Francisella tularensis subsp. tularensis SCHU S4 transaldolase B YP_170072.1 1101545 R 177416 CDS YP_170073.1 56708177 3191261 complement(1102644..1104059) 1 NC_006570.2 Similar to Q83DX0 Cytosol aminopeptidase family protein from Coxiella burnetii (458 aa). FASTA: opt: 1273 Z-score: 1536.1 E(): 1.1e-77 Smith-Waterman score: 1273; 41.830 identity in 459 aa overlap. ORF ftt1094c; cytosol aminopeptidase 1104059 3191261 FTT_1094c Francisella tularensis subsp. tularensis SCHU S4 cytosol aminopeptidase YP_170073.1 1102644 R 177416 CDS YP_170074.1 56708178 3191260 complement(1104026..1105408) 1 NC_006570.2 Similar to Q88DA4 Outer membrane efflux protein from Pseudomonas putida (strain KT2440) (477 aa). FASTA: opt: 405 Z-score: 484.1 E(): 4.5e-19 Smith-Waterman score: 405; 22.907 identity in 454 aa overlap. Not a membrane protein. ORF ftt1095c; hypothetical protein 1105408 3191260 FTT_1095c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170074.1 1104026 R 177416 CDS YP_170075.1 56708179 3192392 complement(1105416..1108013) 1 NC_006570.2 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1108013 alaS 3192392 alaS Francisella tularensis subsp. tularensis SCHU S4 alanyl-tRNA synthetase YP_170075.1 1105416 R 177416 CDS YP_170076.1 56708180 3191259 1108169..1108615 1 NC_006570.2 ORF ftt1097; hypothetical protein 1108615 3191259 FTT_1097 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170076.1 1108169 D 177416 CDS YP_170077.1 56708181 3191257 complement(1110704..1111039) 1 NC_006570.2 ORF ftt1099c; hypothetical protein 1111039 3191257 FTT_1099c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170077.1 1110704 R 177416 CDS YP_170078.1 56708182 3191255 1111142..1111477 1 NC_006570.2 Similar to Q83DY7 Iojap-related protein from Coxiella burnetii (116 aa). FASTA: opt: 326 Z-score: 425.2 E(): 8.6e-16 Smith-Waterman score: 326; 41.509 identity in 106 aa overlap. ORF ftt1100; hypothetical protein 1111477 3191255 FTT_1100 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170078.1 1111142 D 177416 CDS YP_170079.1 56708183 3191250 1112962..1114059 1 NC_006570.2 Similar to Q8Z9P6 exported protein from Salmonella typhi (281 aa). FASTA: opt: 392 Z-score: 435.6 E(): 2.3e-16 Smith-Waterman score: 392; 33.491 identity in 212 aa overlap. ORF ftt1103; lipoprotein 1114059 3191250 FTT_1103 Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_170079.1 1112962 D 177416 CDS YP_170080.1 56708184 3191668 complement(1115543..1116397) 1 NC_006570.2 this fusion consists of methionine sulfoxide B reductase at the N-terminus and A at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion protein of these enzymes with thioredoxin provides protection against oxidative stress in Neisseria gonorrhoeae; bifunctional methionine sulfoxide reductase B/A protein 1116397 msrA1 3191668 msrA1 Francisella tularensis subsp. tularensis SCHU S4 bifunctional methionine sulfoxide reductase B/A protein YP_170080.1 1115543 R 177416 CDS YP_170081.1 56708185 3191010 1116526..1117002 1 NC_006570.2 Similar to Q8TID9 Benzodiazepine receptor TspO from Methanosarcina acetivorans (160 aa). FASTA: opt: 417 Z-score: 464.9 E(): 5.3e-18 Smith-Waterman score: 417; 40.994 identity in 161 aa overlap.; tryptophan-rich sensory protein 1117002 tspO 3191010 tspO Francisella tularensis subsp. tularensis SCHU S4 tryptophan-rich sensory protein YP_170081.1 1116526 D 177416 CDS YP_170082.1 56708186 3191249 1119088..1119840 1 NC_006570.2 Similar to Q891T6 23S rRNA methyltransferase (EC 2.1.1.-) from Clostridium tetani (260 aa). FASTA: opt: 442 Z-score: 545.7 E(): 1.7e-22 Smith-Waterman score: 442; 34.091 identity in 264 aa overlap. ORF ftt1108; rRNA methyltransferase 1119840 3191249 FTT_1108 Francisella tularensis subsp. tularensis SCHU S4 rRNA methyltransferase YP_170082.1 1119088 D 177416 CDS YP_170083.1 56708187 3191246 1119934..1120902 1 NC_006570.2 Similar to Q8U768 Choloylglycine hydrolase family protein from Agrobacterium tumefaciens (strain C58 / ATCC 33970) (355 aa). FASTA: opt: 362 Z-score: 436.7 E(): 2e-16 Smith-Waterman score: 424; 28.956 identity in 297 aa overlap. ORF ftt1109; choloylglycine hydrolase family protein 1120902 3191246 FTT_1109 Francisella tularensis subsp. tularensis SCHU S4 choloylglycine hydrolase family protein YP_170083.1 1119934 D 177416 CDS YP_170084.1 56708188 3191247 1121067..1121420 1 NC_006570.2 ORF ftt1110; hypothetical protein 1121420 3191247 FTT_1110 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170084.1 1121067 D 177416 CDS YP_170085.1 56708189 3190832 1121516..1122259 1 NC_006570.2 ISFtu2. Transposase, member of the IS5 family. Identical to Q8GM03 transposase from Francisella tularensis (247 aa).; transposase 1122259 isftu2 3190832 isftu2 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170085.1 1121516 D 177416 CDS YP_170086.1 56708190 3191978 complement(1122307..1123185) 1 NC_006570.2 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 1123185 rpoH 3191978 rpoH Francisella tularensis subsp. tularensis SCHU S4 RNA polymerase factor sigma-32 YP_170086.1 1122307 R 177416 CDS YP_170087.1 56708191 3191244 complement(1123209..1123739) 1 NC_006570.2 ORF ftt1113c; hypothetical protein 1123739 3191244 FTT_1113c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170087.1 1123209 R 177416 CDS YP_170088.1 56708192 3191076 complement(1123771..1124715) 1 NC_006570.2 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 1124715 secF 3191076 secF Francisella tularensis subsp. tularensis SCHU S4 preprotein translocase subunit SecF YP_170088.1 1123771 R 177416 CDS YP_170089.1 56708193 3191719 complement(1124734..1126671) 1 NC_006570.2 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 1126671 secD 3191719 secD Francisella tularensis subsp. tularensis SCHU S4 preprotein translocase subunit SecD YP_170089.1 1124734 R 177416 CDS YP_170090.1 56708194 3192124 complement(1126728..1127084) 1 NC_006570.2 Similar to Q8XFR4 (Q8XFR4) membrane protein (Preprotein translocase IISP family, membrane subunit) from Salmonella typhi (110 aa). FASTA: opt: 347 Z-score: 458.8 E(): 1.2e-17 Smith-Waterman score: 347; 47.664 identity in 107 aa overlap.; preprotein translocase family protein 1127084 yajC 3192124 yajC Francisella tularensis subsp. tularensis SCHU S4 preprotein translocase family protein YP_170090.1 1126728 R 177416 CDS YP_170091.1 56708195 3191243 complement(1127638..1128210) 1 NC_006570.2 Similar to Q9HZE2 Hypothetical protein PA3066 from Pseudomonas aeruginosa (190 aa). FASTA: opt: 359 Z-score: 477.3 E(): 1.1e-18 Smith-Waterman score: 359; 35.638 identity in 188 aa overlap. ORF ftt1117c; isochorismatase hydrolase family protein 1128210 3191243 FTT_1117c Francisella tularensis subsp. tularensis SCHU S4 isochorismatase hydrolase family protein YP_170091.1 1127638 R 177416 CDS YP_170092.1 56708196 3191233 complement(1128222..1129097) 1 NC_006570.2 Similar to Q9KKY7 Hypothetical protein VCA0963 from Vibrio cholerae (307 aa). FASTA: opt: 340 Z-score: 385.2 E(): 1.5e-13 Smith-Waterman score: 340; 22.603 identity in 292 aa overlap. ORF ftt1118c; hypothetical protein 1129097 3191233 FTT_1118c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170092.1 1128222 R 177416 CDS YP_170093.1 56708197 3191673 1129202..1130077 1 NC_006570.2 Similar to Q8D460 Transcriptional regulator from Vibrio vulnificus (296 aa). FASTA: opt: 459 Z-score: 575.9 E(): 3.5e-24 Smith-Waterman score: 459; 29.197 identity in 274 aa overlap. ORF ftt1119; LysR family transcriptional regulator 1130077 3191673 FTT_1119 Francisella tularensis subsp. tularensis SCHU S4 LysR family transcriptional regulator YP_170093.1 1129202 D 177416 CDS YP_170094.1 56708198 3190761 complement(1130084..1131187) 1 NC_006570.2 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 1131187 tgt 3190761 tgt Francisella tularensis subsp. tularensis SCHU S4 queuine tRNA-ribosyltransferase YP_170094.1 1130084 R 177416 CDS YP_170095.1 56708199 3191672 complement(1132161..1132631) 1 NC_006570.2 ORF ftt1122c; lipoprotein 1132631 3191672 FTT_1122c Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_170095.1 1132161 R 177416 CDS YP_170096.1 56708200 3191266 1133213..1133827 1 NC_006570.2 Similar to Y647_YERPE (Q8ZI67) Hypothetical UPF0078 protein YPO0647/Y3532 (216 aa). FASTA: opt: 604 Z-score: 713.6 E(): 7.4e-32 Smith-Waterman score: 604; 48.500 identity in 200 aa overlap.; hypothetical protein 1133827 ygiH 3191266 ygiH Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170096.1 1133213 D 177416 CDS YP_170097.1 56708201 3190821 1133790..1134866 1 NC_006570.2 Similar to AAP15732 ATP-binding component of a transporter from Shigella flexneri (343 aa). FASTA: opt: 1070 Z-score: 1232.1 E(): 9.7e-61 Smith-Waterman score: 1070; 46.221 identity in 344 aa overlap.; D-methionine ABC transporter ATP-binding protein 1134866 metN 3190821 metN Francisella tularensis subsp. tularensis SCHU S4 D-methionine ABC transporter ATP-binding protein YP_170097.1 1133790 D 177416 CDS YP_170098.1 56708202 3190931 1134844..1136316 1 NC_006570.2 Similar to METQ_SALTI (Q8Z992) D-methionine-binding lipoprotein metQ [Precursor] from Salmonella typhi (271 aa). FASTA: opt: 815 Z-score: 926.6 E(): 1e-43 Smith-Waterman score: 815; 51.020identity in 245 aa overlap. The FASTA-hits do not include the first 220 aa. Probably two genes, metI and metQ, in other organisms.; D-methionine ABC transporter permease/substrate-binding protein 1136316 metIQ 3190931 metIQ Francisella tularensis subsp. tularensis SCHU S4 D-methionine ABC transporter permease/substrate-binding protein YP_170098.1 1134844 D 177416 CDS YP_170099.1 56708203 3191671 1136387..1137598 1 NC_006570.2 Similar to Q83BG9 Tryptophan/tyrosine permease family protein from Coxiella burnetii (426 aa). FASTA: opt: 560 Z-score: 604.8 E(): 8.5e-26 Smith-Waterman score: 560; 27.750identity in 400 aa overlap. ORF ftt1126; aromatic amino acid HAAP transporter 1137598 3191671 FTT_1126 Francisella tularensis subsp. tularensis SCHU S4 aromatic amino acid HAAP transporter YP_170099.1 1136387 D 177416 CDS YP_170100.1 56708204 3192171 1137664..1138422 1 NC_006570.2 Similar to Q83F83 Rhodanese domain protein from Coxiella burnetii (124 aa). FASTA: opt: 447 Z-score: 559.4 E(): 2.9e-23 Smith-Waterman score: 447; 51.240 identity in 121 aa overlap. ORF ftt1127; rhodanese-like family protein 1138422 3192171 FTT_1127 Francisella tularensis subsp. tularensis SCHU S4 rhodanese-like family protein YP_170100.1 1137664 D 177416 CDS YP_170101.1 56708205 3190836 1138435..1138914 1 NC_006570.2 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 1138914 ispF 3190836 ispF Francisella tularensis subsp. tularensis SCHU S4 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_170101.1 1138435 D 177416 CDS YP_170102.1 56708206 3191730 complement(1138919..1140604) 1 NC_006570.2 Similar to CPHA_ANAVA (O86109) Cyanophycin synthetase from Anabaena variabilis (901 aa). FASTA: opt: 2470 Z-score: 2850.7 E(): 6.8e-151 Smith-Waterman score: 2506; 46.787 identity in 887 aa overlap. Probable paralog of cphA since the protein sequences show considerable divergence and gene length differ. ORF ftt1129c; hypothetical protein 1140604 3191730 FTT_1129c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170102.1 1138919 R 177416 CDS YP_170103.1 56708207 3191888 complement(1140630..1143452) 1 NC_006570.2 catalyze the formation of cyanophycin which may act to store excess nitrogen; cyanophycin synthetase 1143452 cphA 3191888 cphA Francisella tularensis subsp. tularensis SCHU S4 cyanophycin synthetase YP_170103.1 1140630 R 177416 CDS YP_008492913.1 537470116 3191441 1143576..1144319 1 NC_006570.2 molybdopterin-binding protein 1144319 3191441 FTT_1131 Francisella tularensis subsp. tularensis SCHU S4 molybdopterin-binding protein YP_008492913.1 1143576 D 177416 CDS YP_170104.1 56708208 3190955 complement(1144308..1145060) 1 NC_006570.2 Similar to Q83DQ4 Glycerophosphoryl diester phosphodiesterase, (250 aa). FASTA: opt: 306 Z-score: 366.0 E(): 1.7e-12 Smith-Waterman score: 306; 28.916identity in 249 aa overlap.; glycerophosphoryl diester phosphodiesterase 1145060 glpQ 3190955 glpQ Francisella tularensis subsp. tularensis SCHU S4 glycerophosphoryl diester phosphodiesterase YP_170104.1 1144308 R 177416 CDS YP_170105.1 56708209 3191922 1145219..1146997 1 NC_006570.2 Similar to O68431 Pilus assembly protein PilB from Pseudomonas syringae (pv. tomato) (575 aa). FASTA: opt: 1381 Z-score: 1521.6 E(): 7.3e-77 Smith-Waterman score: 1592; 44.597 identity in 583 aa overlap. PilB is required for pili assembly. Homologous to pilT but which has the opposite effect. Homologs exists in other systems.; Type IV pili ABC transporter ATP-binding protein 1146997 pilB 3191922 pilB Francisella tularensis subsp. tularensis SCHU S4 Type IV pili ABC transporter ATP-binding protein YP_170105.1 1145219 D 177416 CDS YP_170106.1 56708210 3192189 1147012..1148241 1 NC_006570.2 Similar to Q888U1 Type IV pilus biogenesis protein PilC from Pseudomonas syringae (pv. tomato) (405 aa). FASTA: opt: 1017 Z-score: 1153.2 E(): 2.4e-56 Smith-Waterman score: 1017; 39.055identity in 402 aa overlap. Termed pilF in N. gonorrhoeae.; Type IV pili polytopic inner membrane protein 1148241 pilC 3192189 pilC Francisella tularensis subsp. tularensis SCHU S4 Type IV pili polytopic inner membrane protein YP_170106.1 1147012 D 177416 CDS YP_170107.1 56708211 3191658 complement(1149485..1149820) 1 NC_006570.2 ORF ftt1136c; hypothetical protein 1149820 3191658 FTT_1136c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170107.1 1149485 R 177416 CDS YP_170108.1 56708212 3191825 complement(1149837..1150097) 1 NC_006570.2 ORF ftt1137c; hypothetical protein 1150097 3191825 FTT_1137c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170108.1 1149837 R 177416 CDS YP_170109.1 56708213 3192420 1150231..1151232 1 NC_006570.2 Similar to HEMZ_RHIME (Q92M52) Ferrochelatase (EC 4.99.1.1) from Rhizobium meliloti (Sinorhizobium meliloti) (339 aa). FASTA: opt: 1069 Z-score: 1243.4 E(): 2.3e-61 Smith-Waterman score: 1069; 48.160 identity in 326 aa overlap.; ferrochelatase 1151232 hemH 3192420 hemH Francisella tularensis subsp. tularensis SCHU S4 ferrochelatase YP_170109.1 1150231 D 177416 CDS YP_170110.1 56708214 3191969 1153449..1153646 1 NC_006570.2 ORF ftt1140; hypothetical protein 1153646 3191969 FTT_1140 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170110.1 1153449 D 177416 CDS YP_170111.1 56708215 3191798 complement(join(1153900..1154358,1154358..1154684)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1154684 isftu1 3191798 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170111.1 1153900 R 177416 CDS YP_170112.1 56708216 3191981 1155021..1155266 1 NC_006570.2 ORF ftt1143; hypothetical protein 1155266 3191981 FTT_1143 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170112.1 1155021 D 177416 CDS YP_170113.1 56708217 3192345 1156322..1156528 1 NC_006570.2 Similar to Q8XGJ2 Cation transport regulator ChaB from Salmonella typhi (76 aa). FASTA: opt: 267 Z-score: 394.9 E(): 4.2e-14 Smith-Waterman score: 267; 54.412 identity in 68 aa overlap.; cation transport regulator 1156528 chaB 3192345 chaB Francisella tularensis subsp. tularensis SCHU S4 cation transport regulator YP_170113.1 1156322 D 177416 CDS YP_170114.1 56708218 3191519 complement(1157636..1158811) 1 NC_006570.2 Similar to DFP_HAEIN (P44953) DNA/pantothenate metabolism flavoprotein homolog from Haemophilus influenzae (400 aa). FASTA: opt: 1012 Z-score: 1206.6 E(): 2.6e-59 Smith-Waterman score: 1012; 43.577identity in 397 aa overlap.; 4'-phosphopantothenoylcysteine decarboxylase 1158811 dfp 3191519 dfp Francisella tularensis subsp. tularensis SCHU S4 4'-phosphopantothenoylcysteine decarboxylase YP_170114.1 1157636 R 177416 CDS YP_170115.1 56708219 3192394 complement(1158824..1160008) 1 NC_006570.2 Similar to YJHB_ECOLI (P39352) Hypothetical metabolite transport protein yjhB from Escherichia coli (405 aa). FASTA: opt: 383 Z-score: 393.4 E(): 5.1e-14 Smith-Waterman score: 383; 26.425 identity in 386 aa overlap.; major facilitator transporter 1160008 yjhB 3192394 yjhB Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_170115.1 1158824 R 177416 CDS YP_170116.1 56708220 3191748 complement(1160084..1161592) 1 NC_006570.2 Similar to Q8XT33 Probable amino-acid permease transmembrane from Ralstonia solanacearum (Pseudomonas solanacearum) (543 aa). FASTA: opt: 960 Z-score: 1077.6 E(): 3.9e-52 Smith-Waterman score: 969; 35.730 identity in 445 aa overlap. ORF ftt1149c; amino acid transporter family protein 1161592 3191748 FTT_1149c Francisella tularensis subsp. tularensis SCHU S4 amino acid transporter family protein YP_170116.1 1160084 R 177416 CDS YP_170117.1 56708221 3191660 complement(1161752..1165825) 1 NC_006570.2 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 1165825 putA 3191660 putA Francisella tularensis subsp. tularensis SCHU S4 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_170117.1 1161752 R 177416 CDS YP_170118.1 56708222 3191681 complement(1165833..1166120) 1 NC_006570.2 Similar to Q87LM9 Conserved hypothetical protein from Vibrio parahaemolyticus (86 aa). FASTA: opt: 176 Z-score: 242.1 E(): 1.4e-05 Smith-Waterman score: 176; 32.857 identity in 70 aa overlap. ORF ftt1151c; hypothetical protein 1166120 3191681 FTT_1151c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170118.1 1165833 R 177416 CDS YP_170119.1 56708223 3192179 1166334..1166717 1 NC_006570.2 ORF ftt1152; hypothetical protein 1166717 3192179 FTT_1152 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170119.1 1166334 D 177416 CDS YP_170120.1 56708224 3192176 complement(1166784..1167008) 1 NC_006570.2 ORF ftt1153c; hypothetical protein 1167008 3192176 FTT_1153c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170120.1 1166784 R 177416 CDS YP_170121.1 56708225 3190946 complement(1167066..1168145) 1 NC_006570.2 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1168145 aroB 3190946 aroB Francisella tularensis subsp. tularensis SCHU S4 3-dehydroquinate synthase YP_170121.1 1167066 R 177416 CDS YP_170122.1 56708226 3192541 complement(1168142..1168672) 1 NC_006570.2 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 1168672 aroK 3192541 aroK Francisella tularensis subsp. tularensis SCHU S4 shikimate kinase I YP_170122.1 1168142 R 177416 CDS YP_170123.1 56708227 3191514 complement(1168798..1170582) 1 NC_006570.2 Similar to Q8EK21 Type IV pilus biogenesis protein PilQ from Shewanella oneidensis (684 aa). FASTA: opt: 1014 Z-score: 1145.2 E(): 6.8e-56 Smith-Waterman score: 1014; 31.658 identity in 597 aa overlap. The nearest gene neighbours show similarity to pilN, pilO and pilP. Also required for type II protein secretion.; Type IV pilin multimeric outer membrane protein 1170582 pilQ 3191514 pilQ Francisella tularensis subsp. tularensis SCHU S4 Type IV pilin multimeric outer membrane protein YP_170123.1 1168798 R 177416 CDS YP_170124.1 56708228 3191399 complement(1170595..1171185) 1 NC_006570.2 Similar to Q8DCM3 Tfp pilus assembly protein PilP from Vibrio vulnificus (170 aa). FASTA: opt: 176 Z-score: 222.1 E(): 0.00018 Smith-Waterman score: 176; 29.921 identity in 127 aa overlap. Weak similarity to the lipoprotein pilP, which appears to be required for stabilisation of pilQ multimer formation. The nearest gene neighbours show similarity to pilN, pilO and pilQ, which indicates that this protein could be pilP ORF ftt1157c; Type IV pili lipoprotein 1171185 3191399 FTT_1157c Francisella tularensis subsp. tularensis SCHU S4 Type IV pili lipoprotein YP_170124.1 1170595 R 177416 CDS YP_170125.1 56708229 3191034 complement(1171191..1171787) 1 NC_006570.2 Similar to Q8PH76 Fimbrial assembly membrane protein from Xanthomonas axonopodis (pv. citri) (221 aa). FASTA: opt: 144 Z-score: 177.4 E(): 0.055 Smith-Waterman score: 144; 25.946 identity in 185 aa overlap. Weak similarity to type IV pili glycosylation protein (pilO). The nearest gene neighbours show similarity to pilN, pilP and pilQ, which indicates that this protein could be pilO. PilO is required for glycosylation of Pseudomonas aeruginosa pilin. ORF ftt1158c; Type IV pili glycosylation protein 1171787 3191034 FTT_1158c Francisella tularensis subsp. tularensis SCHU S4 Type IV pili glycosylation protein YP_170125.1 1171191 R 177416 CDS YP_170126.1 56708230 3191614 complement(1171781..1172344) 1 NC_006570.2 Similar to Q52540 Membrane protein PilN from Pseudomonas syringae (199 aa). FASTA: opt: 143 Z-score: 182.6 E(): 0.028 Smith-Waterman score: 143; 23.704 identity in 135 aa overlap. The nearest gene neighbours show similarity to pilO, pilP and pilQ, which indicates that this protein could be pilN. PilN is also required for type II protein secretion. ORF ftt1159c; Type IV pili associated protein 1172344 3191614 FTT_1159c Francisella tularensis subsp. tularensis SCHU S4 Type IV pili associated protein YP_170126.1 1171781 R 177416 CDS YP_170127.1 56708231 3192170 complement(1172346..1173350) 1 NC_006570.2 ORF ftt1160c; hypothetical protein 1173350 3192170 FTT_1160c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170127.1 1172346 R 177416 CDS YP_170128.1 56708232 3192396 1173477..1174133 1 NC_006570.2 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 1174133 adk 3192396 adk Francisella tularensis subsp. tularensis SCHU S4 adenylate kinase YP_170128.1 1173477 D 177416 CDS YP_170129.1 56708233 3192471 complement(1177474..1177890) 1 NC_006570.2 ORF ftt1163c; hypothetical protein 1177890 3192471 FTT_1163c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170129.1 1177474 R 177416 CDS YP_170130.1 56708234 3191858 complement(1177905..1178798) 1 NC_006570.2 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 1178798 era 3191858 era Francisella tularensis subsp. tularensis SCHU S4 GTP-binding protein Era YP_170130.1 1177905 R 177416 CDS YP_170131.1 56708235 3192538 complement(1178912..1180105) 1 NC_006570.2 Similar to Q83E19 Aspartate aminotransferase from Coxiella burnetii (394 aa). FASTA: opt: 1067 Z-score: 1292.7 E(): 4.1e-64 Smith-Waterman score: 1067; 41.645 identity in 389 aa overlap.; aspartate aminotransferase 1180105 aspC2 3192538 aspC2 Francisella tularensis subsp. tularensis SCHU S4 aspartate aminotransferase YP_170131.1 1178912 R 177416 CDS YP_170132.1 56708236 3192326 complement(1180115..1180921) 1 NC_006570.2 Similar to Q8D5X6 Predicted glutamine amidotransferase from Vibrio vulnificus (253 aa). FASTA: opt: 654 Z-score: 813.9 E(): 1.9e-37 Smith-Waterman score: 654; 42.466identity in 219 aa overlap. ORF ftt1166c; glutamine amidotransferase 1180921 3192326 FTT_1166c Francisella tularensis subsp. tularensis SCHU S4 glutamine amidotransferase YP_170132.1 1180115 R 177416 CDS YP_170133.1 56708237 3192328 complement(1180925..1181563) 1 NC_006570.2 Similar to Q8EE04 (Q8EE04) Conserved hypothetical protein from Shewanella oneidensis (236 aa). FASTA: opt: 349 Z-score: 425.3 E(): 8.5e-16 Smith-Waterman score: 359; 32.273 identity in 220 aa overlap. ORF ftt1167c; glycoprotease family protein 1181563 3192328 FTT_1167c Francisella tularensis subsp. tularensis SCHU S4 glycoprotease family protein YP_170133.1 1180925 R 177416 CDS YP_170134.1 56708238 3192442 complement(1181567..1182700) 1 NC_006570.2 Similar to Q99VS2 NagA protein (Probable N-acetylglucosamine-6-phosphate deacetylase) from Staphylococcus aureus (393 aa). FASTA: opt: 1006 Z-score: 1213.0 E(): 1.1e-59 Smith-Waterman score: 1006; 43.523 identity in 386 aa overlap.; N-acetylglucosamine-6-phosphate deacetylase 1182700 nagA 3192442 nagA Francisella tularensis subsp. tularensis SCHU S4 N-acetylglucosamine-6-phosphate deacetylase YP_170134.1 1181567 R 177416 CDS YP_170135.1 56708239 3190858 1182763..1183635 1 NC_006570.2 Similar to Q8EE00 GTP-binding protein (313 aa). FASTA: opt: 793 Z-score: 926.5 E(): 1e-43 Smith-Waterman score: 793; 44.218 identity in 294 aa overlap. ORF ftt1169; GTP-binding protein 1183635 3190858 FTT_1169 Francisella tularensis subsp. tularensis SCHU S4 GTP-binding protein YP_170135.1 1182763 D 177416 CDS YP_170136.1 56708240 3190838 1183699..1185447 1 NC_006570.2 ORF ftt1170; lipoprotein 1185447 3190838 FTT_1170 Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_170136.1 1183699 D 177416 CDS YP_170137.1 56708241 3190753 complement(1185437..1186903) 1 NC_006570.2 Similar to Q8RN13 HsdM from Campylobacter jejuni (494 aa). FASTA: opt: 2001 Z-score: 2374.3 E(): 2.3e-124 Smith-Waterman score: 2001; 59.719 identity in 499 aa overlap.; DNA-methyltransferase, type I restriction-modification enzyme subunit M 1186903 hsdM 3190753 hsdM Francisella tularensis subsp. tularensis SCHU S4 DNA-methyltransferase, type I restriction-modification enzyme subunit M YP_170137.1 1185437 R 177416 CDS YP_170138.1 56708242 3191897 complement(1186890..1187321) 1 NC_006570.2 Similar to Q9HSS3 Cold shock protein from Halobacterium sp. (strain NRC-1 / ATCC 700922 / JCM 11081) (74 aa). FASTA: opt: 170 Z-score: 221.1 E(): 0.0002 Smith-Waterman score: 170; 40.323identity in 62 aa overlap. CDS is longer than FASTA matches. Homology is to first 70 aa of protein only and no matches found for 2nd half of CDS; DNA-binding cold shock protein 1187321 csp 3191897 csp Francisella tularensis subsp. tularensis SCHU S4 DNA-binding cold shock protein YP_170138.1 1186890 R 177416 CDS YP_170139.1 56708243 3192318 complement(1188833..1189042) 1 NC_006570.2 ORF ftt1174c; hypothetical protein 1189042 3192318 FTT_1174c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170139.1 1188833 R 177416 CDS YP_170140.1 56708244 3192329 complement(1189242..1189880) 1 NC_006570.2 ORF ftt1175c; hypothetical protein 1189880 3192329 FTT_1175c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170140.1 1189242 R 177416 CDS YP_170143.1 56708247 3190966 1194339..1196156 1 NC_006570.2 Similar to Q9KNJ4 GTP-binding protein TypA from Vibrio cholerae (609 aa). FASTA: opt: 2972 Z-score: 3319.9 E(): 5e-177 Smith-Waterman score: 2972; 73.045identity in 601 aa overlap.; GTP binding translational elongation factor Tu and G family protein 1196156 bipA 3190966 bipA Francisella tularensis subsp. tularensis SCHU S4 GTP binding translational elongation factor Tu and G family protein YP_170143.1 1194339 D 177416 CDS YP_170144.1 56708248 3192241 complement(1197099..1198904) 1 NC_006570.2 Similar to Q8EFL9 Gamma-glutamyltranspeptidase from Shewanella oneidensis (579 aa). FASTA: opt: 2002 Z-score: 2308.7 E(): 1.1e-120 Smith-Waterman score: 2002; 54.545 identity in 572 aa overlap.; gamma-glutamyltranspeptidase 1198904 ggt 3192241 ggt Francisella tularensis subsp. tularensis SCHU S4 gamma-glutamyltranspeptidase YP_170144.1 1197099 R 177416 CDS YP_170145.1 56708249 3191007 complement(1199956..1201161) 1 NC_006570.2 Similar to YFCK_ECO57 (Q8XCQ7) Hypothetical protein yfcK from Escherichia coli (668 aa). FASTA: opt: 495 Z-score: 572.0 E(): 5.7e-24 Smith-Waterman score: 495; 28.087 identity in 413 aa overlap. ORF ftt1183c; lipoprotein 1201161 3191007 FTT_1183c Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_170145.1 1199956 R 177416 CDS YP_170146.1 56708250 3191004 complement(1201203..1201508) 1 NC_006570.2 Similar to Y369_VIBVU (Q8DF55) Hypothetical protein VV10369 from Vibrio vulnificus (117 aa). FASTA: opt: 238 Z-score: 320.2 E(): 6.1e-10 Smith-Waterman score: 238; 41.304 identity in 92 aa overlap. ORF ftt1184c; hypothetical protein 1201508 3191004 FTT_1184c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170146.1 1201203 R 177416 CDS YP_170147.1 56708251 3191001 complement(1201508..1201939) 1 NC_006570.2 Similar to Q8ZH13 Hypothetical protein YPO1102 from Yersinia pestis (144 aa). FASTA: opt: 463 Z-score: 623.4 E(): 7.9e-27 Smith-Waterman score: 463; 43.662 39dentity in 142 aa overlap. ORF ftt1185c; hypothetical protein 1201939 3191001 FTT_1185c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170147.1 1201508 R 177416 CDS YP_170148.1 56708252 3190711 1202014..1202487 1 NC_006570.2 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 1202487 smpB 3190711 smpB Francisella tularensis subsp. tularensis SCHU S4 SsrA-binding protein YP_170148.1 1202014 D 177416 CDS YP_170149.1 56708253 3190998 1202488..1203243 1 NC_006570.2 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1203243 3190998 FTT_1187 Francisella tularensis subsp. tularensis SCHU S4 C32 tRNA thiolase YP_170149.1 1202488 D 177416 CDS YP_170150.1 56708254 3190993 1203515..1204150 1 NC_006570.2 ORF ftt1188; hypothetical protein 1204150 3190993 FTT_1188 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170150.1 1203515 D 177416 CDS YP_170151.1 56708255 3192120 complement(1205946..1207331) 1 NC_006570.2 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 1207331 xseA 3192120 xseA Francisella tularensis subsp. tularensis SCHU S4 exodeoxyribonuclease VII large subunit YP_170151.1 1205946 R 177416 CDS YP_170152.1 56708256 3190989 1207484..1208644 1 NC_006570.2 Similar to Q8RFU4 N-acyl-L-amino acid amidohydrolase from Fusobacterium nucleatum (subsp. nucleatum) (393 aa). FASTA: opt: 945 Z-score: 1170.3 E(): 2.7e-57 Smith-Waterman score: 945; 38.259 identity in 379 aa overlap. ORF ftt1191; aminoacylase 1208644 3190989 FTT_1191 Francisella tularensis subsp. tularensis SCHU S4 aminoacylase YP_170152.1 1207484 D 177416 CDS YP_170154.1 56708258 3192282 complement(1210462..1211388) 1 NC_006570.2 Similar to Q884M8 Conserved hypothetical protein from Pseudomonas syringae (pv. tomato) (319 aa). FASTA: opt: 460 Z-score: 588.5 E(): 6.9e-25 Smith-Waterman score: 460; 30.435identity in 322 aa overlap. pseudogene (upstream sequence matches homologs). ORF ftt1194c; lipoprotein 1211388 3192282 FTT_1194c Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_170154.1 1210462 R 177416 CDS YP_170155.1 56708259 3192271 complement(1213063..1214346) 1 NC_006570.2 Similar to Q9ZC87 Proline/betaine transporter (PROP7) from Rickettsia prowazekii (423 aa). FASTA: opt: 746 Z-score: 810.0 E(): 3.2e-37 Smith-Waterman score: 746; 31.450identity in 407 aa overlap. ORF ftt1196c; major facilitator transporter 1214346 3192271 FTT_1196c Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_170155.1 1213063 R 177416 CDS YP_170156.1 56708260 3192033 complement(1214431..1215228) 1 NC_006570.2 Similar to MURI_NEIMC (Q9RMM3) Glutamate racemase (EC 5.1.1.3) from Neisseria meningitidis (serogroup C) (270 aa). FASTA: opt: 826 Z-score: 958.8 E(): 1.6e-45 Smith-Waterman score: 826; 48.473identity in 262 aa overlap.; glutamate racemase 1215228 murI 3192033 murI Francisella tularensis subsp. tularensis SCHU S4 glutamate racemase YP_170156.1 1214431 R 177416 CDS YP_170157.1 56708261 3192270 complement(1215228..1216058) 1 NC_006570.2 ORF ftt1198c; hypothetical protein 1216058 3192270 FTT_1198c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170157.1 1215228 R 177416 CDS YP_170158.1 56708262 3191920 complement(1216062..1218068) 1 NC_006570.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1218068 uvrB 3191920 uvrB Francisella tularensis subsp. tularensis SCHU S4 excinuclease ABC subunit B YP_170158.1 1216062 R 177416 CDS YP_170159.1 56708263 3191444 complement(1218070..1219518) 1 NC_006570.2 Similar to Q83BX4 Exodeoxyribonuclease I, from Coxiella burnetii (458 aa). FASTA: opt: 677 Z-score: 797.9 E(): 1.5e-36 Smith-Waterman score: 1190; 39.875 identity in 479 aa overlap.; exodeoxyribonuclease I 1219518 sbcB 3191444 sbcB Francisella tularensis subsp. tularensis SCHU S4 exodeoxyribonuclease I YP_170159.1 1218070 R 177416 CDS YP_170160.1 56708264 3192265 complement(1219652..1220374) 1 NC_006570.2 Similar to Q9KKP5 Oxidoreductase,short-chain dehydrogenase/reductase family from Vibrio cholerae (239 aa). FASTA: opt: 1097 Z-score: 1344.5 E(): 5.4e-67 Smith-Waterman score: 1097; 72.458identity in 236 aa overlap. ORF ftt1201c; short-chain dehydrogenase family oxidoreductase 1220374 3192265 FTT_1201c Francisella tularensis subsp. tularensis SCHU S4 short-chain dehydrogenase family oxidoreductase YP_170160.1 1219652 R 177416 CDS YP_170161.1 56708265 3192261 1220490..1221389 1 NC_006570.2 Similar to Q9KKP4 Transcriptional regulator, LysR family from Vibrio cholerae (301 aa). FASTA: opt: 661 Z-score: 794.3 E(): 2.4e-36 Smith-Waterman score: 661; 36.120identity in 299 aa overlap. ORF ftt1202; LysR family transcriptional regulator 1221389 3192261 FTT_1202 Francisella tularensis subsp. tularensis SCHU S4 LysR family transcriptional regulator YP_170161.1 1220490 D 177416 CDS YP_170162.1 56708266 3192257 complement(1221400..1222305) 1 NC_006570.2 ORF ftt1203c; hypothetical protein 1222305 3192257 FTT_1203c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170162.1 1221400 R 177416 CDS YP_170163.1 56708267 3192253 complement(1222292..1223374) 1 NC_006570.2 ORF ftt1204c; hypothetical protein 1223374 3192253 FTT_1204c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170163.1 1222292 R 177416 CDS YP_170164.1 56708268 3192517 1223517..1225400 1 NC_006570.2 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 1225400 gidA 3192517 gidA Francisella tularensis subsp. tularensis SCHU S4 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_170164.1 1223517 D 177416 CDS YP_170165.1 56708269 3192252 1225412..1225804 1 NC_006570.2 ORF ftt1206; hypothetical protein 1225804 3192252 FTT_1206 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170165.1 1225412 D 177416 CDS YP_170166.1 56708270 3192249 1225818..1227188 1 NC_006570.2 ORF ftt1207; hypothetical protein 1227188 3192249 FTT_1207 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170166.1 1225818 D 177416 CDS YP_170167.1 56708271 3192024 1227190..1227864 1 NC_006570.2 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 1227864 rpiA 3192024 rpiA Francisella tularensis subsp. tularensis SCHU S4 ribose-5-phosphate isomerase A YP_170167.1 1227190 D 177416 CDS YP_170168.1 56708272 3190805 complement(join(1229938..1230396,1230396..1230722)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1230722 isftu1 3190805 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170168.1 1229938 R 177416 CDS YP_170169.1 56708273 3192240 complement(1230784..1231176) 1 NC_006570.2 CDS is disrupted by the insertion of an ISFtu1 element occurring very near the C-terminal end. It is not clear whether this insertion affects the function of the protein ORF ftt1211c; hypothetical protein 1231176 3192240 FTT_1211c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170169.1 1230784 R 177416 CDS YP_170170.1 56708274 3192332 complement(1231176..1231559) 1 NC_006570.2 Similar to LGUL_VIBPA (P46235) Probable lactoylglutathione lyase from Vibrio parahaemolyticus (138 aa). FASTA: opt: 549 Z-score: 759.1 E(): 2.2e-34 Smith-Waterman score: 549; 64.516 identity in 124 aa overlap.; lactoylglutathione lyase 1231559 gloA 3192332 gloA Francisella tularensis subsp. tularensis SCHU S4 lactoylglutathione lyase YP_170170.1 1231176 R 177416 CDS YP_170171.1 56708275 3192236 1231675..1232388 1 NC_006570.2 Similar to YPDP_BACSU (P54163) Hypothetical protein ypdP from Bacillus subtilis (229 aa). FASTA: opt: 472 Z-score: 563.3 E(): 1.7e-23 Smith-Waterman score: 472; 40.435 identity in 230 aa overlap. ORF ftt1213; hypothetical protein 1232388 3192236 FTT_1213 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170171.1 1231675 D 177416 CDS YP_170172.1 56708276 3192234 complement(1232642..1233433) 1 NC_006570.2 Similar to Q8XN14 Hypothetical protein CPE0524 from Clostridium perfringens (264 aa). FASTA: opt: 486 Z-score: 584.5 E(): 1.1e-24 Smith-Waterman score: 486; 31.939 identity in 263 aa overlap. ORF ftt1214c; haloacid dehalogenase 1233433 3192234 FTT_1214c Francisella tularensis subsp. tularensis SCHU S4 haloacid dehalogenase YP_170172.1 1232642 R 177416 CDS YP_170173.1 56708277 3191648 complement(1234068..1235090) 1 NC_006570.2 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 1235090 queA 3191648 queA Francisella tularensis subsp. tularensis SCHU S4 S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_170173.1 1234068 R 177416 CDS YP_170174.1 56708278 3192235 complement(1235110..1235571) 1 NC_006570.2 ORF ftt1216c; hypothetical protein 1235571 3192235 FTT_1216c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170174.1 1235110 R 177416 CDS YP_170175.1 56708279 3191940 complement(1235593..1236828) 1 NC_006570.2 Similar to Q83F72 VisC protein from Coxiella burnetii (411 aa). FASTA: opt: 645 Z-score: 778.5 E(): 1.8e-35 Smith-Waterman score: 858; 37.192 identity in 406 aa overlap.; monooxygenase family protein 1236828 visC 3191940 visC Francisella tularensis subsp. tularensis SCHU S4 monooxygenase family protein YP_170175.1 1235593 R 177416 CDS YP_170176.1 56708280 3191137 complement(1236818..1238029) 1 NC_006570.2 Similar to Q87UH4 2-octaprenyl-6-methoxyphenyl hydroxylase from Pseudomonas syringae (pv. tomato) (395 aa). FASTA: opt: 654 Z-score: 770.5 E(): 5e-35 Smith-Waterman score: 654; 32.143 identity in 392 aa overlap.; 2-octaprenyl-6-methoxyphenyl hydroxylase 1238029 ubiH 3191137 ubiH Francisella tularensis subsp. tularensis SCHU S4 2-octaprenyl-6-methoxyphenyl hydroxylase YP_170176.1 1236818 R 177416 CDS YP_170177.1 56708281 3192233 complement(1238038..1238574) 1 NC_006570.2 Similar to YGA1_PSEPK (Q88CI0) Hypothetical UPF0149 protein PP5201 from Pseudomonas putida (strain KT2440) (184 aa). FASTA: opt: 269 Z-score: 349.3 E(): 1.4e-11 Smith-Waterman score: 269; 34.637identity in 179 aa overlap. ORF ftt1219c; hypothetical protein 1238574 3192233 FTT_1219c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170177.1 1238038 R 177416 CDS YP_170178.1 56708282 3192232 1238975..1239523 1 NC_006570.2 Similar to Q8ZM70 ligase from Salmonella typhimurium (182 aa). FASTA: opt: 317 Z-score: 411.1 E(): 5.2e-15 Smith-Waterman score: 317; 32.727 identity in 165 aa overlap. ORF ftt1220; 5-formyltetrahydrofolate cyclo-ligase 1239523 3192232 FTT_1220 Francisella tularensis subsp. tularensis SCHU S4 5-formyltetrahydrofolate cyclo-ligase YP_170178.1 1238975 D 177416 CDS YP_170179.1 56708283 3192229 1239526..1239792 1 NC_006570.2 ORF ftt1221; hypothetical protein 1239792 3192229 FTT_1221 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170179.1 1239526 D 177416 CDS YP_170180.1 56708284 3191509 1239799..1240425 1 NC_006570.2 Similar to Q89YU2 Conserved hypothetical protein, membrane protein from Bacteroides thetaiotaomicron (213 aa). FASTA: opt: 602 Z-score: 702.4 E(): 3.1e-31 Smith-Waterman score: 602; 42.857identity in 210 aa overlap.; DedA family protein 1240425 dedA2 3191509 dedA2 Francisella tularensis subsp. tularensis SCHU S4 DedA family protein YP_170180.1 1239799 D 177416 CDS YP_170181.1 56708285 3191510 1240481..1241128 1 NC_006570.2 Similar to Q8R8Y8 Hypothetical protein DedA2 from Thermoanaerobacter tengcongensis (209 aa). FAST: opt: 674 Z-score: 828.7 E(): 2.9e-38 Smith-Waterman score: 674; 45.894 identity in 207 aa overlap.; DedA family protein 1241128 dedA1 3191510 dedA1 Francisella tularensis subsp. tularensis SCHU S4 DedA family protein YP_170181.1 1240481 D 177416 CDS YP_170182.1 56708286 3191635 complement(1241204..1241902) 1 NC_006570.2 Similar to RECO_VIBVU (Q8DC74) DNA repair protein recO from Vibrio vulnificus (243 aa). FASTA: opt: 244 Z-score: 288.3 E(): 3.6e-08 Smith-Waterman score: 244; 29.130 identity in 230 aa overlap.; DNA repair protein RecO 1241902 recO 3191635 recO Francisella tularensis subsp. tularensis SCHU S4 DNA repair protein RecO YP_170182.1 1241204 R 177416 CDS YP_170183.1 56708287 3192227 complement(1241886..1242215) 1 NC_006570.2 ORF ftt1225c; hypothetical protein 1242215 3192227 FTT_1225c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170183.1 1241886 R 177416 CDS YP_170184.1 56708288 3191911 complement(1242208..1243383) 1 NC_006570.2 Similar to ISCS_VIBCH (Q9KTY2) Cysteine desulfurase (EC 4.4.1.-) from Vibrio cholerae (404 aa). FASTA: opt: 1104 Z-score: 1336.0 E(): 1.6e-66 Smith-Waterman score: 1104; 45.812 identity in 382 aa overlap.; cysteine desulfurase 1243383 iscS 3191911 iscS Francisella tularensis subsp. tularensis SCHU S4 cysteine desulfurase YP_170184.1 1242208 R 177416 CDS YP_170185.1 56708289 3191610 1243633..1246290 1 NC_006570.2 Similar to Q9KQG8 Ribonuclease E from Vibrio cholerae (1052 aa). FASTA: opt: 1928 Z-score: 1743.2 E(): 3.3e-89 Smith-Waterman score: 1943; 43.377 identity in 770 aa overlap.; ribonuclease E 1246290 rne 3191610 rne Francisella tularensis subsp. tularensis SCHU S4 ribonuclease E YP_170185.1 1243633 D 177416 CDS YP_170186.1 56708290 3190760 1246305..1247111 1 NC_006570.2 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1247111 lgt 3190760 lgt Francisella tularensis subsp. tularensis SCHU S4 prolipoprotein diacylglyceryl transferase YP_170186.1 1246305 D 177416 CDS YP_170187.1 56708291 3190786 1247096..1247920 1 NC_006570.2 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 1247920 thyA 3190786 thyA Francisella tularensis subsp. tularensis SCHU S4 thymidylate synthase YP_170187.1 1247096 D 177416 CDS YP_170188.1 56708292 3191850 1247923..1249167 1 NC_006570.2 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 1249167 serA 3191850 serA Francisella tularensis subsp. tularensis SCHU S4 D-3-phosphoglycerate dehydrogenase YP_170188.1 1247923 D 177416 CDS YP_170189.1 56708293 3191862 1249168..1250364 1 NC_006570.2 Similar to Q83BJ9 MesJ protein from Coxiella burnetii (449 aa). FASTA: opt: 639 Z-score: 733.1 E(): 6.1e-33 Smith-Waterman score: 726; 31.387identity in 411 aa overlap. Thought to be a cell cycle protein; PP-loop family protein 1250364 mesJ 3191862 mesJ Francisella tularensis subsp. tularensis SCHU S4 PP-loop family protein YP_170189.1 1249168 D 177416 CDS YP_170190.1 56708294 3190831 join(1250509..1250835,1250835..1251293) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1251293 isftu1 3190831 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170190.1 1250509 D 177416 CDS YP_170191.1 56708295 3191280 complement(1251367..1252695) 1 NC_006570.2 Similar to YJDL_ECOLI (P39276) Hypothetical transporter yjdL from Escherichia coli (485 aa).FASTA: opt: 1064 Z-score: 1135.9 E(): 2.2e-55 Smith-Waterman score: 1064; 38.222 identity in 450 aa overlap.This CDS is disrupted by the insertion of an ISFtu1 element occurring very near the C-terminal end. It is not clear whether this insertion affects the function of the protein; proton-dependent oligopeptide transport (POT) family protein 1252695 yjdL 3191280 yjdL Francisella tularensis subsp. tularensis SCHU S4 proton-dependent oligopeptide transport (POT) family protein YP_170191.1 1251367 R 177416 CDS YP_170192.1 56708296 3192226 1252946..1254091 1 NC_006570.2 Similar to Q8YIA2 Choloylglycine hydrolase (EC 3.5.1.24) from Brucella melitensis (367 aa). FASTA: opt: 387 Z-score: 460.1 E(): 9.7e-18 Smith-Waterman score: 574; 34.718 identity in 337 aa overlap. ORF ftt1234; choloylglycine hydrolase family protein 1254091 3192226 FTT_1234 Francisella tularensis subsp. tularensis SCHU S4 choloylglycine hydrolase family protein YP_170192.1 1252946 D 177416 CDS YP_170193.1 56708297 3190861 complement(1254092..1255156) 1 NC_006570.2 Similar to Q8FZH8 Lipopolysaccharide core biosynthesis mannosyltransferase LpcC from Brucella suis (354 aa). FASTA: opt: 825 Z-score: 1005.6 E(): 4e-48 Smith-Waterman score: 825; 38.352 identity in 352 aa overlap.; glycosyl transferase family protein 1255156 lpcC 3190861 lpcC Francisella tularensis subsp. tularensis SCHU S4 glycosyl transferase family protein YP_170193.1 1254092 R 177416 CDS YP_170194.1 56708298 3192220 1255326..1256414 1 NC_006570.2 ORF ftt1236; hypothetical protein 1256414 3192220 FTT_1236 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170194.1 1255326 D 177416 CDS YP_170195.1 56708299 3192224 1256422..1257312 1 NC_006570.2 Similar to Q8A3T1 stress protein from Bacteroides thetaiotaomicron (309 aa). FASTA: opt: 308 Z-score: 375.2 E(): 5.2e-13 Smith-Waterman score: 348; 26.599 identity in 297 aa overlap. ORF ftt1237; glycosyl transferase family protein 1257312 3192224 FTT_1237 Francisella tularensis subsp. tularensis SCHU S4 glycosyl transferase family protein YP_170195.1 1256422 D 177416 CDS YP_170196.1 56708300 3192211 complement(1257338..1258669) 1 NC_006570.2 ORF ftt1238c; hypothetical protein 1258669 3192211 FTT_1238c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170196.1 1257338 R 177416 CDS YP_170197.1 56708301 3192217 1258877..1260148 1 NC_006570.2 ORF ftt1239; hypothetical protein 1260148 3192217 FTT_1239 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170197.1 1258877 D 177416 CDS YP_170198.2 255961460 3192214 complement(1260163..1260711) 1 NC_006570.2 Similar to YJGA_HAEIN (P45076) Hypothetical protein HI1151 from Haemophilus influenzae (178 aa). FASTA: opt: 359 Z-score: 390.6 E(): 7.3e-14 Smith-Waterman score: 359; 35.928 identity in 167 aa overlap. ORF ftt1240c; hypothetical protein 1260711 3192214 FTT_1240c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170198.2 1260163 R 177416 CDS YP_170199.1 56708303 3191778 1260815..1262068 1 NC_006570.2 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 1262068 glyA 3191778 glyA Francisella tularensis subsp. tularensis SCHU S4 serine hydroxymethyltransferase YP_170199.1 1260815 D 177416 CDS YP_170200.1 56708304 3192215 1262350..1263612 1 NC_006570.2 ORF ftt1242; hypothetical protein 1263612 3192215 FTT_1242 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170200.1 1262350 D 177416 CDS YP_170201.1 56708305 3192019 complement(1263494..1265347) 1 NC_006570.2 Similar to EAA32028 Hypothetical protein from Neurospora crassa (567 aa). FASTA: opt: 643 Z-score: 759.7 E(): 2e-34 Smith-Waterman score: 793; 29.879 identity in 579 aa overlap.; FAD binding family protein 1265347 mreA 3192019 mreA Francisella tularensis subsp. tularensis SCHU S4 FAD binding family protein YP_170201.1 1263494 R 177416 CDS YP_170202.1 56708306 3192165 complement(1265424..1266248) 1 NC_006570.2 Similar to Q8XYX9 Probable transmembrane protein from Ralstonia solanacearum (Pseudomonas solanacearum) (289 aa). FASTA: opt: 563 Z-score: 689.8 E(): 1.6e-30 Smith-Waterman score: 563; 32.558 identity in 258 aa overlap.; lipoprotein 1266248 yfiO 3192165 yfiO Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_170202.1 1265424 R 177416 CDS YP_170203.1 56708307 3191615 1266337..1267335 1 NC_006570.2 Similar to Q87S65 Ribosomal large subunit pseudouridine from Vibrio parahaemolyticus (325 aa). FASTA: opt: 917 Z-score: 1118.2 E(): 2.2e-54 Smith-Waterman score: 917; 47.468 identity in 316 aa overlap.; ribosomal large subunit pseudouridine synthase D 1267335 rluD 3191615 rluD Francisella tularensis subsp. tularensis SCHU S4 ribosomal large subunit pseudouridine synthase D YP_170203.1 1266337 D 177416 CDS YP_170204.1 56708308 3192204 1267277..1268125 1 NC_006570.2 Similar to Q8EEM6 Bax protein, from Shewanella oneidensis (255 aa). FASTA: opt: 369 Z-score: 448.5 E(): 4.3e-17 Smith-Waterman score: 369; 31.081 identity in 222 aa overlap. ORF ftt1246; hypothetical protein 1268125 3192204 FTT_1246 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170204.1 1267277 D 177416 CDS YP_170205.1 56708309 3192202 1268200..1269300 1 NC_006570.2 Similar to Q9A5X9 ABC transporter,permease protein, from Caulobacter crescentus.(371 aa). FASTA: opt: 755 Z-score: 860.3 E(): 5e-40 Smith-Waterman score: 755; 36.095 identity in 338 aa overlap. ORF ftt1247; ABC transporter permease 1269300 3192202 FTT_1247 Francisella tularensis subsp. tularensis SCHU S4 ABC transporter permease YP_170205.1 1268200 D 177416 CDS YP_170206.1 56708310 3192198 1269315..1270076 1 NC_006570.2 Similar to Q83DK2 ABC transporter,ATP-binding protein from Coxiella burnetii (268 aa). FASTA: opt: 674 Z-score: 783.9 E(): 9e-36 Smith-Waterman score: 674; 46.188 identity in 223 aa overlap. ORF ftt1248; ABC transporter ATP-binding protein 1270076 3192198 FTT_1248 Francisella tularensis subsp. tularensis SCHU S4 ABC transporter ATP-binding protein YP_170206.1 1269315 D 177416 CDS YP_170207.1 56708311 3192197 1270086..1270811 1 NC_006570.2 Similar to Q9HZ27 Hypothetical protein PA3213 from Pseudomonas aeruginosa (312 aa). FASTA: opt: 282 Z-score: 315.9 E(): 1.1e-09 Smith-Waterman score: 282; 23.661 identity in 224 aa overlap. The archetype (Rv0169) for mce related family proteins, was isolated as being necessary for colonization of, and survival within, the macrophage MEDLINE:93377076. ORF ftt1249; cell entry (mce) family protein 1270811 3192197 FTT_1249 Francisella tularensis subsp. tularensis SCHU S4 cell entry (mce) family protein YP_170207.1 1270086 D 177416 CDS YP_170208.1 56708312 3192195 1270816..1271514 1 NC_006570.2 ORF ftt1250; hypothetical protein 1271514 3192195 FTT_1250 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170208.1 1270816 D 177416 CDS YP_170209.1 56708313 3191080 complement(1271504..1272190) 1 NC_006570.2 Similar to Q8EDF8 Conserved hypothetical protein from Shewanella oneidensis (234 aa). FASTA: opt: 692 Z-score: 805.5 E(): 5.6e-37 Smith-Waterman score: 692; 44.828 identity in 232 aa overlap. ORF ftt1251c; hypothetical protein 1272190 3191080 FTT_1251c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170209.1 1271504 R 177416 CDS YP_170210.1 56708314 3192555 1272261..1272989 1 NC_006570.2 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 1272989 3192555 FTT_1252 Francisella tularensis subsp. tularensis SCHU S4 16S ribosomal RNA methyltransferase RsmE YP_170210.1 1272261 D 177416 CDS YP_170211.1 56708315 3191476 1273219..1274706 1 NC_006570.2 Similar to Q9KTB5 Proton/peptide symporter family protein from Vibrio cholerae (514 aa). FASTA: opt: 1234 Z-score: 1376.6 E(): 8.7e-69 Smith-Waterman score: 1245; 42.050identity in 478 aa overlap. ORF ftt1253; proton-dependent oligopeptide transport (POT) family protein 1274706 3191476 FTT_1253 Francisella tularensis subsp. tularensis SCHU S4 proton-dependent oligopeptide transport (POT) family protein YP_170211.1 1273219 D 177416 CDS YP_170212.1 56708316 3191870 1274814..1276505 1 NC_006570.2 Similar to Q89UU0 Long-chain-fatty-acid-CoA ligase from Bradyrhizobium japonicum (561 aa). FASTA: opt: 1308 Z-score: 1621.3 E(): 2.1e-82 Smith-Waterman score: 1308; 38.324 identity in 561 aa overlap.; acyl-CoA synthetase 1276505 fadD1 3191870 fadD1 Francisella tularensis subsp. tularensis SCHU S4 acyl-CoA synthetase YP_170212.1 1274814 D 177416 CDS YP_170213.1 56708317 3191460 complement(1276493..1277341) 1 NC_006570.2 Similar to Q8PAT1 Transcriptional regulator from Xanthomonas campestris (pv. campestris) (287 aa). FASTA: opt: 689 Z-score: 866.5 E(): 2.3e-40 Smith-Waterman score: 689; 37.354identity in 257 aa overlap. ORF ftt1255c; AraC family transcriptional regulator 1277341 3191460 FTT_1255c Francisella tularensis subsp. tularensis SCHU S4 AraC family transcriptional regulator YP_170213.1 1276493 R 177416 CDS YP_170214.1 56708318 3191559 1277485..1279014 1 NC_006570.2 Similar to Q83DE1 Drug resistance transporter, EmrB/QacA family from Coxiella burnetii (526 aa). FASTA: opt: 1037 Z-score: 1145.4 E(): 6.6e-56 Smith-Waterman score: 1037; 31.928 identity in 498 aa overlap.; major facilitator transporter 1279014 emrB 3191559 emrB Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_170214.1 1277485 D 177416 CDS YP_170215.1 56708319 3192360 1279036..1280058 1 NC_006570.2 Similar to Q83DE0 Multidrug resistance protein from Coxiella burnetii (331 aa). FASTA: opt: 742 Z-score: 834.3 E(): 1.4e-38 Smith-Waterman score: 742; 37.695 identity in 321 aa overlap.; HlyD family secretion protein 1280058 emrA1 3192360 emrA1 Francisella tularensis subsp. tularensis SCHU S4 HlyD family secretion protein YP_170215.1 1279036 D 177416 CDS YP_170216.1 56708320 3191474 1280068..1281540 1 NC_006570.2 Similar to Q93NK3 outer membrane protein from Pseudomonas syringae (pv. syringae) (475 aa). FASTA: opt: 594 Z-score: 697.2 E(): 6e-31 Smith-Waterman score: 594; 28.970 identity in 466 aa overlap. ORF ftt1258; outer membrane efflux protein 1281540 3191474 FTT_1258 Francisella tularensis subsp. tularensis SCHU S4 outer membrane efflux protein YP_170216.1 1280068 D 177416 CDS YP_170217.1 56708321 3190905 1281669..1282418 1 NC_006570.2 Similar to NADE_MYCPN (P75216) Probable NH(3)-dependent NAD(+) synthetase Mycoplasma pneumoniae (248 aa). FASTA: opt: 601 Z-score: 760.1 E(): 1.9e-34 Smith-Waterman score: 601; 40.928identity in 237 aa overlap.; NH(3)-dependent NAD(+) synthetase 1282418 nadE 3190905 nadE Francisella tularensis subsp. tularensis SCHU S4 NH(3)-dependent NAD(+) synthetase YP_170217.1 1281669 D 177416 CDS YP_170218.1 56708322 3191472 1282522..1282944 1 NC_006570.2 ORF ftt1260; hypothetical protein 1282944 3191472 FTT_1260 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170218.1 1282522 D 177416 CDS YP_170219.1 56708323 3190916 join(1283965..1284291,1284291..1284749) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1284749 isftu1 3190916 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170219.1 1283965 D 177416 CDS YP_170220.1 56708324 3191465 complement(1285041..1286036) 1 NC_006570.2 Duplicate of FTT0354 and FTT0378. ORF ftt1263c; hypothetical protein 1286036 3191465 FTT_1263c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170220.1 1285041 R 177416 CDS YP_170221.1 56708325 3190884 complement(join(1286965..1287423,1287423..1287749)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1287749 isftu1 3190884 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170221.1 1286965 R 177416 CDS YP_170222.1 56708326 3191272 complement(1287773..1288486) 1 NC_006570.2 Similar to YC10_PSEAE (Q9I4C8) Hypothetical protein PA1210 from Pseudomonas aeruginosa (232 aa). FASTA: opt: 602 Z-score: 765.5 E(): 9.5e-35 Smith-Waterman score: 602; 41.667 identity in 228 aa overlap. This CDS is disrupted by the insertion of an ISFtu1 element occurring very near the C-terminal end. It is not clear whether this insertion affects the function of the protein.; pirin 1288486 yhhW 3191272 yhhW Francisella tularensis subsp. tularensis SCHU S4 pirin YP_170222.1 1287773 R 177416 CDS YP_170223.1 56708327 3191463 1288586..1289482 1 NC_006570.2 Similar to Q8E7Z8 Transcriptional regulator, LysR family from Shewanella oneidensis (289 aa). FASTA: opt: 561 Z-score: 683.5 E(): 3.5e-30 Smith-Waterman score: 561; 32.423identity in 293 aa overlap. ORF ftt1267; LysR family transcriptional regulator 1289482 3191463 FTT_1267 Francisella tularensis subsp. tularensis SCHU S4 LysR family transcriptional regulator YP_170223.1 1288586 D 177416 CDS YP_170224.1 56708328 3191529 complement(1289496..1290620) 1 NC_006570.2 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 1290620 dnaJ1 3191529 dnaJ1 Francisella tularensis subsp. tularensis SCHU S4 molecular chaperone DnaJ YP_170224.1 1289496 R 177416 CDS YP_170225.1 56708329 3191531 complement(1290709..1292637) 1 NC_006570.2 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 1292637 dnaK 3191531 dnaK Francisella tularensis subsp. tularensis SCHU S4 molecular chaperone DnaK YP_170225.1 1290709 R 177416 CDS YP_170226.1 56708330 3191601 complement(1292738..1293325) 1 NC_006570.2 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 1293325 grpE 3191601 grpE Francisella tularensis subsp. tularensis SCHU S4 heat shock protein GrpE YP_170226.1 1292738 R 177416 CDS YP_170227.1 56708331 3191995 1293414..1294580 1 NC_006570.2 Similar to Q81ZZ6 membrane-bound lytic murein transglycosylase A transmembrane protein from Nitrosomonas europaea (440 aa). FASTA: opt: 821 Z-score: 989.7 E(): 3.1e-47 Smith-Waterman score: 821; 39.769 identity in 347 aa overlap.; membrane-bound lytic murein transglycosylase A (MLT) family protein 1294580 mltA 3191995 mltA Francisella tularensis subsp. tularensis SCHU S4 membrane-bound lytic murein transglycosylase A (MLT) family protein YP_170227.1 1293414 D 177416 CDS YP_170228.1 56708332 3191462 1294573..1295757 1 NC_006570.2 Similar to Q8KB91 Protoporphyrinogen oxidase, from Chlorobium tepidum (399 aa). FASTA: opt: 594 Z-score: 698.0 E(): 5.5e-31 Smith-Waterman score: 673; 31.552 identity in 393 aa overlap. ORF ftt1272; hypothetical protein 1295757 3191462 FTT_1272 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170228.1 1294573 D 177416 CDS YP_170229.3 255961461 3192012 1295869..1296324 1 NC_006570.2 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 1296324 rplM 3192012 rplM Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L13 YP_170229.3 1295869 D 177416 CDS YP_170230.2 395342362 3192545 1296340..1296729 1 NC_006570.2 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 1296729 rpsI 3192545 rpsI Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S9 YP_170230.2 1296340 D 177416 CDS YP_170231.1 56708335 3192495 1296789..1297406 1 NC_006570.2 Similar to O52734 Macrophage growth locus A from Francisella novicida strain U112 (205 aa). FASTA: opt: 1275 Z-score: 1587.7 E(): 1.5e-80 Smith-Waterman score: 1275; 99.512 identity in 205 aa overlap (1-205:1-205).; macrophage growth locus subunit A 1297406 mglA 3192495 mglA Francisella tularensis subsp. tularensis SCHU S4 macrophage growth locus subunit A YP_170231.1 1296789 D 177416 CDS YP_170232.1 56708336 3191082 1297408..1297815 1 NC_006570.2 Identical to O52735 Macrophage growth locus B from Francisella novicida strain U112 (135 aa).; ClpXP protease specificity-enhancing factor 1297815 mglB 3191082 mglB Francisella tularensis subsp. tularensis SCHU S4 ClpXP protease specificity-enhancing factor YP_170232.1 1297408 D 177416 CDS YP_170233.1 56708337 3191458 complement(1297812..1299083) 1 NC_006570.2 Similar to Q88EE1 Sodium-solute symporter, from Pseudomonas putida (strain KT2440) (459 aa). FASTA: opt: 279 Z-score: 311.8 E(): 1.8e-09 Smith-Waterman score: 300; 20.863identity in 417 aa overlap. ORF ftt1277c; sodium-solute symporter family protein 1299083 3191458 FTT_1277c Francisella tularensis subsp. tularensis SCHU S4 sodium-solute symporter family protein YP_170233.1 1297812 R 177416 CDS YP_170234.1 56708338 3191604 complement(1299076..1299639) 1 NC_006570.2 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1299639 rnhB 3191604 rnhB Francisella tularensis subsp. tularensis SCHU S4 ribonuclease HII YP_170234.1 1299076 R 177416 CDS YP_170235.1 56708339 3192166 complement(1299641..1300384) 1 NC_006570.2 Similar to Q8ZCR9 SpoU-family rRNA methylase from Yersinia pestis (257 aa). FASTA: opt: 688 Z-score: 847.8 E(): 2.5e-39 Smith-Waterman score: 688; 47.755 identity in 245 aa overlap.; SpoU rRNA methylase family protein 1300384 yfhQ 3192166 yfhQ Francisella tularensis subsp. tularensis SCHU S4 SpoU rRNA methylase family protein YP_170235.1 1299641 R 177416 CDS YP_170236.1 56708340 3191252 complement(1300377..1300832) 1 NC_006570.2 Similar to Q88PA0 Phosphotransferase system, nitrogen regulatory IIA protein from Pseudomonas putida (strain KT2440) (154 aa). FASTA: opt: 239 Z-score: 318.2 E(): 7.8e-10 Smith-Waterman score: 239; 26.316identity in 152 aa overlap.; PEP-dependent sugar PTS system family protein 1300832 ptsN 3191252 ptsN Francisella tularensis subsp. tularensis SCHU S4 PEP-dependent sugar PTS system family protein YP_170236.1 1300377 R 177416 CDS YP_170237.1 56708341 3191268 complement(1300869..1301165) 1 NC_006570.2 Similar to RP5M_PSEPK (P15592) Probable sigma(54) modulation protein from Pseudomonas putida (102 aa). FASTA: opt: 336 Z-score: 439.6 E(): 1.4e-16 Smith-Waterman score: 336; 54.839 identity in 93 aa overlap.; sigma-54 modulation protein 1301165 yhbH 3191268 yhbH Francisella tularensis subsp. tularensis SCHU S4 sigma-54 modulation protein YP_170237.1 1300869 R 177416 CDS YP_170238.1 56708342 3191455 1301284..1301529 1 NC_006570.2 ORF ftt1282; hypothetical protein 1301529 3191455 FTT_1282 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170238.1 1301284 D 177416 CDS YP_170239.1 56708343 3192196 1301535..1302887 1 NC_006570.2 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 1302887 trmE 3192196 trmE Francisella tularensis subsp. tularensis SCHU S4 tRNA modification GTPase TrmE YP_170239.1 1301535 D 177416 CDS YP_170240.1 56708344 3190792 complement(1302897..1303091) 1 NC_006570.2 ORF ftt1284c; hypothetical protein 1303091 3190792 FTT_1284c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170240.1 1302897 R 177416 CDS YP_170241.1 56708345 3190789 complement(1303123..1304013) 1 NC_006570.2 Similar to Q8D448 Transcriptional regulator from Vibrio vulnificus (303 aa). FASTA: opt: 372 Z-score: 436.1 E(): 2.1e-16 Smith-Waterman score: 372; 28.571 identity in 294 aa overlap. ORF ftt1285c; LysR family transcriptional regulator 1304013 3190789 FTT_1285c Francisella tularensis subsp. tularensis SCHU S4 LysR family transcriptional regulator YP_170241.1 1303123 R 177416 CDS YP_170242.1 56708346 3191274 1305421..1306344 1 NC_006570.2 Similar to Q9BH24 Cystathionine beta-synthase 5 from Trypanosoma cruzi (384 aa). FASTA: opt: 540 Z-score: 651.0 E(): 2.3e-28 Smith-Waterman score: 542; 31.494 identity in 308 aa overlap.; cystathionine beta-synthase 1306344 cbs 3191274 cbs Francisella tularensis subsp. tularensis SCHU S4 cystathionine beta-synthase YP_170242.1 1305421 D 177416 CDS YP_170243.1 56708347 3191091 1306598..1307167 1 NC_006570.2 Similar to Q8Z651 membrane protein from Salmonella typhi (204 aa). FASTA: opt: 462 Z-score: 553.9 E(): 5.9e-23 Smith-Waterman score: 462; 36.667 identity in 180 aa overlap. ORF ftt1288; hypothetical protein 1307167 3191091 FTT_1288 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170243.1 1306598 D 177416 CDS YP_170245.1 56708349 3192497 1314025..1316049 1 NC_006570.2 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 1316049 metG 3192497 metG Francisella tularensis subsp. tularensis SCHU S4 methionyl-tRNA synthetase YP_170245.1 1314025 D 177416 CDS YP_170246.1 56708350 3191093 1316015..1317289 1 NC_006570.2 Similar to EXUT_BACSU (O34456) Hexuronate transporter from Bacillus subtilis (422 aa). FASTA: opt: 655 Z-score: 716.7 E(): 5e-32 Smith-Waterman score: 659; 28.250 identity in 400 aa overlap. ORF ftt1291; major facilitator transporter 1317289 3191093 FTT_1291 Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_170246.1 1316015 D 177416 CDS YP_170247.1 56708351 3191094 complement(1317286..1317888) 1 NC_006570.2 Similar to Q88YM1 Hypothetical protein from Lactobacillus plantarum (215 aa). FASTA: opt: 420 Z-score: 532.1 E(): 9.5e-22 Smith-Waterman score: 420; 35.025 identity in 197 aa overlap. ORF ftt1292c; hypothetical protein 1317888 3191094 FTT_1292c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170247.1 1317286 R 177416 CDS YP_170248.1 56708352 3191096 complement(1317938..1318552) 1 NC_006570.2 Similar to Q9KSS8 Hypothetical protein VC1178 from Vibrio cholerae (206 aa). FASTA: opt: 558 Z-score: 715.6 E(): 5.8e-32 Smith-Waterman score: 558; 42.703 identity in 185 aa overlap. ORF ftt1293c; Sua5_yciO_yrdC family protein 1318552 3191096 FTT_1293c Francisella tularensis subsp. tularensis SCHU S4 Sua5_yciO_yrdC family protein YP_170248.1 1317938 R 177416 CDS YP_170249.1 56708353 3192218 1318613..1319143 1 NC_006570.2 Similar to ISPZ_RALSO (Q8XYL2) Probable intracellular septation protein from Ralstonia solanacearum (Pseudomonas solanacearum) (186 aa). FASTA: opt: 549 Z-score: 659.0 E(): 8.2e-29 Smith-Waterman score: 549; 38.150 identity in 173 aa overlap.; intracellular septation protein A family protein 1319143 ispZ 3192218 ispZ Francisella tularensis subsp. tularensis SCHU S4 intracellular septation protein A family protein YP_170249.1 1318613 D 177416 CDS YP_170250.1 56708354 3192511 complement(1319482..1320498) 1 NC_006570.2 Similar to GLK_ANASP (P58616) Glucokinase from Anabaena sp. (strain PCC 7120) (342 aa). FASTA: opt: 735 Z-score: 904.6 E(): 1.7e-42 Smith-Waterman score: 735; 36.735 identity in 343 aa overlap.; glucose kinase 1320498 glk1 3192511 glk1 Francisella tularensis subsp. tularensis SCHU S4 glucose kinase YP_170250.1 1319482 R 177416 CDS YP_170251.1 56708355 3192321 1320592..1321344 1 NC_006570.2 Similar to Q8D1I3 COQ5 methyltransferase from Yersinia pestis (251 aa). FASTA: opt: 1184 Z-score: 1440.7 E(): 2.4e-72 Smith-Waterman score: 1184; 70.800 identity in 250 aa overlap.; menaquinone biosynthesis methyltransferase 1321344 ubiE 3192321 ubiE Francisella tularensis subsp. tularensis SCHU S4 menaquinone biosynthesis methyltransferase YP_170251.1 1320592 D 177416 CDS YP_170252.1 56708356 3191097 1321328..1321933 1 NC_006570.2 ORF ftt1297; hypothetical protein 1321933 3191097 FTT_1297 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170252.1 1321328 D 177416 CDS YP_170253.1 56708357 3190824 1321926..1323584 1 NC_006570.2 Similar to Q83A88 Ubiquinone biosynthesis protein AarF, from Coxiella burnetii (541 aa). FASTA: opt: 1682 Z-score: 2006.3 E(): 7.3e-104 Smith-Waterman score: 1682; 48.269 identity in 520 aa overlap. unrelated to the ABC transporter proteins.; 2-polyprenylphenol 6-hydroxylase 1323584 ubiB 3190824 ubiB Francisella tularensis subsp. tularensis SCHU S4 2-polyprenylphenol 6-hydroxylase YP_170253.1 1321926 D 177416 CDS YP_170254.1 56708358 3192431 1323590..1323928 1 NC_006570.2 Similar to Q82WM8 HIT (Histidine triad) family from Nitrosomonas europaea (116 aa). FASTA: opt: 424 Z-score: 574.5 E(): 4.1e-24 Smith-Waterman score: 424; 53.571 identity in 112 aa overlap.; histidine triad (HIT) family protein 1323928 hitA 3192431 hitA Francisella tularensis subsp. tularensis SCHU S4 histidine triad (HIT) family protein YP_170254.1 1323590 D 177416 CDS YP_170255.1 56708359 3191100 complement(1323945..1324076) 1 NC_006570.2 ORF ftt1300c; hypothetical protein 1324076 3191100 FTT_1300c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170255.1 1323945 R 177416 CDS YP_170256.1 56708360 3191106 1325075..1325905 1 NC_006570.2 ORF ftt1302; hypothetical protein 1325905 3191106 FTT_1302 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170256.1 1325075 D 177416 CDS YP_170257.1 56708361 3191105 complement(1325907..1326782) 1 NC_006570.2 ORF ftt1303c; hypothetical protein 1326782 3191105 FTT_1303c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170257.1 1325907 R 177416 CDS YP_170258.1 56708362 3191254 complement(1326861..1327709) 1 NC_006570.2 Similar to MURB_THEMA (Q9X239) UDP-N-acetylenolpyruvoylglucosamine reductase from Thermotoga maritima (284 aa). FASTA: opt: 577 Z-score: 699.7 E(): 4.4e-31 Smith-Waterman score: 577; 39.273 identity in 275 aa overlap.; UDP-N-acetylenolpyruvoylglucosamine reductase 1327709 murB 3191254 murB Francisella tularensis subsp. tularensis SCHU S4 UDP-N-acetylenolpyruvoylglucosamine reductase YP_170258.1 1326861 R 177416 CDS YP_170259.1 56708363 3191251 complement(1327717..1329051) 1 NC_006570.2 Similar to Q814X9 UDP-N-acetylglucosamine 1-carboxyvinyltransferase from Bacillus cereus (strain ATCC 14579 / DSM 31) (434 aa). FASTA: opt: 697 Z-score: 859.3 E(): 5.6e-40 Smith-Waterman score: 765; 33.333 identity in 438 aa overlap.; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1329051 murA 3191251 murA Francisella tularensis subsp. tularensis SCHU S4 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_170259.1 1327717 R 177416 CDS YP_170260.1 56708364 3191567 complement(1328990..1330387) 1 NC_006570.2 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1330387 engA 3191567 engA Francisella tularensis subsp. tularensis SCHU S4 GTP-binding protein EngA YP_170260.1 1328990 R 177416 CDS YP_170261.1 56708365 3191107 complement(1330603..1331139) 1 NC_006570.2 ORF ftt1307c; hypothetical protein 1331139 3191107 FTT_1307c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170261.1 1330603 R 177416 CDS YP_170262.1 56708366 3191108 complement(1331184..1331792) 1 NC_006570.2 ORF ftt1308c; hypothetical protein 1331792 3191108 FTT_1308c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170262.1 1331184 R 177416 CDS YP_170263.1 56708367 3192424 complement(1332931..1334847) 1 NC_006570.2 Similar to FTSH_ECO57 (Q8X9L0) Cell division protease ftsH from Escherichia coli O157:H7 (644 aa). FASTA: opt: 2569 Z-score: 2823.5 E(): 2.2e-149 Smith-Waterman score: 2569; 60.125 identity in 642 aa overlap.; ATP-dependent metalloprotease 1334847 hflB 3192424 hflB Francisella tularensis subsp. tularensis SCHU S4 ATP-dependent metalloprotease YP_170263.1 1332931 R 177416 CDS YP_170264.1 56708368 3191279 1335070..1336476 1 NC_006570.2 Similar to Q8UHQ9 MFS permease from Agrobacterium tumefaciens (strain C58 / ATCC 33970) (475 aa). FASTA: opt: 757 Z-score: 760.1 E(): 1.9e-34 Smith-Waterman score: 766; 32.735 identity in 446 aa overlap.; major facilitator transporter 1336476 yieO 3191279 yieO Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_170264.1 1335070 D 177416 CDS YP_170265.1 56708369 3191913 complement(1336482..1339304) 1 NC_006570.2 Similar to UVRA_PSEAE (Q9HWG0) UvrABC system protein A (UvrA protein) from Pseudomonas aeruginosa (945 aa). FASTA: opt: 4062 Z-score: 4339.5 E():0 Smith-Waterman score: 4062; 63.800identity in 942 aa overlap.; DNA excision repair protein subunit A 1339304 uvrA 3191913 uvrA Francisella tularensis subsp. tularensis SCHU S4 DNA excision repair protein subunit A YP_170265.1 1336482 R 177416 CDS YP_170266.1 56708370 3191923 complement(1339343..1339825) 1 NC_006570.2 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1339825 greA 3191923 greA Francisella tularensis subsp. tularensis SCHU S4 transcription elongation factor GreA YP_170266.1 1339343 R 177416 CDS YP_170267.1 56708371 3191109 complement(1339859..1340443) 1 NC_006570.2 Similar to Q8EBJ4 Type IV pilus biogenesis protein (164 aa). FASTA: opt: 157 Z-score: 204.8 E(): 0.0016 Smith-Waterman score: 157; 27.607 identity in 163 aa overlap. The pili fiber building block protein has a highly distinct primary structure; a short positively charged leader sequence, and a highly conserved and highly hydrophobic amino-terminal domain which forms the core of the pilus fiber; A variety of studies suggest that the invariant glycine (G) at -1 is required for prepilin cleavage and assembly and that the glutamate (E) at + 5 is essential for assembly and efficient N-terminal methylation but not cleavage. The region near the carboxy terminus is often hydrophilic and is stabilized by one or two disulfide bridges that may be involved in recognition of receptors. The genes with these characteristics are usually termed pilA, pilE, pilV, pilW, pilX and FimU. (Mattick John S.. 'Type IV Pili and twitching motility'. Annu. Rev. Microbiol. 2002. 56:289-314.) This protein has all the characteristics described above, except the glutamate (E) at + 5, but shows a weak global homology. ORF ftt1314c; Type IV pili fiber building block protein 1340443 3191109 FTT_1314c Francisella tularensis subsp. tularensis SCHU S4 Type IV pili fiber building block protein YP_170267.1 1339859 R 177416 CDS YP_170268.1 56708372 3191335 complement(1340444..1342066) 1 NC_006570.2 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1342066 pgi 3191335 pgi Francisella tularensis subsp. tularensis SCHU S4 glucose-6-phosphate isomerase YP_170268.1 1340444 R 177416 CDS YP_170269.1 56708373 3191111 complement(1342053..1342706) 1 NC_006570.2 Similar to Q8R9T9 Thiamine pyrophosphokinase from Thermoanaerobacter tengcongensis (211 aa). FASTA: opt: 221 Z-score: 278.6 E(): 1.3e-07 Smith-Waterman score: 238; 25.943 identity in 212 aa overlap. ORF ftt1316c; thiamine pyrophospokinase 1342706 3191111 FTT_1316c Francisella tularensis subsp. tularensis SCHU S4 thiamine pyrophospokinase YP_170269.1 1342053 R 177416 CDS YP_170270.1 56708374 3192330 complement(1342772..1344232) 1 NC_006570.2 Similar to Q88P22 Inosine-5-monophosphate dehydrogenase from Pseudomonas putida (strain KT2440) (489 aa). FASTA: opt: 2187 Z-score: 2403.4 E(): 5.6e-126 Smith-Waterman score: 2187; 68.033 identity in 488 aa overlap.; inosine-5'-monophosphate dehydrogenase 1344232 guaB 3192330 guaB Francisella tularensis subsp. tularensis SCHU S4 inosine-5'-monophosphate dehydrogenase YP_170270.1 1342772 R 177416 CDS YP_170271.1 56708375 3191324 complement(1344333..1345772) 1 NC_006570.2 Similar to Q887M0 Cytosol aminopeptidase from Pseudomonas syringae (pv. tomato) (496 aa). FASTA: opt: 1161 Z-score: 1388.1 E(): 2e-69 Smith-Waterman score: 1165; 42.540 identity in 496 aa overlap.; cytosol aminopeptidase 1345772 pepA 3191324 pepA Francisella tularensis subsp. tularensis SCHU S4 cytosol aminopeptidase YP_170271.1 1344333 R 177416 CDS YP_170272.1 56708376 3191112 1345938..1347020 1 NC_006570.2 Similar to Q8EH61 Conserved hypothetical protein from Shewanella oneidensis (370 aa). FASTA: opt: 370 Z-score: 433.4 E(): 3e-16 Smith-Waterman score: 370; 21.508 identity in 358 aa overlap. ORF ftt1319; YjgP/YjgQ family permease 1347020 3191112 FTT_1319 Francisella tularensis subsp. tularensis SCHU S4 YjgP/YjgQ family permease YP_170272.1 1345938 D 177416 CDS YP_170273.1 56708377 3191114 1347020..1348081 1 NC_006570.2 Similar to Q8ZK26 permease from Salmonella typhimurium (360 aa). FASTA: opt: 510 Z-score: 585.0 E(): 1.1e-24 Smith-Waterman score: 511; 27.147 identity in 361 aa overlap. ORF ftt1320; YjgP/YjgQ family permease 1348081 3191114 FTT_1320 Francisella tularensis subsp. tularensis SCHU S4 YjgP/YjgQ family permease YP_170273.1 1347020 D 177416 CDS YP_170274.1 56708378 3191116 1348089..1349342 1 NC_006570.2 Similar to Q83AI4 Peptidase, M16 family from Coxiella burnetii (459 aa). FASTA: opt: 868 Z-score: 1053.1 E(): 9.1e-51 Smith-Waterman score: 868; 34.158 identity in 404 aa overlap. ORF ftt1321; peptidase M16 family protein 1349342 3191116 FTT_1321 Francisella tularensis subsp. tularensis SCHU S4 peptidase M16 family protein YP_170274.1 1348089 D 177416 CDS YP_170275.1 56708379 3191117 1349349..1350572 1 NC_006570.2 Similar to Q83AI5 Peptidase, M16 family from Coxiella burnetii (443 aa). FASTA: opt: 605 Z-score: 727.1 E(): 1.3e-32 Smith-Waterman score: 605; 28.607 identity in 402 aa overlap. ORF ftt1322; peptidase M16 family protein 1350572 3191117 FTT_1322 Francisella tularensis subsp. tularensis SCHU S4 peptidase M16 family protein YP_170275.1 1349349 D 177416 CDS YP_170276.1 56708380 3191119 1350573..1351151 1 NC_006570.2 Similar to YHHF_HAEIN (P44869) methylase HI0767 from Haemophilus influenzae (193 aa). FASTA: opt: 455 Z-score: 588.3 E(): 7e-25 Smith-Waterman score: 455; 42.697 identity in 178 aa overlap. ORF ftt1323; methylase 1351151 3191119 FTT_1323 Francisella tularensis subsp. tularensis SCHU S4 methylase YP_170276.1 1350573 D 177416 CDS YP_170277.1 56708381 3191120 1351185..1351835 1 NC_006570.2 Similar to Q9CM99 Hypothetical protein PM0935 from Pasteurella multocida (226 aa). FASTA: opt: 523 Z-score: 599.4 E(): 1.7e-25 Smith-Waterman score: 523; 39.151 identity in 212 aa overlap. ORF ftt1324; hypothetical protein 1351835 3191120 FTT_1324 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170277.1 1351185 D 177416 CDS YP_170278.1 56708382 3190883 complement(1351888..1352499) 1 NC_006570.2 Similar to Q88KV1 TRNA-(ms(2)io(6)a)-hydroxylase, from Pseudomonas putida (strain KT2440)(205 aa). FASTA: opt: 660 Z-score: 867.5 E(): 2e-40 Smith-Waterman score: 660; 50.777 identity in 193 aa overlap.; tRNA-(ms(2)io(6)a)-hydroxylase 1352499 miaE 3190883 miaE Francisella tularensis subsp. tularensis SCHU S4 tRNA-(ms(2)io(6)a)-hydroxylase YP_170278.1 1351888 R 177416 CDS YP_170279.1 56708383 3192475 1352615..1353418 1 NC_006570.2 Similar to Q9CKN8 Udp from Pasteurella multocida (252 aa). FASTA: opt: 817 Z-score: 1065.9 E(): 1.8e-51 Smith-Waterman score: 817; 48.760 identity in 242 aa overlap.; uridine phosphorylase 1353418 udp 3192475 udp Francisella tularensis subsp. tularensis SCHU S4 uridine phosphorylase YP_170279.1 1352615 D 177416 CDS YP_170280.1 56708384 3190961 1353439..1353840 1 NC_006570.2 Similar to Q8RCG7 Cytidine deaminase from Thermoanaerobacter tengcongensis (135 aa). FASTA: opt: 413 Z-score: 565.4 E(): 1.3e-23 Smith-Waterman score: 413; 52.273 identity in 132 aa overlap.; cytidine deaminase 1353840 cdd 3190961 cdd Francisella tularensis subsp. tularensis SCHU S4 cytidine deaminase YP_170280.1 1353439 D 177416 CDS YP_003097805.1 255961462 3191121 complement(1354038..1357067) 1 NC_006570.2 Similar to Q8EDV0 Oxidoreductase,FAD-binding, from Shewanella oneidensis (1013 aa).; FAD-binding family protein 1357067 3191121 FTT_1328c Francisella tularensis subsp. tularensis SCHU S4 FAD-binding family protein YP_003097805.1 1354038 R 177416 CDS YP_170281.1 56708385 3190945 1357287..1358825 1 NC_006570.2 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 1358825 gpmI 3190945 gpmI Francisella tularensis subsp. tularensis SCHU S4 phosphoglyceromutase YP_170281.1 1357287 D 177416 CDS YP_170282.1 56708386 3190714 1358840..1360120 1 NC_006570.2 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1360120 serS 3190714 serS Francisella tularensis subsp. tularensis SCHU S4 seryl-tRNA synthetase YP_170282.1 1358840 D 177416 CDS YP_170283.1 56708387 3191896 1360230..1361129 1 NC_006570.2 Similar to Q97IW7 Fructokinase from Clostridium acetobutylicum (288 aa). FASTA: opt: 932 Z-score: 1175.6 E(): 1.4e-57 Smith-Waterman score: 932; 47.603identity in 292 aa overlap.; fructokinase 1361129 cscK 3191896 cscK Francisella tularensis subsp. tularensis SCHU S4 fructokinase YP_170283.1 1360230 D 177416 CDS YP_170284.1 56708388 3191123 1361207..1362466 1 NC_006570.2 Similar to Q9X4C7 Repeat unit exporter from Escherichia coli (419 aa). FASTA: opt: 324 Z-score: 369.2 E(): 1.1e-12 Smith-Waterman score: 324; 22.604 identity in 407 aa overlap. ORF ftt1332; polysaccharide biosynthesis protein 1362466 3191123 FTT_1332 Francisella tularensis subsp. tularensis SCHU S4 polysaccharide biosynthesis protein YP_170284.1 1361207 D 177416 CDS YP_170285.1 56708389 3191125 complement(1362470..1362670) 1 NC_006570.2 ORF ftt1333c; hypothetical protein 1362670 3191125 FTT_1333c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170285.1 1362470 R 177416 CDS YP_170286.1 56708390 3191128 complement(1362698..1363207) 1 NC_006570.2 ORF ftt1334c; hypothetical protein 1363207 3191128 FTT_1334c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170286.1 1362698 R 177416 CDS YP_170287.1 56708391 3191909 1363584..1365365 1 NC_006570.2 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter permease/ATP-binding protein 1365365 cydD 3191909 cydD Francisella tularensis subsp. tularensis SCHU S4 cysteine/glutathione ABC transporter permease/ATP-binding protein YP_170287.1 1363584 D 177416 CDS YP_170288.1 56708392 3191906 1365362..1367011 1 NC_006570.2 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter permease/ATP-binding protein 1367011 cydC 3191906 cydC Francisella tularensis subsp. tularensis SCHU S4 cysteine/glutathione ABC transporter permease/ATP-binding protein YP_170288.1 1365362 D 177416 CDS YP_170289.1 56708393 3191503 complement(1367013..1368263) 1 NC_006570.2 Similar to DTA2_PSEAE (Q9I4F5) C4-dicarboxylate transport protein from Pseudomonas aeruginosa (436 aa). FASTA: opt: 1534 Z-score: 1703.1 E(): 5.7e-87 Smith-Waterman score: 1534; 55.206identity in 413 aa overlap.; C4-dicarboxylate transport protein 1368263 dctA 3191503 dctA Francisella tularensis subsp. tularensis SCHU S4 C4-dicarboxylate transport protein YP_170289.1 1367013 R 177416 CDS YP_170290.1 56708394 3191130 complement(1368402..1368782) 1 NC_006570.2 Similar to Q99WA6 SA0455 protein (Translation initiation inhibitor homologue) from Staphylococcus aureus (126 aa). FASTA: 452 opt: 452 Z-score: 597.7 E(): 2.1e-25 Smith-Waterman score: 452; 61.017 identity in 118 aa overlap. ORF ftt1338c; translation initiation inhibitor 1368782 3191130 FTT_1338c Francisella tularensis subsp. tularensis SCHU S4 translation initiation inhibitor YP_170290.1 1368402 R 177416 CDS YP_170291.1 56708395 3191572 complement(1368782..1370326) 1 NC_006570.2 Similar to Q87N13 Sulfate permease family protein from Vibrio parahaemolyticus (519 aa). FASTA: opt: 1333 Z-score: 1472.3 E(): 4.1e-74 Smith-Waterman score: 1602; 47.398 identity in 538 aa overlap. ORF ftt1339c; sulfate permease family protein 1370326 3191572 FTT_1339c Francisella tularensis subsp. tularensis SCHU S4 sulfate permease family protein YP_170291.1 1368782 R 177416 CDS YP_170292.1 56708396 3192307 complement(1370445..1371188) 1 NC_006570.2 ISFtu2. Transposase, member of the IS5 family. Identical to Q8GM03 transposase from Francisella tularensis (247 aa).; transposase 1371188 isftu2 3192307 isftu2 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170292.1 1370445 R 177416 CDS YP_170293.1 56708397 3191574 1371389..1372045 1 NC_006570.2 Similiar to CAD85637 (Q82TY8) integral membrane transmembrane protein from Nitrosomonas europaea (221 aa). FASTA: 670 Z-score: 817.1 E(): 1.2e-37 50.226identity in 221 aa overlap ORF ftt1341; hypothetical protein 1372045 3191574 FTT_1341 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170293.1 1371389 D 177416 CDS YP_170294.1 56708398 3191575 1372159..1373214 1 NC_006570.2 Similar to Q08861 Gamma-aminobutyric acid-grated chloride- ion channel/receptor, zeta subunit, precusor from Lymnaea stagnalis (437 aa). FASTA: opt: 357 Z-score: 407.4 E(): 7.7e-15 Smith-Waterman score: 360; 23.510 identity in 302 aa overlap ORF ftt1342; hypothetical protein 1373214 3191575 FTT_1342 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170294.1 1372159 D 177416 CDS YP_170295.1 56708399 3191576 complement(1373509..1374318) 1 NC_006570.2 ORF ftt1343c; hypothetical protein 1374318 3191576 FTT_1343c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170295.1 1373509 R 177416 CDS YP_170296.1 56708400 3191294 1379925..1382387 1 NC_006570.2 Similar to AAP58968.1 (Q7X3I9) PdpA from Francisella novicida (820 aa). BLAST Score = 1545 bits (4000), Expect = 0.0 Identities = 777/820 (94), Positives = 787/820 (95) Identical to FTT1699. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625; hypothetical protein 1382387 pdpA1 3191294 pdpA1 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170296.1 1379925 D 177416 CDS YP_170297.1 56708401 3191301 1382392..1385673 1 NC_006570.2 Similar to AAP58967.1 (Q7X3J0) PdpB from Francisella novicida (1093 aa). BLAST Score = 1914 bits (4959), Expect = 0.0 Identities = 975/1093 (89),Positives = 988/1093 (90) Identical to FTT1700. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625; hypothetical protein 1385673 pdpB1 3191301 pdpB1 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170297.1 1382392 D 177416 CDS YP_170298.1 56708402 3191570 1385663..1386040 1 NC_006570.2 Identical to FTT1701. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625 ORF ftt1346; hypothetical protein 1386040 3191570 FTT_1346 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170298.1 1385663 D 177416 CDS YP_170299.1 56708403 3191577 1386053..1386547 1 NC_006570.2 Similar to AAP58969.1 (Q7XI38) unknown protein from Francisella novicida (164 aa). BLAST Score = 305 bits (780), Expect = 2e-82 Identities = 163/164 (99),Positives = 163/164 (99) Identical to FTT1702. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625 ORF ftt1347; hypothetical protein 1386547 3191577 FTT_1347 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170299.1 1386053 D 177416 CDS YP_170300.1 56708404 3191578 1386552..1388282 1 NC_006570.2 1-213 aa similar to AAP58970.1 (Q7X3I7) unknown Francisella novicida (212 aa). BLAST Score 352 ,Expect = 1e-95 Identities = 177/209 (84), Positives = 189/209 (90). 330-580aa similar to AAP58971.1 (Q7X3I6) unknown protein from Francisella tularensis subsp. novicida (251 aa). BLAST Score = 483 bits (1244), Expect = e-135 Identities = 243/251 (96), Positives = 249/251 (99). Identical to FTT1703. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625. Protein fusion product of two hypothetical proteins in F. novicida. ORF ftt1348; hypothetical protein 1388282 3191578 FTT_1348 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170300.1 1386552 D 177416 CDS YP_170301.1 56708405 3191580 1388283..1388804 1 NC_006570.2 Similar to AAP58972.1 (Q7X3I5) unknown protein from Francisella novicida (173 aa). BLAST Score = 336, Expect = 1e-91 Identities = 170/173 (98), Positives = 171/173 (98) Identical to FTT1704. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625 ORF ftt1349; hypothetical protein 1388804 3191580 FTT_1349 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170301.1 1388283 D 177416 CDS YP_170302.1 56708406 3191581 1388817..1390247 1 NC_006570.2 Similar to AAP58973.1 (Q7X3I4) unknown protein from Francisella novicida (476 aa). BLAST Score = 864 bits (2233), Expect = 0.0 Identities = 433/476 (90),Positives = 437/476 (91) Identical to FTT1705. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625 ORF ftt1350; hypothetical protein 1390247 3191581 FTT_1350 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170302.1 1388817 D 177416 CDS YP_170303.1 56708407 3191586 1390260..1390883 1 NC_006570.2 Similar to AAP58974.1 (Q7X3I3) unknown protein from Francisella novicida (207 aa). BLAST Score = 391 bits (1005), Expect = e-108 Identities = 194/207 (93),Positives = 195/207 (94) Identical to FTT1706. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625 ORF ftt1351; hypothetical protein 1390883 3191586 FTT_1351 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170303.1 1390260 D 177416 CDS YP_170304.1 56708408 3191588 1390905..1392056 1 NC_006570.2 Similar to AAP58975.1 (Q7X3I2) unknown protein from Francisella novicida (262 aa), BLAST Score = 443 bits (1140), Expect = e-12 Identities = 229/262 (87),Positives = 235/262 (89) This protein is identical to FTT1707. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625 ORF ftt1352; hypothetical protein 1392056 3191588 FTT_1352 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170304.1 1390905 D 177416 CDS YP_170305.1 56708409 3191589 1392022..1392795 1 NC_006570.2 Similar to AAP58976.1 (Q7X3I1) unknown protein from Francisella novicida (257 aa). BLAST Score = 412, Expect = e-114 Identities = 213/257 (82), Positives = 213/257 (82) Identical to FTT1708. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625. ORF ftt1353; hypothetical protein 1392795 3191589 FTT_1353 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170305.1 1392022 D 177416 CDS YP_170306.1 56708410 3191593 1392835..1396821 1 NC_006570.2 Similar to AAP58966.1 PdpC from Francisella novicida (1218 aa). BLAST Score = 2172, Expect = 0.0 Identities = 1089/1220 (89), Positives = 1120/1220 (91),Gaps = 3/1220 (0) Identical to FTT1709. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625; hypothetical protein 1396821 pdpC1 3191593 pdpC1 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170306.1 1392835 D 177416 CDS YP_170307.1 56708411 3191594 1396839..1397414 1 NC_006570.2 Similar to AAP58977.1 (Q7X3I0) unknown protein from Francisella novicida (188 aa). BLAST Score = 321, Expect = 3e-87 Identities = 156/174 (89), Positives = 162/174 (93) Identical to FTT1710. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625 ORF ftt1355; hypothetical protein 1397414 3191594 FTT_1355 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170307.1 1396839 D 177416 CDS YP_170308.1 56708412 3191518 complement(1397421..1398626) 1 NC_006570.2 Similar to AAP58965.1 (Q7C3J6) IglD from Francisella novicida (398 aa). BLAST Score = 746, Expect = 0.0 Identities = 382/398 (95), Positives = 383/398 (96) Identical to FTT1711. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625; intracellular growth locus subunit D 1398626 iglD1 3191518 iglD1 Francisella tularensis subsp. tularensis SCHU S4 intracellular growth locus subunit D YP_170308.1 1397421 R 177416 CDS YP_170309.1 56708413 3191591 complement(1398638..1399273) 1 NC_006570.2 Similar to AAP58964.1 (Q7X3J5) IglC (23 kDa protein) from Francisella novicida (211 aa). BLAST Score = 405, Expect = e-112 Identities = 209/211 (99), Positives = 210/211 (99) Identical to FTT1712. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625; intracellular growth locus subunit C 1399273 iglC1 3191591 iglC1 Francisella tularensis subsp. tularensis SCHU S4 intracellular growth locus subunit C YP_170309.1 1398638 R 177416 CDS YP_170310.1 56708414 3191564 complement(1399284..1400828) 1 NC_006570.2 Similar to AAP58963.1 (Q7X3J4) IglB from Francisella novicida (514 aa). BLAST Score = 997, Expect = 0.0 Identities = 496/514 (96), Positives = 499/514 (97) Identical to FTT1713. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625; intracellular growth locus subunit B 1400828 iglB1 3191564 iglB1 Francisella tularensis subsp. tularensis SCHU S4 intracellular growth locus subunit B YP_170310.1 1399284 R 177416 CDS YP_170311.1 56708415 3191217 complement(1400818..1401408) 1 NC_006570.2 Similar to AAP58962.1 (Q7X3J5) IglA from Francisella novicida (184 aa). BLAST Score = 350, Expect = 6e-96 Identities = 181/184 (98), Positives = 181/184 (98) Identical to FTT1714. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625; intracellular growth locus subunit A 1401408 iglA1 3191217 iglA1 Francisella tularensis subsp. tularensis SCHU S4 intracellular growth locus subunit A YP_170311.1 1400818 R 177416 CDS YP_170312.1 56708416 3191310 complement(1401453..1405040) 1 NC_006570.2 Similar to AAP58961.1 (Q7C3J6) PdpD from Francisella novicida (1245 aa). BLAST Score = 2194, Expect = 0.0 Identities = 1133/1245 (91), Positives = 1154/1245 (92), Gaps = 50/1245 (4) Identical to FTT1715. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625; hypothetical protein 1405040 pdpD1 3191310 pdpD1 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170312.1 1401453 R 177416 CDS YP_170313.1 56708417 3190873 complement(join(1407396..1407854,1407854..1408180)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1408180 isftu1 3190873 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170313.1 1407396 R 177416 CDS YP_170314.1 56708418 3191878 complement(1410206..1411270) 1 NC_006570.2 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 1411270 fbaB 3191878 fbaB Francisella tularensis subsp. tularensis SCHU S4 fructose-1,6-bisphosphate aldolase YP_170314.1 1410206 R 177416 CDS YP_170315.1 56708419 3191657 complement(1411283..1412719) 1 NC_006570.2 Similar to AAO91275 (Q83AU7) Pyruvate kinase from Coxiella burnetii (477 aa). FASTA: opt: 1622 Z-score: 1687.6 E(): 3.8e-86 Smith-Waterman score: 1622; 53.249identity in 477 aa overlap domain, score 55.8, E-value 8.1e-14; pyruvate kinase 1412719 pyk 3191657 pyk Francisella tularensis subsp. tularensis SCHU S4 pyruvate kinase YP_170315.1 1411283 R 177416 CDS YP_170316.1 56708420 3191360 complement(1412735..1413913) 1 NC_006570.2 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1413913 pgk 3191360 pgk Francisella tularensis subsp. tularensis SCHU S4 phosphoglycerate kinase YP_170316.1 1412735 R 177416 CDS YP_170317.1 56708421 3191592 complement(1413932..1414978) 1 NC_006570.2 Similar to Q8XKT9 Glyceraldehyde-3-phosphate dehydrogenase from Clostridium perfringens (332 aa). FASTA: opt: 1511 Z-score: 1671.9 E(): 2.8e-85 Smith-Waterman score: 1511; 71.341identity in 328 aa overlap; glyceraldehyde-3-phosphate dehydrogenase 1414978 gapA 3191592 gapA Francisella tularensis subsp. tularensis SCHU S4 glyceraldehyde-3-phosphate dehydrogenase YP_170317.1 1413932 R 177416 CDS YP_170318.1 56708422 3190783 complement(1414971..1416962) 1 NC_006570.2 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1416962 tktA 3190783 tktA Francisella tularensis subsp. tularensis SCHU S4 transketolase YP_170318.1 1414971 R 177416 CDS YP_170319.1 56708423 3191598 1417102..1417605 1 NC_006570.2 Similar to AAN42711 (Q83LI4) Orf, conserved hypothetical protein from Shigella flexneri (173 aa). FASTA: opt: 194 Z-score: 254.2 E(): 2.6e-06 Smith-Waterman score: 194; 26.708 identity in 161 aa overlap ORF ftt1370; hypothetical protein 1417605 3191598 FTT_1370 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170319.1 1417102 D 177416 CDS YP_170320.1 56708424 3191613 1417649..1417831 1 NC_006570.2 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1417831 rpmF 3191613 rpmF Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L32 YP_170320.1 1417649 D 177416 CDS YP_170321.1 56708425 3191914 1417930..1418976 1 NC_006570.2 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1418976 plsX 3191914 plsX Francisella tularensis subsp. tularensis SCHU S4 glycerol-3-phosphate acyltransferase PlsX YP_170321.1 1417930 D 177416 CDS YP_170322.1 56708426 3191865 1419073..1420044 1 NC_006570.2 Similar to Q9JW56 3-oxoacyl-[acyl-carrier-protein] synthase III from Neisseria meningitidis (320 aa). FASTA: opt: 1148 Z-score: 1323.1 E(): 7.6e-66 Smith-Waterman score: 1148; 54.859 identity in 319 aa overlap; 3-oxoacyl-ACP synthase 1420044 fabH 3191865 fabH Francisella tularensis subsp. tularensis SCHU S4 3-oxoacyl-ACP synthase YP_170322.1 1419073 D 177416 CDS YP_170323.1 56708427 3191602 1420092..1421012 1 NC_006570.2 Similar to Q9CJS7 FabD from Pasteurella multocida (312 aa). FASTA: opt: 984 Z-score: 1099.0 E(): 2.3e-53 Smith-Waterman score: 984;50.163 identity in 307 aa overlap ORF ftt1374; malonyl CoA-ACP transacylase 1421012 3191602 FTT_1374 Francisella tularensis subsp. tularensis SCHU S4 malonyl CoA-ACP transacylase YP_170323.1 1420092 D 177416 CDS YP_170324.1 56708428 3191861 1421026..1421769 1 NC_006570.2 Similar to Q9CJS6 FabG from Pasteurella multocida (242 aa). FASTA: opt: 1029 Z-score: 1192.2 E(): 1.5e-58 Smith-Waterman score: 1029; 66.667 identity in 240 aa overlap; 3-oxoacyl-ACP reductase 1421769 fabG 3191861 fabG Francisella tularensis subsp. tularensis SCHU S4 3-oxoacyl-ACP reductase YP_170324.1 1421026 D 177416 CDS YP_170325.1 56708429 3192405 1421865..1422149 1 NC_006570.2 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1422149 acpP 3192405 acpP Francisella tularensis subsp. tularensis SCHU S4 acyl carrier protein YP_170325.1 1421865 D 177416 CDS YP_170326.1 56708430 3191863 1422229..1423488 1 NC_006570.2 Similar to Q8Y0J0 Probable 3-oxoacyl-[acyl-carrier-protein] synthase II from Ralstonia solanacearum (410 aa). FASTA: opt: 1679 Z-score: 1887.3 E(): 2.8e-97 Smith-Waterman score: 1679; 59.233 identity in 417 aa overlap; 3-oxoacyl-ACP synthase 1423488 fabF 3191863 fabF Francisella tularensis subsp. tularensis SCHU S4 3-oxoacyl-ACP synthase YP_170326.1 1422229 D 177416 CDS YP_008492914.1 537470117 3191482 complement(1423843..1424529) 1 NC_006570.2 hypothetical protein 1424529 3191482 FTT_1379c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_008492914.1 1423843 R 177416 CDS YP_170327.1 56708431 3190744 1427069..1427857 1 NC_006570.2 Similar to P22783 Inositol-1-monophosphatase from E. coli (267 aa). FASTA: opt: 630 Z-score: 759.0 E(): 2e-34 Smith-Waterman score: 656; 36.882identity in 263 aa overlap; inositol monophosphatase 1427857 suhB 3190744 suhB Francisella tularensis subsp. tularensis SCHU S4 inositol monophosphatase YP_170327.1 1427069 D 177416 CDS YP_170328.1 56708432 3190743 1427857..1429137 1 NC_006570.2 Similar to P44788 SUN protein (FMU protein) from Haemophilus influenzae (451 aa). FASTA: opt: 956 Z-score: 1079.4 E(): 2.9e-52 Smith-Waterman score: 956; 39.401 identity in 434 aa overlap; Sun protein 1429137 sun 3190743 sun Francisella tularensis subsp. tularensis SCHU S4 Sun protein YP_170328.1 1427857 D 177416 CDS YP_170329.1 56708433 3191485 complement(1429115..1429606) 1 NC_006570.2 Similar to Q8D9X5 Probable acetyltransferase from Vibrio vulnificus (141 aa). FASTA: opt: 183 Z-score: 242.0 E(): 1.3e-05 Smith-Waterman score: 183; 27.132 identity in 129 aa overlap ORF ftt1384c; acetyltransferase 1429606 3191485 FTT_1384c Francisella tularensis subsp. tularensis SCHU S4 acetyltransferase YP_170329.1 1429115 R 177416 CDS YP_170330.2 255961463 3191487 complement(1429699..1429968) 1 NC_006570.2 ORF ftt1385c; hypothetical protein 1429968 3191487 FTT_1385c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170330.2 1429699 R 177416 CDS YP_170331.1 56708435 3190917 join(1429959..1430285,1430285..1430743) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1430743 isftu1 3190917 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170331.1 1429959 D 177416 CDS YP_170332.1 56708436 3190767 complement(1431189..1433225) 1 NC_006570.2 Similar to P43813 DNA ligase from Haemophilus influenzae (679 aa). FASTA: opt: 2154 Z-score: 2353.2 E(): 3.2e-123 Smith-Waterman score: 2154; 48.817 identity in 676 aa overlap; DNA ligase 1433225 ligN 3190767 ligN Francisella tularensis subsp. tularensis SCHU S4 DNA ligase YP_170332.1 1431189 R 177416 CDS YP_170333.1 56708437 3191491 1433533..1434249 1 NC_006570.2 Similar to AAO81619 (Q833S4) Conserved domain protein from Enterococcus faecalis (281 aa). FASTA: opt: 171 Z-score: 214.0 E(): 0.00046 Smith-Waterman score: 194;26.337 identity in 243 aa overlap ORF ftt1388; hypothetical protein 1434249 3191491 FTT_1388 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170333.1 1433533 D 177416 CDS YP_170334.1 56708438 3191227 1434251..1435045 1 NC_006570.2 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 1435045 panB 3191227 panB Francisella tularensis subsp. tularensis SCHU S4 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_170334.1 1434251 D 177416 CDS YP_170335.1 56708439 3191378 1435032..1435817 1 NC_006570.2 Similar to AAO89975 (Q83EA3) Pantoate-beta-alanine ligase from Coxiella burnetii (257 aa). FASTA: opt: 692 Z-score: 830.8 E(): 2e-38 Smith-Waterman score: 692; 40.927 identity in 259 aa overlap; pantoate-beta-alanine ligase 1435817 panC 3191378 panC Francisella tularensis subsp. tularensis SCHU S4 pantoate-beta-alanine ligase YP_170335.1 1435032 D 177416 CDS YP_170336.1 56708440 3191388 1435811..1436146 1 NC_006570.2 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 1436146 panD 3191388 panD Francisella tularensis subsp. tularensis SCHU S4 aspartate alpha-decarboxylase YP_170336.1 1435811 D 177416 CDS YP_170337.1 56708441 3191493 1436150..1436920 1 NC_006570.2 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 1436920 3191493 FTT_1392 Francisella tularensis subsp. tularensis SCHU S4 pantothenate kinase YP_170337.1 1436150 D 177416 CDS YP_170338.1 56708442 3191640 complement(1436929..1438797) 1 NC_006570.2 Similar to Q9RPH5 RecD from Mycobacterium smegmatis (554 aa). FASTA: opt: 593 Z-score: 627.7 E(): 4.1e-27 Smith-Waterman score: 776; 32.510 identity in 486 aa overlap; exodeoxyribonuclease V subunit alpha 1438797 recD 3191640 recD Francisella tularensis subsp. tularensis SCHU S4 exodeoxyribonuclease V subunit alpha YP_170338.1 1436929 R 177416 CDS YP_170339.1 56708443 3191642 complement(1438763..1442416) 1 NC_006570.2 Similar to Q8EF45 Exodeoxyribonuclease V,beta subunit from Shewanella oneidensis (1259 aa). FASTA: opt: 742 Z-score: 770.7 E(): 4.5e-35 Smith-Waterman score: 1544; 30.448identity in 1317 aa overlap; exodeoxyribonuclease V subunit beta 1442416 recB 3191642 recB Francisella tularensis subsp. tularensis SCHU S4 exodeoxyribonuclease V subunit beta YP_170339.1 1438763 R 177416 CDS YP_170340.1 56708444 3192384 complement(1442488..1443918) 1 NC_006570.2 Similar Q8A303 ATP-dependent DNA helicase from Bacteriodes thetaiotamicron (511 aa). FASTA: opt: 496 Z-score: 533.4 E(): 7.4e-22 Smith-Waterman score: 815; 32.200 identity in 500 aa overlap ORF ftt1395c; ATP-dependent DNA helicase 1443918 3192384 FTT_1395c Francisella tularensis subsp. tularensis SCHU S4 ATP-dependent DNA helicase YP_170340.1 1442488 R 177416 CDS YP_170341.1 56708445 3192382 complement(1444061..1444639) 1 NC_006570.2 Similar to AAO81663 (Q833N3) Conserved hypothetical protein from Entercoccus faecalis (203 aa). FASTA: opt: 155 Z-score: 198.6 E(): 0.0033 Smith-Waterman score: 155; 25.850 identity in 147 aa overlap ORF ftt1396c; hypothetical protein 1444639 3192382 FTT_1396c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170341.1 1444061 R 177416 CDS YP_170342.1 56708446 3191641 complement(1444575..1447814) 1 NC_006570.2 Similar to P44945 Exodeoxyribonuclease V gamma chain from Haemophilus influenzae (1121 aa). FASTA: opt: 1139 Z-score: 1214.3 E(): 8.7e-60 Smith-Waterman score: 1433; 28.344 identity in 1129 aa overlap; exodeoxyribonuclease V subunit gamma 1447814 recC 3191641 recC Francisella tularensis subsp. tularensis SCHU S4 exodeoxyribonuclease V subunit gamma YP_170342.1 1444575 R 177416 CDS YP_170343.1 56708447 3192469 1449653..1450522 1 NC_006570.2 Similar to Q8KH10 Conserved hypothetical integral membrane (299 aa). FASTA: opt: 516 Z-score: 612.8 E(): 2.8e-26 Smith-Waterman score: 516; 29.818 identity in 275 aa overlap ORF ftt1399; hypothetical protein 1450522 3192469 FTT_1399 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170343.1 1449653 D 177416 CDS YP_170344.1 56708448 3190879 complement(1450536..1450922) 1 NC_006570.2 ORF ftt1400c; hypothetical protein 1450922 3190879 FTT_1400c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170344.1 1450536 R 177416 CDS YP_170345.1 56708449 3190880 1451079..1451744 1 NC_006570.2 Similar to Q8HA35 Repressor (217 aa). FASTA: opt: 183 Z-score: 217.7 E(): 0.00028 Smith-Waterman score: 225; 29.167 identity in 216 aa overlap ORF ftt1401; prophage repressor protein 1451744 3190880 FTT_1401 Francisella tularensis subsp. tularensis SCHU S4 prophage repressor protein YP_170345.1 1451079 D 177416 CDS YP_170346.1 56708450 3190795 complement(1452316..1453950) 1 NC_006570.2 ORF ftt1402c; hypothetical protein 1453950 3190795 FTT_1402c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170346.1 1452316 R 177416 CDS YP_170347.1 56708451 3191880 complement(1453967..1454191) 1 NC_006570.2 Similar to P33649 Ferrous iron transport protein A from E. coli (75 aa). FASTA: opt: 148 Z-score: 228.5 E(): 7.1e-05 Smith-Waterman score: 148; 31.081 identity in 74 aa overlap; ferrous iron transport protein A 1454191 feoA 3191880 feoA Francisella tularensis subsp. tularensis SCHU S4 ferrous iron transport protein A YP_170347.1 1453967 R 177416 CDS YP_170348.1 56708452 3190843 1454300..1455007 1 NC_006570.2 Similar to Q8E9Y6 Cell division protein FtsN from Shewanella oneidensis (231 aa). FASTA: opt: 157 Z-score: 187.2 E(): 0.014 Smith-Waterman score: 180; 27.094 identity in 203 aa overlap ORF ftt1404; cell division protein 1455007 3190843 FTT_1404 Francisella tularensis subsp. tularensis SCHU S4 cell division protein YP_170348.1 1454300 D 177416 CDS YP_170349.1 56708453 3192409 complement(1455085..1455843) 1 NC_006570.2 Similar to Q47677 Probable hydroxyacylglutathione hydrolase from E. coli (251 aa). FASTA: opt: 426 Z-score: 519.2 E(): 4.6e-21 Smith-Waterman score: 426; 36.290 identity in 248 aa overlap; hydroxyacylglutathione hydrolase 1455843 gloB 3192409 gloB Francisella tularensis subsp. tularensis SCHU S4 hydroxyacylglutathione hydrolase YP_170349.1 1455085 R 177416 CDS YP_170350.1 56708454 3190867 complement(1455857..1457014) 1 NC_006570.2 ORF ftt1406c; hypothetical protein 1457014 3190867 FTT_1406c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170350.1 1455857 R 177416 CDS YP_170351.1 56708455 3192327 complement(1457011..1458096) 1 NC_006570.2 ORF ftt1407c; hypothetical protein 1458096 3192327 FTT_1407c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170351.1 1457011 R 177416 CDS YP_170352.1 56708456 3192417 complement(1458062..1458811) 1 NC_006570.2 Similar to Q980U3 Uroporphyrinogen III synthase, from Sulfolobus solfataricus (237 aa). FASTA: opt: 171 Z-score: 213.0 E(): 0.00052 Smith-Waterman score: 171; 34.746 identity in 118 aa overlap; uroporphyrinogen III synthase 1458811 hemD 3192417 hemD Francisella tularensis subsp. tularensis SCHU S4 uroporphyrinogen III synthase YP_170352.1 1458062 R 177416 CDS YP_170353.1 56708457 3192474 complement(1458812..1459228) 1 NC_006570.2 Similar to Q8PK22 Hypothetical protein from Xanthomonas axonopodis (145 aa). FASTA: opt: 415 Z-score: 523.5 E(): 2.6e-21 Smith-Waterman score: 415; 45.652 identity in 138 aa overlap ORF ftt1409c; hypothetical protein 1459228 3192474 FTT_1409c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170353.1 1458812 R 177416 CDS YP_170354.1 56708458 3192484 1459926..1460471 1 NC_006570.2 Similar to Q8XTB4 Probable transmembrane protein from Ralstonia solanacearum (184 aa). FASTA: opt: 443 Z-score: 558.2 E(): 3e-23 Smith-Waterman score: 443; 42.045 identity in 176 aa overlap ORF ftt1410; hypothetical protein 1460471 3192484 FTT_1410 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170354.1 1459926 D 177416 CDS YP_170355.1 56708459 3191231 1463060..1464757 1 NC_006570.2 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1464757 proS 3191231 proS Francisella tularensis subsp. tularensis SCHU S4 prolyl-tRNA synthetase YP_170355.1 1463060 D 177416 CDS YP_170356.1 56708460 3192494 1464903..1466033 1 NC_006570.2 Similar to Q886Y5 Aminotransferase, classes I and II from Pseudomonas syringae (382 aa). FASTA: opt: 929 Z-score: 1036.9 E(): 6.6e-50 Smith-Waterman score: 929; 37.076 identity in 383 aa overlap ORF ftt1413; aminotransferase 1466033 3192494 FTT_1413 Francisella tularensis subsp. tularensis SCHU S4 aminotransferase YP_170356.1 1464903 D 177416 CDS YP_170357.1 56708461 3190816 1466033..1466515 1 NC_006570.2 ORF ftt1414; hypothetical protein 1466515 3190816 FTT_1414 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170357.1 1466033 D 177416 CDS YP_170358.1 56708462 3192313 1466623..1467525 1 NC_006570.2 ORF ftt1415; hypothetical protein 1467525 3192313 FTT_1415 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170358.1 1466623 D 177416 CDS YP_170359.1 56708463 3191965 complement(1467577..1467990) 1 NC_006570.2 ORF ftt1416c; lipoprotein 1467990 3191965 FTT_1416c Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_170359.1 1467577 R 177416 CDS YP_170360.1 56708464 3192491 1468144..1468929 1 NC_006570.2 Similar to Q8ZRJ8 amidohydrolase from Salmonella typhimurium (255 aa). FASTA: opt: 723 Z-score: 882.8 E(): 2.6e-41 Smith-Waterman score: 723; 43.359 identity in 256 aa overlap ORF ftt1417; carbon-nitrogen hydrolase 1468929 3192491 FTT_1417 Francisella tularensis subsp. tularensis SCHU S4 carbon-nitrogen hydrolase YP_170360.1 1468144 D 177416 CDS YP_170361.1 56708465 3191038 complement(1468913..1469338) 1 NC_006570.2 Similar to Q889Q5 N utilization substance protein B from Pseudomonas syringae (165 aa). FASTA: opt: 274 Z-score: 347.8 E(): 1.6e-11 Smith-Waterman score: 274; 32.847 identity in 137 aa overlap; N utilization substance protein B 1469338 nusB 3191038 nusB Francisella tularensis subsp. tularensis SCHU S4 N utilization substance protein B YP_170361.1 1468913 R 177416 CDS YP_170363.1 56708467 3190820 1469984..1470451 1 NC_006570.2 ORF ftt1420; hypothetical protein 1470451 3190820 FTT_1420 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170363.1 1469984 D 177416 CDS YP_170364.1 56708468 3190847 1470670..1471119 1 NC_006570.2 Similar to Q88E79 Conserved hypothetical protein from Pseudomonas putida (150 aa). FASTA: opt: 511 Z-score: 638.2 E(): 1.1e-27 Smith-Waterman score: 511; 46.809 identity in 141 aa overlap ORF ftt1421; hypothetical protein 1471119 3190847 FTT_1421 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170364.1 1470670 D 177416 CDS YP_170365.1 56708469 3191857 1471159..1471779 1 NC_006570.2 Similar to Q87UK0 Oxidoreductase, 2OG-Fe(II) oxygenase family (244 aa). FASTA: opt: 400 Z-score: 493.2 E(): 1.3e-19 33.163 identity in 196 aa overlap ORF ftt1422; oxidoreductase 1471779 3191857 FTT_1422 Francisella tularensis subsp. tularensis SCHU S4 oxidoreductase YP_170365.1 1471159 D 177416 CDS YP_170366.1 56708470 3192297 complement(1471772..1472521) 1 NC_006570.2 Similar to Q8NQW1 Predicted permease from Corynebacterium glutamicum (250 aa). FASTA: opt: 472 Z-score: 553.4 E(): 5.6e-23 Smith-Waterman score: 472; 35.573 identity in 253 aa overlap. ORF ftt1423c; hypothetical protein 1472521 3192297 FTT_1423c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170366.1 1471772 R 177416 CDS YP_170367.1 56708471 3192493 complement(1472523..1473203) 1 NC_006570.2 Similar to Q89VN8 Bll1007 protein from Bradyrhizobium japonicum (345 aa). FASTA: opt: 834 Z-score: 1018.3 E(): 7.2e-49 Smith-Waterman score: 834; 53.509 identity in 228 aa overlap ORF ftt1424c; hypothetical protein 1473203 3192493 FTT_1424c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170367.1 1472523 R 177416 CDS YP_170368.1 56708472 3192453 complement(1473248..1474942) 1 NC_006570.2 Similar to Q8XMF5 NADH oxidase from Clostridium perfringens (566 aa). FASTA: opt: 2055 Z-score: 2177.9 E(): 1.8e-113 57.117 identity in 548 aa overlap; NADH oxidase 1474942 naoX 3192453 naoX Francisella tularensis subsp. tularensis SCHU S4 NADH oxidase YP_170368.1 1473248 R 177416 CDS YP_170369.1 56708473 3190849 complement(1474964..1475482) 1 NC_006570.2 Similar to Q8YQC8 Hypothetical protein from Anabaena sp. (177 aa). FASTA: opt: 465 Z-score: 572.2 E(): 5e-24 Smith-Waterman score: 465; 43.023 identity in 172 aa overlap ORF ftt1426c; hypothetical protein 1475482 3190849 FTT_1426c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170369.1 1474964 R 177416 CDS YP_008492915.1 537470118 16744730 complement(1475548..1475847) 1 NC_006570.2 hypothetical protein 1475847 16744730 FTT_1426a Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_008492915.1 1475548 R 177416 CDS YP_170370.1 56708474 3190918 join(1476022..1476348,1476348..1476806) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1476806 isftu1 3190918 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170370.1 1476022 D 177416 CDS YP_170371.1 56708475 3192325 complement(1476967..1477482) 1 NC_006570.2 Similar to AAP10414 (Q81AS7) Acetyltransferase from Bacillus cereus (174 aa). FASTA: opt: 372 Z-score: 461.6 E(): 7.3e-18 Smith-Waterman score: 372; 40.341 identity in 176 aa overlap ORF ftt1428c; acetyltransferase 1477482 3192325 FTT_1428c Francisella tularensis subsp. tularensis SCHU S4 acetyltransferase YP_170371.1 1476967 R 177416 CDS YP_170372.1 56708476 3191627 1478662..1479297 1 NC_006570.2 Similar Q8DDM9 to threonine efflux protein from Vibrio vulnificus (223 aa). FASTA: opt: 310 Z-score: 386.3 E(): 1.1e-13 Smith-Waterman score: 310; 29.577 identity in 213 aa overlap; threonine efflux protein 1479297 rhtC 3191627 rhtC Francisella tularensis subsp. tularensis SCHU S4 threonine efflux protein YP_170372.1 1478662 D 177416 CDS YP_170373.1 56708477 3191987 complement(1479294..1480184) 1 NC_006570.2 Similar to Q89AR9 inorganic polyphosphate/ATP-NAD kinase from Buchnera aphidicola (292 aa). FASTA: opt: 682 Z-score: 800.3 E(): 1e-36 Smith-Waterman score: 682; 38.776 identity in 294 aa overlap; inorganic phosphate/ATP-NAD kinase 1480184 ppnK 3191987 ppnK Francisella tularensis subsp. tularensis SCHU S4 inorganic phosphate/ATP-NAD kinase YP_170373.1 1479294 R 177416 CDS YP_170374.1 56708478 3191777 1480373..1481317 1 NC_006570.2 Similar to Q55487 glycosyl transferase from Synechocystis sp. (318 aa). FASTA: opt: 1079 Z-score: 1283.0 E(): 1.3e-63 Smith-Waterman score: 1079; 50.000 identity in 298 aa overlap; glycosyl transferase family protein 1481317 gtrB 3191777 gtrB Francisella tularensis subsp. tularensis SCHU S4 glycosyl transferase family protein YP_170374.1 1480373 D 177416 CDS YP_170375.1 56708479 3192122 complement(1481321..1482100) 1 NC_006570.2 Similar Q88LN3 ABC transporter,permease protein from Pseudomonas putida (259 aa). FASTA: opt: 890 Z-score: 979.2 E(): 1.1e-46 Smith-Waterman score: 890; 50.193 identity in 259 aa overlap; ABC transporter permease 1482100 yadH 3192122 yadH Francisella tularensis subsp. tularensis SCHU S4 ABC transporter permease YP_170375.1 1481321 R 177416 CDS YP_170376.1 56708480 3192125 complement(1482109..1483032) 1 NC_006570.2 Similar to Q9CNG2 YagD from Pasteurella multocida (312 aa). FASTA: opt: 1028 Z-score: 1082.3 E(): 2e-52 Smith-Waterman score: 1028; 50.662 identity in 302 aa overlap; ABC transporter ATP-binding protein 1483032 yagD 3192125 yagD Francisella tularensis subsp. tularensis SCHU S4 ABC transporter ATP-binding protein YP_170376.1 1482109 R 177416 CDS YP_170377.1 56708481 3190848 1483215..1483958 1 NC_006570.2 ISFtu2. Transposase, member of the IS5 family. Identical to Q8GM03 transposase from Francisella tularensis (247 aa).; transposase 1483958 isftu2 3190848 isftu2 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170377.1 1483215 D 177416 CDS YP_170378.1 56708482 3190817 complement(1485237..1486004) 1 NC_006570.2 Similar to Q87N28 deoxyribonuclease from vibrio parahaemolyticus (255 aa). FASTA: opt: 787 Z-score: 917.1 E(): 3.1e-43 Smith-Waterman score: 787; 44.314 identity in 255 aa overlap ORF ftt1439c; deoxyribonuclease 1486004 3190817 FTT_1439c Francisella tularensis subsp. tularensis SCHU S4 deoxyribonuclease YP_170378.1 1485237 R 177416 CDS YP_170379.1 56708483 3190796 1487670..1488155 1 NC_006570.2 Similar to Q8YQ94 Hypothetical protein from Anabaena sp. (144 aa). FASTA: opt: 497 Z-score: 629.3 E(): 3.4e-27 Smith-Waterman score: 497; 54.610 identity in 141 aa overlap ORF ftt1441; hypothetical protein 1488155 3190796 FTT_1441 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170379.1 1487670 D 177416 CDS YP_170380.1 56708484 3191983 complement(1488773..1489729) 1 NC_006570.2 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 1489729 rpoA2 3191983 rpoA2 Francisella tularensis subsp. tularensis SCHU S4 DNA-directed RNA polymerase subunit alpha YP_170380.1 1488773 R 177416 CDS YP_170381.1 56708485 3192473 complement(1489817..1490719) 1 NC_006570.2 Similar to Q87ZS7 ATPase, AAA family from Pseudomonas syringae (440 aa). FASTA: opt: 1018 Z-score: 1104.6 E(): 1.1e-53 Smith-Waterman score: 1096; 43.243 identity in 407 aa overlap ORF ftt1443c; recombination factor protein RarA 1490719 3192473 FTT_1443c Francisella tularensis subsp. tularensis SCHU S4 recombination factor protein RarA YP_170381.1 1489817 R 177416 CDS YP_170382.1 56708486 3191242 complement(1491287..1492222) 1 NC_006570.2 Similar to P44828 exopolyphosphatase from Pneumophilus influenzae (323 aa). FASTA: opt: 730 Z-score: 856.9 E(): 7.1e-40 Smith-Waterman score: 730; 41.275 identity in 298 aa overlap; exopolyphosphatase 1492222 ppx 3191242 ppx Francisella tularensis subsp. tularensis SCHU S4 exopolyphosphatase YP_170382.1 1491287 R 177416 CDS YP_170383.1 56708487 3190999 1492411..1492734 1 NC_006570.2 Similar to Q9JYY9 Thioredoxin from Neisseria meningitidis (110 aa). FASTA: opt: 452 Z-score: 595.9 E(): 2.4e-25 Smith-Waterman score: 452; 62.000 identity in 100 aa overlap; thioredoxin 1492734 trxA1 3190999 trxA1 Francisella tularensis subsp. tularensis SCHU S4 thioredoxin YP_170383.1 1492411 D 177416 CDS YP_170384.1 56708488 3191628 1492777..1494039 1 NC_006570.2 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 1494039 rho 3191628 rho Francisella tularensis subsp. tularensis SCHU S4 transcription termination factor Rho YP_170384.1 1492777 D 177416 CDS YP_170385.1 56708489 3192273 complement(1495151..1496635) 1 NC_006570.2 Similar to Q8UCV4 Phosphomannomutase from Agrobacterium tumefaciens (506 aa). FASTA: opt: 1226 Z-score: 1345.0 E(): 4.6e-67 Smith-Waterman score: 1226; 41.127 identity in 479 aa overlap; phosphomannomutase 1496635 manB 3192273 manB Francisella tularensis subsp. tularensis SCHU S4 phosphomannomutase YP_170385.1 1495151 R 177416 CDS YP_170386.1 56708490 3191524 complement(1496666..1498072) 1 NC_006570.2 Similar to Q9ETR3 GDP-mannose pyrophosphorylase from Salmonella enterica (464 aa). FASTA: opt: 1571 Z-score: 1720.2 E(): 5.8e-88 Smith-Waterman score: 1571; 50.647 identity in 464 aa overlap; mannose-1-phosphate guanylyltransferase 1498072 manC 3191524 manC Francisella tularensis subsp. tularensis SCHU S4 mannose-1-phosphate guanylyltransferase YP_170386.1 1496666 R 177416 CDS YP_170387.1 56708491 3192100 complement(1499039..1500085) 1 NC_006570.2 Similar to Q9RDY1 RmlB protein from Legionella pneumophila (351 aa). FASTA: opt: 1490 Z-score: 1729.8 E(): 1.7e-88 Smith-Waterman score: 1490; 64.392 identity in 337 aa overlap; dTDP-D-glucose 4,6-dehydratase 1500085 wbtM 3192100 wbtM Francisella tularensis subsp. tularensis SCHU S4 dTDP-D-glucose 4,6-dehydratase YP_170387.1 1499039 R 177416 CDS YP_170388.1 56708492 3192089 complement(1500602..1501486) 1 NC_006570.2 Similar to O66250 Glucose-1-phosphate-thymidylyltransferase from Actinobacillus actinomycetemcomitans (290 aa). FASTA: opt: 1336 Z-score: 1567.4 E(): 1.9e-79 Smith-Waterman score: 1336; 67.466 identity in 292 aa overlap; glucose-1-phosphate thymidylyltransferase 1501486 wbtL 3192089 wbtL Francisella tularensis subsp. tularensis SCHU S4 glucose-1-phosphate thymidylyltransferase YP_170388.1 1500602 R 177416 CDS YP_170389.1 56708493 3192091 complement(1501511..1502371) 1 NC_006570.2 Similar to Q8ECG2 Glycosyl transferase, group 2 family protein from Shewanella oneidensis (298 aa). FASTA: opt: 724 Z-score: 845.9 E(): 2.9e-39 Smith-Waterman score: 724; 39.789 identity in 284 aa overlap; glycosyltransferase 1502371 wbtK 3192091 wbtK Francisella tularensis subsp. tularensis SCHU S4 glycosyltransferase YP_170389.1 1501511 R 177416 CDS YP_170390.1 56708494 3192113 complement(1502364..1503851) 1 NC_006570.2 Similar to AAO39697(Q84DG4) O antigen flippase from E. coli (464 aa). FASTA: opt: 861 Z-score: 954.5 E(): 2.6e-45 Smith-Waterman score: 861; 31.343identity in 469 aa overlap; O-antigen flippase 1503851 wzx 3192113 wzx Francisella tularensis subsp. tularensis SCHU S4 O-antigen flippase YP_170390.1 1502364 R 177416 CDS YP_170391.1 56708495 3192088 complement(1503856..1504581) 1 NC_006570.2 Similar to Q50721 Hypothetical protein Rv3404c precurser from Mycobacterium tuberculosis (234 aa). FASTA: opt: 562 Z-score: 656.5 E(): 1e-28 Smith-Waterman score: 562; 43.243 identity in 185 aa overlap; hypothetical protein 1504581 wbtJ 3192088 wbtJ Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170391.1 1503856 R 177416 CDS YP_170392.1 56708496 3192086 complement(1504578..1505660) 1 NC_006570.2 Similarity to Q97GL6 Sugar transaminase, involved in dTDP-4-amino-4,6-dideoxyglucose biosynthesis from Clostridium acetobutylicum (364 aa). FASTA: opt: 1344 Z-score: 1521.8 E(): 6.5e-77 Smith-Waterman score: 1344; 59.155 identity in 355 aa overlap; sugar transamine/perosamine synthetase 1505660 wbtI 3192086 wbtI Francisella tularensis subsp. tularensis SCHU S4 sugar transamine/perosamine synthetase YP_170392.1 1504578 R 177416 CDS YP_170393.1 56708497 3192087 complement(1505653..1507539) 1 NC_006570.2 Similar to Q8GGB6 Asparagine synthase-like protein from Pseudomonas aeruginosa (627 aa). FASTA: opt: 1855 Z-score: 2052.2 E(): 1.9e-106 Smith-Waterman score: 1855; 46.022 identity in 641 aa overlap; asparagine synthase 1507539 wbtH 3192087 wbtH Francisella tularensis subsp. tularensis SCHU S4 asparagine synthase YP_170393.1 1505653 R 177416 CDS YP_170394.1 56708498 3192084 complement(1507539..1508639) 1 NC_006570.2 Similar to Q8ECG6 Glycosyl transferase group 1 family protein from Shewanella oneidensis (373 aa). FASTA: opt: 531 Z-score: 625.5 E(): 5.5e-27 Smith-Waterman score: 531; 32.353 identity in 374 aa overlap; glycosyl transferase family protein 1508639 wbtG 3192084 wbtG Francisella tularensis subsp. tularensis SCHU S4 glycosyl transferase family protein YP_170394.1 1507539 R 177416 CDS YP_170395.1 56708499 3192114 complement(1508636..1509865) 1 NC_006570.2 membrane protein/O-antigen polymerase (personal communication from authors); membrane protein/O-antigen protein 1509865 wzy 3192114 wzy Francisella tularensis subsp. tularensis SCHU S4 membrane protein/O-antigen protein YP_170395.1 1508636 R 177416 CDS YP_170396.1 56708500 3192079 complement(1509882..1510853) 1 NC_006570.2 Similar to Q8KN66 WbpP from Pseudomonas aeruginosa (341 aa). FASTA: opt: 1033 Z-score: 1225.7 E(): 2e-60 Smith-Waterman score: 1033; 51.562identity in 320 aa overlap; NAD dependent epimerase 1510853 wbtF 3192079 wbtF Francisella tularensis subsp. tularensis SCHU S4 NAD dependent epimerase YP_170396.1 1509882 R 177416 CDS YP_170397.1 56708501 3192081 complement(1510853..1512163) 1 NC_006570.2 Similar to Q8EMC3 Vi polysaccharide biosynthesis from Oceanobacillus iheyensis (437 aa). FASTA: opt: 1817 Z-score: 2048.6 E(): 2.9e-106 Smith-Waterman score: 1817; 59.268 identity in 437 aa overlap; UDP-glucose/GDP-mannose dehydrogenase 1512163 wbtE 3192081 wbtE Francisella tularensis subsp. tularensis SCHU S4 UDP-glucose/GDP-mannose dehydrogenase YP_170397.1 1510853 R 177416 CDS YP_170398.1 56708502 3192078 complement(1512181..1513272) 1 NC_006570.2 Similar to Q8EMF7 Galacturonosyl transferase from Oceanobacillus iheyensis (362 aa). FASTA: opt: 908 Z-score: 1050.2 E(): 1.2e-50 Smith-Waterman score: 908; 40.223 identity in 358 aa overlap; galacturonosyl transferase 1513272 wbtD 3192078 wbtD Francisella tularensis subsp. tularensis SCHU S4 galacturonosyl transferase YP_170398.1 1512181 R 177416 CDS YP_170399.1 56708503 3191944 complement(1513262..1514053) 1 NC_006570.2 Similar to Q9K6L4 UDP-glucose 4-epimerase from Bacillus halodurans (282 aa). FASTA: opt: 758 Z-score: 904.3 E(): 1.6e-42 Smith-Waterman score: 758; 45.455 identity in 264 aa overlap; UDP-glucose 4-epimerase 1514053 wbtC 3191944 wbtC Francisella tularensis subsp. tularensis SCHU S4 UDP-glucose 4-epimerase YP_170399.1 1513262 R 177416 CDS YP_170400.1 56708504 3191948 complement(1514055..1514672) 1 NC_006570.2 Similarity to Q9K6L3 Galactosyltransferase from Bacillus halodurans (207 aa). FASTA: opt: 902 Z-score: 1122.0 E(): 1.2e-54 Smith-Waterman score: 902; 66.667 identity in 195 aa overlap; galactosyl transferase 1514672 wbtB 3191948 wbtB Francisella tularensis subsp. tularensis SCHU S4 galactosyl transferase YP_170400.1 1514055 R 177416 CDS YP_170401.1 56708505 3191939 complement(1514680..1516416) 1 NC_006570.2 Similar to Q9S4V4 PglF from Campylobacter jejuni (590 aa). FASTA: opt: 1343 Z-score: 1435.9 E(): 3.9e-72 Smith-Waterman score: 1378; 43.543identity in 604 aa overlap; dTDP-glucose 4,6-dehydratase 1516416 wbtA 3191939 wbtA Francisella tularensis subsp. tularensis SCHU S4 dTDP-glucose 4,6-dehydratase YP_170401.1 1514680 R 177416 CDS YP_170402.1 56708506 3190875 complement(1516518..1517261) 1 NC_006570.2 ISFtu2. Transposase, member of the IS5 family. Identical to Q8GM03 transposase from Francisella tularensis (247 aa).; transposase 1517261 isftu2 3190875 isftu2 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170402.1 1516518 R 177416 CDS YP_170403.1 56708507 3192075 complement(1518366..1519853) 1 NC_006570.2 Similar to Q8XQG4 L-aspartate oxidase 2 from Ralstonia solanacearum (536 aa). FASTA: opt: 1043 Z-score: 1161.3 E(): 7.8e-57 Smith-Waterman score: 1043; 38.008 identity in 492 aa overlap; L-aspartate oxidase 1519853 nadB 3192075 nadB Francisella tularensis subsp. tularensis SCHU S4 L-aspartate oxidase YP_170403.1 1518366 R 177416 CDS YP_170404.1 56708508 3190900 complement(1519856..1520719) 1 NC_006570.2 Similar to Q8DC25 Nicotinate-nucleotide pyrophosphorylase from Vibrio vulnificus (295 aa). FASTA: opt: 888 Z-score: 999.5 E(): 8e-48 Smith-Waterman score: 888; 53.737 identity in 281 aa overlap; nicotinate-nucleotide pyrophosphorylase 1520719 nadC 3190900 nadC Francisella tularensis subsp. tularensis SCHU S4 nicotinate-nucleotide pyrophosphorylase YP_170404.1 1519856 R 177416 CDS YP_170405.1 56708509 3192072 complement(1520728..1521753) 1 NC_006570.2 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 1521753 nadA 3192072 nadA Francisella tularensis subsp. tularensis SCHU S4 quinolinate synthetase YP_170405.1 1520728 R 177416 CDS YP_170406.1 56708510 3192552 complement(1521774..1522346) 1 NC_006570.2 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1522346 gmk 3192552 gmk Francisella tularensis subsp. tularensis SCHU S4 guanylate kinase YP_170406.1 1521774 R 177416 CDS YP_170407.1 56708511 3191508 complement(1522463..1524172) 1 NC_006570.2 Similar to DEAD_KLEPN (P33906) Cold-shock DEAD-box protein A (ATP-dependent RNA helicase deaD) from Klebsiella pneumoniae (642 aa). FASTA: opt: 1669 Z-score: 1759.9 E(): 3.5e-90 Smith-Waterman score: 1669; 45.070 identity in 568 aa overlap; cold-shock DEAD-box protein A 1524172 deaD 3191508 deaD Francisella tularensis subsp. tularensis SCHU S4 cold-shock DEAD-box protein A YP_170407.1 1522463 R 177416 CDS YP_170408.1 56708512 3192184 complement(1524237..1524515) 1 NC_006570.2 Identical to Q9ETL6 parvulin ( peptidyl-prolyl cis-trans isomerase) from Francisella tularensis ssp. tularensis strain SchuS4 (FSC237) (92 aa).; peptidyl-prolyl cis-trans isomerase 1524515 ppiC 3192184 ppiC Francisella tularensis subsp. tularensis SCHU S4 peptidyl-prolyl cis-trans isomerase YP_170408.1 1524237 R 177416 CDS YP_170409.1 56708513 3191585 complement(1524610..1526004) 1 NC_006570.2 Similar to GALP__ECOLI Galactose-proton symporter from E. coli (464 aa). FASTA: opt: 965 Z-score: 1103.1 E(): 1.4e-53 Smith-Waterman score: 965; 36.226 identity in 461 aa overlap; major facilitator superfamily galactose-proton symporter 1526004 galP2 3191585 galP2 Francisella tularensis subsp. tularensis SCHU S4 major facilitator superfamily galactose-proton symporter YP_170409.1 1524610 R 177416 CDS YP_170410.1 56708514 3191546 complement(1526036..1527418) 1 NC_006570.2 Similar to AAO70555 (Q8XEV6) Galactose-proton symport from Salmonella typhimurium (464 aa). FASTA: opt: 1295 Z-score: 1483.7 E(): 8.6e-75 Smith-Waterman score: 1295; 45.140 identity in 463 aa overlap; major facilitator superfamily galactose-proton symporter 1527418 galP1 3191546 galP1 Francisella tularensis subsp. tularensis SCHU S4 major facilitator superfamily galactose-proton symporter YP_170410.1 1526036 R 177416 CDS YP_170411.1 56708515 3192373 1527509..1528534 1 NC_006570.2 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 1528534 galT 3192373 galT Francisella tularensis subsp. tularensis SCHU S4 galactose-1-phosphate uridylyltransferase YP_170411.1 1527509 D 177416 CDS YP_170412.1 56708516 3191539 1528537..1529685 1 NC_006570.2 Similar to GAL1_ACTPL Galactokinase from Actinobacillus pleuropneumoniae (384 aa) FASTA: opt: 959 Z-score: 1098.0 E(): 2.6e-53 Smith-Waterman score: 959; 38.710identity in 372 aa overlap; galactokinase 1529685 galK 3191539 galK Francisella tularensis subsp. tularensis SCHU S4 galactokinase YP_170412.1 1528537 D 177416 CDS YP_170413.1 56708517 3191765 complement(1529682..1530077) 1 NC_006570.2 Similar to Q88NK0 Conserved hypothetical protein from Pseudomonas putida (139 aa). FASTA: opt: 362 Z-score: 463.4 E(): 5.9e-18 Smith-Waterman score: 362; 40.458 identity in 131 aa overlap ORF ftt1477c; hypothetical protein 1530077 3191765 FTT_1477c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170413.1 1529682 R 177416 CDS YP_170414.2 255961464 3192251 complement(1530070..1530822) 1 NC_006570.2 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1530822 kdsB 3192251 kdsB Francisella tularensis subsp. tularensis SCHU S4 3-deoxy-manno-octulosonate cytidylyltransferase YP_170414.2 1530070 R 177416 CDS YP_170415.1 56708519 3192303 complement(1530815..1531003) 1 NC_006570.2 Similarity to Q8DAV0 Conserved hypothetical protein from Vibrio vulnificus (59 aa). FASTA: opt: 252 Z-score: 369.5 E(): 1e-12 Smith-Waterman score: 252; 56.140 identity in 57 aa overlap ORF ftt1479c; hypothetical protein 1531003 3192303 FTT_1479c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170415.1 1530815 R 177416 CDS YP_170417.1 56708521 3191013 complement(join(1531728..1532186,1532186..1532512)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1532512 isftu1 3191013 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170417.1 1531728 R 177416 CDS YP_170418.1 56708522 3192301 complement(1532885..1534297) 1 NC_006570.2 Similar to AAO90013 (Q83E67) Dihydrolipoamide dehydrogenase from Coxiella burnetti (474 aa). FASTA: opt: 2052 Z-score: 2129.3 E(): 9.5e-111 Smith-Waterman score: 2052; 65.890 identity in 472 aa overlap.; dihydrolipoamide dehydrogenase 1534297 lpd 3192301 lpd Francisella tularensis subsp. tularensis SCHU S4 dihydrolipoamide dehydrogenase YP_170418.1 1532885 R 177416 CDS YP_170419.1 56708523 3192412 complement(1534311..1536206) 1 NC_006570.2 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 1536206 aceF 3192412 aceF Francisella tularensis subsp. tularensis SCHU S4 dihydrolipoamide acetyltransferase YP_170419.1 1534311 R 177416 CDS YP_170420.1 56708524 3192411 complement(1536224..1538905) 1 NC_006570.2 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 1538905 aceE 3192411 aceE Francisella tularensis subsp. tularensis SCHU S4 pyruvate dehydrogenase subunit E1 YP_170420.1 1536224 R 177416 CDS YP_170421.1 56708525 3190829 complement(1539205..1540341) 1 NC_006570.2 Similar to AAO91321 (Q83AQ3) Hypothetical protein from Coxiella burnetti (388 aa). FASTA: opt: 858 Z-score: 1007.0 E(): 3.1e-48 Smith-Waterman score: 858 38.504 identity in 361 aa overlap ORF ftt1486c; hypothetical protein 1540341 3190829 FTT_1486c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170421.1 1539205 R 177416 CDS YP_170422.1 56708526 3191932 1540469..1541083 1 NC_006570.2 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 1541083 coaE 3191932 coaE Francisella tularensis subsp. tularensis SCHU S4 dephospho-CoA kinase YP_170422.1 1540469 D 177416 CDS YP_170423.1 56708527 3190995 1541380..1542384 1 NC_006570.2 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 1542384 trpS 3190995 trpS Francisella tularensis subsp. tularensis SCHU S4 tryptophanyl-tRNA synthetase YP_170423.1 1541380 D 177416 CDS YP_170424.1 56708528 3190835 1542386..1543111 1 NC_006570.2 ORF ftt1489; hypothetical protein 1543111 3190835 FTT_1489 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170424.1 1542386 D 177416 CDS YP_170425.1 56708529 3192492 1543121..1544419 1 NC_006570.2 Similar to Q9RZK7 NA+/H+ antiporter, , from Deinococcus radiodurans (422 aa). FASTA: opt: 529 Z-score: 612.1 E(): 3.1e-26 Smith-Waterman score: 771; 36.211 identity in 417 aa overlap ORF ftt1490; Na+/H+ antiporter 1544419 3192492 FTT_1490 Francisella tularensis subsp. tularensis SCHU S4 Na+/H+ antiporter YP_170425.1 1543121 D 177416 CDS YP_170428.1 56708532 3191764 complement(1546344..1546739) 1 NC_006570.2 ORF ftt1493c; hypothetical protein 1546739 3191764 FTT_1493c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170428.1 1546344 R 177416 CDS YP_170429.1 56708533 3192311 complement(1546741..1547625) 1 NC_006570.2 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 1547625 murQ 3192311 murQ Francisella tularensis subsp. tularensis SCHU S4 N-acetylmuramic acid 6-phosphate etherase YP_170429.1 1546741 R 177416 CDS YP_170430.1 56708534 3192314 complement(1547622..1549586) 1 NC_006570.2 ORF ftt1495c; hypothetical protein 1549586 3192314 FTT_1495c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170430.1 1547622 R 177416 CDS YP_170431.1 56708535 3190823 complement(1549595..1550608) 1 NC_006570.2 ORF ftt1496c; hypothetical protein 1550608 3190823 FTT_1496c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170431.1 1549595 R 177416 CDS YP_170432.1 56708536 3192312 complement(1550589..1551092) 1 NC_006570.2 ORF ftt1497c; hypothetical protein 1551092 3192312 FTT_1497c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170432.1 1550589 R 177416 CDS YP_170433.1 56708537 3192200 complement(1551112..1552059) 1 NC_006570.2 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-Coa carboxylase carboxyltransferase subunit alpha 1552059 accA 3192200 accA Francisella tularensis subsp. tularensis SCHU S4 acetyl-Coa carboxylase carboxyltransferase subunit alpha YP_170433.1 1551112 R 177416 CDS YP_170434.1 56708538 3192057 1552193..1554766 1 NC_006570.2 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 1554766 muts 3192057 muts Francisella tularensis subsp. tularensis SCHU S4 DNA mismatch repair protein MutS YP_170434.1 1552193 D 177416 CDS YP_170435.1 56708539 3191901 1554838..1555281 1 NC_006570.2 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 1555281 secB2 3191901 secB2 Francisella tularensis subsp. tularensis SCHU S4 preprotein translocase subunit SecB YP_170435.1 1554838 D 177416 CDS YP_170436.1 56708540 3190878 1556722..1557939 1 NC_006570.2 Similar to AAP17334 (TRYP_ECOLI) Tyrosine-specific transport protein from E. coli (403 aa). FASTA: opt: 741 Z-score: 839.5 E(): 6.5e-39 Smith-Waterman score: 741; 32.663identity in 398 aa overlap ORF ftt1502; aromatic amino acid HAAP transporter 1557939 3190878 FTT_1502 Francisella tularensis subsp. tularensis SCHU S4 aromatic amino acid HAAP transporter YP_170436.1 1556722 D 177416 CDS YP_170437.1 56708541 3191568 1557949..1558827 1 NC_006570.2 Similar to Q88B11 Integrase/recombinase XerC from Pseudomonas syringae (295 aa). FASTA: opt: 790 Z-score: 939.6 E(): 1.7e-44 Smith-Waterman score: 790; 42.177 identity in 294 aa overlap.; integrase/recombinase XerC 1558827 xerC 3191568 xerC Francisella tularensis subsp. tularensis SCHU S4 integrase/recombinase XerC YP_170437.1 1557949 D 177416 CDS YP_170438.1 56708542 3192496 1558827..1559552 1 NC_006570.2 Similar to YHIQ_NEIGO P72077 Hypothetical 27.3kDa protein from Neisseria gonorrhoeae (254 aa). FASTA: opt: 350 Z-score: 423.8 E(): 9.3e-16 Smith-Waterman score: 350; 36.073 identity in 219 aa overlap. ORF ftt1504; hypothetical protein 1559552 3192496 FTT_1504 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170438.1 1558827 D 177416 CDS YP_170439.1 56708543 3190866 complement(1559559..1560173) 1 NC_006570.2 ORF ftt1505c; hypothetical protein 1560173 3190866 FTT_1505c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170439.1 1559559 R 177416 CDS YP_170440.1 56708544 3190870 1560261..1560839 1 NC_006570.2 ORF ftt1506; hypothetical protein 1560839 3190870 FTT_1506 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170440.1 1560261 D 177416 CDS YP_170441.1 56708545 3192309 1560916..1561548 1 NC_006570.2 ORF ftt1507; hypothetical protein 1561548 3192309 FTT_1507 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170441.1 1560916 D 177416 CDS YP_170442.1 56708546 3191632 complement(1561664..1563607) 1 NC_006570.2 Similar to Q8EBQ4 GTP pyrophosphokinase from Shewenella oneidensis (735 aa). FASTA: opt: 1566 Z-score: 1723.7 E(): 3.7e-88 Smith-Waterman score: 1639; 39.744 identity in 624 aa overlap; GTP pyrophosphokinase 1563607 relA 3191632 relA Francisella tularensis subsp. tularensis SCHU S4 GTP pyrophosphokinase YP_170442.1 1561664 R 177416 CDS YP_170443.1 56708547 3190812 complement(1563976..1564332) 1 NC_006570.2 ORF ftt1509c; hypothetical protein 1564332 3190812 FTT_1509c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170443.1 1563976 R 177416 CDS YP_170444.1 56708548 3191763 complement(1564366..1565562) 1 NC_006570.2 Similar to Q8DAB5 Tyrosine-specific transport protein from Vibrio vulnificus (401 aa). FASTA: opt: 804 Z-score: 930.6 E(): 5.5e-44 Smith-Waterman score: 804; 35.309 identity in 405 aa overlap ORF ftt1510; aromatic amino acid HAAP transporter 1565562 3191763 FTT_1510c Francisella tularensis subsp. tularensis SCHU S4 aromatic amino acid HAAP transporter YP_170444.1 1564366 R 177416 CDS YP_170445.1 56708549 3190797 1565753..1566637 1 NC_006570.2 Similar to AAO90839 Membrane protein, from Coxiella burnetii (305 aa). FASTA: opt: 693 Z-score: 824.9 E(): 4.3e-38 Smith-Waterman score: 693; 38.776 identity in 294 aa overlap. ORF ftt1511; hypothetical protein 1566637 3190797 FTT_1511 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170445.1 1565753 D 177416 CDS YP_170446.1 56708550 3191530 complement(1566627..1567553) 1 NC_006570.2 Similar to CAD85066 (Q82VD9) DnaJ N-terminal domain:DnaJ C terminal domain from Nitrosomonas europaea (314 aa). FASTA opt: 800 Z-score: 823.9 E(): 4.8e-38 39.482 identity in 309 aa overlap.; heat shock protein, hsp40 1567553 dnaJ2 3191530 dnaJ2 Francisella tularensis subsp. tularensis SCHU S4 heat shock protein, hsp40 YP_170446.1 1566627 R 177416 CDS YP_170447.1 56708551 3192319 complement(1568483..1568854) 1 NC_006570.2 ORF ftt1514c; hypothetical protein 1568854 3192319 FTT_1514c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170447.1 1568483 R 177416 CDS YP_170448.1 56708552 3192482 complement(1568862..1569461) 1 NC_006570.2 Similar to Q8XMV7 Hypothetical protein CPE0581 from Clostridium perfrigens (195 aa). FASTA: opt: 348 Z-score: 432.5 E(): 3.1e-16 Smith-Waterman score: 348; 33.333 identity in 189 aa overlap. FTT1563 is more likely to be phosphatidylcoline synthase. ORF ftt1515c; hypothetical protein 1569461 3192482 FTT_1515c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170448.1 1568862 R 177416 CDS YP_170449.1 56708553 3190872 complement(1570879..1571598) 1 NC_006570.2 Similar to Q92KR0 hypothetical transmembrane protein from Rhizobium meliloti (266aa). FASTA: opt: 566 Z-score: 664.8 E(): 3.5e-29 Smith-Waterman score: 566; 40.090 identity in 222 aa overlap. ORF ftt1517c; hypothetical protein 1571598 3190872 FTT_1517c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170449.1 1570879 R 177416 CDS YP_170450.1 56708554 3191050 1571628..1572200 1 NC_006570.2 Similar to Q8A7W3 methylated-DNA--protein-cysteine methyltransferase from Bacteroides thetaiotaomicron (181aa). FASTA: opt: 443 Z-score: 536.8 bits: 106.7 E(): 4.8e-22 Smith-Waterman score: 443; 44.375 identity in 160 aa overlap. ogt in E.coli is a bifunctional protein containing an autotranscriptional activator at its carboxy domain and a methylated-DNA--protein-cysteine methyltransferase (MGMT) domain at its carboxy terminus. In Bacillus subtilis these two functions are independent and are referred to as adaA and adaB respectively; methylated-DNA--protein-cysteine methyltransferase 1572200 ogt 3191050 ogt Francisella tularensis subsp. tularensis SCHU S4 methylated-DNA--protein-cysteine methyltransferase YP_170450.1 1571628 D 177416 CDS YP_170451.1 56708555 3191571 complement(1572684..1574021) 1 NC_006570.2 Similar to Q8A4M6 glutamate/gamma-aminobutyrate anti-porter from Bacteroides thetaiotaomicron. FASTA: opt: 911 Z-score: 1001.3 E(): 6.4e-48 Smith-Waterman score: 911; 31.696identity in 448 aa overlap.; glutamate/gamma-aminobutyrate anti-porter 1574021 gabP 3191571 gabP Francisella tularensis subsp. tularensis SCHU S4 glutamate/gamma-aminobutyrate anti-porter YP_170451.1 1572684 R 177416 CDS YP_170452.1 56708556 3191012 complement(1575272..1575862) 1 NC_006570.2 Similar to Q8P4A2, hypothetical protein XCC3808 from Xanthamonas campestris (258aa). FASTA: opt:421 Z-score: 521.1 E(): 3.6e-21 Smith-Waterman score: 421; 34.536 identity in 194 aa overlap ORF ftt1522c; hypothetical protein 1575862 3191012 FTT_1522c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170452.1 1575272 R 177416 CDS YP_170453.1 56708557 3192477 complement(1576231..1576974) 1 NC_006570.2 ISFtu2. Transposase, member of the IS5 family. Identical to Q8GM03 transposase from Francisella tularensis (247 aa).; transposase 1576974 isftu2 3192477 isftu2 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170453.1 1576231 R 177416 CDS YP_170454.1 56708558 3192408 complement(1577456..1581724) 1 NC_006570.2 Similar to Q8ZE61 ATP-dependent helicase from Yersinia pestis (1280 aa). FASTA: opt: 2018 Z-score: 2071.8 E(): 1.5e-107 Smith-Waterman score: 2974; 38.714 identity in 1400 aa overlap; ATp-dependent helicase 1581724 hrpA 3192408 hrpA Francisella tularensis subsp. tularensis SCHU S4 ATp-dependent helicase YP_170454.1 1577456 R 177416 CDS YP_170455.1 56708559 3190818 complement(1581748..1582635) 1 NC_006570.2 ORF ftt1525c; hypothetical protein 1582635 3190818 FTT_1525c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170455.1 1581748 R 177416 CDS YP_170456.1 56708560 3192248 complement(1582649..1584892) 1 NC_006570.2 Similar to Q8EDW2 Isocitrate dehydrogenase,NADP-dependent from Shewanella oneidensis (741 aa). FASTA: opt: 3146 Z-score: 3332.9 E(): 8.6e-178 65.574identity in 732 aa overlap; isocitrate dehydrogenase 1584892 idh 3192248 idh Francisella tularensis subsp. tularensis SCHU S4 isocitrate dehydrogenase YP_170456.1 1582649 R 177416 CDS YP_170457.1 56708561 3191783 complement(1584896..1585261) 1 NC_006570.2 Similar to Q87MH6 Arsenate reductase from Vibrio parahaemolyticus (116 aa). FASTA: opt: 287 Z-score: 374.9 E(): 5e-13 Smith-Waterman score: 287; 38.739 identity in 111 aa overlap; arsenate reductase 1585261 arsC2 3191783 arsC2 Francisella tularensis subsp. tularensis SCHU S4 arsenate reductase YP_170457.1 1584896 R 177416 CDS YP_170458.1 56708562 3191875 1585477..1587165 1 NC_006570.2 Similar to Q8EE09 Long-chain-fatty-acid--CoA ligase from Shewanella oneidensis (557 aa). FASTA: opt: 1556 Z-score: 1747.3 E(): 1.8e-89 Smith-Waterman score: 1556; 42.908identity in 557 aa overlap; long chain fatty acid CoA ligase 1587165 fadD2 3191875 fadD2 Francisella tularensis subsp. tularensis SCHU S4 long chain fatty acid CoA ligase YP_170458.1 1585477 D 177416 CDS YP_170459.3 255961465 3191873 1587182..1589443 1 NC_006570.2 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 1589443 fadE 3191873 fadE Francisella tularensis subsp. tularensis SCHU S4 acyl-CoA dehydrogenase YP_170459.3 1587182 D 177416 CDS YP_170460.1 56708564 3191871 1589516..1592212 1 NC_006570.2 N-terminal (85 aa) similar to CBP_YEAST (P31787) Acyl-CoA-binding protein (ACBP) from Saccharomyces cerevisiae (86 aa). FASTA opt: 206 Z-score: 281.8 E(): 7.6e-08 Smith-Waterman score: 206; 44.444identity in 72 aa overlap. C-terminus (110-898) similar to Q8P986 3-hydroxacyl-CoA dehydrogenase from Xanthomonas campestris (790 aa). FASTA: opt: 2495 Z-score: 2747.5 E(): 3.5e-145 Smith-Waterman score: 2495;48.228 identity in 790 aa overlap No match to first 110 aa with Q8P986 or any other 3-hydroxacyl-CoA dehydrogenase. Acyl-CoA-binding protein has only been described in eukaryotes unknown EC_number 5.2.2.3; bifunctional 3-hydroxacyl-CoA dehydrogenase/acyl-CoA-binding protein 1592212 fadB/acbP 3191871 fadB/acbP Francisella tularensis subsp. tularensis SCHU S4 bifunctional 3-hydroxacyl-CoA dehydrogenase/acyl-CoA-binding protein YP_170460.1 1589516 D 177416 CDS YP_170461.1 56708565 3191866 1592225..1593412 1 NC_006570.2 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 1593412 fadA 3191866 fadA Francisella tularensis subsp. tularensis SCHU S4 acetyl-CoA acetyltransferase YP_170461.1 1592225 D 177416 CDS YP_170462.1 56708566 3190857 1593474..1593962 1 NC_006570.2 Similar to Q8ABB1 Conserved hypothetical protein from Bacteriodes thetaiotaomicron (163 aa). FASTA: opt: 237 Z-score: 310.7 E(): 1.9e-09 Smith-Waterman score: 237; 27.097 identity in 155 aa overlap ORF ftt1532; hypothetical protein 1593962 3190857 FTT_1532 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170462.1 1593474 D 177416 CDS YP_170463.1 56708567 3190863 complement(1595622..1597037) 1 NC_006570.2 Similar to Q8P596 Pre-B cell enhancing factor related protein from Xanthomonas campestris (468 aa). FASTA: opt: 1453 Z-score: 1660.8 E(): 1.2e-84 Smith-Waterman score: 1453; 49.260 identity in 473 aa overlap ORF ftt1534c; nicotinate phosphoribosyltransferase 1597037 3190863 FTT_1534c Francisella tularensis subsp. tularensis SCHU S4 nicotinate phosphoribosyltransferase YP_170463.1 1595622 R 177416 CDS YP_170464.1 56708568 3192292 complement(1598380..1599294) 1 NC_006570.2 Similar to Q8RGP8 Hypothetical protein from Mycoplasma penetrans (310 aa). FASTA: opt: 805 Z-score: 956.1 E(): 2.1e-45 Smith-Waterman score: 805; 42.308 identity in 312 aa overlap ORF ftt1536c; hypothetical protein 1599294 3192292 FTT_1536c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170464.1 1598380 R 177416 CDS YP_170465.1 56708569 3192317 complement(1599434..1600828) 1 NC_006570.2 Similar to Q8DAW7 Conserved hypothetical protein from Vibrio vulnificus (448 aa). FASTA: opt: 455 Z-score: 511.9 E(): 1.2e-20 Smith-Waterman score: 520; 26.539 identity in 471 aa overlap ORF ftt1537c; hypothetical protein 1600828 3192317 FTT_1537c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170465.1 1599434 R 177416 CDS YP_170466.1 56708570 3192498 complement(1600834..1601817) 1 NC_006570.2 ORF ftt1538c; hypothetical protein 1601817 3192498 FTT_1538c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170466.1 1600834 R 177416 CDS YP_170467.1 56708571 3190869 complement(1601828..1603258) 1 NC_006570.2 Similar to Q9PJ34 periplasmic protein from Campylobacter jejuni (445 aa). FASTA: opt: 520 Z-score: 539.8 E(): 3.2e-22 Smith-Waterman score: 530; 27.673 identity in 477 aa overlap ORF ftt1539c; hypothetical protein 1603258 3190869 FTT_1539c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170467.1 1601828 R 177416 CDS YP_170468.1 56708572 3192320 complement(1603315..1603923) 1 NC_006570.2 Similar to Q8EHZ4 Conserved hypothetical protein from Shewanella oneidensis (197 aa). FASTA: opt: 542 Z-score: 654.0 E(): 1.4e-28 Smith-Waterman score: 542; 41.584 identity in 202 aa overlap ORF ftt1540c; hypothetical protein 1603923 3192320 FTT_1540c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170468.1 1603315 R 177416 CDS YP_170470.1 56708574 3191140 complement(1604618..1605154) 1 NC_006570.2 Similar to Q57483 Outer membrane protein 26 precursor (197 aa). FASTA: opt: 139 Z-score: 159.9 E(): 0.47 Smith-Waterman score: 139; 25.641 identity in 195 aa overlap; hypothetical protein 1605154 omp26 3191140 omp26 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170470.1 1604618 R 177416 CDS YP_170471.1 56708575 3190991 1605297..1605986 1 NC_006570.2 Similar to Q8UGQ7 Two component response regulator from Agrobacterium tumefaciens (252 aa). FASTA: opt: 684 Z-score: 819.7 E(): 8.4e-38 Smith-Waterman score: 684; 45.333 identity in 225 aa overlap ORF ftt1543; two component response regulator 1605986 3190991 FTT_1543 Francisella tularensis subsp. tularensis SCHU S4 two component response regulator YP_170471.1 1605297 D 177416 CDS YP_170472.1 56708576 3190830 join(1609794..1610120,1610120..1610578) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1610578 isftu1 3190830 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170472.1 1609794 D 177416 CDS YP_170473.1 56708577 3192255 1611289..1611744 1 NC_006570.2 ORF ftt1549; hypothetical protein 1611744 3192255 FTT_1549 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170473.1 1611289 D 177416 CDS YP_170474.1 56708578 3192230 1611838..1612380 1 NC_006570.2 Similar to Q8EBW9 Conserved hypothetical protein (183 aa). FASTA: opt: 505 Z-score: 618.4 E(): 1.4e-26 Smith-Waterman score: 505; 40.237identity in 169 aa overlap ORF ftt1550; hypothetical protein 1612380 3192230 FTT_1550 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170474.1 1611838 D 177416 CDS YP_170475.1 56708579 3192231 1612382..1613125 1 NC_006570.2 Similar to Q888B1 Oxidoreductase,short chain dehydrogenase from Pseudomonas syringae (262 aa). FASTA: opt: 390 Z-score: 468.5 E(): 3e-18 Smith-Waterman score: 445; 32.143 identity in 252 aa overlap ORF ftt1551; oxidoreductase 1613125 3192231 FTT_1551 Francisella tularensis subsp. tularensis SCHU S4 oxidoreductase YP_170475.1 1612382 D 177416 CDS YP_170476.1 56708580 3191051 1613139..1613966 1 NC_006570.2 Similar to Q8PMP8 Delta 9 acyl-lipid fatty acid desaturase from Xanthomonas axonopodis (298 aa). FASTA: opt: 851 Z-score: 1027.5 E(): 2.2e-49 Smith-Waterman score: 851; 45.149identity in 268 aa overlap; Delta 9 acyl-lipid fatty acid desaturase 1613966 ole1 3191051 ole1 Francisella tularensis subsp. tularensis SCHU S4 Delta 9 acyl-lipid fatty acid desaturase YP_170476.1 1613139 D 177416 CDS YP_170477.1 56708581 3191067 complement(1613990..1616287) 1 NC_006570.2 Similar to Q8EAG7 Ribonuclease R from (808 aa). FASTA: opt: 1840 Z-score: 1989.4 E(): 5.9e-103 Smith-Waterman score: 1863; 41.602 identity in 774 aa overlap; ribonuclease R 1616287 rnr 3191067 rnr Francisella tularensis subsp. tularensis SCHU S4 ribonuclease R YP_170477.1 1613990 R 177416 CDS YP_170478.1 56708582 3190994 complement(1616280..1617188) 1 NC_006570.2 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1617188 truB 3190994 truB Francisella tularensis subsp. tularensis SCHU S4 tRNA pseudouridine synthase B YP_170478.1 1616280 R 177416 CDS YP_170479.1 56708583 3191612 complement(1617175..1617867) 1 NC_006570.2 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 1617867 rnc 3191612 rnc Francisella tularensis subsp. tularensis SCHU S4 ribonuclease III YP_170479.1 1617175 R 177416 CDS YP_170480.1 56708584 3190721 complement(1617874..1618737) 1 NC_006570.2 Similar to AAO90612 9 83CL5) Signal peptidase I from Coxiella burnetii (259 aa). FASTA: opt: 716 Z-score: 839.6 E(): 6.5e-39 Smith-Waterman score: 717; 39.416 identity in 274 aa overlap; signal peptidase I 1618737 lepB 3190721 lepB Francisella tularensis subsp. tularensis SCHU S4 signal peptidase I YP_170480.1 1617874 R 177416 CDS YP_170481.1 56708585 3190787 complement(1618742..1619428) 1 NC_006570.2 Similar to AAO90736 DNA-binding response regulator from Coxiella burnetii (223 aa). FASTA: opt: 669 Z-score: 771.7 E(): 3.9e-35 Smith-Waterman score: 669; 45.778 identity in 225 aa overlap ORF ftt1557c; two-component response regulator 1619428 3190787 FTT_1557c Francisella tularensis subsp. tularensis SCHU S4 two-component response regulator YP_170481.1 1618742 R 177416 CDS YP_170482.1 56708586 3191232 complement(1621205..1622029) 1 NC_006570.2 Similar to Q87LJ5 Pyrroline-5-carboxylate reductase from Vibrio parahaemolyticus (272 aa). FASTA: opt: 656 Z-score: 770.0 E(): 4.9e-35 Smith-Waterman score: 656; 39.925identity in 268 aa overlap; pyrroline-5-carboxylate reductase 1622029 proC 3191232 proC Francisella tularensis subsp. tularensis SCHU S4 pyrroline-5-carboxylate reductase YP_170482.1 1621205 R 177416 CDS YP_170483.1 56708587 3190748 1622136..1622714 1 NC_006570.2 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 1622714 3190748 FTT_1560 Francisella tularensis subsp. tularensis SCHU S4 deoxyribonucleotide triphosphate pyrophosphatase YP_170483.1 1622136 D 177416 CDS YP_170484.1 56708588 3191532 1622819..1624114 1 NC_006570.2 Similar to Q87VF9 3-deoxy-D-manno-octulosonic-acid transferase from Pseudomonas syringae (447 aa). FASTA: opt: 1099 Z-score: 1251.3 E(): 7.6e-62 Smith-Waterman score: 1099; 40.143 identity in 421 aa overlap; 3-deoxy-D-manno-octulosonic-acid transferase 1624114 kdtA 3191532 kdtA Francisella tularensis subsp. tularensis SCHU S4 3-deoxy-D-manno-octulosonic-acid transferase YP_170484.1 1622819 D 177416 CDS YP_170485.1 56708589 3192308 1624111..1624992 1 NC_006570.2 Similar to P45204 Geranyltranstransferase from Haemophilus influenzae (295 aa). FASTA: opt: 728 Z-score: 859.4 E(): 5.1e-40 Smith-Waterman score: 728; 43.972 identity in 282 aa overlap; geranyltranstransferase 1624992 ispA 3192308 ispA Francisella tularensis subsp. tularensis SCHU S4 geranyltranstransferase YP_170485.1 1624111 D 177416 CDS YP_170486.1 56708590 3191290 1625040..1625804 1 NC_006570.2 Similar to O51265 Phosphatidyltransferase from Borrelia burgdorferi (234 aa). FASTA: opt: 438 Z-score: 531.7 E(): 9.1e-22 Smith-Waterman score: 496; 35.743 identity in 249 aa overlap; phosphatidylcholine synthase 1625804 pcs 3191290 pcs Francisella tularensis subsp. tularensis SCHU S4 phosphatidylcholine synthase YP_170486.1 1625040 D 177416 CDS YP_170487.1 56708591 3190758 1625874..1626683 1 NC_006570.2 Similar to Q9I6Z1 Hypothetical protein PA0141 from Pseudomonas aeruginosa (298 aa). FASTA: opt: 1210 Z-score: 1427.9 E(): 1.1e-71 Smith-Waterman score: 1210; 62.738 identity in 263 aa overlap ORF ftt1564; hypothetical protein 1626683 3190758 FTT_1564 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170487.1 1625874 D 177416 CDS YP_170489.1 56708593 3192158 complement(1628971..1629558) 1 NC_006570.2 ORF ftt1567c; hypothetical protein 1629558 3192158 FTT_1567c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170489.1 1628971 R 177416 CDS YP_170490.1 56708594 3191793 complement(1629617..1630759) 1 NC_006570.2 Similar to Q87MF0 Lipid-A-disaccharide synthase from Vibrio parahaemolyticus (379 aa). FASTA: 603 opt: 1010 Z-score: 1166.5 E(): 4e-57 Smith-Waterman score: 1010; 41.207 identity in 381 aa overlap; lipid-A-disaccharide synthase 1630759 lpxB 3191793 lpxB Francisella tularensis subsp. tularensis SCHU S4 lipid-A-disaccharide synthase YP_170490.1 1629617 R 177416 CDS YP_170491.1 56708595 3190814 complement(1630759..1631538) 1 NC_006570.2 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 1631538 lpxA 3190814 lpxA Francisella tularensis subsp. tularensis SCHU S4 UDP-N-acetylglucosamine acyltransferase YP_170491.1 1630759 R 177416 CDS YP_170492.1 56708596 3191868 complement(1631541..1632032) 1 NC_006570.2 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 1632032 fabZ 3191868 fabZ Francisella tularensis subsp. tularensis SCHU S4 (3R)-hydroxymyristoyl-ACP dehydratase YP_170492.1 1631541 R 177416 CDS YP_170493.1 56708597 3190807 complement(1632047..1633060) 1 NC_006570.2 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 1633060 lpxD 3190807 lpxD Francisella tularensis subsp. tularensis SCHU S4 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_170493.1 1632047 R 177416 CDS YP_170494.1 56708598 3191143 complement(1633079..1633582) 1 NC_006570.2 Similar to OMPH_YEREN Cationic 19 kDa outer membrane protein from Yersinia enterocolitica (169 aa). FASTA: opt: 245 Z-score: 251.8 E(): 3.6e-06 Smith-Waterman score: 245; 28.000 identity in 150 aa overlap; outer membrane protein OmpH 1633582 ompH 3191143 ompH Francisella tularensis subsp. tularensis SCHU S4 outer membrane protein OmpH YP_170494.1 1633079 R 177416 CDS YP_170495.1 56708599 3192167 complement(1633718..1636096) 1 NC_006570.2 Similar to Q88MH2 Outer membrane protein,bacterial surface antigen family from Pseudomonas putida (786 aa). FASTA: opt: 1561 Z-score: 1675.2 E(): 1.9e-85 Smith-Waterman score: 1561; 32.959 identity in 801 aa overlap ORF ftt1573c; hypothetical protein 1636096 3192167 FTT_1573c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170495.1 1633718 R 177416 CDS YP_170496.1 56708600 3191554 complement(1636102..1637259) 1 NC_006570.2 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1637259 dxr 3191554 dxr Francisella tularensis subsp. tularensis SCHU S4 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_170496.1 1636102 R 177416 CDS YP_170497.1 56708601 3191786 complement(1637265..1639871) 1 NC_006570.2 Similar to GYRA_SALTY (P37411) DNA gyrase subunit A from Salmonella typhimurium (878 aa). FASTA: opt: 3442 Z-score: 3640.6 E(): 6.3e-195 Smith-Waterman score: 3442; 60.665 identity in 872 aa overlap; DNA gyrase subunit A 1639871 gyrA 3191786 gyrA Francisella tularensis subsp. tularensis SCHU S4 DNA gyrase subunit A YP_170497.1 1637265 R 177416 CDS YP_170498.1 56708602 3192137 1640130..1640675 1 NC_006570.2 ORF ftt1576; hypothetical protein 1640675 3192137 FTT_1576 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170498.1 1640130 D 177416 CDS YP_170499.1 56708603 3192144 1640711..1641796 1 NC_006570.2 ORF ftt1577; hypothetical protein 1641796 3192144 FTT_1577 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170499.1 1640711 D 177416 CDS YP_170500.1 56708604 3192316 complement(1641831..1642493) 1 NC_006570.2 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 1642493 ung 3192316 ung Francisella tularensis subsp. tularensis SCHU S4 uracil-DNA glycosylase YP_170500.1 1641831 R 177416 CDS YP_170501.1 56708605 3192096 complement(1642490..1645363) 1 NC_006570.2 Similar to O25314 Type III restriction enzyme R protein from Helicobacter pylori (1001 aa). FASTA: opt: 1491 Z-score: 1485.7 E(): 6.6e-75 Smith-Waterman score: 2480; 42.828 identity in 990 aa overlap ORF ftt1579c; Type III restriction enzyme 1645363 3192096 FTT_1579c Francisella tularensis subsp. tularensis SCHU S4 Type III restriction enzyme YP_170501.1 1642490 R 177416 CDS YP_170502.1 56708606 3192134 complement(1645600..1646130) 1 NC_006570.2 Identical to AAP83333 Hypothetical protein from Francisella tularensis ssp. tularensis strain SchuS4 (FSC237) (176 aa). ORF ftt1580c; hypothetical protein 1646130 3192134 FTT_1580c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170502.1 1645600 R 177416 CDS YP_170503.1 56708607 3192076 complement(1646199..1646483) 1 NC_006570.2 Similar to Q8DE33 Predicted endonuclease from Vibrio vulnificus (94 aa). FASTA: opt: 387 Z-score: 525.2 E(): 2.1e-21 Smith-Waterman score: 387; 61.798identity in 89 aa overlap ORF ftt1581c; endonuclease 1646483 3192076 FTT_1581c Francisella tularensis subsp. tularensis SCHU S4 endonuclease YP_170503.1 1646199 R 177416 CDS YP_170504.1 56708608 3190919 complement(join(1648839..1649297,1649297..1649623)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1649623 isftu1 3190919 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170504.1 1648839 R 177416 CDS YP_170506.1 56708610 3191930 complement(1649883..1650164) 1 NC_006570.2 ORF ftt1586c; hypothetical protein 1650164 3191930 FTT_1586c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170506.1 1649883 R 177416 CDS YP_008492916.1 537470119 3191942 complement(1650177..1651679) 1 NC_006570.2 hypothetical protein 1651679 3191942 FTT_1587c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_008492916.1 1650177 R 177416 CDS YP_170507.1 56708611 3191908 complement(1652045..1652788) 1 NC_006570.2 ORF ftt1589c; hypothetical protein 1652788 3191908 FTT_1589c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170507.1 1652045 R 177416 CDS YP_170508.1 56708612 3192481 complement(1652791..1653486) 1 NC_006570.2 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 1653486 ubiG 3192481 ubiG Francisella tularensis subsp. tularensis SCHU S4 3-demethylubiquinone-9 3-methyltransferase YP_170508.1 1652791 R 177416 CDS YP_170509.1 56708613 3191537 1653589..1654728 1 NC_006570.2 Similar to Q9Z674 Lipoprotein from Zymomonas mobilis (256 aa). FASTA: opt: 352 Z-score: 404.8 E(): 1.1e-14 Smith-Waterman score: 352; 31.739 identity in 230 aa overlap ORF ftt1591; lipoprotein 1654728 3191537 FTT_1591 Francisella tularensis subsp. tularensis SCHU S4 lipoprotein YP_170509.1 1653589 D 177416 CDS YP_170510.1 56708614 3191502 1658651..1659643 1 NC_006570.2 Similar to Q8D7C4 Transcriptional regulator from Vibrio vulnificus (301 aa). FASTA: opt: 364 Z-score: 428.7 E(): 5e-16 Smith-Waterman score: 364; 33.010 identity in 206 aa overlap ORF ftt1594; LysR family transcriptional regulator 1659643 3191502 FTT_1594 Francisella tularensis subsp. tularensis SCHU S4 LysR family transcriptional regulator YP_170510.1 1658651 D 177416 CDS YP_170513.1 56708617 3191501 1660677..1662134 1 NC_006570.2 ORF ftt1597; hypothetical protein 1662134 3191501 FTT_1597 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170513.1 1660677 D 177416 CDS YP_170514.1 56708618 3191599 1662198..1665032 1 NC_006570.2 This CDS is disrupted by the insertion of an ISFtu1 element occurring very near the C-terminal end. It is not clear whether this insertion affects the function of the protein. ORF ftt1598; hypothetical protein 1665032 3191599 FTT_1598 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170514.1 1662198 D 177416 CDS YP_170515.1 56708619 3191801 complement(join(1665129..1665587,1665587..1665913)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1665913 isftu1 3191801 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170515.1 1665129 R 177416 CDS YP_170516.1 56708620 3191534 complement(1666398..1667912) 1 NC_006570.2 Similar to Q87NJ5 Fumarate hydratase, class I from Vibrio parahaemolyticus (505 aa). FASTA: opt: 2398 Z-score: 2635.2 E(): 6.3e-139 Smith-Waterman score: 2398; 69.384 identity in 503 aa overlap; fumerate hydratase 1667912 fumA 3191534 fumA Francisella tularensis subsp. tularensis SCHU S4 fumerate hydratase YP_170516.1 1666398 R 177416 CDS YP_008492917.1 537470120 16744732 complement(1668466..1668663) 1 NC_006570.2 hypothetical protein 1668663 16744732 FTT_1600a Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_008492917.1 1668466 R 177416 CDS YP_170517.1 56708621 3191638 complement(1668667..1670706) 1 NC_006570.2 Similar to Q88C73 ATP-dependent DNA helicase RecG from Pseudomonas putida (692 aa). FASTA: opt: 1698 Z-score: 1867.5 E(): 3.6e-96 Smith-Waterman score: 1698; 41.314 identity in 685 aa overlap; ATP-dependent DNA helicase RecG 1670706 recG 3191638 recG Francisella tularensis subsp. tularensis SCHU S4 ATP-dependent DNA helicase RecG YP_170517.1 1668667 R 177416 CDS YP_170518.1 56708622 3191069 1670836..1671180 1 NC_006570.2 ORF ftt1602; hypothetical protein 1671180 3191069 FTT_1602 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170518.1 1670836 D 177416 CDS YP_170519.1 56708623 3191994 1671314..1671550 1 NC_006570.2 required for 70S ribosome assembly; 50S ribosomal protein L28 1671550 rpmB 3191994 rpmB Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L28 YP_170519.1 1671314 D 177416 CDS YP_170520.1 56708624 3191989 1671577..1671732 1 NC_006570.2 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1671732 rpmG 3191989 rpmG Francisella tularensis subsp. tularensis SCHU S4 50S ribosomal protein L33 YP_170520.1 1671577 D 177416 CDS YP_170521.1 56708625 3192486 1671767..1672453 1 NC_006570.2 Similar to Q87RC3 Septum site-determining protein MinC from Vibrio parahaemolyticus (220 aa). FASTA: opt: 444 Z-score: 518.9 E(): 4.7e-21 Smith-Waterman score: 444; 39.196 identity in 199 aa overlap; septum site-determining protein MinC 1672453 minC 3192486 minC Francisella tularensis subsp. tularensis SCHU S4 septum site-determining protein MinC YP_170521.1 1671767 D 177416 CDS YP_170522.1 56708626 3192434 1672493..1673317 1 NC_006570.2 Similar to Q8FWX1 Septum site-determining protein MinD from Brucella suis(271 aa). FASTA: opt: 1091 Z-score: 1181.8 E(): 5.6e-58 Smith-Waterman score: 1091; 62.825 identity in 269 aa overlap; septum site-determining protein MinD 1673317 minD 3192434 minD Francisella tularensis subsp. tularensis SCHU S4 septum site-determining protein MinD YP_170522.1 1672493 D 177416 CDS YP_170523.1 56708627 3191992 1673320..1673592 1 NC_006570.2 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1673592 minE 3191992 minE Francisella tularensis subsp. tularensis SCHU S4 cell division topological specificity factor MinE YP_170523.1 1673320 D 177416 CDS YP_170524.1 56708628 3191486 1673606..1674409 1 NC_006570.2 Similar to YRBF_HAEIN Probable ABC transporter ATP-binding protein HI1087 from Haemophilus influenzae (264 aa). FASTA: opt: 861 Z-score: 970.8 E(): 3.2e-46 Smith-Waterman score: 861; 50.958identity in 261 aa overlap Equivalent to yrbF of yrb operon in E.coli ORF ftt1608; ABC transporter ATP-binding protein 1674409 3191486 FTT_1608 Francisella tularensis subsp. tularensis SCHU S4 ABC transporter ATP-binding protein YP_170524.1 1673606 D 177416 CDS YP_170525.1 56708629 3191579 1674413..1675177 1 NC_006570.2 Similar Q8VUQ9 Toluene resistance protein Trg1 from Pseudomonas putida (265 aa). FASTA: opt: 793 Z-score: 934.5 E(): 3.4e-44 Smith-Waterman score: 793; 55.869 identity in 213 aa overlap Equivalent to yrbE of yrb operon in E.coli ORF ftt1609; ABC transporter permease 1675177 3191579 FTT_1609 Francisella tularensis subsp. tularensis SCHU S4 ABC transporter permease YP_170525.1 1674413 D 177416 CDS YP_003097806.1 255961466 8303684 1675177..1675710 1 NC_006570.2 Similar to YRBD_HAEIN P45029 Hypothetical protein HI1085 from Haemophilus influenzae (167 aa).; hypothetical protein 1675710 8303684 FTT_1610 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_003097806.1 1675177 D 177416 CDS YP_170526.1 56708630 3191122 1675778..1676446 1 NC_006570.2 Similar to YRBC_ECOLI Protein yrbC precursor from E. coli (211 aa). FASTA: opt: 230 Z-score: 278.3 E(): 1.2e-07 Smith-Waterman score: 230; 26.147 identity in 218 aa overlap Equivalent to yrbC of yrb operon in E.coli ORF ftt1611; hypothetical protein 1676446 3191122 FTT_1611 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170526.1 1675778 D 177416 CDS YP_170527.1 56708631 3191129 1676446..1676739 1 NC_006570.2 Similar to YRBB_ECOLI Hypothetical protein yrbB from E. coli (97 aa). FASTA: opt: 116 Z-score: 165.8 E(): 0.22 Smith-Waterman score: 116; 31.915identity in 47 aa overlap Equivalent to yrbB of yrb operon in E.coli ORF ftt1612; hypothetical protein 1676739 3191129 FTT_1612 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170527.1 1676446 D 177416 CDS YP_170528.1 56708632 3191104 1676756..1676992 1 NC_006570.2 Similar to Q8ZB55 BolA-like protein from Yersinia pestis (87 aa). FASTA: opt: 163 Z-score: 236.9 E(): 2.4e-05 Smith-Waterman score: 163; 35.526 identity in 76 aa overlap Equivalent to yrbA of yrb operon in E.coli ORF ftt1613; BolA-like protein 1676992 3191104 FTT_1613 Francisella tularensis subsp. tularensis SCHU S4 BolA-like protein YP_170528.1 1676756 D 177416 CDS YP_170530.1 56708634 3192194 join(1678189..1678515,1678515..1678973) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1678973 isftu1 3192194 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170530.1 1678189 D 177416 CDS YP_170531.1 56708635 3192385 1679445..1680839 1 NC_006570.2 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1680839 cysS 3192385 cysS Francisella tularensis subsp. tularensis SCHU S4 cysteinyl-tRNA synthetase YP_170531.1 1679445 D 177416 CDS YP_170532.1 56708636 3192421 1680843..1681787 1 NC_006570.2 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1681787 hemK 3192421 hemK Francisella tularensis subsp. tularensis SCHU S4 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_170532.1 1680843 D 177416 CDS YP_170533.2 255961467 3192293 join(1683438..1683764,1683764..1684222) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1684222 isftu1 3192293 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170533.2 1683438 D 177416 CDS YP_170535.1 56708639 3192187 complement(1685495..1686415) 1 NC_006570.2 ORF ftt1622c; hypothetical protein 1686415 3192187 FTT_1622c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170535.1 1685495 R 177416 CDS YP_170538.1 56708642 3192193 complement(1687246..1687836) 1 NC_006570.2 ORF ftt1625c; hypothetical protein 1687836 3192193 FTT_1625c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170538.1 1687246 R 177416 CDS YP_170539.1 56708643 3192192 complement(1687847..1689253) 1 NC_006570.2 ORF ftt1626c; hypothetical protein 1689253 3192192 FTT_1626c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170539.1 1687847 R 177416 CDS YP_170540.1 56708644 3191084 complement(1689250..1690053) 1 NC_006570.2 ORF ftt1627c; hypothetical protein 1690053 3191084 FTT_1627c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170540.1 1689250 R 177416 CDS YP_170541.1 56708645 3191086 complement(1690454..1691764) 1 NC_006570.2 Similar to Q88C61 metal ion transporter from Pseudomonas putida (446 aa). FASTA: opt: 1033 Z-score: 1180.6 E(): 6.5e-58 Smith-Waterman score: 1035; 40.455 identity in 440 aa overlap ORF ftt1628c; metal ion transporter 1691764 3191086 FTT_1628c Francisella tularensis subsp. tularensis SCHU S4 metal ion transporter YP_170541.1 1690454 R 177416 CDS YP_170542.1 56708646 3192479 complement(1691775..1693454) 1 NC_006570.2 ORF ftt1629c; hypothetical protein 1693454 3192479 FTT_1629c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170542.1 1691775 R 177416 CDS YP_170543.1 56708647 3191659 complement(1693525..1694991) 1 NC_006570.2 Similar to PUTP_ECOLI Sodium/proline symporter from E. coli (501 aa). FASTA: opt: 1536 Z-score: 1735.2 E(): 8.4e-89 Smith-Waterman score: 1536; 46.531identity in 490 aa overlap; sodium/proline permease 1694991 putP 3191659 putP Francisella tularensis subsp. tularensis SCHU S4 sodium/proline permease YP_170543.1 1693525 R 177416 CDS YP_170544.1 56708648 3192549 complement(1695297..1696283) 1 NC_006570.2 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 1696283 glpX 3192549 glpX Francisella tularensis subsp. tularensis SCHU S4 fructose 1,6-bisphosphatase II YP_170544.1 1695297 R 177416 CDS YP_170545.1 56708649 3191085 complement(1696303..1696941) 1 NC_006570.2 Similar to AAO91263 (Q83AV9) Hypothetical protein from Coxiella burnetti (205 aa). FASTA: opt: 552 Z-score: 685.2 E(): 2.6e-30 Smith-Waterman score: 552; 41.000 identity in 200 aa overlap ORF ftt1632c; hypothetical protein 1696941 3191085 FTT_1632c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170545.1 1696303 R 177416 CDS YP_170546.1 56708650 3191087 complement(1696950..1698404) 1 NC_006570.2 Similiar to AAP09999 (Q81BU4) Lysine-specific permease from Bacillus cereus (491 aa). FASTA: opt: 1734 Z-score: 1972.4 bits: 374.4 E(): 5.2e-102 Smith-Waterman score: 1817; 53.459 identity in 477 aa overlap ORF ftt1633c; amino acid transporter 1698404 3191087 FTT_1633c Francisella tularensis subsp. tularensis SCHU S4 amino acid transporter YP_170546.1 1696950 R 177416 CDS YP_170547.1 56708651 3192381 complement(1698652..1699320) 1 NC_006570.2 ORF ftt1634c; hypothetical protein 1699320 3192381 FTT_1634c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170547.1 1698652 R 177416 CDS YP_170548.1 56708652 3191691 1699442..1701943 1 NC_006570.2 Similar to Q9I0M3 Cell division protein FtsK from Rickettsia prowazekii (811 aa). FASTA: opt: 2030 Z-score: 2059.0 E(): 7.7e-107 Smith-Waterman score: 2197; 45.808 identity in 823 aa overlap; cell division protein 1701943 ftsK 3191691 ftsK Francisella tularensis subsp. tularensis SCHU S4 cell division protein YP_170548.1 1699442 D 177416 CDS YP_170549.1 56708653 3190782 1701944..1702561 1 NC_006570.2 Similar to LOLA_PSEAE (Q9I0M4) Outer-membrane lipoproteins carrier from Pseudomonas aeruginosa (208 aa). FASTA: opt: 384 Z-score: 440.9 E(): 1e-16 Smith-Waterman score: 384; 30.476 identity in 210 aa overlap; lipoprotein releasing system outer membrane lipoproteins carrier 1702561 lolA 3190782 lolA Francisella tularensis subsp. tularensis SCHU S4 lipoprotein releasing system outer membrane lipoproteins carrier YP_170549.1 1701944 D 177416 CDS YP_170550.1 56708654 3192340 complement(1702959..1703162) 1 NC_006570.2 ORF ftt1637c; hypothetical protein 1703162 3192340 FTT_1637c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170550.1 1702959 R 177416 CDS YP_170551.1 56708655 3191471 1703274..1704728 1 NC_006570.2 Similar to Q9KNI3 Potassium uptake protein TrkH from Vibrio cholerae (485 aa). FASTA: opt: 1470 Z-score: 1682.5 E(): 7.3e-86 Smith-Waterman score: 1470; 43.827 identity in 486 aa overlap; potassium uptake protein 1704728 trkH 3191471 trkH Francisella tularensis subsp. tularensis SCHU S4 potassium uptake protein YP_170551.1 1703274 D 177416 CDS YP_170552.1 56708656 3190827 complement(1704743..1705288) 1 NC_006570.2 ORF ftt1639c; hypothetical protein 1705288 3190827 FTT_1639c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170552.1 1704743 R 177416 CDS YP_008492918.1 537470121 8303709 complement(1705311..1706012) 1 NC_006570.2 hypothetical protein 1706012 8303709 FTT_1640c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_008492918.1 1705311 R 177416 CDS YP_170553.1 56708657 3192336 1708832..1710256 1 NC_006570.2 Similar to O86076 Sucrose hydrolase from E. coli (477 aa). FASTA: opt: 787 Z-score: 912.8 E(): 5.4e-43 Smith-Waterman score: 787; 31.929 identity in 451 aa overlap ORF ftt1644; beta-fructofuranosidase 1710256 3192336 FTT_1644 Francisella tularensis subsp. tularensis SCHU S4 beta-fructofuranosidase YP_170553.1 1708832 D 177416 CDS YP_170554.1 56708658 3191089 1710275..1711507 1 NC_006570.2 Similar to Q8EDM5 Conserved hypothetical protein from Shewanella oneidensis (384 aa). FASTA: opt: 372 Z-score: 419.7 E(): 1.6e-15 Smith-Waterman score: 372; 23.018 identity in 391 aa overlap ORF ftt1645; hypothetical protein 1711507 3191089 FTT_1645 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170554.1 1710275 D 177416 CDS YP_170556.1 56708660 3191654 complement(1712449..1713195) 1 NC_006570.2 Similar to Q9WYG8 Dihydroorotate dehydrogenase from Pyrobaculum aerophilum (297 aa). FASTA: opt: 148 Z-score: 178.6 E(): 0.043 Smith-Waterman score: 191; 26.568 identity in 271 aa overlap; diyroorotate dehydrogenase 1713195 pyrD 3191654 pyrD Francisella tularensis subsp. tularensis SCHU S4 diyroorotate dehydrogenase YP_170556.1 1712449 R 177416 CDS YP_170557.1 56708661 3191652 complement(1713197..1713841) 1 NC_006570.2 Similar to PYRF_STAAM (Q9LCT0) Orotidine 5'-phosphate decarboxylase from Bradyrhizobium japonicum (237 aa). FASTA: opt: 228 z-score: 280.6 E(): 8.8e-08 Smith-Waterman score: 243; 28.061identity in 196 aa overlap; orotidine 5'-phosphate decarboxylase 1713841 pyrF 3191652 pyrF Francisella tularensis subsp. tularensis SCHU S4 orotidine 5'-phosphate decarboxylase YP_170557.1 1713197 R 177416 CDS YP_170558.1 56708662 3190851 complement(1717533..1718081) 1 NC_006570.2 Similar to Q93LJ4 Periplasmic monofunctional chorismate mutase from Salmonella typhimurium (181 aa). FASTA: opt: 186 Z-score: 223.0 E(): 0.00014 Smith-Waterman score: 186; 31.746 identity in 126 aa overlap ORF ftt1650; chorismate mutase 1718081 3190851 FTT_1650c Francisella tularensis subsp. tularensis SCHU S4 chorismate mutase YP_170558.1 1717533 R 177416 CDS YP_170559.1 56708663 3192480 1718233..1718859 1 NC_006570.2 Similar to Q8KDD5 Hypothetical protein from Chlorobium tepidum (215 aa). FASTA: opt: 569 z-score: 706.8 E(): 1.6e-31 Smith-Waterman score: 569; 40.580 identity in 207 aa overlap ORF ftt1651; hypothetical protein 1718859 3192480 FTT_1651 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170559.1 1718233 D 177416 CDS YP_170560.1 56708664 3190850 complement(1718860..1719729) 1 NC_006570.2 Similar to Q8EFC8 Transcriptional regulator, LysR family from Shewanella oneidensis (291 aa). FASTA: opt: 443 Z-score: 527.9 E(): 1.5e-21 Smith-Waterman score: 443; 29.831 identity in 295 aa overlap ORF ftt1652c; LysR family transcriptional regulator 1719729 3190850 FTT_1652c Francisella tularensis subsp. tularensis SCHU S4 LysR family transcriptional regulator YP_170560.1 1718860 R 177416 CDS YP_170561.1 56708665 3190846 1719855..1720262 1 NC_006570.2 ORF ftt1653; hypothetical protein 1720262 3190846 FTT_1653 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170561.1 1719855 D 177416 CDS YP_170562.1 56708666 3191565 1720351..1721316 1 NC_006570.2 Similar to AAO90332 (Q83DE0) Multidrug resistance protein from Coxiella burnetii (331 aa). FASTA: opt: 406 z-score: 447.9 E(): 4.2e-17 Smith-Waterman score: 406; 28.135 identity in 327 aa overlap; HlyD family secretion protein 1721316 emrA2 3191565 emrA2 Francisella tularensis subsp. tularensis SCHU S4 HlyD family secretion protein YP_170562.1 1720351 D 177416 CDS YP_170563.1 56708667 3190881 1721291..1722355 1 NC_006570.2 ORF ftt1655; hypothetical protein 1722355 3190881 FTT_1655 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170563.1 1721291 D 177416 CDS YP_170564.1 56708668 3190837 complement(1722471..1723022) 1 NC_006570.2 Similiar to Q8PGE2 Hypothetical protein from Xanthomonas axonopodis(186 aa). FASTA: opt: 578 Z-score: 703.0 E(): 2.6e-31 Smith-Waterman score: 578; 51.462 identity in 171 aa overlap ORF ftt1656c; hypothetical protein 1723022 3190837 FTT_1656c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170564.1 1722471 R 177416 CDS YP_170566.1 56708670 3190815 complement(1723736..1723990) 1 NC_006570.2 Similar to BAC68773 (Q82P70) Hypothetical protein from Streptomyces avermitilis (95 aa). FASTA: opt: 135 Z-score: 188.6 E(): 0.012 Smith-Waterman score: 135; 25.316 identity in 79 aa overlap ORF ftt1658c; hypothetical protein 1723990 3190815 FTT_1658c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170566.1 1723736 R 177416 CDS YP_170567.1 56708671 3190833 1724243..1725268 1 NC_006570.2 ORF ftt1659; hypothetical protein 1725268 3190833 FTT_1659 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170567.1 1724243 D 177416 CDS YP_170568.1 56708672 3191655 complement(1725296..1726642) 1 NC_006570.2 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; dihydroorotase 1726642 pyrC 3191655 pyrC Francisella tularensis subsp. tularensis SCHU S4 dihydroorotase YP_170568.1 1725296 R 177416 CDS YP_170569.1 56708673 3190790 1726774..1727454 1 NC_006570.2 catalyzes the S-adenosylmethionine-dependent transmethylation of thiopurine compounds; may be involved in selenium cycling by forming dimethylselenide and/or dimethyldiselenide; thiopurine S-methyltransferase 1727454 tmpT 3190790 tmpT Francisella tularensis subsp. tularensis SCHU S4 thiopurine S-methyltransferase YP_170569.1 1726774 D 177416 CDS YP_170570.1 56708674 3191074 1729048..1730214 1 NC_006570.2 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1730214 carA 3191074 carA Francisella tularensis subsp. tularensis SCHU S4 carbamoyl phosphate synthase small subunit YP_170570.1 1729048 D 177416 CDS YP_170571.1 56708675 3191275 1730219..1733503 1 NC_006570.2 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1733503 carB 3191275 carB Francisella tularensis subsp. tularensis SCHU S4 carbamoyl phosphate synthase large subunit YP_170571.1 1730219 D 177416 CDS YP_170572.1 56708676 3191656 1733645..1734565 1 NC_006570.2 Similar to PYRB_METJA Aspartate carbamoyltransferase from Methanococcus jannaschii (306 aa). FASTA: opt: 943 Z-score: 1081.5 E(): 2.2e-52 Smith-Waterman score: 943; 49.338 identity in 302 aa overlap; aspartate carbamoyltransferase 1734565 pyrB 3191656 pyrB Francisella tularensis subsp. tularensis SCHU S4 aspartate carbamoyltransferase YP_170572.1 1733645 D 177416 CDS YP_170573.1 56708677 3192365 complement(1734578..1735465) 1 NC_006570.2 Similar to AAP10961 (Q819E3) 3-hydroxyisobutyrate dehydrogenase from Bacillus cereus (292 aa). FASTA: opt: 384 z-score: 452.2 E(): 2.4e-17 Smith-Waterman score: 384; 24.483 identity in 290 aa overlap ORF ftt1666c; 3-hydroxyisobutyrate dehydrogenase 1735465 3192365 FTT_1666c Francisella tularensis subsp. tularensis SCHU S4 3-hydroxyisobutyrate dehydrogenase YP_170573.1 1734578 R 177416 CDS YP_170574.1 56708678 3191894 1735953..1736189 1 NC_006570.2 ORF ftt1667; hypothetical protein 1736189 3191894 FTT_1667 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170574.1 1735953 D 177416 CDS YP_170575.1 56708679 3191410 1736516..1737739 1 NC_006570.2 Similar to Q8ZGH6 Serine transporter from Yersinia pestis (433 aa). FASTA: opt: 1336 Z-score: 1510.1 E(): 2.9e-76 Smith-Waterman score: 1336; 46.078identity in 408 aa overlap.; serine transporter 1737739 sdaC2 3191410 sdaC2 Francisella tularensis subsp. tularensis SCHU S4 serine transporter YP_170575.1 1736516 D 177416 CDS YP_170576.1 56708680 3190921 join(1738723..1739049,1739049..1739507) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1739507 isftu1 3190921 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170576.1 1738723 D 177416 CDS YP_170577.1 56708681 3191624 1740586..1741653 1 NC_006570.2 Similar to RIBD_AQUAE Riboflavin biosynthesis protein ribD from Aquiflex aeolicus (356 aa). FASTA: opt: 915 z-score: 1060.1 E(): 3.4e-51 Smith-Waterman score: 916; 43.824 identity in 340 aa overlap; riboflavin biosynthesis protein ribD 1741653 ribD 3191624 ribD Francisella tularensis subsp. tularensis SCHU S4 riboflavin biosynthesis protein ribD YP_170577.1 1740586 D 177416 CDS YP_170578.1 56708682 3191625 1741646..1742251 1 NC_006570.2 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1742251 ribB 3191625 ribB Francisella tularensis subsp. tularensis SCHU S4 riboflavin synthase subunit alpha YP_170578.1 1741646 D 177416 CDS YP_170579.1 56708683 3191626 1742244..1743455 1 NC_006570.2 Similar to GCH2_AQUAE Riboflavin biosynthesis protein ribA from Aquiflex aeolicus (406 aa). FASTA: opt: 1135 z-score: 1316.5 E(): 1.8e-65 Smith-Waterman score: 1135; 46.305 identity in 406 aa overlap; riboflavin biosynthesis protein ribA/GTP-cyclohydrolase II 1743455 ribA 3191626 ribA Francisella tularensis subsp. tularensis SCHU S4 riboflavin biosynthesis protein ribA/GTP-cyclohydrolase II YP_170579.1 1742244 D 177416 CDS YP_170580.1 56708684 3191622 1743465..1743908 1 NC_006570.2 Similar to AAO90192 (Q83DP8) Riboflavin synthase, beta subunit from Coxiella burnetii (151 aa). FASTA: opt: 496 z-score: 645.4 E(): 4.2e-28 Smith-Waterman score: 496; 53.571 identity in 140 aa overlap; riboflavin synthase subunit beta 1743908 ribH 3191622 ribH Francisella tularensis subsp. tularensis SCHU S4 riboflavin synthase subunit beta YP_170580.1 1743465 D 177416 CDS YP_170581.1 56708685 3191511 1743905..1744429 1 NC_006570.2 Similar to DEF_NEIMA (Q9JQN0) Peptide deformylase from Neisseria meningitidis (167 aa). FASTA: opt: 465 z-score: 571.7 E(): 5.4e-24 Smith-Waterman score: 465; 46.914 identity in 162 aa overlap; peptide deformylase 1744429 def2 3191511 def2 Francisella tularensis subsp. tularensis SCHU S4 peptide deformylase YP_170581.1 1743905 D 177416 CDS YP_170582.1 56708686 3192368 1744511..1745503 1 NC_006570.2 ORF ftt1676; hypothetical protein 1745503 3192368 FTT_1676 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170582.1 1744511 D 177416 CDS YP_170583.1 56708687 3191949 complement(1745523..1746668) 1 NC_006570.2 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1746668 mnmA 3191949 mnmA Francisella tularensis subsp. tularensis SCHU S4 tRNA-specific 2-thiouridylase MnmA YP_170583.1 1745523 R 177416 CDS YP_170584.1 56708688 3192146 complement(1746616..1748400) 1 NC_006570.2 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 1748400 lepA 3192146 lepA Francisella tularensis subsp. tularensis SCHU S4 GTP-binding protein LepA YP_170584.1 1746616 R 177416 CDS YP_170585.1 56708689 3192339 1748670..1748942 1 NC_006570.2 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 1748942 rpsT 3192339 rpsT Francisella tularensis subsp. tularensis SCHU S4 30S ribosomal protein S20 YP_170585.1 1748670 D 177416 CDS YP_170586.1 56708690 3191055 complement(1749016..1749372) 1 NC_006570.2 Similar to Q8KTI1 Outer membrane lipoprotein OmlA from Azaobacter vinelandii (171 aa). FASTA: opt: 208 Z-score: 273.7 E(): 2.1e-07 Smith-Waterman score: 208; 30.392 identity in 102 aa overlap; outer membrane lipoprotein 1749372 olmA 3191055 olmA Francisella tularensis subsp. tularensis SCHU S4 outer membrane lipoprotein YP_170586.1 1749016 R 177416 CDS YP_170587.1 56708691 3191473 complement(1749380..1749976) 1 NC_006570.2 Similar to Q8EK08 Phosphoheptose isomerase from Shewanella oneidensis (197 aa). FASTA: opt: 705 z-score: 847.8 E(): 2.3e-39 Smith-Waterman score: 705; 53.684 identity in 190 aa overlap; phosphoheptose isomerase 1749976 lpcA 3191473 lpcA Francisella tularensis subsp. tularensis SCHU S4 phosphoheptose isomerase YP_170587.1 1749380 R 177416 CDS YP_170588.1 56708692 3192371 complement(1752525..1753676) 1 NC_006570.2 Similar to Q8NM37 Permeases of the major facilitator superfamily from Corynebacterium glutamicum (398 aa). FASTA: opt: 440 z-score: 489.8 E(): 2e-19 Smith-Waterman score: 440; 24.211 identity in 380 aa overlap ORF ftt1683c; major facilitator transporter 1753676 3192371 FTT_1683c Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_170588.1 1752525 R 177416 CDS YP_170589.1 56708693 3192501 1753773..1754675 1 NC_006570.2 Similar to Q8D3N4 Transcriptional regulator from Vibrio vulnificus (307 aa). FASTA: opt: 510 Z-score: 590.3 E(): 5e-25 32.975 identity in 279 aa overlap ORF ftt1684; transcriptional regulator 1754675 3192501 FTT_1684 Francisella tularensis subsp. tularensis SCHU S4 transcriptional regulator YP_170589.1 1753773 D 177416 CDS YP_170591.1 56708695 3192358 complement(1755756..1756424) 1 NC_006570.2 Similar to Q894C5 Proline synthetase associated protein from Clostridium tetani (225 aa). FASTA: opt: 462 z-score: 549.8 E(): 8.9e-23 37.220 identity in 223 aa overlap ORF ftt1686c; hypothetical protein 1756424 3192358 FTT_1686c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170591.1 1755756 R 177416 CDS YP_170592.1 56708696 3192244 complement(1756421..1757038) 1 NC_006570.2 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1757038 gidB 3192244 gidB Francisella tularensis subsp. tularensis SCHU S4 16S rRNA methyltransferase GidB YP_170592.1 1756421 R 177416 CDS YP_170593.1 56708697 3192349 1757138..1758343 1 NC_006570.2 Similar to Q8EFB8 Tyrosine-specific transport protein from Shewanella oneidensis (395 aa). FASTA: opt: 854 z-score: 967.0 E(): 5.2e-46 38.378 identity in 370 aa overlap ORF ftt1688; aromatic amino acid HAAP transporter 1758343 3192349 FTT_1688 Francisella tularensis subsp. tularensis SCHU S4 aromatic amino acid HAAP transporter YP_170593.1 1757138 D 177416 CDS YP_170594.1 56708698 3192347 complement(1758340..1759032) 1 NC_006570.2 Similar to CAD84514 (Q82WQ9) Possible transmembrane protein from Nitrosomonas europaea (223 aa). FASTA: opt: 294 z-score: 358.6 E(): 4e-12 25.481 identity in 208 aa overlap ORF ftt1689c; hypothetical protein 1759032 3192347 FTT_1689c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170594.1 1758340 R 177416 CDS YP_170595.1 56708699 3192341 1759436..1760101 1 NC_006570.2 Similar to Q9ABA7 NADH dehydrogenase from Caulobacter crescentus (220 aa). FASTA: opt: 429 z-score: 535.0 E(): 6e-22 35.545 identity in 211 aa overlap ORF ftt1690; NADH dehydrogenase 1760101 3192341 FTT_1690 Francisella tularensis subsp. tularensis SCHU S4 NADH dehydrogenase YP_170595.1 1759436 D 177416 CDS YP_170596.1 56708700 3192348 1760372..1760896 1 NC_006570.2 This CDS is disrupted by the insertion of an ISFtu1 element occurring very near the C-terminal end. It is not clear whether this insertion affects the function of the protein. ORF ftt1691; hypothetical protein 1760896 3192348 FTT_1691 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170596.1 1760372 D 177416 CDS YP_170621.1 56708725 3191802 join(1760920..1761246,1761246..1761704) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1761704 isftu1 3191802 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170621.1 1760920 D 177416 CDS YP_170598.1 56708702 3191497 complement(1761847..1762611) 1 NC_006570.2 Similar to Q87SC0 conserved hypothetical protein from Vibrio parahaemolyticus (258 aa). FASTA: opt: 724 z-score: 845.1 E(): 3.2e-39 46.094 identity in 256 aa overlap ORF ftt1693c; hypothetical protein 1762611 3191497 FTT_1693c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170598.1 1761847 R 177416 CDS YP_170599.1 56708703 3192354 complement(1763252..1763686) 1 NC_006570.2 Similar to Q8ZCK6 membrane protein (Hypothetical) from Yersinia pestis (175 aa). FASTA: opt:353 z-score 450 E():2.9e-17 35.9identity in 142 aa overlap ORF ftt1694c; hypothetical protein 1763686 3192354 FTT_1694c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170599.1 1763252 R 177416 CDS YP_170600.1 56708704 3191890 1763937..1764224 1 NC_006570.2 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1764224 groES 3191890 groES Francisella tularensis subsp. tularensis SCHU S4 co-chaperonin GroES YP_170600.1 1763937 D 177416 CDS YP_170601.1 56708705 3191101 1764262..1765896 1 NC_006570.2 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 1765896 groEL 3191101 groEL Francisella tularensis subsp. tularensis SCHU S4 molecular chaperone GroEL YP_170601.1 1764262 D 177416 CDS YP_170602.2 255961468 3190864 complement(join(1766112..1766570,1766570..1766896)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1766896 isftu1 3190864 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170602.2 1766112 R 177416 CDS YP_170603.1 56708707 3191879 complement(1766954..1767670) 1 NC_006570.2 Similar to FDH_PSESR Formate dehydrogenase from Pseudomonas sp. (strain 101) (400 aa). FASTA: opt: 1074 z-score: 1253.7, E(): 5.5e-62, 66.949 identity in 236 aa overlap. This CDS is disrupted by the insertion of an ISFtu1 element occurring very near the C-terminal end. It is not clear whether this insertion affects the function of the protein.; formate dehydrogenase 1767670 fdh 3191879 fdh Francisella tularensis subsp. tularensis SCHU S4 formate dehydrogenase YP_170603.1 1766954 R 177416 CDS YP_170604.1 56708708 3191298 1773260..1775722 1 NC_006570.2 Similar to AAP58968.1 (Q7X3I9) PdpA from Francisella novicida (820 aa). BLAST Score = 1545 bits (4000), Expect = 0.0 Identities = 777/820 (94), Positives = 787/820 (95). Identical to FTT1344. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281; hypothetical protein 1775722 pdpA2 3191298 pdpA2 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170604.1 1773260 D 177416 CDS YP_170605.1 56708709 3191305 1775727..1779008 1 NC_006570.2 Similar to AAP58967.1 (Q7X3J0) PdpB from Francisella novicida (1093 aa). BLAST Score = 1914 bits (4959), Expect = 0.0 Identities = 975/1093 (89),Positives = 988/1093 (90). This protein is identical to FTT1345. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..140828; hypothetical protein 1779008 pdpB2 3191305 pdpB2 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170605.1 1775727 D 177416 CDS YP_170606.1 56708710 3192364 1778998..1779375 1 NC_006570.2 Identical to FTT1346. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281 ORF ftt1701; hypothetical protein 1779375 3192364 FTT_1701 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170606.1 1778998 D 177416 CDS YP_170607.1 56708711 3192355 1779388..1779882 1 NC_006570.2 Similar to AAP58969.1 (Q7XI38) unknown protein from Francisella novicida (164 aa). BLAST Score = 305 bits (780), Expect = 2e-82 Identities = 163/164 (99),Positives = 163/164 (99). Identical to FTT1347. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281 ORF ftt1702; hypothetical protein 1779882 3192355 FTT_1702 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170607.1 1779388 D 177416 CDS YP_170608.1 56708712 3192367 1779887..1781617 1 NC_006570.2 1-213 aa similar to AAP58970.1 (Q7X3I7) unknown Francisella novicida (212 aa). BLAST Score 352 ,Expect = 1e-95 Identities = 177/209 (84), Positives = 189/209 (90). 330-580 aa similar to AAP58971.1 (Q7X3I6) unknown protein from Francisella tularensis subsp. novicida (251 aa). BLAST Score = 483 bits (1244), Expect = e-135 Identities = 243/251 (96), Positives = 249/251 (99). Identical to FTT1348. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281. Protein fusion product of two hypothetical proteins in F. novicida. ORF ftt1703; hypothetical protein 1781617 3192367 FTT_1703 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170608.1 1779887 D 177416 CDS YP_170609.1 56708713 3192362 1781618..1782139 1 NC_006570.2 Similar to AAP58972.1 (Q7X3I5) unknown protein from Francisella novicida (173 aa). BLAST Score = 336, Expect = 1e-91 Identities = 170/173 (98), Positives = 171/173 (98). Identical to FTT1349. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281 ORF ftt1704; hypothetical protein 1782139 3192362 FTT_1704 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170609.1 1781618 D 177416 CDS YP_170610.1 56708714 3192369 1782152..1783582 1 NC_006570.2 Similar to AAP58973.1 (Q7X3I4) unknown protein from Francisella novicida (476 aa). BLAST Score = 864 bits (2233), Expect = 0.0 Identities = 433/476 (90),Positives = 437/476 (91). Identical to FTT1350. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281 ORF ftt1705; hypothetical protein 1783582 3192369 FTT_1705 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170610.1 1782152 D 177416 CDS YP_170611.1 56708715 3192554 1783595..1784218 1 NC_006570.2 Similar to AAP58974.1 (Q7X3I3) unknown protein from Francisella novicida (207 aa). BLAST Score = 391 bits (1005), Expect = e-108 Identities = 194/207 (93),Positives = 195/207 (94). Identical to FTT1351. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281 ORF ftt1706; hypothetical protein 1784218 3192554 FTT_1706 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170611.1 1783595 D 177416 CDS YP_170612.1 56708716 3192534 1784240..1785391 1 NC_006570.2 Similar to AAP58975.1 (Q7X3I2) unknown protein from Francisella novicida (262 aa), BLAST Score = 443 bits (1140), Expect = e-12 Identities = 229/262 (87),Positives = 235/262 (89). Identical to FTT1352. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281 ORF ftt1707; hypothetical protein 1785391 3192534 FTT_1707 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170612.1 1784240 D 177416 CDS YP_170613.1 56708717 3192550 1785357..1786130 1 NC_006570.2 Similar to AAP58976.1 (Q7X3I1) unknown protein from Francisella novicida (257 aa). BLAST Score = 412, Expect = e-114 Identities = 213/257 (82), Positives = 213/257 (82). Identical to FTT1353. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281 ORF ftt1708; hypothetical protein 1786130 3192550 FTT_1708 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170613.1 1785357 D 177416 CDS YP_170614.1 56708718 3192535 1786170..1790156 1 NC_006570.2 Similar to AAP58966.1 PdpC from Francisella novicida (1218 aa). BLAST Score = 2172, Expect = 0.0 Identities = 1089/1220 (89), Positives = 1120/1220 (91),Gaps = 3/1220 (0). Identical to FTT1354. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281; hypothetical protein 1790156 pdpC2 3192535 pdpC2 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170614.1 1786170 D 177416 CDS YP_170615.1 56708719 3190953 1790174..1790749 1 NC_006570.2 Similar to AAP58977.1 (Q7X3I0) unknown protein from Francisella novicida (188 aa). BLAST Score = 321, Expect = 3e-87 Identities = 156/174 (89), Positives = 162/174 (93). Identical to FTT1355. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281 ORF ftt1710; hypothetical protein 1790749 3190953 FTT_1710 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170615.1 1790174 D 177416 CDS YP_170616.1 56708720 3192363 complement(1790756..1791961) 1 NC_006570.2 Similar to AAP58965.1 (Q7C3J6) IglD from Francisella novicida (398 aa). BLAST Score = 746, Expect = 0.0 Identities = 382/398 (95), Positives = 383/398 (96) Identical to FTT1356. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281; intracellular growth locus subunit D 1791961 iglD2 3192363 iglD2 Francisella tularensis subsp. tularensis SCHU S4 intracellular growth locus subunit D YP_170616.1 1790756 R 177416 CDS YP_170617.1 56708721 3191814 complement(1791973..1792608) 1 NC_006570.2 Similar to AAP58964.1 (Q7X3J5) IglC from Francisella novicida (23 kDa protein) (211 aa). BLAST Score = 405,Expect = e-112 Identities = 209/211 (99), Positives = 210/211 (99). Identical to FTT1357. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281; intracellular growth locus subunit C 1792608 iglC2 3191814 iglC2 Francisella tularensis subsp. tularensis SCHU S4 intracellular growth locus subunit C YP_170617.1 1791973 R 177416 CDS YP_170618.1 56708722 3191488 complement(1792619..1794163) 1 NC_006570.2 Similar to AAP58963.1 (Q7X3J4) IglB from Francisella novicida (514 aa). BLAST Score = 997, Expect = 0.0 Identities = 496/514 (96), Positives = 499/514 (97). Identical to FTT1358. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281; intracellular growth locus subunit B 1794163 iglB2 3191488 iglB2 Francisella tularensis subsp. tularensis SCHU S4 intracellular growth locus subunit B YP_170618.1 1792619 R 177416 CDS YP_170619.1 56708723 3191759 complement(1794153..1794743) 1 NC_006570.2 Similar to AAP58962.1 (Q7X3J5) IglA from Francisella novicida (184 aa). BLAST Score = 350, Expect = 6e-96 Identities = 181/184 (98), Positives = 181/184 (98). Identical to FTT1359. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281; intracellular growth locus subunit A 1794743 iglA2 3191759 iglA2 Francisella tularensis subsp. tularensis SCHU S4 intracellular growth locus subunit A YP_170619.1 1794153 R 177416 CDS YP_170620.1 56708724 3191313 complement(1794788..1798375) 1 NC_006570.2 Similar to AAP58961.1 (Q7C3J6) PdpD from Francisella novicida (1245 aa). BLAST Score = 2194, Expect = 0.0 Identities = 1133/1245 (91), Positives = 1154/1245 (92), Gaps = 50/1245 (4). Identical to FTT1360. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281; hypothetical protein 1798375 pdpD2 3191313 pdpD2 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170620.1 1794788 R 177416 CDS YP_170638.1 56708742 3190844 complement(join(1800731..1801189,1801189..1801515)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1801515 isftu1 3190844 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170638.1 1800731 R 177416 CDS YP_170622.1 56708726 3191665 complement(1802073..1805945) 1 NC_006570.2 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 1805945 purL 3191665 purL Francisella tularensis subsp. tularensis SCHU S4 phosphoribosylformylglycinamidine synthase YP_170622.1 1802073 R 177416 CDS YP_170623.1 56708727 3191669 complement(1805945..1807435) 1 NC_006570.2 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 1807435 purF 3191669 purF Francisella tularensis subsp. tularensis SCHU S4 amidophosphoribosyltransferase YP_170623.1 1805945 R 177416 CDS YP_170624.1 56708728 3191876 complement(1807529..1808875) 1 NC_006570.2 Similar to Q8FHG5 Glutamate decarboxylase beta from E. coli (489 aa). FASTA: opt: 1709 Z-score: 1968.5 bits: 373.6 E(): 8.6e-102 Smith-Waterman score: 1709; 57.011 identity in 435 aa overlap; glutamate decarboxylase 1808875 gad 3191876 gad Francisella tularensis subsp. tularensis SCHU S4 glutamate decarboxylase YP_170624.1 1807529 R 177416 CDS YP_170625.1 56708729 3192138 complement(1808886..1809530) 1 NC_006570.2 Similar to GSP_BACBR (P40683) 4'-phosphopantetheinyl transferase from Bacillus brevis (237 aa). FASTA: opt: 224 Z-score: 292.3 E(): 2.2e-08 Smith-Waterman score: 224; 33.929 identity in 112 aa overlap ORF ftt1723c; hypothetical protein 1809530 3192138 FTT_1723c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170625.1 1808886 R 177416 CDS YP_170626.1 56708730 3191456 complement(1809536..1811065) 1 NC_006570.2 Similar to TOLC_ECOLI (P02930) Outer membrane protein tolC precursor from E. coli (495 aa). FASTA: opt: 548 Z-score: 649.7 E(): 2.7e-28 Smith-Waterman score: 548; 28.000 identity in 425 aa overlap; outer membrane protein TolC 1811065 tolC 3191456 tolC Francisella tularensis subsp. tularensis SCHU S4 outer membrane protein TolC YP_170626.1 1809536 R 177416 CDS YP_170627.1 56708731 3191449 complement(1811074..1811694) 1 NC_006570.2 Similar to Q9JXU0 Protein-L-isoaspartate O-methyltransferase from Neisseria meningitidis (218 aa). FASTA: opt: 335 Z-score: 438.9 E(): 1.5e-16 Smith-Waterman score: 335; 33.659 identity in 205 aa overlap; protein-L-isoaspartate O-methyltransferase 1811694 pcm 3191449 pcm Francisella tularensis subsp. tularensis SCHU S4 protein-L-isoaspartate O-methyltransferase YP_170627.1 1811074 R 177416 CDS YP_170628.1 56708732 3192162 1812014..1813345 1 NC_006570.2 Similar to YEGQ_ECOLI (P76403) protease yegQ from E. coli (453 aa). FASTA: opt: 1828 Z-score: 2215.7 E(): 1.6e-115 Smith-Waterman score: 1828; 61.745identity in 447 aa overlap Truncated ortholog (188 aa) previously reported in Schu as O68834 Hypothetical 21.3 kDa protein and AAC12939 unknown; protease yegQ 1813345 yegQ 3192162 yegQ Francisella tularensis subsp. tularensis SCHU S4 protease yegQ YP_170628.1 1812014 D 177416 CDS YP_170629.1 56708733 3192514 complement(1813386..1814576) 1 NC_006570.2 Similar to Q83CE1 Drug resistance transporter, Bcr/CflA family from Coxiella burnetii (398 aa). FASTA: opt: 957 Z-score: 1006.0 E(): 3.8e-48 Smith-Waterman score: 957; 38.542identity in 384 aa overlap ORF ftt1727c; multidrug resistance protein 1814576 3192514 FTT_1727c Francisella tularensis subsp. tularensis SCHU S4 multidrug resistance protein YP_170629.1 1813386 R 177416 CDS YP_170630.1 56708734 3191701 1814742..1816169 1 NC_006570.2 Similar to Q8D4S6 Na+/H+ antiporter NhaD from Vibrio vulnificus (478 aa). FASTA: opt: 1428 Z-score: 1679.2 E(): 1.2e-85 Smith-Waterman score: 1592; 50.617identity in 486 aa overlap; Na+/H+ antiporter 1816169 nhaD 3191701 nhaD Francisella tularensis subsp. tularensis SCHU S4 Na+/H+ antiporter YP_170630.1 1814742 D 177416 CDS YP_170631.1 56708735 3192505 complement(1817820..1819694) 1 NC_006570.2 Similar to Q97MC6 Amino acid transporter from Clostridium acetobutylicum (620 aa). FASTA: opt: 1338 Z-score: 1514.2 E(): 1.9e-76 Smith-Waterman score: 1338; 37.745 identity in 612 aa overlap ORF ftt1730c; amino acid transporter 1819694 3192505 FTT_1730c Francisella tularensis subsp. tularensis SCHU S4 amino acid transporter YP_170631.1 1817820 R 177416 CDS YP_170632.1 56708736 3191931 complement(1819701..1820705) 1 NC_006570.2 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1820705 obgE 3191931 obgE Francisella tularensis subsp. tularensis SCHU S4 GTPase ObgE YP_170632.1 1819701 R 177416 CDS YP_170633.1 56708737 3192136 complement(1820781..1821977) 1 NC_006570.2 Similar to Q8FGM8 Tyrosine-specific transport protein from E. coli (403 aa). FASTA: opt: 724 Z-score: 839.2 E(): 6.8e-39 Smith-Waterman score: 724; 35.638 identity in 376 aa overlap ORF ftt1732; aromatic amino acid HAAP transporter 1821977 3192136 FTT_1732c Francisella tularensis subsp. tularensis SCHU S4 aromatic amino acid HAAP transporter YP_170633.1 1820781 R 177416 CDS YP_170635.1 56708739 3192246 complement(1823996..1826677) 1 NC_006570.2 Similar to Q8U9E1 Two component sensor kinase from Agrobacterium tumefaciens (900 aa). FASTA: opt: 1625 Z-score: 1777.7 E(): 3.6e-91 Smith-Waterman score: 1625; 32.745 identity in 907 aa overlap; two component sensor protein KdpD 1826677 kdpD 3192246 kdpD Francisella tularensis subsp. tularensis SCHU S4 two component sensor protein KdpD YP_170635.1 1823996 R 177416 CDS YP_170636.1 56708740 3192156 complement(1826781..1827335) 1 NC_006570.2 Similar to Q8R8I7 K+-transporting ATPase, c chain from Thermoanaerobacter tengcogenesis (193 aa). FASTA: opt: 404 Z-score: 471.4 E(): 2.1e-18 Smith-Waterman score: 404; 43.333identity in 180 aa overlap; potassium-transporting ATPase subunit C 1827335 kdpC 3192156 kdpC Francisella tularensis subsp. tularensis SCHU S4 potassium-transporting ATPase subunit C YP_170636.1 1826781 R 177416 CDS YP_170637.1 56708741 3192083 complement(1827352..1829391) 1 NC_006570.2 Similar to ATKB_RHIME (Q92XJ0) Potassium-transporting ATPase B chain from Rhizobium meliloti (680 aa). FASTA: opt: 2393 Z-score: 2638.7 E(): 4.4e-139 Smith-Waterman score: 2393; 55.490 identity in 683 aa overlap; potassium-transporting ATPase subunit B 1829391 kdpB 3192083 kdpB Francisella tularensis subsp. tularensis SCHU S4 potassium-transporting ATPase subunit B YP_170637.1 1827352 R 177416 CDS YP_170649.1 56708753 3190922 complement(join(1831850..1832308,1832308..1832634)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1832634 isftu1 3190922 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170649.1 1831850 R 177416 CDS YP_170639.1 56708743 3191884 complement(1833371..1835068) 1 NC_006570.2 Similar to Q8TT45 Indolepyruvate decarboxylase Methanosarcina activorans (550 aa). FASTA: opt: 1265 Z-score: 1467.5 E(): 7.6e-74 Smith-Waterman score: 1265; 36.909 identity in 550 aa overlap; indolepyruvate decarboxylase 1835068 ipdC 3191884 ipdC Francisella tularensis subsp. tularensis SCHU S4 indolepyruvate decarboxylase YP_170639.1 1833371 R 177416 CDS YP_170640.1 56708744 3192539 1835599..1836522 1 NC_006570.2 Similar to Q87YG1 Signal peptide peptidase SppA, 36K type from Pseudomonas syringae (332 a). FASTA: opt: 839 Z-score: 1007.2 E(): 3.3e-48 Smith-Waterman score: 839; 46.622 identity in 296 aa overlap ORF ftt1746; peptidase 1836522 3192539 FTT_1746 Francisella tularensis subsp. tularensis SCHU S4 peptidase YP_170640.1 1835599 D 177416 CDS YP_170641.1 56708745 3191766 1836576..1837151 1 NC_006570.2 Similar to AAO90156 (Q83DT1) Outer membrane protein OmpH, , from Coxiella burnetii (165 aa). FASTA: opt: 175 Z-score: 183.6 E(): 0.022 Smith-Waterman score: 216; 26.816 identity in 179 aa overlap ORF ftt1747; hypothetical protein 1837151 3191766 FTT_1747 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170641.1 1836576 D 177416 CDS YP_170642.1 56708746 3190942 1837287..1837709 1 NC_006570.2 Similar to AAO91018 (Q83BI7) Rhodanese domain protein Coxiella burnetii (144 aa). FASTA: opt: 279 Z-score: 342.5 E(): 3.5e-11 Smith-Waterman score: 279; 33.094 identity in 139 aa overlap; thiosulfate sulfurtransferase 1837709 glpe 3190942 glpe Francisella tularensis subsp. tularensis SCHU S4 thiosulfate sulfurtransferase YP_170642.1 1837287 D 177416 CDS YP_170643.1 56708747 3191208 1837736..1838185 1 NC_006570.2 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 1838185 secB1 3191208 secB1 Francisella tularensis subsp. tularensis SCHU S4 preprotein translocase subunit SecB YP_170643.1 1837736 D 177416 CDS YP_170644.1 56708748 3191643 1838207..1839286 1 NC_006570.2 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1839286 recA 3191643 recA Francisella tularensis subsp. tularensis SCHU S4 recombinase A YP_170644.1 1838207 D 177416 CDS YP_170645.1 56708749 3191633 1839273..1839725 1 NC_006570.2 Similar to RECX_HAEIN (P43706) Regulatory protein recX from Haemophilus influenzae (126 aa). FASTA: opt: 243 Z-score: 314.3 E(): 1.3e-09 Smith-Waterman score: 243; 31.967 identity in 122 aa overlap; regulatory protein recX 1839725 recX 3191633 recX Francisella tularensis subsp. tularensis SCHU S4 regulatory protein recX YP_170645.1 1839273 D 177416 CDS YP_170646.1 56708750 3190727 1839898..1840374 1 NC_006570.2 Similar to SSB_HAEIN P44409 Single-strand binding protein (SSB) from Haemophilus influenzae (168 aa). FASTA: opt: 437 Z-score: 543.8 E(): 1.9e-22 Smith-Waterman score: 437; 44.578identity in 166 aa overlap; single-strand binding protein 1840374 ssb 3190727 ssb Francisella tularensis subsp. tularensis SCHU S4 single-strand binding protein YP_170646.1 1839898 D 177416 CDS YP_170647.1 56708751 3190747 1840480..1841634 1 NC_006570.2 Similar to ACKA_CLOTS (Q59331) Acetate kinase (Acetokinase) from Clostridium thermosaccharolyticum (400 aa). FASTA: opt: 1204 Z-score: 1394.5 E(): 8e-70 Smith-Waterman score: 1204; 49.873 identity in 395 aa overlap; propionate kinase 1841634 tdcD 3190747 tdcD Francisella tularensis subsp. tularensis SCHU S4 propionate kinase YP_170647.1 1840480 D 177416 CDS YP_170648.1 56708752 3191229 1841644..1843740 1 NC_006570.2 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 1843740 pta 3191229 pta Francisella tularensis subsp. tularensis SCHU S4 phosphate acetyltransferase YP_170648.1 1841644 D 177416 CDS YP_170668.1 56708772 3191804 complement(join(1844748..1845206,1845206..1845532)) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1845532 isftu1 3191804 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_170668.1 1844748 R 177416 CDS YP_170650.1 56708754 3190935 complement(1846969..1847562) 1 NC_006570.2 Similar to Q8D0W2 cytochrome from Yersinia pestis (199 aa). FASTA: opt: 273 Z-score: 328.7 E(): 1.9e-10 Smith-Waterman score: 273; 27.979identity in 193 aa overlap ORF ftt1758c; B-type cytochrome 1847562 3190935 FTT_1758c Francisella tularensis subsp. tularensis SCHU S4 B-type cytochrome YP_170650.1 1846969 R 177416 CDS YP_170651.1 56708755 3191689 1848530..1849681 1 NC_006570.2 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 1849681 nhaA 3191689 nhaA Francisella tularensis subsp. tularensis SCHU S4 pH-dependent sodium/proton antiporter YP_170651.1 1848530 D 177416 CDS YP_170652.1 56708756 3191889 1849746..1850465 1 NC_006570.2 Similar to YAFD_ECOLI (P30865) Hypothetical protein yafD from E. coli (266 aa). FASTA: opt: 320 Z-score: 403.2 E(): 1.5e-14 Smith-Waterman score: 320; 34.498 identity in 229 aa overlap ORF ftt1761; hypothetical protein 1850465 3191889 FTT_1761 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170652.1 1849746 D 177416 CDS YP_170653.1 56708757 3190934 complement(1850471..1851211) 1 NC_006570.2 Similar to Q9F728 N-acylhomoserine lactone synthase from Pseudomonas fluorescens (259 aa). FASTA: opt: 408 Z-score: 521.4 E(): 3.8e-21 Smith-Waterman score: 408; 34.498 identity in 229 aa overlap ORF ftt1762c; acetyltransferase 1851211 3190934 FTT_1762c Francisella tularensis subsp. tularensis SCHU S4 acetyltransferase YP_170653.1 1850471 R 177416 CDS YP_170654.1 56708758 3190865 complement(1851225..1851977) 1 NC_006570.2 Similar to Q9F728 N-acylhomoserine lactone syntase from Pseudomonas fluorescens (259 aa). FASTA: opt: 442 Z-score: 546.9 E(): 1.4e-22 Smith-Waterman score: 442; 37.963 identity in 216 aa overlap. ORF ftt1763c; acetyltransferase 1851977 3190865 FTT_1763c Francisella tularensis subsp. tularensis SCHU S4 acetyltransferase YP_170654.1 1851225 R 177416 CDS YP_170655.1 56708759 3190855 complement(1852140..1852463) 1 NC_006570.2 Similar to FER_PSEST (P08811) Ferredoxin from Pseudomonas stutzeri (106 aa). FASTA: opt: 535 Z-score: 674.6 E(): 1.1e-29 Smith-Waterman score: 535; 65.714identity in 105 aa overlap ORF ftt1764c; ferredoxin 1852463 3190855 FTT_1764c Francisella tularensis subsp. tularensis SCHU S4 ferredoxin YP_170655.1 1852140 R 177416 CDS YP_170656.1 56708760 3190854 1852683..1853336 1 NC_006570.2 ORF ftt1765; hypothetical protein 1853336 3190854 FTT_1765 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170656.1 1852683 D 177416 CDS YP_170657.1 56708761 3190939 1853414..1854070 1 NC_006570.2 Similar to Q8YLW7 O-methyltransferase from Anabaena sp. (220 aa). FASTA: opt: 622 Z-score: 791.6 E(): 3.4e-36 Smith-Waterman score: 622; 43.836identity in 219 aa overlap ORF ftt1766; O-methyltransferase 1854070 3190939 FTT_1766 Francisella tularensis subsp. tularensis SCHU S4 O-methyltransferase YP_170657.1 1853414 D 177416 CDS YP_170658.1 56708762 3191662 complement(1854072..1855232) 1 NC_006570.2 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 1855232 purT 3191662 purT Francisella tularensis subsp. tularensis SCHU S4 phosphoribosylglycinamide formyltransferase 2 YP_170658.1 1854072 R 177416 CDS YP_170659.1 56708763 3190860 complement(1855286..1857106) 1 NC_006570.2 Similar to Q9KQP6 Chitinase from Vibrio cholerae (846 aa). FASTA: opt: 242 Z-score: 272.3 E(): 2.8e-07 Smith-Waterman score: 279; 21.309 identity in 718 aa overlap. ORF ftt1768c; chitinase 1857106 3190860 FTT_1768c Francisella tularensis subsp. tularensis SCHU S4 chitinase YP_170659.1 1855286 R 177416 CDS YP_170660.1 56708764 3192509 complement(1857728..1860307) 1 NC_006570.2 Similar to FASTA: AAO89660 (Q83F55) ClpB protein from Coxiella burnetii (859 aa). FASTA: opt: 3593 Z-score: 3223.6 E(): 1.1e-171 Smith-Waterman score: 3593; 65.357 identity in 840 aa overlap; ClpB protein 1860307 clpB 3192509 clpB Francisella tularensis subsp. tularensis SCHU S4 ClpB protein YP_170660.1 1857728 R 177416 CDS YP_170661.1 56708765 3192304 1861326..1861679 1 NC_006570.2 ORF ftt1771; hypothetical protein 1861679 3192304 FTT_1771 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170661.1 1861326 D 177416 CDS YP_170662.1 56708766 3190980 complement(1861734..1862543) 1 NC_006570.2 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1862543 trpA 3190980 trpA Francisella tularensis subsp. tularensis SCHU S4 tryptophan synthase subunit alpha YP_170662.1 1861734 R 177416 CDS YP_170663.1 56708767 3190984 complement(1862543..1863733) 1 NC_006570.2 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1863733 trpB 3190984 trpB Francisella tularensis subsp. tularensis SCHU S4 tryptophan synthase subunit beta YP_170663.1 1862543 R 177416 CDS YP_170664.1 56708768 3191542 complement(1865149..1866678) 1 NC_006570.2 Similar to CLCA_ECOLI (P37019) Voltage-gated ClC-type chloride channel from E. coli (473 aa). FASTA: opt: 1120 Z-score: 1211.7 E(): 1.3e-59 Smith-Waterman score: 1120; 39.545 identity in 440 aa overlap; voltage-gated ClC-type chloride channel clcA 1866678 clcA 3191542 clcA Francisella tularensis subsp. tularensis SCHU S4 voltage-gated ClC-type chloride channel clcA YP_170664.1 1865149 R 177416 CDS YP_170665.1 56708769 3190853 complement(1866749..1867147) 1 NC_006570.2 ORF ftt1776c; hypothetical protein 1867147 3190853 FTT_1776c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170665.1 1866749 R 177416 CDS YP_170666.1 56708770 3192294 complement(1867150..1867560) 1 NC_006570.2 ORF ftt1777c; hypothetical protein 1867560 3192294 FTT_1777c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170666.1 1867150 R 177416 CDS YP_170667.1 56708771 3190801 complement(1867581..1867973) 1 NC_006570.2 ORF ftt1778c; hypothetical protein 1867973 3190801 FTT_1778c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170667.1 1867581 R 177416 CDS YP_003097807.1 255961469 3190923 join(1868806..1869132,1869132..1869590) 1 NC_006570.2 ISFtu1. Transposase, member of the IS630 Tc-1 mariner family. Identical to Q93EJ6 transposase from Francisella tularensis (118 aa) from aa 144-261. Identical to Q93EJ7 transposase from Francisella tularensis (126 aa) from aa 1-109. Q93EJ6 and Q93EJ7 previously characterised as two separate ORF's. ORF1 (identical to Q93EJ7) contains a programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3' at aa position 109 which permits frameshifting to ORF2 (identical to Q93EJ6) to produce a single ORF. Alignment of this single ORF with additional members of the IS630 family, and also mariner elements, show that this transposase shares strongly conserved residues, including a fully conserved dipeptide,Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if ribosomal frameshifting occurs.; transposase 1869590 isftu1 3190923 isftu1 Francisella tularensis subsp. tularensis SCHU S4 transposase YP_003097807.1 1868806 D 177416 CDS YP_170669.1 56708773 3190804 complement(1869829..1870578) 1 NC_006570.2 ORF ftt1781c; hypothetical protein 1870578 3190804 FTT_1781c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170669.1 1869829 R 177416 CDS YP_170670.1 56708774 3192393 complement(1870520..1872199) 1 NC_006570.2 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 1872199 yjjK 3192393 yjjK Francisella tularensis subsp. tularensis SCHU S4 ABC transporter ATP-binding protein YP_170670.1 1870520 R 177416 CDS YP_170671.1 56708775 3190882 1872367..1873653 1 NC_006570.2 Similar to Q83A52 Major facilitator family transporter from Coxiella burnetii (443 aa). FASTA: opt: 751 Z-score: 809.6 E(): 3.3e-37 Smith-Waterman score: 751; 34.204identity in 421 aa overlap ORF ftt1783; major facilitator transporter 1873653 3190882 FTT_1783 Francisella tularensis subsp. tularensis SCHU S4 major facilitator transporter YP_170671.1 1872367 D 177416 CDS YP_170672.1 56708776 3191772 complement(1873634..1873942) 1 NC_006570.2 ORF ftt1784c; hypothetical protein 1873942 3191772 FTT_1784c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170672.1 1873634 R 177416 CDS YP_170673.1 56708777 3191779 complement(1873954..1874166) 1 NC_006570.2 ORF ftt1785c; hypothetical protein 1874166 3191779 FTT_1785c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170673.1 1873954 R 177416 CDS YP_170674.1 56708778 3191282 complement(1875200..1875811) 1 NC_006570.2 Similar to Q8UGV8 LysE family transporter from Agrobactium tumifaciens (202 aa). FASTA: opt: 346 Z-score: 414.9 E(): 3.2e-15 Smith-Waterman score: 346; 30.102 identity in 196 aa overlap ORF ftt1787c; amino acid transporter LysE 1875811 3191282 FTT_1787c Francisella tularensis subsp. tularensis SCHU S4 amino acid transporter LysE YP_170674.1 1875200 R 177416 CDS YP_170675.1 56708779 3191776 1877112..1877906 1 NC_006570.2 Similar to Q83C04 Membrane protein, , from Coxiella burnetii (263 aa). FASTA: opt: 496 Z-score: 540.4 E(): 3.3e-22 Smith-Waterman score: 496; 30.038 identity in 263 aa overlap ORF ftt1789; hypothetical protein 1877906 3191776 FTT_1789 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170675.1 1877112 D 177416 CDS YP_170676.1 56708780 3191780 1878315..1878677 1 NC_006570.2 ORF ftt1791; hypothetical protein 1878677 3191780 FTT_1791 Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170676.1 1878315 D 177416 CDS YP_170677.1 56708781 3191327 complement(1879809..1882403) 1 NC_006570.2 Similar to AMPN_ECOLI (P04825) Aminopeptidase N from E. coli (869 aa). FASTA: opt: 2226 Z-score: 2532.9 E(): 3.4e-133 Smith-Waterman score: 2751; 48.856identity in 874 aa overlap; aminopeptidase 1882403 pepN 3191327 pepN Francisella tularensis subsp. tularensis SCHU S4 aminopeptidase YP_170677.1 1879809 R 177416 CDS YP_170678.1 56708782 3192536 1882587..1883015 1 NC_006570.2 Similar to Q9WYK7 Heat shock protein, class I from Thermatoga maritima (147 aa). FASTA: opt: 288 Z-score: 346.4 E(): 2.1e-11 Smith-Waterman score: 288; 37.879 identity in 132 aa overlap ORF ftt1794; heat shock protein 1883015 3192536 FTT_1794 Francisella tularensis subsp. tularensis SCHU S4 heat shock protein YP_170678.1 1882587 D 177416 CDS YP_170679.1 56708783 3190977 complement(1883012..1884373) 1 NC_006570.2 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1884373 trpC 3190977 trpC Francisella tularensis subsp. tularensis SCHU S4 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_170679.1 1883012 R 177416 CDS YP_170680.1 56708784 3191782 complement(1884464..1884877) 1 NC_006570.2 Similar to Q9KF27 Hypothetical protein BH0670 from Bacillus halodurans (159 aa). FASTA: opt: 208 Z-score: 278.0 E(): 1.4e-07 Smith-Waterman score: 208; 28.682 identity in 129 aa overlap ORF ftt1796c; hypothetical protein 1884877 3191782 FTT_1796c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170680.1 1884464 R 177416 CDS YP_170681.1 56708785 3191678 complement(1884882..1885571) 1 NC_006570.2 Similar to MSA2_CAUCR (Q9A9E9) Peptide methionine sulfoxide reductase from Caulobacter crescentus (196 aa). FASTA opt: 510 Z-score: 598.2 E(): 2e-25 Smith-Waterman score: 510; 39.024 identity in 205 aa overlap; peptide methionine sulfoxide reductase 1885571 msrA2 3191678 msrA2 Francisella tularensis subsp. tularensis SCHU S4 peptide methionine sulfoxide reductase YP_170681.1 1884882 R 177416 CDS YP_170682.1 56708786 3192283 complement(1885655..1886023) 1 NC_006570.2 ORF ftt1798c; hypothetical protein 1886023 3192283 FTT_1798c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170682.1 1885655 R 177416 CDS YP_170683.1 56708787 3191269 complement(1886426..1886878) 1 NC_006570.2 ORF ftt1800c; hypothetical protein 1886878 3191269 FTT_1800c Francisella tularensis subsp. tularensis SCHU S4 hypothetical protein YP_170683.1 1886426 R 177416 CDS YP_008492919.1 537470122 3190987 complement(1886940..1887965) 1 NC_006570.2 anthranilate phosphoribosyltransferase 1887965 3190987 FTT_1801c Francisella tularensis subsp. tularensis SCHU S4 anthranilate phosphoribosyltransferase YP_008492919.1 1886940 R 177416 CDS YP_008492920.1 537470123 16744733 complement(1887950..1888528) 1 NC_006570.2 anthranilate synthase subunit II 1888528 16744733 ST1801a Francisella tularensis subsp. tularensis SCHU S4 anthranilate synthase subunit II YP_008492920.1 1887950 R 177416 CDS YP_170684.1 56708788 3190982 complement(1888532..1890076) 1 NC_006570.2 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase subunit I 1890076 trpE 3190982 trpE Francisella tularensis subsp. tularensis SCHU S4 anthranilate synthase subunit I YP_170684.1 1888532 R 177416 CDS YP_170685.1 56708789 3190986 complement(1890085..1890372) 1 NC_006570.2 Similar to TRPR_ECOLI (P03032) Trp operon repressor from E. coli (107 aa). FASTA: opt: 175 Z-score: 239.1 E(): 2e-05 Smith-Waterman score: 175; 32.584 identity in 89 aa overlap; trp operon repressor 1890372 trpR 3190986 trpR Francisella tularensis subsp. tularensis SCHU S4 trp operon repressor YP_170685.1 1890085 R 177416 CDS YP_170686.1 56708790 3191606 complement(1890846..1892342) 1 NC_006570.2 Similar to RNG_ECOLI (P25537) Ribonuclease G from E. coli (488 aa). FASTA: opt: 1439 Z-score: 1642.1 E(): 1.4e-83 Smith-Waterman score: 1439; 45.418 identity in 491 aa overlap; ribonuclease G 1892342 rng 3191606 rng Francisella tularensis subsp. tularensis SCHU S4 ribonuclease G YP_170686.1 1890846 R 177416 CDS