-- dump date 20140619_095604 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1001534000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1001534000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1001534000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001534000004 Walker A motif; other site 1001534000005 ATP binding site [chemical binding]; other site 1001534000006 Walker B motif; other site 1001534000007 arginine finger; other site 1001534000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1001534000009 DnaA box-binding interface [nucleotide binding]; other site 1001534000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1001534000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1001534000012 putative DNA binding surface [nucleotide binding]; other site 1001534000013 dimer interface [polypeptide binding]; other site 1001534000014 beta-clamp/clamp loader binding surface; other site 1001534000015 beta-clamp/translesion DNA polymerase binding surface; other site 1001534000016 metabolite-proton symporter; Region: 2A0106; TIGR00883 1001534000017 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1001534000018 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1001534000019 dimer interface [polypeptide binding]; other site 1001534000020 anticodon binding site; other site 1001534000021 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1001534000022 homodimer interface [polypeptide binding]; other site 1001534000023 motif 1; other site 1001534000024 active site 1001534000025 motif 2; other site 1001534000026 GAD domain; Region: GAD; pfam02938 1001534000027 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1001534000028 active site 1001534000029 motif 3; other site 1001534000030 adenylosuccinate lyase; Provisional; Region: PRK07492 1001534000031 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1001534000032 tetramer interface [polypeptide binding]; other site 1001534000033 active site 1001534000034 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1001534000035 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1001534000036 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1001534000037 HlyD family secretion protein; Region: HlyD_3; pfam13437 1001534000038 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 1001534000039 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1001534000040 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1001534000041 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1001534000042 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1001534000043 GatB domain; Region: GatB_Yqey; smart00845 1001534000044 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1001534000045 oxyanion hole [active] 1001534000046 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1001534000047 catalytic triad [active] 1001534000048 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 1001534000049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534000050 putative substrate translocation pore; other site 1001534000051 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1001534000052 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 1001534000053 dimer interface [polypeptide binding]; other site 1001534000054 active site 1001534000055 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1001534000056 catalytic residues [active] 1001534000057 substrate binding site [chemical binding]; other site 1001534000058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001534000059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534000060 IucA / IucC family; Region: IucA_IucC; pfam04183 1001534000061 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1001534000062 ferric uptake regulator; Provisional; Region: fur; PRK09462 1001534000063 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1001534000064 metal binding site 2 [ion binding]; metal-binding site 1001534000065 putative DNA binding helix; other site 1001534000066 metal binding site 1 [ion binding]; metal-binding site 1001534000067 dimer interface [polypeptide binding]; other site 1001534000068 structural Zn2+ binding site [ion binding]; other site 1001534000069 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1001534000070 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1001534000071 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1001534000072 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1001534000073 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1001534000074 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1001534000075 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1001534000076 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1001534000077 putative dimer interface [polypeptide binding]; other site 1001534000078 [2Fe-2S] cluster binding site [ion binding]; other site 1001534000079 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1001534000080 SLBB domain; Region: SLBB; pfam10531 1001534000081 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1001534000082 NADH dehydrogenase subunit G; Validated; Region: PRK09129 1001534000083 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1001534000084 catalytic loop [active] 1001534000085 iron binding site [ion binding]; other site 1001534000086 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1001534000087 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 1001534000088 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1001534000089 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1001534000090 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1001534000091 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1001534000092 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1001534000093 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1001534000094 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1001534000095 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1001534000096 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1001534000097 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1001534000098 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1001534000099 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1001534000100 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1001534000101 Membrane fusogenic activity; Region: BMFP; pfam04380 1001534000102 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1001534000103 substrate binding site [chemical binding]; other site 1001534000104 active site 1001534000105 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1001534000106 hypothetical protein; Provisional; Region: PRK14641 1001534000107 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1001534000108 putative oligomer interface [polypeptide binding]; other site 1001534000109 putative RNA binding site [nucleotide binding]; other site 1001534000110 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1001534000111 NusA N-terminal domain; Region: NusA_N; pfam08529 1001534000112 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1001534000113 RNA binding site [nucleotide binding]; other site 1001534000114 homodimer interface [polypeptide binding]; other site 1001534000115 NusA-like KH domain; Region: KH_5; pfam13184 1001534000116 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1001534000117 G-X-X-G motif; other site 1001534000118 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1001534000119 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1001534000120 translation initiation factor IF-2; Region: IF-2; TIGR00487 1001534000121 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1001534000122 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1001534000123 G1 box; other site 1001534000124 putative GEF interaction site [polypeptide binding]; other site 1001534000125 GTP/Mg2+ binding site [chemical binding]; other site 1001534000126 Switch I region; other site 1001534000127 G2 box; other site 1001534000128 G3 box; other site 1001534000129 Switch II region; other site 1001534000130 G4 box; other site 1001534000131 G5 box; other site 1001534000132 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1001534000133 Translation-initiation factor 2; Region: IF-2; pfam11987 1001534000134 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1001534000135 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1001534000136 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1001534000137 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1001534000138 dimer interface [polypeptide binding]; other site 1001534000139 motif 1; other site 1001534000140 active site 1001534000141 motif 2; other site 1001534000142 motif 3; other site 1001534000143 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1001534000144 anticodon binding site; other site 1001534000145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534000146 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1001534000147 putative substrate translocation pore; other site 1001534000148 Predicted ATPase [General function prediction only]; Region: COG1485 1001534000149 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1001534000150 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001534000151 RNA binding surface [nucleotide binding]; other site 1001534000152 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1001534000153 active site 1001534000154 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001534000155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534000156 putative substrate translocation pore; other site 1001534000157 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1001534000158 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1001534000159 F0F1 ATP synthase subunit C; Provisional; Region: PRK13464 1001534000160 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1001534000161 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1001534000162 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1001534000163 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1001534000164 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1001534000165 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1001534000166 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1001534000167 beta subunit interaction interface [polypeptide binding]; other site 1001534000168 Walker A motif; other site 1001534000169 ATP binding site [chemical binding]; other site 1001534000170 Walker B motif; other site 1001534000171 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1001534000172 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1001534000173 core domain interface [polypeptide binding]; other site 1001534000174 delta subunit interface [polypeptide binding]; other site 1001534000175 epsilon subunit interface [polypeptide binding]; other site 1001534000176 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1001534000177 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1001534000178 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1001534000179 alpha subunit interaction interface [polypeptide binding]; other site 1001534000180 Walker A motif; other site 1001534000181 ATP binding site [chemical binding]; other site 1001534000182 Walker B motif; other site 1001534000183 inhibitor binding site; inhibition site 1001534000184 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1001534000185 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 1001534000186 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1001534000187 gamma subunit interface [polypeptide binding]; other site 1001534000188 epsilon subunit interface [polypeptide binding]; other site 1001534000189 LBP interface [polypeptide binding]; other site 1001534000190 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1001534000191 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1001534000192 putative active site [active] 1001534000193 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1001534000194 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1001534000195 putative GSH binding site [chemical binding]; other site 1001534000196 catalytic residues [active] 1001534000197 superoxide dismutase; Provisional; Region: PRK10543 1001534000198 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1001534000199 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1001534000200 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1001534000201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534000202 putative substrate translocation pore; other site 1001534000203 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1001534000204 dimer interface [polypeptide binding]; other site 1001534000205 Citrate synthase; Region: Citrate_synt; pfam00285 1001534000206 active site 1001534000207 citrylCoA binding site [chemical binding]; other site 1001534000208 NADH binding [chemical binding]; other site 1001534000209 cationic pore residues; other site 1001534000210 oxalacetate/citrate binding site [chemical binding]; other site 1001534000211 coenzyme A binding site [chemical binding]; other site 1001534000212 catalytic triad [active] 1001534000213 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1001534000214 Iron-sulfur protein interface; other site 1001534000215 proximal quinone binding site [chemical binding]; other site 1001534000216 SdhD (CybS) interface [polypeptide binding]; other site 1001534000217 proximal heme binding site [chemical binding]; other site 1001534000218 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1001534000219 SdhC subunit interface [polypeptide binding]; other site 1001534000220 proximal heme binding site [chemical binding]; other site 1001534000221 cardiolipin binding site; other site 1001534000222 Iron-sulfur protein interface; other site 1001534000223 proximal quinone binding site [chemical binding]; other site 1001534000224 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1001534000225 L-aspartate oxidase; Provisional; Region: PRK06175 1001534000226 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1001534000227 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1001534000228 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1001534000229 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1001534000230 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1001534000231 TPP-binding site [chemical binding]; other site 1001534000232 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1001534000233 dimer interface [polypeptide binding]; other site 1001534000234 PYR/PP interface [polypeptide binding]; other site 1001534000235 TPP binding site [chemical binding]; other site 1001534000236 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1001534000237 E3 interaction surface; other site 1001534000238 lipoyl attachment site [posttranslational modification]; other site 1001534000239 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1001534000240 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1001534000241 E3 interaction surface; other site 1001534000242 lipoyl attachment site [posttranslational modification]; other site 1001534000243 e3 binding domain; Region: E3_binding; pfam02817 1001534000244 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1001534000245 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1001534000246 nucleotide binding site [chemical binding]; other site 1001534000247 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001534000248 active site 1001534000249 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 1001534000250 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1001534000251 active site 1001534000252 substrate binding site [chemical binding]; other site 1001534000253 metal binding site [ion binding]; metal-binding site 1001534000254 triosephosphate isomerase; Provisional; Region: PRK14567 1001534000255 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1001534000256 substrate binding site [chemical binding]; other site 1001534000257 dimer interface [polypeptide binding]; other site 1001534000258 catalytic triad [active] 1001534000259 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1001534000260 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1001534000261 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1001534000262 HemN family oxidoreductase; Provisional; Region: PRK05660 1001534000263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001534000264 FeS/SAM binding site; other site 1001534000265 HemN C-terminal domain; Region: HemN_C; pfam06969 1001534000266 Predicted membrane protein [Function unknown]; Region: COG2246 1001534000267 GtrA-like protein; Region: GtrA; pfam04138 1001534000268 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1001534000269 aconitate hydratase; Validated; Region: PRK09277 1001534000270 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1001534000271 substrate binding site [chemical binding]; other site 1001534000272 ligand binding site [chemical binding]; other site 1001534000273 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1001534000274 substrate binding site [chemical binding]; other site 1001534000275 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1001534000276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001534000277 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1001534000278 Walker A motif; other site 1001534000279 Walker A/P-loop; other site 1001534000280 ATP binding site [chemical binding]; other site 1001534000281 ATP binding site [chemical binding]; other site 1001534000282 Walker B motif; other site 1001534000283 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 1001534000284 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1001534000285 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1001534000286 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1001534000287 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1001534000288 putative NAD(P) binding site [chemical binding]; other site 1001534000289 putative active site [active] 1001534000290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001534000291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001534000292 dimer interface [polypeptide binding]; other site 1001534000293 phosphorylation site [posttranslational modification] 1001534000294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001534000295 ATP binding site [chemical binding]; other site 1001534000296 Mg2+ binding site [ion binding]; other site 1001534000297 G-X-G motif; other site 1001534000298 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1001534000299 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1001534000300 dimer interface [polypeptide binding]; other site 1001534000301 catalytic triad [active] 1001534000302 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1001534000303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534000304 multidrug efflux protein; Reviewed; Region: PRK09579 1001534000305 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1001534000306 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1001534000307 HlyD family secretion protein; Region: HlyD_3; pfam13437 1001534000308 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1001534000309 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 1001534000310 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1001534000311 active site 1001534000312 NTP binding site [chemical binding]; other site 1001534000313 metal binding triad [ion binding]; metal-binding site 1001534000314 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1001534000315 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1001534000316 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001534000317 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1001534000318 Walker A/P-loop; other site 1001534000319 ATP binding site [chemical binding]; other site 1001534000320 Q-loop/lid; other site 1001534000321 ABC transporter signature motif; other site 1001534000322 Walker B; other site 1001534000323 D-loop; other site 1001534000324 H-loop/switch region; other site 1001534000325 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1001534000326 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1001534000327 DNA polymerase I; Provisional; Region: PRK05755 1001534000328 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1001534000329 active site 1001534000330 metal binding site 1 [ion binding]; metal-binding site 1001534000331 putative 5' ssDNA interaction site; other site 1001534000332 metal binding site 3; metal-binding site 1001534000333 metal binding site 2 [ion binding]; metal-binding site 1001534000334 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1001534000335 putative DNA binding site [nucleotide binding]; other site 1001534000336 putative metal binding site [ion binding]; other site 1001534000337 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1001534000338 active site 1001534000339 catalytic site [active] 1001534000340 substrate binding site [chemical binding]; other site 1001534000341 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1001534000342 active site 1001534000343 DNA binding site [nucleotide binding] 1001534000344 catalytic site [active] 1001534000345 pantothenate kinase; Reviewed; Region: PRK13324 1001534000346 phosphopentomutase; Provisional; Region: PRK05362 1001534000347 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1001534000348 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1001534000349 intersubunit interface [polypeptide binding]; other site 1001534000350 active site 1001534000351 catalytic residue [active] 1001534000352 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1001534000353 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1001534000354 Nucleoside recognition; Region: Gate; pfam07670 1001534000355 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1001534000356 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1001534000357 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1001534000358 Nucleoside recognition; Region: Gate; pfam07670 1001534000359 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1001534000360 thymidylate kinase; Validated; Region: tmk; PRK00698 1001534000361 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1001534000362 TMP-binding site; other site 1001534000363 ATP-binding site [chemical binding]; other site 1001534000364 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1001534000365 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1001534000366 G1 box; other site 1001534000367 putative GEF interaction site [polypeptide binding]; other site 1001534000368 GTP/Mg2+ binding site [chemical binding]; other site 1001534000369 Switch I region; other site 1001534000370 G2 box; other site 1001534000371 G3 box; other site 1001534000372 Switch II region; other site 1001534000373 G4 box; other site 1001534000374 G5 box; other site 1001534000375 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1001534000376 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001534000377 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1001534000378 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1001534000379 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1001534000380 GTP binding site [chemical binding]; other site 1001534000381 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1001534000382 Part of AAA domain; Region: AAA_19; pfam13245 1001534000383 Family description; Region: UvrD_C_2; pfam13538 1001534000384 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1001534000385 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1001534000386 peptide binding site [polypeptide binding]; other site 1001534000387 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1001534000388 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1001534000389 Walker A/P-loop; other site 1001534000390 ATP binding site [chemical binding]; other site 1001534000391 Q-loop/lid; other site 1001534000392 ABC transporter signature motif; other site 1001534000393 Walker B; other site 1001534000394 D-loop; other site 1001534000395 H-loop/switch region; other site 1001534000396 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1001534000397 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1001534000398 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1001534000399 Walker A/P-loop; other site 1001534000400 ATP binding site [chemical binding]; other site 1001534000401 Q-loop/lid; other site 1001534000402 ABC transporter signature motif; other site 1001534000403 Walker B; other site 1001534000404 D-loop; other site 1001534000405 H-loop/switch region; other site 1001534000406 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1001534000407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534000408 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001534000409 putative substrate translocation pore; other site 1001534000410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534000411 putative substrate translocation pore; other site 1001534000412 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001534000413 glycerol kinase; Provisional; Region: glpK; PRK00047 1001534000414 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1001534000415 N- and C-terminal domain interface [polypeptide binding]; other site 1001534000416 active site 1001534000417 MgATP binding site [chemical binding]; other site 1001534000418 catalytic site [active] 1001534000419 metal binding site [ion binding]; metal-binding site 1001534000420 glycerol binding site [chemical binding]; other site 1001534000421 homotetramer interface [polypeptide binding]; other site 1001534000422 homodimer interface [polypeptide binding]; other site 1001534000423 FBP binding site [chemical binding]; other site 1001534000424 protein IIAGlc interface [polypeptide binding]; other site 1001534000425 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1001534000426 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1001534000427 amphipathic channel; other site 1001534000428 Asn-Pro-Ala signature motifs; other site 1001534000429 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1001534000430 AAA domain; Region: AAA_30; pfam13604 1001534000431 Family description; Region: UvrD_C_2; pfam13538 1001534000432 elongation factor Tu; Reviewed; Region: PRK00049 1001534000433 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1001534000434 G1 box; other site 1001534000435 GEF interaction site [polypeptide binding]; other site 1001534000436 GTP/Mg2+ binding site [chemical binding]; other site 1001534000437 Switch I region; other site 1001534000438 G2 box; other site 1001534000439 G3 box; other site 1001534000440 Switch II region; other site 1001534000441 G4 box; other site 1001534000442 G5 box; other site 1001534000443 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1001534000444 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1001534000445 Antibiotic Binding Site [chemical binding]; other site 1001534000446 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1001534000447 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1001534000448 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1001534000449 putative homodimer interface [polypeptide binding]; other site 1001534000450 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1001534000451 heterodimer interface [polypeptide binding]; other site 1001534000452 homodimer interface [polypeptide binding]; other site 1001534000453 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1001534000454 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1001534000455 23S rRNA interface [nucleotide binding]; other site 1001534000456 L7/L12 interface [polypeptide binding]; other site 1001534000457 putative thiostrepton binding site; other site 1001534000458 L25 interface [polypeptide binding]; other site 1001534000459 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1001534000460 mRNA/rRNA interface [nucleotide binding]; other site 1001534000461 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1001534000462 23S rRNA interface [nucleotide binding]; other site 1001534000463 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1001534000464 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1001534000465 core dimer interface [polypeptide binding]; other site 1001534000466 peripheral dimer interface [polypeptide binding]; other site 1001534000467 L10 interface [polypeptide binding]; other site 1001534000468 L11 interface [polypeptide binding]; other site 1001534000469 putative EF-Tu interaction site [polypeptide binding]; other site 1001534000470 putative EF-G interaction site [polypeptide binding]; other site 1001534000471 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1001534000472 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1001534000473 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1001534000474 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1001534000475 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1001534000476 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1001534000477 RPB3 interaction site [polypeptide binding]; other site 1001534000478 RPB1 interaction site [polypeptide binding]; other site 1001534000479 RPB11 interaction site [polypeptide binding]; other site 1001534000480 RPB10 interaction site [polypeptide binding]; other site 1001534000481 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1001534000482 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1001534000483 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1001534000484 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1001534000485 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1001534000486 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1001534000487 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1001534000488 cleft; other site 1001534000489 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1001534000490 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 1001534000491 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1001534000492 DNA binding site [nucleotide binding] 1001534000493 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1001534000494 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 1001534000495 UGMP family protein; Validated; Region: PRK09604 1001534000496 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1001534000497 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1001534000498 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1001534000499 Di-iron ligands [ion binding]; other site 1001534000500 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1001534000501 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1001534000502 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1001534000503 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1001534000504 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1001534000505 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1001534000506 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 1001534000507 RimM N-terminal domain; Region: RimM; pfam01782 1001534000508 PRC-barrel domain; Region: PRC; pfam05239 1001534000509 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1001534000510 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1001534000511 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1001534000512 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1001534000513 active site 1001534000514 DNA binding site [nucleotide binding] 1001534000515 Int/Topo IB signature motif; other site 1001534000516 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1001534000517 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1001534000518 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1001534000519 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 1001534000520 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1001534000521 putative active site [active] 1001534000522 Ap4A binding site [chemical binding]; other site 1001534000523 nudix motif; other site 1001534000524 putative metal binding site [ion binding]; other site 1001534000525 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1001534000526 active site 1001534000527 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1001534000528 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1001534000529 amidase catalytic site [active] 1001534000530 Zn binding residues [ion binding]; other site 1001534000531 substrate binding site [chemical binding]; other site 1001534000532 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1001534000533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001534000534 Mg2+ binding site [ion binding]; other site 1001534000535 G-X-G motif; other site 1001534000536 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1001534000537 anchoring element; other site 1001534000538 dimer interface [polypeptide binding]; other site 1001534000539 ATP binding site [chemical binding]; other site 1001534000540 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1001534000541 active site 1001534000542 metal binding site [ion binding]; metal-binding site 1001534000543 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1001534000544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534000545 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1001534000546 putative substrate translocation pore; other site 1001534000547 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1001534000548 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1001534000549 Trp docking motif [polypeptide binding]; other site 1001534000550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001534000551 TPR motif; other site 1001534000552 binding surface 1001534000553 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1001534000554 glutamyl-tRNA reductase; Provisional; Region: PRK13940 1001534000555 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1001534000556 tRNA; other site 1001534000557 putative tRNA binding site [nucleotide binding]; other site 1001534000558 putative NADP binding site [chemical binding]; other site 1001534000559 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1001534000560 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1001534000561 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1001534000562 RF-1 domain; Region: RF-1; pfam00472 1001534000563 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1001534000564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001534000565 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1001534000566 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 1001534000567 putative active site [active] 1001534000568 Zn binding site [ion binding]; other site 1001534000569 YGGT family; Region: YGGT; pfam02325 1001534000570 YGGT family; Region: YGGT; pfam02325 1001534000571 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1001534000572 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1001534000573 Walker A/P-loop; other site 1001534000574 ATP binding site [chemical binding]; other site 1001534000575 Q-loop/lid; other site 1001534000576 ABC transporter signature motif; other site 1001534000577 Walker B; other site 1001534000578 D-loop; other site 1001534000579 H-loop/switch region; other site 1001534000580 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1001534000581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001534000582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1001534000583 Coenzyme A binding pocket [chemical binding]; other site 1001534000584 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 1001534000585 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 1001534000586 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1001534000587 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1001534000588 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1001534000589 putative acyl-acceptor binding pocket; other site 1001534000590 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1001534000591 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1001534000592 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1001534000593 RNA binding site [nucleotide binding]; other site 1001534000594 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1001534000595 RNA binding site [nucleotide binding]; other site 1001534000596 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1001534000597 RNA binding site [nucleotide binding]; other site 1001534000598 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1001534000599 RNA binding site [nucleotide binding]; other site 1001534000600 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1001534000601 RNA binding site [nucleotide binding]; other site 1001534000602 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1001534000603 RNA binding site [nucleotide binding]; other site 1001534000604 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1001534000605 nucleoside/Zn binding site; other site 1001534000606 dimer interface [polypeptide binding]; other site 1001534000607 catalytic motif [active] 1001534000608 D-alanyl-alanine synthetase A; Provisional; Region: PRK14569 1001534000609 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1001534000610 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1001534000611 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1001534000612 Cell division protein FtsQ; Region: FtsQ; pfam03799 1001534000613 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1001534000614 Cell division protein FtsA; Region: FtsA; smart00842 1001534000615 Cell division protein FtsA; Region: FtsA; pfam14450 1001534000616 cell division protein FtsZ; Validated; Region: PRK09330 1001534000617 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1001534000618 nucleotide binding site [chemical binding]; other site 1001534000619 SulA interaction site; other site 1001534000620 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1001534000621 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1001534000622 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 1001534000623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001534000624 Walker A motif; other site 1001534000625 ATP binding site [chemical binding]; other site 1001534000626 Walker B motif; other site 1001534000627 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1001534000628 arginine finger; other site 1001534000629 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1001534000630 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1001534000631 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1001534000632 RF-1 domain; Region: RF-1; pfam00472 1001534000633 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1001534000634 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1001534000635 dimer interface [polypeptide binding]; other site 1001534000636 putative anticodon binding site; other site 1001534000637 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1001534000638 motif 1; other site 1001534000639 active site 1001534000640 motif 2; other site 1001534000641 motif 3; other site 1001534000642 hypothetical protein; Provisional; Region: PRK05208 1001534000643 CAAX protease self-immunity; Region: Abi; pfam02517 1001534000644 Eps15 homology domain; Region: EH; smart00027 1001534000645 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1001534000646 Glutaminase; Region: Glutaminase; cl00907 1001534000647 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1001534000648 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1001534000649 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1001534000650 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1001534000651 glutamine synthetase; Region: PLN02284 1001534000652 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1001534000653 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1001534000654 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1001534000655 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1001534000656 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1001534000657 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1001534000658 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1001534000659 purine monophosphate binding site [chemical binding]; other site 1001534000660 dimer interface [polypeptide binding]; other site 1001534000661 putative catalytic residues [active] 1001534000662 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1001534000663 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1001534000664 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1001534000665 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1001534000666 GDP-binding site [chemical binding]; other site 1001534000667 ACT binding site; other site 1001534000668 IMP binding site; other site 1001534000669 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001534000670 active site 1001534000671 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1001534000672 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1001534000673 dimer interface [polypeptide binding]; other site 1001534000674 putative PBP binding regions; other site 1001534000675 ABC-ATPase subunit interface; other site 1001534000676 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1001534000677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001534000678 Walker A/P-loop; other site 1001534000679 ATP binding site [chemical binding]; other site 1001534000680 Q-loop/lid; other site 1001534000681 ABC transporter signature motif; other site 1001534000682 Walker B; other site 1001534000683 D-loop; other site 1001534000684 H-loop/switch region; other site 1001534000685 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1001534000686 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1001534000687 intersubunit interface [polypeptide binding]; other site 1001534000688 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1001534000689 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1001534000690 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1001534000691 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1001534000692 primosome assembly protein PriA; Validated; Region: PRK05580 1001534000693 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001534000694 ATP binding site [chemical binding]; other site 1001534000695 putative Mg++ binding site [ion binding]; other site 1001534000696 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1001534000697 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1001534000698 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1001534000699 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1001534000700 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1001534000701 LamB/YcsF family protein; Provisional; Region: PRK05406 1001534000702 metabolite-proton symporter; Region: 2A0106; TIGR00883 1001534000703 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1001534000704 catalytic site [active] 1001534000705 putative active site [active] 1001534000706 putative substrate binding site [chemical binding]; other site 1001534000707 dimer interface [polypeptide binding]; other site 1001534000708 elongation factor P; Validated; Region: PRK00529 1001534000709 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1001534000710 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1001534000711 RNA binding site [nucleotide binding]; other site 1001534000712 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1001534000713 RNA binding site [nucleotide binding]; other site 1001534000714 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1001534000715 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1001534000716 putative acyl-acceptor binding pocket; other site 1001534000717 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1001534000718 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1001534000719 putative acyl-acceptor binding pocket; other site 1001534000720 membrane protein insertase; Provisional; Region: PRK01318 1001534000721 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1001534000722 hypothetical protein; Provisional; Region: PRK14375 1001534000723 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1001534000724 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1001534000725 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1001534000726 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1001534000727 shikimate binding site; other site 1001534000728 NAD(P) binding site [chemical binding]; other site 1001534000729 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1001534000730 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1001534000731 NAD(P) binding site [chemical binding]; other site 1001534000732 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001534000733 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001534000734 Predicted methyltransferases [General function prediction only]; Region: COG0313 1001534000735 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1001534000736 putative SAM binding site [chemical binding]; other site 1001534000737 putative homodimer interface [polypeptide binding]; other site 1001534000738 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1001534000739 Mitochondrial PGP phosphatase; Region: PGP_phosphatase; pfam09419 1001534000740 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1001534000741 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1001534000742 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1001534000743 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1001534000744 PLD-like domain; Region: PLDc_2; pfam13091 1001534000745 putative homodimer interface [polypeptide binding]; other site 1001534000746 putative active site [active] 1001534000747 catalytic site [active] 1001534000748 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1001534000749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001534000750 ATP binding site [chemical binding]; other site 1001534000751 putative Mg++ binding site [ion binding]; other site 1001534000752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001534000753 nucleotide binding region [chemical binding]; other site 1001534000754 ATP-binding site [chemical binding]; other site 1001534000755 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1001534000756 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1001534000757 Ligand Binding Site [chemical binding]; other site 1001534000758 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1001534000759 Ligand Binding Site [chemical binding]; other site 1001534000760 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1001534000761 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1001534000762 G1 box; other site 1001534000763 GTP/Mg2+ binding site [chemical binding]; other site 1001534000764 Switch I region; other site 1001534000765 G2 box; other site 1001534000766 G3 box; other site 1001534000767 Switch II region; other site 1001534000768 G4 box; other site 1001534000769 G5 box; other site 1001534000770 Nucleoside recognition; Region: Gate; pfam07670 1001534000771 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1001534000772 Nucleoside recognition; Region: Gate; pfam07670 1001534000773 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1001534000774 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1001534000775 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1001534000776 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1001534000777 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1001534000778 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1001534000779 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1001534000780 homodimer interface [polypeptide binding]; other site 1001534000781 substrate-cofactor binding pocket; other site 1001534000782 catalytic residue [active] 1001534000783 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1001534000784 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1001534000785 active site 1001534000786 catalytic residues [active] 1001534000787 metal binding site [ion binding]; metal-binding site 1001534000788 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 1001534000789 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1001534000790 RNB domain; Region: RNB; pfam00773 1001534000791 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1001534000792 putative hydrolase; Provisional; Region: PRK11460 1001534000793 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1001534000794 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1001534000795 domain interfaces; other site 1001534000796 active site 1001534000797 camphor resistance protein CrcB; Provisional; Region: PRK14226 1001534000798 Zinc-finger domain; Region: zf-CHCC; cl01821 1001534000799 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1001534000800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001534000801 dimer interface [polypeptide binding]; other site 1001534000802 conserved gate region; other site 1001534000803 putative PBP binding loops; other site 1001534000804 ABC-ATPase subunit interface; other site 1001534000805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001534000806 dimer interface [polypeptide binding]; other site 1001534000807 conserved gate region; other site 1001534000808 putative PBP binding loops; other site 1001534000809 ABC-ATPase subunit interface; other site 1001534000810 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1001534000811 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1001534000812 Walker A/P-loop; other site 1001534000813 ATP binding site [chemical binding]; other site 1001534000814 Q-loop/lid; other site 1001534000815 ABC transporter signature motif; other site 1001534000816 Walker B; other site 1001534000817 D-loop; other site 1001534000818 H-loop/switch region; other site 1001534000819 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1001534000820 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 1001534000821 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1001534000822 TrkA-N domain; Region: TrkA_N; pfam02254 1001534000823 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1001534000824 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1001534000825 trimer interface [polypeptide binding]; other site 1001534000826 putative metal binding site [ion binding]; other site 1001534000827 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1001534000828 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1001534000829 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1001534000830 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1001534000831 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1001534000832 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1001534000833 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1001534000834 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1001534000835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534000836 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001534000837 putative substrate translocation pore; other site 1001534000838 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1001534000839 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1001534000840 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1001534000841 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1001534000842 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1001534000843 D-pathway; other site 1001534000844 Putative ubiquinol binding site [chemical binding]; other site 1001534000845 Low-spin heme (heme b) binding site [chemical binding]; other site 1001534000846 Putative water exit pathway; other site 1001534000847 Binuclear center (heme o3/CuB) [ion binding]; other site 1001534000848 K-pathway; other site 1001534000849 Putative proton exit pathway; other site 1001534000850 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1001534000851 Subunit I/III interface [polypeptide binding]; other site 1001534000852 Subunit III/IV interface [polypeptide binding]; other site 1001534000853 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1001534000854 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1001534000855 UbiA prenyltransferase family; Region: UbiA; pfam01040 1001534000856 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1001534000857 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1001534000858 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1001534000859 trimer interface [polypeptide binding]; other site 1001534000860 active site 1001534000861 UDP-GlcNAc binding site [chemical binding]; other site 1001534000862 lipid binding site [chemical binding]; lipid-binding site 1001534000863 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 1001534000864 pyridoxamine kinase; Validated; Region: PRK05756 1001534000865 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1001534000866 dimer interface [polypeptide binding]; other site 1001534000867 pyridoxal binding site [chemical binding]; other site 1001534000868 ATP binding site [chemical binding]; other site 1001534000869 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1001534000870 MoxR-like ATPases [General function prediction only]; Region: COG0714 1001534000871 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 1001534000872 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1001534000873 Protein of unknown function DUF58; Region: DUF58; pfam01882 1001534000874 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1001534000875 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1001534000876 metal ion-dependent adhesion site (MIDAS); other site 1001534000877 Oxygen tolerance; Region: BatD; pfam13584 1001534000878 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1001534000879 putative substrate binding pocket [chemical binding]; other site 1001534000880 AC domain interface; other site 1001534000881 catalytic triad [active] 1001534000882 AB domain interface; other site 1001534000883 interchain disulfide; other site 1001534000884 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 1001534000885 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1001534000886 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1001534000887 HIGH motif; other site 1001534000888 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1001534000889 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1001534000890 active site 1001534000891 KMSKS motif; other site 1001534000892 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1001534000893 tRNA binding surface [nucleotide binding]; other site 1001534000894 anticodon binding site; other site 1001534000895 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1001534000896 1-deoxy-D-xylulose-5-phosphate synthase; Region: PLN02225 1001534000897 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1001534000898 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1001534000899 phosphate binding site [ion binding]; other site 1001534000900 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1001534000901 dimer interface [polypeptide binding]; other site 1001534000902 FMN binding site [chemical binding]; other site 1001534000903 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1001534000904 nudix motif; other site 1001534000905 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1001534000906 Class II fumarases; Region: Fumarase_classII; cd01362 1001534000907 active site 1001534000908 tetramer interface [polypeptide binding]; other site 1001534000909 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1001534000910 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1001534000911 HIGH motif; other site 1001534000912 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1001534000913 active site 1001534000914 KMSKS motif; other site 1001534000915 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1001534000916 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 1001534000917 Amidinotransferase; Region: Amidinotransf; pfam02274 1001534000918 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1001534000919 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1001534000920 folate binding site [chemical binding]; other site 1001534000921 NADP+ binding site [chemical binding]; other site 1001534000922 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1001534000923 rRNA interaction site [nucleotide binding]; other site 1001534000924 S8 interaction site; other site 1001534000925 putative laminin-1 binding site; other site 1001534000926 elongation factor Ts; Provisional; Region: tsf; PRK09377 1001534000927 UBA/TS-N domain; Region: UBA; pfam00627 1001534000928 Elongation factor TS; Region: EF_TS; pfam00889 1001534000929 Elongation factor TS; Region: EF_TS; pfam00889 1001534000930 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1001534000931 putative nucleotide binding site [chemical binding]; other site 1001534000932 uridine monophosphate binding site [chemical binding]; other site 1001534000933 homohexameric interface [polypeptide binding]; other site 1001534000934 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1001534000935 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1001534000936 hinge region; other site 1001534000937 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 1001534000938 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1001534000939 catalytic residue [active] 1001534000940 putative FPP diphosphate binding site; other site 1001534000941 putative FPP binding hydrophobic cleft; other site 1001534000942 dimer interface [polypeptide binding]; other site 1001534000943 putative IPP diphosphate binding site; other site 1001534000944 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1001534000945 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1001534000946 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1001534000947 trimer interface [polypeptide binding]; other site 1001534000948 active site 1001534000949 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1001534000950 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1001534000951 S17 interaction site [polypeptide binding]; other site 1001534000952 S8 interaction site; other site 1001534000953 16S rRNA interaction site [nucleotide binding]; other site 1001534000954 streptomycin interaction site [chemical binding]; other site 1001534000955 23S rRNA interaction site [nucleotide binding]; other site 1001534000956 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1001534000957 30S ribosomal protein S7; Validated; Region: PRK05302 1001534000958 elongation factor G; Reviewed; Region: PRK00007 1001534000959 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1001534000960 G1 box; other site 1001534000961 putative GEF interaction site [polypeptide binding]; other site 1001534000962 GTP/Mg2+ binding site [chemical binding]; other site 1001534000963 Switch I region; other site 1001534000964 G2 box; other site 1001534000965 G3 box; other site 1001534000966 Switch II region; other site 1001534000967 G4 box; other site 1001534000968 G5 box; other site 1001534000969 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1001534000970 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1001534000971 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1001534000972 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1001534000973 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1001534000974 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1001534000975 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1001534000976 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1001534000977 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1001534000978 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1001534000979 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1001534000980 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1001534000981 putative translocon binding site; other site 1001534000982 protein-rRNA interface [nucleotide binding]; other site 1001534000983 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1001534000984 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1001534000985 G-X-X-G motif; other site 1001534000986 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1001534000987 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1001534000988 23S rRNA interface [nucleotide binding]; other site 1001534000989 5S rRNA interface [nucleotide binding]; other site 1001534000990 putative antibiotic binding site [chemical binding]; other site 1001534000991 L25 interface [polypeptide binding]; other site 1001534000992 L27 interface [polypeptide binding]; other site 1001534000993 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1001534000994 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1001534000995 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1001534000996 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1001534000997 RNA binding site [nucleotide binding]; other site 1001534000998 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1001534000999 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1001534001000 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1001534001001 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1001534001002 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1001534001003 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1001534001004 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1001534001005 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1001534001006 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1001534001007 23S rRNA interface [nucleotide binding]; other site 1001534001008 L21e interface [polypeptide binding]; other site 1001534001009 5S rRNA interface [nucleotide binding]; other site 1001534001010 L27 interface [polypeptide binding]; other site 1001534001011 L5 interface [polypeptide binding]; other site 1001534001012 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1001534001013 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1001534001014 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1001534001015 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1001534001016 23S rRNA binding site [nucleotide binding]; other site 1001534001017 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1001534001018 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1001534001019 SecY translocase; Region: SecY; pfam00344 1001534001020 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 1001534001021 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1001534001022 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1001534001023 30S ribosomal protein S11; Validated; Region: PRK05309 1001534001024 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1001534001025 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1001534001026 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001534001027 RNA binding surface [nucleotide binding]; other site 1001534001028 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1001534001029 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1001534001030 alphaNTD homodimer interface [polypeptide binding]; other site 1001534001031 alphaNTD - beta interaction site [polypeptide binding]; other site 1001534001032 alphaNTD - beta' interaction site [polypeptide binding]; other site 1001534001033 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1001534001034 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1001534001035 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1001534001036 heat shock protein 90; Provisional; Region: PRK05218 1001534001037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001534001038 ATP binding site [chemical binding]; other site 1001534001039 Mg2+ binding site [ion binding]; other site 1001534001040 G-X-G motif; other site 1001534001041 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1001534001042 short chain dehydrogenase; Provisional; Region: PRK05993 1001534001043 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1001534001044 NADP binding site [chemical binding]; other site 1001534001045 active site 1001534001046 steroid binding site; other site 1001534001047 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1001534001048 SnoaL-like domain; Region: SnoaL_2; pfam12680 1001534001049 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1001534001050 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1001534001051 FAD binding pocket [chemical binding]; other site 1001534001052 FAD binding motif [chemical binding]; other site 1001534001053 phosphate binding motif [ion binding]; other site 1001534001054 beta-alpha-beta structure motif; other site 1001534001055 NAD binding pocket [chemical binding]; other site 1001534001056 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1001534001057 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1001534001058 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1001534001059 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1001534001060 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1001534001061 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1001534001062 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1001534001063 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1001534001064 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1001534001065 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1001534001066 active site 1001534001067 multimer interface [polypeptide binding]; other site 1001534001068 CTP synthetase; Validated; Region: pyrG; PRK05380 1001534001069 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1001534001070 Catalytic site [active] 1001534001071 active site 1001534001072 UTP binding site [chemical binding]; other site 1001534001073 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1001534001074 active site 1001534001075 putative oxyanion hole; other site 1001534001076 catalytic triad [active] 1001534001077 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1001534001078 glutamate dehydrogenase; Provisional; Region: PRK09414 1001534001079 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1001534001080 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1001534001081 NAD(P) binding site [chemical binding]; other site 1001534001082 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1001534001083 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 1001534001084 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 1001534001085 active site 1001534001086 (T/H)XGH motif; other site 1001534001087 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1001534001088 nudix motif; other site 1001534001089 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 1001534001090 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1001534001091 Substrate binding site; other site 1001534001092 Mg++ binding site; other site 1001534001093 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1001534001094 active site 1001534001095 substrate binding site [chemical binding]; other site 1001534001096 CoA binding site [chemical binding]; other site 1001534001097 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1001534001098 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1001534001099 glutaminase active site [active] 1001534001100 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1001534001101 dimer interface [polypeptide binding]; other site 1001534001102 active site 1001534001103 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1001534001104 dimer interface [polypeptide binding]; other site 1001534001105 active site 1001534001106 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1001534001107 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1001534001108 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1001534001109 DNA-binding site [nucleotide binding]; DNA binding site 1001534001110 RNA-binding motif; other site 1001534001111 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1001534001112 metal binding site [ion binding]; metal-binding site 1001534001113 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1001534001114 active site 1001534001115 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 1001534001116 PLD-like domain; Region: PLDc_2; pfam13091 1001534001117 putative homodimer interface [polypeptide binding]; other site 1001534001118 putative active site [active] 1001534001119 catalytic site [active] 1001534001120 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1001534001121 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1001534001122 CAP-like domain; other site 1001534001123 active site 1001534001124 primary dimer interface [polypeptide binding]; other site 1001534001125 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1001534001126 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1001534001127 BNR repeat-like domain; Region: BNR_2; pfam13088 1001534001128 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1001534001129 Asp-box motif; other site 1001534001130 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1001534001131 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1001534001132 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1001534001133 catalytic residue [active] 1001534001134 Predicted membrane protein [Function unknown]; Region: COG4325 1001534001135 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1001534001136 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1001534001137 putative active site [active] 1001534001138 putative PHP Thumb interface [polypeptide binding]; other site 1001534001139 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1001534001140 generic binding surface II; other site 1001534001141 generic binding surface I; other site 1001534001142 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1001534001143 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1001534001144 FtsX-like permease family; Region: FtsX; pfam02687 1001534001145 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1001534001146 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1001534001147 Walker A/P-loop; other site 1001534001148 ATP binding site [chemical binding]; other site 1001534001149 Q-loop/lid; other site 1001534001150 ABC transporter signature motif; other site 1001534001151 Walker B; other site 1001534001152 D-loop; other site 1001534001153 H-loop/switch region; other site 1001534001154 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1001534001155 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1001534001156 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1001534001157 homodimer interface [polypeptide binding]; other site 1001534001158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001534001159 catalytic residue [active] 1001534001160 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1001534001161 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1001534001162 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1001534001163 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1001534001164 lipoyl attachment site [posttranslational modification]; other site 1001534001165 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1001534001166 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1001534001167 tetramer interface [polypeptide binding]; other site 1001534001168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001534001169 catalytic residue [active] 1001534001170 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1001534001171 tetramer interface [polypeptide binding]; other site 1001534001172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001534001173 catalytic residue [active] 1001534001174 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1001534001175 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1001534001176 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1001534001177 shikimate binding site; other site 1001534001178 NAD(P) binding site [chemical binding]; other site 1001534001179 pullulanase, type I; Region: pulA_typeI; TIGR02104 1001534001180 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1001534001181 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1001534001182 Ca binding site [ion binding]; other site 1001534001183 active site 1001534001184 catalytic site [active] 1001534001185 glycogen branching enzyme; Provisional; Region: PRK12313 1001534001186 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1001534001187 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1001534001188 active site 1001534001189 catalytic site [active] 1001534001190 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1001534001191 phosphoglucomutase; Region: PLN02307 1001534001192 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 1001534001193 substrate binding site [chemical binding]; other site 1001534001194 dimer interface [polypeptide binding]; other site 1001534001195 active site 1001534001196 metal binding site [ion binding]; metal-binding site 1001534001197 glycogen synthase; Provisional; Region: glgA; PRK00654 1001534001198 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1001534001199 ADP-binding pocket [chemical binding]; other site 1001534001200 homodimer interface [polypeptide binding]; other site 1001534001201 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1001534001202 homodimer interface [polypeptide binding]; other site 1001534001203 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1001534001204 active site pocket [active] 1001534001205 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1001534001206 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1001534001207 dimer interface [polypeptide binding]; other site 1001534001208 motif 1; other site 1001534001209 active site 1001534001210 motif 2; other site 1001534001211 motif 3; other site 1001534001212 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1001534001213 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1001534001214 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001534001215 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001534001216 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1001534001217 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1001534001218 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1001534001219 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001534001220 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1001534001221 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1001534001222 threonine synthase; Validated; Region: PRK09225 1001534001223 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1001534001224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001534001225 catalytic residue [active] 1001534001226 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1001534001227 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 1001534001228 spermidine synthase; Provisional; Region: PRK00811 1001534001229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001534001230 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1001534001231 dimer interface [polypeptide binding]; other site 1001534001232 active site 1001534001233 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1001534001234 catalytic residues [active] 1001534001235 substrate binding site [chemical binding]; other site 1001534001236 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1001534001237 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1001534001238 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1001534001239 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1001534001240 putative active site; other site 1001534001241 catalytic triad [active] 1001534001242 putative dimer interface [polypeptide binding]; other site 1001534001243 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1001534001244 putative active site [active] 1001534001245 putative metal binding site [ion binding]; other site 1001534001246 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001534001247 active site 1001534001248 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1001534001249 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1001534001250 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001534001251 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001534001252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534001253 putative substrate translocation pore; other site 1001534001254 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1001534001255 Predicted membrane protein [Function unknown]; Region: COG4129 1001534001256 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1001534001257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534001258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001534001259 putative substrate translocation pore; other site 1001534001260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534001261 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1001534001262 putative substrate translocation pore; other site 1001534001263 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1001534001264 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1001534001265 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1001534001266 active site 1001534001267 HIGH motif; other site 1001534001268 nucleotide binding site [chemical binding]; other site 1001534001269 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1001534001270 KMSKS motif; other site 1001534001271 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1001534001272 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 1001534001273 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1001534001274 active site 1001534001275 metal-binding site [ion binding] 1001534001276 nucleotide-binding site [chemical binding]; other site 1001534001277 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1001534001278 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1001534001279 Mg++ binding site [ion binding]; other site 1001534001280 putative catalytic motif [active] 1001534001281 putative substrate binding site [chemical binding]; other site 1001534001282 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 1001534001283 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001534001284 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001534001285 cell division protein FtsW; Region: ftsW; TIGR02614 1001534001286 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 1001534001287 putative active site [active] 1001534001288 YdjC motif; other site 1001534001289 Mg binding site [ion binding]; other site 1001534001290 putative homodimer interface [polypeptide binding]; other site 1001534001291 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1001534001292 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1001534001293 Ligand binding site; other site 1001534001294 Putative Catalytic site; other site 1001534001295 DXD motif; other site 1001534001296 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 1001534001297 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1001534001298 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1001534001299 oxidative damage protection protein; Provisional; Region: PRK05408 1001534001300 DsrC like protein; Region: DsrC; pfam04358 1001534001301 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1001534001302 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1001534001303 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1001534001304 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1001534001305 dimer interface [polypeptide binding]; other site 1001534001306 N-terminal domain interface [polypeptide binding]; other site 1001534001307 putative inner membrane peptidase; Provisional; Region: PRK11778 1001534001308 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1001534001309 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1001534001310 tandem repeat interface [polypeptide binding]; other site 1001534001311 oligomer interface [polypeptide binding]; other site 1001534001312 active site residues [active] 1001534001313 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1001534001314 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1001534001315 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1001534001316 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 1001534001317 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1001534001318 dimer interface [polypeptide binding]; other site 1001534001319 active site 1001534001320 Schiff base residues; other site 1001534001321 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1001534001322 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1001534001323 active site 1001534001324 homotetramer interface [polypeptide binding]; other site 1001534001325 homodimer interface [polypeptide binding]; other site 1001534001326 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1001534001327 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1001534001328 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1001534001329 active site 1001534001330 HIGH motif; other site 1001534001331 nucleotide binding site [chemical binding]; other site 1001534001332 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1001534001333 KMSK motif region; other site 1001534001334 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1001534001335 tRNA binding surface [nucleotide binding]; other site 1001534001336 anticodon binding site; other site 1001534001337 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1001534001338 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1001534001339 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1001534001340 SurA N-terminal domain; Region: SurA_N; pfam09312 1001534001341 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1001534001342 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1001534001343 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1001534001344 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1001534001345 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1001534001346 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1001534001347 active site 1001534001348 metal binding site [ion binding]; metal-binding site 1001534001349 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1001534001350 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1001534001351 trimer interface [polypeptide binding]; other site 1001534001352 active site 1001534001353 dimer interface [polypeptide binding]; other site 1001534001354 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1001534001355 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1001534001356 carboxyltransferase (CT) interaction site; other site 1001534001357 biotinylation site [posttranslational modification]; other site 1001534001358 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1001534001359 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1001534001360 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1001534001361 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1001534001362 Helix-turn-helix domain; Region: HTH_25; pfam13413 1001534001363 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1001534001364 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1001534001365 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1001534001366 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 1001534001367 motif 1; other site 1001534001368 dimer interface [polypeptide binding]; other site 1001534001369 active site 1001534001370 motif 2; other site 1001534001371 motif 3; other site 1001534001372 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1001534001373 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1001534001374 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1001534001375 DHH family; Region: DHH; pfam01368 1001534001376 DHHA1 domain; Region: DHHA1; pfam02272 1001534001377 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1001534001378 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1001534001379 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1001534001380 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1001534001381 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1001534001382 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 1001534001383 Predicted GTPases [General function prediction only]; Region: COG1162 1001534001384 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1001534001385 RNA binding site [nucleotide binding]; other site 1001534001386 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1001534001387 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1001534001388 GTP/Mg2+ binding site [chemical binding]; other site 1001534001389 G4 box; other site 1001534001390 G5 box; other site 1001534001391 G1 box; other site 1001534001392 Switch I region; other site 1001534001393 G2 box; other site 1001534001394 G3 box; other site 1001534001395 Switch II region; other site 1001534001396 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 1001534001397 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1001534001398 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1001534001399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001534001400 ATP binding site [chemical binding]; other site 1001534001401 Mg2+ binding site [ion binding]; other site 1001534001402 G-X-G motif; other site 1001534001403 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1001534001404 ATP binding site [chemical binding]; other site 1001534001405 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1001534001406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534001407 putative substrate translocation pore; other site 1001534001408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534001409 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001534001410 putative substrate translocation pore; other site 1001534001411 thioredoxin reductase; Provisional; Region: PRK10262 1001534001412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001534001413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001534001414 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1001534001415 PLD-like domain; Region: PLDc_2; pfam13091 1001534001416 putative active site [active] 1001534001417 catalytic site [active] 1001534001418 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 1001534001419 PLD-like domain; Region: PLDc_2; pfam13091 1001534001420 putative active site [active] 1001534001421 putative catalytic site [active] 1001534001422 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1001534001423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001534001424 motif II; other site 1001534001425 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001534001426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001534001427 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1001534001428 putative effector binding pocket; other site 1001534001429 dimerization interface [polypeptide binding]; other site 1001534001430 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1001534001431 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 1001534001432 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 1001534001433 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1001534001434 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1001534001435 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1001534001436 CoA binding domain; Region: CoA_binding; smart00881 1001534001437 CoA-ligase; Region: Ligase_CoA; pfam00549 1001534001438 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1001534001439 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1001534001440 CoA-ligase; Region: Ligase_CoA; pfam00549 1001534001441 TIGR03546 family protein; Region: TIGR03546 1001534001442 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1001534001443 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1001534001444 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1001534001445 FMN binding site [chemical binding]; other site 1001534001446 active site 1001534001447 catalytic residues [active] 1001534001448 substrate binding site [chemical binding]; other site 1001534001449 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1001534001450 putative active site pocket [active] 1001534001451 dimerization interface [polypeptide binding]; other site 1001534001452 putative catalytic residue [active] 1001534001453 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1001534001454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001534001455 ATP binding site [chemical binding]; other site 1001534001456 Mg2+ binding site [ion binding]; other site 1001534001457 G-X-G motif; other site 1001534001458 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1001534001459 anchoring element; other site 1001534001460 dimer interface [polypeptide binding]; other site 1001534001461 ATP binding site [chemical binding]; other site 1001534001462 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1001534001463 active site 1001534001464 putative metal-binding site [ion binding]; other site 1001534001465 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1001534001466 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1001534001467 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1001534001468 active site 1001534001469 multimer interface [polypeptide binding]; other site 1001534001470 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1001534001471 predicted active site [active] 1001534001472 catalytic triad [active] 1001534001473 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1001534001474 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1001534001475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001534001476 S-adenosylmethionine binding site [chemical binding]; other site 1001534001477 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1001534001478 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1001534001479 FMN binding site [chemical binding]; other site 1001534001480 active site 1001534001481 catalytic residues [active] 1001534001482 substrate binding site [chemical binding]; other site 1001534001483 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1001534001484 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1001534001485 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1001534001486 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1001534001487 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1001534001488 putative active site [active] 1001534001489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001534001490 AAA domain; Region: AAA_21; pfam13304 1001534001491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001534001492 Walker A/P-loop; other site 1001534001493 Walker A/P-loop; other site 1001534001494 ATP binding site [chemical binding]; other site 1001534001495 ATP binding site [chemical binding]; other site 1001534001496 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1001534001497 DJ-1 family protein; Region: not_thiJ; TIGR01383 1001534001498 conserved cys residue [active] 1001534001499 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 1001534001500 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1001534001501 GSH binding site [chemical binding]; other site 1001534001502 catalytic residues [active] 1001534001503 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1001534001504 dimer interface [polypeptide binding]; other site 1001534001505 putative radical transfer pathway; other site 1001534001506 diiron center [ion binding]; other site 1001534001507 tyrosyl radical; other site 1001534001508 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1001534001509 GSH binding site [chemical binding]; other site 1001534001510 catalytic residues [active] 1001534001511 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 1001534001512 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1001534001513 active site 1001534001514 dimer interface [polypeptide binding]; other site 1001534001515 catalytic residues [active] 1001534001516 effector binding site; other site 1001534001517 R2 peptide binding site; other site 1001534001518 malate dehydrogenase; Reviewed; Region: PRK06223 1001534001519 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1001534001520 NAD(P) binding site [chemical binding]; other site 1001534001521 dimer interface [polypeptide binding]; other site 1001534001522 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1001534001523 substrate binding site [chemical binding]; other site 1001534001524 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1001534001525 diiron binding motif [ion binding]; other site 1001534001526 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1001534001527 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1001534001528 catalytic residue [active] 1001534001529 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1001534001530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001534001531 motif II; other site 1001534001532 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1001534001533 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1001534001534 PhnA protein; Region: PhnA; pfam03831 1001534001535 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1001534001536 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1001534001537 active site 1001534001538 catalytic site [active] 1001534001539 substrate binding site [chemical binding]; other site 1001534001540 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1001534001541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 1001534001542 aldehyde dehydrogenase family 7 member; Region: PLN02315 1001534001543 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1001534001544 tetrameric interface [polypeptide binding]; other site 1001534001545 NAD binding site [chemical binding]; other site 1001534001546 catalytic residues [active] 1001534001547 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1001534001548 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1001534001549 putative homodimer interface [polypeptide binding]; other site 1001534001550 putative homotetramer interface [polypeptide binding]; other site 1001534001551 putative allosteric switch controlling residues; other site 1001534001552 putative metal binding site [ion binding]; other site 1001534001553 putative homodimer-homodimer interface [polypeptide binding]; other site 1001534001554 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1001534001555 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1001534001556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001534001557 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1001534001558 dimerization interface [polypeptide binding]; other site 1001534001559 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1001534001560 catalytic triad [active] 1001534001561 dimer interface [polypeptide binding]; other site 1001534001562 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1001534001563 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1001534001564 putative NAD(P) binding site [chemical binding]; other site 1001534001565 homodimer interface [polypeptide binding]; other site 1001534001566 cytidylate kinase; Provisional; Region: cmk; PRK00023 1001534001567 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1001534001568 CMP-binding site; other site 1001534001569 The sites determining sugar specificity; other site 1001534001570 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1001534001571 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001534001572 catalytic residue [active] 1001534001573 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1001534001574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001534001575 Walker A/P-loop; other site 1001534001576 ATP binding site [chemical binding]; other site 1001534001577 Q-loop/lid; other site 1001534001578 ABC transporter signature motif; other site 1001534001579 Walker B; other site 1001534001580 D-loop; other site 1001534001581 H-loop/switch region; other site 1001534001582 TOBE domain; Region: TOBE_2; pfam08402 1001534001583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001534001584 dimer interface [polypeptide binding]; other site 1001534001585 conserved gate region; other site 1001534001586 putative PBP binding loops; other site 1001534001587 ABC-ATPase subunit interface; other site 1001534001588 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1001534001589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001534001590 dimer interface [polypeptide binding]; other site 1001534001591 conserved gate region; other site 1001534001592 putative PBP binding loops; other site 1001534001593 ABC-ATPase subunit interface; other site 1001534001594 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1001534001595 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001534001596 motif II; other site 1001534001597 hypothetical protein; Provisional; Region: PRK14013 1001534001598 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1001534001599 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 1001534001600 putative C-terminal domain interface [polypeptide binding]; other site 1001534001601 putative GSH binding site [chemical binding]; other site 1001534001602 putative dimer interface [polypeptide binding]; other site 1001534001603 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1001534001604 dimer interface [polypeptide binding]; other site 1001534001605 substrate binding pocket (H-site) [chemical binding]; other site 1001534001606 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 1001534001607 putative N-terminal domain interface [polypeptide binding]; other site 1001534001608 POT family; Region: PTR2; cl17359 1001534001609 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1001534001610 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1001534001611 active site 1001534001612 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1001534001613 dimer interface [polypeptide binding]; other site 1001534001614 substrate binding site [chemical binding]; other site 1001534001615 catalytic residues [active] 1001534001616 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1001534001617 Prephenate dehydratase; Region: PDT; pfam00800 1001534001618 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1001534001619 putative L-Phe binding site [chemical binding]; other site 1001534001620 Protein of unknown function DUF45; Region: DUF45; pfam01863 1001534001621 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1001534001622 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1001534001623 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1001534001624 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1001534001625 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1001534001626 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001534001627 catalytic residue [active] 1001534001628 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1001534001629 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 1001534001630 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1001534001631 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1001534001632 active site 1001534001633 (T/H)XGH motif; other site 1001534001634 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1001534001635 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1001534001636 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1001534001637 ligand binding site [chemical binding]; other site 1001534001638 CRISPR/Cas system-associated protein Cas9; Region: Csx12; cd09704 1001534001639 CRISPR-associated protein Cas9/Csx12, subtype II-B/NMENI; Region: cas_csx12; TIGR03031 1001534001640 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1001534001641 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1001534001642 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1001534001643 hinge; other site 1001534001644 active site 1001534001645 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1001534001646 RNA/DNA hybrid binding site [nucleotide binding]; other site 1001534001647 active site 1001534001648 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1001534001649 active site 1001534001650 homodimer interface [polypeptide binding]; other site 1001534001651 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1001534001652 active site clefts [active] 1001534001653 zinc binding site [ion binding]; other site 1001534001654 dimer interface [polypeptide binding]; other site 1001534001655 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1001534001656 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1001534001657 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001534001658 catalytic residue [active] 1001534001659 Rubredoxin [Energy production and conversion]; Region: COG1773 1001534001660 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1001534001661 iron binding site [ion binding]; other site 1001534001662 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1001534001663 hypothetical protein; Validated; Region: PRK00029 1001534001664 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1001534001665 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1001534001666 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1001534001667 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1001534001668 dimer interface [polypeptide binding]; other site 1001534001669 active site 1001534001670 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1001534001671 dimer interface [polypeptide binding]; other site 1001534001672 active site 1001534001673 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 1001534001674 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 1001534001675 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1001534001676 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1001534001677 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1001534001678 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1001534001679 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1001534001680 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1001534001681 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1001534001682 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1001534001683 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1001534001684 active site 1001534001685 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1001534001686 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1001534001687 active site 1001534001688 substrate binding site [chemical binding]; other site 1001534001689 Mg2+ binding site [ion binding]; other site 1001534001690 beta-lactamase TEM; Provisional; Region: PRK15442 1001534001691 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1001534001692 VirK protein; Region: VirK; pfam06903 1001534001693 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1001534001694 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1001534001695 putative active site [active] 1001534001696 catalytic triad [active] 1001534001697 putative dimer interface [polypeptide binding]; other site 1001534001698 FOG: CBS domain [General function prediction only]; Region: COG0517 1001534001699 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1001534001700 Transporter associated domain; Region: CorC_HlyC; smart01091 1001534001701 metal-binding heat shock protein; Provisional; Region: PRK00016 1001534001702 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1001534001703 PhoH-like protein; Region: PhoH; pfam02562 1001534001704 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1001534001705 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1001534001706 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001534001707 FeS/SAM binding site; other site 1001534001708 TRAM domain; Region: TRAM; pfam01938 1001534001709 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1001534001710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1001534001711 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 1001534001712 thymidine kinase; Provisional; Region: PRK04296 1001534001713 trigger factor; Provisional; Region: tig; PRK01490 1001534001714 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1001534001715 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1001534001716 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1001534001717 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1001534001718 oligomer interface [polypeptide binding]; other site 1001534001719 active site residues [active] 1001534001720 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1001534001721 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1001534001722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001534001723 Walker A motif; other site 1001534001724 ATP binding site [chemical binding]; other site 1001534001725 Walker B motif; other site 1001534001726 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1001534001727 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1001534001728 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1001534001729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001534001730 Walker A motif; other site 1001534001731 ATP binding site [chemical binding]; other site 1001534001732 Walker B motif; other site 1001534001733 arginine finger; other site 1001534001734 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1001534001735 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1001534001736 IHF dimer interface [polypeptide binding]; other site 1001534001737 IHF - DNA interface [nucleotide binding]; other site 1001534001738 SurA N-terminal domain; Region: SurA_N_3; cl07813 1001534001739 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1001534001740 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1001534001741 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1001534001742 bacterial Hfq-like; Region: Hfq; cd01716 1001534001743 hexamer interface [polypeptide binding]; other site 1001534001744 Sm1 motif; other site 1001534001745 RNA binding site [nucleotide binding]; other site 1001534001746 Sm2 motif; other site 1001534001747 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1001534001748 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1001534001749 HflX GTPase family; Region: HflX; cd01878 1001534001750 G1 box; other site 1001534001751 GTP/Mg2+ binding site [chemical binding]; other site 1001534001752 Switch I region; other site 1001534001753 G2 box; other site 1001534001754 G3 box; other site 1001534001755 Switch II region; other site 1001534001756 G4 box; other site 1001534001757 G5 box; other site 1001534001758 hypothetical protein; Provisional; Region: PRK07588 1001534001759 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1001534001760 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1001534001761 HflK protein; Region: hflK; TIGR01933 1001534001762 FtsH protease regulator HflC; Provisional; Region: PRK11029 1001534001763 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1001534001764 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1001534001765 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1001534001766 active site 1001534001767 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1001534001768 G1 box; other site 1001534001769 GTP/Mg2+ binding site [chemical binding]; other site 1001534001770 Switch I region; other site 1001534001771 G2 box; other site 1001534001772 G3 box; other site 1001534001773 Switch II region; other site 1001534001774 G4 box; other site 1001534001775 G5 box; other site 1001534001776 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1001534001777 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1001534001778 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1001534001779 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1001534001780 putative valine binding site [chemical binding]; other site 1001534001781 dimer interface [polypeptide binding]; other site 1001534001782 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1001534001783 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1001534001784 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001534001785 ATP binding site [chemical binding]; other site 1001534001786 putative Mg++ binding site [ion binding]; other site 1001534001787 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001534001788 nucleotide binding region [chemical binding]; other site 1001534001789 ATP-binding site [chemical binding]; other site 1001534001790 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1001534001791 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1001534001792 YccA-like proteins; Region: YccA_like; cd10433 1001534001793 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 1001534001794 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1001534001795 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1001534001796 minor groove reading motif; other site 1001534001797 helix-hairpin-helix signature motif; other site 1001534001798 substrate binding pocket [chemical binding]; other site 1001534001799 active site 1001534001800 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1001534001801 ferredoxin; Provisional; Region: PRK08764 1001534001802 Putative Fe-S cluster; Region: FeS; cl17515 1001534001803 4Fe-4S binding domain; Region: Fer4; pfam00037 1001534001804 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1001534001805 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1001534001806 N-terminal domain interface [polypeptide binding]; other site 1001534001807 POT family; Region: PTR2; cl17359 1001534001808 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1001534001809 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1001534001810 Ferritin-like domain; Region: Ferritin; pfam00210 1001534001811 ferroxidase diiron center [ion binding]; other site 1001534001812 lipoyl synthase; Provisional; Region: PRK05481 1001534001813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001534001814 FeS/SAM binding site; other site 1001534001815 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1001534001816 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1001534001817 conserved cys residue [active] 1001534001818 hypothetical protein; Validated; Region: PRK00110 1001534001819 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1001534001820 active site 1001534001821 putative DNA-binding cleft [nucleotide binding]; other site 1001534001822 dimer interface [polypeptide binding]; other site 1001534001823 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1001534001824 RuvA N terminal domain; Region: RuvA_N; pfam01330 1001534001825 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1001534001826 RmuC family; Region: RmuC; pfam02646 1001534001827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 1001534001828 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1001534001829 histidine decarboxylase; Provisional; Region: PRK02769 1001534001830 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001534001831 catalytic residue [active] 1001534001832 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1001534001833 intersubunit interface [polypeptide binding]; other site 1001534001834 active site 1001534001835 Zn2+ binding site [ion binding]; other site 1001534001836 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1001534001837 active site 1001534001838 DNA binding site [nucleotide binding] 1001534001839 Isochorismatase family; Region: Isochorismatase; pfam00857 1001534001840 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1001534001841 catalytic triad [active] 1001534001842 conserved cis-peptide bond; other site 1001534001843 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1001534001844 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1001534001845 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1001534001846 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1001534001847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534001848 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001534001849 putative substrate translocation pore; other site 1001534001850 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 1001534001851 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1001534001852 putative active site [active] 1001534001853 Zn binding site [ion binding]; other site 1001534001854 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1001534001855 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1001534001856 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001534001857 active site 1001534001858 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1001534001859 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1001534001860 5S rRNA interface [nucleotide binding]; other site 1001534001861 CTC domain interface [polypeptide binding]; other site 1001534001862 L16 interface [polypeptide binding]; other site 1001534001863 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1001534001864 Domain of unknown function DUF21; Region: DUF21; pfam01595 1001534001865 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1001534001866 Transporter associated domain; Region: CorC_HlyC; pfam03471 1001534001867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1001534001868 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1001534001869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001534001870 S-adenosylmethionine binding site [chemical binding]; other site 1001534001871 GTP-binding protein YchF; Reviewed; Region: PRK09601 1001534001872 YchF GTPase; Region: YchF; cd01900 1001534001873 G1 box; other site 1001534001874 GTP/Mg2+ binding site [chemical binding]; other site 1001534001875 Switch I region; other site 1001534001876 G2 box; other site 1001534001877 Switch II region; other site 1001534001878 G3 box; other site 1001534001879 G4 box; other site 1001534001880 G5 box; other site 1001534001881 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1001534001882 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1001534001883 putative active site [active] 1001534001884 catalytic residue [active] 1001534001885 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1001534001886 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1001534001887 dimerization domain [polypeptide binding]; other site 1001534001888 dimer interface [polypeptide binding]; other site 1001534001889 catalytic residues [active] 1001534001890 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1001534001891 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1001534001892 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1001534001893 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1001534001894 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001534001895 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1001534001896 voltage-gated potassium channel; Provisional; Region: PRK10537 1001534001897 Ion channel; Region: Ion_trans_2; pfam07885 1001534001898 POT family; Region: PTR2; cl17359 1001534001899 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1001534001900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001534001901 Walker A motif; other site 1001534001902 ATP binding site [chemical binding]; other site 1001534001903 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1001534001904 Walker B motif; other site 1001534001905 arginine finger; other site 1001534001906 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1001534001907 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1001534001908 active site 1001534001909 HslU subunit interaction site [polypeptide binding]; other site 1001534001910 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1001534001911 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1001534001912 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1001534001913 active site 1001534001914 HIGH motif; other site 1001534001915 dimer interface [polypeptide binding]; other site 1001534001916 KMSKS motif; other site 1001534001917 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001534001918 RNA binding surface [nucleotide binding]; other site 1001534001919 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1001534001920 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1001534001921 DNA binding site [nucleotide binding] 1001534001922 catalytic residue [active] 1001534001923 H2TH interface [polypeptide binding]; other site 1001534001924 putative catalytic residues [active] 1001534001925 turnover-facilitating residue; other site 1001534001926 intercalation triad [nucleotide binding]; other site 1001534001927 8OG recognition residue [nucleotide binding]; other site 1001534001928 putative reading head residues; other site 1001534001929 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1001534001930 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1001534001931 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1001534001932 AMP-binding enzyme; Region: AMP-binding; pfam00501 1001534001933 acyl-activating enzyme (AAE) consensus motif; other site 1001534001934 putative AMP binding site [chemical binding]; other site 1001534001935 MraW methylase family; Region: Methyltransf_5; cl17771 1001534001936 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1001534001937 Cell division protein FtsL; Region: FtsL; cl11433 1001534001938 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1001534001939 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1001534001940 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1001534001941 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1001534001942 16S/18S rRNA binding site [nucleotide binding]; other site 1001534001943 S13e-L30e interaction site [polypeptide binding]; other site 1001534001944 25S rRNA binding site [nucleotide binding]; other site 1001534001945 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1001534001946 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1001534001947 oligomer interface [polypeptide binding]; other site 1001534001948 RNA binding site [nucleotide binding]; other site 1001534001949 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1001534001950 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1001534001951 RNase E interface [polypeptide binding]; other site 1001534001952 trimer interface [polypeptide binding]; other site 1001534001953 active site 1001534001954 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1001534001955 putative nucleic acid binding region [nucleotide binding]; other site 1001534001956 G-X-X-G motif; other site 1001534001957 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1001534001958 RNA binding site [nucleotide binding]; other site 1001534001959 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1001534001960 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1001534001961 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1001534001962 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1001534001963 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1001534001964 ATP-binding site [chemical binding]; other site 1001534001965 Sugar specificity; other site 1001534001966 Pyrimidine base specificity; other site 1001534001967 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1001534001968 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1001534001969 TRAM domain; Region: TRAM; pfam01938 1001534001970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001534001971 S-adenosylmethionine binding site [chemical binding]; other site 1001534001972 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1001534001973 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001534001974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534001975 putative substrate translocation pore; other site 1001534001976 enolase; Provisional; Region: eno; PRK00077 1001534001977 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1001534001978 dimer interface [polypeptide binding]; other site 1001534001979 metal binding site [ion binding]; metal-binding site 1001534001980 substrate binding pocket [chemical binding]; other site 1001534001981 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1001534001982 Septum formation initiator; Region: DivIC; cl17659 1001534001983 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1001534001984 substrate binding site; other site 1001534001985 dimer interface; other site 1001534001986 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1001534001987 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1001534001988 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1001534001989 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1001534001990 NAD(P) binding site [chemical binding]; other site 1001534001991 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1001534001992 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1001534001993 substrate-cofactor binding pocket; other site 1001534001994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001534001995 catalytic residue [active] 1001534001996 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1001534001997 Glyco_18 domain; Region: Glyco_18; smart00636 1001534001998 active site 1001534001999 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1001534002000 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1001534002001 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1001534002002 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1001534002003 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1001534002004 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001534002005 active site 1001534002006 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1001534002007 putative substrate binding pocket [chemical binding]; other site 1001534002008 trimer interface [polypeptide binding]; other site 1001534002009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534002010 metabolite-proton symporter; Region: 2A0106; TIGR00883 1001534002011 putative substrate translocation pore; other site 1001534002012 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 1001534002013 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001534002014 Zn2+ binding site [ion binding]; other site 1001534002015 Mg2+ binding site [ion binding]; other site 1001534002016 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1001534002017 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1001534002018 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1001534002019 heme binding site [chemical binding]; other site 1001534002020 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1001534002021 classical (c) SDRs; Region: SDR_c; cd05233 1001534002022 NAD(P) binding site [chemical binding]; other site 1001534002023 active site 1001534002024 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1001534002025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534002026 putative substrate translocation pore; other site 1001534002027 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1001534002028 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1001534002029 active site 1001534002030 catalytic site [active] 1001534002031 metal binding site [ion binding]; metal-binding site 1001534002032 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1001534002033 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1001534002034 Walker A/P-loop; other site 1001534002035 ATP binding site [chemical binding]; other site 1001534002036 Q-loop/lid; other site 1001534002037 ABC transporter signature motif; other site 1001534002038 Walker B; other site 1001534002039 D-loop; other site 1001534002040 H-loop/switch region; other site 1001534002041 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1001534002042 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1001534002043 Chorismate mutase type II; Region: CM_2; smart00830 1001534002044 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1001534002045 catalytic residues [active] 1001534002046 dimer interface [polypeptide binding]; other site 1001534002047 Putative serine esterase (DUF676); Region: DUF676; pfam05057 1001534002048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1001534002049 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1001534002050 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1001534002051 putative substrate binding site [chemical binding]; other site 1001534002052 putative ATP binding site [chemical binding]; other site 1001534002053 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001534002054 RNA binding surface [nucleotide binding]; other site 1001534002055 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1001534002056 OstA-like protein; Region: OstA; cl00844 1001534002057 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1001534002058 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1001534002059 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1001534002060 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1001534002061 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1001534002062 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1001534002063 HlyD family secretion protein; Region: HlyD_3; pfam13437 1001534002064 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 1001534002065 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1001534002066 non-specific DNA interactions [nucleotide binding]; other site 1001534002067 DNA binding site [nucleotide binding] 1001534002068 sequence specific DNA binding site [nucleotide binding]; other site 1001534002069 putative cAMP binding site [chemical binding]; other site 1001534002070 Bacterial transcriptional regulator; Region: IclR; pfam01614 1001534002071 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1001534002072 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1001534002073 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1001534002074 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1001534002075 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001534002076 FeS/SAM binding site; other site 1001534002077 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1001534002078 DNA-binding site [nucleotide binding]; DNA binding site 1001534002079 RNA-binding motif; other site 1001534002080 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1001534002081 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1001534002082 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1001534002083 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1001534002084 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1001534002085 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1001534002086 active site 1001534002087 tetramer interface; other site 1001534002088 EamA-like transporter family; Region: EamA; pfam00892 1001534002089 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1001534002090 EamA-like transporter family; Region: EamA; pfam00892 1001534002091 recombination protein F; Reviewed; Region: recF; PRK00064 1001534002092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001534002093 Walker A/P-loop; other site 1001534002094 ATP binding site [chemical binding]; other site 1001534002095 Q-loop/lid; other site 1001534002096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001534002097 ABC transporter signature motif; other site 1001534002098 Walker B; other site 1001534002099 D-loop; other site 1001534002100 H-loop/switch region; other site 1001534002101 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1001534002102 active site 1001534002103 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1001534002104 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1001534002105 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1001534002106 LPP20 lipoprotein; Region: LPP20; cl15824 1001534002107 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1001534002108 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1001534002109 ATP binding site [chemical binding]; other site 1001534002110 putative Mg++ binding site [ion binding]; other site 1001534002111 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1001534002112 SEC-C motif; Region: SEC-C; pfam02810 1001534002113 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1001534002114 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1001534002115 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1001534002116 ribonuclease D; Region: rnd; TIGR01388 1001534002117 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1001534002118 catalytic site [active] 1001534002119 putative active site [active] 1001534002120 putative substrate binding site [chemical binding]; other site 1001534002121 HRDC domain; Region: HRDC; pfam00570 1001534002122 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1001534002123 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1001534002124 active site 1001534002125 catalytic site [active] 1001534002126 putative DNA binding site [nucleotide binding]; other site 1001534002127 GIY-YIG motif/motif A; other site 1001534002128 metal binding site [ion binding]; metal-binding site 1001534002129 UvrB/uvrC motif; Region: UVR; pfam02151 1001534002130 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1001534002131 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1001534002132 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1001534002133 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1001534002134 NAD binding site [chemical binding]; other site 1001534002135 homotetramer interface [polypeptide binding]; other site 1001534002136 homodimer interface [polypeptide binding]; other site 1001534002137 substrate binding site [chemical binding]; other site 1001534002138 active site 1001534002139 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1001534002140 hypothetical protein; Provisional; Region: PRK05409 1001534002141 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 1001534002142 Predicted membrane protein [Function unknown]; Region: COG2259 1001534002143 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1001534002144 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1001534002145 putative active site [active] 1001534002146 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1001534002147 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1001534002148 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1001534002149 substrate binding site [chemical binding]; other site 1001534002150 hexamer interface [polypeptide binding]; other site 1001534002151 metal binding site [ion binding]; metal-binding site 1001534002152 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1001534002153 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1001534002154 UDP-glucose 4-epimerase; Region: PLN02240 1001534002155 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1001534002156 NAD binding site [chemical binding]; other site 1001534002157 homodimer interface [polypeptide binding]; other site 1001534002158 active site 1001534002159 substrate binding site [chemical binding]; other site 1001534002160 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001534002161 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1001534002162 putative ADP-binding pocket [chemical binding]; other site 1001534002163 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1001534002164 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001534002165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001534002166 Walker A/P-loop; other site 1001534002167 ATP binding site [chemical binding]; other site 1001534002168 Q-loop/lid; other site 1001534002169 ABC transporter signature motif; other site 1001534002170 Walker B; other site 1001534002171 D-loop; other site 1001534002172 H-loop/switch region; other site 1001534002173 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1001534002174 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1001534002175 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1001534002176 active site 1001534002177 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1001534002178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001534002179 S-adenosylmethionine binding site [chemical binding]; other site 1001534002180 LicD family; Region: LicD; pfam04991 1001534002181 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1001534002182 active site 1001534002183 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1001534002184 active site 1001534002185 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1001534002186 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001534002187 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 1001534002188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001534002189 motif II; other site 1001534002190 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1001534002191 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1001534002192 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1001534002193 substrate binding site [chemical binding]; other site 1001534002194 ATP binding site [chemical binding]; other site 1001534002195 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1001534002196 proposed catalytic triad [active] 1001534002197 active site nucleophile [active] 1001534002198 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1001534002199 catalytic nucleophile [active] 1001534002200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534002201 metabolite-proton symporter; Region: 2A0106; TIGR00883 1001534002202 putative substrate translocation pore; other site 1001534002203 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1001534002204 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001534002205 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1001534002206 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 1001534002207 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1001534002208 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001534002209 Zn2+ binding site [ion binding]; other site 1001534002210 Mg2+ binding site [ion binding]; other site 1001534002211 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1001534002212 synthetase active site [active] 1001534002213 NTP binding site [chemical binding]; other site 1001534002214 metal binding site [ion binding]; metal-binding site 1001534002215 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1001534002216 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1001534002217 recombination protein RecR; Provisional; Region: PRK13844 1001534002218 RecR protein; Region: RecR; pfam02132 1001534002219 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1001534002220 putative active site [active] 1001534002221 putative metal-binding site [ion binding]; other site 1001534002222 tetramer interface [polypeptide binding]; other site 1001534002223 hypothetical protein; Validated; Region: PRK00153 1001534002224 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1001534002225 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1001534002226 homodimer interface [polypeptide binding]; other site 1001534002227 active site 1001534002228 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1001534002229 lipoyl attachment site [posttranslational modification]; other site 1001534002230 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1001534002231 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1001534002232 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1001534002233 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1001534002234 active site 1001534002235 dimer interface [polypeptide binding]; other site 1001534002236 motif 1; other site 1001534002237 motif 2; other site 1001534002238 motif 3; other site 1001534002239 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1001534002240 anticodon binding site; other site 1001534002241 translation initiation factor IF-3; Region: infC; TIGR00168 1001534002242 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1001534002243 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1001534002244 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1001534002245 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1001534002246 23S rRNA binding site [nucleotide binding]; other site 1001534002247 L21 binding site [polypeptide binding]; other site 1001534002248 L13 binding site [polypeptide binding]; other site 1001534002249 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1001534002250 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1001534002251 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1001534002252 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1001534002253 nudix motif; other site 1001534002254 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 1001534002255 ArsC family; Region: ArsC; pfam03960 1001534002256 catalytic residue [active] 1001534002257 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1001534002258 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 1001534002259 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1001534002260 TrkA-C domain; Region: TrkA_C; pfam02080 1001534002261 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1001534002262 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1001534002263 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1001534002264 ligand binding site [chemical binding]; other site 1001534002265 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1001534002266 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1001534002267 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1001534002268 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1001534002269 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1001534002270 homotrimer interaction site [polypeptide binding]; other site 1001534002271 active site 1001534002272 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1001534002273 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1001534002274 TolQ protein; Region: tolQ; TIGR02796 1001534002275 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1001534002276 TolR protein; Region: tolR; TIGR02801 1001534002277 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1001534002278 TolB amino-terminal domain; Region: TolB_N; pfam04052 1001534002279 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1001534002280 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1001534002281 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1001534002282 ligand binding site [chemical binding]; other site 1001534002283 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 1001534002284 DNA photolyase; Region: DNA_photolyase; pfam00875 1001534002285 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1001534002286 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 1001534002287 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 1001534002288 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 1001534002289 bile acid transporter; Region: bass; TIGR00841 1001534002290 Sodium Bile acid symporter family; Region: SBF; cl17470 1001534002291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1001534002292 YheO-like PAS domain; Region: PAS_6; pfam08348 1001534002293 HTH domain; Region: HTH_22; pfam13309 1001534002294 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1001534002295 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1001534002296 transmembrane helices; other site 1001534002297 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1001534002298 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1001534002299 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 1001534002300 UbiA prenyltransferase family; Region: UbiA; pfam01040 1001534002301 Chorismate lyase; Region: Chor_lyase; cl01230 1001534002302 ribonuclease PH; Reviewed; Region: rph; PRK00173 1001534002303 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1001534002304 hexamer interface [polypeptide binding]; other site 1001534002305 active site 1001534002306 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1001534002307 heat shock protein HtpX; Provisional; Region: PRK02870 1001534002308 LemA family; Region: LemA; cl00742 1001534002309 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1001534002310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001534002311 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1001534002312 putative dimerization interface [polypeptide binding]; other site 1001534002313 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1001534002314 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1001534002315 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001534002316 dimerization interface [polypeptide binding]; other site 1001534002317 putative DNA binding site [nucleotide binding]; other site 1001534002318 putative Zn2+ binding site [ion binding]; other site 1001534002319 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1001534002320 putative active site [active] 1001534002321 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1001534002322 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1001534002323 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1001534002324 Colicin V production protein; Region: Colicin_V; pfam02674 1001534002325 DNA repair protein RadA; Provisional; Region: PRK11823 1001534002326 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1001534002327 Walker A motif/ATP binding site; other site 1001534002328 ATP binding site [chemical binding]; other site 1001534002329 Walker B motif; other site 1001534002330 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1001534002331 PilZ domain; Region: PilZ; pfam07238 1001534002332 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1001534002333 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1001534002334 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1001534002335 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1001534002336 Tetramer interface [polypeptide binding]; other site 1001534002337 active site 1001534002338 FMN-binding site [chemical binding]; other site 1001534002339 PQ loop repeat; Region: PQ-loop; pfam04193 1001534002340 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1001534002341 SelR domain; Region: SelR; pfam01641 1001534002342 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1001534002343 E-class dimer interface [polypeptide binding]; other site 1001534002344 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1001534002345 P-class dimer interface [polypeptide binding]; other site 1001534002346 active site 1001534002347 Cu2+ binding site [ion binding]; other site 1001534002348 Zn2+ binding site [ion binding]; other site 1001534002349 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1001534002350 aspartate aminotransferase; Provisional; Region: PRK07568 1001534002351 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001534002352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001534002353 homodimer interface [polypeptide binding]; other site 1001534002354 catalytic residue [active] 1001534002355 Cation efflux family; Region: Cation_efflux; pfam01545 1001534002356 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1001534002357 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1001534002358 Walker A/P-loop; other site 1001534002359 ATP binding site [chemical binding]; other site 1001534002360 Q-loop/lid; other site 1001534002361 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1001534002362 ABC transporter signature motif; other site 1001534002363 Walker B; other site 1001534002364 D-loop; other site 1001534002365 H-loop/switch region; other site 1001534002366 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 1001534002367 Pilin (bacterial filament); Region: Pilin; pfam00114 1001534002368 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 1001534002369 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 1001534002370 Pilin (bacterial filament); Region: Pilin; pfam00114 1001534002371 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 1001534002372 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1001534002373 active site 1001534002374 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 1001534002375 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1001534002376 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1001534002377 homodimer interface [polypeptide binding]; other site 1001534002378 NADP binding site [chemical binding]; other site 1001534002379 substrate binding site [chemical binding]; other site 1001534002380 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1001534002381 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1001534002382 dimerization interface [polypeptide binding]; other site 1001534002383 putative ATP binding site [chemical binding]; other site 1001534002384 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1001534002385 active site 1001534002386 ATP binding site [chemical binding]; other site 1001534002387 substrate binding site [chemical binding]; other site 1001534002388 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1001534002389 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1001534002390 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1001534002391 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1001534002392 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1001534002393 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1001534002394 active site 1001534002395 substrate binding site [chemical binding]; other site 1001534002396 cosubstrate binding site; other site 1001534002397 catalytic site [active] 1001534002398 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1001534002399 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1001534002400 ATP-grasp domain; Region: ATP-grasp; pfam02222 1001534002401 hypothetical protein; Provisional; Region: PRK14682 1001534002402 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1001534002403 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1001534002404 active site 1001534002405 Zn binding site [ion binding]; other site 1001534002406 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 1001534002407 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1001534002408 DNA topoisomerase I; Validated; Region: PRK06599 1001534002409 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1001534002410 active site 1001534002411 interdomain interaction site; other site 1001534002412 putative metal-binding site [ion binding]; other site 1001534002413 nucleotide binding site [chemical binding]; other site 1001534002414 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1001534002415 domain I; other site 1001534002416 DNA binding groove [nucleotide binding] 1001534002417 phosphate binding site [ion binding]; other site 1001534002418 domain II; other site 1001534002419 domain III; other site 1001534002420 nucleotide binding site [chemical binding]; other site 1001534002421 catalytic site [active] 1001534002422 domain IV; other site 1001534002423 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1001534002424 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1001534002425 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1001534002426 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1001534002427 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1001534002428 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1001534002429 P-loop; other site 1001534002430 Magnesium ion binding site [ion binding]; other site 1001534002431 ParB-like nuclease domain; Region: ParB; smart00470 1001534002432 KorB domain; Region: KorB; pfam08535 1001534002433 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1001534002434 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1001534002435 catalytic triad [active] 1001534002436 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1001534002437 active site 1001534002438 catalytic triad [active] 1001534002439 oxyanion hole [active] 1001534002440 HD domain; Region: HD_3; pfam13023 1001534002441 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1001534002442 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1001534002443 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1001534002444 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1001534002445 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1001534002446 active site 1001534002447 HIGH motif; other site 1001534002448 nucleotide binding site [chemical binding]; other site 1001534002449 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1001534002450 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1001534002451 active site 1001534002452 KMSKS motif; other site 1001534002453 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1001534002454 tRNA binding surface [nucleotide binding]; other site 1001534002455 anticodon binding site; other site 1001534002456 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1001534002457 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1001534002458 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1001534002459 active site 1001534002460 Riboflavin kinase; Region: Flavokinase; pfam01687 1001534002461 malate dehydrogenase; Provisional; Region: PRK13529 1001534002462 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1001534002463 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1001534002464 NAD(P) binding pocket [chemical binding]; other site 1001534002465 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 1001534002466 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 1001534002467 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1001534002468 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1001534002469 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1001534002470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1001534002471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001534002472 S-adenosylmethionine binding site [chemical binding]; other site 1001534002473 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1001534002474 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1001534002475 putative active site [active] 1001534002476 substrate binding site [chemical binding]; other site 1001534002477 putative cosubstrate binding site; other site 1001534002478 catalytic site [active] 1001534002479 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1001534002480 substrate binding site [chemical binding]; other site 1001534002481 glutathione synthetase; Provisional; Region: PRK05246 1001534002482 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1001534002483 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1001534002484 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1001534002485 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1001534002486 inhibitor-cofactor binding pocket; inhibition site 1001534002487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001534002488 catalytic residue [active] 1001534002489 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1001534002490 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1001534002491 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1001534002492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534002493 putative substrate translocation pore; other site 1001534002494 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1001534002495 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1001534002496 nucleotide binding site [chemical binding]; other site 1001534002497 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1001534002498 AAA domain; Region: AAA_26; pfam13500 1001534002499 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1001534002500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1001534002501 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1001534002502 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1001534002503 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001534002504 catalytic residue [active] 1001534002505 biotin synthase; Region: bioB; TIGR00433 1001534002506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001534002507 FeS/SAM binding site; other site 1001534002508 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1001534002509 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1001534002510 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1001534002511 inhibitor-cofactor binding pocket; inhibition site 1001534002512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001534002513 catalytic residue [active] 1001534002514 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1001534002515 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1001534002516 active site 1001534002517 purine riboside binding site [chemical binding]; other site 1001534002518 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1001534002519 active site 2 [active] 1001534002520 active site 1 [active] 1001534002521 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1001534002522 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1001534002523 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1001534002524 catalytic center binding site [active] 1001534002525 ATP binding site [chemical binding]; other site 1001534002526 dihydropteroate synthase; Region: DHPS; TIGR01496 1001534002527 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1001534002528 substrate binding pocket [chemical binding]; other site 1001534002529 dimer interface [polypeptide binding]; other site 1001534002530 inhibitor binding site; inhibition site 1001534002531 Dihydroneopterin aldolase; Region: FolB; smart00905 1001534002532 active site 1001534002533 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1001534002534 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1001534002535 acyl-activating enzyme (AAE) consensus motif; other site 1001534002536 AMP binding site [chemical binding]; other site 1001534002537 active site 1001534002538 CoA binding site [chemical binding]; other site 1001534002539 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1001534002540 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1001534002541 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1001534002542 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1001534002543 substrate-cofactor binding pocket; other site 1001534002544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001534002545 catalytic residue [active] 1001534002546 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1001534002547 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1001534002548 glutamine binding [chemical binding]; other site 1001534002549 catalytic triad [active] 1001534002550 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001534002551 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001534002552 active site 1001534002553 catalytic tetrad [active] 1001534002554 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1001534002555 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1001534002556 active site 1001534002557 catalytic triad [active] 1001534002558 dimer interface [polypeptide binding]; other site 1001534002559 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1001534002560 GTP cyclohydrolase I; Provisional; Region: PLN03044 1001534002561 active site 1001534002562 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1001534002563 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1001534002564 ATP binding site [chemical binding]; other site 1001534002565 Mg++ binding site [ion binding]; other site 1001534002566 motif III; other site 1001534002567 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001534002568 nucleotide binding region [chemical binding]; other site 1001534002569 ATP-binding site [chemical binding]; other site 1001534002570 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1001534002571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534002572 putative substrate translocation pore; other site 1001534002573 POT family; Region: PTR2; cl17359 1001534002574 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1001534002575 glutathione reductase; Validated; Region: PRK06116 1001534002576 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001534002577 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1001534002578 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1001534002579 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1001534002580 AAA domain; Region: AAA_18; pfam13238 1001534002581 short chain dehydrogenase; Provisional; Region: PRK07577 1001534002582 classical (c) SDRs; Region: SDR_c; cd05233 1001534002583 NAD(P) binding site [chemical binding]; other site 1001534002584 active site 1001534002585 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1001534002586 putative active site [active] 1001534002587 putative catalytic site [active] 1001534002588 putative DNA binding site [nucleotide binding]; other site 1001534002589 putative phosphate binding site [ion binding]; other site 1001534002590 metal binding site A [ion binding]; metal-binding site 1001534002591 putative AP binding site [nucleotide binding]; other site 1001534002592 putative metal binding site B [ion binding]; other site 1001534002593 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1001534002594 active site 1001534002595 Zn binding site [ion binding]; other site 1001534002596 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1001534002597 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1001534002598 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1001534002599 potential catalytic triad [active] 1001534002600 conserved cys residue [active] 1001534002601 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1001534002602 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1001534002603 signal recognition particle protein; Provisional; Region: PRK10867 1001534002604 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1001534002605 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1001534002606 P loop; other site 1001534002607 GTP binding site [chemical binding]; other site 1001534002608 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1001534002609 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1001534002610 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1001534002611 rRNA binding site [nucleotide binding]; other site 1001534002612 predicted 30S ribosome binding site; other site 1001534002613 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1001534002614 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1001534002615 TrkA-N domain; Region: TrkA_N; pfam02254 1001534002616 TrkA-N domain; Region: TrkA_N; pfam02254 1001534002617 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1001534002618 Transcriptional regulator; Region: Rrf2; pfam02082 1001534002619 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1001534002620 putative ABC transporter; Region: ycf24; CHL00085 1001534002621 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1001534002622 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1001534002623 Walker A/P-loop; other site 1001534002624 ATP binding site [chemical binding]; other site 1001534002625 Q-loop/lid; other site 1001534002626 ABC transporter signature motif; other site 1001534002627 Walker B; other site 1001534002628 D-loop; other site 1001534002629 H-loop/switch region; other site 1001534002630 FeS assembly protein SufD; Region: sufD; TIGR01981 1001534002631 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1001534002632 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001534002633 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1001534002634 catalytic residues [active] 1001534002635 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1001534002636 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1001534002637 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1001534002638 hypothetical protein; Provisional; Region: PRK07505 1001534002639 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1001534002640 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001534002641 catalytic residue [active] 1001534002642 PAS fold; Region: PAS_4; pfam08448 1001534002643 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1001534002644 active site 1001534002645 8-oxo-dGMP binding site [chemical binding]; other site 1001534002646 nudix motif; other site 1001534002647 metal binding site [ion binding]; metal-binding site 1001534002648 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 1001534002649 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1001534002650 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1001534002651 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1001534002652 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1001534002653 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1001534002654 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1001534002655 HIGH motif; other site 1001534002656 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1001534002657 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1001534002658 active site 1001534002659 KMSKS motif; other site 1001534002660 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1001534002661 tRNA binding surface [nucleotide binding]; other site 1001534002662 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1001534002663 Lipopolysaccharide-assembly; Region: LptE; cl01125 1001534002664 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1001534002665 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1001534002666 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1001534002667 trimer interface [polypeptide binding]; other site 1001534002668 active site 1001534002669 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 1001534002670 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1001534002671 Walker A motif; other site 1001534002672 metabolite-proton symporter; Region: 2A0106; TIGR00883 1001534002673 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1001534002674 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 1001534002675 putative active site [active] 1001534002676 catalytic site [active] 1001534002677 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 1001534002678 putative active site [active] 1001534002679 catalytic site [active] 1001534002680 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1001534002681 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1001534002682 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1001534002683 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1001534002684 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1001534002685 metal binding site 2 [ion binding]; metal-binding site 1001534002686 putative DNA binding helix; other site 1001534002687 metal binding site 1 [ion binding]; metal-binding site 1001534002688 dimer interface [polypeptide binding]; other site 1001534002689 structural Zn2+ binding site [ion binding]; other site 1001534002690 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1001534002691 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1001534002692 putative tRNA-binding site [nucleotide binding]; other site 1001534002693 B3/4 domain; Region: B3_4; pfam03483 1001534002694 tRNA synthetase B5 domain; Region: B5; smart00874 1001534002695 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1001534002696 dimer interface [polypeptide binding]; other site 1001534002697 motif 1; other site 1001534002698 motif 3; other site 1001534002699 motif 2; other site 1001534002700 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1001534002701 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1001534002702 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1001534002703 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1001534002704 dimer interface [polypeptide binding]; other site 1001534002705 motif 1; other site 1001534002706 active site 1001534002707 motif 2; other site 1001534002708 motif 3; other site 1001534002709 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1001534002710 EamA-like transporter family; Region: EamA; pfam00892 1001534002711 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1001534002712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534002713 MFS/sugar transport protein; Region: MFS_2; pfam13347 1001534002714 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 1001534002715 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001534002716 non-specific DNA binding site [nucleotide binding]; other site 1001534002717 salt bridge; other site 1001534002718 sequence-specific DNA binding site [nucleotide binding]; other site 1001534002719 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 1001534002720 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1001534002721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001534002722 Walker A motif; other site 1001534002723 ATP binding site [chemical binding]; other site 1001534002724 Walker B motif; other site 1001534002725 arginine finger; other site 1001534002726 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1001534002727 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1001534002728 classical (c) SDRs; Region: SDR_c; cd05233 1001534002729 NAD(P) binding site [chemical binding]; other site 1001534002730 active site 1001534002731 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1001534002732 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1001534002733 active site 1001534002734 catalytic triad [active] 1001534002735 oxyanion hole [active] 1001534002736 switch loop; other site 1001534002737 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1001534002738 putative active site pocket [active] 1001534002739 dimerization interface [polypeptide binding]; other site 1001534002740 putative catalytic residue [active] 1001534002741 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1001534002742 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1001534002743 TPP-binding site; other site 1001534002744 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1001534002745 PYR/PP interface [polypeptide binding]; other site 1001534002746 dimer interface [polypeptide binding]; other site 1001534002747 TPP binding site [chemical binding]; other site 1001534002748 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1001534002749 GMP synthase; Reviewed; Region: guaA; PRK00074 1001534002750 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1001534002751 AMP/PPi binding site [chemical binding]; other site 1001534002752 candidate oxyanion hole; other site 1001534002753 catalytic triad [active] 1001534002754 potential glutamine specificity residues [chemical binding]; other site 1001534002755 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1001534002756 ATP Binding subdomain [chemical binding]; other site 1001534002757 Ligand Binding sites [chemical binding]; other site 1001534002758 Dimerization subdomain; other site 1001534002759 amino acid transporter; Region: 2A0306; TIGR00909 1001534002760 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1001534002761 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1001534002762 dimerization interface 3.5A [polypeptide binding]; other site 1001534002763 active site 1001534002764 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1001534002765 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1001534002766 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1001534002767 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1001534002768 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1001534002769 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1001534002770 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1001534002771 Walker A/P-loop; other site 1001534002772 ATP binding site [chemical binding]; other site 1001534002773 Q-loop/lid; other site 1001534002774 ABC transporter signature motif; other site 1001534002775 Walker B; other site 1001534002776 D-loop; other site 1001534002777 H-loop/switch region; other site 1001534002778 OstA-like protein; Region: OstA; cl00844 1001534002779 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1001534002780 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1001534002781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001534002782 active site 1001534002783 motif I; other site 1001534002784 motif II; other site 1001534002785 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1001534002786 dimer interface [polypeptide binding]; other site 1001534002787 substrate binding site [chemical binding]; other site 1001534002788 metal binding sites [ion binding]; metal-binding site 1001534002789 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1001534002790 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1001534002791 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1001534002792 Protein of unknown function (DUF493); Region: DUF493; pfam04359 1001534002793 lipoate-protein ligase B; Provisional; Region: PRK14342 1001534002794 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1001534002795 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001534002796 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1001534002797 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1001534002798 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1001534002799 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1001534002800 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001534002801 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1001534002802 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001534002803 DNA binding residues [nucleotide binding] 1001534002804 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1001534002805 DNA primase; Validated; Region: dnaG; PRK05667 1001534002806 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1001534002807 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1001534002808 active site 1001534002809 metal binding site [ion binding]; metal-binding site 1001534002810 interdomain interaction site; other site 1001534002811 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1001534002812 Yqey-like protein; Region: YqeY; pfam09424 1001534002813 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1001534002814 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1001534002815 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1001534002816 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1001534002817 catalytic residue [active] 1001534002818 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1001534002819 active site 1001534002820 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1001534002821 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1001534002822 Ligand Binding Site [chemical binding]; other site 1001534002823 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1001534002824 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1001534002825 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1001534002826 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1001534002827 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1001534002828 substrate binding pocket [chemical binding]; other site 1001534002829 chain length determination region; other site 1001534002830 substrate-Mg2+ binding site; other site 1001534002831 catalytic residues [active] 1001534002832 aspartate-rich region 1; other site 1001534002833 active site lid residues [active] 1001534002834 aspartate-rich region 2; other site 1001534002835 PQ loop repeat; Region: PQ-loop; cl17546 1001534002836 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1001534002837 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1001534002838 CysD dimerization site [polypeptide binding]; other site 1001534002839 G1 box; other site 1001534002840 putative GEF interaction site [polypeptide binding]; other site 1001534002841 GTP/Mg2+ binding site [chemical binding]; other site 1001534002842 Switch I region; other site 1001534002843 G2 box; other site 1001534002844 G3 box; other site 1001534002845 Switch II region; other site 1001534002846 G4 box; other site 1001534002847 G5 box; other site 1001534002848 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1001534002849 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1001534002850 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1001534002851 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1001534002852 preprotein translocase subunit SecA; Validated; Region: secA; CHL00122 1001534002853 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1001534002854 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001534002855 RNA binding surface [nucleotide binding]; other site 1001534002856 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1001534002857 probable active site [active] 1001534002858 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001534002859 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1001534002860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001534002861 FeS/SAM binding site; other site 1001534002862 replicative DNA helicase; Region: DnaB; TIGR00665 1001534002863 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1001534002864 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1001534002865 Walker A motif; other site 1001534002866 ATP binding site [chemical binding]; other site 1001534002867 Walker B motif; other site 1001534002868 DNA binding loops [nucleotide binding] 1001534002869 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1001534002870 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1001534002871 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1001534002872 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1001534002873 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1001534002874 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1001534002875 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1001534002876 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1001534002877 catalytic core [active] 1001534002878 Abi-like protein; Region: Abi_2; cl01988 1001534002879 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 1001534002880 Antirestriction protein (ArdA); Region: ArdA; pfam07275 1001534002881 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001534002882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001534002883 non-specific DNA binding site [nucleotide binding]; other site 1001534002884 salt bridge; other site 1001534002885 sequence-specific DNA binding site [nucleotide binding]; other site 1001534002886 HipA N-terminal domain; Region: couple_hipA; TIGR03071 1001534002887 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1001534002888 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1001534002889 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1001534002890 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1001534002891 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1001534002892 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1001534002893 active site residue [active] 1001534002894 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1001534002895 S1 domain; Region: S1_2; pfam13509 1001534002896 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1001534002897 Part of AAA domain; Region: AAA_19; pfam13245 1001534002898 AAA domain; Region: AAA_14; pfam13173 1001534002899 Family description; Region: UvrD_C_2; pfam13538 1001534002900 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1001534002901 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1001534002902 Isochorismatase family; Region: Isochorismatase; pfam00857 1001534002903 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1001534002904 catalytic triad [active] 1001534002905 conserved cis-peptide bond; other site 1001534002906 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1001534002907 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1001534002908 Isochorismatase family; Region: Isochorismatase; pfam00857 1001534002909 catalytic triad [active] 1001534002910 conserved cis-peptide bond; other site 1001534002911 transaldolase-like protein; Provisional; Region: PTZ00411 1001534002912 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1001534002913 active site 1001534002914 dimer interface [polypeptide binding]; other site 1001534002915 catalytic residue [active] 1001534002916 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1001534002917 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1001534002918 interface (dimer of trimers) [polypeptide binding]; other site 1001534002919 Substrate-binding/catalytic site; other site 1001534002920 Zn-binding sites [ion binding]; other site 1001534002921 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1001534002922 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1001534002923 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1001534002924 motif 1; other site 1001534002925 active site 1001534002926 motif 2; other site 1001534002927 motif 3; other site 1001534002928 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1001534002929 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1001534002930 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1001534002931 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1001534002932 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1001534002933 catalytic residues [active] 1001534002934 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 1001534002935 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1001534002936 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 1001534002937 TspO/MBR family; Region: TspO_MBR; pfam03073 1001534002938 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1001534002939 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1001534002940 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1001534002941 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1001534002942 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1001534002943 active site 1001534002944 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1001534002945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001534002946 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001534002947 DNA binding residues [nucleotide binding] 1001534002948 Src Homology 3 domain superfamily; Region: SH3; cl17036 1001534002949 peptide ligand binding site [polypeptide binding]; other site 1001534002950 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1001534002951 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1001534002952 Protein export membrane protein; Region: SecD_SecF; pfam02355 1001534002953 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1001534002954 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1001534002955 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1001534002956 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1001534002957 Isochorismatase family; Region: Isochorismatase; pfam00857 1001534002958 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1001534002959 catalytic triad [active] 1001534002960 conserved cis-peptide bond; other site 1001534002961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001534002962 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1001534002963 dimerization interface [polypeptide binding]; other site 1001534002964 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1001534002965 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1001534002966 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 1001534002967 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 1001534002968 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1001534002969 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1001534002970 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1001534002971 Walker A/P-loop; other site 1001534002972 ATP binding site [chemical binding]; other site 1001534002973 Q-loop/lid; other site 1001534002974 ABC transporter signature motif; other site 1001534002975 Walker B; other site 1001534002976 D-loop; other site 1001534002977 H-loop/switch region; other site 1001534002978 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1001534002979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001534002980 dimer interface [polypeptide binding]; other site 1001534002981 conserved gate region; other site 1001534002982 ABC-ATPase subunit interface; other site 1001534002983 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1001534002984 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1001534002985 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1001534002986 aromatic amino acid transport protein; Region: araaP; TIGR00837 1001534002987 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1001534002988 active site residue [active] 1001534002989 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1001534002990 active site residue [active] 1001534002991 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1001534002992 homotrimer interaction site [polypeptide binding]; other site 1001534002993 zinc binding site [ion binding]; other site 1001534002994 CDP-binding sites; other site 1001534002995 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001534002996 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001534002997 cyanophycin synthetase; Provisional; Region: PRK14016 1001534002998 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1001534002999 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001534003000 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001534003001 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1001534003002 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1001534003003 putative MPT binding site; other site 1001534003004 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1001534003005 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1001534003006 active site 1001534003007 catalytic site [active] 1001534003008 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1001534003009 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1001534003010 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1001534003011 Walker A motif; other site 1001534003012 ATP binding site [chemical binding]; other site 1001534003013 Walker B motif; other site 1001534003014 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1001534003015 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1001534003016 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1001534003017 Predicted membrane protein [Function unknown]; Region: COG1511 1001534003018 ferrochelatase; Reviewed; Region: hemH; PRK00035 1001534003019 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1001534003020 C-terminal domain interface [polypeptide binding]; other site 1001534003021 active site 1001534003022 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1001534003023 active site 1001534003024 N-terminal domain interface [polypeptide binding]; other site 1001534003025 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 1001534003026 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1001534003027 Flavoprotein; Region: Flavoprotein; pfam02441 1001534003028 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1001534003029 benzoate transport; Region: 2A0115; TIGR00895 1001534003030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534003031 putative substrate translocation pore; other site 1001534003032 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1001534003033 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 1001534003034 Proline dehydrogenase; Region: Pro_dh; pfam01619 1001534003035 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1001534003036 Glutamate binding site [chemical binding]; other site 1001534003037 NAD binding site [chemical binding]; other site 1001534003038 catalytic residues [active] 1001534003039 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1001534003040 NAD(P) binding site [chemical binding]; other site 1001534003041 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1001534003042 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 1001534003043 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1001534003044 active site 1001534003045 dimer interface [polypeptide binding]; other site 1001534003046 metal binding site [ion binding]; metal-binding site 1001534003047 shikimate kinase; Reviewed; Region: aroK; PRK00131 1001534003048 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1001534003049 ADP binding site [chemical binding]; other site 1001534003050 magnesium binding site [ion binding]; other site 1001534003051 putative shikimate binding site; other site 1001534003052 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1001534003053 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1001534003054 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1001534003055 Pilus assembly protein, PilP; Region: PilP; pfam04351 1001534003056 Pilus assembly protein, PilO; Region: PilO; cl01234 1001534003057 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1001534003058 adenylate kinase; Reviewed; Region: adk; PRK00279 1001534003059 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1001534003060 AMP-binding site [chemical binding]; other site 1001534003061 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1001534003062 GTPase Era; Reviewed; Region: era; PRK00089 1001534003063 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1001534003064 G1 box; other site 1001534003065 GTP/Mg2+ binding site [chemical binding]; other site 1001534003066 Switch I region; other site 1001534003067 G2 box; other site 1001534003068 Switch II region; other site 1001534003069 G3 box; other site 1001534003070 G4 box; other site 1001534003071 G5 box; other site 1001534003072 aspartate aminotransferase; Provisional; Region: PRK05764 1001534003073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001534003074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001534003075 homodimer interface [polypeptide binding]; other site 1001534003076 catalytic residue [active] 1001534003077 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1001534003078 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1001534003079 putative active site [active] 1001534003080 putative dimer interface [polypeptide binding]; other site 1001534003081 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1001534003082 Glycoprotease family; Region: Peptidase_M22; pfam00814 1001534003083 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1001534003084 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1001534003085 active site 1001534003086 dimer interface [polypeptide binding]; other site 1001534003087 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1001534003088 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1001534003089 GTP/Mg2+ binding site [chemical binding]; other site 1001534003090 G4 box; other site 1001534003091 G5 box; other site 1001534003092 G1 box; other site 1001534003093 Switch I region; other site 1001534003094 G2 box; other site 1001534003095 G3 box; other site 1001534003096 Switch II region; other site 1001534003097 Sel1 repeat; Region: Sel1; cl02723 1001534003098 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1001534003099 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1001534003100 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1001534003101 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1001534003102 DNA-binding site [nucleotide binding]; DNA binding site 1001534003103 RNA-binding motif; other site 1001534003104 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1001534003105 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1001534003106 G1 box; other site 1001534003107 putative GEF interaction site [polypeptide binding]; other site 1001534003108 GTP/Mg2+ binding site [chemical binding]; other site 1001534003109 Switch I region; other site 1001534003110 G2 box; other site 1001534003111 G3 box; other site 1001534003112 Switch II region; other site 1001534003113 G4 box; other site 1001534003114 G5 box; other site 1001534003115 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1001534003116 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1001534003117 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1001534003118 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1001534003119 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1001534003120 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 1001534003121 hypothetical protein; Validated; Region: PRK01777 1001534003122 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1001534003123 putative coenzyme Q binding site [chemical binding]; other site 1001534003124 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1001534003125 SmpB-tmRNA interface; other site 1001534003126 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1001534003127 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1001534003128 Ligand Binding Site [chemical binding]; other site 1001534003129 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1001534003130 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1001534003131 generic binding surface II; other site 1001534003132 generic binding surface I; other site 1001534003133 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1001534003134 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1001534003135 metal binding site [ion binding]; metal-binding site 1001534003136 dimer interface [polypeptide binding]; other site 1001534003137 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1001534003138 putative dimer interface [polypeptide binding]; other site 1001534003139 putative active site [active] 1001534003140 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1001534003141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1001534003142 metabolite-proton symporter; Region: 2A0106; TIGR00883 1001534003143 glutamate racemase; Provisional; Region: PRK00865 1001534003144 Nuclease-related domain; Region: NERD; pfam08378 1001534003145 excinuclease ABC subunit B; Provisional; Region: PRK05298 1001534003146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001534003147 ATP binding site [chemical binding]; other site 1001534003148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001534003149 nucleotide binding region [chemical binding]; other site 1001534003150 ATP-binding site [chemical binding]; other site 1001534003151 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1001534003152 UvrB/uvrC motif; Region: UVR; pfam02151 1001534003153 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1001534003154 active site 1001534003155 catalytic site [active] 1001534003156 substrate binding site [chemical binding]; other site 1001534003157 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1001534003158 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1001534003159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001534003160 NAD(P) binding site [chemical binding]; other site 1001534003161 active site 1001534003162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001534003163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001534003164 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1001534003165 putative effector binding pocket; other site 1001534003166 dimerization interface [polypeptide binding]; other site 1001534003167 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1001534003168 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1001534003169 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1001534003170 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1001534003171 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1001534003172 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1001534003173 active site 1001534003174 dimer interface [polypeptide binding]; other site 1001534003175 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1001534003176 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1001534003177 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1001534003178 active site 1001534003179 Zn binding site [ion binding]; other site 1001534003180 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001534003181 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1001534003182 dimer interface [polypeptide binding]; other site 1001534003183 active site 1001534003184 metal binding site [ion binding]; metal-binding site 1001534003185 glutathione binding site [chemical binding]; other site 1001534003186 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 1001534003187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001534003188 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1001534003189 active site 1001534003190 motif I; other site 1001534003191 motif II; other site 1001534003192 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1001534003193 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1001534003194 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1001534003195 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1001534003196 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1001534003197 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1001534003198 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1001534003199 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1001534003200 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1001534003201 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1001534003202 BolA-like protein; Region: BolA; cl00386 1001534003203 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1001534003204 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1001534003205 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1001534003206 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1001534003207 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1001534003208 Recombination protein O N terminal; Region: RecO_N; pfam11967 1001534003209 Recombination protein O C terminal; Region: RecO_C; pfam02565 1001534003210 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1001534003211 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1001534003212 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001534003213 catalytic residue [active] 1001534003214 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1001534003215 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1001534003216 homodimer interface [polypeptide binding]; other site 1001534003217 oligonucleotide binding site [chemical binding]; other site 1001534003218 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1001534003219 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1001534003220 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1001534003221 dimerization interface [polypeptide binding]; other site 1001534003222 active site 1001534003223 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1001534003224 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1001534003225 ligand binding site [chemical binding]; other site 1001534003226 NAD binding site [chemical binding]; other site 1001534003227 tetramer interface [polypeptide binding]; other site 1001534003228 catalytic site [active] 1001534003229 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1001534003230 L-serine binding site [chemical binding]; other site 1001534003231 ACT domain interface; other site 1001534003232 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1001534003233 Ligand Binding Site [chemical binding]; other site 1001534003234 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1001534003235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534003236 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001534003237 putative substrate translocation pore; other site 1001534003238 POT family; Region: PTR2; cl17359 1001534003239 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1001534003240 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1001534003241 active site 1001534003242 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1001534003243 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001534003244 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1001534003245 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1001534003246 Ligand binding site; other site 1001534003247 metal-binding site 1001534003248 hypothetical protein; Provisional; Region: PRK05255 1001534003249 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1001534003250 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1001534003251 dimer interface [polypeptide binding]; other site 1001534003252 active site 1001534003253 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1001534003254 folate binding site [chemical binding]; other site 1001534003255 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1001534003256 FAD binding domain; Region: FAD_binding_4; pfam01565 1001534003257 Berberine and berberine like; Region: BBE; pfam08031 1001534003258 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1001534003259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1001534003260 TPR motif; other site 1001534003261 binding surface 1001534003262 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1001534003263 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001534003264 RNA binding surface [nucleotide binding]; other site 1001534003265 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1001534003266 active site 1001534003267 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1001534003268 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1001534003269 Permease; Region: Permease; pfam02405 1001534003270 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1001534003271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001534003272 Walker A/P-loop; other site 1001534003273 ATP binding site [chemical binding]; other site 1001534003274 Q-loop/lid; other site 1001534003275 ABC transporter signature motif; other site 1001534003276 Walker B; other site 1001534003277 D-loop; other site 1001534003278 H-loop/switch region; other site 1001534003279 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1001534003280 mce related protein; Region: MCE; pfam02470 1001534003281 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1001534003282 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1001534003283 RNA methyltransferase, RsmE family; Region: TIGR00046 1001534003284 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1001534003285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534003286 putative substrate translocation pore; other site 1001534003287 POT family; Region: PTR2; cl17359 1001534003288 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1001534003289 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1001534003290 acyl-activating enzyme (AAE) consensus motif; other site 1001534003291 putative AMP binding site [chemical binding]; other site 1001534003292 putative active site [active] 1001534003293 putative CoA binding site [chemical binding]; other site 1001534003294 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1001534003295 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001534003296 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1001534003297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534003298 putative substrate translocation pore; other site 1001534003299 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1001534003300 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1001534003301 HlyD family secretion protein; Region: HlyD_3; pfam13437 1001534003302 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1001534003303 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1001534003304 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1001534003305 homodimer interface [polypeptide binding]; other site 1001534003306 NAD binding pocket [chemical binding]; other site 1001534003307 ATP binding pocket [chemical binding]; other site 1001534003308 Mg binding site [ion binding]; other site 1001534003309 active-site loop [active] 1001534003310 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1001534003311 Pirin-related protein [General function prediction only]; Region: COG1741 1001534003312 Pirin; Region: Pirin; pfam02678 1001534003313 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001534003314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001534003315 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1001534003316 putative effector binding pocket; other site 1001534003317 dimerization interface [polypeptide binding]; other site 1001534003318 chaperone protein DnaJ; Provisional; Region: PRK10767 1001534003319 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1001534003320 HSP70 interaction site [polypeptide binding]; other site 1001534003321 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1001534003322 substrate binding site [polypeptide binding]; other site 1001534003323 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1001534003324 Zn binding sites [ion binding]; other site 1001534003325 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1001534003326 dimer interface [polypeptide binding]; other site 1001534003327 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1001534003328 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1001534003329 nucleotide binding site [chemical binding]; other site 1001534003330 GrpE; Region: GrpE; pfam01025 1001534003331 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1001534003332 dimer interface [polypeptide binding]; other site 1001534003333 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1001534003334 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1001534003335 MltA specific insert domain; Region: MltA; smart00925 1001534003336 3D domain; Region: 3D; pfam06725 1001534003337 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001534003338 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 1001534003339 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1001534003340 23S rRNA interface [nucleotide binding]; other site 1001534003341 L3 interface [polypeptide binding]; other site 1001534003342 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1001534003343 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1001534003344 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1001534003345 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1001534003346 Na binding site [ion binding]; other site 1001534003347 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1001534003348 RNA/DNA hybrid binding site [nucleotide binding]; other site 1001534003349 active site 1001534003350 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1001534003351 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1001534003352 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1001534003353 active site 1001534003354 phosphorylation site [posttranslational modification] 1001534003355 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1001534003356 30S subunit binding site; other site 1001534003357 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1001534003358 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1001534003359 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1001534003360 G1 box; other site 1001534003361 GTP/Mg2+ binding site [chemical binding]; other site 1001534003362 Switch I region; other site 1001534003363 G2 box; other site 1001534003364 Switch II region; other site 1001534003365 G3 box; other site 1001534003366 G4 box; other site 1001534003367 G5 box; other site 1001534003368 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1001534003369 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001534003370 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001534003371 putative DNA binding site [nucleotide binding]; other site 1001534003372 putative Zn2+ binding site [ion binding]; other site 1001534003373 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1001534003374 dimerization interface [polypeptide binding]; other site 1001534003375 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1001534003376 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1001534003377 dimer interface [polypeptide binding]; other site 1001534003378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001534003379 catalytic residue [active] 1001534003380 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1001534003381 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1001534003382 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1001534003383 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1001534003384 active site 1001534003385 KMSKS motif; other site 1001534003386 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1001534003387 tRNA binding surface [nucleotide binding]; other site 1001534003388 anticodon binding site; other site 1001534003389 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1001534003390 dimer interface [polypeptide binding]; other site 1001534003391 putative tRNA-binding site [nucleotide binding]; other site 1001534003392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534003393 D-galactonate transporter; Region: 2A0114; TIGR00893 1001534003394 putative substrate translocation pore; other site 1001534003395 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1001534003396 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1001534003397 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1001534003398 Intracellular septation protein A; Region: IspA; pfam04279 1001534003399 Glucokinase; Region: Glucokinase; pfam02685 1001534003400 glucokinase, proteobacterial type; Region: glk; TIGR00749 1001534003401 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1001534003402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001534003403 S-adenosylmethionine binding site [chemical binding]; other site 1001534003404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1001534003405 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1001534003406 ABC1 family; Region: ABC1; cl17513 1001534003407 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1001534003408 nucleotide binding site/active site [active] 1001534003409 HIT family signature motif; other site 1001534003410 catalytic residue [active] 1001534003411 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001534003412 active site 1001534003413 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1001534003414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1001534003415 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1001534003416 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1001534003417 FAD binding domain; Region: FAD_binding_4; pfam01565 1001534003418 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1001534003419 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1001534003420 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1001534003421 putative active site [active] 1001534003422 GTP-binding protein Der; Reviewed; Region: PRK00093 1001534003423 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1001534003424 G1 box; other site 1001534003425 GTP/Mg2+ binding site [chemical binding]; other site 1001534003426 Switch I region; other site 1001534003427 G2 box; other site 1001534003428 Switch II region; other site 1001534003429 G3 box; other site 1001534003430 G4 box; other site 1001534003431 G5 box; other site 1001534003432 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1001534003433 G1 box; other site 1001534003434 GTP/Mg2+ binding site [chemical binding]; other site 1001534003435 Switch I region; other site 1001534003436 G2 box; other site 1001534003437 G3 box; other site 1001534003438 Switch II region; other site 1001534003439 G4 box; other site 1001534003440 G5 box; other site 1001534003441 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1001534003442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001534003443 Walker A motif; other site 1001534003444 ATP binding site [chemical binding]; other site 1001534003445 Walker B motif; other site 1001534003446 arginine finger; other site 1001534003447 Peptidase family M41; Region: Peptidase_M41; pfam01434 1001534003448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534003449 putative transporter; Provisional; Region: PRK10504 1001534003450 putative substrate translocation pore; other site 1001534003451 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1001534003452 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1001534003453 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1001534003454 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1001534003455 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1001534003456 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1001534003457 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1001534003458 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1001534003459 Type II transport protein GspH; Region: GspH; pfam12019 1001534003460 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1001534003461 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1001534003462 active site 1001534003463 dimer interface [polypeptide binding]; other site 1001534003464 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1001534003465 dimer interface [polypeptide binding]; other site 1001534003466 active site 1001534003467 Thiamine pyrophosphokinase; Region: TPK; cd07995 1001534003468 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1001534003469 active site 1001534003470 dimerization interface [polypeptide binding]; other site 1001534003471 thiamine binding site [chemical binding]; other site 1001534003472 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1001534003473 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1001534003474 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1001534003475 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1001534003476 active site 1001534003477 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1001534003478 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1001534003479 interface (dimer of trimers) [polypeptide binding]; other site 1001534003480 Substrate-binding/catalytic site; other site 1001534003481 Zn-binding sites [ion binding]; other site 1001534003482 Predicted permeases [General function prediction only]; Region: COG0795 1001534003483 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1001534003484 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1001534003485 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1001534003486 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1001534003487 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1001534003488 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1001534003489 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1001534003490 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1001534003491 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1001534003492 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1001534003493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1001534003494 Predicted membrane protein [Function unknown]; Region: COG2860 1001534003495 UPF0126 domain; Region: UPF0126; pfam03458 1001534003496 UPF0126 domain; Region: UPF0126; pfam03458 1001534003497 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1001534003498 active site 1001534003499 dinuclear metal binding site [ion binding]; other site 1001534003500 dimerization interface [polypeptide binding]; other site 1001534003501 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1001534003502 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1001534003503 active site 1001534003504 catalytic motif [active] 1001534003505 Zn binding site [ion binding]; other site 1001534003506 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1001534003507 FAD binding domain; Region: FAD_binding_4; pfam01565 1001534003508 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1001534003509 phosphoglyceromutase; Provisional; Region: PRK05434 1001534003510 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1001534003511 seryl-tRNA synthetase; Provisional; Region: PRK05431 1001534003512 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1001534003513 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1001534003514 dimer interface [polypeptide binding]; other site 1001534003515 active site 1001534003516 motif 1; other site 1001534003517 motif 2; other site 1001534003518 motif 3; other site 1001534003519 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1001534003520 ROK family; Region: ROK; pfam00480 1001534003521 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1001534003522 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1001534003523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001534003524 Walker A/P-loop; other site 1001534003525 ATP binding site [chemical binding]; other site 1001534003526 Q-loop/lid; other site 1001534003527 ABC transporter signature motif; other site 1001534003528 Walker B; other site 1001534003529 D-loop; other site 1001534003530 H-loop/switch region; other site 1001534003531 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1001534003532 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001534003533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001534003534 Walker A/P-loop; other site 1001534003535 ATP binding site [chemical binding]; other site 1001534003536 Q-loop/lid; other site 1001534003537 ABC transporter signature motif; other site 1001534003538 Walker B; other site 1001534003539 D-loop; other site 1001534003540 H-loop/switch region; other site 1001534003541 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1001534003542 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1001534003543 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1001534003544 homotrimer interaction site [polypeptide binding]; other site 1001534003545 putative active site [active] 1001534003546 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1001534003547 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1001534003548 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1001534003549 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1001534003550 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1001534003551 Peptidase family M50; Region: Peptidase_M50; pfam02163 1001534003552 active site 1001534003553 putative substrate binding region [chemical binding]; other site 1001534003554 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 1001534003555 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 1001534003556 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1001534003557 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 1001534003558 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1001534003559 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1001534003560 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1001534003561 Intracellular growth locus C protein; Region: IglC; pfam11550 1001534003562 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1001534003563 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1001534003564 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 1001534003565 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1001534003566 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1001534003567 intersubunit interface [polypeptide binding]; other site 1001534003568 active site 1001534003569 zinc binding site [ion binding]; other site 1001534003570 Na+ binding site [ion binding]; other site 1001534003571 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1001534003572 pyruvate kinase; Provisional; Region: PRK05826 1001534003573 domain interfaces; other site 1001534003574 active site 1001534003575 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1001534003576 Phosphoglycerate kinase; Region: PGK; pfam00162 1001534003577 substrate binding site [chemical binding]; other site 1001534003578 hinge regions; other site 1001534003579 ADP binding site [chemical binding]; other site 1001534003580 catalytic site [active] 1001534003581 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1001534003582 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1001534003583 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1001534003584 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1001534003585 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1001534003586 TPP-binding site [chemical binding]; other site 1001534003587 dimer interface [polypeptide binding]; other site 1001534003588 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1001534003589 PYR/PP interface [polypeptide binding]; other site 1001534003590 dimer interface [polypeptide binding]; other site 1001534003591 TPP binding site [chemical binding]; other site 1001534003592 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1001534003593 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1001534003594 putative phosphate acyltransferase; Provisional; Region: PRK05331 1001534003595 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1001534003596 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1001534003597 dimer interface [polypeptide binding]; other site 1001534003598 active site 1001534003599 CoA binding pocket [chemical binding]; other site 1001534003600 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1001534003601 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1001534003602 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1001534003603 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1001534003604 NAD(P) binding site [chemical binding]; other site 1001534003605 homotetramer interface [polypeptide binding]; other site 1001534003606 homodimer interface [polypeptide binding]; other site 1001534003607 active site 1001534003608 acyl carrier protein; Provisional; Region: acpP; PRK00982 1001534003609 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1001534003610 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1001534003611 dimer interface [polypeptide binding]; other site 1001534003612 active site 1001534003613 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1001534003614 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1001534003615 active site 1001534003616 dimerization interface [polypeptide binding]; other site 1001534003617 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1001534003618 NusB family; Region: NusB; pfam01029 1001534003619 putative RNA binding site [nucleotide binding]; other site 1001534003620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001534003621 S-adenosylmethionine binding site [chemical binding]; other site 1001534003622 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1001534003623 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1001534003624 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1001534003625 nucleotide binding pocket [chemical binding]; other site 1001534003626 K-X-D-G motif; other site 1001534003627 catalytic site [active] 1001534003628 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1001534003629 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1001534003630 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1001534003631 Dimer interface [polypeptide binding]; other site 1001534003632 BRCT sequence motif; other site 1001534003633 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1001534003634 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1001534003635 active site 1001534003636 oligomerization interface [polypeptide binding]; other site 1001534003637 metal binding site [ion binding]; metal-binding site 1001534003638 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1001534003639 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1001534003640 active site 1001534003641 nucleotide binding site [chemical binding]; other site 1001534003642 HIGH motif; other site 1001534003643 KMSKS motif; other site 1001534003644 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1001534003645 tetramerization interface [polypeptide binding]; other site 1001534003646 active site 1001534003647 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1001534003648 nucleotide binding site [chemical binding]; other site 1001534003649 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1001534003650 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1001534003651 AAA domain; Region: AAA_30; pfam13604 1001534003652 Family description; Region: UvrD_C_2; pfam13538 1001534003653 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1001534003654 Family description; Region: UvrD_C_2; pfam13538 1001534003655 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1001534003656 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1001534003657 Divergent AAA domain; Region: AAA_4; pfam04326 1001534003658 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1001534003659 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001534003660 putative DNA binding site [nucleotide binding]; other site 1001534003661 putative Zn2+ binding site [ion binding]; other site 1001534003662 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1001534003663 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1001534003664 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1001534003665 EamA-like transporter family; Region: EamA; pfam00892 1001534003666 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1001534003667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001534003668 non-specific DNA binding site [nucleotide binding]; other site 1001534003669 salt bridge; other site 1001534003670 sequence-specific DNA binding site [nucleotide binding]; other site 1001534003671 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1001534003672 Catalytic site [active] 1001534003673 FeoA domain; Region: FeoA; cl00838 1001534003674 Sporulation related domain; Region: SPOR; pfam05036 1001534003675 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1001534003676 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1001534003677 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1001534003678 active site 1001534003679 Fe-S metabolism associated domain; Region: SufE; cl00951 1001534003680 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1001534003681 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1001534003682 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1001534003683 dimer interface [polypeptide binding]; other site 1001534003684 motif 1; other site 1001534003685 active site 1001534003686 motif 2; other site 1001534003687 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1001534003688 putative deacylase active site [active] 1001534003689 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1001534003690 active site 1001534003691 motif 3; other site 1001534003692 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1001534003693 anticodon binding site; other site 1001534003694 methionine aminotransferase; Validated; Region: PRK09082 1001534003695 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001534003696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001534003697 homodimer interface [polypeptide binding]; other site 1001534003698 catalytic residue [active] 1001534003699 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1001534003700 C-N hydrolase family amidase; Provisional; Region: PRK10438 1001534003701 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1001534003702 putative active site [active] 1001534003703 catalytic triad [active] 1001534003704 dimer interface [polypeptide binding]; other site 1001534003705 multimer interface [polypeptide binding]; other site 1001534003706 transcription antitermination factor NusB; Region: nusB; TIGR01951 1001534003707 putative RNA binding site [nucleotide binding]; other site 1001534003708 Flagellin N-methylase; Region: FliB; cl00497 1001534003709 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1001534003710 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1001534003711 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1001534003712 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1001534003713 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001534003714 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1001534003715 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1001534003716 active site residue [active] 1001534003717 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1001534003718 active site residue [active] 1001534003719 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001534003720 putative DNA binding site [nucleotide binding]; other site 1001534003721 putative Zn2+ binding site [ion binding]; other site 1001534003722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001534003723 Coenzyme A binding pocket [chemical binding]; other site 1001534003724 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1001534003725 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1001534003726 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1001534003727 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1001534003728 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1001534003729 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1001534003730 Ligand binding site; other site 1001534003731 Putative Catalytic site; other site 1001534003732 DXD motif; other site 1001534003733 inner membrane transport permease; Provisional; Region: PRK15066 1001534003734 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1001534003735 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1001534003736 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1001534003737 Walker A/P-loop; other site 1001534003738 ATP binding site [chemical binding]; other site 1001534003739 Q-loop/lid; other site 1001534003740 ABC transporter signature motif; other site 1001534003741 Walker B; other site 1001534003742 D-loop; other site 1001534003743 H-loop/switch region; other site 1001534003744 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1001534003745 active site 1001534003746 Ferritin-like domain; Region: Ferritin; pfam00210 1001534003747 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1001534003748 dinuclear metal binding motif [ion binding]; other site 1001534003749 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1001534003750 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1001534003751 dimer interface [polypeptide binding]; other site 1001534003752 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1001534003753 recombination factor protein RarA; Provisional; Region: PRK14700 1001534003754 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1001534003755 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1001534003756 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1001534003757 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001534003758 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1001534003759 catalytic residues [active] 1001534003760 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1001534003761 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1001534003762 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1001534003763 RNA binding site [nucleotide binding]; other site 1001534003764 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1001534003765 multimer interface [polypeptide binding]; other site 1001534003766 Walker A motif; other site 1001534003767 ATP binding site [chemical binding]; other site 1001534003768 Walker B motif; other site 1001534003769 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1001534003770 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 1001534003771 active site 1001534003772 substrate binding site [chemical binding]; other site 1001534003773 metal binding site [ion binding]; metal-binding site 1001534003774 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1001534003775 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1001534003776 Substrate binding site; other site 1001534003777 Cupin domain; Region: Cupin_2; cl17218 1001534003778 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1001534003779 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1001534003780 NAD binding site [chemical binding]; other site 1001534003781 substrate binding site [chemical binding]; other site 1001534003782 homodimer interface [polypeptide binding]; other site 1001534003783 active site 1001534003784 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1001534003785 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1001534003786 substrate binding site; other site 1001534003787 tetramer interface; other site 1001534003788 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1001534003789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1001534003790 active site 1001534003791 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1001534003792 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1001534003793 hypothetical protein; Provisional; Region: PRK07579 1001534003794 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1001534003795 active site 1001534003796 cosubstrate binding site; other site 1001534003797 substrate binding site [chemical binding]; other site 1001534003798 catalytic site [active] 1001534003799 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1001534003800 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1001534003801 inhibitor-cofactor binding pocket; inhibition site 1001534003802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001534003803 catalytic residue [active] 1001534003804 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1001534003805 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1001534003806 active site 1001534003807 dimer interface [polypeptide binding]; other site 1001534003808 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1001534003809 Ligand Binding Site [chemical binding]; other site 1001534003810 Molecular Tunnel; other site 1001534003811 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001534003812 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1001534003813 putative ADP-binding pocket [chemical binding]; other site 1001534003814 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 1001534003815 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 1001534003816 NAD binding site [chemical binding]; other site 1001534003817 substrate binding site [chemical binding]; other site 1001534003818 homodimer interface [polypeptide binding]; other site 1001534003819 active site 1001534003820 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1001534003821 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1001534003822 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1001534003823 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001534003824 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1001534003825 putative ADP-binding pocket [chemical binding]; other site 1001534003826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001534003827 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1001534003828 NAD(P) binding site [chemical binding]; other site 1001534003829 active site 1001534003830 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1001534003831 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1001534003832 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1001534003833 NAD(P) binding site [chemical binding]; other site 1001534003834 homodimer interface [polypeptide binding]; other site 1001534003835 substrate binding site [chemical binding]; other site 1001534003836 active site 1001534003837 L-aspartate oxidase; Provisional; Region: PRK09077 1001534003838 L-aspartate oxidase; Provisional; Region: PRK06175 1001534003839 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1001534003840 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1001534003841 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1001534003842 dimerization interface [polypeptide binding]; other site 1001534003843 active site 1001534003844 quinolinate synthetase; Provisional; Region: PRK09375 1001534003845 Guanylate kinase; Region: Guanylate_kin; pfam00625 1001534003846 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1001534003847 catalytic site [active] 1001534003848 G-X2-G-X-G-K; other site 1001534003849 helicase 45; Provisional; Region: PTZ00424 1001534003850 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1001534003851 ATP binding site [chemical binding]; other site 1001534003852 Mg++ binding site [ion binding]; other site 1001534003853 motif III; other site 1001534003854 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001534003855 nucleotide binding region [chemical binding]; other site 1001534003856 ATP-binding site [chemical binding]; other site 1001534003857 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1001534003858 putative RNA binding site [nucleotide binding]; other site 1001534003859 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1001534003860 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1001534003861 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1001534003862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534003863 putative substrate translocation pore; other site 1001534003864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534003865 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1001534003866 putative substrate translocation pore; other site 1001534003867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534003868 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1001534003869 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1001534003870 dimer interface [polypeptide binding]; other site 1001534003871 active site 1001534003872 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1001534003873 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1001534003874 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1001534003875 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1001534003876 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1001534003877 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1001534003878 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1001534003879 Ligand binding site; other site 1001534003880 oligomer interface; other site 1001534003881 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1001534003882 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1001534003883 active site 1001534003884 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1001534003885 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1001534003886 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1001534003887 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001534003888 NAD binding site [chemical binding]; other site 1001534003889 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1001534003890 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1001534003891 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1001534003892 E3 interaction surface; other site 1001534003893 lipoyl attachment site [posttranslational modification]; other site 1001534003894 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1001534003895 E3 interaction surface; other site 1001534003896 lipoyl attachment site [posttranslational modification]; other site 1001534003897 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1001534003898 E3 interaction surface; other site 1001534003899 lipoyl attachment site [posttranslational modification]; other site 1001534003900 e3 binding domain; Region: E3_binding; pfam02817 1001534003901 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1001534003902 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1001534003903 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1001534003904 dimer interface [polypeptide binding]; other site 1001534003905 TPP-binding site [chemical binding]; other site 1001534003906 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 1001534003907 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1001534003908 dephospho-CoA kinase; Region: TIGR00152 1001534003909 CoA-binding site [chemical binding]; other site 1001534003910 ATP-binding [chemical binding]; other site 1001534003911 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1001534003912 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1001534003913 active site 1001534003914 HIGH motif; other site 1001534003915 dimer interface [polypeptide binding]; other site 1001534003916 KMSKS motif; other site 1001534003917 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1001534003918 Zeta toxin; Region: Zeta_toxin; pfam06414 1001534003919 AAA domain; Region: AAA_17; cl17253 1001534003920 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1001534003921 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1001534003922 putative active site [active] 1001534003923 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1001534003924 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1001534003925 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1001534003926 MutS domain I; Region: MutS_I; pfam01624 1001534003927 MutS domain III; Region: MutS_III; pfam05192 1001534003928 MutS domain V; Region: MutS_V; pfam00488 1001534003929 Walker A/P-loop; other site 1001534003930 ATP binding site [chemical binding]; other site 1001534003931 Q-loop/lid; other site 1001534003932 ABC transporter signature motif; other site 1001534003933 Walker B; other site 1001534003934 D-loop; other site 1001534003935 H-loop/switch region; other site 1001534003936 preprotein translocase subunit SecB; Validated; Region: PRK05751 1001534003937 SecA binding site; other site 1001534003938 Preprotein binding site; other site 1001534003939 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1001534003940 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1001534003941 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1001534003942 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1001534003943 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1001534003944 active site 1001534003945 DNA binding site [nucleotide binding] 1001534003946 Int/Topo IB signature motif; other site 1001534003947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001534003948 S-adenosylmethionine binding site [chemical binding]; other site 1001534003949 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1001534003950 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1001534003951 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1001534003952 HD domain; Region: HD_4; pfam13328 1001534003953 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1001534003954 synthetase active site [active] 1001534003955 NTP binding site [chemical binding]; other site 1001534003956 metal binding site [ion binding]; metal-binding site 1001534003957 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1001534003958 Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; Region: PI3Ka; cl00271 1001534003959 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1001534003960 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1001534003961 EamA-like transporter family; Region: EamA; pfam00892 1001534003962 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1001534003963 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1001534003964 HSP70 interaction site [polypeptide binding]; other site 1001534003965 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1001534003966 substrate binding site [polypeptide binding]; other site 1001534003967 dimer interface [polypeptide binding]; other site 1001534003968 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1001534003969 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1001534003970 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1001534003971 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1001534003972 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1001534003973 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1001534003974 DNA binding site [nucleotide binding] 1001534003975 active site 1001534003976 Amino acid permease; Region: AA_permease_2; pfam13520 1001534003977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1001534003978 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1001534003979 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001534003980 ATP binding site [chemical binding]; other site 1001534003981 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1001534003982 putative Mg++ binding site [ion binding]; other site 1001534003983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001534003984 nucleotide binding region [chemical binding]; other site 1001534003985 ATP-binding site [chemical binding]; other site 1001534003986 Helicase associated domain (HA2); Region: HA2; pfam04408 1001534003987 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1001534003988 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1001534003989 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1001534003990 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1001534003991 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1001534003992 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1001534003993 ArsC family; Region: ArsC; pfam03960 1001534003994 catalytic residues [active] 1001534003995 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 1001534003996 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1001534003997 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1001534003998 acyl-activating enzyme (AAE) consensus motif; other site 1001534003999 putative AMP binding site [chemical binding]; other site 1001534004000 putative active site [active] 1001534004001 putative CoA binding site [chemical binding]; other site 1001534004002 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1001534004003 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1001534004004 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1001534004005 active site 1001534004006 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1001534004007 Acyl CoA binding protein; Region: ACBP; pfam00887 1001534004008 acyl-CoA binding pocket [chemical binding]; other site 1001534004009 CoA binding site [chemical binding]; other site 1001534004010 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1001534004011 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1001534004012 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1001534004013 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1001534004014 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1001534004015 substrate binding site [chemical binding]; other site 1001534004016 oxyanion hole (OAH) forming residues; other site 1001534004017 trimer interface [polypeptide binding]; other site 1001534004018 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1001534004019 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1001534004020 dimer interface [polypeptide binding]; other site 1001534004021 active site 1001534004022 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1001534004023 CoenzymeA binding site [chemical binding]; other site 1001534004024 subunit interaction site [polypeptide binding]; other site 1001534004025 PHB binding site; other site 1001534004026 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 1001534004027 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 1001534004028 active site 1001534004029 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 1001534004030 Amidinotransferase; Region: Amidinotransf; pfam02274 1001534004031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 1001534004032 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 1001534004033 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001534004034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001534004035 active site 1001534004036 phosphorylation site [posttranslational modification] 1001534004037 intermolecular recognition site; other site 1001534004038 dimerization interface [polypeptide binding]; other site 1001534004039 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001534004040 DNA binding site [nucleotide binding] 1001534004041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1001534004042 dimer interface [polypeptide binding]; other site 1001534004043 phosphorylation site [posttranslational modification] 1001534004044 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1001534004045 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1001534004046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001534004047 NAD(P) binding site [chemical binding]; other site 1001534004048 active site 1001534004049 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1001534004050 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1001534004051 Di-iron ligands [ion binding]; other site 1001534004052 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1001534004053 ribonuclease R; Region: RNase_R; TIGR02063 1001534004054 RNB domain; Region: RNB; pfam00773 1001534004055 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1001534004056 RNA binding site [nucleotide binding]; other site 1001534004057 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1001534004058 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1001534004059 RNA binding site [nucleotide binding]; other site 1001534004060 active site 1001534004061 ribonuclease III; Reviewed; Region: rnc; PRK00102 1001534004062 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1001534004063 dimerization interface [polypeptide binding]; other site 1001534004064 active site 1001534004065 metal binding site [ion binding]; metal-binding site 1001534004066 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1001534004067 dsRNA binding site [nucleotide binding]; other site 1001534004068 signal peptidase I; Provisional; Region: PRK10861 1001534004069 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1001534004070 Catalytic site [active] 1001534004071 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1001534004072 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001534004073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001534004074 active site 1001534004075 phosphorylation site [posttranslational modification] 1001534004076 intermolecular recognition site; other site 1001534004077 dimerization interface [polypeptide binding]; other site 1001534004078 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001534004079 DNA binding site [nucleotide binding] 1001534004080 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1001534004081 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1001534004082 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1001534004083 active site 1001534004084 dimerization interface [polypeptide binding]; other site 1001534004085 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1001534004086 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1001534004087 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1001534004088 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1001534004089 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1001534004090 substrate binding pocket [chemical binding]; other site 1001534004091 chain length determination region; other site 1001534004092 substrate-Mg2+ binding site; other site 1001534004093 catalytic residues [active] 1001534004094 aspartate-rich region 1; other site 1001534004095 active site lid residues [active] 1001534004096 aspartate-rich region 2; other site 1001534004097 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1001534004098 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1001534004099 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1001534004100 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1001534004101 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1001534004102 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1001534004103 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1001534004104 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1001534004105 active site 1001534004106 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1001534004107 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1001534004108 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1001534004109 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1001534004110 trimer interface [polypeptide binding]; other site 1001534004111 active site 1001534004112 UDP-GlcNAc binding site [chemical binding]; other site 1001534004113 lipid binding site [chemical binding]; lipid-binding site 1001534004114 periplasmic chaperone; Provisional; Region: PRK10780 1001534004115 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1001534004116 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1001534004117 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1001534004118 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1001534004119 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1001534004120 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1001534004121 Surface antigen; Region: Bac_surface_Ag; pfam01103 1001534004122 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1001534004123 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1001534004124 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1001534004125 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1001534004126 DNA gyrase subunit A; Validated; Region: PRK05560 1001534004127 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1001534004128 CAP-like domain; other site 1001534004129 active site 1001534004130 primary dimer interface [polypeptide binding]; other site 1001534004131 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001534004132 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001534004133 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001534004134 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001534004135 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001534004136 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001534004137 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1001534004138 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1001534004139 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1001534004140 ligand binding site [chemical binding]; other site 1001534004141 active site 1001534004142 UGI interface [polypeptide binding]; other site 1001534004143 catalytic site [active] 1001534004144 Restriction endonuclease [Defense mechanisms]; Region: COG3587 1001534004145 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001534004146 ATP binding site [chemical binding]; other site 1001534004147 putative Mg++ binding site [ion binding]; other site 1001534004148 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 1001534004149 GIY-YIG motif/motif A; other site 1001534004150 putative active site [active] 1001534004151 putative metal binding site [ion binding]; other site 1001534004152 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 1001534004153 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1001534004154 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1001534004155 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1001534004156 VacJ like lipoprotein; Region: VacJ; cl01073 1001534004157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001534004158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001534004159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1001534004160 dimerization interface [polypeptide binding]; other site 1001534004161 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1001534004162 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1001534004163 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1001534004164 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1001534004165 ssDNA binding site; other site 1001534004166 generic binding surface II; other site 1001534004167 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001534004168 ATP binding site [chemical binding]; other site 1001534004169 putative Mg++ binding site [ion binding]; other site 1001534004170 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001534004171 nucleotide binding region [chemical binding]; other site 1001534004172 ATP-binding site [chemical binding]; other site 1001534004173 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 1001534004174 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1001534004175 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1001534004176 septum formation inhibitor; Reviewed; Region: minC; PRK04804 1001534004177 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1001534004178 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1001534004179 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1001534004180 Switch I; other site 1001534004181 Switch II; other site 1001534004182 cell division topological specificity factor MinE; Provisional; Region: PRK13990 1001534004183 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1001534004184 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1001534004185 Walker A/P-loop; other site 1001534004186 ATP binding site [chemical binding]; other site 1001534004187 Q-loop/lid; other site 1001534004188 ABC transporter signature motif; other site 1001534004189 Walker B; other site 1001534004190 D-loop; other site 1001534004191 H-loop/switch region; other site 1001534004192 Permease; Region: Permease; pfam02405 1001534004193 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1001534004194 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1001534004195 mce related protein; Region: MCE; pfam02470 1001534004196 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1001534004197 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1001534004198 anti sigma factor interaction site; other site 1001534004199 regulatory phosphorylation site [posttranslational modification]; other site 1001534004200 BolA-like protein; Region: BolA; cl00386 1001534004201 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1001534004202 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1001534004203 active site 1001534004204 HIGH motif; other site 1001534004205 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1001534004206 KMSKS motif; other site 1001534004207 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1001534004208 tRNA binding surface [nucleotide binding]; other site 1001534004209 anticodon binding site; other site 1001534004210 HemK family putative methylases; Region: hemK_fam; TIGR00536 1001534004211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001534004212 S-adenosylmethionine binding site [chemical binding]; other site 1001534004213 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 1001534004214 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1001534004215 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1001534004216 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1001534004217 Domain of unknown function DUF21; Region: DUF21; pfam01595 1001534004218 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1001534004219 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1001534004220 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1001534004221 DXD motif; other site 1001534004222 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1001534004223 Na binding site [ion binding]; other site 1001534004224 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1001534004225 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1001534004226 putative active site [active] 1001534004227 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1001534004228 lysine transporter; Provisional; Region: PRK10836 1001534004229 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1001534004230 active site 1001534004231 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1001534004232 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1001534004233 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1001534004234 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1001534004235 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1001534004236 Cation transport protein; Region: TrkH; cl17365 1001534004237 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1001534004238 ProQ/FINO family; Region: ProQ; pfam04352 1001534004239 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 1001534004240 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1001534004241 substrate binding [chemical binding]; other site 1001534004242 active site 1001534004243 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1001534004244 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001534004245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534004246 putative substrate translocation pore; other site 1001534004247 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 1001534004248 putative active site [active] 1001534004249 dimerization interface [polypeptide binding]; other site 1001534004250 putative tRNAtyr binding site [nucleotide binding]; other site 1001534004251 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1001534004252 phosphate binding site [ion binding]; other site 1001534004253 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1001534004254 active site 1001534004255 dimer interface [polypeptide binding]; other site 1001534004256 Chorismate mutase type II; Region: CM_2; smart00830 1001534004257 SOUL heme-binding protein; Region: SOUL; pfam04832 1001534004258 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001534004259 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001534004260 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1001534004261 dimerization interface [polypeptide binding]; other site 1001534004262 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1001534004263 HlyD family secretion protein; Region: HlyD; pfam00529 1001534004264 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1001534004265 HlyD family secretion protein; Region: HlyD_3; pfam13437 1001534004266 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 1001534004267 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 1001534004268 dihydroorotase; Reviewed; Region: PRK09236 1001534004269 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1001534004270 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1001534004271 active site 1001534004272 thiopurine S-methyltransferase; Reviewed; Region: PRK13256 1001534004273 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1001534004274 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1001534004275 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1001534004276 catalytic site [active] 1001534004277 subunit interface [polypeptide binding]; other site 1001534004278 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1001534004279 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1001534004280 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1001534004281 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1001534004282 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1001534004283 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1001534004284 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1001534004285 substrate binding site [chemical binding]; other site 1001534004286 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1001534004287 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1001534004288 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1001534004289 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1001534004290 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1001534004291 NAD binding site [chemical binding]; other site 1001534004292 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1001534004293 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1001534004294 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1001534004295 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1001534004296 catalytic motif [active] 1001534004297 Zn binding site [ion binding]; other site 1001534004298 RibD C-terminal domain; Region: RibD_C; pfam01872 1001534004299 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1001534004300 Lumazine binding domain; Region: Lum_binding; pfam00677 1001534004301 Lumazine binding domain; Region: Lum_binding; pfam00677 1001534004302 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1001534004303 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1001534004304 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1001534004305 dimerization interface [polypeptide binding]; other site 1001534004306 active site 1001534004307 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1001534004308 homopentamer interface [polypeptide binding]; other site 1001534004309 active site 1001534004310 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1001534004311 active site 1001534004312 catalytic residues [active] 1001534004313 metal binding site [ion binding]; metal-binding site 1001534004314 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1001534004315 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1001534004316 GTP-binding protein LepA; Provisional; Region: PRK05433 1001534004317 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1001534004318 G1 box; other site 1001534004319 putative GEF interaction site [polypeptide binding]; other site 1001534004320 GTP/Mg2+ binding site [chemical binding]; other site 1001534004321 Switch I region; other site 1001534004322 G2 box; other site 1001534004323 G3 box; other site 1001534004324 Switch II region; other site 1001534004325 G4 box; other site 1001534004326 G5 box; other site 1001534004327 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1001534004328 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1001534004329 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1001534004330 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1001534004331 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1001534004332 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1001534004333 dimer interface [polypeptide binding]; other site 1001534004334 active site 1001534004335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534004336 putative substrate translocation pore; other site 1001534004337 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1001534004338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001534004339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001534004340 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1001534004341 putative effector binding pocket; other site 1001534004342 dimerization interface [polypeptide binding]; other site 1001534004343 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1001534004344 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1001534004345 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1001534004346 catalytic residue [active] 1001534004347 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1001534004348 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1001534004349 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1001534004350 aromatic amino acid transport protein; Region: araaP; TIGR00837 1001534004351 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1001534004352 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1001534004353 putative FMN binding site [chemical binding]; other site 1001534004354 hypothetical protein; Validated; Region: PRK02101 1001534004355 Predicted membrane protein [Function unknown]; Region: COG4125 1001534004356 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1001534004357 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1001534004358 oligomerisation interface [polypeptide binding]; other site 1001534004359 mobile loop; other site 1001534004360 roof hairpin; other site 1001534004361 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1001534004362 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1001534004363 ring oligomerisation interface [polypeptide binding]; other site 1001534004364 ATP/Mg binding site [chemical binding]; other site 1001534004365 stacking interactions; other site 1001534004366 hinge regions; other site 1001534004367 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1001534004368 NAD binding site [chemical binding]; other site 1001534004369 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 1001534004370 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1001534004371 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1001534004372 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1001534004373 Intracellular growth locus C protein; Region: IglC; pfam11550 1001534004374 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1001534004375 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1001534004376 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 1001534004377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534004378 putative substrate translocation pore; other site 1001534004379 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1001534004380 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1001534004381 dimerization interface [polypeptide binding]; other site 1001534004382 ATP binding site [chemical binding]; other site 1001534004383 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1001534004384 dimerization interface [polypeptide binding]; other site 1001534004385 ATP binding site [chemical binding]; other site 1001534004386 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1001534004387 putative active site [active] 1001534004388 catalytic triad [active] 1001534004389 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1001534004390 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1001534004391 active site 1001534004392 tetramer interface [polypeptide binding]; other site 1001534004393 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001534004394 active site 1001534004395 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1001534004396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001534004397 catalytic residue [active] 1001534004398 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1001534004399 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1001534004400 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1001534004401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1001534004402 putative protease; Provisional; Region: PRK15452 1001534004403 Peptidase family U32; Region: Peptidase_U32; pfam01136 1001534004404 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1001534004405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534004406 putative substrate translocation pore; other site 1001534004407 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 1001534004408 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1001534004409 Amino acid permease; Region: AA_permease_2; pfam13520 1001534004410 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 1001534004411 GTP1/OBG; Region: GTP1_OBG; pfam01018 1001534004412 Obg GTPase; Region: Obg; cd01898 1001534004413 G1 box; other site 1001534004414 GTP/Mg2+ binding site [chemical binding]; other site 1001534004415 Switch I region; other site 1001534004416 G2 box; other site 1001534004417 G3 box; other site 1001534004418 Switch II region; other site 1001534004419 G4 box; other site 1001534004420 G5 box; other site 1001534004421 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1001534004422 aromatic amino acid transport protein; Region: araaP; TIGR00837 1001534004423 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1001534004424 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1001534004425 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1001534004426 Ligand Binding Site [chemical binding]; other site 1001534004427 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1001534004428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001534004429 dimer interface [polypeptide binding]; other site 1001534004430 phosphorylation site [posttranslational modification] 1001534004431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001534004432 ATP binding site [chemical binding]; other site 1001534004433 Mg2+ binding site [ion binding]; other site 1001534004434 G-X-G motif; other site 1001534004435 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1001534004436 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1001534004437 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1001534004438 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1001534004439 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1001534004440 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1001534004441 dimer interface [polypeptide binding]; other site 1001534004442 PYR/PP interface [polypeptide binding]; other site 1001534004443 TPP binding site [chemical binding]; other site 1001534004444 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1001534004445 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1001534004446 TPP-binding site [chemical binding]; other site 1001534004447 dimer interface [polypeptide binding]; other site 1001534004448 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1001534004449 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1001534004450 tandem repeat interface [polypeptide binding]; other site 1001534004451 oligomer interface [polypeptide binding]; other site 1001534004452 active site residues [active] 1001534004453 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1001534004454 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1001534004455 preprotein translocase subunit SecB; Provisional; Region: PRK13031 1001534004456 SecA binding site; other site 1001534004457 Preprotein binding site; other site 1001534004458 recombinase A; Provisional; Region: recA; PRK09354 1001534004459 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1001534004460 hexamer interface [polypeptide binding]; other site 1001534004461 Walker A motif; other site 1001534004462 ATP binding site [chemical binding]; other site 1001534004463 Walker B motif; other site 1001534004464 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1001534004465 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1001534004466 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1001534004467 dimer interface [polypeptide binding]; other site 1001534004468 ssDNA binding site [nucleotide binding]; other site 1001534004469 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1001534004470 propionate/acetate kinase; Provisional; Region: PRK12379 1001534004471 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1001534004472 phosphate acetyltransferase; Reviewed; Region: PRK05632 1001534004473 DRTGG domain; Region: DRTGG; pfam07085 1001534004474 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1001534004475 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1001534004476 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854 1001534004477 hypothetical protein; Provisional; Region: PRK05421 1001534004478 putative catalytic site [active] 1001534004479 putative metal binding site [ion binding]; other site 1001534004480 putative phosphate binding site [ion binding]; other site 1001534004481 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1001534004482 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1001534004483 putative acyl-acceptor binding pocket; other site 1001534004484 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1001534004485 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1001534004486 putative acyl-acceptor binding pocket; other site 1001534004487 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1001534004488 4Fe-4S binding domain; Region: Fer4; cl02805 1001534004489 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1001534004490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1001534004491 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1001534004492 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1001534004493 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1001534004494 ATP-grasp domain; Region: ATP-grasp; pfam02222 1001534004495 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1001534004496 active site 1001534004497 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1001534004498 Clp amino terminal domain; Region: Clp_N; pfam02861 1001534004499 Clp amino terminal domain; Region: Clp_N; pfam02861 1001534004500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001534004501 Walker A motif; other site 1001534004502 ATP binding site [chemical binding]; other site 1001534004503 Walker B motif; other site 1001534004504 arginine finger; other site 1001534004505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001534004506 Walker A motif; other site 1001534004507 ATP binding site [chemical binding]; other site 1001534004508 Walker B motif; other site 1001534004509 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1001534004510 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1001534004511 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1001534004512 substrate binding site [chemical binding]; other site 1001534004513 active site 1001534004514 catalytic residues [active] 1001534004515 heterodimer interface [polypeptide binding]; other site 1001534004516 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1001534004517 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1001534004518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001534004519 catalytic residue [active] 1001534004520 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1001534004521 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1001534004522 Cl- selectivity filter; other site 1001534004523 Cl- binding residues [ion binding]; other site 1001534004524 pore gating glutamate residue; other site 1001534004525 dimer interface [polypeptide binding]; other site 1001534004526 H+/Cl- coupling transport residue; other site 1001534004527 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1001534004528 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1001534004529 active site 1001534004530 Zn binding site [ion binding]; other site 1001534004531 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1001534004532 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1001534004533 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1001534004534 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1001534004535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001534004536 S-adenosylmethionine binding site [chemical binding]; other site 1001534004537 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1001534004538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001534004539 Walker A/P-loop; other site 1001534004540 ATP binding site [chemical binding]; other site 1001534004541 Q-loop/lid; other site 1001534004542 ABC transporter signature motif; other site 1001534004543 Walker B; other site 1001534004544 D-loop; other site 1001534004545 H-loop/switch region; other site 1001534004546 ABC transporter; Region: ABC_tran_2; pfam12848 1001534004547 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001534004548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001534004549 metabolite-proton symporter; Region: 2A0106; TIGR00883 1001534004550 putative substrate translocation pore; other site 1001534004551 LysE type translocator; Region: LysE; cl00565 1001534004552 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1001534004553 aminopeptidase N; Provisional; Region: pepN; PRK14015 1001534004554 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1001534004555 active site 1001534004556 Zn binding site [ion binding]; other site 1001534004557 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1001534004558 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1001534004559 putative dimer interface [polypeptide binding]; other site 1001534004560 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1001534004561 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1001534004562 active site 1001534004563 ribulose/triose binding site [chemical binding]; other site 1001534004564 phosphate binding site [ion binding]; other site 1001534004565 substrate (anthranilate) binding pocket [chemical binding]; other site 1001534004566 product (indole) binding pocket [chemical binding]; other site 1001534004567 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1001534004568 active site 1001534004569 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1001534004570 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 1001534004571 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1001534004572 anthranilate synthase component I; Provisional; Region: PRK13564 1001534004573 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1001534004574 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1001534004575 Trp repressor protein; Region: Trp_repressor; cl17266 1001534004576 ribonuclease G; Provisional; Region: PRK11712 1001534004577 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1001534004578 homodimer interface [polypeptide binding]; other site 1001534004579 oligonucleotide binding site [chemical binding]; other site