-- dump date 20140619_095220 -- class Genbank::misc_feature -- table misc_feature_note -- id note 351581000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 351581000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 351581000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351581000004 Walker A motif; other site 351581000005 ATP binding site [chemical binding]; other site 351581000006 Walker B motif; other site 351581000007 arginine finger; other site 351581000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 351581000009 DnaA box-binding interface [nucleotide binding]; other site 351581000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 351581000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 351581000012 putative DNA binding surface [nucleotide binding]; other site 351581000013 dimer interface [polypeptide binding]; other site 351581000014 beta-clamp/clamp loader binding surface; other site 351581000015 beta-clamp/translesion DNA polymerase binding surface; other site 351581000016 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 351581000017 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 351581000018 tandem repeat interface [polypeptide binding]; other site 351581000019 oligomer interface [polypeptide binding]; other site 351581000020 active site residues [active] 351581000021 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 351581000022 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 351581000023 preprotein translocase subunit SecB; Provisional; Region: PRK13031 351581000024 SecA binding site; other site 351581000025 Preprotein binding site; other site 351581000026 recombinase A; Provisional; Region: recA; PRK09354 351581000027 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 351581000028 hexamer interface [polypeptide binding]; other site 351581000029 Walker A motif; other site 351581000030 ATP binding site [chemical binding]; other site 351581000031 Walker B motif; other site 351581000032 recombination regulator RecX; Reviewed; Region: recX; PRK00117 351581000033 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 351581000034 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 351581000035 dimer interface [polypeptide binding]; other site 351581000036 ssDNA binding site [nucleotide binding]; other site 351581000037 tetramer (dimer of dimers) interface [polypeptide binding]; other site 351581000038 propionate/acetate kinase; Provisional; Region: PRK12379 351581000039 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 351581000040 phosphate acetyltransferase; Reviewed; Region: PRK05632 351581000041 DRTGG domain; Region: DRTGG; pfam07085 351581000042 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 351581000043 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 351581000044 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 351581000045 dimer interface [polypeptide binding]; other site 351581000046 anticodon binding site; other site 351581000047 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 351581000048 homodimer interface [polypeptide binding]; other site 351581000049 motif 1; other site 351581000050 active site 351581000051 motif 2; other site 351581000052 GAD domain; Region: GAD; pfam02938 351581000053 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 351581000054 active site 351581000055 motif 3; other site 351581000056 metabolite-proton symporter; Region: 2A0106; TIGR00883 351581000057 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 351581000058 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 351581000059 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 351581000060 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 351581000061 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 351581000062 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 351581000063 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 351581000064 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 351581000065 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 351581000066 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 351581000067 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 351581000068 ATP-grasp domain; Region: ATP-grasp_4; cl17255 351581000069 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 351581000070 substrate binding site [chemical binding]; other site 351581000071 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 351581000072 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 351581000073 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 351581000074 catalytic site [active] 351581000075 subunit interface [polypeptide binding]; other site 351581000076 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 351581000077 catalytic core [active] 351581000078 thiopurine S-methyltransferase; Reviewed; Region: PRK13256 351581000079 dihydroorotase; Reviewed; Region: PRK09236 351581000080 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 351581000081 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 351581000082 active site 351581000083 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 351581000084 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 351581000085 HlyD family secretion protein; Region: HlyD; pfam00529 351581000086 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351581000087 HlyD family secretion protein; Region: HlyD_3; pfam13437 351581000088 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 351581000089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351581000090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351581000091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 351581000092 dimerization interface [polypeptide binding]; other site 351581000093 Chorismate mutase type II; Region: CM_2; smart00830 351581000094 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 351581000095 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 351581000096 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 351581000097 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 351581000098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 351581000099 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 351581000100 active site 351581000101 dimer interface [polypeptide binding]; other site 351581000102 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 351581000103 phosphate binding site [ion binding]; other site 351581000104 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 351581000105 putative active site [active] 351581000106 dimerization interface [polypeptide binding]; other site 351581000107 putative tRNAtyr binding site [nucleotide binding]; other site 351581000108 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 351581000109 putative FMN binding site [chemical binding]; other site 351581000110 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 351581000111 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 351581000112 aromatic amino acid transport protein; Region: araaP; TIGR00837 351581000113 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 351581000114 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 351581000115 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 351581000116 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 351581000117 catalytic residue [active] 351581000118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581000119 putative substrate translocation pore; other site 351581000120 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 351581000121 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 351581000122 dimer interface [polypeptide binding]; other site 351581000123 active site 351581000124 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 351581000125 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 351581000126 GTP-binding protein LepA; Provisional; Region: PRK05433 351581000127 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 351581000128 G1 box; other site 351581000129 putative GEF interaction site [polypeptide binding]; other site 351581000130 GTP/Mg2+ binding site [chemical binding]; other site 351581000131 Switch I region; other site 351581000132 G2 box; other site 351581000133 G3 box; other site 351581000134 Switch II region; other site 351581000135 G4 box; other site 351581000136 G5 box; other site 351581000137 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 351581000138 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 351581000139 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 351581000140 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 351581000141 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 351581000142 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 351581000143 active site 351581000144 catalytic residues [active] 351581000145 metal binding site [ion binding]; metal-binding site 351581000146 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 351581000147 homopentamer interface [polypeptide binding]; other site 351581000148 active site 351581000149 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 351581000150 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 351581000151 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 351581000152 dimerization interface [polypeptide binding]; other site 351581000153 active site 351581000154 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 351581000155 Lumazine binding domain; Region: Lum_binding; pfam00677 351581000156 Lumazine binding domain; Region: Lum_binding; pfam00677 351581000157 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 351581000158 catalytic motif [active] 351581000159 Zn binding site [ion binding]; other site 351581000160 RibD C-terminal domain; Region: RibD_C; cl17279 351581000161 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 351581000162 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854 351581000163 hypothetical protein; Provisional; Region: PRK05421 351581000164 putative catalytic site [active] 351581000165 putative metal binding site [ion binding]; other site 351581000166 putative phosphate binding site [ion binding]; other site 351581000167 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 351581000168 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 351581000169 putative acyl-acceptor binding pocket; other site 351581000170 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 351581000171 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 351581000172 putative acyl-acceptor binding pocket; other site 351581000173 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 351581000174 4Fe-4S binding domain; Region: Fer4; cl02805 351581000175 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 351581000176 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 351581000177 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 351581000178 ATP-grasp domain; Region: ATP-grasp; pfam02222 351581000179 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 351581000180 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 351581000181 active site 351581000182 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 351581000183 Clp amino terminal domain; Region: Clp_N; pfam02861 351581000184 Clp amino terminal domain; Region: Clp_N; pfam02861 351581000185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351581000186 Walker A motif; other site 351581000187 ATP binding site [chemical binding]; other site 351581000188 Walker B motif; other site 351581000189 arginine finger; other site 351581000190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351581000191 Walker A motif; other site 351581000192 ATP binding site [chemical binding]; other site 351581000193 Walker B motif; other site 351581000194 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 351581000195 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 351581000196 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 351581000197 substrate binding site [chemical binding]; other site 351581000198 active site 351581000199 catalytic residues [active] 351581000200 heterodimer interface [polypeptide binding]; other site 351581000201 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 351581000202 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 351581000203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351581000204 catalytic residue [active] 351581000205 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 351581000206 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 351581000207 active site 351581000208 Zn binding site [ion binding]; other site 351581000209 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 351581000210 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 351581000211 Cl- selectivity filter; other site 351581000212 Cl- binding residues [ion binding]; other site 351581000213 pore gating glutamate residue; other site 351581000214 dimer interface [polypeptide binding]; other site 351581000215 H+/Cl- coupling transport residue; other site 351581000216 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 351581000217 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 351581000218 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 351581000219 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 351581000220 Protein of unknown function (DUF877); Region: DUF877; pfam05943 351581000221 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 351581000222 Intracellular growth locus C protein; Region: IglC; pfam11550 351581000223 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 351581000224 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 351581000225 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 351581000226 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 351581000227 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 351581000228 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 351581000229 homodimer interface [polypeptide binding]; other site 351581000230 substrate-cofactor binding pocket; other site 351581000231 catalytic residue [active] 351581000232 pyruvate phosphate dikinase; Provisional; Region: PRK09279 351581000233 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 351581000234 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 351581000235 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 351581000236 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 351581000237 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 351581000238 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 351581000239 G1 box; other site 351581000240 GTP/Mg2+ binding site [chemical binding]; other site 351581000241 Switch I region; other site 351581000242 G2 box; other site 351581000243 G3 box; other site 351581000244 Switch II region; other site 351581000245 G4 box; other site 351581000246 G5 box; other site 351581000247 Nucleoside recognition; Region: Gate; pfam07670 351581000248 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 351581000249 Nucleoside recognition; Region: Gate; pfam07670 351581000250 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 351581000251 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 351581000252 RNB domain; Region: RNB; pfam00773 351581000253 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 351581000254 putative hydrolase; Provisional; Region: PRK11460 351581000255 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 351581000256 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 351581000257 domain interfaces; other site 351581000258 active site 351581000259 Zinc-finger domain; Region: zf-CHCC; cl01821 351581000260 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 351581000261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351581000262 dimer interface [polypeptide binding]; other site 351581000263 conserved gate region; other site 351581000264 putative PBP binding loops; other site 351581000265 ABC-ATPase subunit interface; other site 351581000266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351581000267 dimer interface [polypeptide binding]; other site 351581000268 conserved gate region; other site 351581000269 putative PBP binding loops; other site 351581000270 ABC-ATPase subunit interface; other site 351581000271 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 351581000272 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 351581000273 Walker A/P-loop; other site 351581000274 ATP binding site [chemical binding]; other site 351581000275 Q-loop/lid; other site 351581000276 ABC transporter signature motif; other site 351581000277 Walker B; other site 351581000278 D-loop; other site 351581000279 H-loop/switch region; other site 351581000280 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 351581000281 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 351581000282 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 351581000283 TrkA-N domain; Region: TrkA_N; pfam02254 351581000284 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 351581000285 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 351581000286 trimer interface [polypeptide binding]; other site 351581000287 putative metal binding site [ion binding]; other site 351581000288 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 351581000289 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 351581000290 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 351581000291 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 351581000292 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 351581000293 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 351581000294 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 351581000295 LamB/YcsF family protein; Provisional; Region: PRK05406 351581000296 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 351581000297 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 351581000298 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 351581000299 Ligand Binding Site [chemical binding]; other site 351581000300 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 351581000301 Ligand Binding Site [chemical binding]; other site 351581000302 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 351581000303 PLD-like domain; Region: PLDc_2; pfam13091 351581000304 putative homodimer interface [polypeptide binding]; other site 351581000305 putative active site [active] 351581000306 catalytic site [active] 351581000307 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 351581000308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351581000309 ATP binding site [chemical binding]; other site 351581000310 putative Mg++ binding site [ion binding]; other site 351581000311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351581000312 nucleotide binding region [chemical binding]; other site 351581000313 ATP-binding site [chemical binding]; other site 351581000314 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 351581000315 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 351581000316 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 351581000317 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 351581000318 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 351581000319 Mitochondrial PGP phosphatase; Region: PGP_phosphatase; pfam09419 351581000320 Predicted methyltransferases [General function prediction only]; Region: COG0313 351581000321 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 351581000322 putative SAM binding site [chemical binding]; other site 351581000323 putative homodimer interface [polypeptide binding]; other site 351581000324 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 351581000325 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 351581000326 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 351581000327 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 351581000328 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 351581000329 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 351581000330 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 351581000331 shikimate binding site; other site 351581000332 NAD(P) binding site [chemical binding]; other site 351581000333 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 351581000334 Ribonuclease P; Region: Ribonuclease_P; pfam00825 351581000335 hypothetical protein; Provisional; Region: PRK14375 351581000336 membrane protein insertase; Provisional; Region: PRK01318 351581000337 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 351581000338 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 351581000339 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 351581000340 putative acyl-acceptor binding pocket; other site 351581000341 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 351581000342 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 351581000343 putative acyl-acceptor binding pocket; other site 351581000344 elongation factor P; Validated; Region: PRK00529 351581000345 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 351581000346 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 351581000347 RNA binding site [nucleotide binding]; other site 351581000348 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 351581000349 RNA binding site [nucleotide binding]; other site 351581000350 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 351581000351 catalytic site [active] 351581000352 putative active site [active] 351581000353 putative substrate binding site [chemical binding]; other site 351581000354 dimer interface [polypeptide binding]; other site 351581000355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581000356 putative substrate translocation pore; other site 351581000357 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 351581000358 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 351581000359 substrate binding pocket [chemical binding]; other site 351581000360 membrane-bound complex binding site; other site 351581000361 hinge residues; other site 351581000362 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 351581000363 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 351581000364 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 351581000365 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 351581000366 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 351581000367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581000368 Major Facilitator Superfamily; Region: MFS_1; pfam07690 351581000369 putative substrate translocation pore; other site 351581000370 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 351581000371 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 351581000372 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 351581000373 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 351581000374 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 351581000375 D-pathway; other site 351581000376 Putative ubiquinol binding site [chemical binding]; other site 351581000377 Low-spin heme (heme b) binding site [chemical binding]; other site 351581000378 Putative water exit pathway; other site 351581000379 Binuclear center (heme o3/CuB) [ion binding]; other site 351581000380 K-pathway; other site 351581000381 Putative proton exit pathway; other site 351581000382 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 351581000383 Subunit I/III interface [polypeptide binding]; other site 351581000384 Subunit III/IV interface [polypeptide binding]; other site 351581000385 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 351581000386 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 351581000387 UbiA prenyltransferase family; Region: UbiA; pfam01040 351581000388 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 351581000389 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 351581000390 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 351581000391 trimer interface [polypeptide binding]; other site 351581000392 active site 351581000393 UDP-GlcNAc binding site [chemical binding]; other site 351581000394 lipid binding site [chemical binding]; lipid-binding site 351581000395 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 351581000396 pyridoxamine kinase; Validated; Region: PRK05756 351581000397 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 351581000398 dimer interface [polypeptide binding]; other site 351581000399 pyridoxal binding site [chemical binding]; other site 351581000400 ATP binding site [chemical binding]; other site 351581000401 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 351581000402 MoxR-like ATPases [General function prediction only]; Region: COG0714 351581000403 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 351581000404 Walker A motif; other site 351581000405 ATP binding site [chemical binding]; other site 351581000406 Walker B motif; other site 351581000407 arginine finger; other site 351581000408 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 351581000409 Protein of unknown function DUF58; Region: DUF58; pfam01882 351581000410 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 351581000411 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 351581000412 metal ion-dependent adhesion site (MIDAS); other site 351581000413 hypothetical protein; Provisional; Region: PRK13685 351581000414 von Willebrand factor type A domain; Region: VWA_2; pfam13519 351581000415 metal ion-dependent adhesion site (MIDAS); other site 351581000416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351581000417 Tetratricopeptide repeat; Region: TPR_16; pfam13432 351581000418 TPR motif; other site 351581000419 binding surface 351581000420 Oxygen tolerance; Region: BatD; pfam13584 351581000421 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 351581000422 putative substrate binding pocket [chemical binding]; other site 351581000423 AC domain interface; other site 351581000424 catalytic triad [active] 351581000425 AB domain interface; other site 351581000426 interchain disulfide; other site 351581000427 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 351581000428 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 351581000429 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 351581000430 active site 351581000431 HIGH motif; other site 351581000432 nucleotide binding site [chemical binding]; other site 351581000433 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 351581000434 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 351581000435 active site 351581000436 KMSKS motif; other site 351581000437 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 351581000438 tRNA binding surface [nucleotide binding]; other site 351581000439 anticodon binding site; other site 351581000440 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 351581000441 1-deoxy-D-xylulose-5-phosphate synthase; Region: PLN02225 351581000442 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 351581000443 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 351581000444 phosphate binding site [ion binding]; other site 351581000445 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 351581000446 dimer interface [polypeptide binding]; other site 351581000447 FMN binding site [chemical binding]; other site 351581000448 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 351581000449 nudix motif; other site 351581000450 fumarate hydratase; Reviewed; Region: fumC; PRK00485 351581000451 Class II fumarases; Region: Fumarase_classII; cd01362 351581000452 active site 351581000453 tetramer interface [polypeptide binding]; other site 351581000454 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 351581000455 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 351581000456 HIGH motif; other site 351581000457 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 351581000458 active site 351581000459 KMSKS motif; other site 351581000460 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 351581000461 Amidinotransferase; Region: Amidinotransf; pfam02274 351581000462 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 351581000463 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 351581000464 folate binding site [chemical binding]; other site 351581000465 NADP+ binding site [chemical binding]; other site 351581000466 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 351581000467 rRNA interaction site [nucleotide binding]; other site 351581000468 S8 interaction site; other site 351581000469 putative laminin-1 binding site; other site 351581000470 elongation factor Ts; Provisional; Region: tsf; PRK09377 351581000471 UBA/TS-N domain; Region: UBA; pfam00627 351581000472 Elongation factor TS; Region: EF_TS; pfam00889 351581000473 Elongation factor TS; Region: EF_TS; pfam00889 351581000474 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 351581000475 putative nucleotide binding site [chemical binding]; other site 351581000476 uridine monophosphate binding site [chemical binding]; other site 351581000477 homohexameric interface [polypeptide binding]; other site 351581000478 ribosome recycling factor; Reviewed; Region: frr; PRK00083 351581000479 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 351581000480 hinge region; other site 351581000481 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 351581000482 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 351581000483 catalytic residue [active] 351581000484 putative FPP diphosphate binding site; other site 351581000485 putative FPP binding hydrophobic cleft; other site 351581000486 dimer interface [polypeptide binding]; other site 351581000487 putative IPP diphosphate binding site; other site 351581000488 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 351581000489 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 351581000490 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 351581000491 trimer interface [polypeptide binding]; other site 351581000492 active site 351581000493 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 351581000494 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 351581000495 S17 interaction site [polypeptide binding]; other site 351581000496 S8 interaction site; other site 351581000497 16S rRNA interaction site [nucleotide binding]; other site 351581000498 streptomycin interaction site [chemical binding]; other site 351581000499 23S rRNA interaction site [nucleotide binding]; other site 351581000500 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 351581000501 30S ribosomal protein S7; Validated; Region: PRK05302 351581000502 elongation factor G; Reviewed; Region: PRK00007 351581000503 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 351581000504 G1 box; other site 351581000505 putative GEF interaction site [polypeptide binding]; other site 351581000506 GTP/Mg2+ binding site [chemical binding]; other site 351581000507 Switch I region; other site 351581000508 G2 box; other site 351581000509 G3 box; other site 351581000510 Switch II region; other site 351581000511 G4 box; other site 351581000512 G5 box; other site 351581000513 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 351581000514 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 351581000515 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 351581000516 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 351581000517 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 351581000518 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 351581000519 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 351581000520 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 351581000521 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 351581000522 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 351581000523 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 351581000524 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 351581000525 putative translocon binding site; other site 351581000526 protein-rRNA interface [nucleotide binding]; other site 351581000527 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 351581000528 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 351581000529 G-X-X-G motif; other site 351581000530 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 351581000531 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 351581000532 23S rRNA interface [nucleotide binding]; other site 351581000533 5S rRNA interface [nucleotide binding]; other site 351581000534 putative antibiotic binding site [chemical binding]; other site 351581000535 L25 interface [polypeptide binding]; other site 351581000536 L27 interface [polypeptide binding]; other site 351581000537 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 351581000538 23S rRNA interface [nucleotide binding]; other site 351581000539 putative translocon interaction site; other site 351581000540 signal recognition particle (SRP54) interaction site; other site 351581000541 L23 interface [polypeptide binding]; other site 351581000542 trigger factor interaction site; other site 351581000543 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 351581000544 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 351581000545 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 351581000546 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 351581000547 RNA binding site [nucleotide binding]; other site 351581000548 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 351581000549 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 351581000550 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 351581000551 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 351581000552 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 351581000553 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 351581000554 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 351581000555 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 351581000556 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 351581000557 23S rRNA interface [nucleotide binding]; other site 351581000558 L21e interface [polypeptide binding]; other site 351581000559 5S rRNA interface [nucleotide binding]; other site 351581000560 L27 interface [polypeptide binding]; other site 351581000561 L5 interface [polypeptide binding]; other site 351581000562 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 351581000563 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 351581000564 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 351581000565 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 351581000566 23S rRNA binding site [nucleotide binding]; other site 351581000567 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 351581000568 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 351581000569 SecY translocase; Region: SecY; pfam00344 351581000570 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 351581000571 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 351581000572 30S ribosomal protein S13; Region: bact_S13; TIGR03631 351581000573 30S ribosomal protein S11; Validated; Region: PRK05309 351581000574 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 351581000575 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 351581000576 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351581000577 RNA binding surface [nucleotide binding]; other site 351581000578 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 351581000579 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 351581000580 alphaNTD homodimer interface [polypeptide binding]; other site 351581000581 alphaNTD - beta interaction site [polypeptide binding]; other site 351581000582 alphaNTD - beta' interaction site [polypeptide binding]; other site 351581000583 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 351581000584 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 351581000585 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 351581000586 heat shock protein 90; Provisional; Region: PRK05218 351581000587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351581000588 ATP binding site [chemical binding]; other site 351581000589 Mg2+ binding site [ion binding]; other site 351581000590 G-X-G motif; other site 351581000591 glutamate dehydrogenase; Provisional; Region: PRK09414 351581000592 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 351581000593 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 351581000594 NAD(P) binding site [chemical binding]; other site 351581000595 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 351581000596 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 351581000597 active site 351581000598 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 351581000599 substrate binding site [chemical binding]; other site 351581000600 catalytic residues [active] 351581000601 dimer interface [polypeptide binding]; other site 351581000602 Amino acid permease; Region: AA_permease_2; pfam13520 351581000603 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 351581000604 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 351581000605 DNA binding site [nucleotide binding] 351581000606 active site 351581000607 Uncharacterized conserved protein [Function unknown]; Region: COG0398 351581000608 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 351581000609 mercuric reductase; Validated; Region: PRK06370 351581000610 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 351581000611 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 351581000612 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 351581000613 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 351581000614 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 351581000615 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 351581000616 HSP70 interaction site [polypeptide binding]; other site 351581000617 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 351581000618 substrate binding site [polypeptide binding]; other site 351581000619 dimer interface [polypeptide binding]; other site 351581000620 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 351581000621 EamA-like transporter family; Region: EamA; pfam00892 351581000622 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 351581000623 Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; Region: PI3Ka; cl00271 351581000624 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 351581000625 HD domain; Region: HD_4; pfam13328 351581000626 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 351581000627 synthetase active site [active] 351581000628 NTP binding site [chemical binding]; other site 351581000629 metal binding site [ion binding]; metal-binding site 351581000630 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 351581000631 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 351581000632 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 351581000633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351581000634 S-adenosylmethionine binding site [chemical binding]; other site 351581000635 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 351581000636 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 351581000637 active site 351581000638 DNA binding site [nucleotide binding] 351581000639 Int/Topo IB signature motif; other site 351581000640 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 351581000641 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 351581000642 preprotein translocase subunit SecB; Validated; Region: PRK05751 351581000643 SecA binding site; other site 351581000644 Preprotein binding site; other site 351581000645 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 351581000646 MutS domain I; Region: MutS_I; pfam01624 351581000647 MutS domain III; Region: MutS_III; pfam05192 351581000648 MutS domain V; Region: MutS_V; pfam00488 351581000649 Walker A/P-loop; other site 351581000650 ATP binding site [chemical binding]; other site 351581000651 Q-loop/lid; other site 351581000652 ABC transporter signature motif; other site 351581000653 Walker B; other site 351581000654 D-loop; other site 351581000655 H-loop/switch region; other site 351581000656 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 351581000657 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 351581000658 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 351581000659 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 351581000660 putative active site [active] 351581000661 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 351581000662 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 351581000663 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 351581000664 active site 351581000665 HIGH motif; other site 351581000666 dimer interface [polypeptide binding]; other site 351581000667 KMSKS motif; other site 351581000668 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 351581000669 dephospho-CoA kinase; Region: TIGR00152 351581000670 CoA-binding site [chemical binding]; other site 351581000671 ATP-binding [chemical binding]; other site 351581000672 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 351581000673 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 351581000674 dimer interface [polypeptide binding]; other site 351581000675 TPP-binding site [chemical binding]; other site 351581000676 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 351581000677 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 351581000678 E3 interaction surface; other site 351581000679 lipoyl attachment site [posttranslational modification]; other site 351581000680 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 351581000681 E3 interaction surface; other site 351581000682 lipoyl attachment site [posttranslational modification]; other site 351581000683 e3 binding domain; Region: E3_binding; pfam02817 351581000684 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 351581000685 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 351581000686 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 351581000687 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 351581000688 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 351581000689 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 351581000690 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 351581000691 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 351581000692 nudix motif; other site 351581000693 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 351581000694 ArsC family; Region: ArsC; pfam03960 351581000695 catalytic residue [active] 351581000696 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 351581000697 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 351581000698 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 351581000699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351581000700 homodimer interface [polypeptide binding]; other site 351581000701 catalytic residue [active] 351581000702 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 351581000703 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 351581000704 ligand binding site [chemical binding]; other site 351581000705 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 351581000706 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 351581000707 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 351581000708 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 351581000709 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 351581000710 homotrimer interaction site [polypeptide binding]; other site 351581000711 active site 351581000712 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 351581000713 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 351581000714 TolQ protein; Region: tolQ; TIGR02796 351581000715 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 351581000716 TolR protein; Region: tolR; TIGR02801 351581000717 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 351581000718 TolB amino-terminal domain; Region: TolB_N; pfam04052 351581000719 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 351581000720 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 351581000721 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 351581000722 ligand binding site [chemical binding]; other site 351581000723 bile acid transporter; Region: bass; TIGR00841 351581000724 Sodium Bile acid symporter family; Region: SBF; cl17470 351581000725 Protein of unknown function, DUF393; Region: DUF393; pfam04134 351581000726 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 351581000727 UbiA prenyltransferase family; Region: UbiA; pfam01040 351581000728 Chorismate lyase; Region: Chor_lyase; cl01230 351581000729 ribonuclease PH; Reviewed; Region: rph; PRK00173 351581000730 Ribonuclease PH; Region: RNase_PH_bact; cd11362 351581000731 hexamer interface [polypeptide binding]; other site 351581000732 active site 351581000733 heat shock protein HtpX; Provisional; Region: PRK02870 351581000734 LemA family; Region: LemA; cl00742 351581000735 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351581000736 dimerization interface [polypeptide binding]; other site 351581000737 putative DNA binding site [nucleotide binding]; other site 351581000738 putative Zn2+ binding site [ion binding]; other site 351581000739 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 351581000740 putative active site [active] 351581000741 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 351581000742 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 351581000743 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 351581000744 Colicin V production protein; Region: Colicin_V; pfam02674 351581000745 DNA repair protein RadA; Provisional; Region: PRK11823 351581000746 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 351581000747 Walker A motif/ATP binding site; other site 351581000748 ATP binding site [chemical binding]; other site 351581000749 Walker B motif; other site 351581000750 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 351581000751 PilZ domain; Region: PilZ; pfam07238 351581000752 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 351581000753 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 351581000754 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 351581000755 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 351581000756 Tetramer interface [polypeptide binding]; other site 351581000757 active site 351581000758 FMN-binding site [chemical binding]; other site 351581000759 PQ loop repeat; Region: PQ-loop; pfam04193 351581000760 methionine sulfoxide reductase B; Provisional; Region: PRK00222 351581000761 SelR domain; Region: SelR; pfam01641 351581000762 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 351581000763 E-class dimer interface [polypeptide binding]; other site 351581000764 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 351581000765 P-class dimer interface [polypeptide binding]; other site 351581000766 active site 351581000767 Cu2+ binding site [ion binding]; other site 351581000768 Zn2+ binding site [ion binding]; other site 351581000769 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 351581000770 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 351581000771 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 351581000772 Cupin domain; Region: Cupin_2; cl17218 351581000773 aspartate aminotransferase; Provisional; Region: PRK07568 351581000774 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 351581000775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351581000776 homodimer interface [polypeptide binding]; other site 351581000777 catalytic residue [active] 351581000778 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 351581000779 Cation efflux family; Region: Cation_efflux; pfam01545 351581000780 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 351581000781 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 351581000782 Walker A/P-loop; other site 351581000783 ATP binding site [chemical binding]; other site 351581000784 Q-loop/lid; other site 351581000785 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 351581000786 ABC transporter signature motif; other site 351581000787 Walker B; other site 351581000788 D-loop; other site 351581000789 H-loop/switch region; other site 351581000790 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 351581000791 Pilin (bacterial filament); Region: Pilin; pfam00114 351581000792 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 351581000793 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 351581000794 active site 351581000795 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 351581000796 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 351581000797 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 351581000798 homodimer interface [polypeptide binding]; other site 351581000799 NADP binding site [chemical binding]; other site 351581000800 substrate binding site [chemical binding]; other site 351581000801 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 351581000802 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 351581000803 dimerization interface [polypeptide binding]; other site 351581000804 putative ATP binding site [chemical binding]; other site 351581000805 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 351581000806 active site 351581000807 ATP binding site [chemical binding]; other site 351581000808 substrate binding site [chemical binding]; other site 351581000809 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 351581000810 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 351581000811 ATP-grasp domain; Region: ATP-grasp_4; cl17255 351581000812 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 351581000813 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 351581000814 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 351581000815 active site 351581000816 substrate binding site [chemical binding]; other site 351581000817 cosubstrate binding site; other site 351581000818 catalytic site [active] 351581000819 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 351581000820 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 351581000821 ATP-grasp domain; Region: ATP-grasp; pfam02222 351581000822 intracellular septation protein A; Reviewed; Region: PRK00259 351581000823 Glucokinase; Region: Glucokinase; pfam02685 351581000824 glucokinase, proteobacterial type; Region: glk; TIGR00749 351581000825 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 351581000826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351581000827 S-adenosylmethionine binding site [chemical binding]; other site 351581000828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 351581000829 ABC1 family; Region: ABC1; cl17513 351581000830 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 351581000831 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 351581000832 nucleotide binding site/active site [active] 351581000833 HIT family signature motif; other site 351581000834 catalytic residue [active] 351581000835 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 351581000836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351581000837 active site 351581000838 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 351581000839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 351581000840 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 351581000841 FAD binding domain; Region: FAD_binding_4; pfam01565 351581000842 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 351581000843 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 351581000844 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 351581000845 putative active site [active] 351581000846 GTP-binding protein Der; Reviewed; Region: PRK00093 351581000847 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 351581000848 G1 box; other site 351581000849 GTP/Mg2+ binding site [chemical binding]; other site 351581000850 Switch I region; other site 351581000851 G2 box; other site 351581000852 Switch II region; other site 351581000853 G3 box; other site 351581000854 G4 box; other site 351581000855 G5 box; other site 351581000856 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 351581000857 G1 box; other site 351581000858 GTP/Mg2+ binding site [chemical binding]; other site 351581000859 Switch I region; other site 351581000860 G2 box; other site 351581000861 G3 box; other site 351581000862 Switch II region; other site 351581000863 G4 box; other site 351581000864 G5 box; other site 351581000865 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 351581000866 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 351581000867 active site 351581000868 Zn binding site [ion binding]; other site 351581000869 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 351581000870 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 351581000871 DNA topoisomerase I; Validated; Region: PRK06599 351581000872 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 351581000873 active site 351581000874 interdomain interaction site; other site 351581000875 putative metal-binding site [ion binding]; other site 351581000876 nucleotide binding site [chemical binding]; other site 351581000877 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 351581000878 domain I; other site 351581000879 DNA binding groove [nucleotide binding] 351581000880 phosphate binding site [ion binding]; other site 351581000881 domain II; other site 351581000882 domain III; other site 351581000883 nucleotide binding site [chemical binding]; other site 351581000884 catalytic site [active] 351581000885 domain IV; other site 351581000886 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 351581000887 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 351581000888 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 351581000889 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 351581000890 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 351581000891 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 351581000892 P-loop; other site 351581000893 Magnesium ion binding site [ion binding]; other site 351581000894 ParB-like nuclease domain; Region: ParB; smart00470 351581000895 KorB domain; Region: KorB; pfam08535 351581000896 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 351581000897 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 351581000898 catalytic triad [active] 351581000899 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 351581000900 active site 351581000901 catalytic triad [active] 351581000902 oxyanion hole [active] 351581000903 FtsJ-like methyltransferase; Region: FtsJ; cl17430 351581000904 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 351581000905 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 351581000906 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 351581000907 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 351581000908 active site 351581000909 HIGH motif; other site 351581000910 nucleotide binding site [chemical binding]; other site 351581000911 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 351581000912 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 351581000913 active site 351581000914 KMSKS motif; other site 351581000915 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 351581000916 tRNA binding surface [nucleotide binding]; other site 351581000917 anticodon binding site; other site 351581000918 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 351581000919 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 351581000920 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 351581000921 active site 351581000922 Riboflavin kinase; Region: Flavokinase; pfam01687 351581000923 malate dehydrogenase; Provisional; Region: PRK13529 351581000924 Malic enzyme, N-terminal domain; Region: malic; pfam00390 351581000925 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 351581000926 NAD(P) binding pocket [chemical binding]; other site 351581000927 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 351581000928 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 351581000929 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 351581000930 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 351581000931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581000932 D-galactonate transporter; Region: 2A0114; TIGR00893 351581000933 putative substrate translocation pore; other site 351581000934 Predicted flavoprotein [General function prediction only]; Region: COG0431 351581000935 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 351581000936 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 351581000937 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 351581000938 Peptidase family M50; Region: Peptidase_M50; pfam02163 351581000939 active site 351581000940 putative substrate binding region [chemical binding]; other site 351581000941 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 351581000942 DNA binding residues [nucleotide binding] 351581000943 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 351581000944 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 351581000945 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 351581000946 active site 351581000947 (T/H)XGH motif; other site 351581000948 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 351581000949 nudix motif; other site 351581000950 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 351581000951 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 351581000952 Substrate binding site; other site 351581000953 Mg++ binding site; other site 351581000954 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 351581000955 active site 351581000956 substrate binding site [chemical binding]; other site 351581000957 CoA binding site [chemical binding]; other site 351581000958 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 351581000959 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 351581000960 glutaminase active site [active] 351581000961 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 351581000962 dimer interface [polypeptide binding]; other site 351581000963 active site 351581000964 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 351581000965 dimer interface [polypeptide binding]; other site 351581000966 active site 351581000967 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 351581000968 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 351581000969 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 351581000970 DNA-binding site [nucleotide binding]; DNA binding site 351581000971 RNA-binding motif; other site 351581000972 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 351581000973 metal binding site [ion binding]; metal-binding site 351581000974 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 351581000975 active site 351581000976 PLD-like domain; Region: PLDc_2; pfam13091 351581000977 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 351581000978 putative homodimer interface [polypeptide binding]; other site 351581000979 putative active site [active] 351581000980 catalytic site [active] 351581000981 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 351581000982 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 351581000983 CAP-like domain; other site 351581000984 active site 351581000985 primary dimer interface [polypeptide binding]; other site 351581000986 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 351581000987 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 351581000988 BNR repeat-like domain; Region: BNR_2; pfam13088 351581000989 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 351581000990 Asp-box motif; other site 351581000991 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 351581000992 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 351581000993 N-acetyl-D-glucosamine binding site [chemical binding]; other site 351581000994 catalytic residue [active] 351581000995 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 351581000996 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 351581000997 putative active site [active] 351581000998 putative PHP Thumb interface [polypeptide binding]; other site 351581000999 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 351581001000 generic binding surface II; other site 351581001001 generic binding surface I; other site 351581001002 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 351581001003 active site 351581001004 catalytic residues [active] 351581001005 metal binding site [ion binding]; metal-binding site 351581001006 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 351581001007 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 351581001008 FtsX-like permease family; Region: FtsX; pfam02687 351581001009 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 351581001010 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 351581001011 Walker A/P-loop; other site 351581001012 ATP binding site [chemical binding]; other site 351581001013 Q-loop/lid; other site 351581001014 ABC transporter signature motif; other site 351581001015 Walker B; other site 351581001016 D-loop; other site 351581001017 H-loop/switch region; other site 351581001018 lysine decarboxylase LdcC; Provisional; Region: PRK15399 351581001019 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 351581001020 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 351581001021 homodimer interface [polypeptide binding]; other site 351581001022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351581001023 catalytic residue [active] 351581001024 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 351581001025 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 351581001026 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 351581001027 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 351581001028 lipoyl attachment site [posttranslational modification]; other site 351581001029 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 351581001030 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 351581001031 tetramer interface [polypeptide binding]; other site 351581001032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351581001033 catalytic residue [active] 351581001034 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 351581001035 tetramer interface [polypeptide binding]; other site 351581001036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351581001037 catalytic residue [active] 351581001038 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 351581001039 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 351581001040 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 351581001041 shikimate binding site; other site 351581001042 NAD(P) binding site [chemical binding]; other site 351581001043 pullulanase, type I; Region: pulA_typeI; TIGR02104 351581001044 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 351581001045 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 351581001046 Ca binding site [ion binding]; other site 351581001047 active site 351581001048 catalytic site [active] 351581001049 glycogen branching enzyme; Provisional; Region: PRK12313 351581001050 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 351581001051 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 351581001052 active site 351581001053 catalytic site [active] 351581001054 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 351581001055 phosphoglucomutase; Region: PLN02307 351581001056 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 351581001057 substrate binding site [chemical binding]; other site 351581001058 dimer interface [polypeptide binding]; other site 351581001059 active site 351581001060 metal binding site [ion binding]; metal-binding site 351581001061 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 351581001062 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 351581001063 ligand binding site; other site 351581001064 oligomer interface; other site 351581001065 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 351581001066 dimer interface [polypeptide binding]; other site 351581001067 N-terminal domain interface [polypeptide binding]; other site 351581001068 sulfate 1 binding site; other site 351581001069 glycogen synthase; Provisional; Region: glgA; PRK00654 351581001070 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 351581001071 ADP-binding pocket [chemical binding]; other site 351581001072 homodimer interface [polypeptide binding]; other site 351581001073 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 351581001074 homodimer interface [polypeptide binding]; other site 351581001075 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 351581001076 active site pocket [active] 351581001077 4-alpha-glucanotransferase; Provisional; Region: PRK14508 351581001078 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 351581001079 dimer interface [polypeptide binding]; other site 351581001080 motif 1; other site 351581001081 active site 351581001082 motif 2; other site 351581001083 motif 3; other site 351581001084 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 351581001085 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 351581001086 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 351581001087 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 351581001088 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 351581001089 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 351581001090 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 351581001091 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 351581001092 threonine synthase; Validated; Region: PRK09225 351581001093 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 351581001094 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351581001095 catalytic residue [active] 351581001096 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 351581001097 spermidine synthase; Provisional; Region: PRK00811 351581001098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351581001099 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 351581001100 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 351581001101 putative active site [active] 351581001102 putative metal binding site [ion binding]; other site 351581001103 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351581001104 active site 351581001105 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 351581001106 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 351581001107 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 351581001108 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 351581001109 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 351581001110 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 351581001111 BolA-like protein; Region: BolA; cl00386 351581001112 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 351581001113 anti sigma factor interaction site; other site 351581001114 regulatory phosphorylation site [posttranslational modification]; other site 351581001115 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 351581001116 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 351581001117 mce related protein; Region: MCE; pfam02470 351581001118 Permease; Region: Permease; pfam02405 351581001119 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 351581001120 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 351581001121 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 351581001122 Walker A/P-loop; other site 351581001123 ATP binding site [chemical binding]; other site 351581001124 Q-loop/lid; other site 351581001125 ABC transporter signature motif; other site 351581001126 Walker B; other site 351581001127 D-loop; other site 351581001128 H-loop/switch region; other site 351581001129 cell division topological specificity factor MinE; Provisional; Region: PRK13990 351581001130 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 351581001131 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 351581001132 Switch I; other site 351581001133 Switch II; other site 351581001134 septum formation inhibitor; Reviewed; Region: minC; PRK04804 351581001135 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 351581001136 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 351581001137 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 351581001138 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 351581001139 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 351581001140 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 351581001141 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 351581001142 ssDNA binding site; other site 351581001143 generic binding surface II; other site 351581001144 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351581001145 ATP binding site [chemical binding]; other site 351581001146 putative Mg++ binding site [ion binding]; other site 351581001147 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351581001148 nucleotide binding region [chemical binding]; other site 351581001149 ATP-binding site [chemical binding]; other site 351581001150 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 351581001151 Fumarase C-terminus; Region: Fumerase_C; pfam05683 351581001152 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 351581001153 GIY-YIG motif/motif A; other site 351581001154 putative active site [active] 351581001155 putative metal binding site [ion binding]; other site 351581001156 Restriction endonuclease [Defense mechanisms]; Region: COG3587 351581001157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351581001158 ATP binding site [chemical binding]; other site 351581001159 putative Mg++ binding site [ion binding]; other site 351581001160 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 351581001161 ligand binding site [chemical binding]; other site 351581001162 active site 351581001163 UGI interface [polypeptide binding]; other site 351581001164 catalytic site [active] 351581001165 DNA gyrase subunit A; Validated; Region: PRK05560 351581001166 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 351581001167 CAP-like domain; other site 351581001168 active site 351581001169 primary dimer interface [polypeptide binding]; other site 351581001170 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 351581001171 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 351581001172 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 351581001173 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 351581001174 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 351581001175 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 351581001176 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 351581001177 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 351581001178 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 351581001179 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 351581001180 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 351581001181 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 351581001182 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 351581001183 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 351581001184 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 351581001185 Surface antigen; Region: Bac_surface_Ag; pfam01103 351581001186 periplasmic chaperone; Provisional; Region: PRK10780 351581001187 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 351581001188 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 351581001189 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 351581001190 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 351581001191 trimer interface [polypeptide binding]; other site 351581001192 active site 351581001193 UDP-GlcNAc binding site [chemical binding]; other site 351581001194 lipid binding site [chemical binding]; lipid-binding site 351581001195 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 351581001196 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 351581001197 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 351581001198 active site 351581001199 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 351581001200 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 351581001201 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 351581001202 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 351581001203 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 351581001204 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 351581001205 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 351581001206 substrate binding pocket [chemical binding]; other site 351581001207 chain length determination region; other site 351581001208 substrate-Mg2+ binding site; other site 351581001209 catalytic residues [active] 351581001210 aspartate-rich region 1; other site 351581001211 active site lid residues [active] 351581001212 aspartate-rich region 2; other site 351581001213 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 351581001214 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 351581001215 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 351581001216 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 351581001217 active site 351581001218 dimerization interface [polypeptide binding]; other site 351581001219 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 351581001220 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 351581001221 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 351581001222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 351581001223 active site 351581001224 phosphorylation site [posttranslational modification] 351581001225 intermolecular recognition site; other site 351581001226 dimerization interface [polypeptide binding]; other site 351581001227 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 351581001228 DNA binding site [nucleotide binding] 351581001229 signal peptidase I; Provisional; Region: PRK10861 351581001230 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 351581001231 Catalytic site [active] 351581001232 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 351581001233 ribonuclease III; Reviewed; Region: rnc; PRK00102 351581001234 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 351581001235 dimerization interface [polypeptide binding]; other site 351581001236 active site 351581001237 metal binding site [ion binding]; metal-binding site 351581001238 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 351581001239 dsRNA binding site [nucleotide binding]; other site 351581001240 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 351581001241 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 351581001242 RNA binding site [nucleotide binding]; other site 351581001243 active site 351581001244 ribonuclease R; Region: RNase_R; TIGR02063 351581001245 RNB domain; Region: RNB; pfam00773 351581001246 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 351581001247 RNA binding site [nucleotide binding]; other site 351581001248 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 351581001249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351581001250 NAD(P) binding site [chemical binding]; other site 351581001251 active site 351581001252 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 351581001253 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 351581001254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 351581001255 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 351581001256 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 351581001257 active site 351581001258 Protein of unknown function (DUF465); Region: DUF465; pfam04325 351581001259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581001260 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 351581001261 putative substrate translocation pore; other site 351581001262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 351581001263 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 351581001264 CoenzymeA binding site [chemical binding]; other site 351581001265 subunit interaction site [polypeptide binding]; other site 351581001266 PHB binding site; other site 351581001267 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 351581001268 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 351581001269 dimer interface [polypeptide binding]; other site 351581001270 active site 351581001271 Acyl CoA binding protein; Region: ACBP; pfam00887 351581001272 acyl-CoA binding pocket [chemical binding]; other site 351581001273 CoA binding site [chemical binding]; other site 351581001274 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 351581001275 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 351581001276 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 351581001277 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 351581001278 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 351581001279 substrate binding site [chemical binding]; other site 351581001280 oxyanion hole (OAH) forming residues; other site 351581001281 trimer interface [polypeptide binding]; other site 351581001282 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 351581001283 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 351581001284 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 351581001285 active site 351581001286 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 351581001287 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 351581001288 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 351581001289 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 351581001290 acyl-activating enzyme (AAE) consensus motif; other site 351581001291 AMP binding site [chemical binding]; other site 351581001292 active site 351581001293 CoA binding site [chemical binding]; other site 351581001294 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 351581001295 ArsC family; Region: ArsC; pfam03960 351581001296 catalytic residues [active] 351581001297 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 351581001298 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 351581001299 DEAD-like helicases superfamily; Region: DEXDc; smart00487 351581001300 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351581001301 ATP binding site [chemical binding]; other site 351581001302 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 351581001303 putative Mg++ binding site [ion binding]; other site 351581001304 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351581001305 nucleotide binding region [chemical binding]; other site 351581001306 ATP-binding site [chemical binding]; other site 351581001307 Helicase associated domain (HA2); Region: HA2; pfam04408 351581001308 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 351581001309 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 351581001310 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 351581001311 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 351581001312 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 351581001313 NAD(P) binding site [chemical binding]; other site 351581001314 homodimer interface [polypeptide binding]; other site 351581001315 substrate binding site [chemical binding]; other site 351581001316 active site 351581001317 Bacterial sugar transferase; Region: Bac_transf; pfam02397 351581001318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351581001319 NADH(P)-binding; Region: NAD_binding_10; pfam13460 351581001320 NAD(P) binding site [chemical binding]; other site 351581001321 active site 351581001322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 351581001323 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 351581001324 putative ADP-binding pocket [chemical binding]; other site 351581001325 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 351581001326 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 351581001327 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 351581001328 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 351581001329 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 351581001330 NAD binding site [chemical binding]; other site 351581001331 substrate binding site [chemical binding]; other site 351581001332 homodimer interface [polypeptide binding]; other site 351581001333 active site 351581001334 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 351581001335 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 351581001336 putative ADP-binding pocket [chemical binding]; other site 351581001337 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 351581001338 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 351581001339 active site 351581001340 dimer interface [polypeptide binding]; other site 351581001341 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 351581001342 Ligand Binding Site [chemical binding]; other site 351581001343 Molecular Tunnel; other site 351581001344 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 351581001345 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 351581001346 inhibitor-cofactor binding pocket; inhibition site 351581001347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351581001348 catalytic residue [active] 351581001349 hypothetical protein; Provisional; Region: PRK07579 351581001350 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 351581001351 active site 351581001352 cosubstrate binding site; other site 351581001353 substrate binding site [chemical binding]; other site 351581001354 catalytic site [active] 351581001355 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 351581001356 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 351581001357 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 351581001358 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 351581001359 active site 351581001360 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 351581001361 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 351581001362 substrate binding site; other site 351581001363 tetramer interface; other site 351581001364 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 351581001365 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 351581001366 NAD binding site [chemical binding]; other site 351581001367 substrate binding site [chemical binding]; other site 351581001368 homodimer interface [polypeptide binding]; other site 351581001369 active site 351581001370 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 351581001371 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 351581001372 Substrate binding site; other site 351581001373 Cupin domain; Region: Cupin_2; cl17218 351581001374 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 351581001375 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 351581001376 active site 351581001377 substrate binding site [chemical binding]; other site 351581001378 metal binding site [ion binding]; metal-binding site 351581001379 transcription termination factor Rho; Provisional; Region: rho; PRK09376 351581001380 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 351581001381 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 351581001382 RNA binding site [nucleotide binding]; other site 351581001383 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 351581001384 multimer interface [polypeptide binding]; other site 351581001385 Walker A motif; other site 351581001386 ATP binding site [chemical binding]; other site 351581001387 Walker B motif; other site 351581001388 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 351581001389 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 351581001390 catalytic residues [active] 351581001391 exopolyphosphatase; Region: exo_poly_only; TIGR03706 351581001392 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 351581001393 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 351581001394 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 351581001395 dimer interface [polypeptide binding]; other site 351581001396 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 351581001397 Ferritin-like domain; Region: Ferritin; pfam00210 351581001398 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 351581001399 dinuclear metal binding motif [ion binding]; other site 351581001400 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 351581001401 active site 351581001402 hypothetical protein; Provisional; Region: PRK10621 351581001403 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 351581001404 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 351581001405 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 351581001406 Walker A/P-loop; other site 351581001407 ATP binding site [chemical binding]; other site 351581001408 Q-loop/lid; other site 351581001409 ABC transporter signature motif; other site 351581001410 Walker B; other site 351581001411 D-loop; other site 351581001412 H-loop/switch region; other site 351581001413 inner membrane transport permease; Provisional; Region: PRK15066 351581001414 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 351581001415 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 351581001416 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 351581001417 Ligand binding site; other site 351581001418 Putative Catalytic site; other site 351581001419 DXD motif; other site 351581001420 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 351581001421 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 351581001422 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 351581001423 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 351581001424 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351581001425 putative DNA binding site [nucleotide binding]; other site 351581001426 putative Zn2+ binding site [ion binding]; other site 351581001427 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 351581001428 active site residue [active] 351581001429 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 351581001430 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 351581001431 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 351581001432 hypothetical protein; Provisional; Region: PRK05170 351581001433 transcription antitermination factor NusB; Region: nusB; TIGR01951 351581001434 putative RNA binding site [nucleotide binding]; other site 351581001435 C-N hydrolase family amidase; Provisional; Region: PRK10438 351581001436 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 351581001437 putative active site [active] 351581001438 catalytic triad [active] 351581001439 dimer interface [polypeptide binding]; other site 351581001440 multimer interface [polypeptide binding]; other site 351581001441 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 351581001442 prolyl-tRNA synthetase; Provisional; Region: PRK09194 351581001443 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 351581001444 dimer interface [polypeptide binding]; other site 351581001445 motif 1; other site 351581001446 active site 351581001447 motif 2; other site 351581001448 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 351581001449 putative deacylase active site [active] 351581001450 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 351581001451 active site 351581001452 motif 3; other site 351581001453 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 351581001454 anticodon binding site; other site 351581001455 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 351581001456 nucleic acid binding site [nucleotide binding]; other site 351581001457 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 351581001458 Fe-S metabolism associated domain; Region: SufE; cl00951 351581001459 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 351581001460 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 351581001461 active site 351581001462 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 351581001463 Sporulation related domain; Region: SPOR; pfam05036 351581001464 FeoA domain; Region: FeoA; cl00838 351581001465 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 351581001466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 351581001467 non-specific DNA binding site [nucleotide binding]; other site 351581001468 salt bridge; other site 351581001469 sequence-specific DNA binding site [nucleotide binding]; other site 351581001470 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 351581001471 Catalytic site [active] 351581001472 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 351581001473 EamA-like transporter family; Region: EamA; pfam00892 351581001474 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 351581001475 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 351581001476 active site 351581001477 FMN binding site [chemical binding]; other site 351581001478 substrate binding site [chemical binding]; other site 351581001479 3Fe-4S cluster binding site [ion binding]; other site 351581001480 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 351581001481 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 351581001482 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 351581001483 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 351581001484 Divergent AAA domain; Region: AAA_4; pfam04326 351581001485 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 351581001486 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351581001487 putative DNA binding site [nucleotide binding]; other site 351581001488 putative Zn2+ binding site [ion binding]; other site 351581001489 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 351581001490 Family description; Region: UvrD_C_2; pfam13538 351581001491 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 351581001492 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 351581001493 AAA domain; Region: AAA_30; pfam13604 351581001494 Family description; Region: UvrD_C_2; pfam13538 351581001495 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 351581001496 nucleotide binding site [chemical binding]; other site 351581001497 Type III pantothenate kinase; Region: Pan_kinase; cl17198 351581001498 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 351581001499 tetramerization interface [polypeptide binding]; other site 351581001500 active site 351581001501 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 351581001502 pantoate--beta-alanine ligase; Region: panC; TIGR00018 351581001503 active site 351581001504 nucleotide binding site [chemical binding]; other site 351581001505 HIGH motif; other site 351581001506 KMSKS motif; other site 351581001507 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 351581001508 active site 351581001509 oligomerization interface [polypeptide binding]; other site 351581001510 metal binding site [ion binding]; metal-binding site 351581001511 Uncharacterized conserved protein [Function unknown]; Region: COG5495 351581001512 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 351581001513 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 351581001514 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 351581001515 nucleotide binding pocket [chemical binding]; other site 351581001516 K-X-D-G motif; other site 351581001517 catalytic site [active] 351581001518 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 351581001519 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 351581001520 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 351581001521 Dimer interface [polypeptide binding]; other site 351581001522 BRCT sequence motif; other site 351581001523 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 351581001524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351581001525 dimer interface [polypeptide binding]; other site 351581001526 conserved gate region; other site 351581001527 putative PBP binding loops; other site 351581001528 ABC-ATPase subunit interface; other site 351581001529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351581001530 dimer interface [polypeptide binding]; other site 351581001531 conserved gate region; other site 351581001532 putative PBP binding loops; other site 351581001533 ABC-ATPase subunit interface; other site 351581001534 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 351581001535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351581001536 Walker A/P-loop; other site 351581001537 ATP binding site [chemical binding]; other site 351581001538 Q-loop/lid; other site 351581001539 ABC transporter signature motif; other site 351581001540 Walker B; other site 351581001541 D-loop; other site 351581001542 H-loop/switch region; other site 351581001543 TOBE domain; Region: TOBE_2; pfam08402 351581001544 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 351581001545 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 351581001546 homodimer interface [polypeptide binding]; other site 351581001547 NAD binding pocket [chemical binding]; other site 351581001548 ATP binding pocket [chemical binding]; other site 351581001549 Mg binding site [ion binding]; other site 351581001550 active-site loop [active] 351581001551 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 351581001552 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 351581001553 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351581001554 HlyD family secretion protein; Region: HlyD_3; pfam13437 351581001555 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 351581001556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581001557 putative substrate translocation pore; other site 351581001558 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 351581001559 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 351581001560 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 351581001561 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 351581001562 acyl-activating enzyme (AAE) consensus motif; other site 351581001563 putative AMP binding site [chemical binding]; other site 351581001564 putative active site [active] 351581001565 putative CoA binding site [chemical binding]; other site 351581001566 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 351581001567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581001568 putative substrate translocation pore; other site 351581001569 POT family; Region: PTR2; cl17359 351581001570 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 351581001571 RNA methyltransferase, RsmE family; Region: TIGR00046 351581001572 Protein of unknown function (DUF445); Region: DUF445; pfam04286 351581001573 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 351581001574 mce related protein; Region: MCE; pfam02470 351581001575 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 351581001576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351581001577 Walker A/P-loop; other site 351581001578 ATP binding site [chemical binding]; other site 351581001579 Q-loop/lid; other site 351581001580 ABC transporter signature motif; other site 351581001581 Walker B; other site 351581001582 D-loop; other site 351581001583 H-loop/switch region; other site 351581001584 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 351581001585 Permease; Region: Permease; pfam02405 351581001586 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 351581001587 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 351581001588 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351581001589 RNA binding surface [nucleotide binding]; other site 351581001590 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 351581001591 active site 351581001592 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 351581001593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 351581001594 TPR motif; other site 351581001595 binding surface 351581001596 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 351581001597 FAD binding domain; Region: FAD_binding_4; pfam01565 351581001598 Berberine and berberine like; Region: BBE; pfam08031 351581001599 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 351581001600 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 351581001601 dimer interface [polypeptide binding]; other site 351581001602 active site 351581001603 glycine-pyridoxal phosphate binding site [chemical binding]; other site 351581001604 folate binding site [chemical binding]; other site 351581001605 hypothetical protein; Provisional; Region: PRK05255 351581001606 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 351581001607 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 351581001608 Ligand binding site; other site 351581001609 metal-binding site 351581001610 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 351581001611 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 351581001612 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 351581001613 Ligand Binding Site [chemical binding]; other site 351581001614 TilS substrate C-terminal domain; Region: TilS_C; smart00977 351581001615 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 351581001616 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 351581001617 ligand binding site [chemical binding]; other site 351581001618 NAD binding site [chemical binding]; other site 351581001619 tetramer interface [polypeptide binding]; other site 351581001620 catalytic site [active] 351581001621 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 351581001622 L-serine binding site [chemical binding]; other site 351581001623 ACT domain interface; other site 351581001624 thymidylate synthase; Reviewed; Region: thyA; PRK01827 351581001625 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 351581001626 dimerization interface [polypeptide binding]; other site 351581001627 active site 351581001628 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 351581001629 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 351581001630 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 351581001631 homodimer interface [polypeptide binding]; other site 351581001632 oligonucleotide binding site [chemical binding]; other site 351581001633 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 351581001634 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 351581001635 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351581001636 catalytic residue [active] 351581001637 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 351581001638 Recombination protein O N terminal; Region: RecO_N; pfam11967 351581001639 Recombination protein O C terminal; Region: RecO_C; pfam02565 351581001640 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 351581001641 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 351581001642 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 351581001643 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 351581001644 BolA-like protein; Region: BolA; cl00386 351581001645 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 351581001646 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 351581001647 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 351581001648 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 351581001649 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 351581001650 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 351581001651 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 351581001652 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 351581001653 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 351581001654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351581001655 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 351581001656 active site 351581001657 motif I; other site 351581001658 motif II; other site 351581001659 Soluble P-type ATPase [General function prediction only]; Region: COG4087 351581001660 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 351581001661 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 351581001662 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 351581001663 dimer interface [polypeptide binding]; other site 351581001664 active site 351581001665 metal binding site [ion binding]; metal-binding site 351581001666 glutathione binding site [chemical binding]; other site 351581001667 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 351581001668 tetramer (dimer of dimers) interface [polypeptide binding]; other site 351581001669 active site 351581001670 dimer interface [polypeptide binding]; other site 351581001671 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 351581001672 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 351581001673 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 351581001674 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 351581001675 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 351581001676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351581001677 NAD(P) binding site [chemical binding]; other site 351581001678 active site 351581001679 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 351581001680 active site 351581001681 catalytic site [active] 351581001682 substrate binding site [chemical binding]; other site 351581001683 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 351581001684 excinuclease ABC subunit B; Provisional; Region: PRK05298 351581001685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351581001686 ATP binding site [chemical binding]; other site 351581001687 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351581001688 nucleotide binding region [chemical binding]; other site 351581001689 ATP-binding site [chemical binding]; other site 351581001690 Ultra-violet resistance protein B; Region: UvrB; pfam12344 351581001691 UvrB/uvrC motif; Region: UVR; pfam02151 351581001692 Nuclease-related domain; Region: NERD; pfam08378 351581001693 glutamate racemase; Provisional; Region: PRK00865 351581001694 metabolite-proton symporter; Region: 2A0106; TIGR00883 351581001695 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 351581001696 putative dimer interface [polypeptide binding]; other site 351581001697 putative active site [active] 351581001698 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 351581001699 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 351581001700 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 351581001701 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 351581001702 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 351581001703 generic binding surface II; other site 351581001704 generic binding surface I; other site 351581001705 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 351581001706 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 351581001707 Ligand Binding Site [chemical binding]; other site 351581001708 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 351581001709 SmpB-tmRNA interface; other site 351581001710 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 351581001711 putative coenzyme Q binding site [chemical binding]; other site 351581001712 hypothetical protein; Validated; Region: PRK01777 351581001713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 351581001714 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 351581001715 VacJ like lipoprotein; Region: VacJ; cl01073 351581001716 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 351581001717 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 351581001718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351581001719 S-adenosylmethionine binding site [chemical binding]; other site 351581001720 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 351581001721 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 351581001722 G1 box; other site 351581001723 putative GEF interaction site [polypeptide binding]; other site 351581001724 GTP/Mg2+ binding site [chemical binding]; other site 351581001725 Switch I region; other site 351581001726 G2 box; other site 351581001727 G3 box; other site 351581001728 Switch II region; other site 351581001729 G4 box; other site 351581001730 G5 box; other site 351581001731 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 351581001732 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 351581001733 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 351581001734 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 351581001735 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 351581001736 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 351581001737 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 351581001738 DNA-binding site [nucleotide binding]; DNA binding site 351581001739 RNA-binding motif; other site 351581001740 Sel1-like repeats; Region: SEL1; smart00671 351581001741 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 351581001742 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 351581001743 GTP/Mg2+ binding site [chemical binding]; other site 351581001744 G4 box; other site 351581001745 G5 box; other site 351581001746 G1 box; other site 351581001747 Switch I region; other site 351581001748 G2 box; other site 351581001749 G3 box; other site 351581001750 Switch II region; other site 351581001751 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 351581001752 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 351581001753 active site 351581001754 dimer interface [polypeptide binding]; other site 351581001755 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 351581001756 Glycoprotease family; Region: Peptidase_M22; pfam00814 351581001757 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 351581001758 putative active site [active] 351581001759 putative dimer interface [polypeptide binding]; other site 351581001760 aspartate aminotransferase; Provisional; Region: PRK05764 351581001761 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 351581001762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351581001763 homodimer interface [polypeptide binding]; other site 351581001764 catalytic residue [active] 351581001765 GTPase Era; Reviewed; Region: era; PRK00089 351581001766 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 351581001767 G1 box; other site 351581001768 GTP/Mg2+ binding site [chemical binding]; other site 351581001769 Switch I region; other site 351581001770 G2 box; other site 351581001771 Switch II region; other site 351581001772 G3 box; other site 351581001773 G4 box; other site 351581001774 G5 box; other site 351581001775 adenylate kinase; Reviewed; Region: adk; PRK00279 351581001776 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 351581001777 AMP-binding site [chemical binding]; other site 351581001778 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 351581001779 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 351581001780 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 351581001781 Pilus assembly protein, PilO; Region: PilO; cl01234 351581001782 Pilus assembly protein, PilP; Region: PilP; pfam04351 351581001783 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 351581001784 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 351581001785 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 351581001786 shikimate kinase; Reviewed; Region: aroK; PRK00131 351581001787 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 351581001788 ADP binding site [chemical binding]; other site 351581001789 magnesium binding site [ion binding]; other site 351581001790 putative shikimate binding site; other site 351581001791 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 351581001792 active site 351581001793 dimer interface [polypeptide binding]; other site 351581001794 metal binding site [ion binding]; metal-binding site 351581001795 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 351581001796 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 351581001797 Proline dehydrogenase; Region: Pro_dh; pfam01619 351581001798 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 351581001799 Glutamate binding site [chemical binding]; other site 351581001800 NAD binding site [chemical binding]; other site 351581001801 catalytic residues [active] 351581001802 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 351581001803 NAD(P) binding site [chemical binding]; other site 351581001804 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 351581001805 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 351581001806 benzoate transport; Region: 2A0115; TIGR00895 351581001807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581001808 putative substrate translocation pore; other site 351581001809 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 351581001810 Flavoprotein; Region: Flavoprotein; pfam02441 351581001811 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 351581001812 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 351581001813 ferrochelatase; Reviewed; Region: hemH; PRK00035 351581001814 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 351581001815 C-terminal domain interface [polypeptide binding]; other site 351581001816 active site 351581001817 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 351581001818 active site 351581001819 N-terminal domain interface [polypeptide binding]; other site 351581001820 Predicted membrane protein [Function unknown]; Region: COG1511 351581001821 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 351581001822 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 351581001823 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 351581001824 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 351581001825 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 351581001826 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 351581001827 Walker A motif; other site 351581001828 ATP binding site [chemical binding]; other site 351581001829 Walker B motif; other site 351581001830 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 351581001831 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 351581001832 active site 351581001833 catalytic site [active] 351581001834 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 351581001835 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 351581001836 putative MPT binding site; other site 351581001837 cyanophycin synthetase; Provisional; Region: PRK14016 351581001838 ATP-grasp domain; Region: ATP-grasp_4; cl17255 351581001839 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 351581001840 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 351581001841 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 351581001842 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 351581001843 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 351581001844 homotrimer interaction site [polypeptide binding]; other site 351581001845 zinc binding site [ion binding]; other site 351581001846 CDP-binding sites; other site 351581001847 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 351581001848 active site residue [active] 351581001849 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 351581001850 active site residue [active] 351581001851 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 351581001852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 351581001853 dimer interface [polypeptide binding]; other site 351581001854 conserved gate region; other site 351581001855 putative PBP binding loops; other site 351581001856 ABC-ATPase subunit interface; other site 351581001857 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 351581001858 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 351581001859 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 351581001860 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 351581001861 Walker A/P-loop; other site 351581001862 ATP binding site [chemical binding]; other site 351581001863 Q-loop/lid; other site 351581001864 ABC transporter signature motif; other site 351581001865 Walker B; other site 351581001866 D-loop; other site 351581001867 H-loop/switch region; other site 351581001868 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 351581001869 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 351581001870 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 351581001871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 351581001872 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 351581001873 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 351581001874 Isochorismatase family; Region: Isochorismatase; pfam00857 351581001875 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 351581001876 catalytic triad [active] 351581001877 conserved cis-peptide bond; other site 351581001878 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 351581001879 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 351581001880 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 351581001881 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 351581001882 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 351581001883 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 351581001884 Protein export membrane protein; Region: SecD_SecF; pfam02355 351581001885 Src Homology 3 domain superfamily; Region: SH3; cl17036 351581001886 peptide ligand binding site [polypeptide binding]; other site 351581001887 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 351581001888 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 351581001889 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 351581001890 DNA binding residues [nucleotide binding] 351581001891 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 351581001892 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 351581001893 hinge; other site 351581001894 active site 351581001895 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 351581001896 RNA/DNA hybrid binding site [nucleotide binding]; other site 351581001897 active site 351581001898 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 351581001899 active site 351581001900 homodimer interface [polypeptide binding]; other site 351581001901 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 351581001902 active site clefts [active] 351581001903 zinc binding site [ion binding]; other site 351581001904 dimer interface [polypeptide binding]; other site 351581001905 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 351581001906 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 351581001907 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351581001908 catalytic residue [active] 351581001909 Rubredoxin [Energy production and conversion]; Region: COG1773 351581001910 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 351581001911 iron binding site [ion binding]; other site 351581001912 Uncharacterized conserved protein [Function unknown]; Region: COG0397 351581001913 hypothetical protein; Validated; Region: PRK00029 351581001914 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 351581001915 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 351581001916 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 351581001917 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 351581001918 dimer interface [polypeptide binding]; other site 351581001919 active site 351581001920 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 351581001921 dimer interface [polypeptide binding]; other site 351581001922 active site 351581001923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581001924 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 351581001925 putative substrate translocation pore; other site 351581001926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581001927 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 351581001928 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 351581001929 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 351581001930 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 351581001931 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 351581001932 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 351581001933 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 351581001934 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 351581001935 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 351581001936 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 351581001937 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 351581001938 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 351581001939 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 351581001940 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 351581001941 active site 351581001942 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 351581001943 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 351581001944 active site 351581001945 substrate binding site [chemical binding]; other site 351581001946 Mg2+ binding site [ion binding]; other site 351581001947 beta-lactamase TEM; Provisional; Region: PRK15442 351581001948 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 351581001949 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 351581001950 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 351581001951 putative active site [active] 351581001952 catalytic triad [active] 351581001953 putative dimer interface [polypeptide binding]; other site 351581001954 FOG: CBS domain [General function prediction only]; Region: COG0517 351581001955 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 351581001956 Transporter associated domain; Region: CorC_HlyC; smart01091 351581001957 metal-binding heat shock protein; Provisional; Region: PRK00016 351581001958 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 351581001959 PhoH-like protein; Region: PhoH; pfam02562 351581001960 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 351581001961 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 351581001962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351581001963 FeS/SAM binding site; other site 351581001964 TRAM domain; Region: TRAM; pfam01938 351581001965 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 351581001966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 351581001967 thymidine kinase; Provisional; Region: PRK04296 351581001968 trigger factor; Provisional; Region: tig; PRK01490 351581001969 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 351581001970 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 351581001971 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 351581001972 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 351581001973 oligomer interface [polypeptide binding]; other site 351581001974 active site residues [active] 351581001975 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 351581001976 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 351581001977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351581001978 Walker A motif; other site 351581001979 ATP binding site [chemical binding]; other site 351581001980 Walker B motif; other site 351581001981 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 351581001982 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 351581001983 Found in ATP-dependent protease La (LON); Region: LON; smart00464 351581001984 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351581001985 Walker A motif; other site 351581001986 ATP binding site [chemical binding]; other site 351581001987 Walker B motif; other site 351581001988 arginine finger; other site 351581001989 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 351581001990 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 351581001991 IHF dimer interface [polypeptide binding]; other site 351581001992 IHF - DNA interface [nucleotide binding]; other site 351581001993 SurA N-terminal domain; Region: SurA_N_3; cl07813 351581001994 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 351581001995 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 351581001996 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 351581001997 bacterial Hfq-like; Region: Hfq; cd01716 351581001998 hexamer interface [polypeptide binding]; other site 351581001999 Sm1 motif; other site 351581002000 RNA binding site [nucleotide binding]; other site 351581002001 Sm2 motif; other site 351581002002 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 351581002003 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 351581002004 HflX GTPase family; Region: HflX; cd01878 351581002005 G1 box; other site 351581002006 GTP/Mg2+ binding site [chemical binding]; other site 351581002007 Switch I region; other site 351581002008 G2 box; other site 351581002009 G3 box; other site 351581002010 Switch II region; other site 351581002011 G4 box; other site 351581002012 G5 box; other site 351581002013 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 351581002014 HflK protein; Region: hflK; TIGR01933 351581002015 FtsH protease regulator HflC; Provisional; Region: PRK11029 351581002016 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 351581002017 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 351581002018 Low molecular weight phosphatase family; Region: LMWPc; cd00115 351581002019 active site 351581002020 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 351581002021 G1 box; other site 351581002022 GTP/Mg2+ binding site [chemical binding]; other site 351581002023 Switch I region; other site 351581002024 G2 box; other site 351581002025 G3 box; other site 351581002026 Switch II region; other site 351581002027 G4 box; other site 351581002028 G5 box; other site 351581002029 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 351581002030 putative valine binding site [chemical binding]; other site 351581002031 dimer interface [polypeptide binding]; other site 351581002032 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 351581002033 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 351581002034 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 351581002035 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 351581002036 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 351581002037 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351581002038 ATP binding site [chemical binding]; other site 351581002039 putative Mg++ binding site [ion binding]; other site 351581002040 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351581002041 nucleotide binding region [chemical binding]; other site 351581002042 ATP-binding site [chemical binding]; other site 351581002043 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 351581002044 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 351581002045 YccA-like proteins; Region: YccA_like; cd10433 351581002046 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 351581002047 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 351581002048 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 351581002049 minor groove reading motif; other site 351581002050 helix-hairpin-helix signature motif; other site 351581002051 substrate binding pocket [chemical binding]; other site 351581002052 active site 351581002053 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 351581002054 ferredoxin; Provisional; Region: PRK08764 351581002055 Putative Fe-S cluster; Region: FeS; cl17515 351581002056 4Fe-4S binding domain; Region: Fer4; pfam00037 351581002057 glutaredoxin 2; Provisional; Region: PRK10387 351581002058 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 351581002059 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 351581002060 N-terminal domain interface [polypeptide binding]; other site 351581002061 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 351581002062 Ferritin-like domain; Region: Ferritin; pfam00210 351581002063 ferroxidase diiron center [ion binding]; other site 351581002064 lipoyl synthase; Provisional; Region: PRK05481 351581002065 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351581002066 FeS/SAM binding site; other site 351581002067 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 351581002068 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 351581002069 conserved cys residue [active] 351581002070 hypothetical protein; Validated; Region: PRK00110 351581002071 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 351581002072 active site 351581002073 putative DNA-binding cleft [nucleotide binding]; other site 351581002074 dimer interface [polypeptide binding]; other site 351581002075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581002076 putative substrate translocation pore; other site 351581002077 D-galactonate transporter; Region: 2A0114; TIGR00893 351581002078 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 351581002079 RuvA N terminal domain; Region: RuvA_N; pfam01330 351581002080 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 351581002081 RmuC family; Region: RmuC; pfam02646 351581002082 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 351581002083 dimerization interface [polypeptide binding]; other site 351581002084 putative Zn2+ binding site [ion binding]; other site 351581002085 putative DNA binding site [nucleotide binding]; other site 351581002086 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 351581002087 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 351581002088 histidine decarboxylase; Provisional; Region: PRK02769 351581002089 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351581002090 catalytic residue [active] 351581002091 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 351581002092 intersubunit interface [polypeptide binding]; other site 351581002093 active site 351581002094 Zn2+ binding site [ion binding]; other site 351581002095 Isochorismatase family; Region: Isochorismatase; pfam00857 351581002096 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 351581002097 catalytic triad [active] 351581002098 conserved cis-peptide bond; other site 351581002099 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 351581002100 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 351581002101 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 351581002102 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 351581002103 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 351581002104 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351581002105 active site 351581002106 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 351581002107 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 351581002108 5S rRNA interface [nucleotide binding]; other site 351581002109 CTC domain interface [polypeptide binding]; other site 351581002110 L16 interface [polypeptide binding]; other site 351581002111 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 351581002112 Domain of unknown function DUF21; Region: DUF21; pfam01595 351581002113 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 351581002114 Transporter associated domain; Region: CorC_HlyC; pfam03471 351581002115 GTP-binding protein YchF; Reviewed; Region: PRK09601 351581002116 YchF GTPase; Region: YchF; cd01900 351581002117 G1 box; other site 351581002118 GTP/Mg2+ binding site [chemical binding]; other site 351581002119 Switch I region; other site 351581002120 G2 box; other site 351581002121 Switch II region; other site 351581002122 G3 box; other site 351581002123 G4 box; other site 351581002124 G5 box; other site 351581002125 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 351581002126 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 351581002127 putative active site [active] 351581002128 catalytic residue [active] 351581002129 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 351581002130 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 351581002131 dimerization domain [polypeptide binding]; other site 351581002132 dimer interface [polypeptide binding]; other site 351581002133 catalytic residues [active] 351581002134 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 351581002135 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 351581002136 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 351581002137 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 351581002138 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 351581002139 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 351581002140 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 351581002141 POT family; Region: PTR2; cl17359 351581002142 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 351581002143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351581002144 Walker A motif; other site 351581002145 ATP binding site [chemical binding]; other site 351581002146 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 351581002147 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 351581002148 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 351581002149 active site 351581002150 HslU subunit interaction site [polypeptide binding]; other site 351581002151 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 351581002152 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 351581002153 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 351581002154 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 351581002155 active site 351581002156 HIGH motif; other site 351581002157 dimer interface [polypeptide binding]; other site 351581002158 KMSKS motif; other site 351581002159 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351581002160 RNA binding surface [nucleotide binding]; other site 351581002161 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 351581002162 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 351581002163 phosphate binding site [ion binding]; other site 351581002164 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 351581002165 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 351581002166 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 351581002167 dimer interface [polypeptide binding]; other site 351581002168 active site 351581002169 metal binding site [ion binding]; metal-binding site 351581002170 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 351581002171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351581002172 S-adenosylmethionine binding site [chemical binding]; other site 351581002173 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 351581002174 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 351581002175 FMN binding site [chemical binding]; other site 351581002176 active site 351581002177 catalytic residues [active] 351581002178 substrate binding site [chemical binding]; other site 351581002179 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 351581002180 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 351581002181 Methyltransferase domain; Region: Methyltransf_26; pfam13659 351581002182 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 351581002183 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 351581002184 putative active site [active] 351581002185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351581002186 Walker A/P-loop; other site 351581002187 ATP binding site [chemical binding]; other site 351581002188 AAA domain; Region: AAA_21; pfam13304 351581002189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 351581002190 ABC transporter signature motif; other site 351581002191 Walker B; other site 351581002192 D-loop; other site 351581002193 H-loop/switch region; other site 351581002194 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 351581002195 active site 351581002196 DNA polymerase IV; Validated; Region: PRK02406 351581002197 DNA binding site [nucleotide binding] 351581002198 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 351581002199 DJ-1 family protein; Region: not_thiJ; TIGR01383 351581002200 conserved cys residue [active] 351581002201 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 351581002202 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 351581002203 GSH binding site [chemical binding]; other site 351581002204 catalytic residues [active] 351581002205 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 351581002206 dimer interface [polypeptide binding]; other site 351581002207 putative radical transfer pathway; other site 351581002208 diiron center [ion binding]; other site 351581002209 tyrosyl radical; other site 351581002210 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 351581002211 GSH binding site [chemical binding]; other site 351581002212 catalytic residues [active] 351581002213 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 351581002214 Class I ribonucleotide reductase; Region: RNR_I; cd01679 351581002215 active site 351581002216 dimer interface [polypeptide binding]; other site 351581002217 catalytic residues [active] 351581002218 effector binding site; other site 351581002219 R2 peptide binding site; other site 351581002220 malate dehydrogenase; Reviewed; Region: PRK06223 351581002221 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 351581002222 NAD(P) binding site [chemical binding]; other site 351581002223 dimer interface [polypeptide binding]; other site 351581002224 tetramer (dimer of dimers) interface [polypeptide binding]; other site 351581002225 substrate binding site [chemical binding]; other site 351581002226 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 351581002227 diiron binding motif [ion binding]; other site 351581002228 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 351581002229 N-acetyl-D-glucosamine binding site [chemical binding]; other site 351581002230 catalytic residue [active] 351581002231 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 351581002232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351581002233 motif II; other site 351581002234 peroxidase; Provisional; Region: PRK15000 351581002235 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 351581002236 dimer interface [polypeptide binding]; other site 351581002237 decamer (pentamer of dimers) interface [polypeptide binding]; other site 351581002238 catalytic triad [active] 351581002239 peroxidatic and resolving cysteines [active] 351581002240 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 351581002241 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 351581002242 active site 351581002243 catalytic site [active] 351581002244 substrate binding site [chemical binding]; other site 351581002245 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 351581002246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 351581002247 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 351581002248 putative homodimer interface [polypeptide binding]; other site 351581002249 putative homotetramer interface [polypeptide binding]; other site 351581002250 putative allosteric switch controlling residues; other site 351581002251 putative metal binding site [ion binding]; other site 351581002252 putative homodimer-homodimer interface [polypeptide binding]; other site 351581002253 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 351581002254 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 351581002255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351581002256 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 351581002257 dimerization interface [polypeptide binding]; other site 351581002258 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 351581002259 catalytic triad [active] 351581002260 dimer interface [polypeptide binding]; other site 351581002261 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 351581002262 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 351581002263 putative NAD(P) binding site [chemical binding]; other site 351581002264 homodimer interface [polypeptide binding]; other site 351581002265 cytidylate kinase; Provisional; Region: cmk; PRK00023 351581002266 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 351581002267 CMP-binding site; other site 351581002268 The sites determining sugar specificity; other site 351581002269 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 351581002270 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351581002271 catalytic residue [active] 351581002272 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 351581002273 catalytic core [active] 351581002274 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 351581002275 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 351581002276 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 351581002277 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 351581002278 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 351581002279 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 351581002280 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 351581002281 replicative DNA helicase; Region: DnaB; TIGR00665 351581002282 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 351581002283 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 351581002284 Walker A motif; other site 351581002285 ATP binding site [chemical binding]; other site 351581002286 Walker B motif; other site 351581002287 DNA binding loops [nucleotide binding] 351581002288 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 351581002289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351581002290 FeS/SAM binding site; other site 351581002291 Tetratricopeptide repeat; Region: TPR_12; pfam13424 351581002292 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 351581002293 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351581002294 RNA binding surface [nucleotide binding]; other site 351581002295 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 351581002296 probable active site [active] 351581002297 preprotein translocase subunit SecA; Validated; Region: secA; CHL00122 351581002298 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 351581002299 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 351581002300 Coenzyme A binding pocket [chemical binding]; other site 351581002301 PQ loop repeat; Region: PQ-loop; pfam04193 351581002302 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 351581002303 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 351581002304 substrate binding pocket [chemical binding]; other site 351581002305 chain length determination region; other site 351581002306 substrate-Mg2+ binding site; other site 351581002307 catalytic residues [active] 351581002308 aspartate-rich region 1; other site 351581002309 active site lid residues [active] 351581002310 aspartate-rich region 2; other site 351581002311 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 351581002312 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 351581002313 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 351581002314 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 351581002315 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 351581002316 Ligand Binding Site [chemical binding]; other site 351581002317 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 351581002318 active site 351581002319 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 351581002320 N-acetyl-D-glucosamine binding site [chemical binding]; other site 351581002321 catalytic residue [active] 351581002322 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 351581002323 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 351581002324 Yqey-like protein; Region: YqeY; pfam09424 351581002325 CHC2 zinc finger; Region: zf-CHC2; pfam01807 351581002326 DNA primase; Validated; Region: dnaG; PRK05667 351581002327 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 351581002328 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 351581002329 active site 351581002330 metal binding site [ion binding]; metal-binding site 351581002331 interdomain interaction site; other site 351581002332 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 351581002333 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 351581002334 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 351581002335 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 351581002336 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 351581002337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 351581002338 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 351581002339 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 351581002340 DNA binding residues [nucleotide binding] 351581002341 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 351581002342 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 351581002343 lipoate-protein ligase B; Provisional; Region: PRK14342 351581002344 Protein of unknown function (DUF493); Region: DUF493; pfam04359 351581002345 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 351581002346 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 351581002347 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 351581002348 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 351581002349 dimer interface [polypeptide binding]; other site 351581002350 substrate binding site [chemical binding]; other site 351581002351 metal binding sites [ion binding]; metal-binding site 351581002352 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 351581002353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351581002354 active site 351581002355 motif I; other site 351581002356 motif II; other site 351581002357 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 351581002358 OstA-like protein; Region: OstA; cl00844 351581002359 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 351581002360 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 351581002361 Walker A/P-loop; other site 351581002362 ATP binding site [chemical binding]; other site 351581002363 Q-loop/lid; other site 351581002364 ABC transporter signature motif; other site 351581002365 Walker B; other site 351581002366 D-loop; other site 351581002367 H-loop/switch region; other site 351581002368 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 351581002369 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 351581002370 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 351581002371 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 351581002372 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 351581002373 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 351581002374 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 351581002375 dimerization interface 3.5A [polypeptide binding]; other site 351581002376 active site 351581002377 GMP synthase; Reviewed; Region: guaA; PRK00074 351581002378 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 351581002379 AMP/PPi binding site [chemical binding]; other site 351581002380 candidate oxyanion hole; other site 351581002381 catalytic triad [active] 351581002382 potential glutamine specificity residues [chemical binding]; other site 351581002383 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 351581002384 ATP Binding subdomain [chemical binding]; other site 351581002385 Ligand Binding sites [chemical binding]; other site 351581002386 Dimerization subdomain; other site 351581002387 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 351581002388 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 351581002389 TPP-binding site; other site 351581002390 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 351581002391 PYR/PP interface [polypeptide binding]; other site 351581002392 dimer interface [polypeptide binding]; other site 351581002393 TPP binding site [chemical binding]; other site 351581002394 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 351581002395 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 351581002396 putative active site pocket [active] 351581002397 dimerization interface [polypeptide binding]; other site 351581002398 putative catalytic residue [active] 351581002399 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 351581002400 active site 351581002401 catalytic triad [active] 351581002402 oxyanion hole [active] 351581002403 switch loop; other site 351581002404 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 351581002405 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 351581002406 classical (c) SDRs; Region: SDR_c; cd05233 351581002407 NAD(P) binding site [chemical binding]; other site 351581002408 active site 351581002409 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 351581002410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351581002411 Walker A motif; other site 351581002412 ATP binding site [chemical binding]; other site 351581002413 Walker B motif; other site 351581002414 arginine finger; other site 351581002415 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 351581002416 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 351581002417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 351581002418 non-specific DNA binding site [nucleotide binding]; other site 351581002419 salt bridge; other site 351581002420 sequence-specific DNA binding site [nucleotide binding]; other site 351581002421 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 351581002422 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 351581002423 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 351581002424 TspO/MBR family; Region: TspO_MBR; pfam03073 351581002425 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 351581002426 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 351581002427 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 351581002428 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 351581002429 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 351581002430 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 351581002431 catalytic residues [active] 351581002432 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 351581002433 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 351581002434 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 351581002435 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 351581002436 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 351581002437 motif 1; other site 351581002438 active site 351581002439 motif 2; other site 351581002440 motif 3; other site 351581002441 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 351581002442 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 351581002443 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 351581002444 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 351581002445 interface (dimer of trimers) [polypeptide binding]; other site 351581002446 Substrate-binding/catalytic site; other site 351581002447 Zn-binding sites [ion binding]; other site 351581002448 transaldolase-like protein; Provisional; Region: PTZ00411 351581002449 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 351581002450 active site 351581002451 dimer interface [polypeptide binding]; other site 351581002452 catalytic residue [active] 351581002453 Isochorismatase family; Region: Isochorismatase; pfam00857 351581002454 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 351581002455 catalytic triad [active] 351581002456 conserved cis-peptide bond; other site 351581002457 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 351581002458 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 351581002459 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 351581002460 Part of AAA domain; Region: AAA_19; pfam13245 351581002461 Family description; Region: UvrD_C_2; pfam13538 351581002462 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 351581002463 S1 domain; Region: S1_2; pfam13509 351581002464 S1 domain; Region: S1_2; pfam13509 351581002465 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 351581002466 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 351581002467 active site residue [active] 351581002468 recombination associated protein; Reviewed; Region: rdgC; PRK00321 351581002469 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 351581002470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 351581002471 non-specific DNA binding site [nucleotide binding]; other site 351581002472 salt bridge; other site 351581002473 sequence-specific DNA binding site [nucleotide binding]; other site 351581002474 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 351581002475 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 351581002476 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 351581002477 active site 351581002478 dimerization interface [polypeptide binding]; other site 351581002479 Predicted membrane protein [Function unknown]; Region: COG2855 351581002480 putative transporter; Provisional; Region: PRK03699 351581002481 Uncharacterized conserved protein [Function unknown]; Region: COG4121 351581002482 YCII-related domain; Region: YCII; cl00999 351581002483 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 351581002484 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 351581002485 dimer interface [polypeptide binding]; other site 351581002486 active site 351581002487 acyl carrier protein; Provisional; Region: acpP; PRK00982 351581002488 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 351581002489 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 351581002490 NAD(P) binding site [chemical binding]; other site 351581002491 homotetramer interface [polypeptide binding]; other site 351581002492 homodimer interface [polypeptide binding]; other site 351581002493 active site 351581002494 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 351581002495 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 351581002496 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 351581002497 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 351581002498 dimer interface [polypeptide binding]; other site 351581002499 active site 351581002500 CoA binding pocket [chemical binding]; other site 351581002501 putative phosphate acyltransferase; Provisional; Region: PRK05331 351581002502 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 351581002503 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 351581002504 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 351581002505 TPP-binding site [chemical binding]; other site 351581002506 dimer interface [polypeptide binding]; other site 351581002507 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 351581002508 PYR/PP interface [polypeptide binding]; other site 351581002509 dimer interface [polypeptide binding]; other site 351581002510 TPP binding site [chemical binding]; other site 351581002511 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 351581002512 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 351581002513 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 351581002514 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 351581002515 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 351581002516 Phosphoglycerate kinase; Region: PGK; pfam00162 351581002517 substrate binding site [chemical binding]; other site 351581002518 hinge regions; other site 351581002519 ADP binding site [chemical binding]; other site 351581002520 catalytic site [active] 351581002521 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 351581002522 pyruvate kinase; Provisional; Region: PRK05826 351581002523 domain interfaces; other site 351581002524 active site 351581002525 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 351581002526 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 351581002527 intersubunit interface [polypeptide binding]; other site 351581002528 active site 351581002529 zinc binding site [ion binding]; other site 351581002530 Na+ binding site [ion binding]; other site 351581002531 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 351581002532 Protein of unknown function (DUF877); Region: DUF877; pfam05943 351581002533 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 351581002534 Intracellular growth locus C protein; Region: IglC; pfam11550 351581002535 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 351581002536 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 351581002537 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 351581002538 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 351581002539 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 351581002540 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 351581002541 dimer interface [polypeptide binding]; other site 351581002542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351581002543 catalytic residue [active] 351581002544 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 351581002545 active site 351581002546 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 351581002547 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 351581002548 trmE is a tRNA modification GTPase; Region: trmE; cd04164 351581002549 G1 box; other site 351581002550 GTP/Mg2+ binding site [chemical binding]; other site 351581002551 Switch I region; other site 351581002552 G2 box; other site 351581002553 Switch II region; other site 351581002554 G3 box; other site 351581002555 G4 box; other site 351581002556 G5 box; other site 351581002557 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 351581002558 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 351581002559 30S subunit binding site; other site 351581002560 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 351581002561 active site 351581002562 phosphorylation site [posttranslational modification] 351581002563 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 351581002564 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 351581002565 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 351581002566 RNA/DNA hybrid binding site [nucleotide binding]; other site 351581002567 active site 351581002568 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 351581002569 Na binding site [ion binding]; other site 351581002570 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 351581002571 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 351581002572 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 351581002573 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 351581002574 23S rRNA interface [nucleotide binding]; other site 351581002575 L3 interface [polypeptide binding]; other site 351581002576 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 351581002577 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 351581002578 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 351581002579 MltA specific insert domain; Region: MltA; smart00925 351581002580 3D domain; Region: 3D; pfam06725 351581002581 GrpE; Region: GrpE; pfam01025 351581002582 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 351581002583 dimer interface [polypeptide binding]; other site 351581002584 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 351581002585 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 351581002586 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 351581002587 nucleotide binding site [chemical binding]; other site 351581002588 chaperone protein DnaJ; Provisional; Region: PRK10767 351581002589 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 351581002590 HSP70 interaction site [polypeptide binding]; other site 351581002591 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 351581002592 substrate binding site [polypeptide binding]; other site 351581002593 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 351581002594 Zn binding sites [ion binding]; other site 351581002595 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 351581002596 dimer interface [polypeptide binding]; other site 351581002597 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 351581002598 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 351581002599 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 351581002600 dimer interface [polypeptide binding]; other site 351581002601 motif 1; other site 351581002602 active site 351581002603 motif 2; other site 351581002604 motif 3; other site 351581002605 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 351581002606 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 351581002607 putative tRNA-binding site [nucleotide binding]; other site 351581002608 B3/4 domain; Region: B3_4; pfam03483 351581002609 tRNA synthetase B5 domain; Region: B5; smart00874 351581002610 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 351581002611 dimer interface [polypeptide binding]; other site 351581002612 motif 1; other site 351581002613 motif 3; other site 351581002614 motif 2; other site 351581002615 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 351581002616 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 351581002617 metal binding site 2 [ion binding]; metal-binding site 351581002618 putative DNA binding helix; other site 351581002619 metal binding site 1 [ion binding]; metal-binding site 351581002620 dimer interface [polypeptide binding]; other site 351581002621 structural Zn2+ binding site [ion binding]; other site 351581002622 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 351581002623 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 351581002624 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 351581002625 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 351581002626 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 351581002627 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 351581002628 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 351581002629 putative active site [active] 351581002630 catalytic site [active] 351581002631 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 351581002632 putative active site [active] 351581002633 catalytic site [active] 351581002634 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 351581002635 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 351581002636 putative active site [active] 351581002637 catalytic site [active] 351581002638 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 351581002639 putative active site [active] 351581002640 catalytic site [active] 351581002641 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 351581002642 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 351581002643 Walker A motif; other site 351581002644 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 351581002645 trimer interface [polypeptide binding]; other site 351581002646 active site 351581002647 Lipopolysaccharide-assembly; Region: LptE; cl01125 351581002648 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 351581002649 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 351581002650 HIGH motif; other site 351581002651 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 351581002652 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 351581002653 active site 351581002654 KMSKS motif; other site 351581002655 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 351581002656 tRNA binding surface [nucleotide binding]; other site 351581002657 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 351581002658 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 351581002659 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 351581002660 Transglutaminase/protease-like homologues; Region: TGc; smart00460 351581002661 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 351581002662 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 351581002663 hypothetical protein; Provisional; Region: PRK07505 351581002664 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 351581002665 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351581002666 catalytic residue [active] 351581002667 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 351581002668 Transcriptional regulators [Transcription]; Region: MarR; COG1846 351581002669 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 351581002670 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 351581002671 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 351581002672 catalytic residues [active] 351581002673 FeS assembly protein SufD; Region: sufD; TIGR01981 351581002674 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 351581002675 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 351581002676 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 351581002677 Walker A/P-loop; other site 351581002678 ATP binding site [chemical binding]; other site 351581002679 Q-loop/lid; other site 351581002680 ABC transporter signature motif; other site 351581002681 Walker B; other site 351581002682 D-loop; other site 351581002683 H-loop/switch region; other site 351581002684 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 351581002685 putative ABC transporter; Region: ycf24; CHL00085 351581002686 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 351581002687 Transcriptional regulator; Region: Rrf2; pfam02082 351581002688 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 351581002689 TrkA-N domain; Region: TrkA_N; pfam02254 351581002690 TrkA-N domain; Region: TrkA_N; pfam02254 351581002691 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 351581002692 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 351581002693 rRNA binding site [nucleotide binding]; other site 351581002694 predicted 30S ribosome binding site; other site 351581002695 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 351581002696 signal recognition particle protein; Provisional; Region: PRK10867 351581002697 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 351581002698 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 351581002699 P loop; other site 351581002700 GTP binding site [chemical binding]; other site 351581002701 Signal peptide binding domain; Region: SRP_SPB; pfam02978 351581002702 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 351581002703 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 351581002704 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 351581002705 putative active site [active] 351581002706 putative catalytic site [active] 351581002707 putative DNA binding site [nucleotide binding]; other site 351581002708 putative phosphate binding site [ion binding]; other site 351581002709 metal binding site A [ion binding]; metal-binding site 351581002710 putative AP binding site [nucleotide binding]; other site 351581002711 putative metal binding site B [ion binding]; other site 351581002712 short chain dehydrogenase; Provisional; Region: PRK07577 351581002713 classical (c) SDRs; Region: SDR_c; cd05233 351581002714 NAD(P) binding site [chemical binding]; other site 351581002715 active site 351581002716 AAA domain; Region: AAA_17; pfam13207 351581002717 AAA domain; Region: AAA_18; pfam13238 351581002718 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 351581002719 glutathione reductase; Validated; Region: PRK06116 351581002720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 351581002721 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 351581002722 Uncharacterized conserved protein [Function unknown]; Region: COG0393 351581002723 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 351581002724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581002725 putative substrate translocation pore; other site 351581002726 POT family; Region: PTR2; cl17359 351581002727 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 351581002728 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 351581002729 ATP binding site [chemical binding]; other site 351581002730 Mg++ binding site [ion binding]; other site 351581002731 motif III; other site 351581002732 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351581002733 nucleotide binding region [chemical binding]; other site 351581002734 ATP-binding site [chemical binding]; other site 351581002735 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 351581002736 GTP cyclohydrolase I; Provisional; Region: PLN03044 351581002737 active site 351581002738 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 351581002739 Glutamine amidotransferase class-I; Region: GATase; pfam00117 351581002740 glutamine binding [chemical binding]; other site 351581002741 catalytic triad [active] 351581002742 aminodeoxychorismate synthase; Provisional; Region: PRK07508 351581002743 chorismate binding enzyme; Region: Chorismate_bind; cl10555 351581002744 Aminotransferase class IV; Region: Aminotran_4; pfam01063 351581002745 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 351581002746 substrate-cofactor binding pocket; other site 351581002747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351581002748 catalytic residue [active] 351581002749 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 351581002750 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 351581002751 acyl-activating enzyme (AAE) consensus motif; other site 351581002752 AMP binding site [chemical binding]; other site 351581002753 active site 351581002754 CoA binding site [chemical binding]; other site 351581002755 Dihydroneopterin aldolase; Region: FolB; smart00905 351581002756 active site 351581002757 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 351581002758 catalytic center binding site [active] 351581002759 ATP binding site [chemical binding]; other site 351581002760 dihydropteroate synthase; Region: DHPS; TIGR01496 351581002761 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 351581002762 substrate binding pocket [chemical binding]; other site 351581002763 dimer interface [polypeptide binding]; other site 351581002764 inhibitor binding site; inhibition site 351581002765 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 351581002766 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 351581002767 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 351581002768 active site 2 [active] 351581002769 active site 1 [active] 351581002770 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 351581002771 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 351581002772 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 351581002773 inhibitor-cofactor binding pocket; inhibition site 351581002774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351581002775 catalytic residue [active] 351581002776 biotin synthase; Region: bioB; TIGR00433 351581002777 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351581002778 FeS/SAM binding site; other site 351581002779 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 351581002780 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 351581002781 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 351581002782 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351581002783 catalytic residue [active] 351581002784 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 351581002785 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 351581002786 AAA domain; Region: AAA_26; pfam13500 351581002787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 351581002788 dimerization interface [polypeptide binding]; other site 351581002789 putative DNA binding site [nucleotide binding]; other site 351581002790 putative Zn2+ binding site [ion binding]; other site 351581002791 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 351581002792 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 351581002793 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 351581002794 nucleotide binding site [chemical binding]; other site 351581002795 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 351581002796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581002797 putative substrate translocation pore; other site 351581002798 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 351581002799 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 351581002800 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 351581002801 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 351581002802 inhibitor-cofactor binding pocket; inhibition site 351581002803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351581002804 catalytic residue [active] 351581002805 glutathione synthetase; Provisional; Region: PRK05246 351581002806 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 351581002807 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 351581002808 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 351581002809 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 351581002810 putative active site [active] 351581002811 substrate binding site [chemical binding]; other site 351581002812 putative cosubstrate binding site; other site 351581002813 catalytic site [active] 351581002814 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 351581002815 substrate binding site [chemical binding]; other site 351581002816 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 351581002817 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 351581002818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 351581002819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351581002820 S-adenosylmethionine binding site [chemical binding]; other site 351581002821 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 351581002822 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 351581002823 active site 351581002824 nucleic acid binding site [nucleotide binding]; other site 351581002825 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 351581002826 short chain dehydrogenase; Provisional; Region: PRK05993 351581002827 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 351581002828 NADP binding site [chemical binding]; other site 351581002829 active site 351581002830 steroid binding site; other site 351581002831 SnoaL-like domain; Region: SnoaL_2; pfam12680 351581002832 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 351581002833 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 351581002834 ferredoxin-NADP reductase; Provisional; Region: PRK10926 351581002835 FAD binding pocket [chemical binding]; other site 351581002836 FAD binding motif [chemical binding]; other site 351581002837 phosphate binding motif [ion binding]; other site 351581002838 beta-alpha-beta structure motif; other site 351581002839 NAD binding pocket [chemical binding]; other site 351581002840 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 351581002841 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 351581002842 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 351581002843 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 351581002844 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 351581002845 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 351581002846 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 351581002847 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 351581002848 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 351581002849 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 351581002850 active site 351581002851 multimer interface [polypeptide binding]; other site 351581002852 CTP synthetase; Validated; Region: pyrG; PRK05380 351581002853 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 351581002854 Catalytic site [active] 351581002855 active site 351581002856 UTP binding site [chemical binding]; other site 351581002857 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 351581002858 active site 351581002859 putative oxyanion hole; other site 351581002860 catalytic triad [active] 351581002861 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 351581002862 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 351581002863 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 351581002864 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 351581002865 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 351581002866 ligand binding site [chemical binding]; other site 351581002867 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 351581002868 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 351581002869 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 351581002870 active site 351581002871 (T/H)XGH motif; other site 351581002872 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 351581002873 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 351581002874 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 351581002875 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 351581002876 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351581002877 catalytic residue [active] 351581002878 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 351581002879 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 351581002880 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 351581002881 Protein of unknown function DUF45; Region: DUF45; pfam01863 351581002882 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 351581002883 Prephenate dehydratase; Region: PDT; pfam00800 351581002884 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 351581002885 putative L-Phe binding site [chemical binding]; other site 351581002886 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 351581002887 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 351581002888 active site 351581002889 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 351581002890 dimer interface [polypeptide binding]; other site 351581002891 substrate binding site [chemical binding]; other site 351581002892 catalytic residues [active] 351581002893 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 351581002894 POT family; Region: PTR2; cl17359 351581002895 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 351581002896 putative C-terminal domain interface [polypeptide binding]; other site 351581002897 putative GSH binding site [chemical binding]; other site 351581002898 putative dimer interface [polypeptide binding]; other site 351581002899 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 351581002900 dimer interface [polypeptide binding]; other site 351581002901 substrate binding pocket (H-site) [chemical binding]; other site 351581002902 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 351581002903 putative N-terminal domain interface [polypeptide binding]; other site 351581002904 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 351581002905 hypothetical protein; Provisional; Region: PRK14013 351581002906 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 351581002907 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 351581002908 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 351581002909 active site 351581002910 recombination protein F; Reviewed; Region: recF; PRK00064 351581002911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351581002912 Walker A/P-loop; other site 351581002913 ATP binding site [chemical binding]; other site 351581002914 Q-loop/lid; other site 351581002915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351581002916 ABC transporter signature motif; other site 351581002917 Walker B; other site 351581002918 D-loop; other site 351581002919 H-loop/switch region; other site 351581002920 EamA-like transporter family; Region: EamA; pfam00892 351581002921 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 351581002922 EamA-like transporter family; Region: EamA; pfam00892 351581002923 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 351581002924 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 351581002925 active site 351581002926 tetramer interface; other site 351581002927 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 351581002928 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 351581002929 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 351581002930 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 351581002931 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 351581002932 DNA-binding site [nucleotide binding]; DNA binding site 351581002933 RNA-binding motif; other site 351581002934 Radical SAM superfamily; Region: Radical_SAM; pfam04055 351581002935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351581002936 FeS/SAM binding site; other site 351581002937 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 351581002938 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 351581002939 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 351581002940 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 351581002941 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 351581002942 non-specific DNA interactions [nucleotide binding]; other site 351581002943 DNA binding site [nucleotide binding] 351581002944 sequence specific DNA binding site [nucleotide binding]; other site 351581002945 putative cAMP binding site [chemical binding]; other site 351581002946 Bacterial transcriptional regulator; Region: IclR; pfam01614 351581002947 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 351581002948 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351581002949 RNA binding surface [nucleotide binding]; other site 351581002950 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 351581002951 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 351581002952 putative substrate binding site [chemical binding]; other site 351581002953 putative ATP binding site [chemical binding]; other site 351581002954 Putative serine esterase (DUF676); Region: DUF676; pfam05057 351581002955 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 351581002956 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 351581002957 catalytic residues [active] 351581002958 dimer interface [polypeptide binding]; other site 351581002959 Chorismate mutase type II; Region: CM_2; smart00830 351581002960 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 351581002961 L-aspartate oxidase; Provisional; Region: PRK06175 351581002962 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 351581002963 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 351581002964 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 351581002965 dimerization interface [polypeptide binding]; other site 351581002966 active site 351581002967 quinolinate synthetase; Provisional; Region: PRK09375 351581002968 Guanylate kinase; Region: Guanylate_kin; pfam00625 351581002969 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 351581002970 catalytic site [active] 351581002971 G-X2-G-X-G-K; other site 351581002972 helicase 45; Provisional; Region: PTZ00424 351581002973 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 351581002974 ATP binding site [chemical binding]; other site 351581002975 Mg++ binding site [ion binding]; other site 351581002976 motif III; other site 351581002977 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 351581002978 nucleotide binding region [chemical binding]; other site 351581002979 ATP-binding site [chemical binding]; other site 351581002980 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 351581002981 putative RNA binding site [nucleotide binding]; other site 351581002982 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 351581002983 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 351581002984 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 351581002985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581002986 putative substrate translocation pore; other site 351581002987 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 351581002988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581002989 putative substrate translocation pore; other site 351581002990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581002991 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 351581002992 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 351581002993 dimer interface [polypeptide binding]; other site 351581002994 active site 351581002995 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 351581002996 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 351581002997 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 351581002998 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 351581002999 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 351581003000 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 351581003001 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 351581003002 Ligand binding site; other site 351581003003 oligomer interface; other site 351581003004 Uncharacterized conserved protein [Function unknown]; Region: COG2835 351581003005 Uncharacterized conserved protein [Function unknown]; Region: COG0398 351581003006 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 351581003007 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 351581003008 23S rRNA binding site [nucleotide binding]; other site 351581003009 L21 binding site [polypeptide binding]; other site 351581003010 L13 binding site [polypeptide binding]; other site 351581003011 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 351581003012 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 351581003013 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 351581003014 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 351581003015 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 351581003016 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 351581003017 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 351581003018 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 351581003019 active site 351581003020 dimer interface [polypeptide binding]; other site 351581003021 motif 1; other site 351581003022 motif 2; other site 351581003023 motif 3; other site 351581003024 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 351581003025 anticodon binding site; other site 351581003026 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 351581003027 lipoyl attachment site [posttranslational modification]; other site 351581003028 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 351581003029 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 351581003030 homodimer interface [polypeptide binding]; other site 351581003031 active site 351581003032 hypothetical protein; Validated; Region: PRK00153 351581003033 recombination protein RecR; Provisional; Region: PRK13844 351581003034 RecR protein; Region: RecR; pfam02132 351581003035 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 351581003036 putative active site [active] 351581003037 putative metal-binding site [ion binding]; other site 351581003038 tetramer interface [polypeptide binding]; other site 351581003039 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 351581003040 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 351581003041 Zn2+ binding site [ion binding]; other site 351581003042 Mg2+ binding site [ion binding]; other site 351581003043 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 351581003044 synthetase active site [active] 351581003045 NTP binding site [chemical binding]; other site 351581003046 metal binding site [ion binding]; metal-binding site 351581003047 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 351581003048 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 351581003049 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 351581003050 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 351581003051 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 351581003052 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 351581003053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003054 metabolite-proton symporter; Region: 2A0106; TIGR00883 351581003055 putative substrate translocation pore; other site 351581003056 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 351581003057 catalytic nucleophile [active] 351581003058 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 351581003059 proposed catalytic triad [active] 351581003060 active site nucleophile [active] 351581003061 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 351581003062 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 351581003063 substrate binding site [chemical binding]; other site 351581003064 ATP binding site [chemical binding]; other site 351581003065 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 351581003066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351581003067 motif II; other site 351581003068 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 351581003069 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 351581003070 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 351581003071 active site 351581003072 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 351581003073 active site 351581003074 LicD family; Region: LicD; pfam04991 351581003075 Methyltransferase domain; Region: Methyltransf_23; pfam13489 351581003076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351581003077 S-adenosylmethionine binding site [chemical binding]; other site 351581003078 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 351581003079 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 351581003080 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 351581003081 active site 351581003082 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 351581003083 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 351581003084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351581003085 Walker A/P-loop; other site 351581003086 ATP binding site [chemical binding]; other site 351581003087 Q-loop/lid; other site 351581003088 ABC transporter signature motif; other site 351581003089 Walker B; other site 351581003090 D-loop; other site 351581003091 H-loop/switch region; other site 351581003092 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 351581003093 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 351581003094 putative ADP-binding pocket [chemical binding]; other site 351581003095 UDP-glucose 4-epimerase; Region: PLN02240 351581003096 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 351581003097 NAD binding site [chemical binding]; other site 351581003098 homodimer interface [polypeptide binding]; other site 351581003099 active site 351581003100 substrate binding site [chemical binding]; other site 351581003101 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 351581003102 Bacterial sugar transferase; Region: Bac_transf; pfam02397 351581003103 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 351581003104 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 351581003105 substrate binding site [chemical binding]; other site 351581003106 hexamer interface [polypeptide binding]; other site 351581003107 metal binding site [ion binding]; metal-binding site 351581003108 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 351581003109 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 351581003110 putative active site [active] 351581003111 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 351581003112 DoxX; Region: DoxX; pfam07681 351581003113 hypothetical protein; Provisional; Region: PRK05409 351581003114 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 351581003115 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 351581003116 NAD binding site [chemical binding]; other site 351581003117 homotetramer interface [polypeptide binding]; other site 351581003118 homodimer interface [polypeptide binding]; other site 351581003119 substrate binding site [chemical binding]; other site 351581003120 active site 351581003121 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 351581003122 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 351581003123 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 351581003124 GIY-YIG motif/motif A; other site 351581003125 active site 351581003126 catalytic site [active] 351581003127 putative DNA binding site [nucleotide binding]; other site 351581003128 metal binding site [ion binding]; metal-binding site 351581003129 UvrB/uvrC motif; Region: UVR; pfam02151 351581003130 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 351581003131 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 351581003132 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 351581003133 catalytic site [active] 351581003134 putative active site [active] 351581003135 putative substrate binding site [chemical binding]; other site 351581003136 HRDC domain; Region: HRDC; pfam00570 351581003137 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 351581003138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003139 putative substrate translocation pore; other site 351581003140 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 351581003141 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 351581003142 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 351581003143 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 351581003144 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351581003145 ATP binding site [chemical binding]; other site 351581003146 putative Mg++ binding site [ion binding]; other site 351581003147 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 351581003148 SEC-C motif; Region: SEC-C; pfam02810 351581003149 LPP20 lipoprotein; Region: LPP20; cl15824 351581003150 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 351581003151 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 351581003152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351581003153 Walker A motif; other site 351581003154 ATP binding site [chemical binding]; other site 351581003155 Walker B motif; other site 351581003156 arginine finger; other site 351581003157 Peptidase family M41; Region: Peptidase_M41; pfam01434 351581003158 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 351581003159 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 351581003160 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 351581003161 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 351581003162 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 351581003163 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 351581003164 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 351581003165 Type II transport protein GspH; Region: GspH; pfam12019 351581003166 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 351581003167 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 351581003168 active site 351581003169 dimer interface [polypeptide binding]; other site 351581003170 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 351581003171 dimer interface [polypeptide binding]; other site 351581003172 active site 351581003173 Thiamine pyrophosphokinase; Region: TPK; cd07995 351581003174 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 351581003175 active site 351581003176 dimerization interface [polypeptide binding]; other site 351581003177 thiamine binding site [chemical binding]; other site 351581003178 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 351581003179 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 351581003180 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 351581003181 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 351581003182 active site 351581003183 multifunctional aminopeptidase A; Provisional; Region: PRK00913 351581003184 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 351581003185 interface (dimer of trimers) [polypeptide binding]; other site 351581003186 Substrate-binding/catalytic site; other site 351581003187 Zn-binding sites [ion binding]; other site 351581003188 Predicted permeases [General function prediction only]; Region: COG0795 351581003189 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 351581003190 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 351581003191 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 351581003192 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 351581003193 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 351581003194 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 351581003195 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 351581003196 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 351581003197 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 351581003198 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 351581003199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 351581003200 Predicted membrane protein [Function unknown]; Region: COG2860 351581003201 UPF0126 domain; Region: UPF0126; pfam03458 351581003202 UPF0126 domain; Region: UPF0126; pfam03458 351581003203 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 351581003204 active site 351581003205 dinuclear metal binding site [ion binding]; other site 351581003206 dimerization interface [polypeptide binding]; other site 351581003207 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 351581003208 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 351581003209 active site 351581003210 catalytic motif [active] 351581003211 Zn binding site [ion binding]; other site 351581003212 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 351581003213 FAD binding domain; Region: FAD_binding_4; pfam01565 351581003214 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 351581003215 phosphoglyceromutase; Provisional; Region: PRK05434 351581003216 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 351581003217 seryl-tRNA synthetase; Provisional; Region: PRK05431 351581003218 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 351581003219 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 351581003220 dimer interface [polypeptide binding]; other site 351581003221 active site 351581003222 motif 1; other site 351581003223 motif 2; other site 351581003224 motif 3; other site 351581003225 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 351581003226 ROK family; Region: ROK; pfam00480 351581003227 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 351581003228 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 351581003229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351581003230 Walker A/P-loop; other site 351581003231 ATP binding site [chemical binding]; other site 351581003232 Q-loop/lid; other site 351581003233 ABC transporter signature motif; other site 351581003234 Walker B; other site 351581003235 D-loop; other site 351581003236 H-loop/switch region; other site 351581003237 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 351581003238 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 351581003239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351581003240 Walker A/P-loop; other site 351581003241 ATP binding site [chemical binding]; other site 351581003242 Q-loop/lid; other site 351581003243 ABC transporter signature motif; other site 351581003244 Walker B; other site 351581003245 D-loop; other site 351581003246 H-loop/switch region; other site 351581003247 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 351581003248 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 351581003249 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 351581003250 homotrimer interaction site [polypeptide binding]; other site 351581003251 putative active site [active] 351581003252 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 351581003253 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 351581003254 Sulfate transporter family; Region: Sulfate_transp; pfam00916 351581003255 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 351581003256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003257 metabolite-proton symporter; Region: 2A0106; TIGR00883 351581003258 putative substrate translocation pore; other site 351581003259 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 351581003260 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 351581003261 Zn2+ binding site [ion binding]; other site 351581003262 Mg2+ binding site [ion binding]; other site 351581003263 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 351581003264 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 351581003265 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 351581003266 heme binding site [chemical binding]; other site 351581003267 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 351581003268 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 351581003269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003270 putative substrate translocation pore; other site 351581003271 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 351581003272 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 351581003273 active site 351581003274 catalytic site [active] 351581003275 metal binding site [ion binding]; metal-binding site 351581003276 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 351581003277 HlyD family secretion protein; Region: HlyD_3; pfam13437 351581003278 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 351581003279 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 351581003280 Walker A/P-loop; other site 351581003281 ATP binding site [chemical binding]; other site 351581003282 Q-loop/lid; other site 351581003283 ABC transporter signature motif; other site 351581003284 Walker B; other site 351581003285 D-loop; other site 351581003286 H-loop/switch region; other site 351581003287 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 351581003288 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 351581003289 putative substrate binding pocket [chemical binding]; other site 351581003290 trimer interface [polypeptide binding]; other site 351581003291 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351581003292 active site 351581003293 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 351581003294 Glyco_18 domain; Region: Glyco_18; smart00636 351581003295 active site 351581003296 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 351581003297 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 351581003298 aromatic chitin/cellulose binding site residues [chemical binding]; other site 351581003299 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 351581003300 aromatic chitin/cellulose binding site residues [chemical binding]; other site 351581003301 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 351581003302 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 351581003303 substrate-cofactor binding pocket; other site 351581003304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 351581003305 catalytic residue [active] 351581003306 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 351581003307 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 351581003308 NAD(P) binding site [chemical binding]; other site 351581003309 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 351581003310 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 351581003311 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 351581003312 substrate binding site; other site 351581003313 dimer interface; other site 351581003314 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 351581003315 Septum formation initiator; Region: DivIC; cl17659 351581003316 enolase; Provisional; Region: eno; PRK00077 351581003317 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 351581003318 dimer interface [polypeptide binding]; other site 351581003319 metal binding site [ion binding]; metal-binding site 351581003320 substrate binding pocket [chemical binding]; other site 351581003321 Major Facilitator Superfamily; Region: MFS_1; pfam07690 351581003322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003323 putative substrate translocation pore; other site 351581003324 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 351581003325 TRAM domain; Region: TRAM; pfam01938 351581003326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351581003327 S-adenosylmethionine binding site [chemical binding]; other site 351581003328 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 351581003329 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 351581003330 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 351581003331 ATP-binding site [chemical binding]; other site 351581003332 Sugar specificity; other site 351581003333 Pyrimidine base specificity; other site 351581003334 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 351581003335 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 351581003336 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 351581003337 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 351581003338 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 351581003339 oligomer interface [polypeptide binding]; other site 351581003340 RNA binding site [nucleotide binding]; other site 351581003341 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 351581003342 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 351581003343 RNase E interface [polypeptide binding]; other site 351581003344 trimer interface [polypeptide binding]; other site 351581003345 active site 351581003346 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 351581003347 putative nucleic acid binding region [nucleotide binding]; other site 351581003348 G-X-X-G motif; other site 351581003349 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 351581003350 RNA binding site [nucleotide binding]; other site 351581003351 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 351581003352 16S/18S rRNA binding site [nucleotide binding]; other site 351581003353 S13e-L30e interaction site [polypeptide binding]; other site 351581003354 25S rRNA binding site [nucleotide binding]; other site 351581003355 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 351581003356 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 351581003357 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 351581003358 Cell division protein FtsL; Region: FtsL; cl11433 351581003359 MraW methylase family; Region: Methyltransf_5; cl17771 351581003360 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 351581003361 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 351581003362 AMP-binding enzyme; Region: AMP-binding; pfam00501 351581003363 acyl-activating enzyme (AAE) consensus motif; other site 351581003364 putative AMP binding site [chemical binding]; other site 351581003365 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 351581003366 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 351581003367 DNA binding site [nucleotide binding] 351581003368 catalytic residue [active] 351581003369 H2TH interface [polypeptide binding]; other site 351581003370 putative catalytic residues [active] 351581003371 turnover-facilitating residue; other site 351581003372 intercalation triad [nucleotide binding]; other site 351581003373 8OG recognition residue [nucleotide binding]; other site 351581003374 putative reading head residues; other site 351581003375 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 351581003376 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 351581003377 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 351581003378 predicted active site [active] 351581003379 catalytic triad [active] 351581003380 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 351581003381 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 351581003382 active site 351581003383 multimer interface [polypeptide binding]; other site 351581003384 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 351581003385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351581003386 ATP binding site [chemical binding]; other site 351581003387 Mg2+ binding site [ion binding]; other site 351581003388 G-X-G motif; other site 351581003389 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 351581003390 anchoring element; other site 351581003391 dimer interface [polypeptide binding]; other site 351581003392 ATP binding site [chemical binding]; other site 351581003393 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 351581003394 active site 351581003395 putative metal-binding site [ion binding]; other site 351581003396 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 351581003397 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 351581003398 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 351581003399 FMN binding site [chemical binding]; other site 351581003400 active site 351581003401 catalytic residues [active] 351581003402 substrate binding site [chemical binding]; other site 351581003403 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 351581003404 TIGR03546 family protein; Region: TIGR03546 351581003405 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 351581003406 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 351581003407 CoA-ligase; Region: Ligase_CoA; pfam00549 351581003408 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 351581003409 CoA binding domain; Region: CoA_binding; smart00881 351581003410 CoA-ligase; Region: Ligase_CoA; pfam00549 351581003411 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 351581003412 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 351581003413 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 351581003414 MFS transport protein AraJ; Provisional; Region: PRK10091 351581003415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003416 putative substrate translocation pore; other site 351581003417 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351581003418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351581003419 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 351581003420 putative effector binding pocket; other site 351581003421 dimerization interface [polypeptide binding]; other site 351581003422 phosphoglycolate phosphatase; Provisional; Region: PRK13222 351581003423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 351581003424 motif II; other site 351581003425 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 351581003426 PLD-like domain; Region: PLDc_2; pfam13091 351581003427 putative active site [active] 351581003428 catalytic site [active] 351581003429 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 351581003430 PLD-like domain; Region: PLDc_2; pfam13091 351581003431 putative active site [active] 351581003432 putative catalytic site [active] 351581003433 thioredoxin reductase; Provisional; Region: PRK10262 351581003434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 351581003435 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 351581003436 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 351581003437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351581003438 ATP binding site [chemical binding]; other site 351581003439 Mg2+ binding site [ion binding]; other site 351581003440 G-X-G motif; other site 351581003441 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 351581003442 ATP binding site [chemical binding]; other site 351581003443 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 351581003444 Predicted GTPases [General function prediction only]; Region: COG1162 351581003445 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 351581003446 RNA binding site [nucleotide binding]; other site 351581003447 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 351581003448 GTPase/Zn-binding domain interface [polypeptide binding]; other site 351581003449 GTP/Mg2+ binding site [chemical binding]; other site 351581003450 G4 box; other site 351581003451 G5 box; other site 351581003452 G1 box; other site 351581003453 Switch I region; other site 351581003454 G2 box; other site 351581003455 G3 box; other site 351581003456 Switch II region; other site 351581003457 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 351581003458 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 351581003459 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 351581003460 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 351581003461 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 351581003462 Domain of unknown function DUF20; Region: UPF0118; pfam01594 351581003463 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 351581003464 DHH family; Region: DHH; pfam01368 351581003465 DHHA1 domain; Region: DHHA1; pfam02272 351581003466 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 351581003467 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 351581003468 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 351581003469 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 351581003470 motif 1; other site 351581003471 dimer interface [polypeptide binding]; other site 351581003472 active site 351581003473 motif 2; other site 351581003474 motif 3; other site 351581003475 Helix-turn-helix domain; Region: HTH_25; pfam13413 351581003476 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 351581003477 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 351581003478 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 351581003479 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 351581003480 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 351581003481 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 351581003482 carboxyltransferase (CT) interaction site; other site 351581003483 biotinylation site [posttranslational modification]; other site 351581003484 Dehydroquinase class II; Region: DHquinase_II; pfam01220 351581003485 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 351581003486 trimer interface [polypeptide binding]; other site 351581003487 active site 351581003488 dimer interface [polypeptide binding]; other site 351581003489 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 351581003490 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 351581003491 active site 351581003492 metal binding site [ion binding]; metal-binding site 351581003493 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 351581003494 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 351581003495 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 351581003496 SurA N-terminal domain; Region: SurA_N; pfam09312 351581003497 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 351581003498 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 351581003499 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 351581003500 Organic solvent tolerance protein; Region: OstA_C; pfam04453 351581003501 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 351581003502 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 351581003503 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 351581003504 active site 351581003505 HIGH motif; other site 351581003506 nucleotide binding site [chemical binding]; other site 351581003507 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 351581003508 KMSK motif region; other site 351581003509 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 351581003510 tRNA binding surface [nucleotide binding]; other site 351581003511 anticodon binding site; other site 351581003512 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 351581003513 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 351581003514 dimer interface [polypeptide binding]; other site 351581003515 active site 351581003516 Schiff base residues; other site 351581003517 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 351581003518 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 351581003519 DNA polymerase III subunit delta'; Validated; Region: PRK08485 351581003520 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 351581003521 putative inner membrane peptidase; Provisional; Region: PRK11778 351581003522 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 351581003523 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 351581003524 tandem repeat interface [polypeptide binding]; other site 351581003525 oligomer interface [polypeptide binding]; other site 351581003526 active site residues [active] 351581003527 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 351581003528 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 351581003529 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 351581003530 dimer interface [polypeptide binding]; other site 351581003531 N-terminal domain interface [polypeptide binding]; other site 351581003532 DsrC like protein; Region: DsrC; pfam04358 351581003533 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 351581003534 oxidative damage protection protein; Provisional; Region: PRK05408 351581003535 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 351581003536 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 351581003537 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 351581003538 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 351581003539 Ligand binding site; other site 351581003540 Putative Catalytic site; other site 351581003541 DXD motif; other site 351581003542 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 351581003543 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 351581003544 putative active site [active] 351581003545 YdjC motif; other site 351581003546 Mg binding site [ion binding]; other site 351581003547 putative homodimer interface [polypeptide binding]; other site 351581003548 cell division protein FtsW; Region: ftsW; TIGR02614 351581003549 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 351581003550 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 351581003551 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 351581003552 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 351581003553 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 351581003554 Mg++ binding site [ion binding]; other site 351581003555 putative catalytic motif [active] 351581003556 putative substrate binding site [chemical binding]; other site 351581003557 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 351581003558 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 351581003559 active site 351581003560 metal-binding site [ion binding] 351581003561 nucleotide-binding site [chemical binding]; other site 351581003562 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 351581003563 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 351581003564 active site 351581003565 HIGH motif; other site 351581003566 nucleotide binding site [chemical binding]; other site 351581003567 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 351581003568 KMSKS motif; other site 351581003569 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 351581003570 ABC transporter ATPase component; Reviewed; Region: PRK11147 351581003571 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 351581003572 Walker A/P-loop; other site 351581003573 ATP binding site [chemical binding]; other site 351581003574 Q-loop/lid; other site 351581003575 ABC transporter signature motif; other site 351581003576 Walker B; other site 351581003577 D-loop; other site 351581003578 H-loop/switch region; other site 351581003579 ABC transporter; Region: ABC_tran_2; pfam12848 351581003580 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 351581003581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003582 Major Facilitator Superfamily; Region: MFS_1; pfam07690 351581003583 putative substrate translocation pore; other site 351581003584 Predicted membrane protein [Function unknown]; Region: COG4129 351581003585 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 351581003586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003587 putative substrate translocation pore; other site 351581003588 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 351581003589 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 351581003590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 351581003591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 351581003592 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 351581003593 dimerization interface [polypeptide binding]; other site 351581003594 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 351581003595 aromatic chitin/cellulose binding site residues [chemical binding]; other site 351581003596 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 351581003597 aromatic chitin/cellulose binding site residues [chemical binding]; other site 351581003598 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 351581003599 active site 351581003600 VacJ like lipoprotein; Region: VacJ; cl01073 351581003601 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 351581003602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351581003603 S-adenosylmethionine binding site [chemical binding]; other site 351581003604 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 351581003605 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 351581003606 glycerol kinase; Provisional; Region: glpK; PRK00047 351581003607 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 351581003608 N- and C-terminal domain interface [polypeptide binding]; other site 351581003609 active site 351581003610 MgATP binding site [chemical binding]; other site 351581003611 catalytic site [active] 351581003612 metal binding site [ion binding]; metal-binding site 351581003613 glycerol binding site [chemical binding]; other site 351581003614 homotetramer interface [polypeptide binding]; other site 351581003615 homodimer interface [polypeptide binding]; other site 351581003616 FBP binding site [chemical binding]; other site 351581003617 protein IIAGlc interface [polypeptide binding]; other site 351581003618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003619 putative substrate translocation pore; other site 351581003620 Major Facilitator Superfamily; Region: MFS_1; pfam07690 351581003621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003622 Major Facilitator Superfamily; Region: MFS_1; pfam07690 351581003623 putative substrate translocation pore; other site 351581003624 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 351581003625 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 351581003626 Walker A/P-loop; other site 351581003627 ATP binding site [chemical binding]; other site 351581003628 Q-loop/lid; other site 351581003629 ABC transporter signature motif; other site 351581003630 Walker B; other site 351581003631 D-loop; other site 351581003632 H-loop/switch region; other site 351581003633 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 351581003634 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 351581003635 Part of AAA domain; Region: AAA_19; pfam13245 351581003636 Family description; Region: UvrD_C_2; pfam13538 351581003637 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 351581003638 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 351581003639 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 351581003640 GTP binding site [chemical binding]; other site 351581003641 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 351581003642 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 351581003643 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 351581003644 G1 box; other site 351581003645 putative GEF interaction site [polypeptide binding]; other site 351581003646 GTP/Mg2+ binding site [chemical binding]; other site 351581003647 Switch I region; other site 351581003648 G2 box; other site 351581003649 G3 box; other site 351581003650 Switch II region; other site 351581003651 G4 box; other site 351581003652 G5 box; other site 351581003653 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 351581003654 thymidylate kinase; Validated; Region: tmk; PRK00698 351581003655 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 351581003656 TMP-binding site; other site 351581003657 ATP-binding site [chemical binding]; other site 351581003658 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 351581003659 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 351581003660 Nucleoside recognition; Region: Gate; pfam07670 351581003661 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 351581003662 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 351581003663 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 351581003664 Nucleoside recognition; Region: Gate; pfam07670 351581003665 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 351581003666 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 351581003667 intersubunit interface [polypeptide binding]; other site 351581003668 active site 351581003669 catalytic residue [active] 351581003670 phosphopentomutase; Provisional; Region: PRK05362 351581003671 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 351581003672 pantothenate kinase; Reviewed; Region: PRK13324 351581003673 DNA polymerase I; Provisional; Region: PRK05755 351581003674 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 351581003675 active site 351581003676 metal binding site 1 [ion binding]; metal-binding site 351581003677 putative 5' ssDNA interaction site; other site 351581003678 metal binding site 3; metal-binding site 351581003679 metal binding site 2 [ion binding]; metal-binding site 351581003680 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 351581003681 putative DNA binding site [nucleotide binding]; other site 351581003682 putative metal binding site [ion binding]; other site 351581003683 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 351581003684 active site 351581003685 catalytic site [active] 351581003686 substrate binding site [chemical binding]; other site 351581003687 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 351581003688 active site 351581003689 DNA binding site [nucleotide binding] 351581003690 catalytic site [active] 351581003691 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 351581003692 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 351581003693 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 351581003694 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 351581003695 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 351581003696 Walker A/P-loop; other site 351581003697 ATP binding site [chemical binding]; other site 351581003698 Q-loop/lid; other site 351581003699 ABC transporter signature motif; other site 351581003700 Walker B; other site 351581003701 D-loop; other site 351581003702 H-loop/switch region; other site 351581003703 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 351581003704 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 351581003705 active site 351581003706 NTP binding site [chemical binding]; other site 351581003707 metal binding triad [ion binding]; metal-binding site 351581003708 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 351581003709 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 351581003710 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 351581003711 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 351581003712 HlyD family secretion protein; Region: HlyD_3; pfam13437 351581003713 multidrug efflux protein; Reviewed; Region: PRK09579 351581003714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003715 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 351581003716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003717 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 351581003718 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 351581003719 dimer interface [polypeptide binding]; other site 351581003720 catalytic triad [active] 351581003721 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 351581003722 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 351581003723 active site 351581003724 HIGH motif; other site 351581003725 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 351581003726 KMSKS motif; other site 351581003727 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 351581003728 tRNA binding surface [nucleotide binding]; other site 351581003729 anticodon binding site; other site 351581003730 HemK family putative methylases; Region: hemK_fam; TIGR00536 351581003731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351581003732 S-adenosylmethionine binding site [chemical binding]; other site 351581003733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003734 Major Facilitator Superfamily; Region: MFS_1; pfam07690 351581003735 putative substrate translocation pore; other site 351581003736 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 351581003737 Coenzyme A binding pocket [chemical binding]; other site 351581003738 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 351581003739 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 351581003740 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 351581003741 DXD motif; other site 351581003742 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 351581003743 Na binding site [ion binding]; other site 351581003744 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 351581003745 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 351581003746 putative active site [active] 351581003747 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 351581003748 lysine transporter; Provisional; Region: PRK10836 351581003749 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 351581003750 active site 351581003751 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 351581003752 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 351581003753 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 351581003754 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 351581003755 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 351581003756 Cation transport protein; Region: TrkH; cl17365 351581003757 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 351581003758 ProQ/FINO family; Region: ProQ; smart00945 351581003759 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 351581003760 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 351581003761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 351581003762 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 351581003763 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 351581003764 ring oligomerisation interface [polypeptide binding]; other site 351581003765 ATP/Mg binding site [chemical binding]; other site 351581003766 stacking interactions; other site 351581003767 hinge regions; other site 351581003768 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 351581003769 oligomerisation interface [polypeptide binding]; other site 351581003770 mobile loop; other site 351581003771 roof hairpin; other site 351581003772 Predicted membrane protein [Function unknown]; Region: COG4125 351581003773 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 351581003774 hypothetical protein; Validated; Region: PRK02101 351581003775 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 351581003776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 351581003777 peptide chain release factor 1; Validated; Region: prfA; PRK00591 351581003778 This domain is found in peptide chain release factors; Region: PCRF; smart00937 351581003779 RF-1 domain; Region: RF-1; pfam00472 351581003780 glutamyl-tRNA reductase; Provisional; Region: PRK13940 351581003781 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 351581003782 tRNA; other site 351581003783 putative tRNA binding site [nucleotide binding]; other site 351581003784 putative NADP binding site [chemical binding]; other site 351581003785 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 351581003786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 351581003787 TPR motif; other site 351581003788 binding surface 351581003789 Tetratricopeptide repeat; Region: TPR_16; pfam13432 351581003790 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 351581003791 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 351581003792 Trp docking motif [polypeptide binding]; other site 351581003793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003794 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 351581003795 putative substrate translocation pore; other site 351581003796 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 351581003797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351581003798 Mg2+ binding site [ion binding]; other site 351581003799 G-X-G motif; other site 351581003800 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 351581003801 anchoring element; other site 351581003802 dimer interface [polypeptide binding]; other site 351581003803 ATP binding site [chemical binding]; other site 351581003804 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 351581003805 active site 351581003806 metal binding site [ion binding]; metal-binding site 351581003807 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 351581003808 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 351581003809 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 351581003810 amidase catalytic site [active] 351581003811 Zn binding residues [ion binding]; other site 351581003812 substrate binding site [chemical binding]; other site 351581003813 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 351581003814 active site 351581003815 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 351581003816 putative active site [active] 351581003817 Ap4A binding site [chemical binding]; other site 351581003818 nudix motif; other site 351581003819 putative metal binding site [ion binding]; other site 351581003820 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 351581003821 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 351581003822 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 351581003823 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 351581003824 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 351581003825 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 351581003826 active site 351581003827 DNA binding site [nucleotide binding] 351581003828 Int/Topo IB signature motif; other site 351581003829 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 351581003830 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 351581003831 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 351581003832 RimM N-terminal domain; Region: RimM; pfam01782 351581003833 PRC-barrel domain; Region: PRC; pfam05239 351581003834 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 351581003835 S-adenosylmethionine synthetase; Validated; Region: PRK05250 351581003836 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 351581003837 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 351581003838 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 351581003839 Fatty acid desaturase; Region: FA_desaturase; pfam00487 351581003840 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 351581003841 Di-iron ligands [ion binding]; other site 351581003842 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 351581003843 UGMP family protein; Validated; Region: PRK09604 351581003844 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 351581003845 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 351581003846 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 351581003847 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 351581003848 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 351581003849 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 351581003850 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 351581003851 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 351581003852 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 351581003853 cleft; other site 351581003854 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 351581003855 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 351581003856 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 351581003857 DNA binding site [nucleotide binding] 351581003858 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 351581003859 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 351581003860 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 351581003861 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 351581003862 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 351581003863 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 351581003864 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 351581003865 RPB3 interaction site [polypeptide binding]; other site 351581003866 RPB1 interaction site [polypeptide binding]; other site 351581003867 RPB11 interaction site [polypeptide binding]; other site 351581003868 RPB10 interaction site [polypeptide binding]; other site 351581003869 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 351581003870 core dimer interface [polypeptide binding]; other site 351581003871 peripheral dimer interface [polypeptide binding]; other site 351581003872 L10 interface [polypeptide binding]; other site 351581003873 L11 interface [polypeptide binding]; other site 351581003874 putative EF-Tu interaction site [polypeptide binding]; other site 351581003875 putative EF-G interaction site [polypeptide binding]; other site 351581003876 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 351581003877 23S rRNA interface [nucleotide binding]; other site 351581003878 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 351581003879 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 351581003880 mRNA/rRNA interface [nucleotide binding]; other site 351581003881 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 351581003882 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 351581003883 23S rRNA interface [nucleotide binding]; other site 351581003884 L7/L12 interface [polypeptide binding]; other site 351581003885 putative thiostrepton binding site; other site 351581003886 L25 interface [polypeptide binding]; other site 351581003887 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 351581003888 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 351581003889 putative homodimer interface [polypeptide binding]; other site 351581003890 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 351581003891 heterodimer interface [polypeptide binding]; other site 351581003892 homodimer interface [polypeptide binding]; other site 351581003893 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 351581003894 elongation factor Tu; Reviewed; Region: PRK00049 351581003895 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 351581003896 G1 box; other site 351581003897 GEF interaction site [polypeptide binding]; other site 351581003898 GTP/Mg2+ binding site [chemical binding]; other site 351581003899 Switch I region; other site 351581003900 G2 box; other site 351581003901 G3 box; other site 351581003902 Switch II region; other site 351581003903 G4 box; other site 351581003904 G5 box; other site 351581003905 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 351581003906 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 351581003907 Antibiotic Binding Site [chemical binding]; other site 351581003908 Mechanosensitive ion channel; Region: MS_channel; pfam00924 351581003909 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 351581003910 amphipathic channel; other site 351581003911 Asn-Pro-Ala signature motifs; other site 351581003912 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 351581003913 ATP-grasp domain; Region: ATP-grasp_4; cl17255 351581003914 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 351581003915 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 351581003916 dimer interface [polypeptide binding]; other site 351581003917 phosphorylation site [posttranslational modification] 351581003918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 351581003919 ATP binding site [chemical binding]; other site 351581003920 Mg2+ binding site [ion binding]; other site 351581003921 G-X-G motif; other site 351581003922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 351581003923 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 351581003924 NAD(P) binding site [chemical binding]; other site 351581003925 active site 351581003926 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 351581003927 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 351581003928 aconitate hydratase; Validated; Region: PRK09277 351581003929 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 351581003930 substrate binding site [chemical binding]; other site 351581003931 ligand binding site [chemical binding]; other site 351581003932 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 351581003933 substrate binding site [chemical binding]; other site 351581003934 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 351581003935 Predicted membrane protein [Function unknown]; Region: COG2246 351581003936 GtrA-like protein; Region: GtrA; pfam04138 351581003937 HemN family oxidoreductase; Provisional; Region: PRK05660 351581003938 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 351581003939 FeS/SAM binding site; other site 351581003940 HemN C-terminal domain; Region: HemN_C; pfam06969 351581003941 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 351581003942 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 351581003943 Preprotein translocase SecG subunit; Region: SecG; pfam03840 351581003944 triosephosphate isomerase; Provisional; Region: PRK14567 351581003945 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 351581003946 substrate binding site [chemical binding]; other site 351581003947 dimer interface [polypeptide binding]; other site 351581003948 catalytic triad [active] 351581003949 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 351581003950 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 351581003951 active site 351581003952 substrate binding site [chemical binding]; other site 351581003953 metal binding site [ion binding]; metal-binding site 351581003954 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351581003955 active site 351581003956 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 351581003957 E3 interaction surface; other site 351581003958 lipoyl attachment site [posttranslational modification]; other site 351581003959 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 351581003960 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 351581003961 E3 interaction surface; other site 351581003962 lipoyl attachment site [posttranslational modification]; other site 351581003963 e3 binding domain; Region: E3_binding; pfam02817 351581003964 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 351581003965 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 351581003966 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 351581003967 TPP-binding site [chemical binding]; other site 351581003968 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 351581003969 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 351581003970 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 351581003971 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 351581003972 L-aspartate oxidase; Provisional; Region: PRK06175 351581003973 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 351581003974 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 351581003975 SdhC subunit interface [polypeptide binding]; other site 351581003976 proximal heme binding site [chemical binding]; other site 351581003977 cardiolipin binding site; other site 351581003978 Iron-sulfur protein interface; other site 351581003979 proximal quinone binding site [chemical binding]; other site 351581003980 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 351581003981 Iron-sulfur protein interface; other site 351581003982 proximal quinone binding site [chemical binding]; other site 351581003983 SdhD (CybS) interface [polypeptide binding]; other site 351581003984 proximal heme binding site [chemical binding]; other site 351581003985 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 351581003986 dimer interface [polypeptide binding]; other site 351581003987 Citrate synthase; Region: Citrate_synt; pfam00285 351581003988 active site 351581003989 citrylCoA binding site [chemical binding]; other site 351581003990 NADH binding [chemical binding]; other site 351581003991 cationic pore residues; other site 351581003992 oxalacetate/citrate binding site [chemical binding]; other site 351581003993 coenzyme A binding site [chemical binding]; other site 351581003994 catalytic triad [active] 351581003995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581003996 muropeptide transporter; Reviewed; Region: ampG; PRK11902 351581003997 putative substrate translocation pore; other site 351581003998 superoxide dismutase; Provisional; Region: PRK10543 351581003999 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 351581004000 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 351581004001 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 351581004002 putative GSH binding site [chemical binding]; other site 351581004003 catalytic residues [active] 351581004004 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 351581004005 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 351581004006 putative active site [active] 351581004007 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 351581004008 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 351581004009 gamma subunit interface [polypeptide binding]; other site 351581004010 epsilon subunit interface [polypeptide binding]; other site 351581004011 LBP interface [polypeptide binding]; other site 351581004012 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 351581004013 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 351581004014 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 351581004015 alpha subunit interaction interface [polypeptide binding]; other site 351581004016 Walker A motif; other site 351581004017 ATP binding site [chemical binding]; other site 351581004018 Walker B motif; other site 351581004019 inhibitor binding site; inhibition site 351581004020 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 351581004021 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 351581004022 core domain interface [polypeptide binding]; other site 351581004023 delta subunit interface [polypeptide binding]; other site 351581004024 epsilon subunit interface [polypeptide binding]; other site 351581004025 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 351581004026 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 351581004027 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 351581004028 beta subunit interaction interface [polypeptide binding]; other site 351581004029 Walker A motif; other site 351581004030 ATP binding site [chemical binding]; other site 351581004031 Walker B motif; other site 351581004032 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 351581004033 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 351581004034 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 351581004035 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 351581004036 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 351581004037 F0F1 ATP synthase subunit C; Provisional; Region: PRK13464 351581004038 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 351581004039 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 351581004040 Major Facilitator Superfamily; Region: MFS_1; pfam07690 351581004041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581004042 putative substrate translocation pore; other site 351581004043 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 351581004044 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 351581004045 RNA binding surface [nucleotide binding]; other site 351581004046 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 351581004047 active site 351581004048 Predicted ATPase [General function prediction only]; Region: COG1485 351581004049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581004050 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 351581004051 putative substrate translocation pore; other site 351581004052 histidyl-tRNA synthetase; Region: hisS; TIGR00442 351581004053 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 351581004054 dimer interface [polypeptide binding]; other site 351581004055 motif 1; other site 351581004056 active site 351581004057 motif 2; other site 351581004058 motif 3; other site 351581004059 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 351581004060 anticodon binding site; other site 351581004061 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 351581004062 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 351581004063 translation initiation factor IF-2; Region: IF-2; TIGR00487 351581004064 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 351581004065 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 351581004066 G1 box; other site 351581004067 putative GEF interaction site [polypeptide binding]; other site 351581004068 GTP/Mg2+ binding site [chemical binding]; other site 351581004069 Switch I region; other site 351581004070 G2 box; other site 351581004071 G3 box; other site 351581004072 Switch II region; other site 351581004073 G4 box; other site 351581004074 G5 box; other site 351581004075 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 351581004076 Translation-initiation factor 2; Region: IF-2; pfam11987 351581004077 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 351581004078 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 351581004079 NusA N-terminal domain; Region: NusA_N; pfam08529 351581004080 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 351581004081 RNA binding site [nucleotide binding]; other site 351581004082 homodimer interface [polypeptide binding]; other site 351581004083 NusA-like KH domain; Region: KH_5; pfam13184 351581004084 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 351581004085 G-X-X-G motif; other site 351581004086 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 351581004087 ribosome maturation protein RimP; Reviewed; Region: PRK00092 351581004088 hypothetical protein; Provisional; Region: PRK14641 351581004089 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 351581004090 putative oligomer interface [polypeptide binding]; other site 351581004091 putative RNA binding site [nucleotide binding]; other site 351581004092 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 351581004093 substrate binding site [chemical binding]; other site 351581004094 active site 351581004095 Membrane fusogenic activity; Region: BMFP; pfam04380 351581004096 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 351581004097 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 351581004098 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 351581004099 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 351581004100 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 351581004101 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 351581004102 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 351581004103 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 351581004104 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 351581004105 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 351581004106 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 351581004107 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 351581004108 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 351581004109 NADH dehydrogenase subunit G; Validated; Region: PRK09129 351581004110 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 351581004111 catalytic loop [active] 351581004112 iron binding site [ion binding]; other site 351581004113 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 351581004114 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 351581004115 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 351581004116 SLBB domain; Region: SLBB; pfam10531 351581004117 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 351581004118 NADH dehydrogenase subunit E; Validated; Region: PRK07539 351581004119 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 351581004120 putative dimer interface [polypeptide binding]; other site 351581004121 [2Fe-2S] cluster binding site [ion binding]; other site 351581004122 NADH dehydrogenase subunit D; Validated; Region: PRK06075 351581004123 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 351581004124 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 351581004125 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 351581004126 NADH dehydrogenase subunit B; Validated; Region: PRK06411 351581004127 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 351581004128 ferric uptake regulator; Provisional; Region: fur; PRK09462 351581004129 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 351581004130 metal binding site 2 [ion binding]; metal-binding site 351581004131 putative DNA binding helix; other site 351581004132 metal binding site 1 [ion binding]; metal-binding site 351581004133 dimer interface [polypeptide binding]; other site 351581004134 structural Zn2+ binding site [ion binding]; other site 351581004135 IucA / IucC family; Region: IucA_IucC; pfam04183 351581004136 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 351581004137 Major Facilitator Superfamily; Region: MFS_1; pfam07690 351581004138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581004139 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 351581004140 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 351581004141 dimer interface [polypeptide binding]; other site 351581004142 active site 351581004143 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 351581004144 catalytic residues [active] 351581004145 substrate binding site [chemical binding]; other site 351581004146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581004147 putative substrate translocation pore; other site 351581004148 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 351581004149 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 351581004150 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 351581004151 GatB domain; Region: GatB_Yqey; smart00845 351581004152 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 351581004153 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 351581004154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 351581004155 adenylosuccinate lyase; Provisional; Region: PRK07492 351581004156 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 351581004157 tetramer interface [polypeptide binding]; other site 351581004158 active site 351581004159 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 351581004160 active site 351581004161 catalytic residues [active] 351581004162 NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521 351581004163 NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521 351581004164 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 351581004165 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 351581004166 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 351581004167 cofactor binding site; other site 351581004168 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 351581004169 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 351581004170 dimerization interface [polypeptide binding]; other site 351581004171 ATP binding site [chemical binding]; other site 351581004172 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 351581004173 dimerization interface [polypeptide binding]; other site 351581004174 ATP binding site [chemical binding]; other site 351581004175 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 351581004176 putative active site [active] 351581004177 catalytic triad [active] 351581004178 amidophosphoribosyltransferase; Provisional; Region: PRK09246 351581004179 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 351581004180 active site 351581004181 tetramer interface [polypeptide binding]; other site 351581004182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351581004183 active site 351581004184 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 351581004185 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 351581004186 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 351581004187 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 351581004188 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 351581004189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 351581004190 putative protease; Provisional; Region: PRK15452 351581004191 Peptidase family U32; Region: Peptidase_U32; pfam01136 351581004192 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 351581004193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581004194 putative substrate translocation pore; other site 351581004195 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 351581004196 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 351581004197 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 351581004198 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 351581004199 GTP1/OBG; Region: GTP1_OBG; pfam01018 351581004200 Obg GTPase; Region: Obg; cd01898 351581004201 G1 box; other site 351581004202 GTP/Mg2+ binding site [chemical binding]; other site 351581004203 Switch I region; other site 351581004204 G2 box; other site 351581004205 G3 box; other site 351581004206 Switch II region; other site 351581004207 G4 box; other site 351581004208 G5 box; other site 351581004209 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 351581004210 aromatic amino acid transport protein; Region: araaP; TIGR00837 351581004211 K+-transporting ATPase, c chain; Region: KdpC; cl00944 351581004212 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 351581004213 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 351581004214 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 351581004215 substrate binding site [chemical binding]; other site 351581004216 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 351581004217 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 351581004218 substrate binding site [chemical binding]; other site 351581004219 ligand binding site [chemical binding]; other site 351581004220 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 351581004221 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 351581004222 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 351581004223 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 351581004224 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 351581004225 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 351581004226 glutamine synthetase; Region: PLN02284 351581004227 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 351581004228 Eps15 homology domain; Region: EH; smart00027 351581004229 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 351581004230 Glutaminase; Region: Glutaminase; cl00907 351581004231 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 351581004232 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 351581004233 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 351581004234 hypothetical protein; Provisional; Region: PRK05208 351581004235 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 351581004236 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 351581004237 dimer interface [polypeptide binding]; other site 351581004238 putative anticodon binding site; other site 351581004239 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 351581004240 motif 1; other site 351581004241 active site 351581004242 motif 2; other site 351581004243 motif 3; other site 351581004244 This domain is found in peptide chain release factors; Region: PCRF; smart00937 351581004245 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 351581004246 RF-1 domain; Region: RF-1; pfam00472 351581004247 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 351581004248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 351581004249 Walker A motif; other site 351581004250 ATP binding site [chemical binding]; other site 351581004251 Walker B motif; other site 351581004252 DNA polymerase III subunit delta'; Validated; Region: PRK08485 351581004253 arginine finger; other site 351581004254 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 351581004255 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 351581004256 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 351581004257 cell division protein FtsZ; Validated; Region: PRK09330 351581004258 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 351581004259 nucleotide binding site [chemical binding]; other site 351581004260 SulA interaction site; other site 351581004261 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 351581004262 Cell division protein FtsA; Region: FtsA; smart00842 351581004263 Cell division protein FtsA; Region: FtsA; pfam14450 351581004264 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 351581004265 Cell division protein FtsQ; Region: FtsQ; pfam03799 351581004266 D-alanyl-alanine synthetase A; Provisional; Region: PRK14569 351581004267 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 351581004268 ATP-grasp domain; Region: ATP-grasp_4; cl17255 351581004269 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 351581004270 nucleoside/Zn binding site; other site 351581004271 dimer interface [polypeptide binding]; other site 351581004272 catalytic motif [active] 351581004273 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 351581004274 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 351581004275 RNA binding site [nucleotide binding]; other site 351581004276 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 351581004277 RNA binding site [nucleotide binding]; other site 351581004278 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 351581004279 RNA binding site [nucleotide binding]; other site 351581004280 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 351581004281 RNA binding site [nucleotide binding]; other site 351581004282 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 351581004283 RNA binding site [nucleotide binding]; other site 351581004284 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 351581004285 RNA binding site [nucleotide binding]; other site 351581004286 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 351581004287 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 351581004288 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 351581004289 putative acyl-acceptor binding pocket; other site 351581004290 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 351581004291 Competence protein; Region: Competence; pfam03772 351581004292 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 351581004293 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 351581004294 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 351581004295 Walker A/P-loop; other site 351581004296 ATP binding site [chemical binding]; other site 351581004297 Q-loop/lid; other site 351581004298 ABC transporter signature motif; other site 351581004299 Walker B; other site 351581004300 D-loop; other site 351581004301 H-loop/switch region; other site 351581004302 YGGT family; Region: YGGT; pfam02325 351581004303 YGGT family; Region: YGGT; pfam02325 351581004304 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 351581004305 putative active site [active] 351581004306 Zn binding site [ion binding]; other site 351581004307 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 351581004308 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 351581004309 purine monophosphate binding site [chemical binding]; other site 351581004310 dimer interface [polypeptide binding]; other site 351581004311 putative catalytic residues [active] 351581004312 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 351581004313 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 351581004314 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 351581004315 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 351581004316 GDP-binding site [chemical binding]; other site 351581004317 ACT binding site; other site 351581004318 IMP binding site; other site 351581004319 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 351581004320 active site 351581004321 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 351581004322 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 351581004323 dimer interface [polypeptide binding]; other site 351581004324 putative PBP binding regions; other site 351581004325 ABC-ATPase subunit interface; other site 351581004326 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 351581004327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351581004328 Walker A/P-loop; other site 351581004329 ATP binding site [chemical binding]; other site 351581004330 Q-loop/lid; other site 351581004331 ABC transporter signature motif; other site 351581004332 Walker B; other site 351581004333 D-loop; other site 351581004334 H-loop/switch region; other site 351581004335 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 351581004336 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 351581004337 intersubunit interface [polypeptide binding]; other site 351581004338 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 351581004339 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 351581004340 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 351581004341 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 351581004342 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 351581004343 primosome assembly protein PriA; Validated; Region: PRK05580 351581004344 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 351581004345 ATP binding site [chemical binding]; other site 351581004346 putative Mg++ binding site [ion binding]; other site 351581004347 helicase superfamily c-terminal domain; Region: HELICc; smart00490 351581004348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 351581004349 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 351581004350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 351581004351 Walker A/P-loop; other site 351581004352 ATP binding site [chemical binding]; other site 351581004353 Q-loop/lid; other site 351581004354 ABC transporter signature motif; other site 351581004355 Walker B; other site 351581004356 D-loop; other site 351581004357 H-loop/switch region; other site 351581004358 ABC transporter; Region: ABC_tran_2; pfam12848 351581004359 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 351581004360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 351581004361 metabolite-proton symporter; Region: 2A0106; TIGR00883 351581004362 putative substrate translocation pore; other site 351581004363 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 351581004364 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 351581004365 aminopeptidase N; Provisional; Region: pepN; PRK14015 351581004366 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 351581004367 active site 351581004368 Zn binding site [ion binding]; other site 351581004369 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 351581004370 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 351581004371 putative dimer interface [polypeptide binding]; other site 351581004372 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 351581004373 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 351581004374 active site 351581004375 ribulose/triose binding site [chemical binding]; other site 351581004376 phosphate binding site [ion binding]; other site 351581004377 substrate (anthranilate) binding pocket [chemical binding]; other site 351581004378 product (indole) binding pocket [chemical binding]; other site 351581004379 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 351581004380 active site 351581004381 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 351581004382 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 351581004383 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 351581004384 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 351581004385 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 351581004386 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 351581004387 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 351581004388 Glutamine amidotransferase class-I; Region: GATase; pfam00117 351581004389 glutamine binding [chemical binding]; other site 351581004390 catalytic triad [active] 351581004391 anthranilate synthase component I; Provisional; Region: PRK13564 351581004392 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 351581004393 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 351581004394 Trp repressor protein; Region: Trp_repressor; cl17266 351581004395 ribonuclease G; Provisional; Region: PRK11712 351581004396 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 351581004397 homodimer interface [polypeptide binding]; other site 351581004398 oligonucleotide binding site [chemical binding]; other site