-- dump date   	20140619_095709
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
418136000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
418136000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
418136000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
418136000004	Walker A motif; other site
418136000005	ATP binding site [chemical binding]; other site
418136000006	Walker B motif; other site
418136000007	arginine finger; other site
418136000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
418136000009	DnaA box-binding interface [nucleotide binding]; other site
418136000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
418136000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
418136000012	putative DNA binding surface [nucleotide binding]; other site
418136000013	dimer interface [polypeptide binding]; other site
418136000014	beta-clamp/clamp loader binding surface; other site
418136000015	beta-clamp/translesion DNA polymerase binding surface; other site
418136000016	disruption due to transposon insertion
418136000017	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136000018	Homeodomain-like domain; Region: HTH_23; cl17451
418136000019	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136000020	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136000021	disruption due to transposon insertion
418136000022	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
418136000023	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
418136000024	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
418136000025	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
418136000026	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
418136000027	Cl- selectivity filter; other site
418136000028	Cl- binding residues [ion binding]; other site
418136000029	pore gating glutamate residue; other site
418136000030	dimer interface [polypeptide binding]; other site
418136000031	H+/Cl- coupling transport residue; other site
418136000032	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
418136000033	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
418136000034	active site
418136000035	Zn binding site [ion binding]; other site
418136000036	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
418136000037	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
418136000038	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136000039	catalytic residue [active]
418136000040	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
418136000041	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
418136000042	substrate binding site [chemical binding]; other site
418136000043	active site
418136000044	catalytic residues [active]
418136000045	heterodimer interface [polypeptide binding]; other site
418136000046	contains frameshift
418136000047	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
418136000048	Clp amino terminal domain; Region: Clp_N; pfam02861
418136000049	Clp amino terminal domain; Region: Clp_N; pfam02861
418136000050	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
418136000051	Walker A motif; other site
418136000052	ATP binding site [chemical binding]; other site
418136000053	Walker B motif; other site
418136000054	arginine finger; other site
418136000055	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
418136000056	Walker A motif; other site
418136000057	ATP binding site [chemical binding]; other site
418136000058	Walker B motif; other site
418136000059	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
418136000060	contains frameshift
418136000061	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
418136000062	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
418136000063	ATP-grasp domain; Region: ATP-grasp; pfam02222
418136000064	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
418136000065	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
418136000066	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
418136000067	4Fe-4S binding domain; Region: Fer4; cl02805
418136000068	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
418136000069	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
418136000070	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
418136000071	putative acyl-acceptor binding pocket; other site
418136000072	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
418136000073	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
418136000074	putative acyl-acceptor binding pocket; other site
418136000075	hypothetical protein; Provisional; Region: PRK05421
418136000076	putative catalytic site [active]
418136000077	putative metal binding site [ion binding]; other site
418136000078	putative phosphate binding site [ion binding]; other site
418136000079	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854
418136000080	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
418136000081	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
418136000082	iron-sulfur cluster [ion binding]; other site
418136000083	[2Fe-2S] cluster binding site [ion binding]; other site
418136000084	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
418136000085	contains frameshift
418136000086	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136000087	Homeodomain-like domain; Region: HTH_23; cl17451
418136000088	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136000089	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136000090	disruption due to transposon insertion
418136000091	contains premature stop
418136000092	type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358
418136000093	Protein of unknown function (DUF877); Region: DUF877; pfam05943
418136000094	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
418136000095	Intracellular growth locus C protein; Region: IglC; pfam11550
418136000096	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
418136000097	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
418136000098	RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117
418136000099	disrupted due to transposon insertion
418136000100	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136000101	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136000102	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136000103	disrupted due to transposon insertion
418136000104	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
418136000105	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
418136000106	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
418136000107	Soluble P-type ATPase [General function prediction only]; Region: COG4087
418136000108	K+-transporting ATPase, c chain; Region: KdpC; cl00944
418136000109	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
418136000110	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
418136000111	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
418136000112	Ligand Binding Site [chemical binding]; other site
418136000113	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
418136000114	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
418136000115	dimer interface [polypeptide binding]; other site
418136000116	phosphorylation site [posttranslational modification]
418136000117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
418136000118	ATP binding site [chemical binding]; other site
418136000119	Mg2+ binding site [ion binding]; other site
418136000120	G-X-G motif; other site
418136000121	N-terminal truncated due to frameshift
418136000122	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
418136000123	aromatic amino acid transport protein; Region: araaP; TIGR00837
418136000124	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
418136000125	GTP1/OBG; Region: GTP1_OBG; pfam01018
418136000126	Obg GTPase; Region: Obg; cd01898
418136000127	G1 box; other site
418136000128	GTP/Mg2+ binding site [chemical binding]; other site
418136000129	Switch I region; other site
418136000130	G2 box; other site
418136000131	G3 box; other site
418136000132	Switch II region; other site
418136000133	G4 box; other site
418136000134	G5 box; other site
418136000135	Amino acid permease; Region: AA_permease_2; pfam13520
418136000136	disrupted due to premature stop
418136000137	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
418136000138	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
418136000139	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
418136000140	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136000141	putative substrate translocation pore; other site
418136000142	putative protease; Provisional; Region: PRK15452
418136000143	Peptidase family U32; Region: Peptidase_U32; pfam01136
418136000144	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
418136000145	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
418136000146	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
418136000147	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
418136000148	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
418136000149	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136000150	catalytic residue [active]
418136000151	amidophosphoribosyltransferase; Provisional; Region: PRK09246
418136000152	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
418136000153	active site
418136000154	tetramer interface [polypeptide binding]; other site
418136000155	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
418136000156	active site
418136000157	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
418136000158	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
418136000159	dimerization interface [polypeptide binding]; other site
418136000160	ATP binding site [chemical binding]; other site
418136000161	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
418136000162	dimerization interface [polypeptide binding]; other site
418136000163	ATP binding site [chemical binding]; other site
418136000164	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
418136000165	putative active site [active]
418136000166	catalytic triad [active]
418136000167	contains frameshifts, disrupted due to transposon insertion
418136000168	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136000169	Homeodomain-like domain; Region: HTH_23; cl17451
418136000170	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136000171	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136000172	disrupted due to transpson insertion
418136000173	disrupted due to premature stop
418136000174	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
418136000175	active site
418136000176	catalytic residues [active]
418136000177	adenylosuccinate lyase; Provisional; Region: PRK07492
418136000178	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
418136000179	tetramer interface [polypeptide binding]; other site
418136000180	active site
418136000181	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
418136000182	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
418136000183	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
418136000184	HlyD family secretion protein; Region: HlyD_3; pfam13437
418136000185	Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721
418136000186	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
418136000187	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
418136000188	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
418136000189	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
418136000190	GatB domain; Region: GatB_Yqey; smart00845
418136000191	contains frameshift
418136000192	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
418136000193	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136000194	putative substrate translocation pore; other site
418136000195	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
418136000196	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841
418136000197	dimer interface [polypeptide binding]; other site
418136000198	active site
418136000199	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
418136000200	catalytic residues [active]
418136000201	substrate binding site [chemical binding]; other site
418136000202	Major Facilitator Superfamily; Region: MFS_1; pfam07690
418136000203	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136000204	IucA / IucC family; Region: IucA_IucC; pfam04183
418136000205	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
418136000206	ferric uptake regulator; Provisional; Region: fur; PRK09462
418136000207	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
418136000208	metal binding site 2 [ion binding]; metal-binding site
418136000209	putative DNA binding helix; other site
418136000210	metal binding site 1 [ion binding]; metal-binding site
418136000211	dimer interface [polypeptide binding]; other site
418136000212	structural Zn2+ binding site [ion binding]; other site
418136000213	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
418136000214	NADH dehydrogenase subunit B; Validated; Region: PRK06411
418136000215	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
418136000216	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
418136000217	NADH dehydrogenase subunit D; Validated; Region: PRK06075
418136000218	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
418136000219	NADH dehydrogenase subunit E; Validated; Region: PRK07539
418136000220	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
418136000221	putative dimer interface [polypeptide binding]; other site
418136000222	[2Fe-2S] cluster binding site [ion binding]; other site
418136000223	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
418136000224	SLBB domain; Region: SLBB; pfam10531
418136000225	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
418136000226	NADH dehydrogenase subunit G; Validated; Region: PRK09129
418136000227	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
418136000228	catalytic loop [active]
418136000229	iron binding site [ion binding]; other site
418136000230	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
418136000231	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
418136000232	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
418136000233	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
418136000234	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
418136000235	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
418136000236	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
418136000237	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
418136000238	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
418136000239	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
418136000240	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
418136000241	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
418136000242	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
418136000243	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
418136000244	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
418136000245	Membrane fusogenic activity; Region: BMFP; pfam04380
418136000246	disrupted due to premature stop
418136000247	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
418136000248	substrate binding site [chemical binding]; other site
418136000249	active site
418136000250	ribosome maturation protein RimP; Reviewed; Region: PRK00092
418136000251	hypothetical protein; Provisional; Region: PRK14641
418136000252	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
418136000253	putative oligomer interface [polypeptide binding]; other site
418136000254	putative RNA binding site [nucleotide binding]; other site
418136000255	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
418136000256	NusA N-terminal domain; Region: NusA_N; pfam08529
418136000257	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
418136000258	RNA binding site [nucleotide binding]; other site
418136000259	homodimer interface [polypeptide binding]; other site
418136000260	NusA-like KH domain; Region: KH_5; pfam13184
418136000261	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
418136000262	G-X-X-G motif; other site
418136000263	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
418136000264	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
418136000265	translation initiation factor IF-2; Region: IF-2; TIGR00487
418136000266	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
418136000267	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
418136000268	G1 box; other site
418136000269	putative GEF interaction site [polypeptide binding]; other site
418136000270	GTP/Mg2+ binding site [chemical binding]; other site
418136000271	Switch I region; other site
418136000272	G2 box; other site
418136000273	G3 box; other site
418136000274	Switch II region; other site
418136000275	G4 box; other site
418136000276	G5 box; other site
418136000277	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
418136000278	Translation-initiation factor 2; Region: IF-2; pfam11987
418136000279	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
418136000280	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
418136000281	histidyl-tRNA synthetase; Region: hisS; TIGR00442
418136000282	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
418136000283	dimer interface [polypeptide binding]; other site
418136000284	motif 1; other site
418136000285	active site
418136000286	motif 2; other site
418136000287	motif 3; other site
418136000288	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
418136000289	anticodon binding site; other site
418136000290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136000291	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
418136000292	putative substrate translocation pore; other site
418136000293	Predicted ATPase [General function prediction only]; Region: COG1485
418136000294	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
418136000295	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
418136000296	RNA binding surface [nucleotide binding]; other site
418136000297	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
418136000298	active site
418136000299	Major Facilitator Superfamily; Region: MFS_1; pfam07690
418136000300	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136000301	putative substrate translocation pore; other site
418136000302	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
418136000303	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
418136000304	F0F1 ATP synthase subunit C; Provisional; Region: PRK13464
418136000305	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
418136000306	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
418136000307	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
418136000308	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
418136000309	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
418136000310	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
418136000311	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
418136000312	beta subunit interaction interface [polypeptide binding]; other site
418136000313	Walker A motif; other site
418136000314	ATP binding site [chemical binding]; other site
418136000315	Walker B motif; other site
418136000316	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
418136000317	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
418136000318	core domain interface [polypeptide binding]; other site
418136000319	delta subunit interface [polypeptide binding]; other site
418136000320	epsilon subunit interface [polypeptide binding]; other site
418136000321	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
418136000322	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
418136000323	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
418136000324	alpha subunit interaction interface [polypeptide binding]; other site
418136000325	Walker A motif; other site
418136000326	ATP binding site [chemical binding]; other site
418136000327	Walker B motif; other site
418136000328	inhibitor binding site; inhibition site
418136000329	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
418136000330	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452
418136000331	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
418136000332	gamma subunit interface [polypeptide binding]; other site
418136000333	epsilon subunit interface [polypeptide binding]; other site
418136000334	LBP interface [polypeptide binding]; other site
418136000335	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
418136000336	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
418136000337	putative active site [active]
418136000338	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
418136000339	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
418136000340	putative GSH binding site [chemical binding]; other site
418136000341	catalytic residues [active]
418136000342	superoxide dismutase; Provisional; Region: PRK10543
418136000343	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
418136000344	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
418136000345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136000346	muropeptide transporter; Reviewed; Region: ampG; PRK11902
418136000347	putative substrate translocation pore; other site
418136000348	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
418136000349	dimer interface [polypeptide binding]; other site
418136000350	Citrate synthase; Region: Citrate_synt; pfam00285
418136000351	active site
418136000352	citrylCoA binding site [chemical binding]; other site
418136000353	NADH binding [chemical binding]; other site
418136000354	cationic pore residues; other site
418136000355	oxalacetate/citrate binding site [chemical binding]; other site
418136000356	coenzyme A binding site [chemical binding]; other site
418136000357	catalytic triad [active]
418136000358	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
418136000359	Iron-sulfur protein interface; other site
418136000360	proximal quinone binding site [chemical binding]; other site
418136000361	SdhD (CybS) interface [polypeptide binding]; other site
418136000362	proximal heme binding site [chemical binding]; other site
418136000363	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
418136000364	SdhC subunit interface [polypeptide binding]; other site
418136000365	proximal heme binding site [chemical binding]; other site
418136000366	cardiolipin binding site; other site
418136000367	Iron-sulfur protein interface; other site
418136000368	proximal quinone binding site [chemical binding]; other site
418136000369	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
418136000370	L-aspartate oxidase; Provisional; Region: PRK06175
418136000371	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
418136000372	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
418136000373	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
418136000374	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
418136000375	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
418136000376	TPP-binding site [chemical binding]; other site
418136000377	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
418136000378	dimer interface [polypeptide binding]; other site
418136000379	PYR/PP interface [polypeptide binding]; other site
418136000380	TPP binding site [chemical binding]; other site
418136000381	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
418136000382	E3 interaction surface; other site
418136000383	lipoyl attachment site [posttranslational modification]; other site
418136000384	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
418136000385	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
418136000386	E3 interaction surface; other site
418136000387	lipoyl attachment site [posttranslational modification]; other site
418136000388	e3 binding domain; Region: E3_binding; pfam02817
418136000389	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
418136000390	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
418136000391	nucleotide binding site [chemical binding]; other site
418136000392	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
418136000393	active site
418136000394	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320
418136000395	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
418136000396	active site
418136000397	substrate binding site [chemical binding]; other site
418136000398	metal binding site [ion binding]; metal-binding site
418136000399	triosephosphate isomerase; Provisional; Region: PRK14567
418136000400	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
418136000401	substrate binding site [chemical binding]; other site
418136000402	dimer interface [polypeptide binding]; other site
418136000403	catalytic triad [active]
418136000404	Preprotein translocase SecG subunit; Region: SecG; pfam03840
418136000405	Transcriptional regulator [Transcription]; Region: LysR; COG0583
418136000406	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
418136000407	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
418136000408	HemN family oxidoreductase; Provisional; Region: PRK05660
418136000409	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
418136000410	FeS/SAM binding site; other site
418136000411	HemN C-terminal domain; Region: HemN_C; pfam06969
418136000412	Predicted membrane protein [Function unknown]; Region: COG2246
418136000413	GtrA-like protein; Region: GtrA; pfam04138
418136000414	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
418136000415	aconitate hydratase; Validated; Region: PRK09277
418136000416	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
418136000417	substrate binding site [chemical binding]; other site
418136000418	ligand binding site [chemical binding]; other site
418136000419	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
418136000420	substrate binding site [chemical binding]; other site
418136000421	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
418136000422	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
418136000423	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
418136000424	Walker A motif; other site
418136000425	Walker A/P-loop; other site
418136000426	ATP binding site [chemical binding]; other site
418136000427	ATP binding site [chemical binding]; other site
418136000428	Walker B motif; other site
418136000429	contains frameshift
418136000430	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
418136000431	contains frameshift
418136000432	disruption due to premature stop
418136000433	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
418136000434	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
418136000435	putative NAD(P) binding site [chemical binding]; other site
418136000436	putative active site [active]
418136000437	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
418136000438	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
418136000439	dimer interface [polypeptide binding]; other site
418136000440	phosphorylation site [posttranslational modification]
418136000441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
418136000442	ATP binding site [chemical binding]; other site
418136000443	Mg2+ binding site [ion binding]; other site
418136000444	G-X-G motif; other site
418136000445	ATP-grasp domain; Region: ATP-grasp_4; cl17255
418136000446	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136000447	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136000448	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136000449	Every ISFtu2 ORF in this genome has a premature stop at the identical position resulting in disruption of the ISFtu2 sequence in compariosn to Schu4 ISFtu2 elements.
418136000450	N-terminal truncation
418136000451	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
418136000452	dimer interface [polypeptide binding]; other site
418136000453	catalytic triad [active]
418136000454	disruption due to premature stop
418136000455	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
418136000456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136000457	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
418136000458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136000459	multidrug efflux protein; Reviewed; Region: PRK09579
418136000460	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
418136000461	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
418136000462	HlyD family secretion protein; Region: HlyD_3; pfam13437
418136000463	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
418136000464	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296
418136000465	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
418136000466	active site
418136000467	NTP binding site [chemical binding]; other site
418136000468	metal binding triad [ion binding]; metal-binding site
418136000469	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
418136000470	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
418136000471	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
418136000472	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
418136000473	Walker A/P-loop; other site
418136000474	ATP binding site [chemical binding]; other site
418136000475	Q-loop/lid; other site
418136000476	ABC transporter signature motif; other site
418136000477	Walker B; other site
418136000478	D-loop; other site
418136000479	H-loop/switch region; other site
418136000480	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
418136000481	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
418136000482	DNA polymerase I; Provisional; Region: PRK05755
418136000483	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
418136000484	active site
418136000485	metal binding site 1 [ion binding]; metal-binding site
418136000486	putative 5' ssDNA interaction site; other site
418136000487	metal binding site 3; metal-binding site
418136000488	metal binding site 2 [ion binding]; metal-binding site
418136000489	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
418136000490	putative DNA binding site [nucleotide binding]; other site
418136000491	putative metal binding site [ion binding]; other site
418136000492	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
418136000493	active site
418136000494	catalytic site [active]
418136000495	substrate binding site [chemical binding]; other site
418136000496	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
418136000497	active site
418136000498	DNA binding site [nucleotide binding]
418136000499	catalytic site [active]
418136000500	pantothenate kinase; Reviewed; Region: PRK13324
418136000501	phosphopentomutase; Provisional; Region: PRK05362
418136000502	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
418136000503	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
418136000504	intersubunit interface [polypeptide binding]; other site
418136000505	active site
418136000506	catalytic residue [active]
418136000507	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
418136000508	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
418136000509	Nucleoside recognition; Region: Gate; pfam07670
418136000510	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
418136000511	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
418136000512	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
418136000513	Nucleoside recognition; Region: Gate; pfam07670
418136000514	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
418136000515	thymidylate kinase; Validated; Region: tmk; PRK00698
418136000516	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
418136000517	TMP-binding site; other site
418136000518	ATP-binding site [chemical binding]; other site
418136000519	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
418136000520	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
418136000521	G1 box; other site
418136000522	putative GEF interaction site [polypeptide binding]; other site
418136000523	GTP/Mg2+ binding site [chemical binding]; other site
418136000524	Switch I region; other site
418136000525	G2 box; other site
418136000526	G3 box; other site
418136000527	Switch II region; other site
418136000528	G4 box; other site
418136000529	G5 box; other site
418136000530	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
418136000531	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
418136000532	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
418136000533	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
418136000534	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
418136000535	GTP binding site [chemical binding]; other site
418136000536	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
418136000537	Part of AAA domain; Region: AAA_19; pfam13245
418136000538	Family description; Region: UvrD_C_2; pfam13538
418136000539	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
418136000540	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
418136000541	peptide binding site [polypeptide binding]; other site
418136000542	contains frameshift
418136000543	contains frameshift
418136000544	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
418136000545	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
418136000546	Walker A/P-loop; other site
418136000547	ATP binding site [chemical binding]; other site
418136000548	Q-loop/lid; other site
418136000549	ABC transporter signature motif; other site
418136000550	Walker B; other site
418136000551	D-loop; other site
418136000552	H-loop/switch region; other site
418136000553	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
418136000554	N-terminal truncation due to frameshift
418136000555	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136000556	Major Facilitator Superfamily; Region: MFS_1; pfam07690
418136000557	putative substrate translocation pore; other site
418136000558	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136000559	putative substrate translocation pore; other site
418136000560	Major Facilitator Superfamily; Region: MFS_1; pfam07690
418136000561	glycerol kinase; Provisional; Region: glpK; PRK00047
418136000562	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
418136000563	N- and C-terminal domain interface [polypeptide binding]; other site
418136000564	active site
418136000565	MgATP binding site [chemical binding]; other site
418136000566	catalytic site [active]
418136000567	metal binding site [ion binding]; metal-binding site
418136000568	glycerol binding site [chemical binding]; other site
418136000569	homotetramer interface [polypeptide binding]; other site
418136000570	homodimer interface [polypeptide binding]; other site
418136000571	FBP binding site [chemical binding]; other site
418136000572	protein IIAGlc interface [polypeptide binding]; other site
418136000573	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136000574	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136000575	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136000576	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
418136000577	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
418136000578	amphipathic channel; other site
418136000579	Asn-Pro-Ala signature motifs; other site
418136000580	Mechanosensitive ion channel; Region: MS_channel; pfam00924
418136000581	AAA domain; Region: AAA_30; pfam13604
418136000582	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
418136000583	Family description; Region: UvrD_C_2; pfam13538
418136000584	elongation factor Tu; Reviewed; Region: PRK00049
418136000585	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
418136000586	G1 box; other site
418136000587	GEF interaction site [polypeptide binding]; other site
418136000588	GTP/Mg2+ binding site [chemical binding]; other site
418136000589	Switch I region; other site
418136000590	G2 box; other site
418136000591	G3 box; other site
418136000592	Switch II region; other site
418136000593	G4 box; other site
418136000594	G5 box; other site
418136000595	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
418136000596	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
418136000597	Antibiotic Binding Site [chemical binding]; other site
418136000598	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
418136000599	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
418136000600	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
418136000601	putative homodimer interface [polypeptide binding]; other site
418136000602	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
418136000603	heterodimer interface [polypeptide binding]; other site
418136000604	homodimer interface [polypeptide binding]; other site
418136000605	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
418136000606	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
418136000607	23S rRNA interface [nucleotide binding]; other site
418136000608	L7/L12 interface [polypeptide binding]; other site
418136000609	putative thiostrepton binding site; other site
418136000610	L25 interface [polypeptide binding]; other site
418136000611	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
418136000612	mRNA/rRNA interface [nucleotide binding]; other site
418136000613	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
418136000614	23S rRNA interface [nucleotide binding]; other site
418136000615	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
418136000616	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
418136000617	core dimer interface [polypeptide binding]; other site
418136000618	peripheral dimer interface [polypeptide binding]; other site
418136000619	L10 interface [polypeptide binding]; other site
418136000620	L11 interface [polypeptide binding]; other site
418136000621	putative EF-Tu interaction site [polypeptide binding]; other site
418136000622	putative EF-G interaction site [polypeptide binding]; other site
418136000623	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
418136000624	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
418136000625	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
418136000626	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
418136000627	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
418136000628	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
418136000629	RPB3 interaction site [polypeptide binding]; other site
418136000630	RPB1 interaction site [polypeptide binding]; other site
418136000631	RPB11 interaction site [polypeptide binding]; other site
418136000632	RPB10 interaction site [polypeptide binding]; other site
418136000633	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
418136000634	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
418136000635	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
418136000636	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
418136000637	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
418136000638	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
418136000639	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
418136000640	cleft; other site
418136000641	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
418136000642	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
418136000643	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
418136000644	DNA binding site [nucleotide binding]
418136000645	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
418136000646	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
418136000647	UGMP family protein; Validated; Region: PRK09604
418136000648	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
418136000649	Fatty acid desaturase; Region: FA_desaturase; pfam00487
418136000650	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
418136000651	Di-iron ligands [ion binding]; other site
418136000652	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
418136000653	S-adenosylmethionine synthetase; Validated; Region: PRK05250
418136000654	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
418136000655	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
418136000656	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
418136000657	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
418136000658	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591
418136000659	RimM N-terminal domain; Region: RimM; pfam01782
418136000660	PRC-barrel domain; Region: PRC; pfam05239
418136000661	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
418136000662	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
418136000663	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
418136000664	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
418136000665	active site
418136000666	DNA binding site [nucleotide binding]
418136000667	Int/Topo IB signature motif; other site
418136000668	oxidoreductase, 2OG-Fe(II) oxygenase family protein; Region: PLN03002
418136000669	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
418136000670	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
418136000671	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
418136000672	contains frameshift
418136000673	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
418136000674	putative active site [active]
418136000675	Ap4A binding site [chemical binding]; other site
418136000676	nudix motif; other site
418136000677	putative metal binding site [ion binding]; other site
418136000678	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
418136000679	active site
418136000680	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
418136000681	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
418136000682	amidase catalytic site [active]
418136000683	Zn binding residues [ion binding]; other site
418136000684	substrate binding site [chemical binding]; other site
418136000685	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
418136000686	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
418136000687	Mg2+ binding site [ion binding]; other site
418136000688	G-X-G motif; other site
418136000689	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
418136000690	anchoring element; other site
418136000691	dimer interface [polypeptide binding]; other site
418136000692	ATP binding site [chemical binding]; other site
418136000693	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
418136000694	active site
418136000695	metal binding site [ion binding]; metal-binding site
418136000696	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
418136000697	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136000698	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
418136000699	putative substrate translocation pore; other site
418136000700	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
418136000701	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
418136000702	Trp docking motif [polypeptide binding]; other site
418136000703	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
418136000704	TPR motif; other site
418136000705	binding surface
418136000706	Tetratricopeptide repeat; Region: TPR_16; pfam13432
418136000707	glutamyl-tRNA reductase; Provisional; Region: PRK13940
418136000708	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
418136000709	tRNA; other site
418136000710	putative tRNA binding site [nucleotide binding]; other site
418136000711	putative NADP binding site [chemical binding]; other site
418136000712	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
418136000713	peptide chain release factor 1; Validated; Region: prfA; PRK00591
418136000714	This domain is found in peptide chain release factors; Region: PCRF; smart00937
418136000715	RF-1 domain; Region: RF-1; pfam00472
418136000716	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
418136000717	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
418136000718	disruption due to transposon insertion
418136000719	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136000720	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136000721	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136000722	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
418136000723	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
418136000724	ring oligomerisation interface [polypeptide binding]; other site
418136000725	ATP/Mg binding site [chemical binding]; other site
418136000726	stacking interactions; other site
418136000727	hinge regions; other site
418136000728	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
418136000729	oligomerisation interface [polypeptide binding]; other site
418136000730	mobile loop; other site
418136000731	roof hairpin; other site
418136000732	Predicted membrane protein [Function unknown]; Region: COG4125
418136000733	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
418136000734	hypothetical protein; Validated; Region: PRK02101
418136000735	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136000736	Homeodomain-like domain; Region: HTH_23; cl17451
418136000737	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136000738	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136000739	contains frameshift
418136000740	ProQ/FINO family; Region: ProQ; pfam04352
418136000741	Cation transport protein; Region: TrkH; cl17365
418136000742	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
418136000743	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
418136000744	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
418136000745	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
418136000746	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
418136000747	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
418136000748	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
418136000749	active site
418136000750	lysine transporter; Provisional; Region: PRK10836
418136000751	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
418136000752	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
418136000753	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
418136000754	putative active site [active]
418136000755	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
418136000756	Na binding site [ion binding]; other site
418136000757	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
418136000758	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
418136000759	DXD motif; other site
418136000760	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
418136000761	Domain of unknown function DUF21; Region: DUF21; pfam01595
418136000762	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
418136000763	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
418136000764	contains frameshift
418136000765	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
418136000766	contains frameshifts
418136000767	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136000768	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136000769	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136000770	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
418136000771	Coenzyme A binding pocket [chemical binding]; other site
418136000772	contains frameshift
418136000773	HemK family putative methylases; Region: hemK_fam; TIGR00536
418136000774	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
418136000775	S-adenosylmethionine binding site [chemical binding]; other site
418136000776	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
418136000777	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
418136000778	active site
418136000779	HIGH motif; other site
418136000780	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
418136000781	KMSKS motif; other site
418136000782	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
418136000783	tRNA binding surface [nucleotide binding]; other site
418136000784	anticodon binding site; other site
418136000785	disruption due to transposon
418136000786	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136000787	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136000788	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136000789	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
418136000790	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
418136000791	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
418136000792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
418136000793	VacJ like lipoprotein; Region: VacJ; cl01073
418136000794	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
418136000795	aromatic chitin/cellulose binding site residues [chemical binding]; other site
418136000796	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
418136000797	aromatic chitin/cellulose binding site residues [chemical binding]; other site
418136000798	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
418136000799	active site
418136000800	Transcriptional regulator [Transcription]; Region: LysR; COG0583
418136000801	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
418136000802	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
418136000803	dimerization interface [polypeptide binding]; other site
418136000804	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136000805	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136000806	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136000807	BolA-like protein; Region: BolA; cl00386
418136000808	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
418136000809	anti sigma factor interaction site; other site
418136000810	regulatory phosphorylation site [posttranslational modification]; other site
418136000811	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
418136000812	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
418136000813	mce related protein; Region: MCE; pfam02470
418136000814	Permease; Region: Permease; pfam02405
418136000815	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
418136000816	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
418136000817	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
418136000818	Walker A/P-loop; other site
418136000819	ATP binding site [chemical binding]; other site
418136000820	Q-loop/lid; other site
418136000821	ABC transporter signature motif; other site
418136000822	Walker B; other site
418136000823	D-loop; other site
418136000824	H-loop/switch region; other site
418136000825	cell division topological specificity factor MinE; Provisional; Region: PRK13990
418136000826	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
418136000827	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
418136000828	Switch I; other site
418136000829	Switch II; other site
418136000830	septum formation inhibitor; Reviewed; Region: minC; PRK04804
418136000831	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
418136000832	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
418136000833	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
418136000834	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
418136000835	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627
418136000836	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
418136000837	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
418136000838	ssDNA binding site; other site
418136000839	generic binding surface II; other site
418136000840	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
418136000841	ATP binding site [chemical binding]; other site
418136000842	putative Mg++ binding site [ion binding]; other site
418136000843	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
418136000844	nucleotide binding region [chemical binding]; other site
418136000845	ATP-binding site [chemical binding]; other site
418136000846	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
418136000847	Fumarase C-terminus; Region: Fumerase_C; pfam05683
418136000848	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136000849	Homeodomain-like domain; Region: HTH_23; cl17451
418136000850	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136000851	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136000852	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676
418136000853	contains frameshifts
418136000854	contains frameshift
418136000855	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
418136000856	GIY-YIG motif/motif A; other site
418136000857	putative active site [active]
418136000858	putative metal binding site [ion binding]; other site
418136000859	contains frameshift
418136000860	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
418136000861	ligand binding site [chemical binding]; other site
418136000862	active site
418136000863	UGI interface [polypeptide binding]; other site
418136000864	catalytic site [active]
418136000865	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
418136000866	aromatic chitin/cellulose binding site residues [chemical binding]; other site
418136000867	DNA gyrase subunit A; Validated; Region: PRK05560
418136000868	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
418136000869	CAP-like domain; other site
418136000870	active site
418136000871	primary dimer interface [polypeptide binding]; other site
418136000872	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
418136000873	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
418136000874	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
418136000875	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
418136000876	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
418136000877	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
418136000878	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
418136000879	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
418136000880	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
418136000881	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
418136000882	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
418136000883	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
418136000884	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
418136000885	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
418136000886	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
418136000887	Surface antigen; Region: Bac_surface_Ag; pfam01103
418136000888	periplasmic chaperone; Provisional; Region: PRK10780
418136000889	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
418136000890	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
418136000891	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
418136000892	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
418136000893	trimer interface [polypeptide binding]; other site
418136000894	active site
418136000895	UDP-GlcNAc binding site [chemical binding]; other site
418136000896	lipid binding site [chemical binding]; lipid-binding site
418136000897	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
418136000898	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
418136000899	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
418136000900	active site
418136000901	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
418136000902	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
418136000903	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
418136000904	contains frameshift
418136000905	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
418136000906	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
418136000907	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
418136000908	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
418136000909	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
418136000910	substrate binding pocket [chemical binding]; other site
418136000911	chain length determination region; other site
418136000912	substrate-Mg2+ binding site; other site
418136000913	catalytic residues [active]
418136000914	aspartate-rich region 1; other site
418136000915	active site lid residues [active]
418136000916	aspartate-rich region 2; other site
418136000917	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
418136000918	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
418136000919	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
418136000920	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
418136000921	active site
418136000922	dimerization interface [polypeptide binding]; other site
418136000923	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
418136000924	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
418136000925	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
418136000926	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
418136000927	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
418136000928	active site
418136000929	phosphorylation site [posttranslational modification]
418136000930	intermolecular recognition site; other site
418136000931	dimerization interface [polypeptide binding]; other site
418136000932	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
418136000933	DNA binding site [nucleotide binding]
418136000934	signal peptidase I; Provisional; Region: PRK10861
418136000935	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
418136000936	Catalytic site [active]
418136000937	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
418136000938	ribonuclease III; Reviewed; Region: rnc; PRK00102
418136000939	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
418136000940	dimerization interface [polypeptide binding]; other site
418136000941	active site
418136000942	metal binding site [ion binding]; metal-binding site
418136000943	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
418136000944	dsRNA binding site [nucleotide binding]; other site
418136000945	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
418136000946	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
418136000947	RNA binding site [nucleotide binding]; other site
418136000948	active site
418136000949	ribonuclease R; Region: RNase_R; TIGR02063
418136000950	RNB domain; Region: RNB; pfam00773
418136000951	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
418136000952	RNA binding site [nucleotide binding]; other site
418136000953	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
418136000954	Fatty acid desaturase; Region: FA_desaturase; pfam00487
418136000955	Di-iron ligands [ion binding]; other site
418136000956	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
418136000957	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
418136000958	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
418136000959	NAD(P) binding site [chemical binding]; other site
418136000960	active site
418136000961	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
418136000962	disruption due to transposon insertion
418136000963	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136000964	Homeodomain-like domain; Region: HTH_23; cl17451
418136000965	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136000966	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136000967	disruption due to transposon
418136000968	N-terminal truncation
418136000969	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
418136000970	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
418136000971	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
418136000972	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
418136000973	dimer interface [polypeptide binding]; other site
418136000974	phosphorylation site [posttranslational modification]
418136000975	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
418136000976	ATP binding site [chemical binding]; other site
418136000977	Mg2+ binding site [ion binding]; other site
418136000978	G-X-G motif; other site
418136000979	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
418136000980	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
418136000981	active site
418136000982	phosphorylation site [posttranslational modification]
418136000983	intermolecular recognition site; other site
418136000984	dimerization interface [polypeptide binding]; other site
418136000985	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
418136000986	DNA binding site [nucleotide binding]
418136000987	uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722
418136000988	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
418136000989	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
418136000990	Amidinotransferase; Region: Amidinotransf; pfam02274
418136000991	ornithine cyclodeaminase; Validated; Region: PRK07589
418136000992	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
418136000993	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
418136000994	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
418136000995	active site
418136000996	Protein of unknown function (DUF465); Region: DUF465; pfam04325
418136000997	contains frameshift
418136000998	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
418136000999	CoenzymeA binding site [chemical binding]; other site
418136001000	subunit interaction site [polypeptide binding]; other site
418136001001	PHB binding site; other site
418136001002	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
418136001003	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
418136001004	dimer interface [polypeptide binding]; other site
418136001005	active site
418136001006	Acyl CoA binding protein; Region: ACBP; pfam00887
418136001007	acyl-CoA binding pocket [chemical binding]; other site
418136001008	CoA binding site [chemical binding]; other site
418136001009	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
418136001010	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
418136001011	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
418136001012	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
418136001013	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
418136001014	substrate binding site [chemical binding]; other site
418136001015	oxyanion hole (OAH) forming residues; other site
418136001016	trimer interface [polypeptide binding]; other site
418136001017	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
418136001018	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
418136001019	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
418136001020	active site
418136001021	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
418136001022	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
418136001023	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
418136001024	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
418136001025	acyl-activating enzyme (AAE) consensus motif; other site
418136001026	putative AMP binding site [chemical binding]; other site
418136001027	putative active site [active]
418136001028	putative CoA binding site [chemical binding]; other site
418136001029	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
418136001030	ArsC family; Region: ArsC; pfam03960
418136001031	catalytic residues [active]
418136001032	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
418136001033	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
418136001034	disruption due to premature stop
418136001035	Every ISFtu2 ORF in this genome has a premature stop at the identical position resulting in disruption of the ISFtu2 sequence in compariosn to Schu4 ISFtu2 elements.
418136001036	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
418136001037	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
418136001038	NAD(P) binding site [chemical binding]; other site
418136001039	homodimer interface [polypeptide binding]; other site
418136001040	substrate binding site [chemical binding]; other site
418136001041	active site
418136001042	Bacterial sugar transferase; Region: Bac_transf; pfam02397
418136001043	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
418136001044	NADH(P)-binding; Region: NAD_binding_10; pfam13460
418136001045	NAD(P) binding site [chemical binding]; other site
418136001046	active site
418136001047	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
418136001048	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
418136001049	putative ADP-binding pocket [chemical binding]; other site
418136001050	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
418136001051	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
418136001052	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
418136001053	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
418136001054	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
418136001055	NAD binding site [chemical binding]; other site
418136001056	substrate binding site [chemical binding]; other site
418136001057	homodimer interface [polypeptide binding]; other site
418136001058	active site
418136001059	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
418136001060	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
418136001061	putative ADP-binding pocket [chemical binding]; other site
418136001062	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
418136001063	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
418136001064	active site
418136001065	dimer interface [polypeptide binding]; other site
418136001066	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
418136001067	Ligand Binding Site [chemical binding]; other site
418136001068	Molecular Tunnel; other site
418136001069	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
418136001070	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
418136001071	inhibitor-cofactor binding pocket; inhibition site
418136001072	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136001073	catalytic residue [active]
418136001074	hypothetical protein; Provisional; Region: PRK07579
418136001075	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
418136001076	active site
418136001077	cosubstrate binding site; other site
418136001078	substrate binding site [chemical binding]; other site
418136001079	catalytic site [active]
418136001080	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
418136001081	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
418136001082	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
418136001083	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
418136001084	active site
418136001085	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
418136001086	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
418136001087	substrate binding site; other site
418136001088	tetramer interface; other site
418136001089	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
418136001090	GIY-YIG motif/motif A; other site
418136001091	putative active site [active]
418136001092	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
418136001093	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
418136001094	NAD binding site [chemical binding]; other site
418136001095	substrate binding site [chemical binding]; other site
418136001096	homodimer interface [polypeptide binding]; other site
418136001097	active site
418136001098	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136001099	Homeodomain-like domain; Region: HTH_23; cl17451
418136001100	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136001101	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136001102	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
418136001103	Coenzyme A binding pocket [chemical binding]; other site
418136001104	contains frameshift
418136001105	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
418136001106	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
418136001107	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
418136001108	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
418136001109	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
418136001110	Ligand binding site; other site
418136001111	Putative Catalytic site; other site
418136001112	DXD motif; other site
418136001113	inner membrane transport permease; Provisional; Region: PRK15066
418136001114	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
418136001115	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
418136001116	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
418136001117	Walker A/P-loop; other site
418136001118	ATP binding site [chemical binding]; other site
418136001119	Q-loop/lid; other site
418136001120	ABC transporter signature motif; other site
418136001121	Walker B; other site
418136001122	D-loop; other site
418136001123	H-loop/switch region; other site
418136001124	Every ISFtu2 ORF in this genome has a premature stop at the identical position resulting in disruption of the ISFtu2 sequence in compariosn to Schu4 ISFtu2 elements.
418136001125	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
418136001126	hypothetical protein; Provisional; Region: PRK10621
418136001127	Cupin domain; Region: Cupin_2; cl17218
418136001128	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
418136001129	active site
418136001130	contains frameshift
418136001131	Ferritin-like domain; Region: Ferritin; pfam00210
418136001132	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
418136001133	dinuclear metal binding motif [ion binding]; other site
418136001134	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
418136001135	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
418136001136	dimer interface [polypeptide binding]; other site
418136001137	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
418136001138	recombination factor protein RarA; Provisional; Region: PRK14700
418136001139	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
418136001140	exopolyphosphatase; Region: exo_poly_only; TIGR03706
418136001141	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
418136001142	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
418136001143	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
418136001144	catalytic residues [active]
418136001145	transcription termination factor Rho; Provisional; Region: rho; PRK09376
418136001146	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
418136001147	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
418136001148	RNA binding site [nucleotide binding]; other site
418136001149	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
418136001150	multimer interface [polypeptide binding]; other site
418136001151	Walker A motif; other site
418136001152	ATP binding site [chemical binding]; other site
418136001153	Walker B motif; other site
418136001154	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
418136001155	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
418136001156	active site
418136001157	substrate binding site [chemical binding]; other site
418136001158	metal binding site [ion binding]; metal-binding site
418136001159	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
418136001160	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
418136001161	Substrate binding site; other site
418136001162	Cupin domain; Region: Cupin_2; cl17218
418136001163	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136001164	Homeodomain-like domain; Region: HTH_23; cl17451
418136001165	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136001166	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136001167	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
418136001168	putative DNA binding site [nucleotide binding]; other site
418136001169	putative Zn2+ binding site [ion binding]; other site
418136001170	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
418136001171	active site residue [active]
418136001172	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
418136001173	disruption due to premature stop
418136001174	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
418136001175	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
418136001176	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
418136001177	hypothetical protein; Provisional; Region: PRK05170
418136001178	transcription antitermination factor NusB; Region: nusB; TIGR01951
418136001179	putative RNA binding site [nucleotide binding]; other site
418136001180	C-N hydrolase family amidase; Provisional; Region: PRK10438
418136001181	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
418136001182	putative active site [active]
418136001183	catalytic triad [active]
418136001184	dimer interface [polypeptide binding]; other site
418136001185	multimer interface [polypeptide binding]; other site
418136001186	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
418136001187	methionine aminotransferase; Validated; Region: PRK09082
418136001188	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
418136001189	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136001190	homodimer interface [polypeptide binding]; other site
418136001191	catalytic residue [active]
418136001192	prolyl-tRNA synthetase; Provisional; Region: PRK09194
418136001193	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
418136001194	dimer interface [polypeptide binding]; other site
418136001195	motif 1; other site
418136001196	active site
418136001197	motif 2; other site
418136001198	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
418136001199	putative deacylase active site [active]
418136001200	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
418136001201	active site
418136001202	motif 3; other site
418136001203	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
418136001204	anticodon binding site; other site
418136001205	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
418136001206	Fe-S metabolism associated domain; Region: SufE; cl00951
418136001207	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
418136001208	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
418136001209	active site
418136001210	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
418136001211	Sporulation related domain; Region: SPOR; pfam05036
418136001212	FeoA domain; Region: FeoA; cl00838
418136001213	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
418136001214	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
418136001215	non-specific DNA binding site [nucleotide binding]; other site
418136001216	salt bridge; other site
418136001217	sequence-specific DNA binding site [nucleotide binding]; other site
418136001218	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
418136001219	Catalytic site [active]
418136001220	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
418136001221	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
418136001222	active site
418136001223	FMN binding site [chemical binding]; other site
418136001224	substrate binding site [chemical binding]; other site
418136001225	3Fe-4S cluster binding site [ion binding]; other site
418136001226	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
418136001227	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
418136001228	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
418136001229	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
418136001230	Divergent AAA domain; Region: AAA_4; pfam04326
418136001231	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
418136001232	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
418136001233	putative DNA binding site [nucleotide binding]; other site
418136001234	putative Zn2+ binding site [ion binding]; other site
418136001235	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
418136001236	Family description; Region: UvrD_C_2; pfam13538
418136001237	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
418136001238	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
418136001239	AAA domain; Region: AAA_30; pfam13604
418136001240	Family description; Region: UvrD_C_2; pfam13538
418136001241	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
418136001242	nucleotide binding site [chemical binding]; other site
418136001243	Type III pantothenate kinase; Region: Pan_kinase; cl17198
418136001244	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
418136001245	tetramerization interface [polypeptide binding]; other site
418136001246	active site
418136001247	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
418136001248	pantoate--beta-alanine ligase; Region: panC; TIGR00018
418136001249	active site
418136001250	nucleotide binding site [chemical binding]; other site
418136001251	HIGH motif; other site
418136001252	KMSKS motif; other site
418136001253	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
418136001254	active site
418136001255	oligomerization interface [polypeptide binding]; other site
418136001256	metal binding site [ion binding]; metal-binding site
418136001257	Uncharacterized conserved protein [Function unknown]; Region: COG5495
418136001258	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
418136001259	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
418136001260	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
418136001261	nucleotide binding pocket [chemical binding]; other site
418136001262	K-X-D-G motif; other site
418136001263	catalytic site [active]
418136001264	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
418136001265	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
418136001266	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
418136001267	Dimer interface [polypeptide binding]; other site
418136001268	BRCT sequence motif; other site
418136001269	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136001270	Homeodomain-like domain; Region: HTH_23; cl17451
418136001271	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136001272	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136001273	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
418136001274	16S rRNA methyltransferase B; Provisional; Region: PRK10901
418136001275	NusB family; Region: NusB; pfam01029
418136001276	putative RNA binding site [nucleotide binding]; other site
418136001277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
418136001278	S-adenosylmethionine binding site [chemical binding]; other site
418136001279	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
418136001280	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
418136001281	active site
418136001282	dimerization interface [polypeptide binding]; other site
418136001283	Predicted membrane protein [Function unknown]; Region: COG2855
418136001284	contains frameshifts
418136001285	Uncharacterized conserved protein [Function unknown]; Region: COG4121
418136001286	YCII-related domain; Region: YCII; pfam03795
418136001287	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
418136001288	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
418136001289	dimer interface [polypeptide binding]; other site
418136001290	active site
418136001291	acyl carrier protein; Provisional; Region: acpP; PRK00982
418136001292	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
418136001293	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
418136001294	NAD(P) binding site [chemical binding]; other site
418136001295	homotetramer interface [polypeptide binding]; other site
418136001296	homodimer interface [polypeptide binding]; other site
418136001297	active site
418136001298	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
418136001299	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
418136001300	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
418136001301	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
418136001302	dimer interface [polypeptide binding]; other site
418136001303	active site
418136001304	CoA binding pocket [chemical binding]; other site
418136001305	putative phosphate acyltransferase; Provisional; Region: PRK05331
418136001306	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
418136001307	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
418136001308	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
418136001309	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
418136001310	TPP-binding site [chemical binding]; other site
418136001311	dimer interface [polypeptide binding]; other site
418136001312	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
418136001313	PYR/PP interface [polypeptide binding]; other site
418136001314	dimer interface [polypeptide binding]; other site
418136001315	TPP binding site [chemical binding]; other site
418136001316	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
418136001317	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
418136001318	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
418136001319	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
418136001320	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
418136001321	Phosphoglycerate kinase; Region: PGK; pfam00162
418136001322	substrate binding site [chemical binding]; other site
418136001323	hinge regions; other site
418136001324	ADP binding site [chemical binding]; other site
418136001325	catalytic site [active]
418136001326	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
418136001327	pyruvate kinase; Provisional; Region: PRK05826
418136001328	domain interfaces; other site
418136001329	active site
418136001330	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
418136001331	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
418136001332	intersubunit interface [polypeptide binding]; other site
418136001333	active site
418136001334	zinc binding site [ion binding]; other site
418136001335	Na+ binding site [ion binding]; other site
418136001336	contains frameshift
418136001337	disruption due to transposon insertion
418136001338	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136001339	Homeodomain-like domain; Region: HTH_23; cl17451
418136001340	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136001341	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136001342	disruption due to transposon insertion
418136001343	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
418136001344	type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358
418136001345	Protein of unknown function (DUF877); Region: DUF877; pfam05943
418136001346	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
418136001347	Intracellular growth locus C protein; Region: IglC; pfam11550
418136001348	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
418136001349	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
418136001350	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
418136001351	RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117
418136001352	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
418136001353	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
418136001354	dimer interface [polypeptide binding]; other site
418136001355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136001356	catalytic residue [active]
418136001357	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
418136001358	active site
418136001359	Transcriptional regulator [Transcription]; Region: LysR; COG0583
418136001360	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
418136001361	putative DNA binding site [nucleotide binding]; other site
418136001362	putative Zn2+ binding site [ion binding]; other site
418136001363	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
418136001364	dimerization interface [polypeptide binding]; other site
418136001365	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
418136001366	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
418136001367	trmE is a tRNA modification GTPase; Region: trmE; cd04164
418136001368	G1 box; other site
418136001369	GTP/Mg2+ binding site [chemical binding]; other site
418136001370	Switch I region; other site
418136001371	G2 box; other site
418136001372	Switch II region; other site
418136001373	G3 box; other site
418136001374	G4 box; other site
418136001375	G5 box; other site
418136001376	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
418136001377	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
418136001378	30S subunit binding site; other site
418136001379	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
418136001380	active site
418136001381	phosphorylation site [posttranslational modification]
418136001382	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
418136001383	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
418136001384	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
418136001385	RNA/DNA hybrid binding site [nucleotide binding]; other site
418136001386	active site
418136001387	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
418136001388	Na binding site [ion binding]; other site
418136001389	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
418136001390	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
418136001391	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
418136001392	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
418136001393	23S rRNA interface [nucleotide binding]; other site
418136001394	L3 interface [polypeptide binding]; other site
418136001395	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
418136001396	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
418136001397	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
418136001398	MltA specific insert domain; Region: MltA; smart00925
418136001399	3D domain; Region: 3D; pfam06725
418136001400	GrpE; Region: GrpE; pfam01025
418136001401	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
418136001402	dimer interface [polypeptide binding]; other site
418136001403	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
418136001404	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
418136001405	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
418136001406	nucleotide binding site [chemical binding]; other site
418136001407	chaperone protein DnaJ; Provisional; Region: PRK10767
418136001408	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
418136001409	HSP70 interaction site [polypeptide binding]; other site
418136001410	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
418136001411	substrate binding site [polypeptide binding]; other site
418136001412	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
418136001413	Zn binding sites [ion binding]; other site
418136001414	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
418136001415	dimer interface [polypeptide binding]; other site
418136001416	Transcriptional regulator [Transcription]; Region: LysR; COG0583
418136001417	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
418136001418	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
418136001419	putative effector binding pocket; other site
418136001420	dimerization interface [polypeptide binding]; other site
418136001421	Pirin-related protein [General function prediction only]; Region: COG1741
418136001422	Pirin; Region: Pirin; pfam02678
418136001423	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136001424	Homeodomain-like domain; Region: HTH_23; cl17451
418136001425	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136001426	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136001427	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
418136001428	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
418136001429	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
418136001430	NAD binding site [chemical binding]; other site
418136001431	homotetramer interface [polypeptide binding]; other site
418136001432	homodimer interface [polypeptide binding]; other site
418136001433	substrate binding site [chemical binding]; other site
418136001434	active site
418136001435	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
418136001436	hypothetical protein; Provisional; Region: PRK05409
418136001437	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
418136001438	DoxX; Region: DoxX; pfam07681
418136001439	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
418136001440	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
418136001441	putative active site [active]
418136001442	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
418136001443	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
418136001444	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
418136001445	substrate binding site [chemical binding]; other site
418136001446	hexamer interface [polypeptide binding]; other site
418136001447	metal binding site [ion binding]; metal-binding site
418136001448	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
418136001449	Bacterial sugar transferase; Region: Bac_transf; pfam02397
418136001450	UDP-glucose 4-epimerase; Region: PLN02240
418136001451	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
418136001452	NAD binding site [chemical binding]; other site
418136001453	homodimer interface [polypeptide binding]; other site
418136001454	active site
418136001455	substrate binding site [chemical binding]; other site
418136001456	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
418136001457	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
418136001458	putative ADP-binding pocket [chemical binding]; other site
418136001459	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
418136001460	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
418136001461	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
418136001462	Walker A/P-loop; other site
418136001463	ATP binding site [chemical binding]; other site
418136001464	Q-loop/lid; other site
418136001465	ABC transporter signature motif; other site
418136001466	Walker B; other site
418136001467	D-loop; other site
418136001468	H-loop/switch region; other site
418136001469	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
418136001470	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
418136001471	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
418136001472	active site
418136001473	Methyltransferase domain; Region: Methyltransf_23; pfam13489
418136001474	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
418136001475	S-adenosylmethionine binding site [chemical binding]; other site
418136001476	LicD family; Region: LicD; pfam04991
418136001477	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
418136001478	active site
418136001479	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
418136001480	active site
418136001481	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
418136001482	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
418136001483	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
418136001484	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
418136001485	motif II; other site
418136001486	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
418136001487	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
418136001488	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
418136001489	substrate binding site [chemical binding]; other site
418136001490	ATP binding site [chemical binding]; other site
418136001491	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
418136001492	proposed catalytic triad [active]
418136001493	active site nucleophile [active]
418136001494	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
418136001495	catalytic nucleophile [active]
418136001496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136001497	metabolite-proton symporter; Region: 2A0106; TIGR00883
418136001498	putative substrate translocation pore; other site
418136001499	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
418136001500	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
418136001501	poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011
418136001502	poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332
418136001503	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
418136001504	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
418136001505	Zn2+ binding site [ion binding]; other site
418136001506	Mg2+ binding site [ion binding]; other site
418136001507	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
418136001508	synthetase active site [active]
418136001509	NTP binding site [chemical binding]; other site
418136001510	metal binding site [ion binding]; metal-binding site
418136001511	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
418136001512	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
418136001513	recombination protein RecR; Provisional; Region: PRK13844
418136001514	RecR protein; Region: RecR; pfam02132
418136001515	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
418136001516	putative active site [active]
418136001517	putative metal-binding site [ion binding]; other site
418136001518	tetramer interface [polypeptide binding]; other site
418136001519	hypothetical protein; Validated; Region: PRK00153
418136001520	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
418136001521	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
418136001522	homodimer interface [polypeptide binding]; other site
418136001523	active site
418136001524	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
418136001525	lipoyl attachment site [posttranslational modification]; other site
418136001526	Chitin binding domain; Region: Chitin_bind_3; pfam03067
418136001527	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
418136001528	aromatic chitin/cellulose binding site residues [chemical binding]; other site
418136001529	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
418136001530	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
418136001531	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
418136001532	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
418136001533	active site
418136001534	dimer interface [polypeptide binding]; other site
418136001535	motif 1; other site
418136001536	motif 2; other site
418136001537	motif 3; other site
418136001538	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
418136001539	anticodon binding site; other site
418136001540	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
418136001541	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
418136001542	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
418136001543	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
418136001544	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
418136001545	23S rRNA binding site [nucleotide binding]; other site
418136001546	L21 binding site [polypeptide binding]; other site
418136001547	L13 binding site [polypeptide binding]; other site
418136001548	Uncharacterized conserved protein [Function unknown]; Region: COG0398
418136001549	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
418136001550	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136001551	Homeodomain-like domain; Region: HTH_23; cl17451
418136001552	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136001553	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136001554	Uncharacterized conserved protein [Function unknown]; Region: COG2835
418136001555	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
418136001556	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
418136001557	Ligand binding site; other site
418136001558	oligomer interface; other site
418136001559	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
418136001560	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
418136001561	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
418136001562	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
418136001563	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
418136001564	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
418136001565	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
418136001566	dimer interface [polypeptide binding]; other site
418136001567	active site
418136001568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136001569	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
418136001570	putative substrate translocation pore; other site
418136001571	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136001572	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
418136001573	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136001574	putative substrate translocation pore; other site
418136001575	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
418136001576	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
418136001577	helicase 45; Provisional; Region: PTZ00424
418136001578	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
418136001579	ATP binding site [chemical binding]; other site
418136001580	Mg++ binding site [ion binding]; other site
418136001581	motif III; other site
418136001582	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
418136001583	nucleotide binding region [chemical binding]; other site
418136001584	ATP-binding site [chemical binding]; other site
418136001585	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
418136001586	putative RNA binding site [nucleotide binding]; other site
418136001587	Guanylate kinase; Region: Guanylate_kin; pfam00625
418136001588	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
418136001589	catalytic site [active]
418136001590	G-X2-G-X-G-K; other site
418136001591	quinolinate synthetase; Provisional; Region: PRK09375
418136001592	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
418136001593	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
418136001594	dimerization interface [polypeptide binding]; other site
418136001595	active site
418136001596	L-aspartate oxidase; Provisional; Region: PRK09077
418136001597	L-aspartate oxidase; Provisional; Region: PRK06175
418136001598	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
418136001599	contains frameshift
418136001600	Every ISFtu2 ORF in this genome has a premature stop at the identical position resulting in disruption of the ISFtu2 sequence in compariosn to Schu4 ISFtu2 elements.
418136001601	Chorismate mutase type II; Region: CM_2; smart00830
418136001602	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
418136001603	catalytic residues [active]
418136001604	dimer interface [polypeptide binding]; other site
418136001605	disruption due to premature stop
418136001606	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
418136001607	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
418136001608	active site
418136001609	Putative serine esterase (DUF676); Region: DUF676; pfam05057
418136001610	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
418136001611	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
418136001612	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
418136001613	putative substrate binding site [chemical binding]; other site
418136001614	putative ATP binding site [chemical binding]; other site
418136001615	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
418136001616	RNA binding surface [nucleotide binding]; other site
418136001617	contains frameshift and premature stop
418136001618	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
418136001619	Fusaric acid resistance protein family; Region: FUSC; pfam04632
418136001620	contains frameshift
418136001621	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
418136001622	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
418136001623	HlyD family secretion protein; Region: HlyD_3; pfam13437
418136001624	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
418136001625	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
418136001626	non-specific DNA interactions [nucleotide binding]; other site
418136001627	DNA binding site [nucleotide binding]
418136001628	sequence specific DNA binding site [nucleotide binding]; other site
418136001629	putative cAMP binding site [chemical binding]; other site
418136001630	Bacterial transcriptional regulator; Region: IclR; pfam01614
418136001631	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
418136001632	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
418136001633	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
418136001634	Radical SAM superfamily; Region: Radical_SAM; pfam04055
418136001635	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
418136001636	FeS/SAM binding site; other site
418136001637	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
418136001638	DNA-binding site [nucleotide binding]; DNA binding site
418136001639	RNA-binding motif; other site
418136001640	contains frameshift
418136001641	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
418136001642	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
418136001643	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
418136001644	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
418136001645	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
418136001646	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
418136001647	active site
418136001648	tetramer interface; other site
418136001649	contains frameshift
418136001650	EamA-like transporter family; Region: EamA; pfam00892
418136001651	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
418136001652	EamA-like transporter family; Region: EamA; pfam00892
418136001653	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
418136001654	recombination protein F; Reviewed; Region: recF; PRK00064
418136001655	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
418136001656	Walker A/P-loop; other site
418136001657	ATP binding site [chemical binding]; other site
418136001658	Q-loop/lid; other site
418136001659	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
418136001660	ABC transporter signature motif; other site
418136001661	Walker B; other site
418136001662	D-loop; other site
418136001663	H-loop/switch region; other site
418136001664	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
418136001665	active site
418136001666	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
418136001667	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
418136001668	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136001669	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136001670	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136001671	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
418136001672	ISFtu2 fragment resulting from frameshift and premature stop
418136001673	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136001674	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136001675	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136001676	contains frameshift
418136001677	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
418136001678	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
418136001679	homodimer interface [polypeptide binding]; other site
418136001680	NAD binding pocket [chemical binding]; other site
418136001681	ATP binding pocket [chemical binding]; other site
418136001682	Mg binding site [ion binding]; other site
418136001683	active-site loop [active]
418136001684	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
418136001685	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
418136001686	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
418136001687	HlyD family secretion protein; Region: HlyD_3; pfam13437
418136001688	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
418136001689	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136001690	putative substrate translocation pore; other site
418136001691	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
418136001692	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
418136001693	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
418136001694	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
418136001695	acyl-activating enzyme (AAE) consensus motif; other site
418136001696	putative AMP binding site [chemical binding]; other site
418136001697	putative active site [active]
418136001698	putative CoA binding site [chemical binding]; other site
418136001699	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
418136001700	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136001701	putative substrate translocation pore; other site
418136001702	POT family; Region: PTR2; cl17359
418136001703	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
418136001704	RNA methyltransferase, RsmE family; Region: TIGR00046
418136001705	Protein of unknown function (DUF445); Region: DUF445; pfam04286
418136001706	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
418136001707	mce related protein; Region: MCE; pfam02470
418136001708	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
418136001709	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
418136001710	Walker A/P-loop; other site
418136001711	ATP binding site [chemical binding]; other site
418136001712	Q-loop/lid; other site
418136001713	ABC transporter signature motif; other site
418136001714	Walker B; other site
418136001715	D-loop; other site
418136001716	H-loop/switch region; other site
418136001717	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
418136001718	Permease; Region: Permease; pfam02405
418136001719	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
418136001720	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
418136001721	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
418136001722	RNA binding surface [nucleotide binding]; other site
418136001723	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
418136001724	active site
418136001725	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
418136001726	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
418136001727	TPR motif; other site
418136001728	binding surface
418136001729	disruption due to premature stop
418136001730	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
418136001731	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
418136001732	dimer interface [polypeptide binding]; other site
418136001733	active site
418136001734	glycine-pyridoxal phosphate binding site [chemical binding]; other site
418136001735	folate binding site [chemical binding]; other site
418136001736	hypothetical protein; Provisional; Region: PRK05255
418136001737	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
418136001738	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
418136001739	Ligand binding site; other site
418136001740	metal-binding site
418136001741	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
418136001742	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
418136001743	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
418136001744	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
418136001745	active site
418136001746	contains frameshift and deletion
418136001747	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136001748	Homeodomain-like domain; Region: HTH_23; cl17451
418136001749	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136001750	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136001751	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
418136001752	Ligand Binding Site [chemical binding]; other site
418136001753	TilS substrate C-terminal domain; Region: TilS_C; smart00977
418136001754	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
418136001755	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
418136001756	ligand binding site [chemical binding]; other site
418136001757	NAD binding site [chemical binding]; other site
418136001758	tetramer interface [polypeptide binding]; other site
418136001759	catalytic site [active]
418136001760	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
418136001761	L-serine binding site [chemical binding]; other site
418136001762	ACT domain interface; other site
418136001763	thymidylate synthase; Reviewed; Region: thyA; PRK01827
418136001764	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
418136001765	dimerization interface [polypeptide binding]; other site
418136001766	active site
418136001767	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
418136001768	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
418136001769	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
418136001770	homodimer interface [polypeptide binding]; other site
418136001771	oligonucleotide binding site [chemical binding]; other site
418136001772	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
418136001773	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
418136001774	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
418136001775	catalytic residue [active]
418136001776	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
418136001777	Recombination protein O N terminal; Region: RecO_N; pfam11967
418136001778	Recombination protein O C terminal; Region: RecO_C; pfam02565
418136001779	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
418136001780	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
418136001781	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
418136001782	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
418136001783	BolA-like protein; Region: BolA; cl00386
418136001784	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
418136001785	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
418136001786	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
418136001787	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
418136001788	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
418136001789	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
418136001790	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
418136001791	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
418136001792	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
418136001793	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
418136001794	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
418136001795	active site
418136001796	motif I; other site
418136001797	motif II; other site
418136001798	Soluble P-type ATPase [General function prediction only]; Region: COG4087
418136001799	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
418136001800	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
418136001801	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
418136001802	dimer interface [polypeptide binding]; other site
418136001803	active site
418136001804	metal binding site [ion binding]; metal-binding site
418136001805	glutathione binding site [chemical binding]; other site
418136001806	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136001807	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136001808	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136001809	GTP-binding protein Der; Reviewed; Region: PRK00093
418136001810	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
418136001811	G1 box; other site
418136001812	GTP/Mg2+ binding site [chemical binding]; other site
418136001813	Switch I region; other site
418136001814	G2 box; other site
418136001815	Switch II region; other site
418136001816	G3 box; other site
418136001817	G4 box; other site
418136001818	G5 box; other site
418136001819	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
418136001820	G1 box; other site
418136001821	GTP/Mg2+ binding site [chemical binding]; other site
418136001822	Switch I region; other site
418136001823	G2 box; other site
418136001824	G3 box; other site
418136001825	Switch II region; other site
418136001826	G4 box; other site
418136001827	G5 box; other site
418136001828	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
418136001829	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
418136001830	putative active site [active]
418136001831	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
418136001832	FAD binding domain; Region: FAD_binding_4; pfam01565
418136001833	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
418136001834	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
418136001835	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
418136001836	contains frameshift and premature stop
418136001837	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
418136001838	nucleotide binding site/active site [active]
418136001839	HIT family signature motif; other site
418136001840	catalytic residue [active]
418136001841	ABC1 family; Region: ABC1; cl17513
418136001842	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
418136001843	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
418136001844	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
418136001845	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
418136001846	S-adenosylmethionine binding site [chemical binding]; other site
418136001847	Glucokinase; Region: Glucokinase; pfam02685
418136001848	glucokinase, proteobacterial type; Region: glk; TIGR00749
418136001849	Intracellular septation protein A; Region: IspA; pfam04279
418136001850	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
418136001851	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
418136001852	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
418136001853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136001854	D-galactonate transporter; Region: 2A0114; TIGR00893
418136001855	putative substrate translocation pore; other site
418136001856	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
418136001857	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
418136001858	active site
418136001859	HIGH motif; other site
418136001860	KMSKS motif; other site
418136001861	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
418136001862	tRNA binding surface [nucleotide binding]; other site
418136001863	anticodon binding site; other site
418136001864	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
418136001865	dimer interface [polypeptide binding]; other site
418136001866	putative tRNA-binding site [nucleotide binding]; other site
418136001867	Predicted flavoprotein [General function prediction only]; Region: COG0431
418136001868	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
418136001869	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
418136001870	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
418136001871	Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931
418136001872	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
418136001873	Peptidase family M50; Region: Peptidase_M50; pfam02163
418136001874	active site
418136001875	putative substrate binding region [chemical binding]; other site
418136001876	Every ISFtu2 ORF in this genome has a premature stop at the identical position resulting in disruption of the ISFtu2 sequence in compariosn to Schu4 ISFtu2 elements.
418136001877	glutamate dehydrogenase; Provisional; Region: PRK09414
418136001878	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
418136001879	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
418136001880	NAD(P) binding site [chemical binding]; other site
418136001881	Every ISFtu2 ORF in this genome has a premature stop at the identical position resulting in disruption of the ISFtu2 sequence in compariosn to Schu4 ISFtu2 elements.
418136001882	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
418136001883	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
418136001884	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
418136001885	active site
418136001886	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
418136001887	substrate binding site [chemical binding]; other site
418136001888	catalytic residues [active]
418136001889	dimer interface [polypeptide binding]; other site
418136001890	Amino acid permease; Region: AA_permease_2; pfam13520
418136001891	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
418136001892	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
418136001893	DNA binding site [nucleotide binding]
418136001894	active site
418136001895	contains frameshift
418136001896	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
418136001897	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
418136001898	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
418136001899	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
418136001900	HSP70 interaction site [polypeptide binding]; other site
418136001901	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
418136001902	substrate binding site [polypeptide binding]; other site
418136001903	dimer interface [polypeptide binding]; other site
418136001904	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
418136001905	EamA-like transporter family; Region: EamA; pfam00892
418136001906	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
418136001907	Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; Region: PI3Ka; cl00271
418136001908	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
418136001909	HD domain; Region: HD_4; pfam13328
418136001910	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
418136001911	synthetase active site [active]
418136001912	NTP binding site [chemical binding]; other site
418136001913	metal binding site [ion binding]; metal-binding site
418136001914	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
418136001915	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
418136001916	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
418136001917	contains frameshift
418136001918	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
418136001919	S-adenosylmethionine binding site [chemical binding]; other site
418136001920	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
418136001921	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
418136001922	active site
418136001923	DNA binding site [nucleotide binding]
418136001924	Int/Topo IB signature motif; other site
418136001925	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
418136001926	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
418136001927	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
418136001928	preprotein translocase subunit SecB; Validated; Region: PRK05751
418136001929	SecA binding site; other site
418136001930	Preprotein binding site; other site
418136001931	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
418136001932	MutS domain I; Region: MutS_I; pfam01624
418136001933	MutS domain III; Region: MutS_III; pfam05192
418136001934	MutS domain V; Region: MutS_V; pfam00488
418136001935	Walker A/P-loop; other site
418136001936	ATP binding site [chemical binding]; other site
418136001937	Q-loop/lid; other site
418136001938	ABC transporter signature motif; other site
418136001939	Walker B; other site
418136001940	D-loop; other site
418136001941	H-loop/switch region; other site
418136001942	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
418136001943	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
418136001944	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
418136001945	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
418136001946	putative active site [active]
418136001947	Zeta toxin; Region: Zeta_toxin; pfam06414
418136001948	AAA domain; Region: AAA_17; cl17253
418136001949	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
418136001950	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
418136001951	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
418136001952	active site
418136001953	HIGH motif; other site
418136001954	dimer interface [polypeptide binding]; other site
418136001955	KMSKS motif; other site
418136001956	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
418136001957	dephospho-CoA kinase; Region: TIGR00152
418136001958	CoA-binding site [chemical binding]; other site
418136001959	ATP-binding [chemical binding]; other site
418136001960	Uncharacterized conserved protein [Function unknown]; Region: COG1565
418136001961	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
418136001962	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
418136001963	dimer interface [polypeptide binding]; other site
418136001964	TPP-binding site [chemical binding]; other site
418136001965	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
418136001966	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
418136001967	E3 interaction surface; other site
418136001968	lipoyl attachment site [posttranslational modification]; other site
418136001969	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
418136001970	E3 interaction surface; other site
418136001971	lipoyl attachment site [posttranslational modification]; other site
418136001972	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
418136001973	E3 interaction surface; other site
418136001974	lipoyl attachment site [posttranslational modification]; other site
418136001975	e3 binding domain; Region: E3_binding; pfam02817
418136001976	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
418136001977	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
418136001978	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
418136001979	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
418136001980	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
418136001981	NAD binding site [chemical binding]; other site
418136001982	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
418136001983	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136001984	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136001985	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136001986	contains frameshift
418136001987	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
418136001988	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
418136001989	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
418136001990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
418136001991	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
418136001992	S-adenosylmethionine binding site [chemical binding]; other site
418136001993	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
418136001994	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
418136001995	putative active site [active]
418136001996	substrate binding site [chemical binding]; other site
418136001997	putative cosubstrate binding site; other site
418136001998	catalytic site [active]
418136001999	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
418136002000	substrate binding site [chemical binding]; other site
418136002001	glutathione synthetase; Provisional; Region: PRK05246
418136002002	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
418136002003	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
418136002004	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
418136002005	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
418136002006	inhibitor-cofactor binding pocket; inhibition site
418136002007	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136002008	catalytic residue [active]
418136002009	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
418136002010	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
418136002011	disruption due to premature stop
418136002012	contains frameshift
418136002013	contains frameshift
418136002014	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
418136002015	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
418136002016	nucleotide binding site [chemical binding]; other site
418136002017	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
418136002018	dimerization interface [polypeptide binding]; other site
418136002019	putative DNA binding site [nucleotide binding]; other site
418136002020	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
418136002021	putative Zn2+ binding site [ion binding]; other site
418136002022	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
418136002023	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
418136002024	AAA domain; Region: AAA_26; pfam13500
418136002025	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
418136002026	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
418136002027	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
418136002028	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
418136002029	catalytic residue [active]
418136002030	biotin synthase; Region: bioB; TIGR00433
418136002031	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
418136002032	FeS/SAM binding site; other site
418136002033	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
418136002034	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
418136002035	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
418136002036	inhibitor-cofactor binding pocket; inhibition site
418136002037	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136002038	catalytic residue [active]
418136002039	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
418136002040	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
418136002041	active site
418136002042	purine riboside binding site [chemical binding]; other site
418136002043	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
418136002044	active site 2 [active]
418136002045	active site 1 [active]
418136002046	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
418136002047	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
418136002048	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
418136002049	catalytic center binding site [active]
418136002050	ATP binding site [chemical binding]; other site
418136002051	dihydropteroate synthase; Region: DHPS; TIGR01496
418136002052	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
418136002053	substrate binding pocket [chemical binding]; other site
418136002054	dimer interface [polypeptide binding]; other site
418136002055	inhibitor binding site; inhibition site
418136002056	Dihydroneopterin aldolase; Region: FolB; smart00905
418136002057	active site
418136002058	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
418136002059	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
418136002060	acyl-activating enzyme (AAE) consensus motif; other site
418136002061	AMP binding site [chemical binding]; other site
418136002062	active site
418136002063	CoA binding site [chemical binding]; other site
418136002064	aminodeoxychorismate synthase; Provisional; Region: PRK07508
418136002065	chorismate binding enzyme; Region: Chorismate_bind; cl10555
418136002066	Aminotransferase class IV; Region: Aminotran_4; pfam01063
418136002067	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
418136002068	substrate-cofactor binding pocket; other site
418136002069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136002070	catalytic residue [active]
418136002071	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
418136002072	Glutamine amidotransferase class-I; Region: GATase; pfam00117
418136002073	glutamine binding [chemical binding]; other site
418136002074	catalytic triad [active]
418136002075	contains frameshift and premature stop
418136002076	contains frameshift
418136002077	Predicted amidohydrolase [General function prediction only]; Region: COG0388
418136002078	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
418136002079	active site
418136002080	catalytic triad [active]
418136002081	dimer interface [polypeptide binding]; other site
418136002082	contains frameshift
418136002083	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
418136002084	GTP cyclohydrolase I; Provisional; Region: PLN03044
418136002085	active site
418136002086	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
418136002087	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
418136002088	ATP binding site [chemical binding]; other site
418136002089	Mg++ binding site [ion binding]; other site
418136002090	motif III; other site
418136002091	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
418136002092	nucleotide binding region [chemical binding]; other site
418136002093	ATP-binding site [chemical binding]; other site
418136002094	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
418136002095	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136002096	putative substrate translocation pore; other site
418136002097	POT family; Region: PTR2; cl17359
418136002098	Uncharacterized conserved protein [Function unknown]; Region: COG0393
418136002099	glutathione reductase; Validated; Region: PRK06116
418136002100	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
418136002101	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
418136002102	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
418136002103	disruption due to premature stop
418136002104	short chain dehydrogenase; Provisional; Region: PRK07577
418136002105	classical (c) SDRs; Region: SDR_c; cd05233
418136002106	NAD(P) binding site [chemical binding]; other site
418136002107	active site
418136002108	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
418136002109	putative active site [active]
418136002110	putative catalytic site [active]
418136002111	putative DNA binding site [nucleotide binding]; other site
418136002112	putative phosphate binding site [ion binding]; other site
418136002113	metal binding site A [ion binding]; metal-binding site
418136002114	putative AP binding site [nucleotide binding]; other site
418136002115	putative metal binding site B [ion binding]; other site
418136002116	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
418136002117	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
418136002118	active site
418136002119	Zn binding site [ion binding]; other site
418136002120	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
418136002121	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
418136002122	intracellular protease, PfpI family; Region: PfpI; TIGR01382
418136002123	potential catalytic triad [active]
418136002124	conserved cys residue [active]
418136002125	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
418136002126	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
418136002127	signal recognition particle protein; Provisional; Region: PRK10867
418136002128	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
418136002129	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
418136002130	P loop; other site
418136002131	GTP binding site [chemical binding]; other site
418136002132	Signal peptide binding domain; Region: SRP_SPB; pfam02978
418136002133	contains frameshift
418136002134	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
418136002135	rRNA binding site [nucleotide binding]; other site
418136002136	predicted 30S ribosome binding site; other site
418136002137	contains frameshift
418136002138	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
418136002139	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
418136002140	TrkA-N domain; Region: TrkA_N; pfam02254
418136002141	TrkA-N domain; Region: TrkA_N; pfam02254
418136002142	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
418136002143	Transcriptional regulator; Region: Rrf2; pfam02082
418136002144	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
418136002145	putative ABC transporter; Region: ycf24; CHL00085
418136002146	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
418136002147	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
418136002148	Walker A/P-loop; other site
418136002149	ATP binding site [chemical binding]; other site
418136002150	Q-loop/lid; other site
418136002151	ABC transporter signature motif; other site
418136002152	Walker B; other site
418136002153	D-loop; other site
418136002154	H-loop/switch region; other site
418136002155	FeS assembly protein SufD; Region: sufD; TIGR01981
418136002156	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
418136002157	disruption due to premature stop
418136002158	contains frameshift
418136002159	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
418136002160	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
418136002161	catalytic residues [active]
418136002162	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
418136002163	Transcriptional regulators [Transcription]; Region: MarR; COG1846
418136002164	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
418136002165	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
418136002166	hypothetical protein; Provisional; Region: PRK07505
418136002167	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
418136002168	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
418136002169	catalytic residue [active]
418136002170	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
418136002171	PAS fold; Region: PAS_4; pfam08448
418136002172	contains frameshift
418136002173	contains frameshift
418136002174	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
418136002175	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
418136002176	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
418136002177	Sel1 repeat; Region: Sel1; cl02723
418136002178	contains frameshift
418136002179	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
418136002180	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
418136002181	HIGH motif; other site
418136002182	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
418136002183	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
418136002184	active site
418136002185	KMSKS motif; other site
418136002186	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
418136002187	tRNA binding surface [nucleotide binding]; other site
418136002188	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
418136002189	Lipopolysaccharide-assembly; Region: LptE; cl01125
418136002190	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
418136002191	Mechanosensitive ion channel; Region: MS_channel; pfam00924
418136002192	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
418136002193	trimer interface [polypeptide binding]; other site
418136002194	active site
418136002195	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
418136002196	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
418136002197	Walker A motif; other site
418136002198	metabolite-proton symporter; Region: 2A0106; TIGR00883
418136002199	contains frameshift
418136002200	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
418136002201	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156
418136002202	putative active site [active]
418136002203	catalytic site [active]
418136002204	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162
418136002205	putative active site [active]
418136002206	catalytic site [active]
418136002207	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
418136002208	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
418136002209	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
418136002210	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
418136002211	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
418136002212	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
418136002213	metal binding site 2 [ion binding]; metal-binding site
418136002214	putative DNA binding helix; other site
418136002215	metal binding site 1 [ion binding]; metal-binding site
418136002216	dimer interface [polypeptide binding]; other site
418136002217	structural Zn2+ binding site [ion binding]; other site
418136002218	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
418136002219	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
418136002220	putative tRNA-binding site [nucleotide binding]; other site
418136002221	B3/4 domain; Region: B3_4; pfam03483
418136002222	tRNA synthetase B5 domain; Region: B5; smart00874
418136002223	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
418136002224	dimer interface [polypeptide binding]; other site
418136002225	motif 1; other site
418136002226	motif 3; other site
418136002227	motif 2; other site
418136002228	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
418136002229	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
418136002230	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
418136002231	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
418136002232	dimer interface [polypeptide binding]; other site
418136002233	motif 1; other site
418136002234	active site
418136002235	motif 2; other site
418136002236	motif 3; other site
418136002237	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
418136002238	EamA-like transporter family; Region: EamA; pfam00892
418136002239	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
418136002240	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136002241	MFS/sugar transport protein; Region: MFS_2; pfam13347
418136002242	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
418136002243	catalytic motif [active]
418136002244	Catalytic residue [active]
418136002245	Aspartyl protease; Region: Asp_protease_2; pfam13650
418136002246	inhibitor binding site; inhibition site
418136002247	catalytic motif [active]
418136002248	Catalytic residue [active]
418136002249	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
418136002250	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
418136002251	non-specific DNA binding site [nucleotide binding]; other site
418136002252	salt bridge; other site
418136002253	sequence-specific DNA binding site [nucleotide binding]; other site
418136002254	contains frameshift
418136002255	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
418136002256	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
418136002257	Walker A motif; other site
418136002258	ATP binding site [chemical binding]; other site
418136002259	Walker B motif; other site
418136002260	arginine finger; other site
418136002261	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
418136002262	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
418136002263	classical (c) SDRs; Region: SDR_c; cd05233
418136002264	NAD(P) binding site [chemical binding]; other site
418136002265	active site
418136002266	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
418136002267	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
418136002268	active site
418136002269	catalytic triad [active]
418136002270	oxyanion hole [active]
418136002271	switch loop; other site
418136002272	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
418136002273	putative active site pocket [active]
418136002274	dimerization interface [polypeptide binding]; other site
418136002275	putative catalytic residue [active]
418136002276	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
418136002277	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
418136002278	TPP-binding site; other site
418136002279	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
418136002280	PYR/PP interface [polypeptide binding]; other site
418136002281	dimer interface [polypeptide binding]; other site
418136002282	TPP binding site [chemical binding]; other site
418136002283	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
418136002284	GMP synthase; Reviewed; Region: guaA; PRK00074
418136002285	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
418136002286	AMP/PPi binding site [chemical binding]; other site
418136002287	candidate oxyanion hole; other site
418136002288	catalytic triad [active]
418136002289	potential glutamine specificity residues [chemical binding]; other site
418136002290	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
418136002291	ATP Binding subdomain [chemical binding]; other site
418136002292	Ligand Binding sites [chemical binding]; other site
418136002293	Dimerization subdomain; other site
418136002294	amino acid transporter; Region: 2A0306; TIGR00909
418136002295	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
418136002296	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
418136002297	dimerization interface 3.5A [polypeptide binding]; other site
418136002298	active site
418136002299	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
418136002300	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
418136002301	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
418136002302	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
418136002303	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
418136002304	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
418136002305	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
418136002306	Walker A/P-loop; other site
418136002307	ATP binding site [chemical binding]; other site
418136002308	Q-loop/lid; other site
418136002309	ABC transporter signature motif; other site
418136002310	Walker B; other site
418136002311	D-loop; other site
418136002312	H-loop/switch region; other site
418136002313	OstA-like protein; Region: OstA; cl00844
418136002314	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
418136002315	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
418136002316	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
418136002317	active site
418136002318	motif I; other site
418136002319	motif II; other site
418136002320	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
418136002321	dimer interface [polypeptide binding]; other site
418136002322	substrate binding site [chemical binding]; other site
418136002323	metal binding sites [ion binding]; metal-binding site
418136002324	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
418136002325	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
418136002326	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
418136002327	Protein of unknown function (DUF493); Region: DUF493; pfam04359
418136002328	lipoate-protein ligase B; Provisional; Region: PRK14342
418136002329	disrupted due to premature stop
418136002330	disruption due to premature stop
418136002331	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
418136002332	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
418136002333	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
418136002334	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
418136002335	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
418136002336	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
418136002337	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
418136002338	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
418136002339	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
418136002340	DNA binding residues [nucleotide binding]
418136002341	CHC2 zinc finger; Region: zf-CHC2; pfam01807
418136002342	DNA primase; Validated; Region: dnaG; PRK05667
418136002343	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
418136002344	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
418136002345	active site
418136002346	metal binding site [ion binding]; metal-binding site
418136002347	interdomain interaction site; other site
418136002348	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
418136002349	Yqey-like protein; Region: YqeY; pfam09424
418136002350	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
418136002351	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
418136002352	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
418136002353	N-acetyl-D-glucosamine binding site [chemical binding]; other site
418136002354	catalytic residue [active]
418136002355	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
418136002356	active site
418136002357	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
418136002358	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
418136002359	Ligand Binding Site [chemical binding]; other site
418136002360	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
418136002361	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
418136002362	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
418136002363	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
418136002364	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
418136002365	substrate binding pocket [chemical binding]; other site
418136002366	chain length determination region; other site
418136002367	substrate-Mg2+ binding site; other site
418136002368	catalytic residues [active]
418136002369	aspartate-rich region 1; other site
418136002370	active site lid residues [active]
418136002371	aspartate-rich region 2; other site
418136002372	PQ loop repeat; Region: PQ-loop; cl17546
418136002373	shikimate kinase; Reviewed; Region: aroK; PRK00131
418136002374	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
418136002375	ligand-binding site [chemical binding]; other site
418136002376	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
418136002377	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
418136002378	CysD dimerization site [polypeptide binding]; other site
418136002379	G1 box; other site
418136002380	putative GEF interaction site [polypeptide binding]; other site
418136002381	GTP/Mg2+ binding site [chemical binding]; other site
418136002382	Switch I region; other site
418136002383	G2 box; other site
418136002384	G3 box; other site
418136002385	Switch II region; other site
418136002386	G4 box; other site
418136002387	G5 box; other site
418136002388	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
418136002389	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
418136002390	contains frameshift
418136002391	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
418136002392	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
418136002393	Coenzyme A binding pocket [chemical binding]; other site
418136002394	preprotein translocase subunit SecA; Validated; Region: secA; CHL00122
418136002395	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
418136002396	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
418136002397	RNA binding surface [nucleotide binding]; other site
418136002398	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
418136002399	probable active site [active]
418136002400	Tetratricopeptide repeat; Region: TPR_12; pfam13424
418136002401	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
418136002402	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
418136002403	FeS/SAM binding site; other site
418136002404	replicative DNA helicase; Region: DnaB; TIGR00665
418136002405	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
418136002406	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
418136002407	Walker A motif; other site
418136002408	ATP binding site [chemical binding]; other site
418136002409	Walker B motif; other site
418136002410	DNA binding loops [nucleotide binding]
418136002411	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
418136002412	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
418136002413	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
418136002414	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
418136002415	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
418136002416	ISFtu2 fragment resulting from frameshift and premature stop
418136002417	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
418136002418	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
418136002419	disruption due to transposon insertion
418136002420	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136002421	Homeodomain-like domain; Region: HTH_23; cl17451
418136002422	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136002423	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136002424	disruption due to transposon insertion
418136002425	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
418136002426	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
418136002427	catalytic residue [active]
418136002428	cytidylate kinase; Provisional; Region: cmk; PRK00023
418136002429	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
418136002430	CMP-binding site; other site
418136002431	The sites determining sugar specificity; other site
418136002432	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
418136002433	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
418136002434	putative NAD(P) binding site [chemical binding]; other site
418136002435	homodimer interface [polypeptide binding]; other site
418136002436	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
418136002437	catalytic triad [active]
418136002438	dimer interface [polypeptide binding]; other site
418136002439	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
418136002440	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
418136002441	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
418136002442	dimerization interface [polypeptide binding]; other site
418136002443	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
418136002444	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
418136002445	putative homodimer interface [polypeptide binding]; other site
418136002446	putative homotetramer interface [polypeptide binding]; other site
418136002447	putative allosteric switch controlling residues; other site
418136002448	putative metal binding site [ion binding]; other site
418136002449	putative homodimer-homodimer interface [polypeptide binding]; other site
418136002450	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
418136002451	aldehyde dehydrogenase family 7 member; Region: PLN02315
418136002452	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
418136002453	tetrameric interface [polypeptide binding]; other site
418136002454	NAD binding site [chemical binding]; other site
418136002455	catalytic residues [active]
418136002456	contains frameshift and premature stop
418136002457	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
418136002458	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
418136002459	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
418136002460	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
418136002461	active site
418136002462	catalytic site [active]
418136002463	substrate binding site [chemical binding]; other site
418136002464	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
418136002465	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
418136002466	PhnA protein; Region: PhnA; pfam03831
418136002467	contains frameshifts
418136002468	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
418136002469	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
418136002470	motif II; other site
418136002471	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
418136002472	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
418136002473	putative ATP binding site [chemical binding]; other site
418136002474	putative substrate interface [chemical binding]; other site
418136002475	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
418136002476	N-acetyl-D-glucosamine binding site [chemical binding]; other site
418136002477	catalytic residue [active]
418136002478	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
418136002479	diiron binding motif [ion binding]; other site
418136002480	malate dehydrogenase; Reviewed; Region: PRK06223
418136002481	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
418136002482	NAD(P) binding site [chemical binding]; other site
418136002483	dimer interface [polypeptide binding]; other site
418136002484	tetramer (dimer of dimers) interface [polypeptide binding]; other site
418136002485	substrate binding site [chemical binding]; other site
418136002486	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
418136002487	Class I ribonucleotide reductase; Region: RNR_I; cd01679
418136002488	active site
418136002489	dimer interface [polypeptide binding]; other site
418136002490	catalytic residues [active]
418136002491	effector binding site; other site
418136002492	R2 peptide binding site; other site
418136002493	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
418136002494	GSH binding site [chemical binding]; other site
418136002495	catalytic residues [active]
418136002496	bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759
418136002497	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
418136002498	GSH binding site [chemical binding]; other site
418136002499	catalytic residues [active]
418136002500	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
418136002501	dimer interface [polypeptide binding]; other site
418136002502	putative radical transfer pathway; other site
418136002503	diiron center [ion binding]; other site
418136002504	tyrosyl radical; other site
418136002505	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
418136002506	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
418136002507	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
418136002508	ABC transporter; Region: ABC_tran_2; pfam12848
418136002509	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
418136002510	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
418136002511	DJ-1 family protein; Region: not_thiJ; TIGR01383
418136002512	conserved cys residue [active]
418136002513	contains frameshift
418136002514	AAA domain; Region: AAA_21; pfam13304
418136002515	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
418136002516	ABC transporter signature motif; other site
418136002517	Walker B; other site
418136002518	D-loop; other site
418136002519	H-loop/switch region; other site
418136002520	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
418136002521	AAA domain; Region: AAA_21; pfam13304
418136002522	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
418136002523	Walker A/P-loop; other site
418136002524	Walker A/P-loop; other site
418136002525	ATP binding site [chemical binding]; other site
418136002526	ATP binding site [chemical binding]; other site
418136002527	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
418136002528	putative active site [active]
418136002529	contains frameshifts
418136002530	Methyltransferase domain; Region: Methyltransf_26; pfam13659
418136002531	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
418136002532	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
418136002533	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
418136002534	FMN binding site [chemical binding]; other site
418136002535	active site
418136002536	catalytic residues [active]
418136002537	substrate binding site [chemical binding]; other site
418136002538	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
418136002539	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
418136002540	S-adenosylmethionine binding site [chemical binding]; other site
418136002541	disruption due to premature stop
418136002542	contains frameshift
418136002543	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
418136002544	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
418136002545	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
418136002546	phosphate binding site [ion binding]; other site
418136002547	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136002548	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136002549	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136002550	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
418136002551	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
418136002552	active site
418136002553	HIGH motif; other site
418136002554	dimer interface [polypeptide binding]; other site
418136002555	KMSKS motif; other site
418136002556	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
418136002557	RNA binding surface [nucleotide binding]; other site
418136002558	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
418136002559	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
418136002560	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
418136002561	active site
418136002562	HslU subunit interaction site [polypeptide binding]; other site
418136002563	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
418136002564	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
418136002565	Walker A motif; other site
418136002566	ATP binding site [chemical binding]; other site
418136002567	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
418136002568	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
418136002569	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
418136002570	POT family; Region: PTR2; cl17359
418136002571	contains frameshifts
418136002572	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
418136002573	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
418136002574	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
418136002575	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
418136002576	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
418136002577	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
418136002578	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
418136002579	dimerization domain [polypeptide binding]; other site
418136002580	dimer interface [polypeptide binding]; other site
418136002581	catalytic residues [active]
418136002582	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
418136002583	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
418136002584	putative active site [active]
418136002585	catalytic residue [active]
418136002586	GTP-binding protein YchF; Reviewed; Region: PRK09601
418136002587	YchF GTPase; Region: YchF; cd01900
418136002588	G1 box; other site
418136002589	GTP/Mg2+ binding site [chemical binding]; other site
418136002590	Switch I region; other site
418136002591	G2 box; other site
418136002592	Switch II region; other site
418136002593	G3 box; other site
418136002594	G4 box; other site
418136002595	G5 box; other site
418136002596	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
418136002597	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
418136002598	Methyltransferase domain; Region: Methyltransf_31; pfam13847
418136002599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
418136002600	S-adenosylmethionine binding site [chemical binding]; other site
418136002601	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
418136002602	Domain of unknown function DUF21; Region: DUF21; pfam01595
418136002603	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
418136002604	Transporter associated domain; Region: CorC_HlyC; pfam03471
418136002605	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
418136002606	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
418136002607	5S rRNA interface [nucleotide binding]; other site
418136002608	CTC domain interface [polypeptide binding]; other site
418136002609	L16 interface [polypeptide binding]; other site
418136002610	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
418136002611	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
418136002612	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
418136002613	active site
418136002614	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
418136002615	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
418136002616	putative active site [active]
418136002617	Zn binding site [ion binding]; other site
418136002618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136002619	Major Facilitator Superfamily; Region: MFS_1; pfam07690
418136002620	putative substrate translocation pore; other site
418136002621	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136002622	Major Facilitator Superfamily; Region: MFS_1; pfam07690
418136002623	putative substrate translocation pore; other site
418136002624	Mechanosensitive ion channel; Region: MS_channel; pfam00924
418136002625	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
418136002626	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
418136002627	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
418136002628	Isochorismatase family; Region: Isochorismatase; pfam00857
418136002629	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
418136002630	catalytic triad [active]
418136002631	conserved cis-peptide bond; other site
418136002632	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
418136002633	active site
418136002634	DNA binding site [nucleotide binding]
418136002635	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
418136002636	intersubunit interface [polypeptide binding]; other site
418136002637	active site
418136002638	Zn2+ binding site [ion binding]; other site
418136002639	histidine decarboxylase; Provisional; Region: PRK02769
418136002640	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
418136002641	catalytic residue [active]
418136002642	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
418136002643	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
418136002644	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337
418136002645	RmuC family; Region: RmuC; pfam02646
418136002646	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
418136002647	RuvA N terminal domain; Region: RuvA_N; pfam01330
418136002648	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
418136002649	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136002650	Major Facilitator Superfamily; Region: MFS_1; pfam07690
418136002651	putative substrate translocation pore; other site
418136002652	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
418136002653	active site
418136002654	putative DNA-binding cleft [nucleotide binding]; other site
418136002655	dimer interface [polypeptide binding]; other site
418136002656	hypothetical protein; Validated; Region: PRK00110
418136002657	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
418136002658	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
418136002659	conserved cys residue [active]
418136002660	lipoyl synthase; Provisional; Region: PRK05481
418136002661	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
418136002662	FeS/SAM binding site; other site
418136002663	contains frameshift
418136002664	POT family; Region: PTR2; cl17359
418136002665	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
418136002666	glutaredoxin 2; Provisional; Region: PRK10387
418136002667	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
418136002668	C-terminal domain interface [polypeptide binding]; other site
418136002669	GSH binding site (G-site) [chemical binding]; other site
418136002670	catalytic residues [active]
418136002671	putative dimer interface [polypeptide binding]; other site
418136002672	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
418136002673	N-terminal domain interface [polypeptide binding]; other site
418136002674	ferredoxin; Provisional; Region: PRK08764
418136002675	Putative Fe-S cluster; Region: FeS; cl17515
418136002676	4Fe-4S binding domain; Region: Fer4; pfam00037
418136002677	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
418136002678	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
418136002679	minor groove reading motif; other site
418136002680	helix-hairpin-helix signature motif; other site
418136002681	substrate binding pocket [chemical binding]; other site
418136002682	active site
418136002683	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
418136002684	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
418136002685	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
418136002686	YccA-like proteins; Region: YccA_like; cd10433
418136002687	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
418136002688	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
418136002689	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
418136002690	ATP binding site [chemical binding]; other site
418136002691	putative Mg++ binding site [ion binding]; other site
418136002692	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
418136002693	nucleotide binding region [chemical binding]; other site
418136002694	ATP-binding site [chemical binding]; other site
418136002695	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
418136002696	ketol-acid reductoisomerase; Region: ilvC; TIGR00465
418136002697	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
418136002698	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
418136002699	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
418136002700	putative valine binding site [chemical binding]; other site
418136002701	dimer interface [polypeptide binding]; other site
418136002702	contains frameshift
418136002703	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
418136002704	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
418136002705	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
418136002706	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
418136002707	homodimer interface [polypeptide binding]; other site
418136002708	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136002709	catalytic residue [active]
418136002710	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
418136002711	G1 box; other site
418136002712	GTP/Mg2+ binding site [chemical binding]; other site
418136002713	Switch I region; other site
418136002714	G2 box; other site
418136002715	G3 box; other site
418136002716	Switch II region; other site
418136002717	G4 box; other site
418136002718	G5 box; other site
418136002719	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
418136002720	Low molecular weight phosphatase family; Region: LMWPc; cd00115
418136002721	active site
418136002722	FtsH protease regulator HflC; Provisional; Region: PRK11029
418136002723	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
418136002724	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
418136002725	HflK protein; Region: hflK; TIGR01933
418136002726	hypothetical protein; Provisional; Region: PRK07588
418136002727	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
418136002728	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
418136002729	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
418136002730	HflX GTPase family; Region: HflX; cd01878
418136002731	G1 box; other site
418136002732	GTP/Mg2+ binding site [chemical binding]; other site
418136002733	Switch I region; other site
418136002734	G2 box; other site
418136002735	G3 box; other site
418136002736	Switch II region; other site
418136002737	G4 box; other site
418136002738	G5 box; other site
418136002739	bacterial Hfq-like; Region: Hfq; cd01716
418136002740	hexamer interface [polypeptide binding]; other site
418136002741	Sm1 motif; other site
418136002742	RNA binding site [nucleotide binding]; other site
418136002743	Sm2 motif; other site
418136002744	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
418136002745	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
418136002746	SurA N-terminal domain; Region: SurA_N_3; cl07813
418136002747	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
418136002748	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
418136002749	IHF dimer interface [polypeptide binding]; other site
418136002750	IHF - DNA interface [nucleotide binding]; other site
418136002751	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
418136002752	Found in ATP-dependent protease La (LON); Region: LON; smart00464
418136002753	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
418136002754	Walker A motif; other site
418136002755	ATP binding site [chemical binding]; other site
418136002756	Walker B motif; other site
418136002757	arginine finger; other site
418136002758	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
418136002759	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
418136002760	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
418136002761	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
418136002762	Walker A motif; other site
418136002763	ATP binding site [chemical binding]; other site
418136002764	Walker B motif; other site
418136002765	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
418136002766	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
418136002767	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
418136002768	oligomer interface [polypeptide binding]; other site
418136002769	active site residues [active]
418136002770	trigger factor; Provisional; Region: tig; PRK01490
418136002771	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
418136002772	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
418136002773	thymidine kinase; Provisional; Region: PRK04296
418136002774	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
418136002775	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
418136002776	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
418136002777	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
418136002778	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
418136002779	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
418136002780	FeS/SAM binding site; other site
418136002781	TRAM domain; Region: TRAM; pfam01938
418136002782	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
418136002783	PhoH-like protein; Region: PhoH; pfam02562
418136002784	metal-binding heat shock protein; Provisional; Region: PRK00016
418136002785	FOG: CBS domain [General function prediction only]; Region: COG0517
418136002786	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
418136002787	Transporter associated domain; Region: CorC_HlyC; smart01091
418136002788	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
418136002789	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
418136002790	putative active site [active]
418136002791	catalytic triad [active]
418136002792	putative dimer interface [polypeptide binding]; other site
418136002793	VirK protein; Region: VirK; pfam06903
418136002794	beta-lactamase TEM; Provisional; Region: PRK15442
418136002795	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
418136002796	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
418136002797	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
418136002798	active site
418136002799	substrate binding site [chemical binding]; other site
418136002800	Mg2+ binding site [ion binding]; other site
418136002801	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
418136002802	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
418136002803	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
418136002804	active site
418136002805	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
418136002806	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
418136002807	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
418136002808	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
418136002809	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
418136002810	contains frameshifts
418136002811	contains frameshifts and premature stop
418136002812	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
418136002813	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
418136002814	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136002815	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
418136002816	putative substrate translocation pore; other site
418136002817	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136002818	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
418136002819	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
418136002820	dimer interface [polypeptide binding]; other site
418136002821	active site
418136002822	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
418136002823	dimer interface [polypeptide binding]; other site
418136002824	active site
418136002825	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
418136002826	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
418136002827	Uncharacterized conserved protein [Function unknown]; Region: COG0397
418136002828	hypothetical protein; Validated; Region: PRK00029
418136002829	Rubredoxin [Energy production and conversion]; Region: COG1773
418136002830	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
418136002831	iron binding site [ion binding]; other site
418136002832	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
418136002833	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
418136002834	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
418136002835	catalytic residue [active]
418136002836	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
418136002837	active site clefts [active]
418136002838	zinc binding site [ion binding]; other site
418136002839	dimer interface [polypeptide binding]; other site
418136002840	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
418136002841	active site
418136002842	homodimer interface [polypeptide binding]; other site
418136002843	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
418136002844	RNA/DNA hybrid binding site [nucleotide binding]; other site
418136002845	active site
418136002846	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
418136002847	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
418136002848	hinge; other site
418136002849	active site
418136002850	Every ISFtu2 ORF in this genome has a premature stop at the identical position resulting in disruption of the ISFtu2 sequence in compariosn to Schu4 ISFtu2 elements.
418136002851	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
418136002852	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
418136002853	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
418136002854	DNA binding residues [nucleotide binding]
418136002855	Src Homology 3 domain superfamily; Region: SH3; cl17036
418136002856	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
418136002857	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
418136002858	Protein export membrane protein; Region: SecD_SecF; pfam02355
418136002859	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
418136002860	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
418136002861	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
418136002862	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
418136002863	Isochorismatase family; Region: Isochorismatase; pfam00857
418136002864	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
418136002865	catalytic triad [active]
418136002866	conserved cis-peptide bond; other site
418136002867	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
418136002868	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
418136002869	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
418136002870	dimerization interface [polypeptide binding]; other site
418136002871	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
418136002872	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
418136002873	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676
418136002874	Protein of unknown function (DUF3281); Region: DUF3281; pfam11685
418136002875	Protein of unknown function (DUF3281); Region: DUF3281; pfam11685
418136002876	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
418136002877	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
418136002878	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
418136002879	Walker A/P-loop; other site
418136002880	ATP binding site [chemical binding]; other site
418136002881	Q-loop/lid; other site
418136002882	ABC transporter signature motif; other site
418136002883	Walker B; other site
418136002884	D-loop; other site
418136002885	H-loop/switch region; other site
418136002886	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
418136002887	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
418136002888	dimer interface [polypeptide binding]; other site
418136002889	conserved gate region; other site
418136002890	ABC-ATPase subunit interface; other site
418136002891	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
418136002892	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
418136002893	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
418136002894	aromatic amino acid transport protein; Region: araaP; TIGR00837
418136002895	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
418136002896	active site residue [active]
418136002897	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
418136002898	active site residue [active]
418136002899	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
418136002900	homotrimer interaction site [polypeptide binding]; other site
418136002901	zinc binding site [ion binding]; other site
418136002902	CDP-binding sites; other site
418136002903	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
418136002904	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
418136002905	cyanophycin synthetase; Provisional; Region: PRK14016
418136002906	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
418136002907	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
418136002908	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
418136002909	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
418136002910	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
418136002911	putative MPT binding site; other site
418136002912	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
418136002913	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
418136002914	active site
418136002915	catalytic site [active]
418136002916	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
418136002917	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
418136002918	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
418136002919	Walker A motif; other site
418136002920	ATP binding site [chemical binding]; other site
418136002921	Walker B motif; other site
418136002922	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
418136002923	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
418136002924	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
418136002925	contains frameshift
418136002926	Predicted membrane protein [Function unknown]; Region: COG1511
418136002927	ferrochelatase; Reviewed; Region: hemH; PRK00035
418136002928	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
418136002929	C-terminal domain interface [polypeptide binding]; other site
418136002930	active site
418136002931	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
418136002932	active site
418136002933	N-terminal domain interface [polypeptide binding]; other site
418136002934	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
418136002935	DNA photolyase; Region: DNA_photolyase; pfam00875
418136002936	disrupted due to transposon insertion
418136002937	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136002938	Homeodomain-like domain; Region: HTH_23; cl17451
418136002939	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136002940	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136002941	disruption due to transposon insertion
418136002942	contains frameshift
418136002943	cation transport regulator; Reviewed; Region: chaB; PRK09582
418136002944	contains frameshift
418136002945	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
418136002946	Flavoprotein; Region: Flavoprotein; pfam02441
418136002947	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
418136002948	benzoate transport; Region: 2A0115; TIGR00895
418136002949	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136002950	putative substrate translocation pore; other site
418136002951	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
418136002952	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
418136002953	Proline dehydrogenase; Region: Pro_dh; pfam01619
418136002954	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
418136002955	Glutamate binding site [chemical binding]; other site
418136002956	NAD binding site [chemical binding]; other site
418136002957	catalytic residues [active]
418136002958	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
418136002959	NAD(P) binding site [chemical binding]; other site
418136002960	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
418136002961	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
418136002962	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
418136002963	active site
418136002964	dimer interface [polypeptide binding]; other site
418136002965	metal binding site [ion binding]; metal-binding site
418136002966	shikimate kinase; Reviewed; Region: aroK; PRK00131
418136002967	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
418136002968	ADP binding site [chemical binding]; other site
418136002969	magnesium binding site [ion binding]; other site
418136002970	putative shikimate binding site; other site
418136002971	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
418136002972	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
418136002973	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
418136002974	Pilus assembly protein, PilP; Region: PilP; pfam04351
418136002975	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
418136002976	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
418136002977	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
418136002978	adenylate kinase; Reviewed; Region: adk; PRK00279
418136002979	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
418136002980	AMP-binding site [chemical binding]; other site
418136002981	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
418136002982	contains frameshifts and premature stops
418136002983	GTPase Era; Reviewed; Region: era; PRK00089
418136002984	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
418136002985	G1 box; other site
418136002986	GTP/Mg2+ binding site [chemical binding]; other site
418136002987	Switch I region; other site
418136002988	G2 box; other site
418136002989	Switch II region; other site
418136002990	G3 box; other site
418136002991	G4 box; other site
418136002992	G5 box; other site
418136002993	aspartate aminotransferase; Provisional; Region: PRK05764
418136002994	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
418136002995	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136002996	homodimer interface [polypeptide binding]; other site
418136002997	catalytic residue [active]
418136002998	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
418136002999	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
418136003000	putative active site [active]
418136003001	putative dimer interface [polypeptide binding]; other site
418136003002	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
418136003003	Glycoprotease family; Region: Peptidase_M22; pfam00814
418136003004	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
418136003005	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
418136003006	active site
418136003007	dimer interface [polypeptide binding]; other site
418136003008	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
418136003009	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
418136003010	GTP/Mg2+ binding site [chemical binding]; other site
418136003011	G4 box; other site
418136003012	G5 box; other site
418136003013	G1 box; other site
418136003014	Switch I region; other site
418136003015	G2 box; other site
418136003016	G3 box; other site
418136003017	Switch II region; other site
418136003018	HsdM N-terminal domain; Region: HsdM_N; pfam12161
418136003019	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
418136003020	Methyltransferase domain; Region: Methyltransf_26; pfam13659
418136003021	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
418136003022	DNA-binding site [nucleotide binding]; DNA binding site
418136003023	RNA-binding motif; other site
418136003024	contains frameshift and premature stop
418136003025	contains frameshift and premature stop
418136003026	contains frameshift
418136003027	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
418136003028	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
418136003029	G1 box; other site
418136003030	putative GEF interaction site [polypeptide binding]; other site
418136003031	GTP/Mg2+ binding site [chemical binding]; other site
418136003032	Switch I region; other site
418136003033	G2 box; other site
418136003034	G3 box; other site
418136003035	Switch II region; other site
418136003036	G4 box; other site
418136003037	G5 box; other site
418136003038	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
418136003039	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
418136003040	contains frameshift
418136003041	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
418136003042	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
418136003043	contains frameshift and premature stop
418136003044	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
418136003045	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
418136003046	hypothetical protein; Validated; Region: PRK01777
418136003047	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
418136003048	putative coenzyme Q binding site [chemical binding]; other site
418136003049	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
418136003050	SmpB-tmRNA interface; other site
418136003051	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
418136003052	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
418136003053	Ligand Binding Site [chemical binding]; other site
418136003054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136003055	metabolite-proton symporter; Region: 2A0106; TIGR00883
418136003056	putative substrate translocation pore; other site
418136003057	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
418136003058	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
418136003059	generic binding surface II; other site
418136003060	generic binding surface I; other site
418136003061	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
418136003062	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
418136003063	metal binding site [ion binding]; metal-binding site
418136003064	dimer interface [polypeptide binding]; other site
418136003065	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
418136003066	putative dimer interface [polypeptide binding]; other site
418136003067	putative active site [active]
418136003068	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
418136003069	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
418136003070	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
418136003071	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
418136003072	metabolite-proton symporter; Region: 2A0106; TIGR00883
418136003073	glutamate racemase; Provisional; Region: PRK00865
418136003074	Nuclease-related domain; Region: NERD; pfam08378
418136003075	excinuclease ABC subunit B; Provisional; Region: PRK05298
418136003076	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
418136003077	ATP binding site [chemical binding]; other site
418136003078	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
418136003079	nucleotide binding region [chemical binding]; other site
418136003080	ATP-binding site [chemical binding]; other site
418136003081	Ultra-violet resistance protein B; Region: UvrB; pfam12344
418136003082	UvrB/uvrC motif; Region: UVR; pfam02151
418136003083	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
418136003084	active site
418136003085	catalytic site [active]
418136003086	substrate binding site [chemical binding]; other site
418136003087	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
418136003088	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
418136003089	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
418136003090	NAD(P) binding site [chemical binding]; other site
418136003091	active site
418136003092	Transcriptional regulator [Transcription]; Region: LysR; COG0583
418136003093	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
418136003094	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
418136003095	putative effector binding pocket; other site
418136003096	dimerization interface [polypeptide binding]; other site
418136003097	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
418136003098	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
418136003099	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
418136003100	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
418136003101	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
418136003102	tetramer (dimer of dimers) interface [polypeptide binding]; other site
418136003103	active site
418136003104	dimer interface [polypeptide binding]; other site
418136003105	contains frameshifts
418136003106	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136003107	Homeodomain-like domain; Region: HTH_23; cl17451
418136003108	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136003109	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136003110	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
418136003111	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
418136003112	malate dehydrogenase; Provisional; Region: PRK13529
418136003113	Malic enzyme, N-terminal domain; Region: malic; pfam00390
418136003114	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
418136003115	NAD(P) binding pocket [chemical binding]; other site
418136003116	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
418136003117	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
418136003118	active site
418136003119	Riboflavin kinase; Region: Flavokinase; pfam01687
418136003120	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
418136003121	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
418136003122	active site
418136003123	HIGH motif; other site
418136003124	nucleotide binding site [chemical binding]; other site
418136003125	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
418136003126	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
418136003127	active site
418136003128	KMSKS motif; other site
418136003129	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
418136003130	tRNA binding surface [nucleotide binding]; other site
418136003131	anticodon binding site; other site
418136003132	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
418136003133	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
418136003134	FtsJ-like methyltransferase; Region: FtsJ; cl17430
418136003135	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
418136003136	HD domain; Region: HD_3; pfam13023
418136003137	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
418136003138	active site
418136003139	catalytic triad [active]
418136003140	oxyanion hole [active]
418136003141	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
418136003142	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
418136003143	catalytic triad [active]
418136003144	ParB-like nuclease domain; Region: ParB; smart00470
418136003145	KorB domain; Region: KorB; pfam08535
418136003146	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
418136003147	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
418136003148	P-loop; other site
418136003149	Magnesium ion binding site [ion binding]; other site
418136003150	DNA topoisomerase I; Validated; Region: PRK06599
418136003151	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
418136003152	active site
418136003153	interdomain interaction site; other site
418136003154	putative metal-binding site [ion binding]; other site
418136003155	nucleotide binding site [chemical binding]; other site
418136003156	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
418136003157	domain I; other site
418136003158	DNA binding groove [nucleotide binding]
418136003159	phosphate binding site [ion binding]; other site
418136003160	domain II; other site
418136003161	domain III; other site
418136003162	nucleotide binding site [chemical binding]; other site
418136003163	catalytic site [active]
418136003164	domain IV; other site
418136003165	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
418136003166	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
418136003167	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
418136003168	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
418136003169	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
418136003170	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
418136003171	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
418136003172	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
418136003173	active site
418136003174	Zn binding site [ion binding]; other site
418136003175	hypothetical protein; Provisional; Region: PRK14682
418136003176	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
418136003177	ATP-grasp domain; Region: ATP-grasp; pfam02222
418136003178	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
418136003179	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
418136003180	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
418136003181	active site
418136003182	substrate binding site [chemical binding]; other site
418136003183	cosubstrate binding site; other site
418136003184	catalytic site [active]
418136003185	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
418136003186	active site
418136003187	ATP binding site [chemical binding]; other site
418136003188	substrate binding site [chemical binding]; other site
418136003189	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
418136003190	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
418136003191	ATP-grasp domain; Region: ATP-grasp_4; cl17255
418136003192	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
418136003193	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
418136003194	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
418136003195	dimerization interface [polypeptide binding]; other site
418136003196	putative ATP binding site [chemical binding]; other site
418136003197	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180
418136003198	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
418136003199	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
418136003200	homodimer interface [polypeptide binding]; other site
418136003201	NADP binding site [chemical binding]; other site
418136003202	substrate binding site [chemical binding]; other site
418136003203	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
418136003204	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
418136003205	active site
418136003206	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
418136003207	Pilin (bacterial filament); Region: Pilin; pfam00114
418136003208	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
418136003209	contains frameshift
418136003210	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
418136003211	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
418136003212	Walker A/P-loop; other site
418136003213	ATP binding site [chemical binding]; other site
418136003214	Q-loop/lid; other site
418136003215	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
418136003216	ABC transporter signature motif; other site
418136003217	Walker B; other site
418136003218	D-loop; other site
418136003219	H-loop/switch region; other site
418136003220	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
418136003221	Cation efflux family; Region: Cation_efflux; pfam01545
418136003222	aspartate aminotransferase; Provisional; Region: PRK07568
418136003223	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
418136003224	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136003225	homodimer interface [polypeptide binding]; other site
418136003226	catalytic residue [active]
418136003227	contains frameshift
418136003228	Cupin domain; Region: Cupin_2; cl17218
418136003229	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
418136003230	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
418136003231	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
418136003232	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
418136003233	E-class dimer interface [polypeptide binding]; other site
418136003234	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
418136003235	P-class dimer interface [polypeptide binding]; other site
418136003236	active site
418136003237	Cu2+ binding site [ion binding]; other site
418136003238	Zn2+ binding site [ion binding]; other site
418136003239	methionine sulfoxide reductase B; Provisional; Region: PRK00222
418136003240	PQ loop repeat; Region: PQ-loop; pfam04193
418136003241	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
418136003242	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
418136003243	Tetramer interface [polypeptide binding]; other site
418136003244	active site
418136003245	FMN-binding site [chemical binding]; other site
418136003246	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
418136003247	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
418136003248	PilZ domain; Region: PilZ; pfam07238
418136003249	DNA repair protein RadA; Provisional; Region: PRK11823
418136003250	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
418136003251	Walker A motif/ATP binding site; other site
418136003252	ATP binding site [chemical binding]; other site
418136003253	Walker B motif; other site
418136003254	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
418136003255	Colicin V production protein; Region: Colicin_V; pfam02674
418136003256	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
418136003257	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
418136003258	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
418136003259	disruption due to premature stop
418136003260	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
418136003261	dimerization interface [polypeptide binding]; other site
418136003262	putative DNA binding site [nucleotide binding]; other site
418136003263	putative Zn2+ binding site [ion binding]; other site
418136003264	disruption due to transposon insertion
418136003265	Every ISFtu2 ORF in this genome has a premature stop at the identical position resulting in disruption of the ISFtu2 sequence in compariosn to Schu4 ISFtu2 elements.
418136003266	disruption due to transposon
418136003267	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
418136003268	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
418136003269	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
418136003270	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
418136003271	putative dimerization interface [polypeptide binding]; other site
418136003272	LemA family; Region: LemA; cl00742
418136003273	heat shock protein HtpX; Provisional; Region: PRK02870
418136003274	contains frameshift
418136003275	ribonuclease PH; Reviewed; Region: rph; PRK00173
418136003276	Ribonuclease PH; Region: RNase_PH_bact; cd11362
418136003277	hexamer interface [polypeptide binding]; other site
418136003278	active site
418136003279	Chorismate lyase; Region: Chor_lyase; cl01230
418136003280	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847
418136003281	UbiA prenyltransferase family; Region: UbiA; pfam01040
418136003282	Protein of unknown function, DUF393; Region: DUF393; pfam04134
418136003283	Protein of unknown function (DUF423); Region: DUF423; pfam04241
418136003284	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
418136003285	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
418136003286	transmembrane helices; other site
418136003287	contains frameshift
418136003288	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
418136003289	hypothetical protein; Provisional; Region: PRK10621
418136003290	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
418136003291	YheO-like PAS domain; Region: PAS_6; pfam08348
418136003292	HTH domain; Region: HTH_22; pfam13309
418136003293	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
418136003294	Sodium Bile acid symporter family; Region: SBF; cl17470
418136003295	contains frameshift
418136003296	DNA photolyase; Region: DNA_photolyase; pfam00875
418136003297	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
418136003298	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
418136003299	C factor cell-cell signaling protein; Provisional; Region: PRK09009
418136003300	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
418136003301	NADP binding site [chemical binding]; other site
418136003302	homodimer interface [polypeptide binding]; other site
418136003303	active site
418136003304	disruption due to premature stop
418136003305	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
418136003306	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
418136003307	ligand binding site [chemical binding]; other site
418136003308	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
418136003309	TolB amino-terminal domain; Region: TolB_N; pfam04052
418136003310	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
418136003311	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
418136003312	TolR protein; Region: tolR; TIGR02801
418136003313	TolQ protein; Region: tolQ; TIGR02796
418136003314	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
418136003315	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
418136003316	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
418136003317	homotrimer interaction site [polypeptide binding]; other site
418136003318	active site
418136003319	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
418136003320	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
418136003321	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
418136003322	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
418136003323	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
418136003324	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
418136003325	ligand binding site [chemical binding]; other site
418136003326	DNA protecting protein DprA; Region: dprA; TIGR00732
418136003327	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
418136003328	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
418136003329	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
418136003330	TrkA-C domain; Region: TrkA_C; pfam02080
418136003331	TrkA-C domain; Region: TrkA_C; pfam02080
418136003332	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
418136003333	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
418136003334	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
418136003335	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136003336	homodimer interface [polypeptide binding]; other site
418136003337	catalytic residue [active]
418136003338	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
418136003339	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
418136003340	ArsC family; Region: ArsC; pfam03960
418136003341	catalytic residue [active]
418136003342	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
418136003343	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
418136003344	nudix motif; other site
418136003345	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136003346	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136003347	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136003348	contains frameshift
418136003349	Abi-like protein; Region: Abi_2; cl01988
418136003350	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
418136003351	N-terminal truncated
418136003352	Antirestriction protein (ArdA); Region: ArdA; pfam07275
418136003353	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136003354	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136003355	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136003356	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
418136003357	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
418136003358	non-specific DNA binding site [nucleotide binding]; other site
418136003359	salt bridge; other site
418136003360	sequence-specific DNA binding site [nucleotide binding]; other site
418136003361	contains frameshift
418136003362	contains frameshift
418136003363	recombination associated protein; Reviewed; Region: rdgC; PRK00321
418136003364	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
418136003365	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
418136003366	active site residue [active]
418136003367	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
418136003368	S1 domain; Region: S1_2; pfam13509
418136003369	S1 domain; Region: S1_2; pfam13509
418136003370	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
418136003371	Part of AAA domain; Region: AAA_19; pfam13245
418136003372	AAA domain; Region: AAA_14; pfam13173
418136003373	Family description; Region: UvrD_C_2; pfam13538
418136003374	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
418136003375	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
418136003376	Isochorismatase family; Region: Isochorismatase; pfam00857
418136003377	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
418136003378	catalytic triad [active]
418136003379	conserved cis-peptide bond; other site
418136003380	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
418136003381	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
418136003382	Isochorismatase family; Region: Isochorismatase; pfam00857
418136003383	catalytic triad [active]
418136003384	conserved cis-peptide bond; other site
418136003385	transaldolase-like protein; Provisional; Region: PTZ00411
418136003386	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
418136003387	active site
418136003388	dimer interface [polypeptide binding]; other site
418136003389	catalytic residue [active]
418136003390	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
418136003391	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
418136003392	interface (dimer of trimers) [polypeptide binding]; other site
418136003393	Substrate-binding/catalytic site; other site
418136003394	Zn-binding sites [ion binding]; other site
418136003395	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
418136003396	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
418136003397	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
418136003398	motif 1; other site
418136003399	active site
418136003400	motif 2; other site
418136003401	motif 3; other site
418136003402	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
418136003403	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
418136003404	Part of AAA domain; Region: AAA_19; pfam13245
418136003405	Family description; Region: UvrD_C_2; pfam13538
418136003406	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
418136003407	contains frameshifts
418136003408	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
418136003409	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
418136003410	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
418136003411	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
418136003412	catalytic residues [active]
418136003413	contains frameshift
418136003414	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
418136003415	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
418136003416	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
418136003417	TspO/MBR family; Region: TspO_MBR; pfam03073
418136003418	contains frameshift
418136003419	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
418136003420	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
418136003421	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
418136003422	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
418136003423	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
418136003424	active site
418136003425	Every ISFtu2 ORF in this genome has a premature stop at the identical position resulting in disruption of the ISFtu2 sequence in compariosn to Schu4 ISFtu2 elements.
418136003426	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
418136003427	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
418136003428	contains frameshift
418136003429	CRISPR/Cas system-associated protein Cas9; Region: Csx12; cd09704
418136003430	CRISPR-associated protein Cas9/Csx12, subtype II-B/NMENI; Region: cas_csx12; TIGR03031
418136003431	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
418136003432	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
418136003433	ligand binding site [chemical binding]; other site
418136003434	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
418136003435	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
418136003436	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
418136003437	active site
418136003438	(T/H)XGH motif; other site
418136003439	probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406
418136003440	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
418136003441	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
418136003442	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
418136003443	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
418136003444	catalytic residue [active]
418136003445	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
418136003446	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
418136003447	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
418136003448	Protein of unknown function DUF45; Region: DUF45; pfam01863
418136003449	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
418136003450	Prephenate dehydratase; Region: PDT; pfam00800
418136003451	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
418136003452	putative L-Phe binding site [chemical binding]; other site
418136003453	contains frameshift
418136003454	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
418136003455	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
418136003456	active site
418136003457	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
418136003458	dimer interface [polypeptide binding]; other site
418136003459	substrate binding site [chemical binding]; other site
418136003460	catalytic residues [active]
418136003461	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
418136003462	POT family; Region: PTR2; cl17359
418136003463	GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080
418136003464	putative C-terminal domain interface [polypeptide binding]; other site
418136003465	putative GSH binding site [chemical binding]; other site
418136003466	putative dimer interface [polypeptide binding]; other site
418136003467	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
418136003468	dimer interface [polypeptide binding]; other site
418136003469	substrate binding pocket (H-site) [chemical binding]; other site
418136003470	C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193
418136003471	putative N-terminal domain interface [polypeptide binding]; other site
418136003472	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
418136003473	hypothetical protein; Provisional; Region: PRK14013
418136003474	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
418136003475	motif II; other site
418136003476	contains frameshift
418136003477	Every ISFtu2 ORF in this genome has a premature stop at the identical position resulting in disruption of the ISFtu2 sequence in compariosn to Schu4 ISFtu2 elements.
418136003478	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136003479	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136003480	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136003481	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
418136003482	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
418136003483	Walker A/P-loop; other site
418136003484	ATP binding site [chemical binding]; other site
418136003485	Q-loop/lid; other site
418136003486	ABC transporter signature motif; other site
418136003487	Walker B; other site
418136003488	D-loop; other site
418136003489	H-loop/switch region; other site
418136003490	TOBE domain; Region: TOBE_2; pfam08402
418136003491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
418136003492	dimer interface [polypeptide binding]; other site
418136003493	conserved gate region; other site
418136003494	putative PBP binding loops; other site
418136003495	ABC-ATPase subunit interface; other site
418136003496	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
418136003497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
418136003498	dimer interface [polypeptide binding]; other site
418136003499	conserved gate region; other site
418136003500	putative PBP binding loops; other site
418136003501	ABC-ATPase subunit interface; other site
418136003502	ISFtu2 fragment resulting from frameshift and premature stop
418136003503	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
418136003504	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136003505	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136003506	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136003507	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
418136003508	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
418136003509	GIY-YIG motif/motif A; other site
418136003510	active site
418136003511	catalytic site [active]
418136003512	putative DNA binding site [nucleotide binding]; other site
418136003513	metal binding site [ion binding]; metal-binding site
418136003514	UvrB/uvrC motif; Region: UVR; pfam02151
418136003515	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
418136003516	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
418136003517	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
418136003518	catalytic site [active]
418136003519	putative active site [active]
418136003520	putative substrate binding site [chemical binding]; other site
418136003521	HRDC domain; Region: HRDC; pfam00570
418136003522	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
418136003523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136003524	putative substrate translocation pore; other site
418136003525	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
418136003526	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
418136003527	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
418136003528	contains frameshift resulting in C-terminal truncation
418136003529	disruption due to premature stop
418136003530	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
418136003531	DEAD/DEAH box helicase; Region: DEAD; pfam00270
418136003532	ATP binding site [chemical binding]; other site
418136003533	putative Mg++ binding site [ion binding]; other site
418136003534	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
418136003535	SEC-C motif; Region: SEC-C; pfam02810
418136003536	contains frameshift
418136003537	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
418136003538	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136003539	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136003540	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136003541	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
418136003542	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
418136003543	Walker A motif; other site
418136003544	ATP binding site [chemical binding]; other site
418136003545	Walker B motif; other site
418136003546	arginine finger; other site
418136003547	Peptidase family M41; Region: Peptidase_M41; pfam01434
418136003548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136003549	putative transporter; Provisional; Region: PRK10504
418136003550	putative substrate translocation pore; other site
418136003551	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
418136003552	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
418136003553	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
418136003554	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
418136003555	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
418136003556	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
418136003557	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
418136003558	Type II transport protein GspH; Region: GspH; pfam12019
418136003559	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
418136003560	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
418136003561	active site
418136003562	dimer interface [polypeptide binding]; other site
418136003563	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
418136003564	dimer interface [polypeptide binding]; other site
418136003565	active site
418136003566	Thiamine pyrophosphokinase; Region: TPK; cd07995
418136003567	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
418136003568	active site
418136003569	dimerization interface [polypeptide binding]; other site
418136003570	thiamine binding site [chemical binding]; other site
418136003571	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
418136003572	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
418136003573	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
418136003574	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
418136003575	active site
418136003576	multifunctional aminopeptidase A; Provisional; Region: PRK00913
418136003577	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
418136003578	interface (dimer of trimers) [polypeptide binding]; other site
418136003579	Substrate-binding/catalytic site; other site
418136003580	Zn-binding sites [ion binding]; other site
418136003581	Predicted permeases [General function prediction only]; Region: COG0795
418136003582	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
418136003583	Predicted permeases [General function prediction only]; Region: COG0795
418136003584	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
418136003585	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
418136003586	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
418136003587	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
418136003588	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
418136003589	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
418136003590	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
418136003591	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
418136003592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
418136003593	Predicted membrane protein [Function unknown]; Region: COG2860
418136003594	UPF0126 domain; Region: UPF0126; pfam03458
418136003595	UPF0126 domain; Region: UPF0126; pfam03458
418136003596	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
418136003597	active site
418136003598	dinuclear metal binding site [ion binding]; other site
418136003599	dimerization interface [polypeptide binding]; other site
418136003600	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
418136003601	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
418136003602	active site
418136003603	catalytic motif [active]
418136003604	Zn binding site [ion binding]; other site
418136003605	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
418136003606	FAD binding domain; Region: FAD_binding_4; pfam01565
418136003607	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
418136003608	phosphoglyceromutase; Provisional; Region: PRK05434
418136003609	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
418136003610	seryl-tRNA synthetase; Provisional; Region: PRK05431
418136003611	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
418136003612	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
418136003613	dimer interface [polypeptide binding]; other site
418136003614	active site
418136003615	motif 1; other site
418136003616	motif 2; other site
418136003617	motif 3; other site
418136003618	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
418136003619	ROK family; Region: ROK; pfam00480
418136003620	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
418136003621	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
418136003622	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
418136003623	Walker A/P-loop; other site
418136003624	ATP binding site [chemical binding]; other site
418136003625	Q-loop/lid; other site
418136003626	ABC transporter signature motif; other site
418136003627	Walker B; other site
418136003628	D-loop; other site
418136003629	H-loop/switch region; other site
418136003630	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
418136003631	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
418136003632	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
418136003633	Walker A/P-loop; other site
418136003634	ATP binding site [chemical binding]; other site
418136003635	Q-loop/lid; other site
418136003636	ABC transporter signature motif; other site
418136003637	Walker B; other site
418136003638	D-loop; other site
418136003639	H-loop/switch region; other site
418136003640	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
418136003641	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
418136003642	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
418136003643	homotrimer interaction site [polypeptide binding]; other site
418136003644	putative active site [active]
418136003645	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
418136003646	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
418136003647	Sulfate transporter family; Region: Sulfate_transp; pfam00916
418136003648	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
418136003649	Every ISFtu2 ORF in this genome has a premature stop at the identical position resulting in disruption of the ISFtu2 sequence in compariosn to Schu4 ISFtu2 elements.
418136003650	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
418136003651	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
418136003652	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
418136003653	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
418136003654	Walker A/P-loop; other site
418136003655	ATP binding site [chemical binding]; other site
418136003656	Q-loop/lid; other site
418136003657	ABC transporter signature motif; other site
418136003658	Walker B; other site
418136003659	D-loop; other site
418136003660	H-loop/switch region; other site
418136003661	contains frameshift
418136003662	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
418136003663	Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567
418136003664	active site
418136003665	catalytic site [active]
418136003666	metal binding site [ion binding]; metal-binding site
418136003667	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
418136003668	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136003669	putative substrate translocation pore; other site
418136003670	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
418136003671	classical (c) SDRs; Region: SDR_c; cd05233
418136003672	NAD(P) binding site [chemical binding]; other site
418136003673	active site
418136003674	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136003675	Homeodomain-like domain; Region: HTH_23; cl17451
418136003676	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136003677	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136003678	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
418136003679	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
418136003680	heme binding site [chemical binding]; other site
418136003681	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
418136003682	dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232
418136003683	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
418136003684	Zn2+ binding site [ion binding]; other site
418136003685	Mg2+ binding site [ion binding]; other site
418136003686	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
418136003687	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136003688	metabolite-proton symporter; Region: 2A0106; TIGR00883
418136003689	putative substrate translocation pore; other site
418136003690	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
418136003691	putative substrate binding pocket [chemical binding]; other site
418136003692	trimer interface [polypeptide binding]; other site
418136003693	contains frameshift
418136003694	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
418136003695	active site
418136003696	contains frameshift
418136003697	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
418136003698	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
418136003699	substrate-cofactor binding pocket; other site
418136003700	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136003701	catalytic residue [active]
418136003702	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
418136003703	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
418136003704	NAD(P) binding site [chemical binding]; other site
418136003705	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
418136003706	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
418136003707	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
418136003708	substrate binding site; other site
418136003709	dimer interface; other site
418136003710	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
418136003711	Septum formation initiator; Region: DivIC; cl17659
418136003712	enolase; Provisional; Region: eno; PRK00077
418136003713	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
418136003714	dimer interface [polypeptide binding]; other site
418136003715	metal binding site [ion binding]; metal-binding site
418136003716	substrate binding pocket [chemical binding]; other site
418136003717	Major Facilitator Superfamily; Region: MFS_1; pfam07690
418136003718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136003719	putative substrate translocation pore; other site
418136003720	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
418136003721	contains frameshift
418136003722	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
418136003723	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
418136003724	nucleotide binding site [chemical binding]; other site
418136003725	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
418136003726	TRAM domain; Region: TRAM; pfam01938
418136003727	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
418136003728	S-adenosylmethionine binding site [chemical binding]; other site
418136003729	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
418136003730	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
418136003731	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
418136003732	ATP-binding site [chemical binding]; other site
418136003733	Sugar specificity; other site
418136003734	Pyrimidine base specificity; other site
418136003735	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
418136003736	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
418136003737	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
418136003738	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
418136003739	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
418136003740	oligomer interface [polypeptide binding]; other site
418136003741	RNA binding site [nucleotide binding]; other site
418136003742	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
418136003743	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
418136003744	RNase E interface [polypeptide binding]; other site
418136003745	trimer interface [polypeptide binding]; other site
418136003746	active site
418136003747	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
418136003748	putative nucleic acid binding region [nucleotide binding]; other site
418136003749	G-X-X-G motif; other site
418136003750	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
418136003751	RNA binding site [nucleotide binding]; other site
418136003752	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
418136003753	16S/18S rRNA binding site [nucleotide binding]; other site
418136003754	S13e-L30e interaction site [polypeptide binding]; other site
418136003755	25S rRNA binding site [nucleotide binding]; other site
418136003756	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
418136003757	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
418136003758	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
418136003759	Cell division protein FtsL; Region: FtsL; cl11433
418136003760	MraW methylase family; Region: Methyltransf_5; cl17771
418136003761	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
418136003762	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
418136003763	AMP-binding enzyme; Region: AMP-binding; pfam00501
418136003764	acyl-activating enzyme (AAE) consensus motif; other site
418136003765	putative AMP binding site [chemical binding]; other site
418136003766	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
418136003767	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
418136003768	DNA binding site [nucleotide binding]
418136003769	catalytic residue [active]
418136003770	H2TH interface [polypeptide binding]; other site
418136003771	putative catalytic residues [active]
418136003772	turnover-facilitating residue; other site
418136003773	intercalation triad [nucleotide binding]; other site
418136003774	8OG recognition residue [nucleotide binding]; other site
418136003775	putative reading head residues; other site
418136003776	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
418136003777	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
418136003778	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136003779	Homeodomain-like domain; Region: HTH_23; cl17451
418136003780	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136003781	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136003782	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
418136003783	predicted active site [active]
418136003784	catalytic triad [active]
418136003785	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
418136003786	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
418136003787	active site
418136003788	multimer interface [polypeptide binding]; other site
418136003789	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
418136003790	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
418136003791	ATP binding site [chemical binding]; other site
418136003792	Mg2+ binding site [ion binding]; other site
418136003793	G-X-G motif; other site
418136003794	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
418136003795	anchoring element; other site
418136003796	dimer interface [polypeptide binding]; other site
418136003797	ATP binding site [chemical binding]; other site
418136003798	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
418136003799	active site
418136003800	putative metal-binding site [ion binding]; other site
418136003801	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
418136003802	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
418136003803	putative active site pocket [active]
418136003804	dimerization interface [polypeptide binding]; other site
418136003805	putative catalytic residue [active]
418136003806	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
418136003807	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
418136003808	FMN binding site [chemical binding]; other site
418136003809	active site
418136003810	catalytic residues [active]
418136003811	substrate binding site [chemical binding]; other site
418136003812	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
418136003813	TIGR03546 family protein; Region: TIGR03546
418136003814	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
418136003815	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
418136003816	CoA-ligase; Region: Ligase_CoA; pfam00549
418136003817	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
418136003818	CoA binding domain; Region: CoA_binding; smart00881
418136003819	CoA-ligase; Region: Ligase_CoA; pfam00549
418136003820	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
418136003821	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
418136003822	disruption due to premature stop
418136003823	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
418136003824	contains frameshift
418136003825	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
418136003826	contains frameshift
418136003827	Transcriptional regulator [Transcription]; Region: LysR; COG0583
418136003828	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
418136003829	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
418136003830	putative effector binding pocket; other site
418136003831	dimerization interface [polypeptide binding]; other site
418136003832	phosphoglycolate phosphatase; Provisional; Region: PRK13222
418136003833	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
418136003834	motif II; other site
418136003835	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
418136003836	PLD-like domain; Region: PLDc_2; pfam13091
418136003837	putative active site [active]
418136003838	catalytic site [active]
418136003839	Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107
418136003840	PLD-like domain; Region: PLDc_2; pfam13091
418136003841	putative active site [active]
418136003842	putative catalytic site [active]
418136003843	thioredoxin reductase; Provisional; Region: PRK10262
418136003844	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
418136003845	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
418136003846	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136003847	Major Facilitator Superfamily; Region: MFS_1; pfam07690
418136003848	putative substrate translocation pore; other site
418136003849	contains frameshift
418136003850	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
418136003851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
418136003852	ATP binding site [chemical binding]; other site
418136003853	Mg2+ binding site [ion binding]; other site
418136003854	G-X-G motif; other site
418136003855	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
418136003856	ATP binding site [chemical binding]; other site
418136003857	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
418136003858	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
418136003859	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
418136003860	Predicted GTPases [General function prediction only]; Region: COG1162
418136003861	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
418136003862	RNA binding site [nucleotide binding]; other site
418136003863	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
418136003864	GTPase/Zn-binding domain interface [polypeptide binding]; other site
418136003865	GTP/Mg2+ binding site [chemical binding]; other site
418136003866	G4 box; other site
418136003867	G5 box; other site
418136003868	G1 box; other site
418136003869	Switch I region; other site
418136003870	G2 box; other site
418136003871	G3 box; other site
418136003872	Switch II region; other site
418136003873	Protein of unknown function (DUF3281); Region: DUF3281; pfam11685
418136003874	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
418136003875	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
418136003876	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
418136003877	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
418136003878	Domain of unknown function DUF20; Region: UPF0118; pfam01594
418136003879	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
418136003880	DHH family; Region: DHH; pfam01368
418136003881	DHHA1 domain; Region: DHHA1; pfam02272
418136003882	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
418136003883	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
418136003884	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
418136003885	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
418136003886	motif 1; other site
418136003887	dimer interface [polypeptide binding]; other site
418136003888	active site
418136003889	motif 2; other site
418136003890	motif 3; other site
418136003891	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
418136003892	Mechanosensitive ion channel; Region: MS_channel; pfam00924
418136003893	Helix-turn-helix domain; Region: HTH_25; pfam13413
418136003894	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
418136003895	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
418136003896	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
418136003897	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
418136003898	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
418136003899	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
418136003900	carboxyltransferase (CT) interaction site; other site
418136003901	biotinylation site [posttranslational modification]; other site
418136003902	Dehydroquinase class II; Region: DHquinase_II; pfam01220
418136003903	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
418136003904	trimer interface [polypeptide binding]; other site
418136003905	active site
418136003906	dimer interface [polypeptide binding]; other site
418136003907	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
418136003908	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
418136003909	active site
418136003910	metal binding site [ion binding]; metal-binding site
418136003911	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
418136003912	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
418136003913	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
418136003914	SurA N-terminal domain; Region: SurA_N; pfam09312
418136003915	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
418136003916	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
418136003917	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
418136003918	Organic solvent tolerance protein; Region: OstA_C; pfam04453
418136003919	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
418136003920	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
418136003921	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
418136003922	active site
418136003923	HIGH motif; other site
418136003924	nucleotide binding site [chemical binding]; other site
418136003925	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
418136003926	KMSK motif region; other site
418136003927	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
418136003928	tRNA binding surface [nucleotide binding]; other site
418136003929	anticodon binding site; other site
418136003930	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
418136003931	active site
418136003932	homotetramer interface [polypeptide binding]; other site
418136003933	homodimer interface [polypeptide binding]; other site
418136003934	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
418136003935	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
418136003936	dimer interface [polypeptide binding]; other site
418136003937	active site
418136003938	Schiff base residues; other site
418136003939	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
418136003940	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
418136003941	DNA polymerase III subunit delta'; Validated; Region: PRK07993
418136003942	DNA polymerase III subunit delta'; Validated; Region: PRK08485
418136003943	putative inner membrane peptidase; Provisional; Region: PRK11778
418136003944	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
418136003945	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
418136003946	tandem repeat interface [polypeptide binding]; other site
418136003947	oligomer interface [polypeptide binding]; other site
418136003948	active site residues [active]
418136003949	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
418136003950	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
418136003951	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
418136003952	dimer interface [polypeptide binding]; other site
418136003953	N-terminal domain interface [polypeptide binding]; other site
418136003954	DsrC like protein; Region: DsrC; pfam04358
418136003955	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
418136003956	oxidative damage protection protein; Provisional; Region: PRK05408
418136003957	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
418136003958	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
418136003959	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
418136003960	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
418136003961	Ligand binding site; other site
418136003962	Putative Catalytic site; other site
418136003963	DXD motif; other site
418136003964	Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712
418136003965	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
418136003966	putative active site [active]
418136003967	YdjC motif; other site
418136003968	Mg binding site [ion binding]; other site
418136003969	putative homodimer interface [polypeptide binding]; other site
418136003970	cell division protein FtsW; Region: ftsW; TIGR02614
418136003971	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
418136003972	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
418136003973	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
418136003974	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
418136003975	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
418136003976	Mg++ binding site [ion binding]; other site
418136003977	putative catalytic motif [active]
418136003978	putative substrate binding site [chemical binding]; other site
418136003979	phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344
418136003980	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
418136003981	active site
418136003982	metal-binding site [ion binding]
418136003983	nucleotide-binding site [chemical binding]; other site
418136003984	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
418136003985	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
418136003986	active site
418136003987	HIGH motif; other site
418136003988	nucleotide binding site [chemical binding]; other site
418136003989	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
418136003990	KMSKS motif; other site
418136003991	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
418136003992	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
418136003993	contains frameshift
418136003994	ABC transporter ATPase component; Reviewed; Region: PRK11147
418136003995	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
418136003996	Walker A/P-loop; other site
418136003997	ATP binding site [chemical binding]; other site
418136003998	Q-loop/lid; other site
418136003999	ABC transporter signature motif; other site
418136004000	Walker B; other site
418136004001	D-loop; other site
418136004002	H-loop/switch region; other site
418136004003	ABC transporter; Region: ABC_tran_2; pfam12848
418136004004	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
418136004005	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136004006	Major Facilitator Superfamily; Region: MFS_1; pfam07690
418136004007	putative substrate translocation pore; other site
418136004008	Predicted membrane protein [Function unknown]; Region: COG4129
418136004009	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
418136004010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136004011	putative substrate translocation pore; other site
418136004012	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
418136004013	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
418136004014	disruption due to transposon
418136004015	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004016	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004017	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136004018	disruption due to transposon insertion
418136004019	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
418136004020	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
418136004021	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
418136004022	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
418136004023	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
418136004024	active site
418136004025	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
418136004026	putative active site [active]
418136004027	putative metal binding site [ion binding]; other site
418136004028	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
418136004029	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
418136004030	putative active site; other site
418136004031	catalytic triad [active]
418136004032	putative dimer interface [polypeptide binding]; other site
418136004033	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
418136004034	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
418136004035	contains frameshift
418136004036	spermidine synthase; Provisional; Region: PRK00811
418136004037	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
418136004038	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
418136004039	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
418136004040	threonine synthase; Validated; Region: PRK09225
418136004041	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
418136004042	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
418136004043	catalytic residue [active]
418136004044	homoserine kinase; Provisional; Region: PRK01212
418136004045	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
418136004046	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
418136004047	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
418136004048	nucleotide binding site [chemical binding]; other site
418136004049	substrate binding site [chemical binding]; other site
418136004050	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
418136004051	dimer interface [polypeptide binding]; other site
418136004052	putative threonine allosteric regulatory site; other site
418136004053	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
418136004054	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
418136004055	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
418136004056	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
418136004057	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
418136004058	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
418136004059	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
418136004060	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
418136004061	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
418136004062	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
418136004063	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
418136004064	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
418136004065	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
418136004066	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
418136004067	dimer interface [polypeptide binding]; other site
418136004068	motif 1; other site
418136004069	active site
418136004070	motif 2; other site
418136004071	motif 3; other site
418136004072	4-alpha-glucanotransferase; Provisional; Region: PRK14508
418136004073	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
418136004074	homodimer interface [polypeptide binding]; other site
418136004075	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
418136004076	active site pocket [active]
418136004077	glycogen synthase; Provisional; Region: glgA; PRK00654
418136004078	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
418136004079	ADP-binding pocket [chemical binding]; other site
418136004080	homodimer interface [polypeptide binding]; other site
418136004081	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
418136004082	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
418136004083	ligand binding site; other site
418136004084	oligomer interface; other site
418136004085	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
418136004086	dimer interface [polypeptide binding]; other site
418136004087	N-terminal domain interface [polypeptide binding]; other site
418136004088	sulfate 1 binding site; other site
418136004089	phosphoglucomutase; Region: PLN02307
418136004090	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
418136004091	substrate binding site [chemical binding]; other site
418136004092	dimer interface [polypeptide binding]; other site
418136004093	active site
418136004094	metal binding site [ion binding]; metal-binding site
418136004095	glycogen branching enzyme; Provisional; Region: PRK12313
418136004096	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
418136004097	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
418136004098	active site
418136004099	catalytic site [active]
418136004100	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
418136004101	pullulanase, type I; Region: pulA_typeI; TIGR02104
418136004102	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
418136004103	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
418136004104	Ca binding site [ion binding]; other site
418136004105	active site
418136004106	catalytic site [active]
418136004107	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
418136004108	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
418136004109	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
418136004110	shikimate binding site; other site
418136004111	NAD(P) binding site [chemical binding]; other site
418136004112	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
418136004113	tetramer interface [polypeptide binding]; other site
418136004114	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136004115	catalytic residue [active]
418136004116	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
418136004117	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
418136004118	tetramer interface [polypeptide binding]; other site
418136004119	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136004120	catalytic residue [active]
418136004121	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
418136004122	lipoyl attachment site [posttranslational modification]; other site
418136004123	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
418136004124	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
418136004125	lysine decarboxylase LdcC; Provisional; Region: PRK15399
418136004126	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
418136004127	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
418136004128	homodimer interface [polypeptide binding]; other site
418136004129	pyridoxal 5'-phosphate binding site [chemical binding]; other site
418136004130	catalytic residue [active]
418136004131	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
418136004132	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
418136004133	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
418136004134	Walker A/P-loop; other site
418136004135	ATP binding site [chemical binding]; other site
418136004136	Q-loop/lid; other site
418136004137	ABC transporter signature motif; other site
418136004138	Walker B; other site
418136004139	D-loop; other site
418136004140	H-loop/switch region; other site
418136004141	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
418136004142	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
418136004143	FtsX-like permease family; Region: FtsX; pfam02687
418136004144	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
418136004145	active site
418136004146	catalytic residues [active]
418136004147	metal binding site [ion binding]; metal-binding site
418136004148	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
418136004149	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
418136004150	putative active site [active]
418136004151	putative PHP Thumb interface [polypeptide binding]; other site
418136004152	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
418136004153	generic binding surface II; other site
418136004154	generic binding surface I; other site
418136004155	Predicted membrane protein [Function unknown]; Region: COG4325
418136004156	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
418136004157	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
418136004158	N-acetyl-D-glucosamine binding site [chemical binding]; other site
418136004159	catalytic residue [active]
418136004160	BNR repeat-like domain; Region: BNR_2; pfam13088
418136004161	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
418136004162	Asp-box motif; other site
418136004163	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
418136004164	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
418136004165	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
418136004166	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
418136004167	CAP-like domain; other site
418136004168	active site
418136004169	primary dimer interface [polypeptide binding]; other site
418136004170	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
418136004171	PLD-like domain; Region: PLDc_2; pfam13091
418136004172	putative homodimer interface [polypeptide binding]; other site
418136004173	putative active site [active]
418136004174	catalytic site [active]
418136004175	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
418136004176	active site
418136004177	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
418136004178	metal binding site [ion binding]; metal-binding site
418136004179	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
418136004180	DNA-binding site [nucleotide binding]; DNA binding site
418136004181	RNA-binding motif; other site
418136004182	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
418136004183	contains frameshift
418136004184	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
418136004185	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
418136004186	glutaminase active site [active]
418136004187	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
418136004188	dimer interface [polypeptide binding]; other site
418136004189	active site
418136004190	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
418136004191	dimer interface [polypeptide binding]; other site
418136004192	active site
418136004193	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
418136004194	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
418136004195	Substrate binding site; other site
418136004196	Mg++ binding site; other site
418136004197	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
418136004198	active site
418136004199	substrate binding site [chemical binding]; other site
418136004200	CoA binding site [chemical binding]; other site
418136004201	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
418136004202	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168
418136004203	active site
418136004204	(T/H)XGH motif; other site
418136004205	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
418136004206	nudix motif; other site
418136004207	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
418136004208	Every ISFtu2 ORF in this genome has a premature stop at the identical position resulting in disruption of the ISFtu2 sequence in compariosn to Schu4 ISFtu2 elements.
418136004209	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004210	Homeodomain-like domain; Region: HTH_23; cl17451
418136004211	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004212	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136004213	SnoaL-like domain; Region: SnoaL_2; pfam12680
418136004214	contains frameshift
418136004215	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
418136004216	ferredoxin-NADP reductase; Provisional; Region: PRK10926
418136004217	FAD binding pocket [chemical binding]; other site
418136004218	FAD binding motif [chemical binding]; other site
418136004219	phosphate binding motif [ion binding]; other site
418136004220	beta-alpha-beta structure motif; other site
418136004221	NAD binding pocket [chemical binding]; other site
418136004222	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
418136004223	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
418136004224	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
418136004225	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
418136004226	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
418136004227	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
418136004228	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
418136004229	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
418136004230	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
418136004231	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
418136004232	active site
418136004233	multimer interface [polypeptide binding]; other site
418136004234	CTP synthetase; Validated; Region: pyrG; PRK05380
418136004235	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
418136004236	Catalytic site [active]
418136004237	active site
418136004238	UTP binding site [chemical binding]; other site
418136004239	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
418136004240	active site
418136004241	putative oxyanion hole; other site
418136004242	catalytic triad [active]
418136004243	contains frameshift
418136004244	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004245	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004246	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136004247	ISFtu2 fragment resulting from frameshift and premature stop
418136004248	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
418136004249	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004250	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004251	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136004252	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
418136004253	short chain dehydrogenase; Provisional; Region: PRK05993
418136004254	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
418136004255	NADP binding site [chemical binding]; other site
418136004256	active site
418136004257	steroid binding site; other site
418136004258	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
418136004259	HI0933-like protein; Region: HI0933_like; pfam03486
418136004260	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
418136004261	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004262	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004263	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136004264	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
418136004265	ISFtu2 fragment resulting from frameshift and premature stop
418136004266	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004267	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004268	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136004269	heat shock protein 90; Provisional; Region: PRK05218
418136004270	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
418136004271	ATP binding site [chemical binding]; other site
418136004272	Mg2+ binding site [ion binding]; other site
418136004273	G-X-G motif; other site
418136004274	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004275	Homeodomain-like domain; Region: HTH_23; cl17451
418136004276	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004277	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136004278	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
418136004279	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
418136004280	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
418136004281	alphaNTD homodimer interface [polypeptide binding]; other site
418136004282	alphaNTD - beta interaction site [polypeptide binding]; other site
418136004283	alphaNTD - beta' interaction site [polypeptide binding]; other site
418136004284	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
418136004285	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
418136004286	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
418136004287	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
418136004288	RNA binding surface [nucleotide binding]; other site
418136004289	30S ribosomal protein S11; Validated; Region: PRK05309
418136004290	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
418136004291	30S ribosomal protein S13; Region: bact_S13; TIGR03631
418136004292	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
418136004293	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
418136004294	SecY translocase; Region: SecY; pfam00344
418136004295	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
418136004296	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
418136004297	23S rRNA binding site [nucleotide binding]; other site
418136004298	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
418136004299	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
418136004300	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
418136004301	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
418136004302	23S rRNA interface [nucleotide binding]; other site
418136004303	L21e interface [polypeptide binding]; other site
418136004304	5S rRNA interface [nucleotide binding]; other site
418136004305	L27 interface [polypeptide binding]; other site
418136004306	L5 interface [polypeptide binding]; other site
418136004307	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
418136004308	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
418136004309	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
418136004310	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
418136004311	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
418136004312	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
418136004313	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
418136004314	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
418136004315	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
418136004316	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
418136004317	RNA binding site [nucleotide binding]; other site
418136004318	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
418136004319	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
418136004320	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
418136004321	23S rRNA interface [nucleotide binding]; other site
418136004322	putative translocon interaction site; other site
418136004323	signal recognition particle (SRP54) interaction site; other site
418136004324	L23 interface [polypeptide binding]; other site
418136004325	trigger factor interaction site; other site
418136004326	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
418136004327	23S rRNA interface [nucleotide binding]; other site
418136004328	5S rRNA interface [nucleotide binding]; other site
418136004329	putative antibiotic binding site [chemical binding]; other site
418136004330	L25 interface [polypeptide binding]; other site
418136004331	L27 interface [polypeptide binding]; other site
418136004332	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
418136004333	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
418136004334	G-X-X-G motif; other site
418136004335	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
418136004336	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
418136004337	putative translocon binding site; other site
418136004338	protein-rRNA interface [nucleotide binding]; other site
418136004339	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
418136004340	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
418136004341	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
418136004342	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
418136004343	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
418136004344	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
418136004345	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
418136004346	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
418136004347	elongation factor G; Reviewed; Region: PRK00007
418136004348	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
418136004349	G1 box; other site
418136004350	putative GEF interaction site [polypeptide binding]; other site
418136004351	GTP/Mg2+ binding site [chemical binding]; other site
418136004352	Switch I region; other site
418136004353	G2 box; other site
418136004354	G3 box; other site
418136004355	Switch II region; other site
418136004356	G4 box; other site
418136004357	G5 box; other site
418136004358	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
418136004359	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
418136004360	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
418136004361	30S ribosomal protein S7; Validated; Region: PRK05302
418136004362	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
418136004363	S17 interaction site [polypeptide binding]; other site
418136004364	S8 interaction site; other site
418136004365	16S rRNA interaction site [nucleotide binding]; other site
418136004366	streptomycin interaction site [chemical binding]; other site
418136004367	23S rRNA interaction site [nucleotide binding]; other site
418136004368	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
418136004369	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
418136004370	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
418136004371	trimer interface [polypeptide binding]; other site
418136004372	active site
418136004373	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
418136004374	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
418136004375	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836
418136004376	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
418136004377	catalytic residue [active]
418136004378	putative FPP diphosphate  binding site; other site
418136004379	putative FPP binding hydrophobic cleft; other site
418136004380	dimer interface [polypeptide binding]; other site
418136004381	putative IPP diphosphate binding site; other site
418136004382	ribosome recycling factor; Reviewed; Region: frr; PRK00083
418136004383	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
418136004384	hinge region; other site
418136004385	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
418136004386	putative nucleotide binding site [chemical binding]; other site
418136004387	uridine monophosphate binding site [chemical binding]; other site
418136004388	homohexameric interface [polypeptide binding]; other site
418136004389	elongation factor Ts; Provisional; Region: tsf; PRK09377
418136004390	UBA/TS-N domain; Region: UBA; pfam00627
418136004391	Elongation factor TS; Region: EF_TS; pfam00889
418136004392	Elongation factor TS; Region: EF_TS; pfam00889
418136004393	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
418136004394	rRNA interaction site [nucleotide binding]; other site
418136004395	S8 interaction site; other site
418136004396	putative laminin-1 binding site; other site
418136004397	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
418136004398	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
418136004399	folate binding site [chemical binding]; other site
418136004400	NADP+ binding site [chemical binding]; other site
418136004401	contains frameshift
418136004402	contains frameshift
418136004403	Every ISFtu2 ORF in this genome has a premature stop at the identical position resulting in disruption of the ISFtu2 sequence in compariosn to Schu4 ISFtu2 elements.
418136004404	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
418136004405	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
418136004406	HIGH motif; other site
418136004407	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
418136004408	active site
418136004409	KMSKS motif; other site
418136004410	fumarate hydratase; Reviewed; Region: fumC; PRK00485
418136004411	Class II fumarases; Region: Fumarase_classII; cd01362
418136004412	active site
418136004413	tetramer interface [polypeptide binding]; other site
418136004414	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
418136004415	nudix motif; other site
418136004416	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
418136004417	dimer interface [polypeptide binding]; other site
418136004418	FMN binding site [chemical binding]; other site
418136004419	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
418136004420	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
418136004421	phosphate binding site [ion binding]; other site
418136004422	1-deoxy-D-xylulose-5-phosphate synthase; Region: PLN02225
418136004423	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
418136004424	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
418136004425	HIGH motif; other site
418136004426	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
418136004427	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
418136004428	active site
418136004429	KMSKS motif; other site
418136004430	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
418136004431	tRNA binding surface [nucleotide binding]; other site
418136004432	anticodon binding site; other site
418136004433	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
418136004434	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
418136004435	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
418136004436	putative substrate binding pocket [chemical binding]; other site
418136004437	AC domain interface; other site
418136004438	catalytic triad [active]
418136004439	AB domain interface; other site
418136004440	interchain disulfide; other site
418136004441	Oxygen tolerance; Region: BatD; pfam13584
418136004442	contains frameshift
418136004443	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
418136004444	metal ion-dependent adhesion site (MIDAS); other site
418136004445	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
418136004446	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
418136004447	Protein of unknown function DUF58; Region: DUF58; pfam01882
418136004448	MoxR-like ATPases [General function prediction only]; Region: COG0714
418136004449	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
418136004450	Walker A motif; other site
418136004451	ATP binding site [chemical binding]; other site
418136004452	Walker B motif; other site
418136004453	arginine finger; other site
418136004454	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
418136004455	pyridoxamine kinase; Validated; Region: PRK05756
418136004456	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
418136004457	dimer interface [polypeptide binding]; other site
418136004458	pyridoxal binding site [chemical binding]; other site
418136004459	ATP binding site [chemical binding]; other site
418136004460	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244
418136004461	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
418136004462	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
418136004463	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
418136004464	trimer interface [polypeptide binding]; other site
418136004465	active site
418136004466	UDP-GlcNAc binding site [chemical binding]; other site
418136004467	lipid binding site [chemical binding]; lipid-binding site
418136004468	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
418136004469	UbiA prenyltransferase family; Region: UbiA; pfam01040
418136004470	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
418136004471	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
418136004472	Subunit I/III interface [polypeptide binding]; other site
418136004473	Subunit III/IV interface [polypeptide binding]; other site
418136004474	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
418136004475	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
418136004476	D-pathway; other site
418136004477	Putative ubiquinol binding site [chemical binding]; other site
418136004478	Low-spin heme (heme b) binding site [chemical binding]; other site
418136004479	Putative water exit pathway; other site
418136004480	Binuclear center (heme o3/CuB) [ion binding]; other site
418136004481	K-pathway; other site
418136004482	Putative proton exit pathway; other site
418136004483	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
418136004484	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
418136004485	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
418136004486	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136004487	Major Facilitator Superfamily; Region: MFS_1; pfam07690
418136004488	putative substrate translocation pore; other site
418136004489	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
418136004490	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
418136004491	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
418136004492	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
418136004493	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
418136004494	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
418136004495	substrate binding pocket [chemical binding]; other site
418136004496	membrane-bound complex binding site; other site
418136004497	hinge residues; other site
418136004498	contains frameshift
418136004499	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004500	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004501	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136004502	Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672
418136004503	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
418136004504	RNB domain; Region: RNB; pfam00773
418136004505	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
418136004506	putative hydrolase; Provisional; Region: PRK11460
418136004507	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
418136004508	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
418136004509	domain interfaces; other site
418136004510	active site
418136004511	camphor resistance protein CrcB; Provisional; Region: PRK14226
418136004512	contains frameshift
418136004513	Zinc-finger domain; Region: zf-CHCC; cl01821
418136004514	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
418136004515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
418136004516	dimer interface [polypeptide binding]; other site
418136004517	conserved gate region; other site
418136004518	putative PBP binding loops; other site
418136004519	ABC-ATPase subunit interface; other site
418136004520	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
418136004521	dimer interface [polypeptide binding]; other site
418136004522	conserved gate region; other site
418136004523	putative PBP binding loops; other site
418136004524	ABC-ATPase subunit interface; other site
418136004525	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
418136004526	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
418136004527	Walker A/P-loop; other site
418136004528	ATP binding site [chemical binding]; other site
418136004529	Q-loop/lid; other site
418136004530	ABC transporter signature motif; other site
418136004531	Walker B; other site
418136004532	D-loop; other site
418136004533	H-loop/switch region; other site
418136004534	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
418136004535	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
418136004536	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
418136004537	TrkA-N domain; Region: TrkA_N; pfam02254
418136004538	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
418136004539	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
418136004540	trimer interface [polypeptide binding]; other site
418136004541	putative metal binding site [ion binding]; other site
418136004542	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
418136004543	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
418136004544	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
418136004545	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
418136004546	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004547	Homeodomain-like domain; Region: HTH_23; cl17451
418136004548	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004549	disruption due to transposon insertion
418136004550	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
418136004551	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
418136004552	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
418136004553	Phosphoesterase family; Region: Phosphoesterase; pfam04185
418136004554	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
418136004555	uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801
418136004556	putative active site [active]
418136004557	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
418136004558	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
418136004559	disruption due to transposon insertion
418136004560	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004561	Homeodomain-like domain; Region: HTH_23; cl17451
418136004562	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004563	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136004564	disruption due to transposon insertion
418136004565	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
418136004566	Ligand Binding Site [chemical binding]; other site
418136004567	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
418136004568	Ligand Binding Site [chemical binding]; other site
418136004569	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
418136004570	PLD-like domain; Region: PLDc_2; pfam13091
418136004571	putative homodimer interface [polypeptide binding]; other site
418136004572	putative active site [active]
418136004573	catalytic site [active]
418136004574	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
418136004575	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
418136004576	ATP binding site [chemical binding]; other site
418136004577	putative Mg++ binding site [ion binding]; other site
418136004578	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
418136004579	nucleotide binding region [chemical binding]; other site
418136004580	ATP-binding site [chemical binding]; other site
418136004581	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
418136004582	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
418136004583	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
418136004584	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
418136004585	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
418136004586	Mitochondrial PGP phosphatase; Region: PGP_phosphatase; pfam09419
418136004587	Predicted methyltransferases [General function prediction only]; Region: COG0313
418136004588	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
418136004589	putative SAM binding site [chemical binding]; other site
418136004590	putative homodimer interface [polypeptide binding]; other site
418136004591	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
418136004592	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
418136004593	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
418136004594	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
418136004595	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
418136004596	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
418136004597	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
418136004598	shikimate binding site; other site
418136004599	NAD(P) binding site [chemical binding]; other site
418136004600	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
418136004601	membrane protein insertase; Provisional; Region: PRK01318
418136004602	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
418136004603	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
418136004604	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
418136004605	putative acyl-acceptor binding pocket; other site
418136004606	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
418136004607	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
418136004608	putative acyl-acceptor binding pocket; other site
418136004609	elongation factor P; Validated; Region: PRK00529
418136004610	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
418136004611	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
418136004612	RNA binding site [nucleotide binding]; other site
418136004613	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
418136004614	RNA binding site [nucleotide binding]; other site
418136004615	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
418136004616	catalytic site [active]
418136004617	putative active site [active]
418136004618	putative substrate binding site [chemical binding]; other site
418136004619	dimer interface [polypeptide binding]; other site
418136004620	disruption due to transposon
418136004621	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004622	Homeodomain-like domain; Region: HTH_23; cl17451
418136004623	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004624	disruption due to transpsoson
418136004625	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
418136004626	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
418136004627	G1 box; other site
418136004628	GTP/Mg2+ binding site [chemical binding]; other site
418136004629	Switch I region; other site
418136004630	G2 box; other site
418136004631	G3 box; other site
418136004632	Switch II region; other site
418136004633	G4 box; other site
418136004634	G5 box; other site
418136004635	Nucleoside recognition; Region: Gate; pfam07670
418136004636	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
418136004637	Nucleoside recognition; Region: Gate; pfam07670
418136004638	pyruvate phosphate dikinase; Provisional; Region: PRK09279
418136004639	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
418136004640	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
418136004641	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
418136004642	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
418136004643	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
418136004644	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
418136004645	homodimer interface [polypeptide binding]; other site
418136004646	substrate-cofactor binding pocket; other site
418136004647	catalytic residue [active]
418136004648	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
418136004649	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
418136004650	active site
418136004651	catalytic residues [active]
418136004652	metal binding site [ion binding]; metal-binding site
418136004653	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004654	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004655	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136004656	primosome assembly protein PriA; Validated; Region: PRK05580
418136004657	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
418136004658	ATP binding site [chemical binding]; other site
418136004659	putative Mg++ binding site [ion binding]; other site
418136004660	helicase superfamily c-terminal domain; Region: HELICc; smart00490
418136004661	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
418136004662	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
418136004663	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
418136004664	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
418136004665	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
418136004666	contains frameshift
418136004667	contains frameshift
418136004668	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
418136004669	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
418136004670	intersubunit interface [polypeptide binding]; other site
418136004671	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
418136004672	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
418136004673	Walker A/P-loop; other site
418136004674	ATP binding site [chemical binding]; other site
418136004675	Q-loop/lid; other site
418136004676	ABC transporter signature motif; other site
418136004677	Walker B; other site
418136004678	D-loop; other site
418136004679	H-loop/switch region; other site
418136004680	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
418136004681	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
418136004682	dimer interface [polypeptide binding]; other site
418136004683	putative PBP binding regions; other site
418136004684	ABC-ATPase subunit  interface; other site
418136004685	Dienelactone hydrolase family; Region: DLH; pfam01738
418136004686	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
418136004687	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
418136004688	active site
418136004689	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
418136004690	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
418136004691	GDP-binding site [chemical binding]; other site
418136004692	ACT binding site; other site
418136004693	IMP binding site; other site
418136004694	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
418136004695	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
418136004696	purine monophosphate binding site [chemical binding]; other site
418136004697	dimer interface [polypeptide binding]; other site
418136004698	putative catalytic residues [active]
418136004699	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
418136004700	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
418136004701	disruption due to transposon insertion and multiple frameshifts
418136004702	Every ISFtu2 ORF in this genome has a premature stop at the identical position resulting in disruption of the ISFtu2 sequence in compariosn to Schu4 ISFtu2 elements.
418136004703	disruption due to transposons
418136004704	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
418136004705	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
418136004706	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
418136004707	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
418136004708	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
418136004709	glutamine synthetase; Region: PLN02284
418136004710	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
418136004711	Eps15 homology domain; Region: EH; smart00027
418136004712	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
418136004713	Glutaminase; Region: Glutaminase; cl00907
418136004714	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
418136004715	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
418136004716	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
418136004717	CAAX protease self-immunity; Region: Abi; pfam02517
418136004718	hypothetical protein; Provisional; Region: PRK05208
418136004719	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
418136004720	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
418136004721	dimer interface [polypeptide binding]; other site
418136004722	putative anticodon binding site; other site
418136004723	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
418136004724	motif 1; other site
418136004725	active site
418136004726	motif 2; other site
418136004727	motif 3; other site
418136004728	This domain is found in peptide chain release factors; Region: PCRF; smart00937
418136004729	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
418136004730	RF-1 domain; Region: RF-1; pfam00472
418136004731	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957
418136004732	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
418136004733	Walker A motif; other site
418136004734	ATP binding site [chemical binding]; other site
418136004735	Walker B motif; other site
418136004736	DNA polymerase III subunit delta'; Validated; Region: PRK08485
418136004737	arginine finger; other site
418136004738	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
418136004739	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
418136004740	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
418136004741	cell division protein FtsZ; Validated; Region: PRK09330
418136004742	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
418136004743	nucleotide binding site [chemical binding]; other site
418136004744	SulA interaction site; other site
418136004745	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
418136004746	Cell division protein FtsA; Region: FtsA; smart00842
418136004747	Cell division protein FtsA; Region: FtsA; pfam14450
418136004748	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
418136004749	Cell division protein FtsQ; Region: FtsQ; pfam03799
418136004750	D-alanyl-alanine synthetase A; Provisional; Region: PRK14569
418136004751	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
418136004752	ATP-grasp domain; Region: ATP-grasp_4; cl17255
418136004753	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
418136004754	nucleoside/Zn binding site; other site
418136004755	dimer interface [polypeptide binding]; other site
418136004756	catalytic motif [active]
418136004757	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
418136004758	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
418136004759	RNA binding site [nucleotide binding]; other site
418136004760	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
418136004761	RNA binding site [nucleotide binding]; other site
418136004762	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
418136004763	RNA binding site [nucleotide binding]; other site
418136004764	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
418136004765	RNA binding site [nucleotide binding]; other site
418136004766	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
418136004767	RNA binding site [nucleotide binding]; other site
418136004768	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
418136004769	RNA binding site [nucleotide binding]; other site
418136004770	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
418136004771	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
418136004772	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
418136004773	putative acyl-acceptor binding pocket; other site
418136004774	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
418136004775	Competence protein; Region: Competence; pfam03772
418136004776	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
418136004777	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
418136004778	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
418136004779	ATP-grasp domain; Region: ATP-grasp_4; cl17255
418136004780	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
418136004781	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
418136004782	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
418136004783	Coenzyme A binding pocket [chemical binding]; other site
418136004784	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
418136004785	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
418136004786	dimer interface [polypeptide binding]; other site
418136004787	conserved gate region; other site
418136004788	putative PBP binding loops; other site
418136004789	ABC-ATPase subunit interface; other site
418136004790	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
418136004791	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
418136004792	Walker A/P-loop; other site
418136004793	ATP binding site [chemical binding]; other site
418136004794	Q-loop/lid; other site
418136004795	ABC transporter signature motif; other site
418136004796	Walker B; other site
418136004797	D-loop; other site
418136004798	H-loop/switch region; other site
418136004799	YGGT family; Region: YGGT; pfam02325
418136004800	YGGT family; Region: YGGT; pfam02325
418136004801	disrupted ORF
418136004802	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004803	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004804	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136004805	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
418136004806	putative FMN binding site [chemical binding]; other site
418136004807	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
418136004808	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
418136004809	aromatic amino acid transport protein; Region: araaP; TIGR00837
418136004810	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
418136004811	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
418136004812	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
418136004813	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
418136004814	catalytic residue [active]
418136004815	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
418136004816	Transcriptional regulator [Transcription]; Region: LysR; COG0583
418136004817	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
418136004818	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
418136004819	putative effector binding pocket; other site
418136004820	dimerization interface [polypeptide binding]; other site
418136004821	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136004822	putative substrate translocation pore; other site
418136004823	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
418136004824	contains frameshifts and premature stop
418136004825	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
418136004826	dimer interface [polypeptide binding]; other site
418136004827	active site
418136004828	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
418136004829	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
418136004830	GTP-binding protein LepA; Provisional; Region: PRK05433
418136004831	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
418136004832	G1 box; other site
418136004833	putative GEF interaction site [polypeptide binding]; other site
418136004834	GTP/Mg2+ binding site [chemical binding]; other site
418136004835	Switch I region; other site
418136004836	G2 box; other site
418136004837	G3 box; other site
418136004838	Switch II region; other site
418136004839	G4 box; other site
418136004840	G5 box; other site
418136004841	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
418136004842	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
418136004843	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
418136004844	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
418136004845	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
418136004846	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
418136004847	active site
418136004848	catalytic residues [active]
418136004849	metal binding site [ion binding]; metal-binding site
418136004850	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
418136004851	homopentamer interface [polypeptide binding]; other site
418136004852	active site
418136004853	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
418136004854	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
418136004855	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
418136004856	dimerization interface [polypeptide binding]; other site
418136004857	active site
418136004858	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
418136004859	Lumazine binding domain; Region: Lum_binding; pfam00677
418136004860	Lumazine binding domain; Region: Lum_binding; pfam00677
418136004861	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
418136004862	catalytic motif [active]
418136004863	Zn binding site [ion binding]; other site
418136004864	RibD C-terminal domain; Region: RibD_C; pfam01872
418136004865	disruption due to transposon insertion
418136004866	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004867	Homeodomain-like domain; Region: HTH_23; cl17451
418136004868	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004869	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136004870	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
418136004871	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
418136004872	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
418136004873	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
418136004874	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
418136004875	NAD binding site [chemical binding]; other site
418136004876	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
418136004877	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
418136004878	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
418136004879	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
418136004880	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
418136004881	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
418136004882	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
418136004883	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
418136004884	ATP-grasp domain; Region: ATP-grasp_4; cl17255
418136004885	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
418136004886	substrate binding site [chemical binding]; other site
418136004887	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
418136004888	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
418136004889	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
418136004890	catalytic site [active]
418136004891	subunit interface [polypeptide binding]; other site
418136004892	disruption due to premature stop
418136004893	thiopurine S-methyltransferase; Reviewed; Region: PRK13256
418136004894	dihydroorotase; Reviewed; Region: PRK09236
418136004895	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
418136004896	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
418136004897	active site
418136004898	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
418136004899	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
418136004900	HlyD family secretion protein; Region: HlyD; pfam00529
418136004901	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
418136004902	HlyD family secretion protein; Region: HlyD_3; pfam13437
418136004903	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
418136004904	Transcriptional regulator [Transcription]; Region: LysR; COG0583
418136004905	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
418136004906	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
418136004907	dimerization interface [polypeptide binding]; other site
418136004908	SOUL heme-binding protein; Region: SOUL; pfam04832
418136004909	Chorismate mutase type II; Region: CM_2; smart00830
418136004910	contains frameshift
418136004911	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
418136004912	active site
418136004913	dimer interface [polypeptide binding]; other site
418136004914	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
418136004915	phosphate binding site [ion binding]; other site
418136004916	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
418136004917	putative active site [active]
418136004918	dimerization interface [polypeptide binding]; other site
418136004919	putative tRNAtyr binding site [nucleotide binding]; other site
418136004920	Major Facilitator Superfamily; Region: MFS_1; pfam07690
418136004921	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136004922	putative substrate translocation pore; other site
418136004923	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
418136004924	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
418136004925	substrate binding [chemical binding]; other site
418136004926	active site
418136004927	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
418136004928	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004929	Homeodomain-like domain; Region: HTH_23; cl17451
418136004930	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004931	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
418136004932	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
418136004933	dimer interface [polypeptide binding]; other site
418136004934	PYR/PP interface [polypeptide binding]; other site
418136004935	TPP binding site [chemical binding]; other site
418136004936	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
418136004937	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
418136004938	TPP-binding site [chemical binding]; other site
418136004939	dimer interface [polypeptide binding]; other site
418136004940	fragment
418136004941	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
418136004942	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
418136004943	tandem repeat interface [polypeptide binding]; other site
418136004944	oligomer interface [polypeptide binding]; other site
418136004945	active site residues [active]
418136004946	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
418136004947	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
418136004948	preprotein translocase subunit SecB; Provisional; Region: PRK13031
418136004949	SecA binding site; other site
418136004950	Preprotein binding site; other site
418136004951	recombinase A; Provisional; Region: recA; PRK09354
418136004952	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
418136004953	hexamer interface [polypeptide binding]; other site
418136004954	Walker A motif; other site
418136004955	ATP binding site [chemical binding]; other site
418136004956	Walker B motif; other site
418136004957	recombination regulator RecX; Reviewed; Region: recX; PRK00117
418136004958	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
418136004959	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
418136004960	dimer interface [polypeptide binding]; other site
418136004961	ssDNA binding site [nucleotide binding]; other site
418136004962	tetramer (dimer of dimers) interface [polypeptide binding]; other site
418136004963	propionate/acetate kinase; Provisional; Region: PRK12379
418136004964	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
418136004965	phosphate acetyltransferase; Reviewed; Region: PRK05632
418136004966	DRTGG domain; Region: DRTGG; pfam07085
418136004967	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
418136004968	contains frameshift
418136004969	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004970	Homeodomain-like domain; Region: HTH_23; cl17451
418136004971	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004972	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
418136004973	disruption due to transposon
418136004974	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
418136004975	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
418136004976	dimer interface [polypeptide binding]; other site
418136004977	anticodon binding site; other site
418136004978	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
418136004979	homodimer interface [polypeptide binding]; other site
418136004980	motif 1; other site
418136004981	active site
418136004982	motif 2; other site
418136004983	GAD domain; Region: GAD; pfam02938
418136004984	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
418136004985	active site
418136004986	motif 3; other site
418136004987	contains frameshifts
418136004988	disruption due to transposon insertion and frameshift
418136004989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
418136004990	Homeodomain-like domain; Region: HTH_23; cl17451
418136004991	DDE superfamily endonuclease; Region: DDE_3; pfam13358
418136004992	Methyltransferase domain; Region: Methyltransf_31; pfam13847
418136004993	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
418136004994	S-adenosylmethionine binding site [chemical binding]; other site
418136004995	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
418136004996	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
418136004997	Walker A/P-loop; other site
418136004998	ATP binding site [chemical binding]; other site
418136004999	Q-loop/lid; other site
418136005000	ABC transporter signature motif; other site
418136005001	Walker B; other site
418136005002	D-loop; other site
418136005003	H-loop/switch region; other site
418136005004	ABC transporter; Region: ABC_tran_2; pfam12848
418136005005	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
418136005006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
418136005007	metabolite-proton symporter; Region: 2A0106; TIGR00883
418136005008	putative substrate translocation pore; other site
418136005009	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
418136005010	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
418136005011	LysE type translocator; Region: LysE; cl00565
418136005012	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
418136005013	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
418136005014	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
418136005015	dimerization interface [polypeptide binding]; other site
418136005016	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
418136005017	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
418136005018	contains frameshift
418136005019	disruption due to transposon insertion and frameshift
418136005020	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
418136005021	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
418136005022	putative dimer interface [polypeptide binding]; other site
418136005023	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
418136005024	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
418136005025	active site
418136005026	ribulose/triose binding site [chemical binding]; other site
418136005027	phosphate binding site [ion binding]; other site
418136005028	substrate (anthranilate) binding pocket [chemical binding]; other site
418136005029	product (indole) binding pocket [chemical binding]; other site
418136005030	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
418136005031	active site
418136005032	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
418136005033	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
418136005034	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
418136005035	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
418136005036	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
418136005037	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
418136005038	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
418136005039	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
418136005040	Glutamine amidotransferase class-I; Region: GATase; pfam00117
418136005041	glutamine binding [chemical binding]; other site
418136005042	catalytic triad [active]
418136005043	anthranilate synthase component I; Provisional; Region: PRK13564
418136005044	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
418136005045	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
418136005046	Trp repressor protein; Region: Trp_repressor; cl17266
418136005047	ribonuclease G; Provisional; Region: PRK11712
418136005048	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
418136005049	homodimer interface [polypeptide binding]; other site
418136005050	oligonucleotide binding site [chemical binding]; other site