-- dump date 20140619_095253 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_001427435.2 169656467 5524566 1..1476 1 NC_009749.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1476 dnaA 5524566 dnaA Francisella tularensis subsp. holarctica FTNF002-00 chromosomal replication initiation protein YP_001427435.2 1 D 458234 CDS YP_001427436.1 156501372 5524565 1513..2616 1 NC_009749.1 DNA polymerase III subunit beta 2616 dnaN 5524565 dnaN Francisella tularensis subsp. holarctica FTNF002-00 DNA polymerase III subunit beta YP_001427436.1 1513 D 458234 CDS YP_001427437.1 156501371 5524102 complement(2613..3050) 1 NC_009749.1 putative MFS transporter protein 3050 5524102 FTA_0002 Francisella tularensis subsp. holarctica FTNF002-00 putative MFS transporter protein YP_001427437.1 2613 R 458234 CDS YP_001427438.2 169656468 5524103 complement(join(3062..3613,3613..3942)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 3942 5524103 FTA_0004 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427438.2 3062 R 458234 CDS YP_001427443.1 156501378 5524381 complement(6630..6833) 1 NC_009749.1 hypothetical protein 6833 5524381 FTA_0009 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427443.1 6630 R 458234 CDS YP_001427444.2 169656469 5524382 6907..7830 1 NC_009749.1 S49 family peptidase 7830 5524382 FTA_0010 Francisella tularensis subsp. holarctica FTNF002-00 S49 family peptidase YP_001427444.2 6907 D 458234 CDS YP_001427445.1 156501380 5524383 7884..8459 1 NC_009749.1 Omp-H like outer membrane protein 8459 5524383 FTA_0011 Francisella tularensis subsp. holarctica FTNF002-00 Omp-H like outer membrane protein YP_001427445.1 7884 D 458234 CDS YP_001427446.1 156501381 5524385 8595..9017 1 NC_009749.1 rhodanese-like domain-containing protein 9017 5524385 FTA_0012 Francisella tularensis subsp. holarctica FTNF002-00 rhodanese-like domain-containing protein YP_001427446.1 8595 D 458234 CDS YP_001427447.1 156501382 5524384 9044..9493 1 NC_009749.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 9493 secB1 5524384 secB1 Francisella tularensis subsp. holarctica FTNF002-00 preprotein translocase subunit SecB YP_001427447.1 9044 D 458234 CDS YP_001427448.1 156501383 5522846 9515..10594 1 NC_009749.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 10594 recA 5522846 recA Francisella tularensis subsp. holarctica FTNF002-00 recombinase A YP_001427448.1 9515 D 458234 CDS YP_001427449.1 156501384 5522847 10581..11033 1 NC_009749.1 regulatory protein RecX 11033 recX 5522847 recX Francisella tularensis subsp. holarctica FTNF002-00 regulatory protein RecX YP_001427449.1 10581 D 458234 CDS YP_001427450.1 156501385 5522848 11206..11682 1 NC_009749.1 single-stranded DNA binding protein 11682 5522848 FTA_0016 Francisella tularensis subsp. holarctica FTNF002-00 single-stranded DNA binding protein YP_001427450.1 11206 D 458234 CDS YP_001427451.1 156501386 5522849 11788..12942 1 NC_009749.1 acetate kinase 12942 ackA 5522849 ackA Francisella tularensis subsp. holarctica FTNF002-00 acetate kinase YP_001427451.1 11788 D 458234 CDS YP_001427452.2 169656470 5522850 12952..15048 1 NC_009749.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 15048 5522850 FTA_0018 Francisella tularensis subsp. holarctica FTNF002-00 phosphate acetyltransferase YP_001427452.2 12952 D 458234 CDS YP_001427455.2 169656471 5522853 complement(join(15960..16511,16511..16840)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 16840 5522853 FTA_0020 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001427455.2 15960 R 458234 CDS YP_001427458.1 156501393 5522856 complement(17335..19107) 1 NC_009749.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 19107 aspS 5522856 aspS Francisella tularensis subsp. holarctica FTNF002-00 aspartyl-tRNA synthetase YP_001427458.1 17335 R 458234 CDS YP_001427459.1 156501394 5522858 complement(19281..20462) 1 NC_009749.1 major facilitator transporter 20462 5522858 FTA_0025 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001427459.1 19281 R 458234 CDS YP_001427462.2 169656472 5523318 join(21104..21433,21433..21984) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 21984 5523318 FTA_0028 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001427462.2 21104 D 458234 CDS YP_001715622.1 169656790 5983823 complement(22210..22380) 1 NC_009749.1 hypothetical protein 22380 5983823 FTA_2141 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001715622.1 22210 R 458234 CDS YP_001427465.1 156501400 5523322 complement(22931..24154) 1 NC_009749.1 amino acid transporter 24154 5523322 FTA_0031 Francisella tularensis subsp. holarctica FTNF002-00 amino acid transporter YP_001427465.1 22931 R 458234 CDS YP_001427466.1 156501401 5524332 complement(24481..24714) 1 NC_009749.1 hypothetical protein 24714 5524332 FTA_0032 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427466.1 24481 R 458234 CDS YP_001427469.1 156501404 5523325 complement(26097..27017) 1 NC_009749.1 aspartate carbamoyltransferase 27017 pyrB 5523325 pyrB Francisella tularensis subsp. holarctica FTNF002-00 aspartate carbamoyltransferase YP_001427469.1 26097 R 458234 CDS YP_001427470.1 156501405 5523326 complement(27159..30443) 1 NC_009749.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 30443 carB 5523326 carB Francisella tularensis subsp. holarctica FTNF002-00 carbamoyl phosphate synthase large subunit YP_001427470.1 27159 R 458234 CDS YP_001427471.1 156501406 5523327 complement(30448..31614) 1 NC_009749.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 31614 carA 5523327 carA Francisella tularensis subsp. holarctica FTNF002-00 carbamoyl phosphate synthase small subunit YP_001427471.1 30448 R 458234 CDS YP_001427472.1 156501407 5523329 32031..33086 1 NC_009749.1 acid phosphatase 33086 5523329 FTA_0038 Francisella tularensis subsp. holarctica FTNF002-00 acid phosphatase YP_001427472.1 32031 D 458234 CDS YP_001427473.1 156501408 5523328 complement(33210..33890) 1 NC_009749.1 catalyzes the S-adenosylmethionine-dependent transmethylation of thiopurine compounds; may be involved in selenium cycling by forming dimethylselenide and/or dimethyldiselenide; thiopurine S-methyltransferase 33890 5523328 FTA_0039 Francisella tularensis subsp. holarctica FTNF002-00 thiopurine S-methyltransferase YP_001427473.1 33210 R 458234 CDS YP_001427474.1 156501409 5523216 34022..35368 1 NC_009749.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; dihydroorotase 35368 pyrC 5523216 pyrC Francisella tularensis subsp. holarctica FTNF002-00 dihydroorotase YP_001427474.1 34022 D 458234 CDS YP_001427475.1 156501410 5523217 complement(35396..36436) 1 NC_009749.1 hypothetical protein 36436 5523217 FTA_0041 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427475.1 35396 R 458234 CDS YP_001427477.1 156501412 5523219 37640..38191 1 NC_009749.1 hypothetical protein 38191 5523219 FTA_0043 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427477.1 37640 D 458234 CDS YP_001427478.1 156501413 5523220 complement(38307..39359) 1 NC_009749.1 hypothetical protein 39359 5523220 FTA_0044 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427478.1 38307 R 458234 CDS YP_001427479.1 156501414 5523221 complement(39346..40311) 1 NC_009749.1 HlyD family secretion protein 40311 5523221 FTA_0045 Francisella tularensis subsp. holarctica FTNF002-00 HlyD family secretion protein YP_001427479.1 39346 R 458234 CDS YP_001427480.1 156501415 5523222 complement(40400..40807) 1 NC_009749.1 lipoprotein 40807 5523222 FTA_0046 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001427480.1 40400 R 458234 CDS YP_001427481.1 156501416 5523223 40933..41802 1 NC_009749.1 LysR family transcriptional regulator 41802 5523223 FTA_0047 Francisella tularensis subsp. holarctica FTNF002-00 LysR family transcriptional regulator YP_001427481.1 40933 D 458234 CDS YP_001427482.1 156501417 5523224 complement(41803..42174) 1 NC_009749.1 N-terminal truncation; SOUL heme-binding protein 42174 5523224 FTA_0048 Francisella tularensis subsp. holarctica FTNF002-00 SOUL heme-binding protein YP_001427482.1 41803 R 458234 CDS YP_001427483.1 156501419 5523225 42338..42475 1 NC_009749.1 hypothetical protein 42475 5523225 FTA_0050 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427483.1 42338 D 458234 CDS YP_001427484.1 156501418 5523228 complement(42464..43117) 1 NC_009749.1 transposase ISFTu2 43117 5523228 FTA_0049 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001427484.1 42464 R 458234 CDS YP_001427485.1 156501420 5523226 43429..43977 1 NC_009749.1 chorismate mutase 43977 5523226 FTA_0051 Francisella tularensis subsp. holarctica FTNF002-00 chorismate mutase YP_001427485.1 43429 D 458234 CDS YP_001427486.1 156501421 5523227 complement(44032..47265) 1 NC_009749.1 transglutaminase-like superfamily protein 47265 5523227 FTA_0052 Francisella tularensis subsp. holarctica FTNF002-00 transglutaminase-like superfamily protein YP_001427486.1 44032 R 458234 CDS YP_001427487.2 169656473 5524364 47685..48317 1 NC_009749.1 orotidine 5'-phosphate decarboxylase 48317 pyrF 5524364 pyrF Francisella tularensis subsp. holarctica FTNF002-00 orotidine 5'-phosphate decarboxylase YP_001427487.2 47685 D 458234 CDS YP_001427488.1 156501423 5524365 48307..49065 1 NC_009749.1 dihydroorotate dehydrogenase 49065 5524365 FTA_0054 Francisella tularensis subsp. holarctica FTNF002-00 dihydroorotate dehydrogenase YP_001427488.1 48307 D 458234 CDS YP_001427491.1 156501426 5524368 complement(50528..50965) 1 NC_009749.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 50965 dtd 5524368 dtd Francisella tularensis subsp. holarctica FTNF002-00 D-tyrosyl-tRNA(Tyr) deacylase YP_001427491.1 50528 R 458234 CDS YP_001427494.2 169656474 5524371 complement(52459..53883) 1 NC_009749.1 glycosyl hydrolase family protein 53883 5524371 FTA_0060 Francisella tularensis subsp. holarctica FTNF002-00 glycosyl hydrolase family protein YP_001427494.2 52459 R 458234 CDS YP_001427495.2 169656475 5524372 complement(join(54142..54693,54693..55022)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 55022 5524372 FTA_0061 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427495.2 54142 R 458234 CDS YP_001427497.2 169656476 5524374 complement(55046..55597) 1 NC_009749.1 hypothetical protein 55597 5524374 FTA_0063 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427497.2 55046 R 458234 CDS YP_001427498.1 156501433 5524376 complement(55868..56533) 1 NC_009749.1 nitroreductase family protein 56533 5524376 FTA_0064 Francisella tularensis subsp. holarctica FTNF002-00 nitroreductase family protein YP_001427498.1 55868 R 458234 CDS YP_001427499.1 156501435 5524375 56936..57628 1 NC_009749.1 contains DUF1275; hypothetical protein 57628 5524375 FTA_0066 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427499.1 56936 D 458234 CDS YP_001427500.1 156501434 5523462 complement(57625..58830) 1 NC_009749.1 tryptophan/tyrosine permease family protein 58830 5523462 FTA_0065 Francisella tularensis subsp. holarctica FTNF002-00 tryptophan/tyrosine permease family protein YP_001427500.1 57625 R 458234 CDS YP_001427501.1 156501436 5523464 58930..59547 1 NC_009749.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 59547 gidB 5523464 gidB Francisella tularensis subsp. holarctica FTNF002-00 16S rRNA methyltransferase GidB YP_001427501.1 58930 D 458234 CDS YP_001427502.1 156501438 5523463 59544..60212 1 NC_009749.1 hypothetical protein 60212 5523463 FTA_0069 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427502.1 59544 D 458234 CDS YP_001427503.1 156501437 5523465 complement(60205..61089) 1 NC_009749.1 hypothetical protein 61089 5523465 FTA_0068 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427503.1 60205 R 458234 CDS YP_001427504.1 156501439 5523467 complement(61291..61986) 1 NC_009749.1 LysR family transcriptional regulator 61986 5523467 FTA_0070 Francisella tularensis subsp. holarctica FTNF002-00 LysR family transcriptional regulator YP_001427504.1 61291 R 458234 CDS YP_001427505.1 156501440 5523466 62145..62276 1 NC_009749.1 hypothetical protein 62276 5523466 FTA_0071 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427505.1 62145 D 458234 CDS YP_001427506.1 156501441 5523468 62289..63425 1 NC_009749.1 major facilitator transporter 63425 5523468 FTA_0072 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001427506.1 62289 D 458234 CDS YP_001427510.1 156501445 5523472 65949..66545 1 NC_009749.1 phosphoheptose isomerase 66545 gmhA 5523472 gmhA Francisella tularensis subsp. holarctica FTNF002-00 phosphoheptose isomerase YP_001427510.1 65949 D 458234 CDS YP_001427511.1 156501446 5523474 66553..66909 1 NC_009749.1 Smp A/Oml family membrane lipoprotein 66909 5523474 FTA_0077 Francisella tularensis subsp. holarctica FTNF002-00 Smp A/Oml family membrane lipoprotein YP_001427511.1 66553 D 458234 CDS YP_001427512.1 156501447 5523473 complement(66983..67255) 1 NC_009749.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 67255 rpsT 5523473 rpsT Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S20 YP_001427512.1 66983 R 458234 CDS YP_001427513.1 156501448 5524580 67525..69309 1 NC_009749.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 69309 lepA 5524580 lepA Francisella tularensis subsp. holarctica FTNF002-00 GTP-binding protein LepA YP_001427513.1 67525 D 458234 CDS YP_001427514.1 156501449 5524581 69323..70402 1 NC_009749.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 70402 mnmA 5524581 mnmA Francisella tularensis subsp. holarctica FTNF002-00 tRNA-specific 2-thiouridylase MnmA YP_001427514.1 69323 D 458234 CDS YP_001427515.1 156501450 5524582 complement(70422..71414) 1 NC_009749.1 lipoprotein 71414 5524582 FTA_0081 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001427515.1 70422 R 458234 CDS YP_001427516.1 156501451 5524583 complement(71496..72020) 1 NC_009749.1 peptide deformylase 72020 def1 5524583 def1 Francisella tularensis subsp. holarctica FTNF002-00 peptide deformylase YP_001427516.1 71496 R 458234 CDS YP_001427517.1 156501452 5524584 complement(72017..72460) 1 NC_009749.1 6,7-dimethyl-8-ribityllumazine synthase 72460 ribH 5524584 ribH Francisella tularensis subsp. holarctica FTNF002-00 6,7-dimethyl-8-ribityllumazine synthase YP_001427517.1 72017 R 458234 CDS YP_001427518.1 156501453 5524585 complement(72470..73681) 1 NC_009749.1 bifunctional enzyme with 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II activities; bifunctional riboflavin biosynthesis protein 73681 ribAB 5524585 ribAB Francisella tularensis subsp. holarctica FTNF002-00 bifunctional riboflavin biosynthesis protein YP_001427518.1 72470 R 458234 CDS YP_001427519.1 156501454 5524586 complement(73674..74279) 1 NC_009749.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 74279 ribE 5524586 ribE Francisella tularensis subsp. holarctica FTNF002-00 riboflavin synthase subunit alpha YP_001427519.1 73674 R 458234 CDS YP_001427520.1 156501455 5524587 complement(74272..75339) 1 NC_009749.1 riboflavin biosynthesis protein 75339 ribD 5524587 ribD Francisella tularensis subsp. holarctica FTNF002-00 riboflavin biosynthesis protein YP_001427520.1 74272 R 458234 CDS YP_001427522.2 169656477 5524333 complement(join(76510..77010,77010..77339)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 77339 5524333 FTA_0088 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427522.2 76510 R 458234 CDS YP_001427524.1 156501459 5524591 complement(77583..78233) 1 NC_009749.1 major facilitator transporter 78233 5524591 FTA_0090 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001427524.1 77583 R 458234 CDS YP_001427525.1 156501460 5524592 complement(78312..78827) 1 NC_009749.1 B-type cytochrome subunit 78827 5524592 FTA_0091 Francisella tularensis subsp. holarctica FTNF002-00 B-type cytochrome subunit YP_001427525.1 78312 R 458234 CDS YP_001427528.1 156501463 5524388 79877..81028 1 NC_009749.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 81028 nhaA 5524388 nhaA Francisella tularensis subsp. holarctica FTNF002-00 pH-dependent sodium/proton antiporter YP_001427528.1 79877 D 458234 CDS YP_001427529.1 156501464 5524389 81093..81812 1 NC_009749.1 hypothetical protein 81812 5524389 FTA_0095 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427529.1 81093 D 458234 CDS YP_001427530.2 169656478 5524390 complement(81818..82558) 1 NC_009749.1 acetyltransferase 82558 5524390 FTA_0096 Francisella tularensis subsp. holarctica FTNF002-00 acetyltransferase YP_001427530.2 81818 R 458234 CDS YP_001427531.2 169656479 5524391 complement(82572..83324) 1 NC_009749.1 acetyltransferase 83324 5524391 FTA_0097 Francisella tularensis subsp. holarctica FTNF002-00 acetyltransferase YP_001427531.2 82572 R 458234 CDS YP_001427532.2 169656480 5524392 complement(83487..83810) 1 NC_009749.1 4Fe-4S ferredoxin 83810 5524392 FTA_0098 Francisella tularensis subsp. holarctica FTNF002-00 4Fe-4S ferredoxin YP_001427532.2 83487 R 458234 CDS YP_001427533.1 156501468 5524393 84042..84683 1 NC_009749.1 hypothetical protein 84683 5524393 FTA_0099 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427533.1 84042 D 458234 CDS YP_001427535.1 156501470 5524395 complement(85416..86576) 1 NC_009749.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 86576 purT 5524395 purT Francisella tularensis subsp. holarctica FTNF002-00 phosphoribosylglycinamide formyltransferase 2 YP_001427535.1 85416 R 458234 CDS YP_001427536.1 156501471 5524396 complement(86630..88822) 1 NC_009749.1 putative chitinase 88822 5524396 FTA_0102 Francisella tularensis subsp. holarctica FTNF002-00 putative chitinase YP_001427536.1 86630 R 458234 CDS YP_001427537.1 156501472 5524397 complement(89073..91652) 1 NC_009749.1 AAA ATPase 91652 5524397 FTA_0103 Francisella tularensis subsp. holarctica FTNF002-00 AAA ATPase YP_001427537.1 89073 R 458234 CDS YP_001427539.2 169656481 5524406 92598..92951 1 NC_009749.1 hypothetical protein 92951 5524406 FTA_0105 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427539.2 92598 D 458234 CDS YP_001427540.1 156501475 5524407 complement(93006..93815) 1 NC_009749.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 93815 trpA 5524407 trpA Francisella tularensis subsp. holarctica FTNF002-00 tryptophan synthase subunit alpha YP_001427540.1 93006 R 458234 CDS YP_001427541.1 156501476 5524408 complement(93815..95005) 1 NC_009749.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 95005 trpB 5524408 trpB Francisella tularensis subsp. holarctica FTNF002-00 tryptophan synthase subunit beta YP_001427541.1 93815 R 458234 CDS YP_001427542.2 169656482 5524409 complement(95092..96597) 1 NC_009749.1 M32 family metallocarboxypeptidase 96597 5524409 FTA_0108 Francisella tularensis subsp. holarctica FTNF002-00 M32 family metallocarboxypeptidase YP_001427542.2 95092 R 458234 CDS YP_001427543.2 169656483 5524410 complement(96533..97927) 1 NC_009749.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 97927 5524410 FTA_0109 Francisella tularensis subsp. holarctica FTNF002-00 chloride channel protein YP_001427543.2 96533 R 458234 CDS YP_001427545.1 156501480 5524412 complement(98422..98832) 1 NC_009749.1 hypothetical protein 98832 5524412 FTA_0111 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427545.1 98422 R 458234 CDS YP_001427546.1 156501481 5524413 complement(98853..99245) 1 NC_009749.1 lipoprotein 99245 5524413 FTA_0112 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001427546.1 98853 R 458234 CDS YP_001427548.2 169656484 5524415 join(100047..100376,100376..100927) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 100927 5524415 FTA_0114 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427548.2 100047 D 458234 CDS YP_001427550.1 156501485 5524417 complement(100928..101800) 1 NC_009749.1 major facilitator transporter 101800 5524417 FTA_0116 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001427550.1 100928 R 458234 CDS YP_001427553.1 156501488 5522819 102588..103142 1 NC_009749.1 Several genes in Francisella necessary for replication in macrophages and for virulence including iglA, iglC, and iglD and pathogenicity determinant protein genes pdpD and pdpA, are regulated by MglA. PMID:17000729; intracellular growth locus subunit A 103142 iglA1 5522819 iglA1 Francisella tularensis subsp. holarctica FTNF002-00 intracellular growth locus subunit A YP_001427553.1 102588 D 458234 CDS YP_001427554.1 156501489 5522820 103156..104676 1 NC_009749.1 intracellular growth locus subunit B 104676 iglB1 5522820 iglB1 Francisella tularensis subsp. holarctica FTNF002-00 intracellular growth locus subunit B YP_001427554.1 103156 D 458234 CDS YP_001427555.1 156501490 5522821 104687..105322 1 NC_009749.1 intracellular growth locus subunit C 105322 iglC1 5522821 iglC1 Francisella tularensis subsp. holarctica FTNF002-00 intracellular growth locus subunit C YP_001427555.1 104687 D 458234 CDS YP_001427556.1 156501491 5522822 105343..106539 1 NC_009749.1 intracellular growth locus subunit D 106539 iglD1 5522822 iglD1 Francisella tularensis subsp. holarctica FTNF002-00 intracellular growth locus subunit D YP_001427556.1 105343 D 458234 CDS YP_001427557.1 156501492 5522823 complement(106546..107121) 1 NC_009749.1 hypothetical protein 107121 5522823 FTA_0123 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427557.1 106546 R 458234 CDS YP_001427558.1 156501493 5522824 complement(107139..111125) 1 NC_009749.1 Several Francisella pathogenicity island (FPI) genes, including iglC, iglD, and pdpA to pdpD, regulated by MglA are necessary for replication in macrophages and for virulence. PMID:15375123, PMID:17000729; pathogenicity determinant protein PdpC 111125 pdpC1 5522824 pdpC1 Francisella tularensis subsp. holarctica FTNF002-00 pathogenicity determinant protein PdpC YP_001427558.1 107139 R 458234 CDS YP_001427559.1 156501494 5522825 complement(111165..111938) 1 NC_009749.1 conserved in Francisella spp.; hypothetical protein 111938 5522825 FTA_0125 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427559.1 111165 R 458234 CDS YP_001427560.1 156501495 5522826 complement(111904..113055) 1 NC_009749.1 hypothetical protein 113055 5522826 FTA_0126 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427560.1 111904 R 458234 CDS YP_001427561.1 156501496 5522827 complement(113077..113700) 1 NC_009749.1 hypothetical protein 113700 5522827 FTA_0127 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427561.1 113077 R 458234 CDS YP_001427562.1 156501497 5522828 complement(113713..115143) 1 NC_009749.1 hypothetical protein 115143 5522828 FTA_0128 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427562.1 113713 R 458234 CDS YP_001427563.2 169656485 5522829 complement(115156..115677) 1 NC_009749.1 hypothetical protein 115677 5522829 FTA_0129 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427563.2 115156 R 458234 CDS YP_001427565.1 156501500 5523817 complement(117414..117908) 1 NC_009749.1 hypothetical protein 117908 5523817 FTA_0131 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427565.1 117414 R 458234 CDS YP_001427566.1 156501501 5523818 complement(117921..118298) 1 NC_009749.1 lipoprotein 118298 5523818 FTA_0132 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001427566.1 117921 R 458234 CDS YP_001427567.1 156501502 5523819 complement(118288..121569) 1 NC_009749.1 Several Francisella pathogenicity island (FPI) genes, including iglC, iglD, and pdpA to pdpD, regulated by MglA are necessary for replication in macrophages and for virulence. PMID:15375123, PMID:17000729; pathogenicity deteminant protein PdpB 121569 pdpB1 5523819 pdpB1 Francisella tularensis subsp. holarctica FTNF002-00 pathogenicity deteminant protein PdpB YP_001427567.1 118288 R 458234 CDS YP_001427568.1 156501503 5523820 complement(121574..124036) 1 NC_009749.1 Several Francisella pathogenicity island (FPI) genes, including iglC, iglD, and pdpA to pdpD, regulated by MglA are necessary for replication in macrophages and for virulence. PMID:15375123, PMID:17000729; pathogenicity deteminant protein PdpA 124036 pdpA1 5523820 pdpA1 Francisella tularensis subsp. holarctica FTNF002-00 pathogenicity deteminant protein PdpA YP_001427568.1 121574 R 458234 CDS YP_001427571.2 169656486 5523823 join(130380..130709,130709..131260) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 131260 5523823 FTA_0138 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427571.2 130380 D 458234 CDS YP_001427575.1 156501510 5523827 complement(132640..133527) 1 NC_009749.1 branched-chain amino acid aminotransferase 133527 ilvE 5523827 ilvE Francisella tularensis subsp. holarctica FTNF002-00 branched-chain amino acid aminotransferase YP_001427575.1 132640 R 458234 CDS YP_001427576.1 156501511 5523828 complement(133928..136576) 1 NC_009749.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 136576 ppdK 5523828 ppdK Francisella tularensis subsp. holarctica FTNF002-00 pyruvate phosphate dikinase YP_001427576.1 133928 R 458234 CDS YP_001427577.1 156501512 5523829 complement(137388..139631) 1 NC_009749.1 ferrous iron transport protein B 139631 feoB 5523829 feoB Francisella tularensis subsp. holarctica FTNF002-00 ferrous iron transport protein B YP_001427577.1 137388 R 458234 CDS YP_001427578.2 169656487 5524593 complement(139700..140200) 1 NC_009749.1 hypothetical protein 140200 5524593 FTA_0145 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427578.2 139700 R 458234 CDS YP_001427579.2 169656488 5524594 complement(join(140160..140711,140711..141040)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 141040 5524594 FTA_0146 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427579.2 140160 R 458234 CDS YP_001427581.1 156501516 5524596 complement(141513..142145) 1 NC_009749.1 N-terminal truncation compared to Schu4 and FTW; hypothetical protein 142145 5524596 FTA_0148 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427581.1 141513 R 458234 CDS YP_001427582.1 156501517 5524597 complement(142796..143764) 1 NC_009749.1 hypothetical protein 143764 5524597 FTA_0149 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427582.1 142796 R 458234 CDS YP_001427583.1 156501518 5524598 143953..145803 1 NC_009749.1 ribonuclease II (RNB-like) family protein 145803 5524598 FTA_0150 Francisella tularensis subsp. holarctica FTNF002-00 ribonuclease II (RNB-like) family protein YP_001427583.1 143953 D 458234 CDS YP_001427584.2 169656489 5524599 146140..146808 1 NC_009749.1 carboxylesterase/phospholipase family protein 146808 5524599 FTA_0151 Francisella tularensis subsp. holarctica FTNF002-00 carboxylesterase/phospholipase family protein YP_001427584.2 146140 D 458234 CDS YP_001427585.1 156501520 5524600 146805..147707 1 NC_009749.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 147707 hemC 5524600 hemC Francisella tularensis subsp. holarctica FTNF002-00 porphobilinogen deaminase YP_001427585.1 146805 D 458234 CDS YP_001427586.1 156501521 5524601 147708..148043 1 NC_009749.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 148043 crcB 5524601 crcB Francisella tularensis subsp. holarctica FTNF002-00 camphor resistance protein CrcB YP_001427586.1 147708 D 458234 CDS YP_001427587.1 156501522 5524602 148096..148503 1 NC_009749.1 lipoprotein 148503 5524602 FTA_0154 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001427587.1 148096 D 458234 CDS YP_001427588.1 156501523 5524603 148643..148804 1 NC_009749.1 putative lipoprotein 148804 5524603 FTA_0155 Francisella tularensis subsp. holarctica FTNF002-00 putative lipoprotein YP_001427588.1 148643 D 458234 CDS YP_001427589.1 156501525 5524604 148856..149233 1 NC_009749.1 hypothetical protein 149233 5524604 FTA_0157 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427589.1 148856 D 458234 CDS YP_001427590.1 156501524 5524605 complement(149230..149403) 1 NC_009749.1 hypothetical protein 149403 5524605 FTA_0156 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427590.1 149230 R 458234 CDS YP_001427591.2 169656490 5523476 149532..151331 1 NC_009749.1 ABC transporter membrane protein 151331 5523476 FTA_0158 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter membrane protein YP_001427591.2 149532 D 458234 CDS YP_001427592.1 156501527 5523475 151350..152666 1 NC_009749.1 ABC transporter ATP-binding protein 152666 5523475 FTA_0159 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter ATP-binding protein YP_001427592.1 151350 D 458234 CDS YP_001427593.1 156501528 5523477 152753..154291 1 NC_009749.1 hypothetical protein 154291 5523477 FTA_0160 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427593.1 152753 D 458234 CDS YP_001427594.1 156501529 5523478 154397..156271 1 NC_009749.1 monovalent cation:proton antiporter-2 (CPA2) family protein 156271 5523478 FTA_0161 Francisella tularensis subsp. holarctica FTNF002-00 monovalent cation:proton antiporter-2 (CPA2) family protein YP_001427594.1 154397 D 458234 CDS YP_001427595.1 156501530 5523479 156256..156795 1 NC_009749.1 carbonic anhydrase/acyltransferase family protein 156795 5523479 FTA_0162 Francisella tularensis subsp. holarctica FTNF002-00 carbonic anhydrase/acyltransferase family protein YP_001427595.1 156256 D 458234 CDS YP_001427596.1 156501531 5523480 156758..157390 1 NC_009749.1 outer membrane lipoprotein LolB 157390 lolB 5523480 lolB Francisella tularensis subsp. holarctica FTNF002-00 outer membrane lipoprotein LolB YP_001427596.1 156758 D 458234 CDS YP_001427597.1 156501532 5523481 157378..158205 1 NC_009749.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 158205 ipk 5523481 ipk Francisella tularensis subsp. holarctica FTNF002-00 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_001427597.1 157378 D 458234 CDS YP_001427598.2 169656491 5523483 158394..158714 1 NC_009749.1 hypothetical protein 158714 5523483 FTA_0165 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427598.2 158394 D 458234 CDS YP_001427599.2 169656492 5524399 join(158738..159067,159067..159618) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 159618 5524399 FTA_0166 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427599.2 158738 D 458234 CDS YP_001427601.1 156501536 5523485 159674..159859 1 NC_009749.1 hypothetical protein 159859 5523485 FTA_0168 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427601.1 159674 D 458234 CDS YP_001427602.1 156501537 5523486 complement(159866..160213) 1 NC_009749.1 putative cytochrome b561 160213 5523486 FTA_0169 Francisella tularensis subsp. holarctica FTNF002-00 putative cytochrome b561 YP_001427602.1 159866 R 458234 CDS YP_001427603.1 156501538 5523487 complement(160460..161455) 1 NC_009749.1 phosphate transporter family protein 161455 5523487 FTA_0170 Francisella tularensis subsp. holarctica FTNF002-00 phosphate transporter family protein YP_001427603.1 160460 R 458234 CDS YP_001427604.1 156501539 5523101 complement(161473..162129) 1 NC_009749.1 hypothetical protein 162129 5523101 FTA_0171 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427604.1 161473 R 458234 CDS YP_001427605.1 156501540 5523102 162436..163911 1 NC_009749.1 N-terminal truncation compared to Schu4 and U112 proteins; phosphoesterase family protein 163911 5523102 FTA_0172 Francisella tularensis subsp. holarctica FTNF002-00 phosphoesterase family protein YP_001427605.1 162436 D 458234 CDS YP_001427606.1 156501541 5523103 complement(163918..164730) 1 NC_009749.1 biotin-dependent carboxylase 164730 5523103 FTA_0173 Francisella tularensis subsp. holarctica FTNF002-00 biotin-dependent carboxylase YP_001427606.1 163918 R 458234 CDS YP_001427608.2 169656493 5523105 complement(165431..166048) 1 NC_009749.1 putative allophanate hydrolase subunit 1 166048 5523105 FTA_0175 Francisella tularensis subsp. holarctica FTNF002-00 putative allophanate hydrolase subunit 1 YP_001427608.2 165431 R 458234 CDS YP_001427611.2 169656494 5523108 complement(join(167124..167675,167675..168004)) 1 NC_009749.1 programmed robisomal frameshift; transposase ISFTu1 168004 5523108 FTA_0178 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427611.2 167124 R 458234 CDS YP_001427614.1 156501549 5523111 complement(168364..169200) 1 NC_009749.1 universal stress protein 169200 uspA 5523111 uspA Francisella tularensis subsp. holarctica FTNF002-00 universal stress protein YP_001427614.1 168364 R 458234 CDS YP_001427615.1 156501550 5523112 complement(169276..172017) 1 NC_009749.1 DNA/RNA helicase 172017 5523112 FTA_0182 Francisella tularensis subsp. holarctica FTNF002-00 DNA/RNA helicase YP_001427615.1 169276 R 458234 CDS YP_001427616.1 156501551 5523113 complement(172001..172780) 1 NC_009749.1 hypothetical protein 172780 5523113 FTA_0183 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427616.1 172001 R 458234 CDS YP_001427617.2 169656495 5523919 complement(172852..173415) 1 NC_009749.1 HAD superfamily phosphatase 173415 5523919 FTA_0184 Francisella tularensis subsp. holarctica FTNF002-00 HAD superfamily phosphatase YP_001427617.2 172852 R 458234 CDS YP_001427618.1 156501553 5523920 173491..173667 1 NC_009749.1 hypothetical protein 173667 5523920 FTA_0185 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427618.1 173491 D 458234 CDS YP_001427619.2 169656496 5523921 173756..174226 1 NC_009749.1 hypothetical protein 174226 5523921 FTA_0186 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427619.2 173756 D 458234 CDS YP_001427620.1 156501555 5523922 complement(174237..175109) 1 NC_009749.1 tetrapyrrole (corrin/porphyrin) methylase family protein 175109 5523922 FTA_0187 Francisella tularensis subsp. holarctica FTNF002-00 tetrapyrrole (corrin/porphyrin) methylase family protein YP_001427620.1 174237 R 458234 CDS YP_001427621.1 156501556 5523923 complement(175102..176457) 1 NC_009749.1 UDP-N-acetylmuramate--L-alanine ligase 176457 murC 5523923 murC Francisella tularensis subsp. holarctica FTNF002-00 UDP-N-acetylmuramate--L-alanine ligase YP_001427621.1 175102 R 458234 CDS YP_001427622.1 156501557 5523924 complement(176524..177297) 1 NC_009749.1 shikimate 5-dehydrogenase 177297 aroE 5523924 aroE Francisella tularensis subsp. holarctica FTNF002-00 shikimate 5-dehydrogenase YP_001427622.1 176524 R 458234 CDS YP_001427623.1 156501558 5523925 177424..177882 1 NC_009749.1 hypothetical protein 177882 5523925 FTA_0190 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427623.1 177424 D 458234 CDS YP_001427624.1 156501559 5523926 177974..178108 1 NC_009749.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 178108 rpmH 5523926 rpmH Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L34 YP_001427624.1 177974 D 458234 CDS YP_001427625.1 156501560 5523927 178684..180339 1 NC_009749.1 inner-membrane protein 180339 5523927 FTA_0192 Francisella tularensis subsp. holarctica FTNF002-00 inner-membrane protein YP_001427625.1 178684 D 458234 CDS YP_001427626.1 156501561 5523928 180346..181245 1 NC_009749.1 lipid A biosynthesis acyltransferase 181245 5523928 FTA_0193 Francisella tularensis subsp. holarctica FTNF002-00 lipid A biosynthesis acyltransferase YP_001427626.1 180346 D 458234 CDS YP_001427627.1 156501562 5523929 181306..182229 1 NC_009749.1 lipid A biosysnthsis acyltransferase 182229 5523929 FTA_0194 Francisella tularensis subsp. holarctica FTNF002-00 lipid A biosysnthsis acyltransferase YP_001427627.1 181306 D 458234 CDS YP_001427628.1 156501563 5523930 182242..182649 1 NC_009749.1 prepilin-type N-terminal cleavage/methylation domain-containing protein 182649 5523930 FTA_0195 Francisella tularensis subsp. holarctica FTNF002-00 prepilin-type N-terminal cleavage/methylation domain-containing protein YP_001427628.1 182242 D 458234 CDS YP_001427629.1 156501564 5523931 182689..183258 1 NC_009749.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 183258 efp 5523931 efp Francisella tularensis subsp. holarctica FTNF002-00 elongation factor P YP_001427629.1 182689 D 458234 CDS YP_001427630.1 156501565 5524567 183261..183797 1 NC_009749.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 183797 5524567 FTA_0197 Francisella tularensis subsp. holarctica FTNF002-00 oligoribonuclease YP_001427630.1 183261 D 458234 CDS YP_001427631.1 156501566 5524568 183832..184026 1 NC_009749.1 hypothetical protein 184026 5524568 FTA_0198 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427631.1 183832 D 458234 CDS YP_001427632.2 169656497 5524569 join(184050..184379,184379..184930) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 184930 5524569 FTA_0199 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427632.2 184050 D 458234 CDS YP_001427634.1 156501568 5524571 complement(184908..186026) 1 NC_009749.1 major facilitator transporter 186026 5524571 FTA_0200 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001427634.1 184908 R 458234 CDS YP_001427635.1 156501570 5524573 complement(186094..186834) 1 NC_009749.1 prediction using TransportDB and PF00497; ABC transporter perplasmic protein 186834 5524573 FTA_0202 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter perplasmic protein YP_001427635.1 186094 R 458234 CDS YP_001427636.1 156501571 5524572 complement(187027..188208) 1 NC_009749.1 cytochrome D ubiquinol oxidase subunit II 188208 cydB 5524572 cydB Francisella tularensis subsp. holarctica FTNF002-00 cytochrome D ubiquinol oxidase subunit II YP_001427636.1 187027 R 458234 CDS YP_001427637.2 169656498 5524574 complement(188231..189985) 1 NC_009749.1 cytochrome D ubiquinol oxidase subunit 1 189985 5524574 FTA_0204 Francisella tularensis subsp. holarctica FTNF002-00 cytochrome D ubiquinol oxidase subunit 1 YP_001427637.2 188231 R 458234 CDS YP_001427638.1 156501573 5524575 complement(190438..191748) 1 NC_009749.1 major facilitator transporter 191748 5524575 FTA_0205 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001427638.1 190438 R 458234 CDS YP_001427639.1 156501574 5524576 192165..193067 1 NC_009749.1 cytochrome C oxidase /ubiquinol oxidase subunit II 193067 cyoA 5524576 cyoA Francisella tularensis subsp. holarctica FTNF002-00 cytochrome C oxidase /ubiquinol oxidase subunit II YP_001427639.1 192165 D 458234 CDS YP_001427640.1 156501575 5524577 193199..195136 1 NC_009749.1 cytochrome C oxidase/ubiquinol oxidase subunit I 195136 cyoB 5524577 cyoB Francisella tularensis subsp. holarctica FTNF002-00 cytochrome C oxidase/ubiquinol oxidase subunit I YP_001427640.1 193199 D 458234 CDS YP_001427641.1 156501576 5524578 195133..195735 1 NC_009749.1 cytochrome C oxidase/ubiquinol oxidase subunit III 195735 cyoC 5524578 cyoC Francisella tularensis subsp. holarctica FTNF002-00 cytochrome C oxidase/ubiquinol oxidase subunit III YP_001427641.1 195133 D 458234 CDS YP_001427642.1 156501577 5524579 195737..196069 1 NC_009749.1 cytochrome C oxidase/ubiquinol oxidase subunit IV 196069 cyoD 5524579 cyoD Francisella tularensis subsp. holarctica FTNF002-00 cytochrome C oxidase/ubiquinol oxidase subunit IV YP_001427642.1 195737 D 458234 CDS YP_001427643.1 156501578 5522742 196100..196948 1 NC_009749.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 196948 cyoE 5522742 cyoE Francisella tularensis subsp. holarctica FTNF002-00 protoheme IX farnesyltransferase YP_001427643.1 196100 D 458234 CDS YP_001427646.1 156501581 5522745 complement(198203..198898) 1 NC_009749.1 radical SAM domain-containing protein 198898 5522745 FTA_0213 Francisella tularensis subsp. holarctica FTNF002-00 radical SAM domain-containing protein YP_001427646.1 198203 R 458234 CDS YP_001427647.1 156501582 5522746 complement(198898..199749) 1 NC_009749.1 pyridoxal kinase 199749 pdxY 5522746 pdxY Francisella tularensis subsp. holarctica FTNF002-00 pyridoxal kinase YP_001427647.1 198898 R 458234 CDS YP_001427648.1 156501583 5522747 complement(199756..200190) 1 NC_009749.1 hypothetical protein 200190 5522747 FTA_0215 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427648.1 199756 R 458234 CDS YP_001427649.1 156501584 5522748 200336..201292 1 NC_009749.1 methanol dehydrogenase regulatory protein 201292 5522748 FTA_0216 Francisella tularensis subsp. holarctica FTNF002-00 methanol dehydrogenase regulatory protein YP_001427649.1 200336 D 458234 CDS YP_001427650.1 156501585 5522749 201305..202216 1 NC_009749.1 hypothetical protein 202216 5522749 FTA_0217 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427650.1 201305 D 458234 CDS YP_001427651.1 156501586 5522750 202206..202682 1 NC_009749.1 hypothetical protein 202682 5522750 FTA_0218 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427651.1 202206 D 458234 CDS YP_001427652.1 156501587 5522751 202679..203680 1 NC_009749.1 hypothetical protein 203680 5522751 FTA_0219 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427652.1 202679 D 458234 CDS YP_001427653.2 169656499 5522752 203682..204680 1 NC_009749.1 hypothetical protein 204680 5522752 FTA_0220 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427653.2 203682 D 458234 CDS YP_001427654.1 156501589 5522753 204671..205351 1 NC_009749.1 hypothetical protein 205351 5522753 FTA_0221 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427654.1 204671 D 458234 CDS YP_001427655.1 156501590 5522754 205341..206966 1 NC_009749.1 hypothetical protein 206966 5522754 FTA_0222 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427655.1 205341 D 458234 CDS YP_001427656.2 169656500 5524465 206973..207641 1 NC_009749.1 pyrrolidone-carboxylate peptidase 207641 pcp 5524465 pcp Francisella tularensis subsp. holarctica FTNF002-00 pyrrolidone-carboxylate peptidase YP_001427656.2 206973 D 458234 CDS YP_001427657.1 156501592 5524466 207649..208131 1 NC_009749.1 putative cytochrome c-type biogenesis protein 208131 5524466 FTA_0224 Francisella tularensis subsp. holarctica FTNF002-00 putative cytochrome c-type biogenesis protein YP_001427657.1 207649 D 458234 CDS YP_001427658.1 156501593 5524467 208165..208602 1 NC_009749.1 DNA polymerase III subunit chi 208602 5524467 FTA_0225 Francisella tularensis subsp. holarctica FTNF002-00 DNA polymerase III subunit chi YP_001427658.1 208165 D 458234 CDS YP_001427659.1 156501594 5524468 208734..211493 1 NC_009749.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 211493 valS 5524468 valS Francisella tularensis subsp. holarctica FTNF002-00 valyl-tRNA synthetase YP_001427659.1 208734 D 458234 CDS YP_001427660.1 156501595 5524469 211522..212409 1 NC_009749.1 hypothetical protein 212409 5524469 FTA_0227 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427660.1 211522 D 458234 CDS YP_001427661.1 156501596 5524470 212364..213350 1 NC_009749.1 hypothetical protein 213350 5524470 FTA_0228 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427661.1 212364 D 458234 CDS YP_001427662.1 156501598 5524471 213564..213845 1 NC_009749.1 hypothetical protein 213845 5524471 FTA_0230 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427662.1 213564 D 458234 CDS YP_001427663.1 156501597 5524472 complement(213842..214999) 1 NC_009749.1 L-lactate dehydrogenase 214999 5524472 FTA_0229 Francisella tularensis subsp. holarctica FTNF002-00 L-lactate dehydrogenase YP_001427663.1 213842 R 458234 CDS YP_001427664.1 156501599 5524474 complement(214989..215672) 1 NC_009749.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 215672 5524474 FTA_0231 Francisella tularensis subsp. holarctica FTNF002-00 dihydropteridine reductase YP_001427664.1 214989 R 458234 CDS YP_001427665.2 169656501 5524473 215812..216189 1 NC_009749.1 MutT/NUDIX family hydrolase 216189 5524473 FTA_0232 Francisella tularensis subsp. holarctica FTNF002-00 MutT/NUDIX family hydrolase YP_001427665.2 215812 D 458234 CDS YP_001427666.1 156501601 5524475 216362..217753 1 NC_009749.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 217753 fumC 5524475 fumC Francisella tularensis subsp. holarctica FTNF002-00 fumarate hydratase YP_001427666.1 216362 D 458234 CDS YP_001427667.1 156501602 5524476 217883..219289 1 NC_009749.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 219289 gltX 5524476 gltX Francisella tularensis subsp. holarctica FTNF002-00 glutamyl-tRNA synthetase YP_001427667.1 217883 D 458234 CDS YP_001715623.1 169656791 5983824 219438..220253 1 NC_009749.1 hypothetical protein 220253 5983824 FTA_2142 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001715623.1 219438 D 458234 CDS YP_001427671.1 156501606 5523147 complement(223097..224020) 1 NC_009749.1 hypothetical protein 224020 5523147 FTA_0238 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427671.1 223097 R 458234 CDS YP_001427672.1 156501607 5524402 complement(224102..224644) 1 NC_009749.1 dihydrofolate reductase type I 224644 folA 5524402 folA Francisella tularensis subsp. holarctica FTNF002-00 dihydrofolate reductase type I YP_001427672.1 224102 R 458234 CDS YP_001427673.2 394894374 5523148 224837..225556 1 NC_009749.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 225556 rpsB 5523148 rpsB Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S2 YP_001427673.2 224837 D 458234 CDS YP_001427674.1 156501609 5523149 225578..226447 1 NC_009749.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 226447 tsf 5523149 tsf Francisella tularensis subsp. holarctica FTNF002-00 elongation factor Ts YP_001427674.1 225578 D 458234 CDS YP_001427675.1 156501610 5523150 226451..227200 1 NC_009749.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 227200 pyrH 5523150 pyrH Francisella tularensis subsp. holarctica FTNF002-00 uridylate kinase YP_001427675.1 226451 D 458234 CDS YP_001427676.1 156501611 5523151 227230..227787 1 NC_009749.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 227787 frr 5523151 frr Francisella tularensis subsp. holarctica FTNF002-00 ribosome recycling factor YP_001427676.1 227230 D 458234 CDS YP_001427677.1 156501612 5523152 227871..228593 1 NC_009749.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 228593 uppS 5523152 uppS Francisella tularensis subsp. holarctica FTNF002-00 undecaprenyl pyrophosphate synthase YP_001427677.1 227871 D 458234 CDS YP_001427678.1 156501613 5523153 228607..229401 1 NC_009749.1 phosphatidate cytidylyltransferase 229401 cdsA 5523153 cdsA Francisella tularensis subsp. holarctica FTNF002-00 phosphatidate cytidylyltransferase YP_001427678.1 228607 D 458234 CDS YP_001427679.1 156501614 5523154 229411..229857 1 NC_009749.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 229857 dut 5523154 dut Francisella tularensis subsp. holarctica FTNF002-00 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_001427679.1 229411 D 458234 CDS YP_001427680.1 156501615 5523155 229861..230457 1 NC_009749.1 phosphatidylglycerophosphate synthetase 230457 pgsA 5523155 pgsA Francisella tularensis subsp. holarctica FTNF002-00 phosphatidylglycerophosphate synthetase YP_001427680.1 229861 D 458234 CDS YP_001427681.1 156501616 5523156 230592..230966 1 NC_009749.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 230966 rpsL 5523156 rpsL Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S12 YP_001427681.1 230592 D 458234 CDS YP_001427682.1 156501617 5523517 231005..231478 1 NC_009749.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 231478 rpsG 5523517 rpsG Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S7 YP_001427682.1 231005 D 458234 CDS YP_001427683.1 156501618 5523518 231493..233607 1 NC_009749.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 233607 fusA 5523518 fusA Francisella tularensis subsp. holarctica FTNF002-00 elongation factor G YP_001427683.1 231493 D 458234 CDS YP_001427684.1 156501619 5523519 233628..233945 1 NC_009749.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 233945 rpsJ 5523519 rpsJ Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S10 YP_001427684.1 233628 D 458234 CDS YP_001427685.1 156501620 5523520 234049..234681 1 NC_009749.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 234681 rplC 5523520 rplC Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L3 YP_001427685.1 234049 D 458234 CDS YP_001427686.1 156501621 5523521 234714..235337 1 NC_009749.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 235337 rplD 5523521 rplD Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L4 YP_001427686.1 234714 D 458234 CDS YP_001427687.1 156501622 5523522 235334..235633 1 NC_009749.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 235633 rplW 5523522 rplW Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L23 YP_001427687.1 235334 D 458234 CDS YP_001427688.1 156501623 5523523 235655..236479 1 NC_009749.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 236479 rplB 5523523 rplB Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L2 YP_001427688.1 235655 D 458234 CDS YP_001427689.1 156501624 5523524 236494..236772 1 NC_009749.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 236772 rpsS 5523524 rpsS Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S19 YP_001427689.1 236494 D 458234 CDS YP_001427690.1 156501625 5523525 236788..237123 1 NC_009749.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 237123 rplV 5523525 rplV Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L22 YP_001427690.1 236788 D 458234 CDS YP_001427691.1 156501626 5523526 237138..237809 1 NC_009749.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 237809 rpsC 5523526 rpsC Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S3 YP_001427691.1 237138 D 458234 CDS YP_001427692.1 156501627 5523527 237809..238222 1 NC_009749.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 238222 rplP 5523527 rplP Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L16 YP_001427692.1 237809 D 458234 CDS YP_003856785.1 304360650 9711849 238222..238422 1 NC_009749.1 50S ribosomal protein L29 238422 9711849 FTA_2200 Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L29 YP_003856785.1 238222 D 458234 CDS YP_001427693.1 156501628 5523528 238435..238686 1 NC_009749.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 238686 rpsQ 5523528 rpsQ Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S17 YP_001427693.1 238435 D 458234 CDS YP_001427694.1 156501629 5523529 238778..239146 1 NC_009749.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 239146 rplN 5523529 rplN Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L14 YP_001427694.1 238778 D 458234 CDS YP_001427695.1 156501630 5522600 239168..239485 1 NC_009749.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 239485 rplX 5522600 rplX Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L24 YP_001427695.1 239168 D 458234 CDS YP_001427696.1 156501631 5522601 239497..240036 1 NC_009749.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 240036 rplE 5522601 rplE Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L5 YP_001427696.1 239497 D 458234 CDS YP_001427697.1 156501632 5522602 240055..240360 1 NC_009749.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 240360 rpsN 5522602 rpsN Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S14 YP_001427697.1 240055 D 458234 CDS YP_001427698.2 169656502 5522603 240377..240775 1 NC_009749.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 240775 rpsH 5522603 rpsH Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S8 YP_001427698.2 240377 D 458234 CDS YP_001427699.1 156501634 5522604 240794..241330 1 NC_009749.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 241330 rplF 5522604 rplF Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L6 YP_001427699.1 240794 D 458234 CDS YP_001427700.1 156501635 5522605 241353..241706 1 NC_009749.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 241706 rplR 5522605 rplR Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L18 YP_001427700.1 241353 D 458234 CDS YP_001427701.1 156501636 5522606 241734..242234 1 NC_009749.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 242234 rpsE 5522606 rpsE Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S5 YP_001427701.1 241734 D 458234 CDS YP_001427702.1 156501637 5522607 242241..242426 1 NC_009749.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 242426 rpmD 5522607 rpmD Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L30 YP_001427702.1 242241 D 458234 CDS YP_001427703.1 156501638 5522608 242433..242864 1 NC_009749.1 late assembly protein; 50S ribosomal protein L15 242864 rplO 5522608 rplO Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L15 YP_001427703.1 242433 D 458234 CDS YP_001427704.1 156501639 5522609 242875..244200 1 NC_009749.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 244200 secY 5522609 secY Francisella tularensis subsp. holarctica FTNF002-00 preprotein translocase subunit SecY YP_001427704.1 242875 D 458234 CDS YP_001427705.1 156501640 5522610 244454..244810 1 NC_009749.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 244810 rpsM 5522610 rpsM Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S13 YP_001427705.1 244454 D 458234 CDS YP_001427706.1 156501641 5522611 244849..245238 1 NC_009749.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 245238 rpsK 5522611 rpsK Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S11 YP_001427706.1 244849 D 458234 CDS YP_001427707.1 156501642 5522612 245260..245880 1 NC_009749.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 245880 rpsD 5522612 rpsD Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S4 YP_001427707.1 245260 D 458234 CDS YP_001427708.1 156501643 5522700 245938..246909 1 NC_009749.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 246909 rpoA1 5522700 rpoA1 Francisella tularensis subsp. holarctica FTNF002-00 DNA-directed RNA polymerase subunit alpha YP_001427708.1 245938 D 458234 CDS YP_001427709.1 156501644 5522701 246954..247391 1 NC_009749.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 247391 rplQ 5522701 rplQ Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L17 YP_001427709.1 246954 D 458234 CDS YP_001427710.2 169656503 5522702 join(247545..247874,247874..248425) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 248425 5522702 FTA_0277 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427710.2 247545 D 458234 CDS YP_001427712.2 169656504 5522704 complement(248621..249616) 1 NC_009749.1 hypothetical protein 249616 5522704 FTA_0279 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427712.2 248621 R 458234 CDS YP_001427714.2 169656505 5522706 complement(join(250452..250949,250949..251278)) 1 NC_009749.1 shorter ORF, programmed ribosomal frameshift; transposase ISFtu1 251278 5522706 FTA_0281 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001427714.2 250452 R 458234 CDS YP_001427716.1 156501651 5522708 251440..253326 1 NC_009749.1 molecular chaperone; heat shock protein 90 253326 htpG 5522708 htpG Francisella tularensis subsp. holarctica FTNF002-00 heat shock protein 90 YP_001427716.1 251440 D 458234 CDS YP_001427718.2 169656506 5522710 complement(join(253556..254107,254107..254436)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 254436 5522710 FTA_0285 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427718.2 253556 R 458234 CDS YP_001427719.1 156501654 5522711 complement(254628..255977) 1 NC_009749.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 255977 5522711 FTA_0286 Francisella tularensis subsp. holarctica FTNF002-00 glutamate dehydrogenase YP_001427719.1 254628 R 458234 CDS YP_001427720.1 156501655 5522712 256436..257125 1 NC_009749.1 transposase ISFTu2 257125 5522712 FTA_0287 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001427720.1 256436 D 458234 CDS YP_001427721.1 156501656 5523946 257423..258013 1 NC_009749.1 hypothetical protein 258013 5523946 FTA_0288 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427721.1 257423 D 458234 CDS YP_001427722.1 156501657 5523947 258026..259195 1 NC_009749.1 diaminopimelate decarboxylase 259195 lysA 5523947 lysA Francisella tularensis subsp. holarctica FTNF002-00 diaminopimelate decarboxylase YP_001427722.1 258026 D 458234 CDS YP_001427723.1 156501658 5523948 259207..260586 1 NC_009749.1 amino acid permease 260586 5523948 FTA_0290 Francisella tularensis subsp. holarctica FTNF002-00 amino acid permease YP_001427723.1 259207 D 458234 CDS YP_001427724.1 156501659 5523949 complement(260628..260867) 1 NC_009749.1 hypothetical protein 260867 5523949 FTA_0291 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427724.1 260628 R 458234 CDS YP_001427725.1 156501660 5523950 complement(261063..261635) 1 NC_009749.1 methylated-DNA--protein-cysteine methyltransferase 261635 5523950 FTA_0292 Francisella tularensis subsp. holarctica FTNF002-00 methylated-DNA--protein-cysteine methyltransferase YP_001427725.1 261063 R 458234 CDS YP_001427726.1 156501661 5523951 261665..262384 1 NC_009749.1 hypothetical protein 262384 5523951 FTA_0293 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427726.1 261665 D 458234 CDS YP_001427727.1 156501662 5523952 262387..263805 1 NC_009749.1 pyridine nucleotide-disulfide oxidoreductase 263805 5523952 FTA_0294 Francisella tularensis subsp. holarctica FTNF002-00 pyridine nucleotide-disulfide oxidoreductase YP_001427727.1 262387 D 458234 CDS YP_001427728.1 156501663 5523953 263802..264401 1 NC_009749.1 CDP-alcohol phosphatidyltransferase 264401 5523953 FTA_0295 Francisella tularensis subsp. holarctica FTNF002-00 CDP-alcohol phosphatidyltransferase YP_001427728.1 263802 D 458234 CDS YP_001427729.1 156501664 5523954 264398..264727 1 NC_009749.1 hypothetical protein 264727 5523954 FTA_0296 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427729.1 264398 D 458234 CDS YP_001427730.1 156501665 5523955 complement(264797..265513) 1 NC_009749.1 hypothetical protein 265513 5523955 FTA_0297 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427730.1 264797 R 458234 CDS YP_001427731.1 156501667 5523956 265712..266638 1 NC_009749.1 chaperone DnaJ domain-containing protein 266638 5523956 FTA_0299 Francisella tularensis subsp. holarctica FTNF002-00 chaperone DnaJ domain-containing protein YP_001427731.1 265712 D 458234 CDS YP_001427732.1 156501666 5523957 complement(266628..267512) 1 NC_009749.1 drug/metabolite exporter family integral membrane protein 267512 5523957 FTA_0298 Francisella tularensis subsp. holarctica FTNF002-00 drug/metabolite exporter family integral membrane protein YP_001427732.1 266628 R 458234 CDS YP_001427733.1 156501668 5522558 267703..268899 1 NC_009749.1 tryptophan/tyrosine permease family protein 268899 5522558 FTA_0300 Francisella tularensis subsp. holarctica FTNF002-00 tryptophan/tyrosine permease family protein YP_001427733.1 267703 D 458234 CDS YP_001427736.1 156501671 5522561 269659..271602 1 NC_009749.1 putative GTP pyrophosphokinase 271602 5522561 FTA_0303 Francisella tularensis subsp. holarctica FTNF002-00 putative GTP pyrophosphokinase YP_001427736.1 269659 D 458234 CDS YP_001427737.1 156501672 5524331 complement(271718..272350) 1 NC_009749.1 hypothetical protein 272350 5524331 FTA_0304 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427737.1 271718 R 458234 CDS YP_001427738.1 156501673 5522562 complement(272427..273005) 1 NC_009749.1 hypothetical protein 273005 5522562 FTA_0305 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427738.1 272427 R 458234 CDS YP_001427739.1 156501674 5522563 273093..273707 1 NC_009749.1 hypothetical protein 273707 5522563 FTA_0306 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427739.1 273093 D 458234 CDS YP_001427740.1 156501675 5522564 complement(273714..274439) 1 NC_009749.1 hypothetical protein 274439 5522564 FTA_0307 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427740.1 273714 R 458234 CDS YP_001427741.1 156501676 5522565 complement(274439..275317) 1 NC_009749.1 phage integrase family protein 275317 5522565 FTA_0308 Francisella tularensis subsp. holarctica FTNF002-00 phage integrase family protein YP_001427741.1 274439 R 458234 CDS YP_001427742.2 169656507 5522566 complement(275327..276538) 1 NC_009749.1 aromatic amino acid transporter 276538 5522566 FTA_0309 Francisella tularensis subsp. holarctica FTNF002-00 aromatic amino acid transporter YP_001427742.2 275327 R 458234 CDS YP_001427744.1 156501679 5522568 complement(277978..278421) 1 NC_009749.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 278421 secB2 5522568 secB2 Francisella tularensis subsp. holarctica FTNF002-00 preprotein translocase subunit SecB YP_001427744.1 277978 R 458234 CDS YP_001427745.1 156501680 5522569 complement(278498..281032) 1 NC_009749.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 281032 mutS 5522569 mutS Francisella tularensis subsp. holarctica FTNF002-00 DNA mismatch repair protein MutS YP_001427745.1 278498 R 458234 CDS YP_001427746.1 156501681 5522570 281199..282146 1 NC_009749.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 282146 accA 5522570 accA Francisella tularensis subsp. holarctica FTNF002-00 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_001427746.1 281199 D 458234 CDS YP_001427747.1 156501682 5523775 282166..282669 1 NC_009749.1 hypothetical protein 282669 5523775 FTA_0314 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427747.1 282166 D 458234 CDS YP_001427748.1 156501683 5523776 282650..283663 1 NC_009749.1 hypothetical protein 283663 5523776 FTA_0315 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427748.1 282650 D 458234 CDS YP_001427749.1 156501684 5523777 283672..285633 1 NC_009749.1 hypothetical protein 285633 5523777 FTA_0316 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427749.1 283672 D 458234 CDS YP_001427750.1 156501685 5523778 285630..286514 1 NC_009749.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 286514 murQ 5523778 murQ Francisella tularensis subsp. holarctica FTNF002-00 N-acetylmuramic acid 6-phosphate etherase YP_001427750.1 285630 D 458234 CDS YP_001427751.1 156501686 5523779 286516..286911 1 NC_009749.1 hypothetical protein 286911 5523779 FTA_0318 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427751.1 286516 D 458234 CDS YP_001427752.1 156501687 5523780 complement(287206..287334) 1 NC_009749.1 hypothetical protein 287334 5523780 FTA_0319 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427752.1 287206 R 458234 CDS YP_001427753.1 156501688 5523781 287496..287948 1 NC_009749.1 hypothetical protein 287948 5523781 FTA_0320 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427753.1 287496 D 458234 CDS YP_001427754.1 156501689 5523782 288129..289298 1 NC_009749.1 transposase ISFtu2 289298 5523782 FTA_0321 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu2 YP_001427754.1 288129 D 458234 CDS YP_001427755.2 169656508 5523783 complement(289695..290993) 1 NC_009749.1 monovalent cation:proton antiporter family protein 290993 5523783 FTA_0322 Francisella tularensis subsp. holarctica FTNF002-00 monovalent cation:proton antiporter family protein YP_001427755.2 289695 R 458234 CDS YP_001427756.1 156501691 5523784 290803..290940 1 NC_009749.1 hypothetical protein 290940 5523784 FTA_0323 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427756.1 290803 D 458234 CDS YP_001427757.1 156501692 5523785 complement(291003..291728) 1 NC_009749.1 hypothetical protein 291728 5523785 FTA_0324 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427757.1 291003 R 458234 CDS YP_001427758.1 156501693 5523786 complement(291730..292734) 1 NC_009749.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 292734 trpS 5523786 trpS Francisella tularensis subsp. holarctica FTNF002-00 tryptophanyl-tRNA synthetase YP_001427758.1 291730 R 458234 CDS YP_001427759.1 156501694 5522977 complement(293031..293645) 1 NC_009749.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 293645 coaE 5522977 coaE Francisella tularensis subsp. holarctica FTNF002-00 dephospho-CoA kinase YP_001427759.1 293031 R 458234 CDS YP_001427760.1 156501695 5522982 293774..294910 1 NC_009749.1 hypothetical protein 294910 5522982 FTA_0327 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427760.1 293774 D 458234 CDS YP_001427761.1 156501696 5524336 295194..297875 1 NC_009749.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 297875 aceE 5524336 aceE Francisella tularensis subsp. holarctica FTNF002-00 pyruvate dehydrogenase subunit E1 YP_001427761.1 295194 D 458234 CDS YP_001427762.1 156501697 5524337 297893..299488 1 NC_009749.1 dihydrolipoamide acetyltransferase 299488 aceF 5524337 aceF Francisella tularensis subsp. holarctica FTNF002-00 dihydrolipoamide acetyltransferase YP_001427762.1 297893 D 458234 CDS YP_001427763.1 156501698 5524338 299502..300914 1 NC_009749.1 dihydrolipoamide dehydrogenase 300914 lpdA 5524338 lpdA Francisella tularensis subsp. holarctica FTNF002-00 dihydrolipoamide dehydrogenase YP_001427763.1 299502 D 458234 CDS YP_001427764.1 156501699 5524339 complement(301153..301290) 1 NC_009749.1 putative transposase 301290 5524339 FTA_0331 Francisella tularensis subsp. holarctica FTNF002-00 putative transposase YP_001427764.1 301153 R 458234 CDS YP_001427765.2 169656509 5524340 join(301284..301613,301613..302164) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 302164 5524340 FTA_0332 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427765.2 301284 D 458234 CDS YP_001427767.2 169656510 5524342 302292..302939 1 NC_009749.1 NUDIX family hydrolase 302939 5524342 FTA_0334 Francisella tularensis subsp. holarctica FTNF002-00 NUDIX family hydrolase YP_001427767.2 302292 D 458234 CDS YP_001427768.1 156501703 5524343 302957..303310 1 NC_009749.1 arsenate reductase 303310 5524343 FTA_0335 Francisella tularensis subsp. holarctica FTNF002-00 arsenate reductase YP_001427768.1 302957 D 458234 CDS YP_001427769.1 156501704 5524344 complement(303334..303669) 1 NC_009749.1 hypothetical protein 303669 5524344 FTA_0336 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427769.1 303334 R 458234 CDS YP_001427770.1 156501705 5524345 303997..304146 1 NC_009749.1 hypothetical protein 304146 5524345 FTA_0337 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427770.1 303997 D 458234 CDS YP_001427771.1 156501706 5524346 complement(304169..305482) 1 NC_009749.1 xanthine/uracil permease family protein 305482 5524346 FTA_0338 Francisella tularensis subsp. holarctica FTNF002-00 xanthine/uracil permease family protein YP_001427771.1 304169 R 458234 CDS YP_001427772.1 156501707 5524347 complement(305549..307135) 1 NC_009749.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 307135 5524347 FTA_0339 Francisella tularensis subsp. holarctica FTNF002-00 aspartate aminotransferase YP_001427772.1 305549 R 458234 CDS YP_001427773.1 156501708 5523987 307291..307428 1 NC_009749.1 hypothetical protein 307428 5523987 FTA_0340 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427773.1 307291 D 458234 CDS YP_001427775.1 156501710 5523989 308478..308699 1 NC_009749.1 hypothetical protein 308699 5523989 FTA_0342 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427775.1 308478 D 458234 CDS YP_001427776.1 156501711 5523990 308734..308865 1 NC_009749.1 hypothetical protein 308865 5523990 FTA_0343 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427776.1 308734 D 458234 CDS YP_001427779.2 169656511 5523993 complement(310117..311370) 1 NC_009749.1 OmpA family protein 311370 5523993 FTA_0346 Francisella tularensis subsp. holarctica FTNF002-00 OmpA family protein YP_001427779.2 310117 R 458234 CDS YP_001427780.1 156501715 5523994 311562..312026 1 NC_009749.1 FKBP-type peptidyl-prolyl cis-trans isomerase 312026 5523994 FTA_0347 Francisella tularensis subsp. holarctica FTNF002-00 FKBP-type peptidyl-prolyl cis-trans isomerase YP_001427780.1 311562 D 458234 CDS YP_001427781.1 156501716 5523995 312007..312963 1 NC_009749.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 312963 ispH 5523995 ispH Francisella tularensis subsp. holarctica FTNF002-00 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_001427781.1 312007 D 458234 CDS YP_001427782.1 156501717 5523996 312965..313327 1 NC_009749.1 chorismate mutase 313327 aroH 5523996 aroH Francisella tularensis subsp. holarctica FTNF002-00 chorismate mutase YP_001427782.1 312965 D 458234 CDS YP_001427783.1 156501718 5523997 313336..314157 1 NC_009749.1 CDP-alcohol phosphatidyltransferase 314157 pssA 5523997 pssA Francisella tularensis subsp. holarctica FTNF002-00 CDP-alcohol phosphatidyltransferase YP_001427783.1 313336 D 458234 CDS YP_001427784.1 156501719 5523998 complement(314162..314368) 1 NC_009749.1 hypothetical protein 314368 5523998 FTA_0351 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427784.1 314162 R 458234 CDS YP_001427785.1 156501720 5523999 314538..315245 1 NC_009749.1 TolQ protein 315245 tolQ 5523999 tolQ Francisella tularensis subsp. holarctica FTNF002-00 TolQ protein YP_001427785.1 314538 D 458234 CDS YP_001427786.1 156501721 5523073 315363..315701 1 NC_009749.1 TolR protein 315701 tolR 5523073 tolR Francisella tularensis subsp. holarctica FTNF002-00 TolR protein YP_001427786.1 315363 D 458234 CDS YP_001427787.1 156501722 5523074 315688..316599 1 NC_009749.1 tol-pal system component, TolA 316599 tolA 5523074 tolA Francisella tularensis subsp. holarctica FTNF002-00 tol-pal system component, TolA YP_001427787.1 315688 D 458234 CDS YP_001427788.2 169656512 5523075 316599..317918 1 NC_009749.1 tol-pal system component, TolB protein 317918 tolB 5523075 tolB Francisella tularensis subsp. holarctica FTNF002-00 tol-pal system component, TolB protein YP_001427788.2 316599 D 458234 CDS YP_001427789.2 169656513 5523076 317922..318173 1 NC_009749.1 lipoprotein 318173 5523076 FTA_0356 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001427789.2 317922 D 458234 CDS YP_001427790.2 169656514 5523077 318192..318815 1 NC_009749.1 OmpA family peptidoglycan-associated lipoprotein 318815 pal 5523077 pal Francisella tularensis subsp. holarctica FTNF002-00 OmpA family peptidoglycan-associated lipoprotein YP_001427790.2 318192 D 458234 CDS YP_001427791.1 156501726 5523078 318922..320217 1 NC_009749.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 320217 rimO 5523078 rimO Francisella tularensis subsp. holarctica FTNF002-00 ribosomal protein S12 methylthiotransferase YP_001427791.1 318922 D 458234 CDS YP_001427792.1 156501727 5523079 320226..320576 1 NC_009749.1 acetyltransferase 320576 5523079 FTA_0359 Francisella tularensis subsp. holarctica FTNF002-00 acetyltransferase YP_001427792.1 320226 D 458234 CDS YP_001427793.2 169656515 5523080 join(320722..321051,321051..321602) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 321602 5523080 FTA_0360 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427793.2 320722 D 458234 CDS YP_001427797.1 156501732 5523084 323263..324792 1 NC_009749.1 deoxyribodipyrimidine photolyase-like protein 324792 5523084 FTA_0364 Francisella tularensis subsp. holarctica FTNF002-00 deoxyribodipyrimidine photolyase-like protein YP_001427797.1 323263 D 458234 CDS YP_001427798.2 169656516 5523086 325052..325984 1 NC_009749.1 sodium dependent symporter family protein 325984 5523086 FTA_0365 Francisella tularensis subsp. holarctica FTNF002-00 sodium dependent symporter family protein YP_001427798.2 325052 D 458234 CDS YP_001427802.1 156501737 5524526 327972..328958 1 NC_009749.1 hypothetical protein 328958 5524526 FTA_0369 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427802.1 327972 D 458234 CDS YP_001427805.2 169656517 5524528 complement(330346..330771) 1 NC_009749.1 hypothetical protein 330771 5524528 FTA_0372 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427805.2 330346 R 458234 CDS YP_001427806.2 169656518 5524529 complement(join(330743..331294,331294..331623)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 331623 5524529 FTA_0373 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427806.2 330743 R 458234 CDS YP_001427808.1 156501743 5524531 complement(331741..332100) 1 NC_009749.1 hypothetical protein 332100 5524531 FTA_0375 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427808.1 331741 R 458234 CDS YP_001427809.1 156501744 5524532 complement(332097..332966) 1 NC_009749.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; 4-hydroxybenzoate polyprenyltransferase 332966 ubiA 5524532 ubiA Francisella tularensis subsp. holarctica FTNF002-00 4-hydroxybenzoate polyprenyltransferase YP_001427809.1 332097 R 458234 CDS YP_001427810.1 156501745 5524533 complement(332969..333475) 1 NC_009749.1 chorismate pyruvate lyase 333475 ubiC 5524533 ubiC Francisella tularensis subsp. holarctica FTNF002-00 chorismate pyruvate lyase YP_001427810.1 332969 R 458234 CDS YP_001427811.1 156501746 5524534 333574..334281 1 NC_009749.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 334281 rph 5524534 rph Francisella tularensis subsp. holarctica FTNF002-00 ribonuclease PH YP_001427811.1 333574 D 458234 CDS YP_001427812.1 156501747 5524536 complement(334335..334658) 1 NC_009749.1 hypothetical protein 334658 5524536 FTA_0379 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427812.1 334335 R 458234 CDS YP_001427814.1 156501749 5523973 complement(335035..335670) 1 NC_009749.1 prepilin-type N-terminal cleavage/methylation domain-containing protein 335670 5523973 FTA_0381 Francisella tularensis subsp. holarctica FTNF002-00 prepilin-type N-terminal cleavage/methylation domain-containing protein YP_001427814.1 335035 R 458234 CDS YP_001427815.1 156501750 5523974 complement(335775..336848) 1 NC_009749.1 putative metalloprotease; heat shock protein HtpX 336848 5523974 FTA_0382 Francisella tularensis subsp. holarctica FTNF002-00 heat shock protein HtpX YP_001427815.1 335775 R 458234 CDS YP_001427816.1 156501751 5523975 complement(336852..337427) 1 NC_009749.1 LemA-like protein 337427 5523975 FTA_0383 Francisella tularensis subsp. holarctica FTNF002-00 LemA-like protein YP_001427816.1 336852 R 458234 CDS YP_001427824.1 156501759 5523983 complement(342583..342948) 1 NC_009749.1 ArsR family transcriptional regulator 342948 5523983 FTA_0391 Francisella tularensis subsp. holarctica FTNF002-00 ArsR family transcriptional regulator YP_001427824.1 342583 R 458234 CDS YP_001427825.1 156501760 5523984 343091..343744 1 NC_009749.1 hypothetical protein 343744 5523984 FTA_0392 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427825.1 343091 D 458234 CDS YP_001427826.1 156501761 5523986 complement(343756..343887) 1 NC_009749.1 hypothetical protein 343887 5523986 FTA_0393 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427826.1 343756 R 458234 CDS YP_001427827.1 156501762 5523985 343889..344026 1 NC_009749.1 hypothetical protein 344026 5523985 FTA_0394 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427827.1 343889 D 458234 CDS YP_001427828.1 156501763 5522859 344064..345062 1 NC_009749.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 345062 gpsA 5522859 gpsA Francisella tularensis subsp. holarctica FTNF002-00 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_001427828.1 344064 D 458234 CDS YP_001427829.2 169656519 5522860 complement(345063..345599) 1 NC_009749.1 colicin V production (CvpA) family protein 345599 5522860 FTA_0396 Francisella tularensis subsp. holarctica FTNF002-00 colicin V production (CvpA) family protein YP_001427829.2 345063 R 458234 CDS YP_001427830.1 156501765 5522861 complement(345604..346974) 1 NC_009749.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 346974 radA 5522861 radA Francisella tularensis subsp. holarctica FTNF002-00 DNA repair protein RadA YP_001427830.1 345604 R 458234 CDS YP_001427831.1 156501766 5522862 complement(346982..347752) 1 NC_009749.1 hypothetical protein 347752 5522862 FTA_0398 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427831.1 346982 R 458234 CDS YP_001427832.1 156501767 5522863 complement(347749..348348) 1 NC_009749.1 hypothetical protein 348348 5522863 FTA_0399 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427832.1 347749 R 458234 CDS YP_001427833.1 156501768 5522864 complement(348351..349409) 1 NC_009749.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 349409 aroC 5522864 aroC Francisella tularensis subsp. holarctica FTNF002-00 chorismate synthase YP_001427833.1 348351 R 458234 CDS YP_001427834.1 156501769 5522865 complement(349550..350203) 1 NC_009749.1 PQ loop repeat-containing membrane protein 350203 5522865 FTA_0401 Francisella tularensis subsp. holarctica FTNF002-00 PQ loop repeat-containing membrane protein YP_001427834.1 349550 R 458234 CDS YP_001427835.1 156501770 5522866 complement(350222..350734) 1 NC_009749.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 350734 msrB 5522866 msrB Francisella tularensis subsp. holarctica FTNF002-00 methionine sulfoxide reductase B YP_001427835.1 350222 R 458234 CDS YP_001427836.1 156501771 5522867 350895..351452 1 NC_009749.1 copper/zinc superoxide dismutase 351452 sodC 5522867 sodC Francisella tularensis subsp. holarctica FTNF002-00 copper/zinc superoxide dismutase YP_001427836.1 350895 D 458234 CDS YP_001427837.1 156501773 5522868 351456..352247 1 NC_009749.1 hypothetical protein 352247 5522868 FTA_0405 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427837.1 351456 D 458234 CDS YP_001427838.1 156501772 5522869 complement(352222..353616) 1 NC_009749.1 amino acid permease 353616 5522869 FTA_0404 Francisella tularensis subsp. holarctica FTNF002-00 amino acid permease YP_001427838.1 352222 R 458234 CDS YP_001427839.1 156501774 5522871 353766..354128 1 NC_009749.1 mannose-6-phosphate isomerase 354128 5522871 FTA_0406 Francisella tularensis subsp. holarctica FTNF002-00 mannose-6-phosphate isomerase YP_001427839.1 353766 D 458234 CDS YP_001427843.1 156501778 5524190 complement(355367..356557) 1 NC_009749.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 356557 5524190 FTA_0410 Francisella tularensis subsp. holarctica FTNF002-00 aspartate aminotransferase YP_001427843.1 355367 R 458234 CDS YP_001427844.1 156501779 5524191 356760..357647 1 NC_009749.1 cation transporter 357647 5524191 FTA_0411 Francisella tularensis subsp. holarctica FTNF002-00 cation transporter YP_001427844.1 356760 D 458234 CDS YP_001427845.1 156501780 5524192 357733..359382 1 NC_009749.1 DNA repair protein RecN 359382 recN 5524192 recN Francisella tularensis subsp. holarctica FTNF002-00 DNA repair protein RecN YP_001427845.1 357733 D 458234 CDS YP_001427848.1 156501783 5524195 complement(362144..362551) 1 NC_009749.1 type IV pilus assembly protein 362551 5524195 FTA_0415 Francisella tularensis subsp. holarctica FTNF002-00 type IV pilus assembly protein YP_001427848.1 362144 R 458234 CDS YP_001427849.1 156501784 5524196 362935..363654 1 NC_009749.1 PAP2 (2 phosphatidic acid phosphatase) family protein 363654 5524196 FTA_0416 Francisella tularensis subsp. holarctica FTNF002-00 PAP2 (2 phosphatidic acid phosphatase) family protein YP_001427849.1 362935 D 458234 CDS YP_001427850.1 156501785 5524197 363794..364642 1 NC_009749.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 364642 5524197 FTA_0417 Francisella tularensis subsp. holarctica FTNF002-00 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_001427850.1 363794 D 458234 CDS YP_001427851.1 156501786 5524198 364862..365905 1 NC_009749.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 365905 purM 5524198 purM Francisella tularensis subsp. holarctica FTNF002-00 phosphoribosylaminoimidazole synthetase YP_001427851.1 364862 D 458234 CDS YP_001427852.1 156501787 5524199 365905..368217 1 NC_009749.1 multifunctional fusion protein; phosphoribosylaminoimidazole-succinocarboxamide synthase/phosphoribosylamine-glycine ligase 368217 purCD 5524199 purCD Francisella tularensis subsp. holarctica FTNF002-00 phosphoribosylaminoimidazole-succinocarboxamide synthase/phosphoribosylamine-glycine ligase YP_001427852.1 365905 D 458234 CDS YP_001427853.1 156501788 5524200 368221..368796 1 NC_009749.1 phosphoribosylglycinamide formyltransferase 368796 purN 5524200 purN Francisella tularensis subsp. holarctica FTNF002-00 phosphoribosylglycinamide formyltransferase YP_001427853.1 368221 D 458234 CDS YP_001427854.1 156501789 5524202 368913..369404 1 NC_009749.1 phosphoribosylaminoimidazole carboxylase catalytic subunit 369404 purE 5524202 purE Francisella tularensis subsp. holarctica FTNF002-00 phosphoribosylaminoimidazole carboxylase catalytic subunit YP_001427854.1 368913 D 458234 CDS YP_001427855.1 156501790 5524201 369408..370505 1 NC_009749.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 370505 purK 5524201 purK Francisella tularensis subsp. holarctica FTNF002-00 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_001427855.1 369408 D 458234 CDS YP_001427856.1 156501791 5523574 complement(370682..371335) 1 NC_009749.1 N-terminal truncated due to in-frame stop; transposase, ISFTu2 371335 5523574 FTA_0423 Francisella tularensis subsp. holarctica FTNF002-00 transposase, ISFTu2 YP_001427856.1 370682 R 458234 CDS YP_001427858.1 156501793 5523576 371942..372472 1 NC_009749.1 intracellular septation protein A family protein 372472 ispZ 5523576 ispZ Francisella tularensis subsp. holarctica FTNF002-00 intracellular septation protein A family protein YP_001427858.1 371942 D 458234 CDS YP_001427859.1 156501794 5523577 complement(372786..373802) 1 NC_009749.1 glucokinase 373802 glk 5523577 glk Francisella tularensis subsp. holarctica FTNF002-00 glucokinase YP_001427859.1 372786 R 458234 CDS YP_001427860.1 156501795 5523578 373896..374648 1 NC_009749.1 menaquinone biosynthesis methyltransferase 374648 ubiE 5523578 ubiE Francisella tularensis subsp. holarctica FTNF002-00 menaquinone biosynthesis methyltransferase YP_001427860.1 373896 D 458234 CDS YP_001427861.1 156501796 5523579 374650..375237 1 NC_009749.1 hypothetical protein 375237 5523579 FTA_0428 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427861.1 374650 D 458234 CDS YP_001427862.2 169656520 5523580 375230..376888 1 NC_009749.1 2-polyprenylphenol 6-hydroxylase 376888 ubiB 5523580 ubiB Francisella tularensis subsp. holarctica FTNF002-00 2-polyprenylphenol 6-hydroxylase YP_001427862.2 375230 D 458234 CDS YP_001427863.1 156501798 5523581 376894..377232 1 NC_009749.1 histidine triad domain-containing protein 377232 5523581 FTA_0430 Francisella tularensis subsp. holarctica FTNF002-00 histidine triad domain-containing protein YP_001427863.1 376894 D 458234 CDS YP_001427864.1 156501799 5523582 complement(377249..377380) 1 NC_009749.1 hypothetical protein 377380 5523582 FTA_0431 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427864.1 377249 R 458234 CDS YP_001427865.1 156501800 5523583 complement(377747..378400) 1 NC_009749.1 amidophosphoribosyltransferase/comF family protein 378400 5523583 FTA_0432 Francisella tularensis subsp. holarctica FTNF002-00 amidophosphoribosyltransferase/comF family protein YP_001427865.1 377747 R 458234 CDS YP_001427866.1 156501801 5523584 378378..379205 1 NC_009749.1 hypothetical protein 379205 5523584 FTA_0433 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427866.1 378378 D 458234 CDS YP_001427867.1 156501802 5523585 complement(379207..380082) 1 NC_009749.1 hypothetical protein 380082 5523585 FTA_0434 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427867.1 379207 R 458234 CDS YP_001427868.1 156501803 5523587 complement(380161..381009) 1 NC_009749.1 UDP-N-acetylenolpyruvoylglucosamine reductase 381009 murB 5523587 murB Francisella tularensis subsp. holarctica FTNF002-00 UDP-N-acetylenolpyruvoylglucosamine reductase YP_001427868.1 380161 R 458234 CDS YP_001427869.1 156501804 5523586 complement(381017..382321) 1 NC_009749.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase 382321 murA 5523586 murA Francisella tularensis subsp. holarctica FTNF002-00 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_001427869.1 381017 R 458234 CDS YP_001427870.1 156501805 5523172 complement(382290..383687) 1 NC_009749.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 383687 engA 5523172 engA Francisella tularensis subsp. holarctica FTNF002-00 GTP-binding protein EngA YP_001427870.1 382290 R 458234 CDS YP_001427871.1 156501806 5523173 complement(383924..384442) 1 NC_009749.1 hypothetical protein 384442 5523173 FTA_0438 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427871.1 383924 R 458234 CDS YP_001427872.1 156501807 5523174 384669..385508 1 NC_009749.1 N-terminal truncated due to in-frame stop; transposase, ISFTu2 385508 5523174 FTA_0439 Francisella tularensis subsp. holarctica FTNF002-00 transposase, ISFTu2 YP_001427872.1 384669 D 458234 CDS YP_001427875.1 156501810 5523177 complement(386505..388511) 1 NC_009749.1 M3 family oligopeptidase 388511 5523177 FTA_0442 Francisella tularensis subsp. holarctica FTNF002-00 M3 family oligopeptidase YP_001427875.1 386505 R 458234 CDS YP_001427876.1 156501811 5523178 388603..388974 1 NC_009749.1 hypothetical protein 388974 5523178 FTA_0443 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427876.1 388603 D 458234 CDS YP_001427877.1 156501812 5523179 389055..389504 1 NC_009749.1 lipoprotein 389504 5523179 FTA_0444 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001427877.1 389055 D 458234 CDS YP_001427878.2 169656521 5523180 390165..390668 1 NC_009749.1 hypothetical protein 390668 5523180 FTA_0445 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427878.2 390165 D 458234 CDS YP_001427879.2 169656522 5523181 390701..391168 1 NC_009749.1 lipoprotein 391168 5523181 FTA_0446 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001427879.2 390701 D 458234 CDS YP_001427880.1 156501815 5523182 391241..392683 1 NC_009749.1 O antigen polymerase 392683 5523182 FTA_0447 Francisella tularensis subsp. holarctica FTNF002-00 O antigen polymerase YP_001427880.1 391241 D 458234 CDS YP_001427881.1 156501816 5523183 complement(392737..395031) 1 NC_009749.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining; maintains net negative superhelicity; DNA topoisomerase I 395031 topA 5523183 topA Francisella tularensis subsp. holarctica FTNF002-00 DNA topoisomerase I YP_001427881.1 392737 R 458234 CDS YP_001427882.1 156501817 5523185 395230..395871 1 NC_009749.1 ParA domain-containing protein 395871 5523185 FTA_0449 Francisella tularensis subsp. holarctica FTNF002-00 ParA domain-containing protein YP_001427882.1 395230 D 458234 CDS YP_001427883.2 169656523 5523184 395864..396778 1 NC_009749.1 parB-like nuclease domain-containing protein 396778 5523184 FTA_0450 Francisella tularensis subsp. holarctica FTNF002-00 parB-like nuclease domain-containing protein YP_001427883.2 395864 D 458234 CDS YP_001427884.1 156501819 5524073 396792..397499 1 NC_009749.1 glutamine amidotransferase 397499 5524073 FTA_0451 Francisella tularensis subsp. holarctica FTNF002-00 glutamine amidotransferase YP_001427884.1 396792 D 458234 CDS YP_001427885.1 156501820 5524074 397502..398383 1 NC_009749.1 hypothetical protein 398383 5524074 FTA_0452 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427885.1 397502 D 458234 CDS YP_001427888.1 156501823 5524077 complement(399030..399650) 1 NC_009749.1 ribosomal large subunit methyltransferase J 399650 rrmJ 5524077 rrmJ Francisella tularensis subsp. holarctica FTNF002-00 ribosomal large subunit methyltransferase J YP_001427888.1 399030 R 458234 CDS YP_001427889.2 169656524 5524078 399808..400275 1 NC_009749.1 hypothetical protein 400275 5524078 FTA_0457 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427889.2 399808 D 458234 CDS YP_001427890.1 156501824 5524079 complement(400270..400734) 1 NC_009749.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 400734 lspA 5524079 lspA Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein signal peptidase YP_001427890.1 400270 R 458234 CDS YP_001427891.1 156501826 5524081 complement(400742..403549) 1 NC_009749.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 403549 ileS 5524081 ileS Francisella tularensis subsp. holarctica FTNF002-00 isoleucyl-tRNA synthetase YP_001427891.1 400742 R 458234 CDS YP_001427892.1 156501827 5524080 complement(403642..404562) 1 NC_009749.1 riboflavin biosynthesis protein RibF 404562 ribF 5524080 ribF Francisella tularensis subsp. holarctica FTNF002-00 riboflavin biosynthesis protein RibF YP_001427892.1 403642 R 458234 CDS YP_001427893.1 156501828 5524082 404713..406527 1 NC_009749.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 406527 5524082 FTA_0460 Francisella tularensis subsp. holarctica FTNF002-00 malate dehydrogenase YP_001427893.1 404713 D 458234 CDS YP_001427894.1 156501829 5524083 406693..408363 1 NC_009749.1 lipoprotein 408363 5524083 FTA_0461 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001427894.1 406693 D 458234 CDS YP_001427895.1 156501830 5524084 408380..409825 1 NC_009749.1 hypothetical protein 409825 5524084 FTA_0462 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427895.1 408380 D 458234 CDS YP_001427896.2 169656525 5524086 join(409944..410273,410273..410773) 1 NC_009749.1 programmed ribosomal frameshift; transposase, ISFTu1 410773 5524086 FTA_0463 Francisella tularensis subsp. holarctica FTNF002-00 transposase, ISFTu1 YP_001427896.2 409944 D 458234 CDS YP_001427899.1 156501835 5523633 411940..412542 1 NC_009749.1 hypothetical protein 412542 5523633 FTA_0467 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427899.1 411940 D 458234 CDS YP_001427900.1 156501834 5523634 complement(412539..413762) 1 NC_009749.1 major facilitator transporter 413762 5523634 FTA_0466 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001427900.1 412539 R 458234 CDS YP_001427901.2 169656526 5523636 complement(413779..415803) 1 NC_009749.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 415803 metG 5523636 metG Francisella tularensis subsp. holarctica FTNF002-00 methionyl-tRNA synthetase YP_001427901.2 413779 R 458234 CDS YP_001427902.1 156501837 5524656 complement(416373..416909) 1 NC_009749.1 FMN reductase, NADPH-dependent 416909 5524656 FTA_0469 Francisella tularensis subsp. holarctica FTNF002-00 FMN reductase, NADPH-dependent YP_001427902.1 416373 R 458234 CDS YP_001427905.1 156501840 5523640 complement(423679..424734) 1 NC_009749.1 extracellular ligand binding domain-containing protein 424734 5523640 FTA_0473 Francisella tularensis subsp. holarctica FTNF002-00 extracellular ligand binding domain-containing protein YP_001427905.1 423679 R 458234 CDS YP_001427906.2 169656527 5523641 complement(424848..425504) 1 NC_009749.1 M50 family peptidase 425504 5523641 FTA_0474 Francisella tularensis subsp. holarctica FTNF002-00 M50 family peptidase YP_001427906.2 424848 R 458234 CDS YP_001427907.1 156501842 5523642 425757..425885 1 NC_009749.1 hypothetical protein 425885 5523642 FTA_0475 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427907.1 425757 D 458234 CDS YP_001427908.1 156501844 5523643 426708..427043 1 NC_009749.1 hypothetical protein 427043 5523643 FTA_0477 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427908.1 426708 D 458234 CDS YP_001427909.1 156501843 5523645 complement(427016..427867) 1 NC_009749.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 427867 psd 5523645 psd Francisella tularensis subsp. holarctica FTNF002-00 phosphatidylserine decarboxylase YP_001427909.1 427016 R 458234 CDS YP_001427910.2 169656528 5523644 427967..428947 1 NC_009749.1 hypothetical protein 428947 5523644 FTA_0478 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427910.2 427967 D 458234 CDS YP_001427911.1 156501846 5522917 428956..429999 1 NC_009749.1 NadM-Nudix subfamily; involved in creation of nicotanimide adenine dinucleotide NAD from either biosynthetic or salvage pathways; bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase 429999 5522917 FTA_0479 Francisella tularensis subsp. holarctica FTNF002-00 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase YP_001427911.1 428956 D 458234 CDS YP_001427912.1 156501847 5522918 430013..431380 1 NC_009749.1 UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase 431380 glmU 5522918 glmU Francisella tularensis subsp. holarctica FTNF002-00 UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase YP_001427912.1 430013 D 458234 CDS YP_001427913.1 156501848 5522919 431401..433239 1 NC_009749.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 433239 glmS 5522919 glmS Francisella tularensis subsp. holarctica FTNF002-00 glucosamine--fructose-6-phosphate aminotransferase YP_001427913.1 431401 D 458234 CDS YP_001427914.2 169656529 5522920 433323..433844 1 NC_009749.1 acetyltransferase 433844 5522920 FTA_0483 Francisella tularensis subsp. holarctica FTNF002-00 acetyltransferase YP_001427914.2 433323 D 458234 CDS YP_001427915.1 156501849 5522922 complement(433841..434038) 1 NC_009749.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 434038 rpsU 5522922 rpsU Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S21 YP_001427915.1 433841 R 458234 CDS YP_001427916.1 156501851 5522921 complement(434038..434241) 1 NC_009749.1 cold-shock DNA-binding domain-containing protein 434241 5522921 FTA_0484 Francisella tularensis subsp. holarctica FTNF002-00 cold-shock DNA-binding domain-containing protein YP_001427916.1 434038 R 458234 CDS YP_001427917.1 156501852 5522923 complement(434488..434817) 1 NC_009749.1 MazG nucleotide pyrophosphohydrolase domain-containing protein 434817 5522923 FTA_0485 Francisella tularensis subsp. holarctica FTNF002-00 MazG nucleotide pyrophosphohydrolase domain-containing protein YP_001427917.1 434488 R 458234 CDS YP_001427918.1 156501853 5522924 434944..435714 1 NC_009749.1 methionine aminopeptidase 435714 map 5522924 map Francisella tularensis subsp. holarctica FTNF002-00 methionine aminopeptidase YP_001427918.1 434944 D 458234 CDS YP_001427919.1 156501854 5522925 435716..436564 1 NC_009749.1 hypothetical protein 436564 5522925 FTA_0487 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427919.1 435716 D 458234 CDS YP_001427920.1 156501855 5522926 436649..437323 1 NC_009749.1 DNA repair ATPase 437323 5522926 FTA_0488 Francisella tularensis subsp. holarctica FTNF002-00 DNA repair ATPase YP_001427920.1 436649 D 458234 CDS YP_001427921.2 169656530 5522927 437456..439681 1 NC_009749.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 439681 parC 5522927 parC Francisella tularensis subsp. holarctica FTNF002-00 DNA topoisomerase IV subunit A YP_001427921.2 437456 D 458234 CDS YP_001427922.1 156501858 5522928 439681..440367 1 NC_009749.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 440367 mtnN 5522928 mtnN Francisella tularensis subsp. holarctica FTNF002-00 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_001427922.1 439681 D 458234 CDS YP_001427923.1 156501857 5522930 complement(440354..440953) 1 NC_009749.1 hypothetical protein 440953 5522930 FTA_0490 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427923.1 440354 R 458234 CDS YP_001427924.1 156501859 5522929 complement(440946..442064) 1 NC_009749.1 BNR/Asp-box repeat-containing neuramidase 442064 5522929 FTA_0492 Francisella tularensis subsp. holarctica FTNF002-00 BNR/Asp-box repeat-containing neuramidase YP_001427924.1 440946 R 458234 CDS YP_001427925.1 156501860 5523202 442296..444239 1 NC_009749.1 lytic murein transglycosylase 444239 5523202 FTA_0493 Francisella tularensis subsp. holarctica FTNF002-00 lytic murein transglycosylase YP_001427925.1 442296 D 458234 CDS YP_001427928.2 169656531 5523205 446102..446485 1 NC_009749.1 hypothetical protein 446485 5523205 FTA_0496 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427928.2 446102 D 458234 CDS YP_001427930.1 156501865 5523207 447613..451092 1 NC_009749.1 DNA polymerase III subunit alpha 451092 dnaE 5523207 dnaE Francisella tularensis subsp. holarctica FTNF002-00 DNA polymerase III subunit alpha YP_001427930.1 447613 D 458234 CDS YP_001427931.1 156501866 5523208 451171..451803 1 NC_009749.1 peptide deformylase 451803 def2 5523208 def2 Francisella tularensis subsp. holarctica FTNF002-00 peptide deformylase YP_001427931.1 451171 D 458234 CDS YP_001427932.1 156501867 5524151 452466..453770 1 NC_009749.1 LolC/E family lipoprotein releasing system, transmembrane protein 453770 5524151 FTA_0500 Francisella tularensis subsp. holarctica FTNF002-00 LolC/E family lipoprotein releasing system, transmembrane protein YP_001427932.1 452466 D 458234 CDS YP_001427933.1 156501868 5523210 453763..454458 1 NC_009749.1 lipoprotein-releasing system, ATP-binding protein 454458 lolD 5523210 lolD Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein-releasing system, ATP-binding protein YP_001427933.1 453763 D 458234 CDS YP_001427934.1 156501869 5523211 454575..456716 1 NC_009749.1 Orn/Lys/Arg decarboxylase 456716 5523211 FTA_0502 Francisella tularensis subsp. holarctica FTNF002-00 Orn/Lys/Arg decarboxylase YP_001427934.1 454575 D 458234 CDS YP_001427935.1 156501870 5523212 456808..457884 1 NC_009749.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 457884 gcvT 5523212 gcvT Francisella tularensis subsp. holarctica FTNF002-00 glycine cleavage system aminomethyltransferase T YP_001427935.1 456808 D 458234 CDS YP_001427936.1 156501871 5523213 457941..458324 1 NC_009749.1 glycine cleavage system H protein 458324 gcvH1 5523213 gcvH1 Francisella tularensis subsp. holarctica FTNF002-00 glycine cleavage system H protein YP_001427936.1 457941 D 458234 CDS YP_001427937.1 156501872 5523214 458389..459756 1 NC_009749.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein; glycine dehydrogenase subunit 1 459756 gcvP1 5523214 gcvP1 Francisella tularensis subsp. holarctica FTNF002-00 glycine dehydrogenase subunit 1 YP_001427937.1 458389 D 458234 CDS YP_001427938.1 156501873 5523215 459762..461207 1 NC_009749.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; glycine dehydrogenase subunit 2 461207 gcvP2 5523215 gcvP2 Francisella tularensis subsp. holarctica FTNF002-00 glycine dehydrogenase subunit 2 YP_001427938.1 459762 D 458234 CDS YP_001427939.1 156501874 5522903 complement(461327..462172) 1 NC_009749.1 shikimate 5-dehydrogenase 462172 5522903 FTA_0507 Francisella tularensis subsp. holarctica FTNF002-00 shikimate 5-dehydrogenase YP_001427939.1 461327 R 458234 CDS YP_001427940.1 156501875 5522904 complement(462198..465410) 1 NC_009749.1 pullulanase Type I 465410 pulA 5522904 pulA Francisella tularensis subsp. holarctica FTNF002-00 pullulanase Type I YP_001427940.1 462198 R 458234 CDS YP_001427941.1 156501876 5522905 complement(465444..467366) 1 NC_009749.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 467366 glgB 5522905 glgB Francisella tularensis subsp. holarctica FTNF002-00 glycogen branching protein YP_001427941.1 465444 R 458234 CDS YP_001427942.1 156501877 5522906 467668..469302 1 NC_009749.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 469302 5522906 FTA_0510 Francisella tularensis subsp. holarctica FTNF002-00 phosphoglucomutase YP_001427942.1 467668 D 458234 CDS YP_001427943.1 156501878 5522907 469336..470607 1 NC_009749.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 470607 glgC 5522907 glgC Francisella tularensis subsp. holarctica FTNF002-00 glucose-1-phosphate adenylyltransferase YP_001427943.1 469336 D 458234 CDS YP_001427944.1 156501879 5522908 470617..472086 1 NC_009749.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 472086 glgA 5522908 glgA Francisella tularensis subsp. holarctica FTNF002-00 glycogen synthase YP_001427944.1 470617 D 458234 CDS YP_001427945.1 156501880 5522909 472191..474464 1 NC_009749.1 glycogen/starch/alpha-glucan phosphorylase 474464 glgP 5522909 glgP Francisella tularensis subsp. holarctica FTNF002-00 glycogen/starch/alpha-glucan phosphorylase YP_001427945.1 472191 D 458234 CDS YP_001427946.2 169656532 5522910 474508..475971 1 NC_009749.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 475971 malQ 5522910 malQ Francisella tularensis subsp. holarctica FTNF002-00 4-alpha-glucanotransferase YP_001427946.2 474508 D 458234 CDS YP_001427947.1 156501882 5522911 476063..476953 1 NC_009749.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 476953 glyQ 5522911 glyQ Francisella tularensis subsp. holarctica FTNF002-00 glycyl-tRNA synthetase subunit alpha YP_001427947.1 476063 D 458234 CDS YP_001427948.1 156501883 5522912 477164..478627 1 NC_009749.1 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 478627 5522912 FTA_0516 Francisella tularensis subsp. holarctica FTNF002-00 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_001427948.1 477164 D 458234 CDS YP_001427949.1 156501884 5522913 478649..479044 1 NC_009749.1 lipoprotein 479044 5522913 FTA_0517 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001427949.1 478649 D 458234 CDS YP_001427950.1 156501885 5522914 479397..480755 1 NC_009749.1 UDP-N--acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase 480755 5522914 FTA_0518 Francisella tularensis subsp. holarctica FTNF002-00 UDP-N--acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase YP_001427950.1 479397 D 458234 CDS YP_001427951.1 156501886 5522915 480764..481582 1 NC_009749.1 hypothetical protein 481582 5522915 FTA_0519 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427951.1 480764 D 458234 CDS YP_001427952.1 156501887 5522916 complement(481631..482671) 1 NC_009749.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 482671 asd 5522916 asd Francisella tularensis subsp. holarctica FTNF002-00 aspartate-semialdehyde dehydrogenase YP_001427952.1 481631 R 458234 CDS YP_001427953.1 156501888 5523845 482970..483827 1 NC_009749.1 N-terminal and C-terminal truncation comapred to other Francisella species; amino acid kinase family protein 483827 5523845 FTA_0521 Francisella tularensis subsp. holarctica FTNF002-00 amino acid kinase family protein YP_001427953.1 482970 D 458234 CDS YP_001427954.1 156501889 5523846 483988..484638 1 NC_009749.1 N-terminal truncation comapred to other Francisella species; putative GHMP kinases ATP-binding protein 484638 5523846 FTA_0522 Francisella tularensis subsp. holarctica FTNF002-00 putative GHMP kinases ATP-binding protein YP_001427954.1 483988 D 458234 CDS YP_001427955.1 156501890 5523847 484651..485943 1 NC_009749.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 485943 thrC 5523847 thrC Francisella tularensis subsp. holarctica FTNF002-00 threonine synthase YP_001427955.1 484651 D 458234 CDS YP_001427956.1 156501891 5523848 486531..487019 1 NC_009749.1 S-adenosylmethionine decarboxylase 487019 5523848 FTA_0524 Francisella tularensis subsp. holarctica FTNF002-00 S-adenosylmethionine decarboxylase YP_001427956.1 486531 D 458234 CDS YP_001427957.1 156501892 5523849 487019..487888 1 NC_009749.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 487888 speE 5523849 speE Francisella tularensis subsp. holarctica FTNF002-00 spermidine synthase YP_001427957.1 487019 D 458234 CDS YP_001427961.2 169656533 5523853 complement(join(490405..490956,490956..491285)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 491285 5523853 FTA_0529 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427961.2 490405 R 458234 CDS YP_001427966.1 156501901 5523858 complement(492359..493075) 1 NC_009749.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 493075 lpxH 5523858 lpxH Francisella tularensis subsp. holarctica FTNF002-00 UDP-2,3-diacylglucosamine hydrolase YP_001427966.1 492359 R 458234 CDS YP_001427967.1 156501902 5522642 complement(493065..493775) 1 NC_009749.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 493775 pyrE 5522642 pyrE Francisella tularensis subsp. holarctica FTNF002-00 orotate phosphoribosyltransferase YP_001427967.1 493065 R 458234 CDS YP_001427968.1 156501903 5522643 493851..495221 1 NC_009749.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 495221 mpl 5522643 mpl Francisella tularensis subsp. holarctica FTNF002-00 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase YP_001427968.1 493851 D 458234 CDS YP_001427969.1 156501905 5522644 495218..495874 1 NC_009749.1 RNA methyltransferase 495874 5522644 FTA_0538 Francisella tularensis subsp. holarctica FTNF002-00 RNA methyltransferase YP_001427969.1 495218 D 458234 CDS YP_001427970.2 169656534 5522646 complement(join(495852..496403,496403..496732)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 496732 5522646 FTA_0537 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427970.2 495852 R 458234 CDS YP_001427973.1 156501908 5522648 complement(497942..498178) 1 NC_009749.1 BolA -like protein 498178 5522648 FTA_0541 Francisella tularensis subsp. holarctica FTNF002-00 BolA -like protein YP_001427973.1 497942 R 458234 CDS YP_001427974.1 156501909 5522649 complement(498195..498488) 1 NC_009749.1 hypothetical protein 498488 5522649 FTA_0542 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427974.1 498195 R 458234 CDS YP_001427975.2 169656535 5522650 complement(498488..499150) 1 NC_009749.1 organic solvent resistance ABC transporter 499150 ttg2 5522650 ttg2 Francisella tularensis subsp. holarctica FTNF002-00 organic solvent resistance ABC transporter YP_001427975.2 498488 R 458234 CDS YP_001427976.2 169656536 5522651 complement(499225..499758) 1 NC_009749.1 ABC transporter periplasmic protein 499758 5522651 FTA_0544 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter periplasmic protein YP_001427976.2 499225 R 458234 CDS YP_001427977.2 169656537 5522652 complement(499758..500522) 1 NC_009749.1 toluene tolerance protein 500522 ttg2B 5522652 ttg2B Francisella tularensis subsp. holarctica FTNF002-00 toluene tolerance protein YP_001427977.2 499758 R 458234 CDS YP_001427978.1 156501913 5522653 complement(500526..501329) 1 NC_009749.1 ABC transporter ATP-binding protein 501329 5522653 FTA_0546 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter ATP-binding protein YP_001427978.1 500526 R 458234 CDS YP_001427979.1 156501914 5522654 complement(501343..501615) 1 NC_009749.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 501615 minE 5522654 minE Francisella tularensis subsp. holarctica FTNF002-00 cell division topological specificity factor MinE YP_001427979.1 501343 R 458234 CDS YP_001427980.1 156501915 5524157 complement(501618..502442) 1 NC_009749.1 septum site-determining protein MinD 502442 minD 5524157 minD Francisella tularensis subsp. holarctica FTNF002-00 septum site-determining protein MinD YP_001427980.1 501618 R 458234 CDS YP_001427981.1 156501916 5522529 complement(502482..503168) 1 NC_009749.1 septum site-determining protein MinC 503168 minC 5522529 minC Francisella tularensis subsp. holarctica FTNF002-00 septum site-determining protein MinC YP_001427981.1 502482 R 458234 CDS YP_001427982.1 156501917 5522530 complement(503203..503358) 1 NC_009749.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 503358 rpmG 5522530 rpmG Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L33 YP_001427982.1 503203 R 458234 CDS YP_001427983.1 156501918 5522531 complement(503385..503621) 1 NC_009749.1 required for 70S ribosome assembly; 50S ribosomal protein L28 503621 rpmB 5522531 rpmB Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L28 YP_001427983.1 503385 R 458234 CDS YP_001427984.1 156501919 5522532 complement(503755..504099) 1 NC_009749.1 hypothetical protein 504099 5522532 FTA_0552 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427984.1 503755 R 458234 CDS YP_001427985.1 156501920 5522533 504229..506268 1 NC_009749.1 ATP-dependent DNA helicase RecG 506268 5522533 FTA_0553 Francisella tularensis subsp. holarctica FTNF002-00 ATP-dependent DNA helicase RecG YP_001427985.1 504229 D 458234 CDS YP_001427986.1 156501921 5522534 506326..506469 1 NC_009749.1 hypothetical protein 506469 5522534 FTA_0554 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427986.1 506326 D 458234 CDS YP_001427987.1 156501922 5522535 507023..508537 1 NC_009749.1 fumerate hydratase 508537 5522535 FTA_0555 Francisella tularensis subsp. holarctica FTNF002-00 fumerate hydratase YP_001427987.1 507023 D 458234 CDS YP_001427988.1 156501923 5522536 508541..508681 1 NC_009749.1 hypothetical protein 508681 5522536 FTA_0556 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001427988.1 508541 D 458234 CDS YP_001427989.2 169656538 5522537 join(509021..509350,509350..509739) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 509739 5522537 FTA_0557 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001427989.2 509021 D 458234 CDS YP_001427991.1 156501926 5522539 509744..510028 1 NC_009749.1 endonuclease 510028 5522539 FTA_0559 Francisella tularensis subsp. holarctica FTNF002-00 endonuclease YP_001427991.1 509744 D 458234 CDS YP_001427992.1 156501927 5522540 510266..513139 1 NC_009749.1 type III restriction enzyme 513139 5522540 FTA_0560 Francisella tularensis subsp. holarctica FTNF002-00 type III restriction enzyme YP_001427992.1 510266 D 458234 CDS YP_001427993.1 156501928 5522541 513136..513798 1 NC_009749.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 513798 ung 5522541 ung Francisella tularensis subsp. holarctica FTNF002-00 uracil-DNA glycosylase YP_001427993.1 513136 D 458234 CDS YP_001427998.1 156501933 5523764 515754..518360 1 NC_009749.1 DNA gyrase subunit A 518360 gyrA 5523764 gyrA Francisella tularensis subsp. holarctica FTNF002-00 DNA gyrase subunit A YP_001427998.1 515754 D 458234 CDS YP_001427999.1 156501934 5523765 518366..519523 1 NC_009749.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 519523 dxr 5523765 dxr Francisella tularensis subsp. holarctica FTNF002-00 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_001427999.1 518366 D 458234 CDS YP_001428000.2 169656539 5523766 519529..521907 1 NC_009749.1 outer membrane protein 521907 5523766 FTA_0568 Francisella tularensis subsp. holarctica FTNF002-00 outer membrane protein YP_001428000.2 519529 D 458234 CDS YP_001428001.1 156501936 5523767 522043..522546 1 NC_009749.1 outer membrane protein OmpH 522546 5523767 FTA_0569 Francisella tularensis subsp. holarctica FTNF002-00 outer membrane protein OmpH YP_001428001.1 522043 D 458234 CDS YP_001428002.1 156501937 5523768 522565..523578 1 NC_009749.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 523578 lpxD 5523768 lpxD Francisella tularensis subsp. holarctica FTNF002-00 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_001428002.1 522565 D 458234 CDS YP_001428003.1 156501938 5523769 523593..524084 1 NC_009749.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 524084 fabZ 5523769 fabZ Francisella tularensis subsp. holarctica FTNF002-00 (3R)-hydroxymyristoyl-ACP dehydratase YP_001428003.1 523593 D 458234 CDS YP_001428004.1 156501939 5523770 524087..524866 1 NC_009749.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 524866 lpxA 5523770 lpxA Francisella tularensis subsp. holarctica FTNF002-00 UDP-N-acetylglucosamine acyltransferase YP_001428004.1 524087 D 458234 CDS YP_001428005.1 156501940 5523771 524866..526008 1 NC_009749.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 526008 lpxB 5523771 lpxB Francisella tularensis subsp. holarctica FTNF002-00 lipid-A-disaccharide synthase YP_001428005.1 524866 D 458234 CDS YP_001428006.1 156501941 5523772 526067..526654 1 NC_009749.1 hypothetical protein 526654 5523772 FTA_0574 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428006.1 526067 D 458234 CDS YP_001428007.1 156501942 5523773 526745..527119 1 NC_009749.1 hypothetical protein 527119 5523773 FTA_0575 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428007.1 526745 D 458234 CDS YP_001428008.1 156501943 5523774 527526..528569 1 NC_009749.1 glycosyl hydrolase family protein 528569 5523774 FTA_0576 Francisella tularensis subsp. holarctica FTNF002-00 glycosyl hydrolase family protein YP_001428008.1 527526 D 458234 CDS YP_001428009.1 156501944 5524222 complement(528940..529749) 1 NC_009749.1 hypothetical protein 529749 5524222 FTA_0577 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428009.1 528940 R 458234 CDS YP_001428010.1 156501945 5523891 complement(529819..530583) 1 NC_009749.1 phosphatidylcholine synthase 530583 5523891 FTA_0578 Francisella tularensis subsp. holarctica FTNF002-00 phosphatidylcholine synthase YP_001428010.1 529819 R 458234 CDS YP_001428011.2 169656540 5523892 complement(530631..531512) 1 NC_009749.1 polyprenyl synthetase 531512 5523892 FTA_0579 Francisella tularensis subsp. holarctica FTNF002-00 polyprenyl synthetase YP_001428011.2 530631 R 458234 CDS YP_001428012.1 156501947 5523893 complement(531509..532804) 1 NC_009749.1 3-deoxy-D-manno-octulosonic-acid transferase 532804 5523893 FTA_0580 Francisella tularensis subsp. holarctica FTNF002-00 3-deoxy-D-manno-octulosonic-acid transferase YP_001428012.1 531509 R 458234 CDS YP_001428013.1 156501948 5523894 complement(532909..533487) 1 NC_009749.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 533487 rdgB 5523894 rdgB Francisella tularensis subsp. holarctica FTNF002-00 putative deoxyribonucleotide triphosphate pyrophosphatase YP_001428013.1 532909 R 458234 CDS YP_001428014.1 156501949 5523895 533594..534418 1 NC_009749.1 pyrroline-5-carboxylate reductase 534418 proC 5523895 proC Francisella tularensis subsp. holarctica FTNF002-00 pyrroline-5-carboxylate reductase YP_001428014.1 533594 D 458234 CDS YP_001428017.1 156501952 5523898 536176..536862 1 NC_009749.1 two-component response regulator 536862 5523898 FTA_0585 Francisella tularensis subsp. holarctica FTNF002-00 two-component response regulator YP_001428017.1 536176 D 458234 CDS YP_001428018.1 156501953 5523899 536867..537730 1 NC_009749.1 signal peptidase I 537730 lepB 5523899 lepB Francisella tularensis subsp. holarctica FTNF002-00 signal peptidase I YP_001428018.1 536867 D 458234 CDS YP_001428019.1 156501954 5523900 537737..538429 1 NC_009749.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 538429 rnc 5523900 rnc Francisella tularensis subsp. holarctica FTNF002-00 ribonuclease III YP_001428019.1 537737 D 458234 CDS YP_001428020.1 156501955 5523901 538416..539324 1 NC_009749.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 539324 truB 5523901 truB Francisella tularensis subsp. holarctica FTNF002-00 tRNA pseudouridine synthase B YP_001428020.1 538416 D 458234 CDS YP_001428021.1 156501956 5523902 539398..541569 1 NC_009749.1 ribonuclease R 541569 rnr 5523902 rnr Francisella tularensis subsp. holarctica FTNF002-00 ribonuclease R YP_001428021.1 539398 D 458234 CDS YP_001428022.1 156501957 5523903 complement(541637..542329) 1 NC_009749.1 missing N-terminal residues comapred to Schu4 and WY96-3418; fatty acid desaturase 542329 5523903 FTA_0590 Francisella tularensis subsp. holarctica FTNF002-00 fatty acid desaturase YP_001428022.1 541637 R 458234 CDS YP_001428023.1 156501958 5524537 complement(542480..543223) 1 NC_009749.1 short chain dehydrogenase/reductase family oxidoreductase 543223 5524537 FTA_0591 Francisella tularensis subsp. holarctica FTNF002-00 short chain dehydrogenase/reductase family oxidoreductase YP_001428023.1 542480 R 458234 CDS YP_001428024.1 156501959 5524538 complement(543225..543767) 1 NC_009749.1 hypothetical protein 543767 5524538 FTA_0592 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428024.1 543225 R 458234 CDS YP_001428025.2 169656541 5524539 complement(543764..544273) 1 NC_009749.1 hypothetical protein 544273 5524539 FTA_0593 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428025.2 543764 R 458234 CDS YP_001428026.1 156501961 5524540 complement(544266..545360) 1 NC_009749.1 missing N-terminal residues compared to WY96-3418 ORF; cyclopropane-fatty-acyl-phospholipid synthase 545360 5524540 FTA_0594 Francisella tularensis subsp. holarctica FTNF002-00 cyclopropane-fatty-acyl-phospholipid synthase YP_001428026.1 544266 R 458234 CDS YP_001428029.1 156501964 5524543 complement(546316..547371) 1 NC_009749.1 hypothetical protein 547371 5524543 FTA_0597 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428029.1 546316 R 458234 CDS YP_001428034.1 156501969 5524548 complement(549203..549823) 1 NC_009749.1 transposase ISFTu2 549823 5524548 FTA_0602 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428034.1 549203 R 458234 CDS YP_001428035.1 156501970 5524549 550137..550673 1 NC_009749.1 hypothetical protein 550673 5524549 FTA_0603 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428035.1 550137 D 458234 CDS YP_001428036.1 156501971 5522655 550791..551192 1 NC_009749.1 hypothetical protein 551192 5522655 FTA_0604 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428036.1 550791 D 458234 CDS YP_001428037.1 156501972 5523675 551367..551975 1 NC_009749.1 hypothetical protein 551975 5523675 FTA_0605 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428037.1 551367 D 458234 CDS YP_001428038.1 156501973 5523676 552032..553462 1 NC_009749.1 hypothetical protein 553462 5523676 FTA_0606 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428038.1 552032 D 458234 CDS YP_001428039.1 156501974 5523677 553473..554456 1 NC_009749.1 hypothetical protein 554456 5523677 FTA_0607 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428039.1 553473 D 458234 CDS YP_001428040.2 169656542 5523678 554462..555856 1 NC_009749.1 hypothetical protein 555856 5523678 FTA_0608 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428040.2 554462 D 458234 CDS YP_001428041.1 156501976 5523679 complement(556069..556737) 1 NC_009749.1 N-terminal truncated comapred to Schu4; transposase ISFTu2 556737 5523679 FTA_0609 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428041.1 556069 R 458234 CDS YP_001428044.1 156501979 5523682 558171..559031 1 NC_009749.1 catalyzes the formation of L-proline from L-ornithine; ornithine cyclodeaminase 559031 5523682 FTA_0612 Francisella tularensis subsp. holarctica FTNF002-00 ornithine cyclodeaminase YP_001428044.1 558171 D 458234 CDS YP_001428045.2 169656543 5523683 559102..560517 1 NC_009749.1 putative nicotinate phosphoribosyltransferase 560517 5523683 FTA_0613 Francisella tularensis subsp. holarctica FTNF002-00 putative nicotinate phosphoribosyltransferase YP_001428045.2 559102 D 458234 CDS YP_001428046.1 156501981 5523684 560602..560829 1 NC_009749.1 hypothetical protein 560829 5523684 FTA_0614 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428046.1 560602 D 458234 CDS YP_001428047.2 169656545 5523685 560979..562259 1 NC_009749.1 major facilitator transporter 562259 5523685 FTA_0616 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001428047.2 560979 D 458234 CDS YP_001428048.2 169656544 5523687 complement(562252..562740) 1 NC_009749.1 thioesterase family protein 562740 5523687 FTA_0615 Francisella tularensis subsp. holarctica FTNF002-00 thioesterase family protein YP_001428048.2 562252 R 458234 CDS YP_001428049.1 156501984 5523686 complement(562802..563989) 1 NC_009749.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 563989 5523686 FTA_0617 Francisella tularensis subsp. holarctica FTNF002-00 acetyl-CoA acetyltransferase YP_001428049.1 562802 R 458234 CDS YP_001428050.1 156501985 5524550 complement(564002..566698) 1 NC_009749.1 fusion product of 3-hydroxacyl-CoA dehydrogenase and acyl-CoA-binding protein 566698 5524550 FTA_0618 Francisella tularensis subsp. holarctica FTNF002-00 fusion product of 3-hydroxacyl-CoA dehydrogenase and acyl-CoA-binding protein YP_001428050.1 564002 R 458234 CDS YP_001428051.2 169656546 5524509 complement(566771..569032) 1 NC_009749.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 569032 fadE 5524509 fadE Francisella tularensis subsp. holarctica FTNF002-00 acyl-CoA dehydrogenase YP_001428051.2 566771 R 458234 CDS YP_001428052.1 156501987 5524510 complement(569049..570737) 1 NC_009749.1 putative acyl Co-A synthetase/long chain fatty acid CoA ligase 570737 5524510 FTA_0620 Francisella tularensis subsp. holarctica FTNF002-00 putative acyl Co-A synthetase/long chain fatty acid CoA ligase YP_001428052.1 569049 R 458234 CDS YP_001428053.1 156501988 5524511 570953..571300 1 NC_009749.1 ArsC family arsenate permease 571300 5524511 FTA_0621 Francisella tularensis subsp. holarctica FTNF002-00 ArsC family arsenate permease YP_001428053.1 570953 D 458234 CDS YP_001428054.1 156501989 5524512 571349..573565 1 NC_009749.1 isocitrate dehydrogenase 573565 5524512 FTA_0622 Francisella tularensis subsp. holarctica FTNF002-00 isocitrate dehydrogenase YP_001428054.1 571349 D 458234 CDS YP_001428055.1 156501990 5524513 573579..574466 1 NC_009749.1 hypothetical protein 574466 5524513 FTA_0623 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428055.1 573579 D 458234 CDS YP_001428056.1 156501991 5524514 574486..578820 1 NC_009749.1 ATP-dependent helicase 578820 hrpA 5524514 hrpA Francisella tularensis subsp. holarctica FTNF002-00 ATP-dependent helicase YP_001428056.1 574486 D 458234 CDS YP_001428057.1 156501992 5524515 579354..579974 1 NC_009749.1 transposase ISFTu2 579974 5524515 FTA_0625 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428057.1 579354 D 458234 CDS YP_001428058.2 169656547 5524516 580077..581813 1 NC_009749.1 component of putative O antigen gene cluster; NAD dependent epimerase/dehydratase family protein 581813 5524516 FTA_0626 Francisella tularensis subsp. holarctica FTNF002-00 NAD dependent epimerase/dehydratase family protein YP_001428058.2 580077 D 458234 CDS YP_001428059.1 156501994 5524517 581806..582438 1 NC_009749.1 component of putative O antigen gene cluster; glycosyltransferase 582438 5524517 FTA_0627 Francisella tularensis subsp. holarctica FTNF002-00 glycosyltransferase YP_001428059.1 581806 D 458234 CDS YP_001428060.1 156501995 5524518 582440..583231 1 NC_009749.1 component of putative O antigen gen cluster; NAD-dependent epimerase/dehydratase family protein 583231 wbtC 5524518 wbtC Francisella tularensis subsp. holarctica FTNF002-00 NAD-dependent epimerase/dehydratase family protein YP_001428060.1 582440 D 458234 CDS YP_001428061.1 156501996 5524519 583221..584312 1 NC_009749.1 component of putative O antigen gene cluster; glycosyltransferase group I 584312 wbtD 5524519 wbtD Francisella tularensis subsp. holarctica FTNF002-00 glycosyltransferase group I YP_001428061.1 583221 D 458234 CDS YP_001428062.1 156501997 5524520 584330..585640 1 NC_009749.1 component of putative O antigen gene cluster; UDP-glucose/GDP-mannose dehydrogenase 585640 wbtE 5524520 wbtE Francisella tularensis subsp. holarctica FTNF002-00 UDP-glucose/GDP-mannose dehydrogenase YP_001428062.1 584330 D 458234 CDS YP_001428063.2 169656548 5524521 585628..586611 1 NC_009749.1 component of putative O antigen gene cluster; NAD dependent epimerase/dehydratase family protein 586611 wbtF 5524521 wbtF Francisella tularensis subsp. holarctica FTNF002-00 NAD dependent epimerase/dehydratase family protein YP_001428063.2 585628 D 458234 CDS YP_001428064.1 156501999 5524522 586628..587857 1 NC_009749.1 component of putative O antigen gene cluster; O-antigen polymerase 587857 wzy 5524522 wzy Francisella tularensis subsp. holarctica FTNF002-00 O-antigen polymerase YP_001428064.1 586628 D 458234 CDS YP_001428065.2 169656549 5522686 587854..588954 1 NC_009749.1 component of putative O antigen gene cluster; glycosyltransferase group I 588954 wbtG 5522686 wbtG Francisella tularensis subsp. holarctica FTNF002-00 glycosyltransferase group I YP_001428065.2 587854 D 458234 CDS YP_001428066.1 156502001 5522687 588954..590840 1 NC_009749.1 component of putative antigen O gene complex; asparagine synthase 590840 wbtH 5522687 wbtH Francisella tularensis subsp. holarctica FTNF002-00 asparagine synthase YP_001428066.1 588954 D 458234 CDS YP_001428067.1 156502002 5522688 590833..591915 1 NC_009749.1 component of putative O antigen gene complex; DegT/DnrJ/EryC1/StrS family sugar aminotransferase 591915 wbtI 5522688 wbtI Francisella tularensis subsp. holarctica FTNF002-00 DegT/DnrJ/EryC1/StrS family sugar aminotransferase YP_001428067.1 590833 D 458234 CDS YP_001428068.1 156502003 5522689 591912..592637 1 NC_009749.1 component of putative O antigen gene complex; hypothetical protein 592637 wbtJ 5522689 wbtJ Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428068.1 591912 D 458234 CDS YP_001428069.1 156502004 5522690 592642..594129 1 NC_009749.1 component of putative O antigen gene complex; O-antigen flippase 594129 wzx 5522690 wzx Francisella tularensis subsp. holarctica FTNF002-00 O-antigen flippase YP_001428069.1 592642 D 458234 CDS YP_001428070.2 169656550 5522691 594122..594982 1 NC_009749.1 component of putative O antigen gene complex; glycosyltransferase group 2 family protein 594982 wbtK 5522691 wbtK Francisella tularensis subsp. holarctica FTNF002-00 glycosyltransferase group 2 family protein YP_001428070.2 594122 D 458234 CDS YP_001428071.1 156502006 5522692 595007..595891 1 NC_009749.1 component of putative O antigen gene complex; glucose-1-phosphate thymidylyltransferase 595891 wbtL 5522692 wbtL Francisella tularensis subsp. holarctica FTNF002-00 glucose-1-phosphate thymidylyltransferase YP_001428071.1 595007 D 458234 CDS YP_001428072.2 169656551 5522693 596438..597454 1 NC_009749.1 component of putative O antigen gene complex; dTDP-glucose 4,6-dehydratase 597454 wbtM 5522693 wbtM Francisella tularensis subsp. holarctica FTNF002-00 dTDP-glucose 4,6-dehydratase YP_001428072.2 596438 D 458234 CDS YP_001428073.2 169656552 5522694 join(597599..597928,597928..598479) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 598479 5522694 FTA_0641 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001428073.2 597599 D 458234 CDS YP_001428075.1 156502010 5522696 598732..600138 1 NC_009749.1 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase 600138 5522696 FTA_0643 Francisella tularensis subsp. holarctica FTNF002-00 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase YP_001428075.1 598732 D 458234 CDS YP_001428076.1 156502011 5522697 600169..601653 1 NC_009749.1 phosphoglucomutase/phosphomannomutase 601653 5522697 FTA_0644 Francisella tularensis subsp. holarctica FTNF002-00 phosphoglucomutase/phosphomannomutase YP_001428076.1 600169 D 458234 CDS YP_001428077.1 156502012 5522698 complement(602746..604008) 1 NC_009749.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 604008 rho 5522698 rho Francisella tularensis subsp. holarctica FTNF002-00 transcription termination factor Rho YP_001428077.1 602746 R 458234 CDS YP_001428078.1 156502013 5522699 complement(604052..604375) 1 NC_009749.1 thioredoxin 604375 trx1 5522699 trx1 Francisella tularensis subsp. holarctica FTNF002-00 thioredoxin YP_001428078.1 604052 R 458234 CDS YP_001428079.1 156502014 5522628 complement(605428..606141) 1 NC_009749.1 transposase ISFTu2 606141 5522628 FTA_0647 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428079.1 605428 R 458234 CDS YP_001428080.1 156502015 5522629 606936..607838 1 NC_009749.1 COG2256:MGS1,ATPase related to the helicase subunit of the Holliday junction resolvase; recombination factor protein RarA 607838 5522629 FTA_0648 Francisella tularensis subsp. holarctica FTNF002-00 recombination factor protein RarA YP_001428080.1 606936 D 458234 CDS YP_001428081.1 156502016 5522630 607926..608879 1 NC_009749.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 608879 rpoA2 5522630 rpoA2 Francisella tularensis subsp. holarctica FTNF002-00 DNA-directed RNA polymerase subunit alpha YP_001428081.1 607926 D 458234 CDS YP_001428082.2 169656553 5524404 complement(609498..609983) 1 NC_009749.1 ferritin-like protein 609983 5524404 FTA_0650 Francisella tularensis subsp. holarctica FTNF002-00 ferritin-like protein YP_001428082.2 609498 R 458234 CDS YP_001428085.1 156502020 5522634 611650..612417 1 NC_009749.1 TatD family hydrolase 612417 5522634 FTA_0653 Francisella tularensis subsp. holarctica FTNF002-00 TatD family hydrolase YP_001428085.1 611650 D 458234 CDS YP_001428087.1 156502022 5522636 complement(613652..614311) 1 NC_009749.1 transposase ISFTu2 614311 5522636 FTA_0655 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428087.1 613652 R 458234 CDS YP_001428088.1 156502023 5522637 614602..615525 1 NC_009749.1 ABC transporter ATP-binding protein 615525 5522637 FTA_0656 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter ATP-binding protein YP_001428088.1 614602 D 458234 CDS YP_001428089.2 169656554 5522638 615534..616313 1 NC_009749.1 ABC transporter membrane protein 616313 5522638 FTA_0657 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter membrane protein YP_001428089.2 615534 D 458234 CDS YP_001428090.1 156502025 5522639 complement(616317..617261) 1 NC_009749.1 glycosyl transferase family protein 617261 5522639 FTA_0658 Francisella tularensis subsp. holarctica FTNF002-00 glycosyl transferase family protein YP_001428090.1 616317 R 458234 CDS YP_001428091.1 156502026 5522640 617452..618342 1 NC_009749.1 NAD(+)/NADH kinase 618342 5522640 FTA_0659 Francisella tularensis subsp. holarctica FTNF002-00 NAD(+)/NADH kinase YP_001428091.1 617452 D 458234 CDS YP_001428092.2 169656555 5523688 complement(618349..618975) 1 NC_009749.1 amino acid transporter 618975 5523688 FTA_0660 Francisella tularensis subsp. holarctica FTNF002-00 amino acid transporter YP_001428092.2 618349 R 458234 CDS YP_001428093.1 156502028 5524262 619045..619734 1 NC_009749.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 619734 trmB 5524262 trmB Francisella tularensis subsp. holarctica FTNF002-00 tRNA (guanine-N(7)-)-methyltransferase YP_001428093.1 619045 D 458234 CDS YP_001428094.1 156502029 5524263 619744..620460 1 NC_009749.1 hypothetical protein 620460 5524263 FTA_0662 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428094.1 619744 D 458234 CDS YP_001428096.2 169656556 5524265 complement(join(621043..621594,621594..621923)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 621923 5524265 FTA_0664 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001428096.2 621043 R 458234 CDS YP_001428098.2 169656557 5524267 622073..622396 1 NC_009749.1 ArsR family transcriptional regulator 622396 5524267 FTA_0666 Francisella tularensis subsp. holarctica FTNF002-00 ArsR family transcriptional regulator YP_001428098.2 622073 D 458234 CDS YP_001428103.1 156502038 5524272 624742..625428 1 NC_009749.1 metallo-beta-lactamase family protein 625428 5524272 FTA_0671 Francisella tularensis subsp. holarctica FTNF002-00 metallo-beta-lactamase family protein YP_001428103.1 624742 D 458234 CDS YP_001428104.1 156502040 5524273 625430..626179 1 NC_009749.1 hypothetical protein 626179 5524273 FTA_0673 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428104.1 625430 D 458234 CDS YP_001428105.1 156502039 5524275 complement(626172..626780) 1 NC_009749.1 oxidoreductase, 2-oxoglutarate (2OG) and Fe(II)-dependent 626780 5524275 FTA_0672 Francisella tularensis subsp. holarctica FTNF002-00 oxidoreductase, 2-oxoglutarate (2OG) and Fe(II)-dependent YP_001428105.1 626172 R 458234 CDS YP_001428106.1 156502041 5524274 complement(626832..627281) 1 NC_009749.1 hypothetical protein 627281 5524274 FTA_0674 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428106.1 626832 R 458234 CDS YP_001428107.1 156502042 5522713 complement(627512..628012) 1 NC_009749.1 hypothetical protein 628012 5522713 FTA_0675 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428107.1 627512 R 458234 CDS YP_001428108.2 169656558 5522714 complement(628029..628526) 1 NC_009749.1 hypothetical protein 628526 5522714 FTA_0676 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428108.2 628029 R 458234 CDS YP_001428109.1 156502045 5522715 628606..629031 1 NC_009749.1 transcription antitermination factor 629031 nusB 5522715 nusB Francisella tularensis subsp. holarctica FTNF002-00 transcription antitermination factor YP_001428109.1 628606 D 458234 CDS YP_001428110.2 169656559 5522717 complement(629015..629800) 1 NC_009749.1 carbon-nitrogen family hydrolase 629800 5522717 FTA_0677 Francisella tularensis subsp. holarctica FTNF002-00 carbon-nitrogen family hydrolase YP_001428110.2 629015 R 458234 CDS YP_001428111.1 156502046 5522716 629954..630367 1 NC_009749.1 lipoprotein 630367 5522716 FTA_0679 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001428111.1 629954 D 458234 CDS YP_001428112.1 156502047 5522718 complement(630513..631322) 1 NC_009749.1 C-terminal truncation compred to Schu4 and WY96-3418; hypothetical protein 631322 5522718 FTA_0680 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428112.1 630513 R 458234 CDS YP_001428113.1 156502048 5522719 complement(631430..631912) 1 NC_009749.1 hypothetical protein 631912 5522719 FTA_0681 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428113.1 631430 R 458234 CDS YP_001428116.1 156502051 5522722 complement(633190..634887) 1 NC_009749.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 634887 proS 5522722 proS Francisella tularensis subsp. holarctica FTNF002-00 prolyl-tRNA synthetase YP_001428116.1 633190 R 458234 CDS YP_001428117.1 156502052 5522723 complement(635493..635690) 1 NC_009749.1 hypothetical protein 635690 5522723 FTA_0685 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428117.1 635493 R 458234 CDS YP_001428118.2 169656560 5522724 complement(635741..636250) 1 NC_009749.1 hypothetical protein 636250 5522724 FTA_0686 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428118.2 635741 R 458234 CDS YP_001428119.1 156502054 5522725 636987..637121 1 NC_009749.1 hypothetical protein 637121 5522725 FTA_0687 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428119.1 636987 D 458234 CDS YP_001428120.1 156502055 5522726 complement(637456..637992) 1 NC_009749.1 hypothetical protein 637992 5522726 FTA_0688 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428120.1 637456 R 458234 CDS YP_001715624.1 169656792 5983829 638070..638189 1 NC_009749.1 hypothetical protein 638189 5983829 FTA_2147 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001715624.1 638070 D 458234 CDS YP_001428121.1 156502056 5524658 638699..639115 1 NC_009749.1 Fe-S cluster assembly related protein 639115 sufE 5524658 sufE Francisella tularensis subsp. holarctica FTNF002-00 Fe-S cluster assembly related protein YP_001428121.1 638699 D 458234 CDS YP_001428122.1 156502057 5523647 639116..639865 1 NC_009749.1 putative uroporphyrinogen III synthase 639865 5523647 FTA_0690 Francisella tularensis subsp. holarctica FTNF002-00 putative uroporphyrinogen III synthase YP_001428122.1 639116 D 458234 CDS YP_001428123.1 156502058 5523648 639831..640916 1 NC_009749.1 hypothetical protein 640916 5523648 FTA_0691 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428123.1 639831 D 458234 CDS YP_001428124.1 156502059 5523649 640913..642070 1 NC_009749.1 hypothetical protein 642070 5523649 FTA_0692 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428124.1 640913 D 458234 CDS YP_001428125.1 156502060 5523650 642084..642842 1 NC_009749.1 hydroxyacylglutathione hydrolase 642842 5523650 FTA_0693 Francisella tularensis subsp. holarctica FTNF002-00 hydroxyacylglutathione hydrolase YP_001428125.1 642084 D 458234 CDS YP_001428126.1 156502061 5523651 complement(642920..643627) 1 NC_009749.1 putative cell division protein 643627 5523651 FTA_0694 Francisella tularensis subsp. holarctica FTNF002-00 putative cell division protein YP_001428126.1 642920 R 458234 CDS YP_001428127.1 156502062 5523652 643820..643960 1 NC_009749.1 hypothetical protein 643960 5523652 FTA_0695 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428127.1 643820 D 458234 CDS YP_001428128.1 156502063 5523653 643977..645611 1 NC_009749.1 hypothetical protein 645611 5523653 FTA_0696 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428128.1 643977 D 458234 CDS YP_001428129.1 156502064 5524405 complement(646183..646836) 1 NC_009749.1 peptidase S24-like domain-containing protein 646836 5524405 FTA_0697 Francisella tularensis subsp. holarctica FTNF002-00 peptidase S24-like domain-containing protein YP_001428129.1 646183 R 458234 CDS YP_001428130.1 156502065 5523655 647005..647373 1 NC_009749.1 hypothetical protein 647373 5523655 FTA_0698 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428130.1 647005 D 458234 CDS YP_001428131.1 156502066 5523656 complement(647404..648276) 1 NC_009749.1 integral membrane protein 648276 5523656 FTA_0699 Francisella tularensis subsp. holarctica FTNF002-00 integral membrane protein YP_001428131.1 647404 R 458234 CDS YP_001428132.1 156502067 5523657 648453..650039 1 NC_009749.1 putative glutamate synthase 650039 5523657 FTA_0700 Francisella tularensis subsp. holarctica FTNF002-00 putative glutamate synthase YP_001428132.1 648453 D 458234 CDS YP_001428133.1 156502068 5523658 650116..653355 1 NC_009749.1 exodeoxyribonuclease V subunit gamma 653355 recC 5523658 recC Francisella tularensis subsp. holarctica FTNF002-00 exodeoxyribonuclease V subunit gamma YP_001428133.1 650116 D 458234 CDS YP_001428134.1 156502069 5523659 653339..653869 1 NC_009749.1 hypothetical protein 653869 5523659 FTA_0702 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428134.1 653339 D 458234 CDS YP_001428135.1 156502070 5524225 654012..655442 1 NC_009749.1 ATP-binding transcriptional regulator 655442 5524225 FTA_0703 Francisella tularensis subsp. holarctica FTNF002-00 ATP-binding transcriptional regulator YP_001428135.1 654012 D 458234 CDS YP_001428136.1 156502071 5524226 655514..659167 1 NC_009749.1 exodeoxyribonuclease V subunit beta 659167 recB 5524226 recB Francisella tularensis subsp. holarctica FTNF002-00 exodeoxyribonuclease V subunit beta YP_001428136.1 655514 D 458234 CDS YP_001428137.1 156502072 5524227 659160..661001 1 NC_009749.1 exodeoxyribonuclease V subunit alpha 661001 recD 5524227 recD Francisella tularensis subsp. holarctica FTNF002-00 exodeoxyribonuclease V subunit alpha YP_001428137.1 659160 D 458234 CDS YP_001428138.1 156502073 5524228 complement(661010..661780) 1 NC_009749.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 661780 5524228 FTA_0706 Francisella tularensis subsp. holarctica FTNF002-00 pantothenate kinase YP_001428138.1 661010 R 458234 CDS YP_001428139.1 156502074 5524229 complement(661784..662119) 1 NC_009749.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 662119 panD 5524229 panD Francisella tularensis subsp. holarctica FTNF002-00 aspartate alpha-decarboxylase YP_001428139.1 661784 R 458234 CDS YP_001428140.1 156502075 5524230 complement(662113..662898) 1 NC_009749.1 pantoate--beta-alanine ligase 662898 panC 5524230 panC Francisella tularensis subsp. holarctica FTNF002-00 pantoate--beta-alanine ligase YP_001428140.1 662113 R 458234 CDS YP_001428141.1 156502076 5524231 complement(662885..663682) 1 NC_009749.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 663682 panB 5524231 panB Francisella tularensis subsp. holarctica FTNF002-00 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_001428141.1 662885 R 458234 CDS YP_001428142.1 156502077 5524232 complement(663684..664343) 1 NC_009749.1 hypothetical protein 664343 5524232 FTA_0710 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428142.1 663684 R 458234 CDS YP_001428143.1 156502078 5524233 664705..666741 1 NC_009749.1 DNA ligase 666741 ligA 5524233 ligA Francisella tularensis subsp. holarctica FTNF002-00 DNA ligase YP_001428143.1 664705 D 458234 CDS YP_001428144.1 156502080 5524234 666738..667115 1 NC_009749.1 hypothetical protein 667115 5524234 FTA_0713 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428144.1 666738 D 458234 CDS YP_001428145.2 169656561 5524236 complement(join(667093..667644,667644..667973)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 667973 5524236 FTA_0712 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001428145.2 667093 R 458234 CDS YP_001428147.1 156502082 5524237 complement(668197..669003) 1 NC_009749.1 ABC transporter permease 669003 5524237 FTA_0715 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter permease YP_001428147.1 668197 R 458234 CDS YP_001428148.1 156502083 5524238 complement(669017..669898) 1 NC_009749.1 polyamine ABC transporter permease 669898 5524238 FTA_0716 Francisella tularensis subsp. holarctica FTNF002-00 polyamine ABC transporter permease YP_001428148.1 669017 R 458234 CDS YP_001428149.1 156502084 5523588 complement(669898..671019) 1 NC_009749.1 polyamine ABC transporter ATP-binding protein 671019 5523588 FTA_0717 Francisella tularensis subsp. holarctica FTNF002-00 polyamine ABC transporter ATP-binding protein YP_001428149.1 669898 R 458234 CDS YP_001428150.1 156502085 5523589 671164..671301 1 NC_009749.1 hypothetical protein 671301 5523589 FTA_0718 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428150.1 671164 D 458234 CDS YP_001428151.2 169656562 5523590 complement(join(671302..671853,671853..672182)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 672182 5523590 FTA_0719 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001428151.2 671302 R 458234 CDS YP_001428153.1 156502088 5523592 672277..672420 1 NC_009749.1 quinone-oxidoreductase QR2 672420 5523592 FTA_0721 Francisella tularensis subsp. holarctica FTNF002-00 quinone-oxidoreductase QR2 YP_001428153.1 672277 D 458234 CDS YP_001428155.1 156502090 5523594 complement(672952..673374) 1 NC_009749.1 hypothetical protein 673374 5523594 FTA_0723 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428155.1 672952 R 458234 CDS YP_001428156.1 156502091 5523595 complement(673478..674227) 1 NC_009749.1 NAD+ synthetase 674227 nadE 5523595 nadE Francisella tularensis subsp. holarctica FTNF002-00 NAD+ synthetase YP_001428156.1 673478 R 458234 CDS YP_001428157.1 156502092 5523596 complement(674356..675828) 1 NC_009749.1 outer membrane efflux protein 675828 5523596 FTA_0725 Francisella tularensis subsp. holarctica FTNF002-00 outer membrane efflux protein YP_001428157.1 674356 R 458234 CDS YP_001428158.1 156502093 5523597 complement(675838..676860) 1 NC_009749.1 HlyD family secretion protein 676860 5523597 FTA_0726 Francisella tularensis subsp. holarctica FTNF002-00 HlyD family secretion protein YP_001428158.1 675838 R 458234 CDS YP_001428159.1 156502094 5523598 complement(676882..678411) 1 NC_009749.1 drug:H+ antiporter-1 (DHA2) family protein 678411 5523598 FTA_0727 Francisella tularensis subsp. holarctica FTNF002-00 drug:H+ antiporter-1 (DHA2) family protein YP_001428159.1 676882 R 458234 CDS YP_001428160.1 156502096 5523599 678576..679403 1 NC_009749.1 AraC family transcriptional regulator 679403 5523599 FTA_0729 Francisella tularensis subsp. holarctica FTNF002-00 AraC family transcriptional regulator YP_001428160.1 678576 D 458234 CDS YP_001428161.1 156502095 5523601 complement(679391..681082) 1 NC_009749.1 PRK08974, PRK08974:long-chain-fatty-acid--CoA ligase.(e-value:2e-128); long-chain-fatty-acid--CoA ligase 681082 5523601 FTA_0728 Francisella tularensis subsp. holarctica FTNF002-00 long-chain-fatty-acid--CoA ligase YP_001428161.1 679391 R 458234 CDS YP_001428162.1 156502097 5523600 complement(681190..682677) 1 NC_009749.1 amino acid/peptide transporter 682677 5523600 FTA_0730 Francisella tularensis subsp. holarctica FTNF002-00 amino acid/peptide transporter YP_001428162.1 681190 R 458234 CDS YP_001428163.2 169656563 5524015 complement(682907..683635) 1 NC_009749.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 683635 5524015 FTA_0731 Francisella tularensis subsp. holarctica FTNF002-00 16S ribosomal RNA methyltransferase RsmE YP_001428163.2 682907 R 458234 CDS YP_001428164.1 156502100 5524016 683706..684392 1 NC_009749.1 hypothetical protein 684392 5524016 FTA_0733 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428164.1 683706 D 458234 CDS YP_001428165.1 156502099 5524018 complement(684382..685080) 1 NC_009749.1 hypothetical protein 685080 5524018 FTA_0732 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428165.1 684382 R 458234 CDS YP_001428166.2 169656564 5524017 complement(685085..685810) 1 NC_009749.1 hypothetical protein 685810 5524017 FTA_0734 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428166.2 685085 R 458234 CDS YP_001428167.1 156502102 5524019 complement(685820..686581) 1 NC_009749.1 ABC transporter ATP-binding protein 686581 5524019 FTA_0735 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter ATP-binding protein YP_001428167.1 685820 R 458234 CDS YP_001428168.1 156502103 5524020 complement(686596..687696) 1 NC_009749.1 ABC transporter membrane protein 687696 5524020 FTA_0736 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter membrane protein YP_001428168.1 686596 R 458234 CDS YP_001428169.1 156502104 5524021 complement(687771..688568) 1 NC_009749.1 hypothetical protein 688568 5524021 FTA_0737 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428169.1 687771 R 458234 CDS YP_001428170.2 169656565 5524022 complement(688561..689559) 1 NC_009749.1 RNA pseudouridine synthase, RluA family protein 689559 5524022 FTA_0738 Francisella tularensis subsp. holarctica FTNF002-00 RNA pseudouridine synthase, RluA family protein YP_001428170.2 688561 R 458234 CDS YP_001428171.2 169656566 5524023 689647..690471 1 NC_009749.1 lipoprotein 690471 5524023 FTA_0739 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001428171.2 689647 D 458234 CDS YP_001428174.1 156502109 5524026 complement(692418..693875) 1 NC_009749.1 hypothetical protein 693875 5524026 FTA_0742 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428174.1 692418 R 458234 CDS YP_001428175.1 156502110 5524027 complement(694153..695406) 1 NC_009749.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 695406 glyA 5524027 glyA Francisella tularensis subsp. holarctica FTNF002-00 serine hydroxymethyltransferase YP_001428175.1 694153 R 458234 CDS YP_001428176.1 156502111 5524028 695510..696058 1 NC_009749.1 hypothetical protein 696058 5524028 FTA_0744 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428176.1 695510 D 458234 CDS YP_001428177.1 156502112 5523345 complement(696073..697344) 1 NC_009749.1 hypothetical protein 697344 5523345 FTA_0745 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428177.1 696073 R 458234 CDS YP_001428178.1 156502113 5523346 697552..698883 1 NC_009749.1 hypothetical protein 698883 5523346 FTA_0746 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428178.1 697552 D 458234 CDS YP_001428179.1 156502114 5523347 complement(698909..699799) 1 NC_009749.1 glycosyl transferase family protein 699799 5523347 FTA_0747 Francisella tularensis subsp. holarctica FTNF002-00 glycosyl transferase family protein YP_001428179.1 698909 R 458234 CDS YP_001428180.1 156502115 5523348 complement(699807..700895) 1 NC_009749.1 hypothetical protein 700895 5523348 FTA_0748 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428180.1 699807 R 458234 CDS YP_001428181.1 156502116 5523349 701065..702129 1 NC_009749.1 group 1 family glycosyltransferase 702129 5523349 FTA_0749 Francisella tularensis subsp. holarctica FTNF002-00 group 1 family glycosyltransferase YP_001428181.1 701065 D 458234 CDS YP_001428182.1 156502117 5523350 complement(702206..703159) 1 NC_009749.1 linear amide C-N hydrolase 703159 5523350 FTA_0750 Francisella tularensis subsp. holarctica FTNF002-00 linear amide C-N hydrolase YP_001428182.1 702206 R 458234 CDS YP_001428185.1 156502120 5523353 complement(704856..706052) 1 NC_009749.1 tRNA(Ile)-lysidine synthase 706052 5523353 FTA_0753 Francisella tularensis subsp. holarctica FTNF002-00 tRNA(Ile)-lysidine synthase YP_001428185.1 704856 R 458234 CDS YP_001428186.1 156502121 5523354 complement(706053..707288) 1 NC_009749.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 707288 5523354 FTA_0754 Francisella tularensis subsp. holarctica FTNF002-00 D-3-phosphoglycerate dehydrogenase YP_001428186.1 706053 R 458234 CDS YP_001428187.1 156502122 5523355 complement(707300..708124) 1 NC_009749.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 708124 thyA 5523355 thyA Francisella tularensis subsp. holarctica FTNF002-00 thymidylate synthase YP_001428187.1 707300 R 458234 CDS YP_001428188.1 156502123 5523356 complement(708109..708915) 1 NC_009749.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 708915 lgt 5523356 lgt Francisella tularensis subsp. holarctica FTNF002-00 prolipoprotein diacylglyceryl transferase YP_001428188.1 708109 R 458234 CDS YP_001428189.1 156502124 5523357 complement(708930..711461) 1 NC_009749.1 deletion comapred to Schu4 and WY96-3418 ORFs; ribonuclease 711461 5523357 FTA_0757 Francisella tularensis subsp. holarctica FTNF002-00 ribonuclease YP_001428189.1 708930 R 458234 CDS YP_001428190.1 156502125 5523358 711711..712886 1 NC_009749.1 cysteine desulfarase 712886 5523358 FTA_0758 Francisella tularensis subsp. holarctica FTNF002-00 cysteine desulfarase YP_001428190.1 711711 D 458234 CDS YP_001428191.1 156502126 5523375 712879..713208 1 NC_009749.1 hypothetical protein 713208 5523375 FTA_0759 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428191.1 712879 D 458234 CDS YP_001428192.2 169656567 5523376 713192..713890 1 NC_009749.1 putative DNA repair protein 713890 5523376 FTA_0760 Francisella tularensis subsp. holarctica FTNF002-00 putative DNA repair protein YP_001428192.2 713192 D 458234 CDS YP_001428193.1 156502128 5523377 complement(713966..714613) 1 NC_009749.1 hypothetical protein 714613 5523377 FTA_0761 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428193.1 713966 R 458234 CDS YP_001428194.1 156502129 5523378 complement(714669..715295) 1 NC_009749.1 hypothetical protein 715295 5523378 FTA_0762 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428194.1 714669 R 458234 CDS YP_001428195.1 156502130 5523379 complement(715302..715568) 1 NC_009749.1 hypothetical protein 715568 5523379 FTA_0763 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428195.1 715302 R 458234 CDS YP_001428196.1 156502131 5523380 complement(715571..716119) 1 NC_009749.1 5,10-methenyltetrahydrofolate synthetase 716119 5523380 FTA_0764 Francisella tularensis subsp. holarctica FTNF002-00 5,10-methenyltetrahydrofolate synthetase YP_001428196.1 715571 R 458234 CDS YP_001428197.1 156502132 5523381 716559..717095 1 NC_009749.1 hypothetical protein 717095 5523381 FTA_0765 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428197.1 716559 D 458234 CDS YP_001428198.1 156502133 5523382 717104..718315 1 NC_009749.1 2-octaprenyl-6-methoxyphenyl hydroxylase 718315 5523382 FTA_0766 Francisella tularensis subsp. holarctica FTNF002-00 2-octaprenyl-6-methoxyphenyl hydroxylase YP_001428198.1 717104 D 458234 CDS YP_001428199.1 156502134 5523383 718305..719540 1 NC_009749.1 ubiquinone biosynthesis hydroxylase/FAD-dependent monooxygenase 719540 5523383 FTA_0767 Francisella tularensis subsp. holarctica FTNF002-00 ubiquinone biosynthesis hydroxylase/FAD-dependent monooxygenase YP_001428199.1 718305 D 458234 CDS YP_001428200.1 156502135 5523384 719562..720023 1 NC_009749.1 hypothetical protein 720023 5523384 FTA_0768 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428200.1 719562 D 458234 CDS YP_001428201.1 156502136 5523385 720049..721065 1 NC_009749.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 721065 queA 5523385 queA Francisella tularensis subsp. holarctica FTNF002-00 S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_001428201.1 720049 D 458234 CDS YP_001428202.1 156502137 5523386 721700..722491 1 NC_009749.1 HAD family hydrolase 722491 5523386 FTA_0770 Francisella tularensis subsp. holarctica FTNF002-00 HAD family hydrolase YP_001428202.1 721700 D 458234 CDS YP_001428203.1 156502138 5523387 complement(722745..723458) 1 NC_009749.1 hypothetical protein 723458 5523387 FTA_0771 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428203.1 722745 R 458234 CDS YP_001428204.1 156502139 5523388 723574..723957 1 NC_009749.1 lactoylglutathione lyase 723957 gloA 5523388 gloA Francisella tularensis subsp. holarctica FTNF002-00 lactoylglutathione lyase YP_001428204.1 723574 D 458234 CDS YP_001428205.2 169656568 5523719 join(724411..724740,724740..725291) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 725291 5523719 FTA_0773 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001428205.2 724411 D 458234 CDS YP_001428209.1 156502144 5523723 complement(727221..727895) 1 NC_009749.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 727895 rpiA 5523723 rpiA Francisella tularensis subsp. holarctica FTNF002-00 ribose-5-phosphate isomerase A YP_001428209.1 727221 R 458234 CDS YP_001428210.1 156502145 5523724 complement(727897..729267) 1 NC_009749.1 hypothetical protein 729267 5523724 FTA_0778 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428210.1 727897 R 458234 CDS YP_001428211.1 156502146 5523725 complement(729281..729673) 1 NC_009749.1 hypothetical protein 729673 5523725 FTA_0779 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428211.1 729281 R 458234 CDS YP_001428212.1 156502147 5523726 complement(729685..731568) 1 NC_009749.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 731568 gidA 5523726 gidA Francisella tularensis subsp. holarctica FTNF002-00 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_001428212.1 729685 R 458234 CDS YP_001428213.1 156502148 5523727 731711..732793 1 NC_009749.1 hypothetical protein 732793 5523727 FTA_0781 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428213.1 731711 D 458234 CDS YP_001428214.1 156502149 5523728 732780..733685 1 NC_009749.1 hypothetical protein 733685 5523728 FTA_0782 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428214.1 732780 D 458234 CDS YP_001428217.1 156502152 5523731 734641..735363 1 NC_009749.1 short chain dehydrogenase/reductase family oxidoreductase 735363 5523731 FTA_0785 Francisella tularensis subsp. holarctica FTNF002-00 short chain dehydrogenase/reductase family oxidoreductase YP_001428217.1 734641 D 458234 CDS YP_001428218.1 156502153 5523732 735497..736945 1 NC_009749.1 exonuclease 736945 5523732 FTA_0786 Francisella tularensis subsp. holarctica FTNF002-00 exonuclease YP_001428218.1 735497 D 458234 CDS YP_001428219.1 156502154 5523959 736947..738953 1 NC_009749.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 738953 uvrB 5523959 uvrB Francisella tularensis subsp. holarctica FTNF002-00 excinuclease ABC subunit B YP_001428219.1 736947 D 458234 CDS YP_001428220.1 156502155 5523960 738957..739787 1 NC_009749.1 hypothetical protein 739787 5523960 FTA_0788 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428220.1 738957 D 458234 CDS YP_001428221.1 156502156 5523961 739787..740584 1 NC_009749.1 glutamate racemase 740584 murI 5523961 murI Francisella tularensis subsp. holarctica FTNF002-00 glutamate racemase YP_001428221.1 739787 D 458234 CDS YP_001428222.1 156502157 5523962 740675..741952 1 NC_009749.1 major facilitator transporter 741952 5523962 FTA_0790 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001428222.1 740675 D 458234 CDS YP_001428223.1 156502158 5523963 742206..742856 1 NC_009749.1 transposase ISFTu2 742856 5523963 FTA_0791 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428223.1 742206 D 458234 CDS YP_001428224.1 156502159 5523964 742970..744337 1 NC_009749.1 hypothetical protein 744337 5523964 FTA_0792 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428224.1 742970 D 458234 CDS YP_001428225.1 156502160 5523965 744484..745410 1 NC_009749.1 hypothetical protein 745410 5523965 FTA_0793 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428225.1 744484 D 458234 CDS YP_001428226.1 156502161 5523966 745427..747178 1 NC_009749.1 transglutaminase-like superfamily protein 747178 5523966 FTA_0794 Francisella tularensis subsp. holarctica FTNF002-00 transglutaminase-like superfamily protein YP_001428226.1 745427 D 458234 CDS YP_001428229.1 156502164 5523969 748541..749926 1 NC_009749.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 749926 xseA 5523969 xseA Francisella tularensis subsp. holarctica FTNF002-00 exodeoxyribonuclease VII large subunit YP_001428229.1 748541 D 458234 CDS YP_001428230.1 156502165 5523970 749910..750110 1 NC_009749.1 hypothetical protein 750110 5523970 FTA_0798 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428230.1 749910 D 458234 CDS YP_001428234.1 156502169 5524060 complement(751723..752334) 1 NC_009749.1 hypothetical protein 752334 5524060 FTA_0802 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428234.1 751723 R 458234 CDS YP_001428235.1 156502170 5524061 complement(752601..753356) 1 NC_009749.1 ATPase 753356 5524061 FTA_0803 Francisella tularensis subsp. holarctica FTNF002-00 ATPase YP_001428235.1 752601 R 458234 CDS YP_001428236.1 156502171 5524062 complement(753357..753830) 1 NC_009749.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 753830 smpB 5524062 smpB Francisella tularensis subsp. holarctica FTNF002-00 SsrA-binding protein YP_001428236.1 753357 R 458234 CDS YP_001428237.1 156502172 5524063 753905..754336 1 NC_009749.1 hypothetical protein 754336 5524063 FTA_0805 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428237.1 753905 D 458234 CDS YP_001428238.1 156502173 5524064 754336..754641 1 NC_009749.1 hypothetical protein 754641 5524064 FTA_0806 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428238.1 754336 D 458234 CDS YP_001428239.1 156502174 5524065 754683..755888 1 NC_009749.1 FAD dependent oxidoreductase 755888 5524065 FTA_0807 Francisella tularensis subsp. holarctica FTNF002-00 FAD dependent oxidoreductase YP_001428239.1 754683 D 458234 CDS YP_001428240.2 169656569 5524066 755965..756885 1 NC_009749.1 putative VacJ-like lipoprotein 756885 5524066 FTA_0808 Francisella tularensis subsp. holarctica FTNF002-00 putative VacJ-like lipoprotein YP_001428240.2 755965 D 458234 CDS YP_001428241.2 169656570 5524067 756940..758745 1 NC_009749.1 gamma-glutamyltransferase 758745 ggt 5524067 ggt Francisella tularensis subsp. holarctica FTNF002-00 gamma-glutamyltransferase YP_001428241.2 756940 D 458234 CDS YP_001428242.1 156502177 5524068 complement(758761..759516) 1 NC_009749.1 hypothetical protein 759516 5524068 FTA_0810 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428242.1 758761 R 458234 CDS YP_001428243.1 156502178 5524069 complement(759688..761505) 1 NC_009749.1 GTP binding translational elongation factor Tu and G family protein 761505 typA 5524069 typA Francisella tularensis subsp. holarctica FTNF002-00 GTP binding translational elongation factor Tu and G family protein YP_001428243.1 759688 R 458234 CDS YP_001428244.1 156502179 5524070 761995..763479 1 NC_009749.1 hypothetical protein 763479 5524070 FTA_0812 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428244.1 761995 D 458234 CDS YP_001428251.1 156502186 5523452 765958..766728 1 NC_009749.1 hypothetical protein 766728 5523452 FTA_0819 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428251.1 765958 D 458234 CDS YP_001428252.1 156502187 5523453 766819..767007 1 NC_009749.1 hypothetical protein 767007 5523453 FTA_0820 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428252.1 766819 D 458234 CDS YP_001428255.1 156502190 5523456 768519..768950 1 NC_009749.1 cold shock DNA-binding domain-containing protein 768950 5523456 FTA_0823 Francisella tularensis subsp. holarctica FTNF002-00 cold shock DNA-binding domain-containing protein YP_001428255.1 768519 D 458234 CDS YP_001428258.2 169656571 5523460 complement(join(770239..770790,770790..771119)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFTu1 771119 5523460 FTA_0825 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu1 YP_001428258.2 770239 R 458234 CDS YP_001428261.1 156502195 5524552 complement(771348..773096) 1 NC_009749.1 hypothetical protein 773096 5524552 FTA_0828 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428261.1 771348 R 458234 CDS YP_001428262.2 169656572 5524551 complement(773163..774035) 1 NC_009749.1 GTP-binding protein 774035 5524551 FTA_0830 Francisella tularensis subsp. holarctica FTNF002-00 GTP-binding protein YP_001428262.2 773163 R 458234 CDS YP_001428263.1 156502198 5524553 774098..775231 1 NC_009749.1 N-acetylglucosamine-6-phosphate deacetylase 775231 nagA 5524553 nagA Francisella tularensis subsp. holarctica FTNF002-00 N-acetylglucosamine-6-phosphate deacetylase YP_001428263.1 774098 D 458234 CDS YP_001428264.2 169656573 5524554 775235..775873 1 NC_009749.1 glycoprotease family protein 775873 5524554 FTA_0832 Francisella tularensis subsp. holarctica FTNF002-00 glycoprotease family protein YP_001428264.2 775235 D 458234 CDS YP_001428265.2 169656574 5524555 775877..776683 1 NC_009749.1 glutamine amidotransferases class-II family protein 776683 5524555 FTA_0833 Francisella tularensis subsp. holarctica FTNF002-00 glutamine amidotransferases class-II family protein YP_001428265.2 775877 D 458234 CDS YP_001428266.1 156502201 5524556 776693..777886 1 NC_009749.1 aspartate aminotransferase 777886 5524556 FTA_0834 Francisella tularensis subsp. holarctica FTNF002-00 aspartate aminotransferase YP_001428266.1 776693 D 458234 CDS YP_001428267.1 156502202 5524557 778000..778893 1 NC_009749.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 778893 era 5524557 era Francisella tularensis subsp. holarctica FTNF002-00 GTP-binding protein Era YP_001428267.1 778000 D 458234 CDS YP_001428268.1 156502203 5524558 779060..779323 1 NC_009749.1 N-terminal truncation compared to Schu4 and WY96-3418 ORFs; hypothetical protein 779323 5524558 FTA_0836 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428268.1 779060 D 458234 CDS YP_001428272.1 156502207 5524562 complement(782663..783319) 1 NC_009749.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 783319 adk 5524562 adk Francisella tularensis subsp. holarctica FTNF002-00 adenylate kinase YP_001428272.1 782663 R 458234 CDS YP_001428273.1 156502208 5524563 783446..784450 1 NC_009749.1 hypothetical protein 784450 5524563 FTA_0841 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428273.1 783446 D 458234 CDS YP_001428274.1 156502209 5524564 784452..785015 1 NC_009749.1 Type IV pili associated protein 785015 5524564 FTA_0842 Francisella tularensis subsp. holarctica FTNF002-00 Type IV pili associated protein YP_001428274.1 784452 D 458234 CDS YP_001428275.2 169656575 5523932 785009..785605 1 NC_009749.1 type IV pili associated protein 785605 5523932 FTA_0843 Francisella tularensis subsp. holarctica FTNF002-00 type IV pili associated protein YP_001428275.2 785009 D 458234 CDS YP_001428276.1 156502211 5523933 785611..786201 1 NC_009749.1 pilus assembly protein 786201 5523933 FTA_0844 Francisella tularensis subsp. holarctica FTNF002-00 pilus assembly protein YP_001428276.1 785611 D 458234 CDS YP_001428277.1 156502212 5523934 786214..787986 1 NC_009749.1 type IV pilus secretin 787986 5523934 FTA_0845 Francisella tularensis subsp. holarctica FTNF002-00 type IV pilus secretin YP_001428277.1 786214 D 458234 CDS YP_001428278.1 156502213 5523935 788112..788642 1 NC_009749.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 788642 aroK 5523935 aroK Francisella tularensis subsp. holarctica FTNF002-00 shikimate kinase I YP_001428278.1 788112 D 458234 CDS YP_001428279.1 156502214 5523936 788639..789718 1 NC_009749.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 789718 aroB 5523936 aroB Francisella tularensis subsp. holarctica FTNF002-00 3-dehydroquinate synthase YP_001428279.1 788639 D 458234 CDS YP_001428280.1 156502215 5523937 789776..789901 1 NC_009749.1 hypothetical protein 789901 5523937 FTA_0848 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428280.1 789776 D 458234 CDS YP_001428281.1 156502216 5523938 complement(790067..790450) 1 NC_009749.1 hypothetical protein 790450 5523938 FTA_0849 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428281.1 790067 R 458234 CDS YP_001428282.1 156502217 5523939 790664..790951 1 NC_009749.1 hypothetical protein 790951 5523939 FTA_0850 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428282.1 790664 D 458234 CDS YP_001428283.1 156502218 5523940 790968..795032 1 NC_009749.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 795032 putA 5523940 putA Francisella tularensis subsp. holarctica FTNF002-00 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_001428283.1 790968 D 458234 CDS YP_001428284.2 169656576 5523941 795192..796700 1 NC_009749.1 amino acid transporter 796700 5523941 FTA_0852 Francisella tularensis subsp. holarctica FTNF002-00 amino acid transporter YP_001428284.2 795192 D 458234 CDS YP_001428285.1 156502220 5523942 796776..797960 1 NC_009749.1 major facilitator transporter 797960 5523942 FTA_0853 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001428285.1 796776 D 458234 CDS YP_001428286.1 156502221 5523943 797973..799148 1 NC_009749.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase 799148 coaBC 5523943 coaBC Francisella tularensis subsp. holarctica FTNF002-00 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase YP_001428286.1 797973 D 458234 CDS YP_001428289.1 156502224 5523733 complement(800232..800462) 1 NC_009749.1 cation transport regulator 800462 5523733 FTA_0857 Francisella tularensis subsp. holarctica FTNF002-00 cation transport regulator YP_001428289.1 800232 R 458234 CDS YP_001428293.1 156502228 5523737 complement(801521..801724) 1 NC_009749.1 N-terminal truncated comapred to Schu4 and WY96-3418 ORFs; hypothetical protein 801724 5523737 FTA_0861 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428293.1 801521 R 458234 CDS YP_001428294.1 156502229 5523738 complement(801836..802261) 1 NC_009749.1 PRC-barrel domain-containing protein 802261 5523738 FTA_0862 Francisella tularensis subsp. holarctica FTNF002-00 PRC-barrel domain-containing protein YP_001428294.1 801836 R 458234 CDS YP_001428295.1 156502230 5523739 complement(802460..802675) 1 NC_009749.1 PRC-barrel domain-containing protein 802675 5523739 FTA_0863 Francisella tularensis subsp. holarctica FTNF002-00 PRC-barrel domain-containing protein YP_001428295.1 802460 R 458234 CDS YP_001428296.1 156502231 5523740 complement(802730..802927) 1 NC_009749.1 hypothetical protein 802927 5523740 FTA_0864 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428296.1 802730 R 458234 CDS YP_001428297.1 156502232 5523741 803546..803668 1 NC_009749.1 hypothetical protein 803668 5523741 FTA_0865 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428297.1 803546 D 458234 CDS YP_001715625.1 169656793 5983831 complement(805865..806014) 1 NC_009749.1 hypothetical protein 806014 5983831 FTA_2149 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001715625.1 805865 R 458234 CDS YP_001428302.1 156502237 5523746 complement(805999..806997) 1 NC_009749.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 806997 hemH 5523746 hemH Francisella tularensis subsp. holarctica FTNF002-00 ferrochelatase YP_001428302.1 805999 R 458234 CDS YP_001428303.1 156502238 5523420 807131..807391 1 NC_009749.1 hypothetical protein 807391 5523420 FTA_0871 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428303.1 807131 D 458234 CDS YP_001428304.1 156502239 5523421 807351..807743 1 NC_009749.1 hypothetical protein 807743 5523421 FTA_0872 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428304.1 807351 D 458234 CDS YP_001428308.1 156502243 5523425 complement(808989..810218) 1 NC_009749.1 Type IV pili polytopic inner membrane protein 810218 5523425 FTA_0876 Francisella tularensis subsp. holarctica FTNF002-00 Type IV pili polytopic inner membrane protein YP_001428308.1 808989 R 458234 CDS YP_001428309.1 156502244 5523426 complement(810233..812014) 1 NC_009749.1 type II secretion system protein/type IV-A pilus assembly ATPase PilB 812014 pilB 5523426 pilB Francisella tularensis subsp. holarctica FTNF002-00 type II secretion system protein/type IV-A pilus assembly ATPase PilB YP_001428309.1 810233 R 458234 CDS YP_001428310.1 156502246 5523427 812172..812924 1 NC_009749.1 glycerophosphoryl diester phosphodiesterase 812924 5523427 FTA_0879 Francisella tularensis subsp. holarctica FTNF002-00 glycerophosphoryl diester phosphodiesterase YP_001428310.1 812172 D 458234 CDS YP_001428311.1 156502245 5523429 complement(812913..813656) 1 NC_009749.1 molybdopterin binding domain-containing protein 813656 5523429 FTA_0878 Francisella tularensis subsp. holarctica FTNF002-00 molybdopterin binding domain-containing protein YP_001428311.1 812913 R 458234 CDS YP_001428312.1 156502247 5523428 813780..816602 1 NC_009749.1 catalyze the formation of cyanophycin which may act to store excess nitrogen; cyanophycin synthetase 816602 5523428 FTA_0880 Francisella tularensis subsp. holarctica FTNF002-00 cyanophycin synthetase YP_001428312.1 813780 D 458234 CDS YP_001428313.1 156502248 5523430 816628..818313 1 NC_009749.1 UDP-N-acetylmuramyl tripeptide synthase 818313 5523430 FTA_0881 Francisella tularensis subsp. holarctica FTNF002-00 UDP-N-acetylmuramyl tripeptide synthase YP_001428313.1 816628 D 458234 CDS YP_001428314.1 156502249 5523431 complement(818318..818797) 1 NC_009749.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 818797 ispF 5523431 ispF Francisella tularensis subsp. holarctica FTNF002-00 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_001428314.1 818318 R 458234 CDS YP_001428315.1 156502250 5523432 complement(818810..819568) 1 NC_009749.1 rhodanese-like domain-containing protein 819568 5523432 FTA_0883 Francisella tularensis subsp. holarctica FTNF002-00 rhodanese-like domain-containing protein YP_001428315.1 818810 R 458234 CDS YP_001428319.1 156502254 5523790 complement(820825..822297) 1 NC_009749.1 ABC transporter permease 822297 5523790 FTA_0887 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter permease YP_001428319.1 820825 R 458234 CDS YP_001428320.1 156502255 5523791 complement(822275..823327) 1 NC_009749.1 ABC transporter ATP-binding protein 823327 5523791 FTA_0888 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter ATP-binding protein YP_001428320.1 822275 R 458234 CDS YP_001428321.1 156502256 5523792 complement(823314..823928) 1 NC_009749.1 hypothetical protein 823928 5523792 FTA_0889 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428321.1 823314 R 458234 CDS YP_001428324.1 156502259 5523795 complement(825783..826004) 1 NC_009749.1 hypothetical protein 826004 5523795 FTA_0892 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428324.1 825783 R 458234 CDS YP_001428325.1 156502260 5523796 826310..827413 1 NC_009749.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 827413 tgt 5523796 tgt Francisella tularensis subsp. holarctica FTNF002-00 queuine tRNA-ribosyltransferase YP_001428325.1 826310 D 458234 CDS YP_001428328.2 169656577 5523799 828401..829216 1 NC_009749.1 integral membrane protein 829216 5523799 FTA_0896 Francisella tularensis subsp. holarctica FTNF002-00 integral membrane protein YP_001428328.2 828401 D 458234 CDS YP_001428329.1 156502264 5523800 829288..829860 1 NC_009749.1 isochorismatase hydrolase family protein 829860 5523800 FTA_0897 Francisella tularensis subsp. holarctica FTNF002-00 isochorismatase hydrolase family protein YP_001428329.1 829288 D 458234 CDS YP_001428330.1 156502265 5523801 829979..830152 1 NC_009749.1 hypothetical protein 830152 5523801 FTA_0898 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428330.1 829979 D 458234 CDS YP_001428331.2 169656578 5523273 830415..830771 1 NC_009749.1 preprotein translocase subunit YajC 830771 yajC 5523273 yajC Francisella tularensis subsp. holarctica FTNF002-00 preprotein translocase subunit YajC YP_001428331.2 830415 D 458234 CDS YP_001428332.2 169656579 5523274 830828..832765 1 NC_009749.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 832765 secD 5523274 secD Francisella tularensis subsp. holarctica FTNF002-00 preprotein translocase subunit SecD YP_001428332.2 830828 D 458234 CDS YP_001428333.1 156502268 5523275 832784..833728 1 NC_009749.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 833728 secF 5523275 secF Francisella tularensis subsp. holarctica FTNF002-00 preprotein translocase subunit SecF YP_001428333.1 832784 D 458234 CDS YP_001428334.1 156502269 5523276 833760..834290 1 NC_009749.1 hypothetical protein 834290 5523276 FTA_0902 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428334.1 833760 D 458234 CDS YP_001428335.1 156502270 5523277 834314..835192 1 NC_009749.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 835192 rpoH 5523277 rpoH Francisella tularensis subsp. holarctica FTNF002-00 RNA polymerase factor sigma-32 YP_001428335.1 834314 D 458234 CDS YP_001428336.1 156502271 5523278 835283..836560 1 NC_009749.1 3-phosphoshikimate 1-carboxyvinyltransferase 836560 aroA 5523278 aroA Francisella tularensis subsp. holarctica FTNF002-00 3-phosphoshikimate 1-carboxyvinyltransferase YP_001428336.1 835283 D 458234 CDS YP_001428337.1 156502272 5523279 836563..837153 1 NC_009749.1 hypothetical protein 837153 5523279 FTA_0905 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428337.1 836563 D 458234 CDS YP_001428338.1 156502273 5523280 837128..837586 1 NC_009749.1 RNase H 837586 rnhA 5523280 rnhA Francisella tularensis subsp. holarctica FTNF002-00 RNase H YP_001428338.1 837128 D 458234 CDS YP_001428339.1 156502274 5523281 837588..838625 1 NC_009749.1 L-asparaginase 838625 5523281 FTA_0907 Francisella tularensis subsp. holarctica FTNF002-00 L-asparaginase YP_001428339.1 837588 D 458234 CDS YP_001428340.1 156502275 5523282 838696..839382 1 NC_009749.1 carbonic anhydrase 839382 5523282 FTA_0908 Francisella tularensis subsp. holarctica FTNF002-00 carbonic anhydrase YP_001428340.1 838696 D 458234 CDS YP_001428341.1 156502276 5523283 complement(839669..840274) 1 NC_009749.1 hypothetical protein 840274 5523283 FTA_0909 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428341.1 839669 R 458234 CDS YP_001428342.1 156502277 5523284 complement(840338..841210) 1 NC_009749.1 hypothetical protein 841210 5523284 FTA_0910 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428342.1 840338 R 458234 CDS YP_001428343.1 156502278 5523285 complement(841219..841389) 1 NC_009749.1 rubredoxin 841389 rubA 5523285 rubA Francisella tularensis subsp. holarctica FTNF002-00 rubredoxin YP_001428343.1 841219 R 458234 CDS YP_001428344.1 156502279 5523286 complement(841475..842092) 1 NC_009749.1 hypothetical protein 842092 5523286 FTA_0912 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428344.1 841475 R 458234 CDS YP_001428345.1 156502280 5523503 842367..843026 1 NC_009749.1 transposase ISFTu2 843026 5523503 FTA_0913 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428345.1 842367 D 458234 CDS YP_001428346.1 156502281 5523504 843061..844455 1 NC_009749.1 hypothetical protein 844455 5523504 FTA_0914 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428346.1 843061 D 458234 CDS YP_001428347.2 169656580 5523505 complement(844487..845761) 1 NC_009749.1 sodium-dicarboxylate symporter family protein 845761 5523505 FTA_0915 Francisella tularensis subsp. holarctica FTNF002-00 sodium-dicarboxylate symporter family protein YP_001428347.2 844487 R 458234 CDS YP_001428348.1 156502283 5523506 845963..846991 1 NC_009749.1 sugar isomerase 846991 5523506 FTA_0916 Francisella tularensis subsp. holarctica FTNF002-00 sugar isomerase YP_001428348.1 845963 D 458234 CDS YP_001428349.1 156502284 5523507 847016..848419 1 NC_009749.1 major facilitator superfamily sugar transporter 848419 5523507 FTA_0917 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator superfamily sugar transporter YP_001428349.1 847016 D 458234 CDS YP_001428350.1 156502285 5523508 848807..849115 1 NC_009749.1 putative IS1 transposase 849115 5523508 FTA_0918 Francisella tularensis subsp. holarctica FTNF002-00 putative IS1 transposase YP_001428350.1 848807 D 458234 CDS YP_001428351.1 156502286 5523509 complement(849297..850754) 1 NC_009749.1 hypothetical protein 850754 5523509 FTA_0919 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428351.1 849297 R 458234 CDS YP_001428354.1 156502289 5523512 851896..852135 1 NC_009749.1 hypothetical protein 852135 5523512 FTA_0922 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428354.1 851896 D 458234 CDS YP_001428355.1 156502290 5523513 852195..852374 1 NC_009749.1 hypothetical protein 852374 5523513 FTA_0923 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428355.1 852195 D 458234 CDS YP_001428356.2 169656581 5523514 852840..853340 1 NC_009749.1 hypothetical protein 853340 5523514 FTA_0924 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428356.2 852840 D 458234 CDS YP_001428357.1 156502292 5523515 complement(853852..854094) 1 NC_009749.1 hypothetical protein 854094 5523515 FTA_0925 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428357.1 853852 R 458234 CDS YP_001428358.1 156502293 5523516 854191..855396 1 NC_009749.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 855396 ispG 5523516 ispG Francisella tularensis subsp. holarctica FTNF002-00 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_001428358.1 854191 D 458234 CDS YP_001428359.1 156502294 5522571 855411..856118 1 NC_009749.1 hypothetical protein 856118 5522571 FTA_0927 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428359.1 855411 D 458234 CDS YP_001428360.1 156502295 5522572 856137..857930 1 NC_009749.1 M24 family metallopeptidase 857930 5522572 FTA_0928 Francisella tularensis subsp. holarctica FTNF002-00 M24 family metallopeptidase YP_001428360.1 856137 D 458234 CDS YP_001428361.1 156502297 5522573 858028..859092 1 NC_009749.1 DNA/RNA endonuclease 859092 5522573 FTA_0930 Francisella tularensis subsp. holarctica FTNF002-00 DNA/RNA endonuclease YP_001428361.1 858028 D 458234 CDS YP_001428362.1 156502296 5522575 complement(859083..859946) 1 NC_009749.1 beta-lactamase 859946 5522575 FTA_0929 Francisella tularensis subsp. holarctica FTNF002-00 beta-lactamase YP_001428362.1 859083 R 458234 CDS YP_001428363.1 156502298 5522574 860375..861325 1 NC_009749.1 hypothetical protein 861325 5522574 FTA_0931 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428363.1 860375 D 458234 CDS YP_001428364.1 156502299 5522576 complement(861621..861896) 1 NC_009749.1 hypothetical protein 861896 5522576 FTA_0932 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428364.1 861621 R 458234 CDS YP_001428365.1 156502300 5522577 complement(862142..863632) 1 NC_009749.1 apolipoprotein N-acyltransferase 863632 lnt 5522577 lnt Francisella tularensis subsp. holarctica FTNF002-00 apolipoprotein N-acyltransferase YP_001428365.1 862142 R 458234 CDS YP_001428366.1 156502301 5522578 complement(863632..864474) 1 NC_009749.1 hypothetical protein 864474 5522578 FTA_0934 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428366.1 863632 R 458234 CDS YP_001428367.1 156502302 5522579 complement(864464..864952) 1 NC_009749.1 hypothetical protein 864952 5522579 FTA_0935 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428367.1 864464 R 458234 CDS YP_001428368.2 169656582 5522580 complement(864945..865928) 1 NC_009749.1 PhoH family protein 865928 5522580 FTA_0936 Francisella tularensis subsp. holarctica FTNF002-00 PhoH family protein YP_001428368.2 864945 R 458234 CDS YP_001428369.1 156502304 5522581 complement(865932..867260) 1 NC_009749.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 867260 miaB 5522581 miaB Francisella tularensis subsp. holarctica FTNF002-00 (dimethylallyl)adenosine tRNA methylthiotransferase YP_001428369.1 865932 R 458234 CDS YP_001428370.1 156502305 5522582 867522..868157 1 NC_009749.1 o-methyltransferase family protein 868157 5522582 FTA_0938 Francisella tularensis subsp. holarctica FTNF002-00 o-methyltransferase family protein YP_001428370.1 867522 D 458234 CDS YP_001428373.2 169656583 5523087 868925..869518 1 NC_009749.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 869518 tdk 5523087 tdk Francisella tularensis subsp. holarctica FTNF002-00 thymidine kinase YP_001428373.2 868925 D 458234 CDS YP_001428374.1 156502309 5523088 870181..871497 1 NC_009749.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 871497 tig 5523088 tig Francisella tularensis subsp. holarctica FTNF002-00 trigger factor YP_001428374.1 870181 D 458234 CDS YP_001428375.1 156502310 5523089 871523..872128 1 NC_009749.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 872128 clpP 5523089 clpP Francisella tularensis subsp. holarctica FTNF002-00 ATP-dependent Clp protease proteolytic subunit YP_001428375.1 871523 D 458234 CDS YP_001428376.1 156502311 5523090 872152..873405 1 NC_009749.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 873405 clpX 5523090 clpX Francisella tularensis subsp. holarctica FTNF002-00 ATP-dependent protease ATP-binding subunit ClpX YP_001428376.1 872152 D 458234 CDS YP_001428377.1 156502312 5523091 873430..875754 1 NC_009749.1 DNA-binding, ATP-dependent protease La 875754 lon 5523091 lon Francisella tularensis subsp. holarctica FTNF002-00 DNA-binding, ATP-dependent protease La YP_001428377.1 873430 D 458234 CDS YP_001428378.1 156502313 5523092 875841..876113 1 NC_009749.1 DNA-binding protein HU 876113 5523092 FTA_0946 Francisella tularensis subsp. holarctica FTNF002-00 DNA-binding protein HU YP_001428378.1 875841 D 458234 CDS YP_001428379.1 156502314 5523093 876226..877659 1 NC_009749.1 hypothetical protein 877659 5523093 FTA_0947 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428379.1 876226 D 458234 CDS YP_001428380.1 156502315 5523094 877660..878586 1 NC_009749.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 878586 miaA 5523094 miaA Francisella tularensis subsp. holarctica FTNF002-00 tRNA delta(2)-isopentenylpyrophosphate transferase YP_001428380.1 877660 D 458234 CDS YP_001428381.1 156502316 5523095 878697..879026 1 NC_009749.1 host factor I for bacteriophage Q beta replication 879026 5523095 FTA_0949 Francisella tularensis subsp. holarctica FTNF002-00 host factor I for bacteriophage Q beta replication YP_001428381.1 878697 D 458234 CDS YP_001428382.1 156502317 5523096 879174..880385 1 NC_009749.1 protease, GTP-binding subunit 880385 5523096 FTA_0950 Francisella tularensis subsp. holarctica FTNF002-00 protease, GTP-binding subunit YP_001428382.1 879174 D 458234 CDS YP_001428386.1 156502321 5523100 881758..882825 1 NC_009749.1 protease regulator HflK 882825 hflK 5523100 hflK Francisella tularensis subsp. holarctica FTNF002-00 protease regulator HflK YP_001428386.1 881758 D 458234 CDS YP_001428387.1 156502322 5524203 882827..883753 1 NC_009749.1 protease regulator HflC 883753 hflC 5524203 hflC Francisella tularensis subsp. holarctica FTNF002-00 protease regulator HflC YP_001428387.1 882827 D 458234 CDS YP_001428388.1 156502323 5524204 883754..884239 1 NC_009749.1 low molecular weight (LMW) phosphotyrosine protein phosphatase 884239 5524204 FTA_0956 Francisella tularensis subsp. holarctica FTNF002-00 low molecular weight (LMW) phosphotyrosine protein phosphatase YP_001428388.1 883754 D 458234 CDS YP_001428389.2 169656584 5524205 884236..884829 1 NC_009749.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 884829 engB 5524205 engB Francisella tularensis subsp. holarctica FTNF002-00 ribosome biogenesis GTP-binding protein YsxC YP_001428389.2 884236 D 458234 CDS YP_001428392.1 156502327 5524208 886267..886617 1 NC_009749.1 hypothetical protein 886617 5524208 FTA_0960 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428392.1 886267 D 458234 CDS YP_001428397.2 169656585 5524213 889878..890195 1 NC_009749.1 acetolactate synthase small subunit 890195 5524213 FTA_0965 Francisella tularensis subsp. holarctica FTNF002-00 acetolactate synthase small subunit YP_001428397.2 889878 D 458234 CDS YP_001428398.1 156502333 5524214 890223..891266 1 NC_009749.1 ketol-acid reductoisomerase 891266 ilvC 5524214 ilvC Francisella tularensis subsp. holarctica FTNF002-00 ketol-acid reductoisomerase YP_001428398.1 890223 D 458234 CDS YP_001428399.1 156502334 5524215 complement(891389..894814) 1 NC_009749.1 transcription-repair coupling factor 894814 mfd 5524215 mfd Francisella tularensis subsp. holarctica FTNF002-00 transcription-repair coupling factor YP_001428399.1 891389 R 458234 CDS YP_001428400.2 169656586 5524216 complement(894859..895545) 1 NC_009749.1 hypothetical protein 895545 5524216 FTA_0968 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428400.2 894859 R 458234 CDS YP_001428401.1 156502336 5523545 complement(895661..896920) 1 NC_009749.1 hypothetical protein 896920 5523545 FTA_0969 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428401.1 895661 R 458234 CDS YP_001428402.1 156502337 5523546 complement(896920..897351) 1 NC_009749.1 hypothetical protein 897351 5523546 FTA_0970 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428402.1 896920 R 458234 CDS YP_001428403.1 156502338 5523547 complement(897348..897986) 1 NC_009749.1 endonuclease III 897986 nth 5523547 nth Francisella tularensis subsp. holarctica FTNF002-00 endonuclease III YP_001428403.1 897348 R 458234 CDS YP_001428404.1 156502339 5523548 complement(897979..898608) 1 NC_009749.1 RnfABCDGE type electron transport complex subunit B 898608 5523548 FTA_0972 Francisella tularensis subsp. holarctica FTNF002-00 RnfABCDGE type electron transport complex subunit B YP_001428404.1 897979 R 458234 CDS YP_001428405.2 169656587 5523549 complement(898610..899254) 1 NC_009749.1 cofactor involved in the reduction of disulfides; glutaredoxin 899254 5523549 FTA_0973 Francisella tularensis subsp. holarctica FTNF002-00 glutaredoxin YP_001428405.2 898610 R 458234 CDS YP_001428408.1 156502343 5523552 complement(900886..901386) 1 NC_009749.1 ferritin-like protein 901386 5523552 FTA_0976 Francisella tularensis subsp. holarctica FTNF002-00 ferritin-like protein YP_001428408.1 900886 R 458234 CDS YP_001428409.1 156502344 5523553 901592..902575 1 NC_009749.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 902575 lipA 5523553 lipA Francisella tularensis subsp. holarctica FTNF002-00 lipoyl synthase YP_001428409.1 901592 D 458234 CDS YP_001428410.1 156502345 5523554 902605..903264 1 NC_009749.1 isoprenoid biosynthesis protein with amidotransferase-like domain 903264 5523554 FTA_0978 Francisella tularensis subsp. holarctica FTNF002-00 isoprenoid biosynthesis protein with amidotransferase-like domain YP_001428410.1 902605 D 458234 CDS YP_001428411.1 156502346 5523555 903280..904026 1 NC_009749.1 hypothetical protein 904026 5523555 FTA_0979 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428411.1 903280 D 458234 CDS YP_001428412.1 156502347 5523556 904123..904638 1 NC_009749.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 904638 ruvC 5523556 ruvC Francisella tularensis subsp. holarctica FTNF002-00 Holliday junction resolvase YP_001428412.1 904123 D 458234 CDS YP_001428413.1 156502348 5523557 904720..905910 1 NC_009749.1 major facilitator transporter 905910 5523557 FTA_0981 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001428413.1 904720 D 458234 CDS YP_001428414.1 156502349 5523558 905923..906573 1 NC_009749.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 906573 ruvA 5523558 ruvA Francisella tularensis subsp. holarctica FTNF002-00 Holliday junction DNA helicase RuvA YP_001428414.1 905923 D 458234 CDS YP_001428415.1 156502350 5523259 906599..908014 1 NC_009749.1 DNA recombination protein 908014 5523259 FTA_0983 Francisella tularensis subsp. holarctica FTNF002-00 DNA recombination protein YP_001428415.1 906599 D 458234 CDS YP_001428416.1 156502351 5523260 908193..908642 1 NC_009749.1 N terminal truncation compared to Schu4 and WY96-3418 ORFs; hypothetical protein 908642 5523260 FTA_0984 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428416.1 908193 D 458234 CDS YP_001428417.1 156502352 5523261 complement(908996..909337) 1 NC_009749.1 N-terminal truncation compared to balst hits; hypothetical protein 909337 5523261 FTA_0985 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428417.1 908996 R 458234 CDS YP_001428418.1 156502354 5523262 909616..910428 1 NC_009749.1 hypothetical protein 910428 5523262 FTA_0987 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428418.1 909616 D 458234 CDS YP_001428419.1 156502353 5523264 complement(910415..911551) 1 NC_009749.1 catalyzes the formation of histamine from L-histidine; histidine decarboxylase 911551 5523264 FTA_0986 Francisella tularensis subsp. holarctica FTNF002-00 histidine decarboxylase YP_001428419.1 910415 R 458234 CDS YP_001428420.1 156502355 5523263 complement(911566..912264) 1 NC_009749.1 aldolase/adducin class II family protein 912264 5523263 FTA_0988 Francisella tularensis subsp. holarctica FTNF002-00 aldolase/adducin class II family protein YP_001428420.1 911566 R 458234 CDS YP_001428421.1 156502356 5523265 complement(912355..912936) 1 NC_009749.1 3-methyladenine DNA glycosylase 912936 5523265 FTA_0989 Francisella tularensis subsp. holarctica FTNF002-00 3-methyladenine DNA glycosylase YP_001428421.1 912355 R 458234 CDS YP_001428422.2 169656588 5523266 913064..913567 1 NC_009749.1 hypothetical protein 913567 5523266 FTA_0990 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428422.2 913064 D 458234 CDS YP_001428423.1 156502358 5523267 913567..914199 1 NC_009749.1 nicotinamide mononucleotide transporter 914199 5523267 FTA_0991 Francisella tularensis subsp. holarctica FTNF002-00 nicotinamide mononucleotide transporter YP_001428423.1 913567 D 458234 CDS YP_001428424.2 169656589 5523268 914302..915477 1 NC_009749.1 monovalent cation:proton antiporter-2 (CPA2) family protein 915477 5523268 FTA_0992 Francisella tularensis subsp. holarctica FTNF002-00 monovalent cation:proton antiporter-2 (CPA2) family protein YP_001428424.2 914302 D 458234 CDS YP_001428425.2 169656590 5523269 complement(915810..916271) 1 NC_009749.1 hypothetical protein 916271 5523269 FTA_0993 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428425.2 915810 R 458234 CDS YP_001428430.2 169656591 5523000 complement(919146..920078) 1 NC_009749.1 succinylglutamate desuccinylase/aspartoacylase family protein 920078 5523000 FTA_0998 Francisella tularensis subsp. holarctica FTNF002-00 succinylglutamate desuccinylase/aspartoacylase family protein YP_001428430.2 919146 R 458234 CDS YP_001428431.1 156502366 5523001 920363..921331 1 NC_009749.1 ribose-phosphate pyrophosphokinase 921331 5523001 FTA_0999 Francisella tularensis subsp. holarctica FTNF002-00 ribose-phosphate pyrophosphokinase YP_001428431.1 920363 D 458234 CDS YP_001428432.1 156502367 5523002 921431..921721 1 NC_009749.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 921721 5523002 FTA_1000 Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L25 YP_001428432.1 921431 D 458234 CDS YP_001428433.1 156502368 5523003 921817..923076 1 NC_009749.1 hypothetical protein 923076 5523003 FTA_1001 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428433.1 921817 D 458234 CDS YP_001428437.1 156502372 5523007 complement(924672..924947) 1 NC_009749.1 hypothetical protein 924947 5523007 FTA_1005 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428437.1 924672 R 458234 CDS YP_001428438.1 156502373 5523008 complement(924962..926053) 1 NC_009749.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 926053 5523008 FTA_1006 Francisella tularensis subsp. holarctica FTNF002-00 GTP-dependent nucleic acid-binding protein EngD YP_001428438.1 924962 R 458234 CDS YP_001428439.2 169656592 5523009 complement(926072..926647) 1 NC_009749.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 926647 pth 5523009 pth Francisella tularensis subsp. holarctica FTNF002-00 peptidyl-tRNA hydrolase YP_001428439.2 926072 R 458234 CDS YP_001428440.1 156502375 5523010 complement(926640..927524) 1 NC_009749.1 beta-lactamase family protein 927524 5523010 FTA_1008 Francisella tularensis subsp. holarctica FTNF002-00 beta-lactamase family protein YP_001428440.1 926640 R 458234 CDS YP_001428441.1 156502376 5523011 complement(927533..928378) 1 NC_009749.1 hypothetical protein 928378 5523011 FTA_1009 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428441.1 927533 R 458234 CDS YP_001428442.2 169656593 5523012 complement(928418..929236) 1 NC_009749.1 prepilin peptidase family protein 929236 5523012 FTA_1010 Francisella tularensis subsp. holarctica FTNF002-00 prepilin peptidase family protein YP_001428442.2 928418 R 458234 CDS YP_001428443.2 169656594 5523434 complement(929240..930655) 1 NC_009749.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 930655 udhA 5523434 udhA Francisella tularensis subsp. holarctica FTNF002-00 soluble pyridine nucleotide transhydrogenase YP_001428443.2 929240 R 458234 CDS YP_001428446.1 156502381 5523437 complement(931971..933428) 1 NC_009749.1 amino acid transporter 933428 5523437 FTA_1014 Francisella tularensis subsp. holarctica FTNF002-00 amino acid transporter YP_001428446.1 931971 R 458234 CDS YP_001428447.1 156502382 5523438 complement(933526..934893) 1 NC_009749.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 934893 hslU 5523438 hslU Francisella tularensis subsp. holarctica FTNF002-00 ATP-dependent protease ATP-binding subunit HslU YP_001428447.1 933526 R 458234 CDS YP_001428448.1 156502383 5523439 complement(934901..935473) 1 NC_009749.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 935473 5523439 FTA_1016 Francisella tularensis subsp. holarctica FTNF002-00 ATP-dependent protease peptidase subunit YP_001428448.1 934901 R 458234 CDS YP_001428449.1 156502384 5523440 935644..936393 1 NC_009749.1 hypothetical protein 936393 5523440 FTA_1017 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428449.1 935644 D 458234 CDS YP_001428450.1 156502385 5523441 complement(936396..937298) 1 NC_009749.1 lipoate-protein ligase /lipoyltransferase 937298 5523441 FTA_1018 Francisella tularensis subsp. holarctica FTNF002-00 lipoate-protein ligase /lipoyltransferase YP_001428450.1 936396 R 458234 CDS YP_001428451.2 169656595 5523442 937361..938602 1 NC_009749.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 938602 tyrS 5523442 tyrS Francisella tularensis subsp. holarctica FTNF002-00 tyrosyl-tRNA synthetase YP_001428451.2 937361 D 458234 CDS YP_001428452.2 169656596 5523443 complement(join(939006..939557,939557..939886)) 1 NC_009749.1 programmed frameshift; transposase ISFtu1 939886 5523443 FTA_1020 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001428452.2 939006 R 458234 CDS YP_001428454.1 156502389 5523445 939954..941123 1 NC_009749.1 FMN dependent dehydrogenase 941123 5523445 FTA_1022 Francisella tularensis subsp. holarctica FTNF002-00 FMN dependent dehydrogenase YP_001428454.1 939954 D 458234 CDS YP_001428455.1 156502390 5523446 941146..941322 1 NC_009749.1 hypothetical protein 941322 5523446 FTA_1023 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428455.1 941146 D 458234 CDS YP_001428458.1 156502393 5523748 944267..945424 1 NC_009749.1 iron-containing alcohol dehydrogenase 945424 5523748 FTA_1026 Francisella tularensis subsp. holarctica FTNF002-00 iron-containing alcohol dehydrogenase YP_001428458.1 944267 D 458234 CDS YP_001428459.1 156502394 5523749 945647..946492 1 NC_009749.1 50S ribosomal protein L11 methyltransferase 946492 prmA 5523749 prmA Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L11 methyltransferase YP_001428459.1 945647 D 458234 CDS YP_001428460.1 156502395 5523750 946482..947465 1 NC_009749.1 tRNA-dihydrouridine synthase, TIM-barrel family protein 947465 5523750 FTA_1028 Francisella tularensis subsp. holarctica FTNF002-00 tRNA-dihydrouridine synthase, TIM-barrel family protein YP_001428460.1 946482 D 458234 CDS YP_001428461.1 156502396 5523751 947695..950022 1 NC_009749.1 putative N-6 DNA methylase 950022 5523751 FTA_1029 Francisella tularensis subsp. holarctica FTNF002-00 putative N-6 DNA methylase YP_001428461.1 947695 D 458234 CDS YP_001428462.1 156502397 5523752 950264..950650 1 NC_009749.1 hypothetical protein 950650 5523752 FTA_1030 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428462.1 950264 D 458234 CDS YP_001428464.1 156502399 5523754 951039..951353 1 NC_009749.1 N-terminal truncation compared to Schu4 or WY96-3418 ORFs; hypothetical protein 951353 5523754 FTA_1032 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428464.1 951039 D 458234 CDS YP_001428465.1 156502400 5523755 951359..952771 1 NC_009749.1 hypothetical protein 952771 5523755 FTA_1033 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428465.1 951359 D 458234 CDS YP_001428466.1 156502401 5523756 complement(952791..953840) 1 NC_009749.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 953840 5523756 FTA_1034 Francisella tularensis subsp. holarctica FTNF002-00 DNA polymerase IV YP_001428466.1 952791 R 458234 CDS YP_001428467.1 156502402 5523757 complement(953847..954449) 1 NC_009749.1 DJ-1/PfpI family protein 954449 5523757 FTA_1035 Francisella tularensis subsp. holarctica FTNF002-00 DJ-1/PfpI family protein YP_001428467.1 953847 R 458234 CDS YP_001428468.1 156502404 5523758 954560..955606 1 NC_009749.1 ABC transporter ATP-binding protein 955606 5523758 FTA_1037 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter ATP-binding protein YP_001428468.1 954560 D 458234 CDS YP_001428469.1 156502403 5523760 complement(955603..956835) 1 NC_009749.1 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta 956835 5523760 FTA_1036 Francisella tularensis subsp. holarctica FTNF002-00 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta YP_001428469.1 955603 R 458234 CDS YP_001428470.1 156502405 5523759 complement(956842..957102) 1 NC_009749.1 glutaredoxin 957102 5523759 FTA_1038 Francisella tularensis subsp. holarctica FTNF002-00 glutaredoxin YP_001428470.1 956842 R 458234 CDS YP_001428471.1 156502406 5523488 complement(957106..958878) 1 NC_009749.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 958878 nrdA 5523488 nrdA Francisella tularensis subsp. holarctica FTNF002-00 ribonucleotide-diphosphate reductase subunit alpha YP_001428471.1 957106 R 458234 CDS YP_001428472.2 169656597 5523489 complement(959082..960041) 1 NC_009749.1 Catalyzes the reversible oxidation of malate to oxaloacetate; malate dehydrogenase 960041 mdh 5523489 mdh Francisella tularensis subsp. holarctica FTNF002-00 malate dehydrogenase YP_001428472.2 959082 R 458234 CDS YP_001428473.2 169656598 5523490 960201..960716 1 NC_009749.1 hypothetical protein 960716 5523490 FTA_1041 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428473.2 960201 D 458234 CDS YP_001428474.1 156502409 5523491 960732..961367 1 NC_009749.1 ubiquinone biosynthesis protein 961367 5523491 FTA_1042 Francisella tularensis subsp. holarctica FTNF002-00 ubiquinone biosynthesis protein YP_001428474.1 960732 D 458234 CDS YP_001428475.1 156502410 5523492 complement(961376..961945) 1 NC_009749.1 transglycosylase 961945 5523492 FTA_1043 Francisella tularensis subsp. holarctica FTNF002-00 transglycosylase YP_001428475.1 961376 R 458234 CDS YP_001428477.2 169656599 5523494 join(962568..962897,962897..963448) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 963448 5523494 FTA_1045 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001428477.2 962568 D 458234 CDS YP_001428480.1 156502415 5523497 complement(963733..965223) 1 NC_009749.1 hypothetical protein 965223 5523497 FTA_1048 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428480.1 963733 R 458234 CDS YP_001428481.1 156502416 5523498 complement(965278..965877) 1 NC_009749.1 HAD superfamily hydrolase 965877 5523498 FTA_1049 Francisella tularensis subsp. holarctica FTNF002-00 HAD superfamily hydrolase YP_001428481.1 965278 R 458234 CDS YP_001428482.1 156502417 5523499 965955..966554 1 NC_009749.1 anti-oxidant AhpCTSA family protein 966554 5523499 FTA_1050 Francisella tularensis subsp. holarctica FTNF002-00 anti-oxidant AhpCTSA family protein YP_001428482.1 965955 D 458234 CDS YP_001428484.2 169656600 5523501 967189..967995 1 NC_009749.1 N-terminal truncation compared to Schu4 and WY96-3418; hypothetical protein 967995 5523501 FTA_1052 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428484.2 967189 D 458234 CDS YP_001428485.2 169656601 5523502 968101..968367 1 NC_009749.1 C-terminal truncation compared to blast hits; putative alkylphosphonate utilization operon protein 968367 5523502 FTA_1053 Francisella tularensis subsp. holarctica FTNF002-00 putative alkylphosphonate utilization operon protein YP_001428485.2 968101 D 458234 CDS YP_001428486.1 156502421 5523302 968440..968655 1 NC_009749.1 hypothetical protein 968655 5523302 FTA_1054 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428486.1 968440 D 458234 CDS YP_001428487.1 156502422 5523303 969064..969270 1 NC_009749.1 Shorter ORF compared other Francsisella orthologs; hypothetical protein 969270 5523303 FTA_1055 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428487.1 969064 D 458234 CDS YP_001428488.1 156502423 5523304 969388..970158 1 NC_009749.1 N-terminal truncated compared to orthologs; hypothetical protein 970158 5523304 FTA_1056 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428488.1 969388 D 458234 CDS YP_001428489.2 169656602 5523305 970188..970904 1 NC_009749.1 DNA polymerase III subunit epsilon 970904 dnaQ 5523305 dnaQ Francisella tularensis subsp. holarctica FTNF002-00 DNA polymerase III subunit epsilon YP_001428489.2 970188 D 458234 CDS YP_001428490.1 156502425 5523306 970898..971371 1 NC_009749.1 D-alanyl-D-alanine carboxypeptidase 971371 5523306 FTA_1058 Francisella tularensis subsp. holarctica FTNF002-00 D-alanyl-D-alanine carboxypeptidase YP_001428490.1 970898 D 458234 CDS YP_001428491.2 169656603 5523307 971313..972767 1 NC_009749.1 hypothetical protein 972767 5523307 FTA_1059 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428491.2 971313 D 458234 CDS YP_001428496.1 156502431 5523312 974216..974677 1 NC_009749.1 C-terminal truncated protein; putative NAD-dependent aldehyde dehydrogenase fragment 974677 5523312 FTA_1064 Francisella tularensis subsp. holarctica FTNF002-00 putative NAD-dependent aldehyde dehydrogenase fragment YP_001428496.1 974216 D 458234 CDS YP_001428499.1 156502434 5523315 975241..975513 1 NC_009749.1 hypothetical protein 975513 5523315 FTA_1067 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428499.1 975241 D 458234 CDS YP_001428500.1 156502435 5523316 975527..976258 1 NC_009749.1 hypothetical protein 976258 5523316 FTA_1068 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428500.1 975527 D 458234 CDS YP_001428501.1 156502436 5523559 complement(976261..977130) 1 NC_009749.1 oxidative stress transcriptional regulator 977130 5523559 FTA_1069 Francisella tularensis subsp. holarctica FTNF002-00 oxidative stress transcriptional regulator YP_001428501.1 976261 R 458234 CDS YP_001428502.1 156502437 5523560 977228..977752 1 NC_009749.1 AhpC/TSA family protein 977752 5523560 FTA_1070 Francisella tularensis subsp. holarctica FTNF002-00 AhpC/TSA family protein YP_001428502.1 977228 D 458234 CDS YP_001428503.1 156502438 5523561 977755..978366 1 NC_009749.1 short chain dehydrogenase 978366 5523561 FTA_1071 Francisella tularensis subsp. holarctica FTNF002-00 short chain dehydrogenase YP_001428503.1 977755 D 458234 CDS YP_001428504.2 169656604 5523562 complement(978383..979087) 1 NC_009749.1 cytidylate kinase 979087 cmk 5523562 cmk Francisella tularensis subsp. holarctica FTNF002-00 cytidylate kinase YP_001428504.2 978383 R 458234 CDS YP_001428505.1 156502440 5523563 complement(979035..980087) 1 NC_009749.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 980087 serC 5523563 serC Francisella tularensis subsp. holarctica FTNF002-00 phosphoserine aminotransferase YP_001428505.1 979035 R 458234 CDS YP_001428508.2 169656605 5523566 join(980407..980736,980736..981287) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 981287 5523566 FTA_1077 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001428508.2 980407 D 458234 CDS YP_001428509.1 156502443 5523568 complement(981265..982320) 1 NC_009749.1 histidine acid phosphatase 982320 5523568 FTA_1076 Francisella tularensis subsp. holarctica FTNF002-00 histidine acid phosphatase YP_001428509.1 981265 R 458234 CDS YP_001428510.1 156502445 5523567 complement(982345..983271) 1 NC_009749.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 983271 hemF 5523567 hemF Francisella tularensis subsp. holarctica FTNF002-00 coproporphyrinogen III oxidase YP_001428510.1 982345 R 458234 CDS YP_001428513.2 169656606 5523571 984778..985140 1 NC_009749.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 985140 rpsF 5523571 rpsF Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S6 YP_001428513.2 984778 D 458234 CDS YP_001428514.2 169656607 5523572 985156..985374 1 NC_009749.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 985374 rpsR 5523572 rpsR Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S18 YP_001428514.2 985156 D 458234 CDS YP_001428515.2 169656608 5523573 985384..985848 1 NC_009749.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 985848 rplI 5523573 rplI Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L9 YP_001428515.2 985384 D 458234 CDS YP_001428516.2 169656609 5523028 985936..987333 1 NC_009749.1 replicative DNA helicase 987333 dnaB 5523028 dnaB Francisella tularensis subsp. holarctica FTNF002-00 replicative DNA helicase YP_001428516.2 985936 D 458234 CDS YP_001428517.1 156502452 5523029 987364..988476 1 NC_009749.1 radical SAM protein 988476 5523029 FTA_1085 Francisella tularensis subsp. holarctica FTNF002-00 radical SAM protein YP_001428517.1 987364 D 458234 CDS YP_001428518.2 169656610 5523030 988409..989371 1 NC_009749.1 hypothetical protein 989371 5523030 FTA_1086 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428518.2 988409 D 458234 CDS YP_001428519.1 156502454 5523031 989364..990179 1 NC_009749.1 RNA pseudouridine synthase B 990179 5523031 FTA_1087 Francisella tularensis subsp. holarctica FTNF002-00 RNA pseudouridine synthase B YP_001428519.1 989364 D 458234 CDS YP_001428520.1 156502455 5523032 990179..990604 1 NC_009749.1 hypothetical protein 990604 5523032 FTA_1088 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428520.1 990179 D 458234 CDS YP_001428521.1 156502456 5523033 990582..991022 1 NC_009749.1 acetyltransferase 991022 5523033 FTA_1089 Francisella tularensis subsp. holarctica FTNF002-00 acetyltransferase YP_001428521.1 990582 D 458234 CDS YP_001428522.1 156502457 5523034 991148..991627 1 NC_009749.1 C-terminal truncation due to preamture stop; hypothetical protein 991627 5523034 FTA_1090 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428522.1 991148 D 458234 CDS YP_001428523.1 156502458 5523035 992400..992537 1 NC_009749.1 hypothetical protein 992537 5523035 FTA_1091 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428523.1 992400 D 458234 CDS YP_001428524.2 169656611 5523036 992798..993004 1 NC_009749.1 hypothetical protein 993004 5523036 FTA_1092 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428524.2 992798 D 458234 CDS YP_001428525.2 169656612 5523037 993450..993602 1 NC_009749.1 hypothetical protein 993602 5523037 FTA_1093 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428525.2 993450 D 458234 CDS YP_001428530.1 156502465 5523042 997112..997477 1 NC_009749.1 hypothetical protein 997477 5523042 FTA_1098 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428530.1 997112 D 458234 CDS YP_001428531.1 156502466 5523704 998144..998767 1 NC_009749.1 hypothetical protein 998767 5523704 FTA_1099 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428531.1 998144 D 458234 CDS YP_001428532.1 156502467 5523705 998848..999279 1 NC_009749.1 hypothetical protein 999279 5523705 FTA_1100 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428532.1 998848 D 458234 CDS YP_001428533.1 156502468 5523706 999369..1000346 1 NC_009749.1 polyprenyl synthetase family protein 1000346 5523706 FTA_1101 Francisella tularensis subsp. holarctica FTNF002-00 polyprenyl synthetase family protein YP_001428533.1 999369 D 458234 CDS YP_001428534.1 156502469 5523707 complement(1000364..1001176) 1 NC_009749.1 FKBP-type peptidyl-prolyl cis-trans isomerase 1001176 5523707 FTA_1102 Francisella tularensis subsp. holarctica FTNF002-00 FKBP-type peptidyl-prolyl cis-trans isomerase YP_001428534.1 1000364 R 458234 CDS YP_001428535.1 156502470 5523708 complement(1001190..1001993) 1 NC_009749.1 hypothetical protein 1001993 5523708 FTA_1103 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428535.1 1001190 R 458234 CDS YP_001428536.1 156502471 5523709 complement(1001986..1002402) 1 NC_009749.1 hypothetical protein 1002402 5523709 FTA_1104 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428536.1 1001986 R 458234 CDS YP_001428537.1 156502472 5523710 complement(1002418..1003029) 1 NC_009749.1 lipoprotein 1003029 5523710 FTA_1105 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001428537.1 1002418 R 458234 CDS YP_001428538.1 156502473 5523711 complement(1003030..1004433) 1 NC_009749.1 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase 1004433 dacB 5523711 dacB Francisella tularensis subsp. holarctica FTNF002-00 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase YP_001428538.1 1003030 R 458234 CDS YP_001428539.1 156502474 5523712 1004689..1004886 1 NC_009749.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1004886 rpsU 5523712 rpsU Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S21 YP_001428539.1 1004689 D 458234 CDS YP_001428540.1 156502475 5523713 1004947..1005393 1 NC_009749.1 GatB/Yqey domain-containing protein 1005393 5523713 FTA_1108 Francisella tularensis subsp. holarctica FTNF002-00 GatB/Yqey domain-containing protein YP_001428540.1 1004947 D 458234 CDS YP_001428541.1 156502476 5523714 1005414..1007231 1 NC_009749.1 DNA primase 1007231 dnaG 5523714 dnaG Francisella tularensis subsp. holarctica FTNF002-00 DNA primase YP_001428541.1 1005414 D 458234 CDS YP_001428542.1 156502477 5523715 1007256..1008989 1 NC_009749.1 RNA polymerase sigma-70 factor 1008989 rpoD 5523715 rpoD Francisella tularensis subsp. holarctica FTNF002-00 RNA polymerase sigma-70 factor YP_001428542.1 1007256 D 458234 CDS YP_001428543.1 156502478 5523716 1009096..1010346 1 NC_009749.1 NADH dehydrogenase 1010346 5523716 FTA_1111 Francisella tularensis subsp. holarctica FTNF002-00 NADH dehydrogenase YP_001428543.1 1009096 D 458234 CDS YP_001428549.1 156502484 5524161 complement(1014404..1015024) 1 NC_009749.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 1015024 lipB 5524161 lipB Francisella tularensis subsp. holarctica FTNF002-00 lipoate-protein ligase B YP_001428549.1 1014404 R 458234 CDS YP_001428550.2 169656613 5524162 complement(1015034..1015318) 1 NC_009749.1 hypothetical protein 1015318 5524162 FTA_1118 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428550.2 1015034 R 458234 CDS YP_001428551.1 156502486 5524163 complement(1015351..1016685) 1 NC_009749.1 D-alanyl-D-alanine carboxypeptidase 1016685 5524163 FTA_1119 Francisella tularensis subsp. holarctica FTNF002-00 D-alanyl-D-alanine carboxypeptidase YP_001428551.1 1015351 R 458234 CDS YP_001428552.1 156502487 5524164 1016842..1017363 1 NC_009749.1 inorganic pyrophosphatase 1017363 ppa 5524164 ppa Francisella tularensis subsp. holarctica FTNF002-00 inorganic pyrophosphatase YP_001428552.1 1016842 D 458234 CDS YP_001428553.2 169656614 5524165 1017454..1018002 1 NC_009749.1 YrbI family phosphatase 1018002 5524165 FTA_1121 Francisella tularensis subsp. holarctica FTNF002-00 YrbI family phosphatase YP_001428553.2 1017454 D 458234 CDS YP_001428555.1 156502490 5524167 1018623..1019456 1 NC_009749.1 hypothetical protein 1019456 5524167 FTA_1123 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428555.1 1018623 D 458234 CDS YP_001428556.1 156502491 5524168 1019530..1020261 1 NC_009749.1 ABC transporter ATP-binding protein 1020261 5524168 FTA_1124 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter ATP-binding protein YP_001428556.1 1019530 D 458234 CDS YP_001428557.1 156502492 5524169 1020310..1020903 1 NC_009749.1 fumarylacetoacetate hydrolase family protein 1020903 5524169 FTA_1125 Francisella tularensis subsp. holarctica FTNF002-00 fumarylacetoacetate hydrolase family protein YP_001428557.1 1020310 D 458234 CDS YP_001428558.1 156502493 5524170 1020916..1022748 1 NC_009749.1 possible bifunctional protein; phosphorylase family 2 protein 1022748 5524170 FTA_1126 Francisella tularensis subsp. holarctica FTNF002-00 phosphorylase family 2 protein YP_001428558.1 1020916 D 458234 CDS YP_001428559.1 156502494 5524171 1022751..1023527 1 NC_009749.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1023527 truA 5524171 truA Francisella tularensis subsp. holarctica FTNF002-00 tRNA pseudouridine synthase A YP_001428559.1 1022751 D 458234 CDS YP_001428562.1 156502497 5524120 1025214..1026764 1 NC_009749.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1026764 guaA 5524120 guaA Francisella tularensis subsp. holarctica FTNF002-00 GMP synthase YP_001428562.1 1025214 D 458234 CDS YP_001428563.1 156502498 5524121 1026846..1028693 1 NC_009749.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1028693 dxs 5524121 dxs Francisella tularensis subsp. holarctica FTNF002-00 1-deoxy-D-xylulose-5-phosphate synthase YP_001428563.1 1026846 D 458234 CDS YP_001428564.1 156502499 5524122 1028709..1029044 1 NC_009749.1 hypothetical protein 1029044 5524122 FTA_1132 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428564.1 1028709 D 458234 CDS YP_001428565.1 156502500 5524123 1029066..1029695 1 NC_009749.1 GDSL-like lipase/ acylhydrolase 1029695 5524123 FTA_1133 Francisella tularensis subsp. holarctica FTNF002-00 GDSL-like lipase/ acylhydrolase YP_001428565.1 1029066 D 458234 CDS YP_001428566.1 156502501 5524124 complement(1029705..1030295) 1 NC_009749.1 hypothetical protein 1030295 5524124 FTA_1134 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428566.1 1029705 R 458234 CDS YP_001428567.1 156502502 5524125 1030413..1031138 1 NC_009749.1 short chain dehydrogenase family protein 1031138 5524125 FTA_1135 Francisella tularensis subsp. holarctica FTNF002-00 short chain dehydrogenase family protein YP_001428567.1 1030413 D 458234 CDS YP_001428568.1 156502503 5524126 1031202..1032248 1 NC_009749.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1032248 ruvB 5524126 ruvB Francisella tularensis subsp. holarctica FTNF002-00 Holliday junction DNA helicase RuvB YP_001428568.1 1031202 D 458234 CDS YP_001428570.1 156502505 5524128 complement(1033228..1033416) 1 NC_009749.1 hypothetical protein 1033416 5524128 FTA_1138 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428570.1 1033228 R 458234 CDS YP_001428571.1 156502506 5524129 complement(1033528..1033731) 1 NC_009749.1 helix-turn-helix domain-containing protein 1033731 5524129 FTA_1139 Francisella tularensis subsp. holarctica FTNF002-00 helix-turn-helix domain-containing protein YP_001428571.1 1033528 R 458234 CDS YP_001428579.1 156502514 5524106 complement(1036823..1037176) 1 NC_009749.1 hypothetical protein 1037176 5524106 FTA_1147 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428579.1 1036823 R 458234 CDS YP_001428580.1 156502515 5524108 complement(1037554..1038309) 1 NC_009749.1 linear amide C-N hydrolase/choloylglycine hydrolase family protein 1038309 5524108 FTA_1148 Francisella tularensis subsp. holarctica FTNF002-00 linear amide C-N hydrolase/choloylglycine hydrolase family protein YP_001428580.1 1037554 R 458234 CDS YP_001428581.1 156502516 5524109 complement(1038403..1039155) 1 NC_009749.1 rRNA methyltransferase 1039155 5524109 FTA_1149 Francisella tularensis subsp. holarctica FTNF002-00 rRNA methyltransferase YP_001428581.1 1038403 R 458234 CDS YP_001428584.1 156502518 5524113 complement(1041244..1041720) 1 NC_009749.1 tryptophan-rich sensory (TspO)/MBR family protein 1041720 5524113 FTA_1151 Francisella tularensis subsp. holarctica FTNF002-00 tryptophan-rich sensory (TspO)/MBR family protein YP_001428584.1 1041244 R 458234 CDS YP_001428585.1 156502520 5524112 1041849..1042703 1 NC_009749.1 this fusion consists of methionine sulfoxide B reductase at the N-terminus and A at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion protein of these enzymes with thioredoxin provides protection against oxidative stress in Neisseria gonorrhoeae; bifunctional methionine sulfoxide reductase B/A protein 1042703 msrAB 5524112 msrAB Francisella tularensis subsp. holarctica FTNF002-00 bifunctional methionine sulfoxide reductase B/A protein YP_001428585.1 1041849 D 458234 CDS YP_001428588.1 156502523 5524116 complement(1044163..1045284) 1 NC_009749.1 DSBA-like thioredoxin domain-containing protein 1045284 5524116 FTA_1156 Francisella tularensis subsp. holarctica FTNF002-00 DSBA-like thioredoxin domain-containing protein YP_001428588.1 1044163 R 458234 CDS YP_001428589.1 156502524 5524117 complement(1045305..1045595) 1 NC_009749.1 lipoprotein 1045595 5524117 FTA_1157 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001428589.1 1045305 R 458234 CDS YP_001428592.2 169656615 5522614 complement(1046772..1047179) 1 NC_009749.1 putative iojap-like protein 1047179 5522614 FTA_1160 Francisella tularensis subsp. holarctica FTNF002-00 putative iojap-like protein YP_001428592.2 1046772 R 458234 CDS YP_001428593.1 156502528 5522615 1047210..1047545 1 NC_009749.1 hypothetical protein 1047545 5522615 FTA_1161 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428593.1 1047210 D 458234 CDS YP_001428598.1 156502533 5522619 1050056..1052653 1 NC_009749.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1052653 alaS 5522619 alaS Francisella tularensis subsp. holarctica FTNF002-00 alanyl-tRNA synthetase YP_001428598.1 1050056 D 458234 CDS YP_001428599.2 169656616 5522621 1052661..1054043 1 NC_009749.1 outer membrane efflux protein 1054043 5522621 FTA_1167 Francisella tularensis subsp. holarctica FTNF002-00 outer membrane efflux protein YP_001428599.2 1052661 D 458234 CDS YP_001428600.2 169656617 5522622 1054046..1055425 1 NC_009749.1 cytosol aminopeptidase 1055425 5522622 FTA_1168 Francisella tularensis subsp. holarctica FTNF002-00 cytosol aminopeptidase YP_001428600.2 1054046 D 458234 CDS YP_001428601.2 169656618 5522623 1055505..1056524 1 NC_009749.1 transaldolase B 1056524 tal 5522623 tal Francisella tularensis subsp. holarctica FTNF002-00 transaldolase B YP_001428601.2 1055505 D 458234 CDS YP_001428602.1 156502537 5522624 1056550..1057008 1 NC_009749.1 hypothetical protein 1057008 5522624 FTA_1170 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428602.1 1056550 D 458234 CDS YP_001428604.1 156502539 5522626 1057731..1058528 1 NC_009749.1 transposase ISFTu2 1058528 5522626 FTA_1172 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428604.1 1057731 D 458234 CDS YP_001428605.2 169656619 5522627 complement(1058579..1059256) 1 NC_009749.1 nicotinamide mononucleotide transport (NMT) family protein 1059256 5522627 FTA_1173 Francisella tularensis subsp. holarctica FTNF002-00 nicotinamide mononucleotide transport (NMT) family protein YP_001428605.2 1058579 R 458234 CDS YP_001428606.2 169656620 5522873 complement(1059253..1059771) 1 NC_009749.1 hypothetical protein 1059771 5522873 FTA_1174 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428606.2 1059253 R 458234 CDS YP_001428607.2 169656621 5522874 1060379..1061125 1 NC_009749.1 putative aminomethyl transferase/glycine cleavage T-protein 1061125 5522874 FTA_1175 Francisella tularensis subsp. holarctica FTNF002-00 putative aminomethyl transferase/glycine cleavage T-protein YP_001428607.2 1060379 D 458234 CDS YP_001428608.1 156502543 5522875 1061119..1063134 1 NC_009749.1 ATP-dependent DNA helicase 1063134 rep 5522875 rep Francisella tularensis subsp. holarctica FTNF002-00 ATP-dependent DNA helicase YP_001428608.1 1061119 D 458234 CDS YP_001428609.1 156502544 5522876 1063190..1064020 1 NC_009749.1 hypothetical protein 1064020 5522876 FTA_1177 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428609.1 1063190 D 458234 CDS YP_001428610.2 169656622 5522877 complement(1064151..1065149) 1 NC_009749.1 rhodanese-like domain-containing protein 1065149 5522877 FTA_1178 Francisella tularensis subsp. holarctica FTNF002-00 rhodanese-like domain-containing protein YP_001428610.2 1064151 R 458234 CDS YP_001428611.1 156502546 5522878 1065331..1066191 1 NC_009749.1 Required for efficient pilin antigenic variation; recombination associated protein 1066191 rdgC 5522878 rdgC Francisella tularensis subsp. holarctica FTNF002-00 recombination associated protein YP_001428611.1 1065331 D 458234 CDS YP_001428612.1 156502547 5522879 1066196..1066453 1 NC_009749.1 hypothetical protein 1066453 5522879 FTA_1180 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428612.1 1066196 D 458234 CDS YP_001428613.1 156502548 5522880 1067117..1067920 1 NC_009749.1 hypothetical protein 1067920 5522880 FTA_1181 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428613.1 1067117 D 458234 CDS YP_001428616.1 156502551 5522883 1068811..1069902 1 NC_009749.1 hypothetical protein 1069902 5522883 FTA_1184 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428616.1 1068811 D 458234 CDS YP_001428618.1 156502553 5522885 complement(1070393..1071667) 1 NC_009749.1 HipA domain-containing protein 1071667 5522885 FTA_1186 Francisella tularensis subsp. holarctica FTNF002-00 HipA domain-containing protein YP_001428618.1 1070393 R 458234 CDS YP_001428619.1 156502554 5522886 complement(1071652..1071879) 1 NC_009749.1 helix-turn-helix domain-containing protein 1071879 5522886 FTA_1187 Francisella tularensis subsp. holarctica FTNF002-00 helix-turn-helix domain-containing protein YP_001428619.1 1071652 R 458234 CDS YP_001428620.1 156502555 5522887 1072177..1072353 1 NC_009749.1 hypothetical protein 1072353 5522887 FTA_1188 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428620.1 1072177 D 458234 CDS YP_001715626.1 169656794 5983832 1072461..1072580 1 NC_009749.1 hypothetical protein 1072580 5983832 FTA_2150 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001715626.1 1072461 D 458234 CDS YP_001428621.2 169656623 5523244 complement(join(1072667..1073218,1073218..1073547)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1073547 5523244 FTA_1189 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001428621.2 1072667 R 458234 CDS YP_001428623.2 169656624 5523246 1073538..1073807 1 NC_009749.1 hypothetical protein 1073807 5523246 FTA_1191 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428623.2 1073538 D 458234 CDS YP_001428624.1 156502560 5523247 1073900..1074391 1 NC_009749.1 GNAT family acetyltransferase 1074391 5523247 FTA_1193 Francisella tularensis subsp. holarctica FTNF002-00 GNAT family acetyltransferase YP_001428624.1 1073900 D 458234 CDS YP_001428627.1 156502562 5523250 complement(1075649..1076437) 1 NC_009749.1 inositol monophosphatase family protein 1076437 5523250 FTA_1195 Francisella tularensis subsp. holarctica FTNF002-00 inositol monophosphatase family protein YP_001428627.1 1075649 R 458234 CDS YP_001428628.1 156502563 5523251 complement(1076524..1077576) 1 NC_009749.1 hypothetical protein 1077576 5523251 FTA_1196 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428628.1 1076524 R 458234 CDS YP_001428629.1 156502564 5523252 complement(1077666..1078874) 1 NC_009749.1 hypothetical protein 1078874 5523252 FTA_1197 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428629.1 1077666 R 458234 CDS YP_001428630.1 156502566 5523253 1078996..1079682 1 NC_009749.1 hypothetical protein 1079682 5523253 FTA_1199 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428630.1 1078996 D 458234 CDS YP_001428631.1 156502565 5523255 complement(1079672..1079986) 1 NC_009749.1 YCII-related domain-containing protein 1079986 5523255 FTA_1198 Francisella tularensis subsp. holarctica FTNF002-00 YCII-related domain-containing protein YP_001428631.1 1079672 R 458234 CDS YP_001428632.1 156502567 5523254 complement(1080037..1081296) 1 NC_009749.1 beta-ketoacyl-acyl carrier protein synthase II 1081296 5523254 FTA_1200 Francisella tularensis subsp. holarctica FTNF002-00 beta-ketoacyl-acyl carrier protein synthase II YP_001428632.1 1080037 R 458234 CDS YP_001428633.2 169656625 5523256 complement(1081376..1081714) 1 NC_009749.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1081714 acpP 5523256 acpP Francisella tularensis subsp. holarctica FTNF002-00 acyl carrier protein YP_001428633.2 1081376 R 458234 CDS YP_001428634.1 156502569 5523257 complement(1081757..1082500) 1 NC_009749.1 3-oxoacyl-(acyl-carrier-protein) reductase 1082500 fabG 5523257 fabG Francisella tularensis subsp. holarctica FTNF002-00 3-oxoacyl-(acyl-carrier-protein) reductase YP_001428634.1 1081757 R 458234 CDS YP_001428635.1 156502570 5523258 complement(1082514..1083434) 1 NC_009749.1 malonyl CoA-acyl carrier protein transacylase 1083434 fabD 5523258 fabD Francisella tularensis subsp. holarctica FTNF002-00 malonyl CoA-acyl carrier protein transacylase YP_001428635.1 1082514 R 458234 CDS YP_001428636.1 156502571 5523058 complement(1083482..1084453) 1 NC_009749.1 3-oxoacyl-(acyl-carrier-protein) synthase III 1084453 5523058 FTA_1204 Francisella tularensis subsp. holarctica FTNF002-00 3-oxoacyl-(acyl-carrier-protein) synthase III YP_001428636.1 1083482 R 458234 CDS YP_001428637.1 156502572 5523059 complement(1084550..1085596) 1 NC_009749.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 1085596 plsX 5523059 plsX Francisella tularensis subsp. holarctica FTNF002-00 putative glycerol-3-phosphate acyltransferase PlsX YP_001428637.1 1084550 R 458234 CDS YP_001428638.1 156502573 5523060 complement(1085695..1085877) 1 NC_009749.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1085877 rpmF 5523060 rpmF Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L32 YP_001428638.1 1085695 R 458234 CDS YP_001428639.1 156502574 5523061 complement(1085921..1086424) 1 NC_009749.1 hypothetical protein 1086424 5523061 FTA_1207 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428639.1 1085921 R 458234 CDS YP_001428640.1 156502575 5523062 1086563..1088554 1 NC_009749.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1088554 tkt 5523062 tkt Francisella tularensis subsp. holarctica FTNF002-00 transketolase YP_001428640.1 1086563 D 458234 CDS YP_001428641.2 169656626 5523063 1088535..1089593 1 NC_009749.1 glyceraldehyde-3-phosphate dehydrogenase, type I 1089593 5523063 FTA_1209 Francisella tularensis subsp. holarctica FTNF002-00 glyceraldehyde-3-phosphate dehydrogenase, type I YP_001428641.2 1088535 D 458234 CDS YP_001428642.1 156502577 5523064 1089612..1090790 1 NC_009749.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1090790 pgk 5523064 pgk Francisella tularensis subsp. holarctica FTNF002-00 phosphoglycerate kinase YP_001428642.1 1089612 D 458234 CDS YP_001428643.1 156502578 5523065 1090806..1092242 1 NC_009749.1 pyruvate kinase 1092242 5523065 FTA_1211 Francisella tularensis subsp. holarctica FTNF002-00 pyruvate kinase YP_001428643.1 1090806 D 458234 CDS YP_001428644.1 156502579 5523066 1092261..1093325 1 NC_009749.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 1093325 fba 5523066 fba Francisella tularensis subsp. holarctica FTNF002-00 fructose-1,6-bisphosphate aldolase YP_001428644.1 1092261 D 458234 CDS YP_001428647.2 169656627 5523069 join(1095353..1095682,1095682..1096233) 1 NC_009749.1 programmed ribisomal frameshift; transposase ISFtu1 1096233 5523069 FTA_1215 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001428647.2 1095353 D 458234 CDS YP_001428649.1 156502584 5523071 complement(1096234..1097106) 1 NC_009749.1 hypothetical protein 1097106 5523071 FTA_1217 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428649.1 1096234 R 458234 CDS YP_001428652.2 169656628 5523130 1097858..1098448 1 NC_009749.1 Several genes in Francisella necessary for replication in macrophages and for virulence including iglA, iglC, and iglD and pathogenicity determinant protein genes pdpD and pdpA, are regulated by MglA. PMID:15375123, PMID:17000729; intracellular growth locus AII 1098448 iglAII 5523130 iglAII Francisella tularensis subsp. holarctica FTNF002-00 intracellular growth locus AII YP_001428652.2 1097858 D 458234 CDS YP_001428653.2 169656629 5523131 1098438..1099982 1 NC_009749.1 intracellular growth locus BII 1099982 iglB 5523131 iglB Francisella tularensis subsp. holarctica FTNF002-00 intracellular growth locus BII YP_001428653.2 1098438 D 458234 CDS YP_001428654.1 156502589 5523132 1099993..1100628 1 NC_009749.1 intracellular growth locus CII 1100628 iglCII 5523132 iglCII Francisella tularensis subsp. holarctica FTNF002-00 intracellular growth locus CII YP_001428654.1 1099993 D 458234 CDS YP_001428655.2 169656630 5523133 1100640..1101845 1 NC_009749.1 Part of Francisella pathogenicity island. PMID: 15375123; intracellular growth locus DII 1101845 iglDII 5523133 iglDII Francisella tularensis subsp. holarctica FTNF002-00 intracellular growth locus DII YP_001428655.2 1100640 D 458234 CDS YP_001428657.1 156502592 5523135 complement(1102445..1106431) 1 NC_009749.1 Several Francisella pathogenicity island (FPI) genes, including iglC, iglD, and pdpA to pdpD, regulated by MglA are necessary for replication in macrophages and for virulence. PMID:15375123, PMID:17000729; pathogenicity determinant protein PdpC 1106431 pdpCII 5523135 pdpCII Francisella tularensis subsp. holarctica FTNF002-00 pathogenicity determinant protein PdpC YP_001428657.1 1102445 R 458234 CDS YP_001428658.1 156502593 5523136 complement(1106471..1107244) 1 NC_009749.1 hypothetical protein 1107244 5523136 FTA_1226 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428658.1 1106471 R 458234 CDS YP_001428660.1 156502595 5523138 complement(1108383..1109006) 1 NC_009749.1 hypothetical protein 1109006 5523138 FTA_1228 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428660.1 1108383 R 458234 CDS YP_001428661.1 156502596 5523139 complement(1109019..1110449) 1 NC_009749.1 hypothetical protein 1110449 5523139 FTA_1229 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428661.1 1109019 R 458234 CDS YP_001428662.2 169656631 5523140 complement(1110462..1110983) 1 NC_009749.1 hypothetical protein 1110983 5523140 FTA_1230 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428662.2 1110462 R 458234 CDS YP_001428665.1 156502600 5523143 complement(1113227..1113604) 1 NC_009749.1 putative lipoprotein 1113604 5523143 FTA_1233 Francisella tularensis subsp. holarctica FTNF002-00 putative lipoprotein YP_001428665.1 1113227 R 458234 CDS YP_001428666.1 156502601 5522931 complement(1113594..1116875) 1 NC_009749.1 Several Francisella pathogenicity island (FPI) genes, including iglC, iglD, and pdpA to pdpD, regulated by MglA are necessary for replication in macrophages and for virulence. PMID:15375123, PMID:17000729; pathogenicity deteminant protein PdpB 1116875 pdpBII 5522931 pdpBII Francisella tularensis subsp. holarctica FTNF002-00 pathogenicity deteminant protein PdpB YP_001428666.1 1113594 R 458234 CDS YP_001428667.1 156502602 5522932 complement(1116880..1119342) 1 NC_009749.1 Several Francisella pathogenicity island (FPI) genes, including iglC, iglD, and pdpA to pdpD, regulated by MglA are necessary for replication in macrophages and for virulence. PMID:15375123, PMID:17000729; pathogenicity deteminant protein PdpA 1119342 pdpAII 5522932 pdpAII Francisella tularensis subsp. holarctica FTNF002-00 pathogenicity deteminant protein PdpA YP_001428667.1 1116880 R 458234 CDS YP_001428668.1 156502603 5524150 complement(1124922..1125506) 1 NC_009749.1 hypothetical protein 1125506 5524150 FTA_1237 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428668.1 1124922 R 458234 CDS YP_001428669.1 156502604 5522934 complement(1125753..1126676) 1 NC_009749.1 pyridoxal-phosphate dependent protein 1126676 5522934 FTA_1238 Francisella tularensis subsp. holarctica FTNF002-00 pyridoxal-phosphate dependent protein YP_001428669.1 1125753 R 458234 CDS YP_001428670.1 156502605 5522935 complement(1127103..1127948) 1 NC_009749.1 probable truncation compared to homologs; choloylglycine hydrolase family lipoprotein 1127948 5522935 FTA_1239 Francisella tularensis subsp. holarctica FTNF002-00 choloylglycine hydrolase family lipoprotein YP_001428670.1 1127103 R 458234 CDS YP_001428673.1 156502608 5522938 1129004..1129198 1 NC_009749.1 hypothetical protein 1129198 5522938 FTA_1242 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428673.1 1129004 D 458234 CDS YP_001428674.1 156502609 5522939 complement(1129208..1130560) 1 NC_009749.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 1130560 trmE 5522939 trmE Francisella tularensis subsp. holarctica FTNF002-00 tRNA modification GTPase TrmE YP_001428674.1 1129208 R 458234 CDS YP_001428675.1 156502610 5522940 complement(1130566..1130811) 1 NC_009749.1 hypothetical protein 1130811 5522940 FTA_1244 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428675.1 1130566 R 458234 CDS YP_001428676.1 156502611 5522941 1130930..1131226 1 NC_009749.1 ribosomal subunit interface protein yfiA/sigma 54 modulation protein 1131226 5522941 FTA_1245 Francisella tularensis subsp. holarctica FTNF002-00 ribosomal subunit interface protein yfiA/sigma 54 modulation protein YP_001428676.1 1130930 D 458234 CDS YP_001428677.1 156502612 5522942 1131263..1131718 1 NC_009749.1 PEP-dependent sugar PTS system family protein 1131718 5522942 FTA_1246 Francisella tularensis subsp. holarctica FTNF002-00 PEP-dependent sugar PTS system family protein YP_001428677.1 1131263 D 458234 CDS YP_001428678.1 156502613 5522943 1131711..1132454 1 NC_009749.1 RNA methyltransferase 1132454 5522943 FTA_1247 Francisella tularensis subsp. holarctica FTNF002-00 RNA methyltransferase YP_001428678.1 1131711 D 458234 CDS YP_001428679.1 156502614 5522944 1132456..1133019 1 NC_009749.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1133019 rnhB 5522944 rnhB Francisella tularensis subsp. holarctica FTNF002-00 ribonuclease HII YP_001428679.1 1132456 D 458234 CDS YP_001428680.1 156502616 5522945 1133012..1134283 1 NC_009749.1 sodium-solute symporter family protein 1134283 5522945 FTA_1250 Francisella tularensis subsp. holarctica FTNF002-00 sodium-solute symporter family protein YP_001428680.1 1133012 D 458234 CDS YP_001428681.1 156502615 5522947 complement(1134280..1134687) 1 NC_009749.1 inferred from sequence similarity with MglB protein from F. novicida and function derived from mutation phenotype. PMID: 9701818; ClpXP protease specificity-enhancing factor 1134687 mglB 5522947 mglB Francisella tularensis subsp. holarctica FTNF002-00 ClpXP protease specificity-enhancing factor YP_001428681.1 1134280 R 458234 CDS YP_001428682.2 169656632 5522946 complement(1134689..1135306) 1 NC_009749.1 inferred from sequence similarity with MglB protein from F. novicida and function derived from mutation phenotype. PMID: 9701818; macrophage growth locus subunit A 1135306 mglA 5522946 mglA Francisella tularensis subsp. holarctica FTNF002-00 macrophage growth locus subunit A YP_001428682.2 1134689 R 458234 CDS YP_001428683.2 169656633 5522948 complement(1135366..1135764) 1 NC_009749.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 1135764 rpsI 5522948 rpsI Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S9 YP_001428683.2 1135366 R 458234 CDS YP_001428684.1 156502619 5522949 complement(1135771..1136199) 1 NC_009749.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 1136199 rplM 5522949 rplM Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L13 YP_001428684.1 1135771 R 458234 CDS YP_001428685.1 156502620 5522950 complement(1136338..1137522) 1 NC_009749.1 hypothetical protein 1137522 5522950 FTA_1254 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428685.1 1136338 R 458234 CDS YP_001428686.1 156502621 5522951 complement(1137515..1138666) 1 NC_009749.1 membrane-bound lytic murein transglycosylase A 1138666 5522951 FTA_1255 Francisella tularensis subsp. holarctica FTNF002-00 membrane-bound lytic murein transglycosylase A YP_001428686.1 1137515 R 458234 CDS YP_001428687.1 156502622 5522952 1138770..1139357 1 NC_009749.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 1139357 grpE 5522952 grpE Francisella tularensis subsp. holarctica FTNF002-00 heat shock protein GrpE YP_001428687.1 1138770 D 458234 CDS YP_001428688.1 156502623 5522953 1139458..1141386 1 NC_009749.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 1141386 dnaK 5522953 dnaK Francisella tularensis subsp. holarctica FTNF002-00 molecular chaperone DnaK YP_001428688.1 1139458 D 458234 CDS YP_001428689.2 169656634 5522954 1141412..1142590 1 NC_009749.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 1142590 dnaJ 5522954 dnaJ Francisella tularensis subsp. holarctica FTNF002-00 chaperone protein DnaJ YP_001428689.2 1141412 D 458234 CDS YP_001428690.1 156502625 5522955 complement(1142604..1143392) 1 NC_009749.1 N-terminal truncation compared to Schu4 and WY96-3418; LysR family transcriptional regulator 1143392 5522955 FTA_1259 Francisella tularensis subsp. holarctica FTNF002-00 LysR family transcriptional regulator YP_001428690.1 1142604 R 458234 CDS YP_001428692.2 169656635 5522957 join(1143757..1144086,1144086..1144637) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1144637 5522957 FTA_1261 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001428692.2 1143757 D 458234 CDS YP_001428696.1 156502631 5523405 1145606..1146619 1 NC_009749.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1146619 pheS 5523405 pheS Francisella tularensis subsp. holarctica FTNF002-00 phenylalanyl-tRNA synthetase subunit alpha YP_001428696.1 1145606 D 458234 CDS YP_001428697.1 156502632 5523406 1146640..1149012 1 NC_009749.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1149012 pheT 5523406 pheT Francisella tularensis subsp. holarctica FTNF002-00 phenylalanyl-tRNA synthetase subunit beta YP_001428697.1 1146640 D 458234 CDS YP_001428698.2 169656636 5523407 complement(1149055..1149486) 1 NC_009749.1 putative Fe2+/Zn2+ uptake regulation protein 1149486 5523407 FTA_1267 Francisella tularensis subsp. holarctica FTNF002-00 putative Fe2+/Zn2+ uptake regulation protein YP_001428698.2 1149055 R 458234 CDS YP_001428699.1 156502634 5523408 1149628..1150845 1 NC_009749.1 cobalamin synthesis, cobW/P47K family protein 1150845 5523408 FTA_1268 Francisella tularensis subsp. holarctica FTNF002-00 cobalamin synthesis, cobW/P47K family protein YP_001428699.1 1149628 D 458234 CDS YP_001428700.1 156502635 5523409 1150848..1151594 1 NC_009749.1 zinc/iron ABC transporter permease 1151594 5523409 FTA_1269 Francisella tularensis subsp. holarctica FTNF002-00 zinc/iron ABC transporter permease YP_001428700.1 1150848 D 458234 CDS YP_001428701.1 156502636 5523410 complement(1151616..1152605) 1 NC_009749.1 hypothetical protein 1152605 5523410 FTA_1270 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428701.1 1151616 R 458234 CDS YP_001428702.1 156502637 5523411 complement(1152773..1154203) 1 NC_009749.1 phospholipase D 1154203 5523411 FTA_1271 Francisella tularensis subsp. holarctica FTNF002-00 phospholipase D YP_001428702.1 1152773 R 458234 CDS YP_001428703.1 156502638 5523412 complement(1154295..1155722) 1 NC_009749.1 phospholipase D 1155722 5523412 FTA_1272 Francisella tularensis subsp. holarctica FTNF002-00 phospholipase D YP_001428703.1 1154295 R 458234 CDS YP_001428707.1 156502642 5523416 1157103..1157963 1 NC_009749.1 hypothetical protein 1157963 5523416 FTA_1276 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428707.1 1157103 D 458234 CDS YP_001428708.1 156502643 5523417 1157975..1158541 1 NC_009749.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1158541 dcd 5523417 dcd Francisella tularensis subsp. holarctica FTNF002-00 deoxycytidine triphosphate deaminase YP_001428708.1 1157975 D 458234 CDS YP_001428711.2 169656637 5523043 complement(1159799..1160374) 1 NC_009749.1 putative lipoprotein 1160374 5523043 FTA_1280 Francisella tularensis subsp. holarctica FTNF002-00 putative lipoprotein YP_001428711.2 1159799 R 458234 CDS YP_001428712.1 156502647 5523044 complement(1160382..1162823) 1 NC_009749.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 1162823 leuS 5523044 leuS Francisella tularensis subsp. holarctica FTNF002-00 leucyl-tRNA synthetase YP_001428712.1 1160382 R 458234 CDS YP_001428713.1 156502648 5523045 complement(1162931..1164826) 1 NC_009749.1 hypothetical protein 1164826 5523045 FTA_1282 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428713.1 1162931 R 458234 CDS YP_001428716.1 156502651 5523048 complement(1165626..1166036) 1 NC_009749.1 hypothetical protein 1166036 5523048 FTA_1285 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428716.1 1165626 R 458234 CDS YP_001428717.1 156502652 5523049 complement(1166038..1166622) 1 NC_009749.1 hypothetical protein 1166622 5523049 FTA_1286 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428717.1 1166038 R 458234 CDS YP_001428719.2 169656638 5523051 complement(1167256..1167627) 1 NC_009749.1 hypothetical protein 1167627 5523051 FTA_1288 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428719.2 1167256 R 458234 CDS YP_001428721.2 169656639 5523053 complement(1168281..1169405) 1 NC_009749.1 hypothetical protein 1169405 5523053 FTA_1290 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428721.2 1168281 R 458234 CDS YP_001428722.1 156502657 5523054 complement(1169737..1170978) 1 NC_009749.1 hypothetical protein 1170978 5523054 FTA_1291 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428722.1 1169737 R 458234 CDS YP_001428723.1 156502658 5523055 1171207..1172574 1 NC_009749.1 amino-acid permease 1172574 5523055 FTA_1292 Francisella tularensis subsp. holarctica FTNF002-00 amino-acid permease YP_001428723.1 1171207 D 458234 CDS YP_001428724.1 156502659 5523056 1172626..1173231 1 NC_009749.1 hypothetical protein 1173231 5523056 FTA_1293 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428724.1 1172626 D 458234 CDS YP_001428725.2 169656640 5523057 1173235..1173528 1 NC_009749.1 hypothetical protein 1173528 5523057 FTA_1295 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428725.2 1173235 D 458234 CDS YP_001428727.1 156502662 5524291 complement(1173927..1174253) 1 NC_009749.1 thioredoxin 1174253 trx2 5524291 trx2 Francisella tularensis subsp. holarctica FTNF002-00 thioredoxin YP_001428727.1 1173927 R 458234 CDS YP_001428728.1 156502663 5524293 complement(1174257..1174946) 1 NC_009749.1 putative lipoprotein 1174946 5524293 FTA_1297 Francisella tularensis subsp. holarctica FTNF002-00 putative lipoprotein YP_001428728.1 1174257 R 458234 CDS YP_001428731.2 169656641 5524296 complement(1175913..1177067) 1 NC_009749.1 sufB/SufD domain-containing protein 1177067 5524296 FTA_1300 Francisella tularensis subsp. holarctica FTNF002-00 sufB/SufD domain-containing protein YP_001428731.2 1175913 R 458234 CDS YP_001428732.1 156502667 5524297 complement(1177071..1177820) 1 NC_009749.1 FeS assembly ATPase SufC 1177820 sufC 5524297 sufC Francisella tularensis subsp. holarctica FTNF002-00 FeS assembly ATPase SufC YP_001428732.1 1177071 R 458234 CDS YP_001428733.1 156502668 5524298 complement(1177859..1179304) 1 NC_009749.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 1179304 sufB 5524298 sufB Francisella tularensis subsp. holarctica FTNF002-00 cysteine desulfurase activator complex subunit SufB YP_001428733.1 1177859 R 458234 CDS YP_001428734.1 156502669 5524299 complement(1179311..1179721) 1 NC_009749.1 rrf2 family transcriptional regulator 1179721 5524299 FTA_1303 Francisella tularensis subsp. holarctica FTNF002-00 rrf2 family transcriptional regulator YP_001428734.1 1179311 R 458234 CDS YP_001428735.1 156502670 5524300 1179874..1181247 1 NC_009749.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 1181247 trkA 5524300 trkA Francisella tularensis subsp. holarctica FTNF002-00 potassium transporter peripheral membrane protein YP_001428735.1 1179874 D 458234 CDS YP_001428736.1 156502671 5524301 1181306..1182727 1 NC_009749.1 amino acid antiporter 1182727 5524301 FTA_1305 Francisella tularensis subsp. holarctica FTNF002-00 amino acid antiporter YP_001428736.1 1181306 D 458234 CDS YP_001428739.2 169656642 5524304 complement(1183689..1183907) 1 NC_009749.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1183907 infA 5524304 infA Francisella tularensis subsp. holarctica FTNF002-00 translation initiation factor IF-1 YP_001428739.2 1183689 R 458234 CDS YP_001428740.1 156502675 5524305 1184067..1184906 1 NC_009749.1 hypothetical protein 1184906 5524305 FTA_1309 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428740.1 1184067 D 458234 CDS YP_001428741.1 156502676 5523689 1184903..1185169 1 NC_009749.1 hypothetical protein 1185169 5523689 FTA_1310 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428741.1 1184903 D 458234 CDS YP_001428742.1 156502677 5523690 1185250..1186626 1 NC_009749.1 signal recognition particle protein 1186626 ffh 5523690 ffh Francisella tularensis subsp. holarctica FTNF002-00 signal recognition particle protein YP_001428742.1 1185250 D 458234 CDS YP_001428743.1 156502678 5523691 1186658..1187770 1 NC_009749.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1187770 5523691 FTA_1312 Francisella tularensis subsp. holarctica FTNF002-00 phospho-2-dehydro-3-deoxyheptonate aldolase YP_001428743.1 1186658 D 458234 CDS YP_001428744.2 169656643 5523692 complement(join(1187958..1188509,1188509..1188838)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1188838 5523692 FTA_1313 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001428744.2 1187958 R 458234 CDS YP_001428747.1 156502682 5523695 complement(1189086..1189418) 1 NC_009749.1 hypothetical protein 1189418 5523695 FTA_1316 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428747.1 1189086 R 458234 CDS YP_001428748.1 156502683 5523696 1189702..1190490 1 NC_009749.1 exodeoxyribonuclease III 1190490 xthA 5523696 xthA Francisella tularensis subsp. holarctica FTNF002-00 exodeoxyribonuclease III YP_001428748.1 1189702 D 458234 CDS YP_001428749.1 156502684 5523697 1190511..1191218 1 NC_009749.1 short chain dehydrogenase 1191218 5523697 FTA_1318 Francisella tularensis subsp. holarctica FTNF002-00 short chain dehydrogenase YP_001428749.1 1190511 D 458234 CDS YP_001428750.1 156502685 5523698 1191221..1191724 1 NC_009749.1 hypothetical protein 1191724 5523698 FTA_1319 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428750.1 1191221 D 458234 CDS YP_001428751.1 156502686 5523699 1191724..1192443 1 NC_009749.1 hypothetical protein 1192443 5523699 FTA_1320 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428751.1 1191724 D 458234 CDS YP_001428752.1 156502687 5523700 1192481..1193842 1 NC_009749.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 1193842 gor 5523700 gor Francisella tularensis subsp. holarctica FTNF002-00 glutathione reductase YP_001428752.1 1192481 D 458234 CDS YP_001428753.1 156502688 5523701 1193853..1194173 1 NC_009749.1 hypothetical protein 1194173 5523701 FTA_1322 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428753.1 1193853 D 458234 CDS YP_001428754.1 156502689 5523702 1194390..1195082 1 NC_009749.1 transposase ISFTu2 1195082 5523702 FTA_1323 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428754.1 1194390 D 458234 CDS YP_001428755.1 156502691 5523703 1195169..1196710 1 NC_009749.1 proton-dependent oligopeptide transporter (POT) family protein 1196710 5523703 FTA_1325 Francisella tularensis subsp. holarctica FTNF002-00 proton-dependent oligopeptide transporter (POT) family protein YP_001428755.1 1195169 D 458234 CDS YP_001428756.1 156502690 5522544 complement(1196707..1198032) 1 NC_009749.1 DEAD/DEAH box helicase 1198032 5522544 FTA_1324 Francisella tularensis subsp. holarctica FTNF002-00 DEAD/DEAH box helicase YP_001428756.1 1196707 R 458234 CDS YP_001428757.2 169656644 5522543 1198159..1198779 1 NC_009749.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 1198779 folE 5522543 folE Francisella tularensis subsp. holarctica FTNF002-00 GTP cyclohydrolase I YP_001428757.2 1198159 D 458234 CDS YP_001428760.1 156502695 5522547 1199626..1200057 1 NC_009749.1 hypothetical protein 1200057 5522547 FTA_1329 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428760.1 1199626 D 458234 CDS YP_001428765.1 156502700 5522552 complement(1203401..1203955) 1 NC_009749.1 anthranilate synthase component II 1203955 5522552 FTA_1334 Francisella tularensis subsp. holarctica FTNF002-00 anthranilate synthase component II YP_001428765.1 1203401 R 458234 CDS YP_001428766.1 156502701 5522553 complement(1203957..1205720) 1 NC_009749.1 chorismate-binding domain-containing protein 1205720 5522553 FTA_1335 Francisella tularensis subsp. holarctica FTNF002-00 chorismate-binding domain-containing protein YP_001428766.1 1203957 R 458234 CDS YP_001428767.1 156502702 5522554 complement(1205713..1207095) 1 NC_009749.1 AMP-binding domain-containing protein 1207095 5522554 FTA_1336 Francisella tularensis subsp. holarctica FTNF002-00 AMP-binding domain-containing protein YP_001428767.1 1205713 R 458234 CDS YP_001428768.1 156502703 5522555 1207165..1207518 1 NC_009749.1 dihydroneopterin aldolase 1207518 folB 5522555 folB Francisella tularensis subsp. holarctica FTNF002-00 dihydroneopterin aldolase YP_001428768.1 1207165 D 458234 CDS YP_001428769.1 156502704 5522556 1207520..1208785 1 NC_009749.1 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 1208785 folK 5522556 folK Francisella tularensis subsp. holarctica FTNF002-00 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_001428769.1 1207520 D 458234 CDS YP_001428770.1 156502705 5522557 1208798..1209718 1 NC_009749.1 alpha/beta hydrolase fold protein 1209718 5522557 FTA_1339 Francisella tularensis subsp. holarctica FTNF002-00 alpha/beta hydrolase fold protein YP_001428770.1 1208798 D 458234 CDS YP_001428771.1 156502706 5523859 1209734..1210234 1 NC_009749.1 hypothetical protein 1210234 5523859 FTA_1340 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428771.1 1209734 D 458234 CDS YP_001428775.2 169656645 5523863 complement(1211396..1212727) 1 NC_009749.1 adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1212727 5523863 FTA_1344 Francisella tularensis subsp. holarctica FTNF002-00 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_001428775.2 1211396 R 458234 CDS YP_001428776.1 156502711 5523864 1212773..1213714 1 NC_009749.1 biotin synthase 1213714 bioB 5523864 bioB Francisella tularensis subsp. holarctica FTNF002-00 biotin synthase YP_001428776.1 1212773 D 458234 CDS YP_001428777.1 156502712 5523865 1213708..1214835 1 NC_009749.1 8-amino-7-oxononanoate synthase 1214835 5523865 FTA_1346 Francisella tularensis subsp. holarctica FTNF002-00 8-amino-7-oxononanoate synthase YP_001428777.1 1213708 D 458234 CDS YP_001428778.1 156502713 5523866 1214813..1215550 1 NC_009749.1 biotin synthesis protein BioC 1215550 5523866 FTA_1347 Francisella tularensis subsp. holarctica FTNF002-00 biotin synthesis protein BioC YP_001428778.1 1214813 D 458234 CDS YP_001428779.1 156502714 5523867 1215554..1216213 1 NC_009749.1 dethiobiotin synthetase 1216213 bioD 5523867 bioD Francisella tularensis subsp. holarctica FTNF002-00 dethiobiotin synthetase YP_001428779.1 1215554 D 458234 CDS YP_001428780.1 156502715 5523868 complement(1216321..1217136) 1 NC_009749.1 C-terminal truncation compred to F. tularensis tularensis spp.; biotin-(acetyl-CoA-carboxylase) ligase domain-containing protein 1217136 5523868 FTA_1349 Francisella tularensis subsp. holarctica FTNF002-00 biotin-(acetyl-CoA-carboxylase) ligase domain-containing protein YP_001428780.1 1216321 R 458234 CDS YP_001428781.1 156502716 5523869 complement(1217159..1218043) 1 NC_009749.1 ROK family protein 1218043 5523869 FTA_1350 Francisella tularensis subsp. holarctica FTNF002-00 ROK family protein YP_001428781.1 1217159 R 458234 CDS YP_001428782.1 156502717 5523870 complement(1218045..1219304) 1 NC_009749.1 major facilitator superfamily transporter 1219304 5523870 FTA_1351 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator superfamily transporter YP_001428782.1 1218045 R 458234 CDS YP_001428786.1 156502721 5523617 1221173..1222840 1 NC_009749.1 glycoside hydrolase family protein 1222840 5523617 FTA_1355 Francisella tularensis subsp. holarctica FTNF002-00 glycoside hydrolase family protein YP_001428786.1 1221173 D 458234 CDS YP_001428787.1 156502722 5523618 complement(1222861..1224156) 1 NC_009749.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 1224156 hemL 5523618 hemL Francisella tularensis subsp. holarctica FTNF002-00 glutamate-1-semialdehyde aminotransferase YP_001428787.1 1222861 R 458234 CDS YP_001428788.1 156502723 5523619 complement(1224146..1225120) 1 NC_009749.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 1225120 gshB 5523619 gshB Francisella tularensis subsp. holarctica FTNF002-00 glutathione synthetase YP_001428788.1 1224146 R 458234 CDS YP_001428789.1 156502724 5523620 complement(1225124..1226065) 1 NC_009749.1 methionyl-tRNA formyltransferase 1226065 fmt 5523620 fmt Francisella tularensis subsp. holarctica FTNF002-00 methionyl-tRNA formyltransferase YP_001428789.1 1225124 R 458234 CDS YP_001428790.2 169656646 5523621 complement(1226070..1226447) 1 NC_009749.1 hypothetical protein 1226447 5523621 FTA_1359 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428790.2 1226070 R 458234 CDS YP_001428791.1 156502726 5523622 complement(1226570..1228723) 1 NC_009749.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1228723 rlmL 5523622 rlmL Francisella tularensis subsp. holarctica FTNF002-00 23S rRNA m(2)G2445 methyltransferase YP_001428791.1 1226570 R 458234 CDS YP_001428792.1 156502727 5523623 complement(1228798..1229352) 1 NC_009749.1 fatty acid hydroxylase 1229352 5523623 FTA_1361 Francisella tularensis subsp. holarctica FTNF002-00 fatty acid hydroxylase YP_001428792.1 1228798 R 458234 CDS YP_001428793.1 156502728 5524217 1230074..1230196 1 NC_009749.1 hypothetical protein 1230196 5524217 FTA_1362 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428793.1 1230074 D 458234 CDS YP_001428794.2 169656647 5523625 complement(1230318..1230812) 1 NC_009749.1 hypothetical protein 1230812 5523625 FTA_1363 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428794.2 1230318 R 458234 CDS YP_001428795.2 169656648 5523626 complement(join(1230784..1231335,1231335..1231664)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1231664 5523626 FTA_1364 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001428795.2 1230784 R 458234 CDS YP_001428797.1 156502732 5523628 1231758..1232876 1 NC_009749.1 hypothetical protein 1232876 5523628 FTA_1366 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428797.1 1231758 D 458234 CDS YP_001428798.1 156502733 5523629 1232930..1233400 1 NC_009749.1 hypothetical protein 1233400 5523629 FTA_1367 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428798.1 1232930 D 458234 CDS YP_001428799.1 156502734 5523630 1233537..1234361 1 NC_009749.1 oxidoreductase, short-chain dehydrogenase family protein 1234361 5523630 FTA_1368 Francisella tularensis subsp. holarctica FTNF002-00 oxidoreductase, short-chain dehydrogenase family protein YP_001428799.1 1233537 D 458234 CDS YP_001428802.1 156502737 5524030 complement(1235968..1236840) 1 NC_009749.1 hypothetical protein 1236840 5524030 FTA_1371 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428802.1 1235968 R 458234 CDS YP_001428803.2 169656649 5524031 join(1237008..1237337,1237337..1237888) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1237888 5524031 FTA_1372 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001428803.2 1237008 D 458234 CDS YP_001428805.1 156502740 5524033 complement(1237916..1238365) 1 NC_009749.1 hypothetical protein 1238365 5524033 FTA_1374 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428805.1 1237916 R 458234 CDS YP_001428806.2 169656650 5524034 complement(1238374..1238769) 1 NC_009749.1 hypothetical protein 1238769 5524034 FTA_1375 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428806.2 1238374 R 458234 CDS YP_001428808.1 156502743 5524036 1239710..1240441 1 NC_009749.1 oxidoreductase FAD/NAD-binding subunit 1240441 5524036 FTA_1377 Francisella tularensis subsp. holarctica FTNF002-00 oxidoreductase FAD/NAD-binding subunit YP_001428808.1 1239710 D 458234 CDS YP_001428809.1 156502744 5524037 1240524..1240781 1 NC_009749.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1240781 rpmE 5524037 rpmE Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L31 YP_001428809.1 1240524 D 458234 CDS YP_001428810.1 156502745 5524038 complement(1240990..1242495) 1 NC_009749.1 glutamate--cysteine ligase 1242495 gshA 5524038 gshA Francisella tularensis subsp. holarctica FTNF002-00 glutamate--cysteine ligase YP_001428810.1 1240990 R 458234 CDS YP_001428811.1 156502746 5524039 complement(1242548..1244089) 1 NC_009749.1 integral membrane protein MviN 1244089 mviN 5524039 mviN Francisella tularensis subsp. holarctica FTNF002-00 integral membrane protein MviN YP_001428811.1 1242548 R 458234 CDS YP_001428812.1 156502747 5524040 complement(1244112..1245173) 1 NC_009749.1 hypothetical protein 1245173 5524040 FTA_1381 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428812.1 1244112 R 458234 CDS YP_001428813.1 156502748 5524041 complement(1245256..1245666) 1 NC_009749.1 hypothetical protein 1245666 5524041 FTA_1382 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428813.1 1245256 R 458234 CDS YP_001428814.2 169656651 5524042 complement(1245644..1246825) 1 NC_009749.1 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase family protein 1246825 5524042 FTA_1383 Francisella tularensis subsp. holarctica FTNF002-00 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase family protein YP_001428814.2 1245644 R 458234 CDS YP_001428815.2 169656652 5524043 complement(1246840..1247748) 1 NC_009749.1 acetyl-CoA carboxylase, carboxyltransferase subunit beta 1247748 accD 5524043 accD Francisella tularensis subsp. holarctica FTNF002-00 acetyl-CoA carboxylase, carboxyltransferase subunit beta YP_001428815.2 1246840 R 458234 CDS YP_001428816.1 156502751 5524134 complement(1247784..1248206) 1 NC_009749.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1248206 ndk 5524134 ndk Francisella tularensis subsp. holarctica FTNF002-00 nucleoside diphosphate kinase YP_001428816.1 1247784 R 458234 CDS YP_001428817.1 156502752 5524135 complement(1248279..1249919) 1 NC_009749.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1249919 pyrG 5524135 pyrG Francisella tularensis subsp. holarctica FTNF002-00 CTP synthetase YP_001428817.1 1248279 R 458234 CDS YP_001428820.2 169656653 5524138 complement(1251743..1252675) 1 NC_009749.1 hypothetical protein 1252675 5524138 FTA_1389 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428820.2 1251743 R 458234 CDS YP_001428821.2 169656654 5524139 complement(1252697..1253131) 1 NC_009749.1 hypothetical protein 1253131 5524139 FTA_1390 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428821.2 1252697 R 458234 CDS YP_001428822.2 169656655 5524140 join(1253122..1253451,1253451..1254002) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1254002 5524140 FTA_1391 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001428822.2 1253122 D 458234 CDS YP_001428824.2 169656656 5524142 complement(1254198..1255193) 1 NC_009749.1 hypothetical protein 1255193 5524142 FTA_1393 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428824.2 1254198 R 458234 CDS YP_001428826.2 169656657 5524144 complement(1256448..1257059) 1 NC_009749.1 CRISPR-associated protein Cas4 1257059 5524144 FTA_1395 Francisella tularensis subsp. holarctica FTNF002-00 CRISPR-associated protein Cas4 YP_001428826.2 1256448 R 458234 CDS YP_001428827.1 156502762 5524145 complement(1257007..1257300) 1 NC_009749.1 hypothetical protein 1257300 5524145 FTA_1396 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428827.1 1257007 R 458234 CDS YP_001428834.2 169656658 5523232 complement(1263985..1265166) 1 NC_009749.1 OmpA (outer membrane protein A) family protein 1265166 5523232 FTA_1403 Francisella tularensis subsp. holarctica FTNF002-00 OmpA (outer membrane protein A) family protein YP_001428834.2 1263985 R 458234 CDS YP_001428835.1 156502770 5523233 complement(1265273..1265518) 1 NC_009749.1 4Fe-4S ferredoxin 1265518 5523233 FTA_1404 Francisella tularensis subsp. holarctica FTNF002-00 4Fe-4S ferredoxin YP_001428835.1 1265273 R 458234 CDS YP_001428836.1 156502771 5523234 complement(1265523..1266011) 1 NC_009749.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1266011 coaD 5523234 coaD Francisella tularensis subsp. holarctica FTNF002-00 phosphopantetheine adenylyltransferase YP_001428836.1 1265523 R 458234 CDS YP_001428837.1 156502772 5523235 complement(1266023..1266574) 1 NC_009749.1 hypothetical protein 1266574 5523235 FTA_1406 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428837.1 1266023 R 458234 CDS YP_001428838.1 156502773 5523236 complement(1266588..1266944) 1 NC_009749.1 iron-sulfur cluster assembly accessory protein 1266944 5523236 FTA_1407 Francisella tularensis subsp. holarctica FTNF002-00 iron-sulfur cluster assembly accessory protein YP_001428838.1 1266588 R 458234 CDS YP_001428839.1 156502774 5523237 complement(1266965..1268188) 1 NC_009749.1 selenocysteine lyase 1268188 5523237 FTA_1408 Francisella tularensis subsp. holarctica FTNF002-00 selenocysteine lyase YP_001428839.1 1266965 R 458234 CDS YP_001428840.1 156502775 5523238 complement(1268291..1269664) 1 NC_009749.1 L-serine ammonia-lyase 1269664 5523238 FTA_1409 Francisella tularensis subsp. holarctica FTNF002-00 L-serine ammonia-lyase YP_001428840.1 1268291 R 458234 CDS YP_001428841.1 156502776 5523239 complement(1269720..1270388) 1 NC_009749.1 hypothetical protein 1270388 5523239 FTA_1410 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428841.1 1269720 R 458234 CDS YP_001428842.1 156502777 5523240 complement(1270414..1271256) 1 NC_009749.1 prephenate dehydratase 1271256 pheA 5523240 pheA Francisella tularensis subsp. holarctica FTNF002-00 prephenate dehydratase YP_001428842.1 1270414 R 458234 CDS YP_001428845.2 169656659 5523243 complement(1273032..1274129) 1 NC_009749.1 alanine racemase 1274129 alr 5523243 alr Francisella tularensis subsp. holarctica FTNF002-00 alanine racemase YP_001428845.2 1273032 R 458234 CDS YP_001428848.2 169656660 5524241 complement(1275755..1276462) 1 NC_009749.1 hypothetical protein 1276462 5524241 FTA_1417 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428848.2 1275755 R 458234 CDS YP_001428849.1 156502784 5524242 complement(1276474..1276872) 1 NC_009749.1 hypothetical protein 1276872 5524242 FTA_1418 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428849.1 1276474 R 458234 CDS YP_001428851.2 169656661 5524244 1276952..1277974 1 NC_009749.1 hypothetical protein 1277974 5524244 FTA_1421 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428851.2 1276952 D 458234 CDS YP_001428850.1 156502785 5524243 complement(1277023..1277166) 1 NC_009749.1 hypothetical protein 1277166 5524243 FTA_1419 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428850.1 1277023 R 458234 CDS YP_001428857.1 156502792 5524250 1281333..1282172 1 NC_009749.1 transposase ISFTu2 1282172 5524250 FTA_1426 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428857.1 1281333 D 458234 CDS YP_001428859.1 156502794 5524252 complement(1282931..1285015) 1 NC_009749.1 glycyl-tRNA synthetase subunit beta 1285015 glyS 5524252 glyS Francisella tularensis subsp. holarctica FTNF002-00 glycyl-tRNA synthetase subunit beta YP_001428859.1 1282931 R 458234 CDS YP_001428860.1 156502795 5524253 1285208..1285882 1 NC_009749.1 TatD hydrolase family protein 1285882 5524253 FTA_1429 Francisella tularensis subsp. holarctica FTNF002-00 TatD hydrolase family protein YP_001428860.1 1285208 D 458234 CDS YP_001428861.1 156502796 5524276 1285886..1286935 1 NC_009749.1 DNA replication and repair protein RecF 1286935 5524276 FTA_1430 Francisella tularensis subsp. holarctica FTNF002-00 DNA replication and repair protein RecF YP_001428861.1 1285886 D 458234 CDS YP_001428862.1 156502797 5524277 1286957..1287250 1 NC_009749.1 hypothetical protein 1287250 5524277 FTA_1431 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428862.1 1286957 D 458234 CDS YP_001428863.1 156502798 5524278 1287335..1287541 1 NC_009749.1 putative lipoprotein 1287541 5524278 FTA_1432 Francisella tularensis subsp. holarctica FTNF002-00 putative lipoprotein YP_001428863.1 1287335 D 458234 CDS YP_001428864.1 156502799 5524279 complement(1287544..1288461) 1 NC_009749.1 hypothetical protein 1288461 5524279 FTA_1433 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428864.1 1287544 R 458234 CDS YP_001428865.1 156502800 5524280 complement(1288473..1289345) 1 NC_009749.1 Missing N-terminal residues; acyl-co A synthetase fragment 1289345 5524280 FTA_1434 Francisella tularensis subsp. holarctica FTNF002-00 acyl-co A synthetase fragment YP_001428865.1 1288473 R 458234 CDS YP_001428866.1 156502801 5524281 complement(1289934..1290797) 1 NC_009749.1 UTP--glucose-1-phosphate uridylyltransferase 1290797 galU 5524281 galU Francisella tularensis subsp. holarctica FTNF002-00 UTP--glucose-1-phosphate uridylyltransferase YP_001428866.1 1289934 R 458234 CDS YP_001428867.1 156502802 5524282 complement(1290814..1291953) 1 NC_009749.1 cation-efflux family protein 1291953 5524282 FTA_1436 Francisella tularensis subsp. holarctica FTNF002-00 cation-efflux family protein YP_001428867.1 1290814 R 458234 CDS YP_001428871.1 156502806 5524286 complement(1293481..1293681) 1 NC_009749.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1293681 rpsU 5524286 rpsU Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S21 YP_001428871.1 1293481 R 458234 CDS YP_001428872.1 156502807 5524287 1294058..1294255 1 NC_009749.1 hypothetical protein 1294255 5524287 FTA_1441 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428872.1 1294058 D 458234 CDS YP_001428873.1 156502808 5524288 1294454..1294657 1 NC_009749.1 cold-shock DNA-binding domain-containing protein 1294657 5524288 FTA_1442 Francisella tularensis subsp. holarctica FTNF002-00 cold-shock DNA-binding domain-containing protein YP_001428873.1 1294454 D 458234 CDS YP_001428874.1 156502809 5524289 complement(1294728..1295714) 1 NC_009749.1 hypothetical protein 1295714 5524289 FTA_1443 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428874.1 1294728 R 458234 CDS YP_001428875.1 156502810 5524290 1296236..1296919 1 NC_009749.1 missing N-terminal residues compared to other Francisella strains; hypothetical protein 1296919 5524290 FTA_1444 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428875.1 1296236 D 458234 CDS YP_001428876.1 156502811 5524044 complement(1296943..1297662) 1 NC_009749.1 putative transcriptional regulator, IclR family protein 1297662 5524044 FTA_1445 Francisella tularensis subsp. holarctica FTNF002-00 putative transcriptional regulator, IclR family protein YP_001428876.1 1296943 R 458234 CDS YP_001428881.2 169656662 5524049 complement(join(1300390..1300941,1300941..1301270)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1301270 5524049 FTA_1450 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001428881.2 1300390 R 458234 CDS YP_001428883.1 156502818 5524051 complement(1301646..1302461) 1 NC_009749.1 hypothetical protein 1302461 5524051 FTA_1452 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428883.1 1301646 R 458234 CDS YP_001428889.1 156502824 5524057 1308419..1308547 1 NC_009749.1 hypothetical protein 1308547 5524057 FTA_1458 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428889.1 1308419 D 458234 CDS YP_001428890.1 156502825 5524058 1308564..1308932 1 NC_009749.1 S4 domain-containing protein 1308932 5524058 FTA_1459 Francisella tularensis subsp. holarctica FTNF002-00 S4 domain-containing protein YP_001428890.1 1308564 D 458234 CDS YP_001428891.2 169656663 5522888 complement(1308967..1310460) 1 NC_009749.1 putative carbohydrate kinase/YjeF-like protein 1310460 5522888 FTA_1460 Francisella tularensis subsp. holarctica FTNF002-00 putative carbohydrate kinase/YjeF-like protein YP_001428891.2 1308967 R 458234 CDS YP_001428892.1 156502827 5522889 complement(1310489..1310668) 1 NC_009749.1 hypothetical protein 1310668 5522889 FTA_1461 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428892.1 1310489 R 458234 CDS YP_001428893.1 156502828 5522890 1310628..1310756 1 NC_009749.1 hypothetical protein 1310756 5522890 FTA_1462 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428893.1 1310628 D 458234 CDS YP_001428894.1 156502829 5522891 complement(1310767..1311414) 1 NC_009749.1 hypothetical protein 1311414 5522891 FTA_1463 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428894.1 1310767 R 458234 CDS YP_001428900.1 156502835 5522897 complement(1313704..1314174) 1 NC_009749.1 glutathione peroxidase 1314174 5522897 FTA_1469 Francisella tularensis subsp. holarctica FTNF002-00 glutathione peroxidase YP_001428900.1 1313704 R 458234 CDS YP_001428901.2 169656664 5522898 complement(1314203..1314550) 1 NC_009749.1 chorismate mutase 1314550 5522898 FTA_1470 Francisella tularensis subsp. holarctica FTNF002-00 chorismate mutase YP_001428901.2 1314203 R 458234 CDS YP_001428902.1 156502837 5522899 1314647..1315093 1 NC_009749.1 hypothetical protein 1315093 5522899 FTA_1471 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428902.1 1314647 D 458234 CDS YP_001428903.1 156502838 5522900 complement(1315268..1315951) 1 NC_009749.1 transposase ISFTu2 1315951 5522900 FTA_1472 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428903.1 1315268 R 458234 CDS YP_001428906.1 156502841 5523530 complement(1317183..1318670) 1 NC_009749.1 L-aspartate oxidase 1318670 nadB 5523530 nadB Francisella tularensis subsp. holarctica FTNF002-00 L-aspartate oxidase YP_001428906.1 1317183 R 458234 CDS YP_001428907.1 156502842 5523531 complement(1318673..1319536) 1 NC_009749.1 nicotinate-nucleotide pyrophosphorylase 1319536 nadC 5523531 nadC Francisella tularensis subsp. holarctica FTNF002-00 nicotinate-nucleotide pyrophosphorylase YP_001428907.1 1318673 R 458234 CDS YP_001428908.1 156502843 5523532 complement(1319545..1320570) 1 NC_009749.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 1320570 nadA 5523532 nadA Francisella tularensis subsp. holarctica FTNF002-00 quinolinate synthetase YP_001428908.1 1319545 R 458234 CDS YP_001428909.1 156502844 5523533 complement(1320591..1321163) 1 NC_009749.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1321163 gmk 5523533 gmk Francisella tularensis subsp. holarctica FTNF002-00 guanylate kinase YP_001428909.1 1320591 R 458234 CDS YP_001428910.1 156502845 5523534 complement(1321280..1322989) 1 NC_009749.1 DEAD/DEAH box helicase 1322989 5523534 FTA_1479 Francisella tularensis subsp. holarctica FTNF002-00 DEAD/DEAH box helicase YP_001428910.1 1321280 R 458234 CDS YP_001428911.1 156502846 5523535 complement(1323024..1323302) 1 NC_009749.1 peptidyl-prolyl cis-trans isomerase domain-containing protein 1323302 5523535 FTA_1480 Francisella tularensis subsp. holarctica FTNF002-00 peptidyl-prolyl cis-trans isomerase domain-containing protein YP_001428911.1 1323024 R 458234 CDS YP_001428912.1 156502847 5523536 complement(1323397..1324791) 1 NC_009749.1 major facilitator superfamily sugar transporter 1324791 5523536 FTA_1481 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator superfamily sugar transporter YP_001428912.1 1323397 R 458234 CDS YP_001428913.2 169656665 5523537 complement(1324823..1326178) 1 NC_009749.1 major facilitator superfamily sugar transporter 1326178 5523537 FTA_1482 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator superfamily sugar transporter YP_001428913.2 1324823 R 458234 CDS YP_001428914.1 156502849 5523538 1326294..1327319 1 NC_009749.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 1327319 galT 5523538 galT Francisella tularensis subsp. holarctica FTNF002-00 galactose-1-phosphate uridylyltransferase YP_001428914.1 1326294 D 458234 CDS YP_001428915.2 169656666 5523539 1327322..1328470 1 NC_009749.1 galactokinase 1328470 galK 5523539 galK Francisella tularensis subsp. holarctica FTNF002-00 galactokinase YP_001428915.2 1327322 D 458234 CDS YP_001428916.1 156502850 5523541 complement(1328467..1328862) 1 NC_009749.1 histidine triad domain-containing protein 1328862 5523541 FTA_1484 Francisella tularensis subsp. holarctica FTNF002-00 histidine triad domain-containing protein YP_001428916.1 1328467 R 458234 CDS YP_001428917.1 156502852 5523540 complement(1328855..1329607) 1 NC_009749.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1329607 kdsB 5523540 kdsB Francisella tularensis subsp. holarctica FTNF002-00 3-deoxy-manno-octulosonate cytidylyltransferase YP_001428917.1 1328855 R 458234 CDS YP_001428918.2 169656667 5523542 complement(1329600..1329848) 1 NC_009749.1 hypothetical protein 1329848 5523542 FTA_1487 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428918.2 1329600 R 458234 CDS YP_001428919.2 169656668 5523543 complement(join(1330417..1330968,1330968..1331297)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1331297 5523543 FTA_1488 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001428919.2 1330417 R 458234 CDS YP_001428921.1 156502856 5523287 complement(1331589..1332293) 1 NC_009749.1 hypothetical protein 1332293 5523287 FTA_1490 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428921.1 1331589 R 458234 CDS YP_001428922.1 156502857 5523288 complement(1332335..1332691) 1 NC_009749.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1332691 rplT 5523288 rplT Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L20 YP_001428922.1 1332335 R 458234 CDS YP_001428923.1 156502858 5523289 complement(1332727..1332924) 1 NC_009749.1 50S ribosomal protein L35 1332924 rpmI 5523289 rpmI Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L35 YP_001428923.1 1332727 R 458234 CDS YP_001428924.2 169656669 5523290 complement(1332967..1333488) 1 NC_009749.1 translation initiation factor IF-3 1333488 infC 5523290 infC Francisella tularensis subsp. holarctica FTNF002-00 translation initiation factor IF-3 YP_001428924.2 1332967 R 458234 CDS YP_001428925.1 156502860 5523291 complement(1333510..1335414) 1 NC_009749.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1335414 thrS 5523291 thrS Francisella tularensis subsp. holarctica FTNF002-00 threonyl-tRNA synthetase YP_001428925.1 1333510 R 458234 CDS YP_001428927.1 156502862 5523293 complement(1337721..1338017) 1 NC_009749.1 hypothetical protein 1338017 5523293 FTA_1496 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428927.1 1337721 R 458234 CDS YP_001428928.1 156502863 5523294 complement(1338007..1338387) 1 NC_009749.1 glycine cleavage system protein H 1338387 gcvH2 5523294 gcvH2 Francisella tularensis subsp. holarctica FTNF002-00 glycine cleavage system protein H YP_001428928.1 1338007 R 458234 CDS YP_001428929.1 156502864 5523295 1338491..1339606 1 NC_009749.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 1339606 murG 5523295 murG Francisella tularensis subsp. holarctica FTNF002-00 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_001428929.1 1338491 D 458234 CDS YP_001428930.1 156502865 5523296 1339616..1339954 1 NC_009749.1 hypothetical protein 1339954 5523296 FTA_1499 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428930.1 1339616 D 458234 CDS YP_001428931.1 156502866 5523297 1339954..1340556 1 NC_009749.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1340556 recR 5523297 recR Francisella tularensis subsp. holarctica FTNF002-00 recombination protein RecR YP_001428931.1 1339954 D 458234 CDS YP_001428932.2 169656670 5523298 complement(1340564..1342687) 1 NC_009749.1 RelA/SpoT family protein 1342687 5523298 FTA_1501 Francisella tularensis subsp. holarctica FTNF002-00 RelA/SpoT family protein YP_001428932.2 1340564 R 458234 CDS YP_001428933.2 169656671 5523299 complement(1342747..1343958) 1 NC_009749.1 hypothetical protein 1343958 5523299 FTA_1502 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428933.2 1342747 R 458234 CDS YP_001428934.1 156502869 5523300 complement(1343960..1344424) 1 NC_009749.1 capsule biosynthesis protein CapC 1344424 5523300 FTA_1503 Francisella tularensis subsp. holarctica FTNF002-00 capsule biosynthesis protein CapC YP_001428934.1 1343960 R 458234 CDS YP_001428935.2 169656672 5523301 complement(1344449..1345666) 1 NC_009749.1 hypothetical protein 1345666 5523301 FTA_1504 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428935.2 1344449 R 458234 CDS YP_001428936.1 156502871 5524434 complement(1345742..1346998) 1 NC_009749.1 major facilitator transporter 1346998 5524434 FTA_1505 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001428936.1 1345742 R 458234 CDS YP_001428937.1 156502872 5524223 complement(1347670..1348533) 1 NC_009749.1 asparaginase 1348533 5524223 FTA_1506 Francisella tularensis subsp. holarctica FTNF002-00 asparaginase YP_001428937.1 1347670 R 458234 CDS YP_001428938.2 169656673 5524436 complement(1348749..1349567) 1 NC_009749.1 cyanophycinase 1349567 5524436 FTA_1507 Francisella tularensis subsp. holarctica FTNF002-00 cyanophycinase YP_001428938.2 1348749 R 458234 CDS YP_001428939.1 156502874 5524437 1349770..1350876 1 NC_009749.1 pfkB family sugar kinase 1350876 5524437 FTA_1508 Francisella tularensis subsp. holarctica FTNF002-00 pfkB family sugar kinase YP_001428939.1 1349770 D 458234 CDS YP_001428940.1 156502875 5524438 complement(1351158..1351820) 1 NC_009749.1 HAD family hydrolase 1351820 5524438 FTA_1509 Francisella tularensis subsp. holarctica FTNF002-00 HAD family hydrolase YP_001428940.1 1351158 R 458234 CDS YP_001428941.1 156502876 5524439 complement(1351839..1352852) 1 NC_009749.1 glycosyl transferases group 1 family protein 1352852 5524439 FTA_1510 Francisella tularensis subsp. holarctica FTNF002-00 glycosyl transferases group 1 family protein YP_001428941.1 1351839 R 458234 CDS YP_001428942.1 156502877 5524440 complement(1352855..1353862) 1 NC_009749.1 glycosyl transferase group 2 family protein 1353862 5524440 FTA_1511 Francisella tularensis subsp. holarctica FTNF002-00 glycosyl transferase group 2 family protein YP_001428942.1 1352855 R 458234 CDS YP_001428943.1 156502878 5524441 complement(1353879..1354838) 1 NC_009749.1 glycosyl transferase group 2 family protein 1354838 5524441 FTA_1512 Francisella tularensis subsp. holarctica FTNF002-00 glycosyl transferase group 2 family protein YP_001428943.1 1353879 R 458234 CDS YP_001428944.2 169656674 5524442 complement(1354847..1355608) 1 NC_009749.1 hypothetical protein 1355608 5524442 FTA_1513 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428944.2 1354847 R 458234 CDS YP_001428945.2 169656675 5524443 complement(1355612..1356307) 1 NC_009749.1 hypothetical protein 1356307 5524443 FTA_1514 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428945.2 1355612 R 458234 CDS YP_001428946.1 156502881 5524444 complement(1356234..1357520) 1 NC_009749.1 HAD family hydrolase 1357520 5524444 FTA_1515 Francisella tularensis subsp. holarctica FTNF002-00 HAD family hydrolase YP_001428946.1 1356234 R 458234 CDS YP_001428947.1 156502882 5524445 complement(1357534..1359216) 1 NC_009749.1 ABC transporter ATP-binding protein 1359216 5524445 FTA_1516 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter ATP-binding protein YP_001428947.1 1357534 R 458234 CDS YP_001428948.1 156502883 5524446 complement(1359213..1360442) 1 NC_009749.1 glycosyl transferase family protein 1360442 5524446 FTA_1517 Francisella tularensis subsp. holarctica FTNF002-00 glycosyl transferase family protein YP_001428948.1 1359213 R 458234 CDS YP_001428949.1 156502884 5524447 complement(1360446..1361465) 1 NC_009749.1 UDP-glucose 4-epimerase 1361465 galE 5524447 galE Francisella tularensis subsp. holarctica FTNF002-00 UDP-glucose 4-epimerase YP_001428949.1 1360446 R 458234 CDS YP_001428950.2 169656676 5524448 complement(1361458..1362852) 1 NC_009749.1 sugar transferase 1362852 5524448 FTA_1519 Francisella tularensis subsp. holarctica FTNF002-00 sugar transferase YP_001428950.2 1361458 R 458234 CDS YP_001428951.1 156502886 5524621 complement(1362833..1363501) 1 NC_009749.1 D-ribulose-phosphate 3-epimerase 1363501 rpe 5524621 rpe Francisella tularensis subsp. holarctica FTNF002-00 D-ribulose-phosphate 3-epimerase YP_001428951.1 1362833 R 458234 CDS YP_001428952.2 169656677 5524622 1363626..1364609 1 NC_009749.1 sugar isomerase 1364609 5524622 FTA_1521 Francisella tularensis subsp. holarctica FTNF002-00 sugar isomerase YP_001428952.2 1363626 D 458234 CDS YP_001428953.2 169656678 5524623 complement(1364613..1365203) 1 NC_009749.1 hypothetical protein 1365203 5524623 FTA_1522 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428953.2 1364613 R 458234 CDS YP_001428956.2 169656679 5524626 complement(1365908..1366726) 1 NC_009749.1 hypothetical protein 1366726 5524626 FTA_1525 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428956.2 1365908 R 458234 CDS YP_001428957.1 156502892 5524627 complement(1366714..1367043) 1 NC_009749.1 hypothetical protein 1367043 5524627 FTA_1526 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428957.1 1366714 R 458234 CDS YP_001428959.1 156502894 5524629 1368295..1368996 1 NC_009749.1 transposase ISFTu2 1368996 5524629 FTA_1528 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428959.1 1368295 D 458234 CDS YP_001428960.1 156502895 5524630 complement(1369021..1369803) 1 NC_009749.1 hypothetical protein 1369803 5524630 FTA_1529 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428960.1 1369021 R 458234 CDS YP_001428961.1 156502896 5524631 1370089..1370802 1 NC_009749.1 hypothetical protein 1370802 5524631 FTA_1530 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428961.1 1370089 D 458234 CDS YP_001428962.2 169656680 5524632 1370792..1371061 1 NC_009749.1 hypothetical protein 1371061 5524632 FTA_1531 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428962.2 1370792 D 458234 CDS YP_001428963.1 156502898 5524633 1371518..1372357 1 NC_009749.1 transposase ISFTu2 1372357 5524633 FTA_1532 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428963.1 1371518 D 458234 CDS YP_001428964.2 169656681 5524634 complement(join(1372141..1372638,1372638..1372967)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1372967 5524634 FTA_1533 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001428964.2 1372141 R 458234 CDS YP_001428965.1 156502900 5524635 complement(1373045..1373419) 1 NC_009749.1 hypothetical protein 1373419 5524635 FTA_1534 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428965.1 1373045 R 458234 CDS YP_001428966.1 156502901 5524419 complement(1373486..1375324) 1 NC_009749.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1375324 uvrC 5524419 uvrC Francisella tularensis subsp. holarctica FTNF002-00 excinuclease ABC subunit C YP_001428966.1 1373486 R 458234 CDS YP_001428967.1 156502902 5524420 1375433..1376524 1 NC_009749.1 ribonuclease D 1376524 5524420 FTA_1536 Francisella tularensis subsp. holarctica FTNF002-00 ribonuclease D YP_001428967.1 1375433 D 458234 CDS YP_001428968.1 156502904 5524421 1376553..1377767 1 NC_009749.1 Bcr/CflA subfamily drug resistance transporter 1377767 5524421 FTA_1538 Francisella tularensis subsp. holarctica FTNF002-00 Bcr/CflA subfamily drug resistance transporter YP_001428968.1 1376553 D 458234 CDS YP_001428969.1 156502903 5524423 complement(1377764..1378141) 1 NC_009749.1 hypothetical protein 1378141 5524423 FTA_1537 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428969.1 1377764 R 458234 CDS YP_001428970.1 156502905 5524422 complement(1378528..1378782) 1 NC_009749.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1378782 rpmA 5524422 rpmA Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L27 YP_001428970.1 1378528 R 458234 CDS YP_001428971.1 156502906 5524424 complement(1378813..1379127) 1 NC_009749.1 50S ribosomal protein L21 1379127 rplU 5524424 rplU Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L21 YP_001428971.1 1378813 R 458234 CDS YP_001428976.1 156502911 5524429 complement(1381187..1383907) 1 NC_009749.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1383907 secA 5524429 secA Francisella tularensis subsp. holarctica FTNF002-00 preprotein translocase subunit SecA YP_001428976.1 1381187 R 458234 CDS YP_001428977.2 169656682 5524430 1384039..1385067 1 NC_009749.1 hypothetical protein 1385067 5524430 FTA_1546 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428977.2 1384039 D 458234 CDS YP_001428978.1 156502914 5524431 1385071..1385520 1 NC_009749.1 hypothetical protein 1385520 5524431 FTA_1548 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001428978.1 1385071 D 458234 CDS YP_001428979.1 156502913 5524433 complement(1385517..1386239) 1 NC_009749.1 purine nucleoside phosphorylase 1386239 deoD 5524433 deoD Francisella tularensis subsp. holarctica FTNF002-00 purine nucleoside phosphorylase YP_001428979.1 1385517 R 458234 CDS YP_001428980.2 169656683 5524432 complement(join(1386312..1386863,1386863..1387192)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1387192 5524432 FTA_1549 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001428980.2 1386312 R 458234 CDS YP_001428982.1 156502917 5523905 1387470..1388126 1 NC_009749.1 transposase ISFTu2 1388126 5523905 FTA_1551 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428982.1 1387470 D 458234 CDS YP_001428983.1 156502918 5523906 complement(1388220..1390166) 1 NC_009749.1 ATP-dependent metallopeptidase family protein 1390166 5523906 FTA_1552 Francisella tularensis subsp. holarctica FTNF002-00 ATP-dependent metallopeptidase family protein YP_001428983.1 1388220 R 458234 CDS YP_001428986.1 156502921 5523909 1391384..1392049 1 NC_009749.1 transposase ISFTu2 1392049 5523909 FTA_1555 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001428986.1 1391384 D 458234 CDS YP_001428989.1 156502924 5523912 complement(1392626..1395448) 1 NC_009749.1 excinuclease ABC subunit A 1395448 uvrA 5523912 uvrA Francisella tularensis subsp. holarctica FTNF002-00 excinuclease ABC subunit A YP_001428989.1 1392626 R 458234 CDS YP_001428990.1 156502925 5523913 complement(1395487..1395969) 1 NC_009749.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1395969 greA 5523913 greA Francisella tularensis subsp. holarctica FTNF002-00 transcription elongation factor GreA YP_001428990.1 1395487 R 458234 CDS YP_001428991.1 156502926 5523914 complement(1396003..1396587) 1 NC_009749.1 prepilin-type N-terminal cleavage/methylation domain-containing protein 1396587 5523914 FTA_1560 Francisella tularensis subsp. holarctica FTNF002-00 prepilin-type N-terminal cleavage/methylation domain-containing protein YP_001428991.1 1396003 R 458234 CDS YP_001428992.1 156502927 5523915 complement(1396588..1398210) 1 NC_009749.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1398210 pgi 5523915 pgi Francisella tularensis subsp. holarctica FTNF002-00 glucose-6-phosphate isomerase YP_001428992.1 1396588 R 458234 CDS YP_001428993.1 156502928 5523916 complement(1398197..1398850) 1 NC_009749.1 thiamine pyrophosphokinase 1398850 5523916 FTA_1562 Francisella tularensis subsp. holarctica FTNF002-00 thiamine pyrophosphokinase YP_001428993.1 1398197 R 458234 CDS YP_001428994.1 156502929 5523917 complement(1398916..1400376) 1 NC_009749.1 inosine-5'-monophosphate dehydrogenase 1400376 guaB 5523917 guaB Francisella tularensis subsp. holarctica FTNF002-00 inosine-5'-monophosphate dehydrogenase YP_001428994.1 1398916 R 458234 CDS YP_001428995.1 156502930 5523918 complement(1400477..1401916) 1 NC_009749.1 cytosol aminopeptidase 1401916 5523918 FTA_1564 Francisella tularensis subsp. holarctica FTNF002-00 cytosol aminopeptidase YP_001428995.1 1400477 R 458234 CDS YP_001428996.1 156502931 5523157 1402082..1403164 1 NC_009749.1 putative permease, YjgP/YjgQ family protein 1403164 5523157 FTA_1565 Francisella tularensis subsp. holarctica FTNF002-00 putative permease, YjgP/YjgQ family protein YP_001428996.1 1402082 D 458234 CDS YP_001428997.2 169656684 5523158 1403164..1404225 1 NC_009749.1 putative permease YjgP/YjgQ family protein 1404225 5523158 FTA_1566 Francisella tularensis subsp. holarctica FTNF002-00 putative permease YjgP/YjgQ family protein YP_001428997.2 1403164 D 458234 CDS YP_001428998.1 156502933 5523159 1404233..1405486 1 NC_009749.1 peptidase M16 family protein 1405486 5523159 FTA_1567 Francisella tularensis subsp. holarctica FTNF002-00 peptidase M16 family protein YP_001428998.1 1404233 D 458234 CDS YP_001428999.2 169656685 5523160 1405493..1406716 1 NC_009749.1 peptidase M16 family protein 1406716 5523160 FTA_1568 Francisella tularensis subsp. holarctica FTNF002-00 peptidase M16 family protein YP_001428999.2 1405493 D 458234 CDS YP_001429000.2 169656686 5523161 1406717..1407295 1 NC_009749.1 methyltransferase family protein 1407295 5523161 FTA_1569 Francisella tularensis subsp. holarctica FTNF002-00 methyltransferase family protein YP_001429000.2 1406717 D 458234 CDS YP_001429001.1 156502936 5523162 1407329..1407979 1 NC_009749.1 hypothetical protein 1407979 5523162 FTA_1570 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429001.1 1407329 D 458234 CDS YP_001429002.1 156502937 5523163 complement(1408032..1408643) 1 NC_009749.1 tRNA-(ms(2)io(6)a)-hydroxylase 1408643 5523163 FTA_1571 Francisella tularensis subsp. holarctica FTNF002-00 tRNA-(ms(2)io(6)a)-hydroxylase YP_001429002.1 1408032 R 458234 CDS YP_001429003.1 156502938 5523164 1408759..1409562 1 NC_009749.1 uridine phosphorylase 1409562 5523164 FTA_1572 Francisella tularensis subsp. holarctica FTNF002-00 uridine phosphorylase YP_001429003.1 1408759 D 458234 CDS YP_001429004.1 156502939 5523165 1409583..1409984 1 NC_009749.1 cytidine deaminase 1409984 cdd 5523165 cdd Francisella tularensis subsp. holarctica FTNF002-00 cytidine deaminase YP_001429004.1 1409583 D 458234 CDS YP_001429005.1 156502940 5524403 complement(1410176..1413211) 1 NC_009749.1 FAD-binding domain-containing protein 1413211 5524403 FTA_1574 Francisella tularensis subsp. holarctica FTNF002-00 FAD-binding domain-containing protein YP_001429005.1 1410176 R 458234 CDS YP_001429006.2 169656687 5523167 1413418..1414968 1 NC_009749.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 1414968 gpmI 5523167 gpmI Francisella tularensis subsp. holarctica FTNF002-00 phosphoglyceromutase YP_001429006.2 1413418 D 458234 CDS YP_001429007.1 156502942 5523168 1414983..1416263 1 NC_009749.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1416263 serS 5523168 serS Francisella tularensis subsp. holarctica FTNF002-00 seryl-tRNA synthetase YP_001429007.1 1414983 D 458234 CDS YP_001429008.1 156502943 5523169 1416373..1417272 1 NC_009749.1 ROK (repressor, ORF, kinase) family protein 1417272 5523169 FTA_1577 Francisella tularensis subsp. holarctica FTNF002-00 ROK (repressor, ORF, kinase) family protein YP_001429008.1 1416373 D 458234 CDS YP_001429009.1 156502944 5523170 1417350..1418609 1 NC_009749.1 polysaccharide biosynthesis protein 1418609 5523170 FTA_1578 Francisella tularensis subsp. holarctica FTNF002-00 polysaccharide biosynthesis protein YP_001429009.1 1417350 D 458234 CDS YP_001429010.1 156502945 5523171 complement(1418841..1419350) 1 NC_009749.1 hypothetical protein 1419350 5523171 FTA_1579 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429010.1 1418841 R 458234 CDS YP_001429011.1 156502946 5523013 1419727..1421508 1 NC_009749.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1421508 5523013 FTA_1580 Francisella tularensis subsp. holarctica FTNF002-00 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_001429011.1 1419727 D 458234 CDS YP_001429012.1 156502947 5523014 1421505..1423154 1 NC_009749.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1423154 5523014 FTA_1581 Francisella tularensis subsp. holarctica FTNF002-00 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_001429012.1 1421505 D 458234 CDS YP_001429013.1 156502948 5523015 complement(1423156..1424406) 1 NC_009749.1 C4-dicarboxylate transport protein 1424406 5523015 FTA_1582 Francisella tularensis subsp. holarctica FTNF002-00 C4-dicarboxylate transport protein YP_001429013.1 1423156 R 458234 CDS YP_001429014.1 156502949 5523016 complement(1424545..1424925) 1 NC_009749.1 endoribonuclease L-PSP 1424925 5523016 FTA_1583 Francisella tularensis subsp. holarctica FTNF002-00 endoribonuclease L-PSP YP_001429014.1 1424545 R 458234 CDS YP_001429015.1 156502950 5523017 complement(1424925..1426469) 1 NC_009749.1 sulfate permease family protein 1426469 5523017 FTA_1584 Francisella tularensis subsp. holarctica FTNF002-00 sulfate permease family protein YP_001429015.1 1424925 R 458234 CDS YP_001429016.1 156502951 5523018 complement(1426508..1427206) 1 NC_009749.1 transposase ISFTu2 1427206 5523018 FTA_1585 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001429016.1 1426508 R 458234 CDS YP_001429017.2 169656688 5523019 1427455..1428678 1 NC_009749.1 major facilitator transporter 1428678 5523019 FTA_1587 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001429017.2 1427455 D 458234 CDS YP_001429018.1 156502952 5523021 complement(1428662..1429987) 1 NC_009749.1 deoxyguanosinetriphosphate (dGTP) triphosphohydrolase 1429987 5523021 FTA_1586 Francisella tularensis subsp. holarctica FTNF002-00 deoxyguanosinetriphosphate (dGTP) triphosphohydrolase YP_001429018.1 1428662 R 458234 CDS YP_001429019.1 156502954 5523020 complement(1430091..1432316) 1 NC_009749.1 catalase/peroxidase HPI 1432316 katG 5523020 katG Francisella tularensis subsp. holarctica FTNF002-00 catalase/peroxidase HPI YP_001429019.1 1430091 R 458234 CDS YP_001429020.2 169656689 5523022 complement(join(1433085..1433636,1433636..1433965)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1433965 5523022 FTA_1589 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429020.2 1433085 R 458234 CDS YP_001429025.1 156502960 5523027 complement(1436457..1437773) 1 NC_009749.1 glycerol-3-phosphate transporter protein 1437773 5523027 FTA_1594 Francisella tularensis subsp. holarctica FTNF002-00 glycerol-3-phosphate transporter protein YP_001429025.1 1436457 R 458234 CDS YP_001429026.2 169656690 5523330 complement(1437880..1438914) 1 NC_009749.1 glycerophosphoryl diester phosphodiesterase family protein 1438914 5523330 FTA_1595 Francisella tularensis subsp. holarctica FTNF002-00 glycerophosphoryl diester phosphodiesterase family protein YP_001429026.2 1437880 R 458234 CDS YP_001429028.1 156502963 5523332 1440016..1440948 1 NC_009749.1 ABC transporter ATP-binding protein 1440948 5523332 FTA_1597 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter ATP-binding protein YP_001429028.1 1440016 D 458234 CDS YP_001429031.1 156502966 5523335 1442278..1442928 1 NC_009749.1 transposase ISFTu2 1442928 5523335 FTA_1600 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001429031.1 1442278 D 458234 CDS YP_001429032.1 156502967 5523336 complement(1442945..1443289) 1 NC_009749.1 hypothetical protein 1443289 5523336 FTA_1601 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429032.1 1442945 R 458234 CDS YP_001429035.2 169656691 5523339 complement(1444297..1444941) 1 NC_009749.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 1444941 upp 5523339 upp Francisella tularensis subsp. holarctica FTNF002-00 uracil phosphoribosyltransferase YP_001429035.2 1444297 R 458234 CDS YP_001429036.2 169656692 5523340 complement(1445118..1447442) 1 NC_009749.1 glycosyl hydrolase family protein 1447442 5523340 FTA_1605 Francisella tularensis subsp. holarctica FTNF002-00 glycosyl hydrolase family protein YP_001429036.2 1445118 R 458234 CDS YP_001429037.1 156502972 5523341 1447916..1449130 1 NC_009749.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 1449130 kbl 5523341 kbl Francisella tularensis subsp. holarctica FTNF002-00 2-amino-3-ketobutyrate coenzyme A ligase YP_001429037.1 1447916 D 458234 CDS YP_001429038.1 156502973 5523342 1449153..1450208 1 NC_009749.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 1450208 tdh 5523342 tdh Francisella tularensis subsp. holarctica FTNF002-00 L-threonine 3-dehydrogenase YP_001429038.1 1449153 D 458234 CDS YP_001429039.1 156502974 5523343 1450210..1451472 1 NC_009749.1 hypothetical protein 1451472 5523343 FTA_1608 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429039.1 1450210 D 458234 CDS YP_001429040.1 156502975 5523344 complement(1451477..1452166) 1 NC_009749.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1452166 ispD 5523344 ispD Francisella tularensis subsp. holarctica FTNF002-00 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_001429040.1 1451477 R 458234 CDS YP_001429041.1 156502976 5522831 complement(1452156..1452446) 1 NC_009749.1 putative septum formation initiator protein 1452446 5522831 FTA_1610 Francisella tularensis subsp. holarctica FTNF002-00 putative septum formation initiator protein YP_001429041.1 1452156 R 458234 CDS YP_001429042.1 156502977 5522832 complement(1452454..1453824) 1 NC_009749.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1453824 eno 5522832 eno Francisella tularensis subsp. holarctica FTNF002-00 phosphopyruvate hydratase YP_001429042.1 1452454 R 458234 CDS YP_001429043.1 156502978 5522833 complement(1453933..1455186) 1 NC_009749.1 major facilitator transporter 1455186 5522833 FTA_1612 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001429043.1 1453933 R 458234 CDS YP_001429044.1 156502979 5522834 complement(1455274..1455831) 1 NC_009749.1 nicotinamide mononucleotide transport (NMT) family protein 1455831 5522834 FTA_1613 Francisella tularensis subsp. holarctica FTNF002-00 nicotinamide mononucleotide transport (NMT) family protein YP_001429044.1 1455274 R 458234 CDS YP_001429045.1 156502980 5522835 complement(1456151..1456786) 1 NC_009749.1 putative ROK family protein 1456786 5522835 FTA_1614 Francisella tularensis subsp. holarctica FTNF002-00 putative ROK family protein YP_001429045.1 1456151 R 458234 CDS YP_001429046.1 156502981 5522836 complement(1456796..1458145) 1 NC_009749.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 1458145 rumA 5522836 rumA Francisella tularensis subsp. holarctica FTNF002-00 23S rRNA 5-methyluridine methyltransferase YP_001429046.1 1456796 R 458234 CDS YP_001429047.1 156502982 5522837 complement(1458234..1458806) 1 NC_009749.1 hypothetical protein 1458806 5522837 FTA_1616 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429047.1 1458234 R 458234 CDS YP_001429048.1 156502983 5524261 complement(1459070..1459288) 1 NC_009749.1 DNA-directed RNA polymerase subunit omega 1459288 rpoZ 5524261 rpoZ Francisella tularensis subsp. holarctica FTNF002-00 DNA-directed RNA polymerase subunit omega YP_001429048.1 1459070 R 458234 CDS YP_001429049.1 156502984 5522839 complement(1459281..1459946) 1 NC_009749.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1459946 udk 5522839 udk Francisella tularensis subsp. holarctica FTNF002-00 uridine kinase YP_001429049.1 1459281 R 458234 CDS YP_001429050.2 169656693 5522840 complement(1459957..1460805) 1 NC_009749.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1460805 kdsA 5522840 kdsA Francisella tularensis subsp. holarctica FTNF002-00 2-dehydro-3-deoxyphosphooctonate aldolase YP_001429050.2 1459957 R 458234 CDS YP_001429051.1 156502986 5522841 complement(1460815..1461165) 1 NC_009749.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 1461165 5522841 FTA_1620 Francisella tularensis subsp. holarctica FTNF002-00 iron-sulfur cluster insertion protein ErpA YP_001429051.1 1460815 R 458234 CDS YP_001429052.1 156502987 5522842 complement(1461171..1463252) 1 NC_009749.1 polynucleotide phosphorylase/polyadenylase 1463252 5522842 FTA_1621 Francisella tularensis subsp. holarctica FTNF002-00 polynucleotide phosphorylase/polyadenylase YP_001429052.1 1461171 R 458234 CDS YP_001429053.1 156502988 5522843 complement(1463309..1463575) 1 NC_009749.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1463575 rpsO 5522843 rpsO Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S15 YP_001429053.1 1463309 R 458234 CDS YP_001429054.2 169656694 5522844 complement(1463681..1465375) 1 NC_009749.1 penicillin-binding domain-containing protein 1465375 5522844 FTA_1623 Francisella tularensis subsp. holarctica FTNF002-00 penicillin-binding domain-containing protein YP_001429054.2 1463681 R 458234 CDS YP_001429055.2 169656695 5522845 complement(1465368..1465718) 1 NC_009749.1 cell division protein FtsL 1465718 5522845 FTA_1624 Francisella tularensis subsp. holarctica FTNF002-00 cell division protein FtsL YP_001429055.2 1465368 R 458234 CDS YP_001429056.2 169656696 5522755 complement(1465715..1466632) 1 NC_009749.1 S-adenosyl-methyltransferase MraW 1466632 mraW 5522755 mraW Francisella tularensis subsp. holarctica FTNF002-00 S-adenosyl-methyltransferase MraW YP_001429056.2 1465715 R 458234 CDS YP_001429057.1 156502992 5522756 complement(1466638..1468737) 1 NC_009749.1 AMP-binding domain-containing protein 1468737 5522756 FTA_1626 Francisella tularensis subsp. holarctica FTNF002-00 AMP-binding domain-containing protein YP_001429057.1 1466638 R 458234 CDS YP_001429058.1 156502993 5522757 1468830..1469654 1 NC_009749.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 1469654 mutM 5522757 mutM Francisella tularensis subsp. holarctica FTNF002-00 formamidopyrimidine-DNA glycosylase YP_001429058.1 1468830 D 458234 CDS YP_001429059.2 169656697 5522758 join(1469725..1470054,1470054..1470605) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1470605 5522758 FTA_1628 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429059.2 1469725 D 458234 CDS YP_001429061.2 169656698 5522760 complement(1470613..1471161) 1 NC_009749.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 1471161 5522760 FTA_1630 Francisella tularensis subsp. holarctica FTNF002-00 glutamine amidotransferase subunit PdxT YP_001429061.2 1470613 R 458234 CDS YP_001429062.1 156502997 5522761 complement(1471155..1472018) 1 NC_009749.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 1472018 5522761 FTA_1631 Francisella tularensis subsp. holarctica FTNF002-00 pyridoxal biosynthesis lyase PdxS YP_001429062.1 1471155 R 458234 CDS YP_001429063.2 169656699 5522762 complement(1472148..1474565) 1 NC_009749.1 DNA gyrase subunit B 1474565 gyrB 5522762 gyrB Francisella tularensis subsp. holarctica FTNF002-00 DNA gyrase subunit B YP_001429063.2 1472148 R 458234 CDS YP_001429064.1 156502999 5522763 complement(1474609..1474731) 1 NC_009749.1 hypothetical protein 1474731 5522763 FTA_1633 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429064.1 1474609 R 458234 CDS YP_001429065.2 169656700 5522764 1474741..1475541 1 NC_009749.1 hypothetical protein 1475541 5522764 FTA_1634 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429065.2 1474741 D 458234 CDS YP_001429066.2 169656701 5522765 1475575..1476558 1 NC_009749.1 tRNA-dihydrouridine synthase A 1476558 5522765 FTA_1635 Francisella tularensis subsp. holarctica FTNF002-00 tRNA-dihydrouridine synthase A YP_001429066.2 1475575 D 458234 CDS YP_001429067.1 156503002 5522766 complement(1476565..1477332) 1 NC_009749.1 putative lipoprotein 1477332 5522766 FTA_1636 Francisella tularensis subsp. holarctica FTNF002-00 putative lipoprotein YP_001429067.1 1476565 R 458234 CDS YP_001429068.1 156503003 5522767 1478000..1478314 1 NC_009749.1 hypothetical protein 1478314 5522767 FTA_1637 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429068.1 1478000 D 458234 CDS YP_001429069.1 156503004 5522768 complement(1478322..1480235) 1 NC_009749.1 hypothetical protein 1480235 5522768 FTA_1638 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429069.1 1478322 R 458234 CDS YP_001429070.1 156503005 5522769 1480405..1481568 1 NC_009749.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1481568 sucC 5522769 sucC Francisella tularensis subsp. holarctica FTNF002-00 succinyl-CoA synthetase subunit beta YP_001429070.1 1480405 D 458234 CDS YP_001429071.1 156503006 5522671 1481600..1482472 1 NC_009749.1 succinyl-CoA synthetase alpha chain 1482472 5522671 FTA_1640 Francisella tularensis subsp. holarctica FTNF002-00 succinyl-CoA synthetase alpha chain YP_001429071.1 1481600 D 458234 CDS YP_001429072.1 156503007 5522672 1482582..1483007 1 NC_009749.1 hypothetical protein 1483007 5522672 FTA_1641 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429072.1 1482582 D 458234 CDS YP_001429079.1 156503014 5522679 1487454..1488374 1 NC_009749.1 asparaginase 1488374 5522679 FTA_1648 Francisella tularensis subsp. holarctica FTNF002-00 asparaginase YP_001429079.1 1487454 D 458234 CDS YP_001429082.1 156503017 5522682 1489984..1490706 1 NC_009749.1 copper transport (CutC) family protein 1490706 5522682 FTA_1651 Francisella tularensis subsp. holarctica FTNF002-00 copper transport (CutC) family protein YP_001429082.1 1489984 D 458234 CDS YP_001429083.1 156503018 5522683 complement(1490721..1491887) 1 NC_009749.1 major facilitator transporter 1491887 5522683 FTA_1652 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001429083.1 1490721 R 458234 CDS YP_001429084.1 156503019 5522684 1491998..1492924 1 NC_009749.1 LysR family transcriptional regulator 1492924 5522684 FTA_1653 Francisella tularensis subsp. holarctica FTNF002-00 LysR family transcriptional regulator YP_001429084.1 1491998 D 458234 CDS YP_001429085.2 169656702 5522685 1492965..1493639 1 NC_009749.1 putative phosphoglycolate phosphatase 1493639 5522685 FTA_1654 Francisella tularensis subsp. holarctica FTNF002-00 putative phosphoglycolate phosphatase YP_001429085.2 1492965 D 458234 CDS YP_001715627.1 169656795 5983833 1494754..1494891 1 NC_009749.1 hypothetical protein 1494891 5983833 FTA_2151 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001715627.1 1494754 D 458234 CDS YP_001429087.1 156503022 5522657 1494983..1495933 1 NC_009749.1 thioredoxin reductase 1495933 trxB 5522657 trxB Francisella tularensis subsp. holarctica FTNF002-00 thioredoxin reductase YP_001429087.1 1494983 D 458234 CDS YP_001429088.1 156503023 5522658 1496202..1496888 1 NC_009749.1 transposase ISFTu2 1496888 5522658 FTA_1657 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001429088.1 1496202 D 458234 CDS YP_001429092.1 156503027 5522662 complement(1499157..1500959) 1 NC_009749.1 DNA mismatch repair protein 1500959 5522662 FTA_1661 Francisella tularensis subsp. holarctica FTNF002-00 DNA mismatch repair protein YP_001429092.1 1499157 R 458234 CDS YP_001429095.1 156503030 5522665 complement(1501698..1502417) 1 NC_009749.1 hypothetical protein 1502417 5522665 FTA_1664 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429095.1 1501698 R 458234 CDS YP_001429096.1 156503031 5522666 1502571..1503458 1 NC_009749.1 ribosome small subunit-dependent GTPase A 1503458 rsgA 5522666 rsgA Francisella tularensis subsp. holarctica FTNF002-00 ribosome small subunit-dependent GTPase A YP_001429096.1 1502571 D 458234 CDS YP_001429097.1 156503032 5522667 1503677..1504492 1 NC_009749.1 putative lipoprotein 1504492 5522667 FTA_1666 Francisella tularensis subsp. holarctica FTNF002-00 putative lipoprotein YP_001429097.1 1503677 D 458234 CDS YP_001429098.2 169656703 5522668 complement(1504745..1505926) 1 NC_009749.1 hypothetical protein 1505926 5522668 FTA_1667 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429098.2 1504745 R 458234 CDS YP_001429099.1 156503034 5522669 1506010..1507419 1 NC_009749.1 amino acid permease 1507419 5522669 FTA_1668 Francisella tularensis subsp. holarctica FTNF002-00 amino acid permease YP_001429099.1 1506010 D 458234 CDS YP_001429100.1 156503035 5522670 1507521..1508627 1 NC_009749.1 PerM family protein 1508627 5522670 FTA_1669 Francisella tularensis subsp. holarctica FTNF002-00 PerM family protein YP_001429100.1 1507521 D 458234 CDS YP_001429101.1 156503036 5524606 1508621..1510363 1 NC_009749.1 single-stranded-DNA-specific exonuclease RecJ 1510363 recJ 5524606 recJ Francisella tularensis subsp. holarctica FTNF002-00 single-stranded-DNA-specific exonuclease RecJ YP_001429101.1 1508621 D 458234 CDS YP_001429102.1 156503037 5524607 1510360..1511142 1 NC_009749.1 biotin--acetyl-CoA-carboxylase ligase 1511142 5524607 FTA_1671 Francisella tularensis subsp. holarctica FTNF002-00 biotin--acetyl-CoA-carboxylase ligase YP_001429102.1 1510360 D 458234 CDS YP_001429103.1 156503038 5524608 1511139..1512062 1 NC_009749.1 tRNA synthetases class II protein 1512062 5524608 FTA_1672 Francisella tularensis subsp. holarctica FTNF002-00 tRNA synthetases class II protein YP_001429103.1 1511139 D 458234 CDS YP_001429105.1 156503040 5524610 complement(1512772..1513530) 1 NC_009749.1 transposase ISFTu2 1513530 5524610 FTA_1674 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001429105.1 1512772 R 458234 CDS YP_001429107.1 156503042 5524612 complement(1514091..1514771) 1 NC_009749.1 hypothetical protein 1514771 5524612 FTA_1676 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429107.1 1514091 R 458234 CDS YP_001429108.1 156503043 5524613 complement(1514865..1516220) 1 NC_009749.1 acetyl-CoA carboxylase, biotin carboxylase 1516220 accC 5524613 accC Francisella tularensis subsp. holarctica FTNF002-00 acetyl-CoA carboxylase, biotin carboxylase YP_001429108.1 1514865 R 458234 CDS YP_001429109.1 156503044 5524614 complement(1516285..1516758) 1 NC_009749.1 acetyl-CoA carboxylase, biotin carboxyl carrier protein 1516758 accB 5524614 accB Francisella tularensis subsp. holarctica FTNF002-00 acetyl-CoA carboxylase, biotin carboxyl carrier protein YP_001429109.1 1516285 R 458234 CDS YP_001429110.1 156503045 5524615 complement(1516763..1517200) 1 NC_009749.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 1517200 5524615 FTA_1679 Francisella tularensis subsp. holarctica FTNF002-00 3-dehydroquinate dehydratase YP_001429110.1 1516763 R 458234 CDS YP_001429111.1 156503046 5524616 complement(1517204..1518031) 1 NC_009749.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 1518031 apaH 5524616 apaH Francisella tularensis subsp. holarctica FTNF002-00 diadenosine tetraphosphatase YP_001429111.1 1517204 R 458234 CDS YP_001429112.1 156503047 5524617 complement(1518043..1518831) 1 NC_009749.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1518831 ksgA 5524617 ksgA Francisella tularensis subsp. holarctica FTNF002-00 dimethyladenosine transferase YP_001429112.1 1518043 R 458234 CDS YP_001429113.2 169656704 5524618 complement(1518833..1520260) 1 NC_009749.1 hypothetical protein 1520260 5524618 FTA_1682 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429113.2 1518833 R 458234 CDS YP_001429114.1 156503049 5524619 complement(1520242..1522848) 1 NC_009749.1 organic solvent tolerance protein 1522848 5524619 FTA_1683 Francisella tularensis subsp. holarctica FTNF002-00 organic solvent tolerance protein YP_001429114.1 1520242 R 458234 CDS YP_001429115.1 156503050 5524620 1522974..1524719 1 NC_009749.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1524719 argS 5524620 argS Francisella tularensis subsp. holarctica FTNF002-00 arginyl-tRNA synthetase YP_001429115.1 1522974 D 458234 CDS YP_001429118.1 156503053 5522963 complement(1526757..1527224) 1 NC_009749.1 tRNA/rRNA methyltransferase 1527224 5522963 FTA_1687 Francisella tularensis subsp. holarctica FTNF002-00 tRNA/rRNA methyltransferase YP_001429118.1 1526757 R 458234 CDS YP_001429119.1 156503054 5522964 complement(1527228..1528202) 1 NC_009749.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 1528202 hemB 5522964 hemB Francisella tularensis subsp. holarctica FTNF002-00 delta-aminolevulinic acid dehydratase YP_001429119.1 1527228 R 458234 CDS YP_001429120.1 156503055 5522965 complement(1528210..1528488) 1 NC_009749.1 CRS1/YhbY domain, RNA-binding protein 1528488 5522965 FTA_1689 Francisella tularensis subsp. holarctica FTNF002-00 CRS1/YhbY domain, RNA-binding protein YP_001429120.1 1528210 R 458234 CDS YP_001429121.1 156503056 5522966 complement(1528499..1529410) 1 NC_009749.1 DNA polymerase III subunit delta' 1529410 5522966 FTA_1690 Francisella tularensis subsp. holarctica FTNF002-00 DNA polymerase III subunit delta' YP_001429121.1 1528499 R 458234 CDS YP_001429122.1 156503057 5522967 complement(1529418..1530434) 1 NC_009749.1 SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease 1530434 5522967 FTA_1691 Francisella tularensis subsp. holarctica FTNF002-00 putative periplasmic protease YP_001429122.1 1529418 R 458234 CDS YP_001429123.2 169656705 5522968 complement(1530446..1531078) 1 NC_009749.1 glutathione S-transferase domain-containing protein 1531078 5522968 FTA_1692 Francisella tularensis subsp. holarctica FTNF002-00 glutathione S-transferase domain-containing protein YP_001429123.2 1530446 R 458234 CDS YP_001429124.2 169656706 5522969 1531164..1531478 1 NC_009749.1 DsrC (dissimilatory sulfite reductase)-like protein 1531478 5522969 FTA_1693 Francisella tularensis subsp. holarctica FTNF002-00 DsrC (dissimilatory sulfite reductase)-like protein YP_001429124.2 1531164 D 458234 CDS YP_001429125.2 169656707 5522970 1531469..1531762 1 NC_009749.1 hypothetical protein 1531762 5522970 FTA_1694 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429125.2 1531469 D 458234 CDS YP_001429126.1 156503061 5522971 1531854..1533614 1 NC_009749.1 dolichyl-phosphate-mannose-protein mannosyltransferase family protein 1533614 5522971 FTA_1695 Francisella tularensis subsp. holarctica FTNF002-00 dolichyl-phosphate-mannose-protein mannosyltransferase family protein YP_001429126.1 1531854 D 458234 CDS YP_001429127.2 169656708 5522972 complement(join(1533899..1534450,1534450..1534779)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1534779 5522972 FTA_1696 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429127.2 1533899 R 458234 CDS YP_001429129.2 169656709 5522974 1534770..1534928 1 NC_009749.1 hypothetical protein 1534928 5522974 FTA_1698 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429129.2 1534770 D 458234 CDS YP_001429130.2 169656710 5522975 complement(1534938..1535894) 1 NC_009749.1 glycosyl transferase family protein 1535894 5522975 FTA_1699 Francisella tularensis subsp. holarctica FTNF002-00 glycosyl transferase family protein YP_001429130.2 1534938 R 458234 CDS YP_001429131.1 156503066 5522984 1535993..1536799 1 NC_009749.1 hypothetical protein 1536799 5522984 FTA_1700 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429131.1 1535993 D 458234 CDS YP_001429132.2 169656711 5522985 complement(1536807..1538012) 1 NC_009749.1 cell division protein FtsW 1538012 ftsW 5522985 ftsW Francisella tularensis subsp. holarctica FTNF002-00 cell division protein FtsW YP_001429132.2 1536807 R 458234 CDS YP_001429133.1 156503068 5522986 complement(1538022..1539272) 1 NC_009749.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase 1539272 murD 5522986 murD Francisella tularensis subsp. holarctica FTNF002-00 UDP-N-acetylmuramoylalanine--D-glutamate ligase YP_001429133.1 1538022 R 458234 CDS YP_001429134.1 156503069 5522987 complement(1539272..1540369) 1 NC_009749.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1540369 mraY 5522987 mraY Francisella tularensis subsp. holarctica FTNF002-00 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_001429134.1 1539272 R 458234 CDS YP_001429135.2 169656712 5522988 complement(1540444..1542036) 1 NC_009749.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 1542036 pckA 5522988 pckA Francisella tularensis subsp. holarctica FTNF002-00 phosphoenolpyruvate carboxykinase YP_001429135.2 1540444 R 458234 CDS YP_001429136.1 156503071 5522989 1542181..1543827 1 NC_009749.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 1543827 glnS 5522989 glnS Francisella tularensis subsp. holarctica FTNF002-00 glutaminyl-tRNA synthetase YP_001429136.1 1542181 D 458234 CDS YP_001429140.2 169656713 5522993 complement(1545332..1545820) 1 NC_009749.1 hypothetical protein 1545820 5522993 FTA_1709 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429140.2 1545332 R 458234 CDS YP_001429141.1 156503076 5522994 complement(1545877..1547718) 1 NC_009749.1 ABC transporter ATP-binding protein 1547718 5522994 FTA_1710 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter ATP-binding protein YP_001429141.1 1545877 R 458234 CDS YP_001429142.2 169656714 5522995 complement(1547752..1548978) 1 NC_009749.1 major facilitator transporter 1548978 5522995 FTA_1711 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001429142.2 1547752 R 458234 CDS YP_001429143.1 156503078 5522996 complement(1549061..1550104) 1 NC_009749.1 hypothetical protein 1550104 5522996 FTA_1712 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429143.1 1549061 R 458234 CDS YP_001429145.1 156503080 5522998 1551579..1552223 1 NC_009749.1 hypothetical protein 1552223 5522998 FTA_1714 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429145.1 1551579 D 458234 CDS YP_001429146.2 169656715 5523660 complement(1552239..1552430) 1 NC_009749.1 hypothetical protein 1552430 5523660 FTA_1715 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429146.2 1552239 R 458234 CDS YP_001429147.2 169656716 5523661 join(1552421..1552750,1552750..1553301) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1553301 5523661 FTA_1716 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429147.2 1552421 D 458234 CDS YP_001429152.2 169656717 5523666 complement(join(1555899..1556450,1556450..1556779)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1556779 5523666 FTA_1721 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429152.2 1555899 R 458234 CDS YP_001429154.1 156503089 5523668 complement(1556841..1557875) 1 NC_009749.1 hypothetical protein 1557875 5523668 FTA_1723 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429154.1 1556841 R 458234 CDS YP_001429156.1 156503091 5523670 complement(1558209..1558934) 1 NC_009749.1 hypothetical protein 1558934 5523670 FTA_1725 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429156.1 1558209 R 458234 CDS YP_001429157.2 169656718 5523671 complement(1559115..1560107) 1 NC_009749.1 LysR family transcriptional regulator 1560107 5523671 FTA_1726 Francisella tularensis subsp. holarctica FTNF002-00 LysR family transcriptional regulator YP_001429157.2 1559115 R 458234 CDS YP_001429161.1 156503096 5523830 1563683..1563844 1 NC_009749.1 hypothetical protein 1563844 5523830 FTA_1730 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429161.1 1563683 D 458234 CDS YP_001429163.1 156503098 5523832 1565277..1565972 1 NC_009749.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 1565972 ubiG 5523832 ubiG Francisella tularensis subsp. holarctica FTNF002-00 3-demethylubiquinone-9 3-methyltransferase YP_001429163.1 1565277 D 458234 CDS YP_001429164.1 156503099 5523833 1565975..1566718 1 NC_009749.1 hypothetical protein 1566718 5523833 FTA_1733 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429164.1 1565975 D 458234 CDS YP_001429165.1 156503100 5523834 1566715..1566951 1 NC_009749.1 hypothetical protein 1566951 5523834 FTA_1734 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429165.1 1566715 D 458234 CDS YP_001429166.2 169656719 5523835 1567084..1568586 1 NC_009749.1 amino acid permease 1568586 5523835 FTA_1735 Francisella tularensis subsp. holarctica FTNF002-00 amino acid permease YP_001429166.2 1567084 D 458234 CDS YP_001429167.1 156503102 5523836 1568599..1568880 1 NC_009749.1 hypothetical protein 1568880 5523836 FTA_1736 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429167.1 1568599 D 458234 CDS YP_001429168.2 169656720 5523837 complement(1568894..1569133) 1 NC_009749.1 hypothetical protein 1569133 5523837 FTA_1737 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429168.2 1568894 R 458234 CDS YP_001429169.2 169656721 5523838 join(1569124..1569453,1569453..1570004) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1570004 5523838 FTA_1738 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429169.2 1569124 D 458234 CDS YP_001429171.1 156503105 5523841 complement(1570001..1571509) 1 NC_009749.1 glycerol kinase 1571509 glpK 5523841 glpK Francisella tularensis subsp. holarctica FTNF002-00 glycerol kinase YP_001429171.1 1570001 R 458234 CDS YP_001429172.1 156503107 5523840 complement(1571577..1572788) 1 NC_009749.1 major facilitator transporter 1572788 5523840 FTA_1741 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001429172.1 1571577 R 458234 CDS YP_001429173.1 156503108 5523842 1572802..1572927 1 NC_009749.1 hypothetical protein 1572927 5523842 FTA_1742 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429173.1 1572802 D 458234 CDS YP_001429174.1 156503109 5523843 complement(1572948..1573559) 1 NC_009749.1 hypothetical protein 1573559 5523843 FTA_1743 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429174.1 1572948 R 458234 CDS YP_001429175.2 169656722 5523844 1573693..1574895 1 NC_009749.1 major facilitator transporter 1574895 5523844 FTA_1744 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001429175.2 1573693 D 458234 CDS YP_001429176.1 156503111 5524494 complement(1575064..1575867) 1 NC_009749.1 ABC transporter ATP-binding protein 1575867 5524494 FTA_1745 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter ATP-binding protein YP_001429176.1 1575064 R 458234 CDS YP_001429183.1 156503118 5524501 complement(1579403..1580053) 1 NC_009749.1 transposase ISFTu2 1580053 5524501 FTA_1752 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001429183.1 1579403 R 458234 CDS YP_001429184.1 156503119 5524502 complement(1580317..1582539) 1 NC_009749.1 DNA helicase II 1582539 5524502 FTA_1753 Francisella tularensis subsp. holarctica FTNF002-00 DNA helicase II YP_001429184.1 1580317 R 458234 CDS YP_001429185.2 169656723 5524503 complement(1582630..1583661) 1 NC_009749.1 signal recognition particle-docking protein FtsY 1583661 ftsY 5524503 ftsY Francisella tularensis subsp. holarctica FTNF002-00 signal recognition particle-docking protein FtsY YP_001429185.2 1582630 R 458234 CDS YP_001429186.1 156503121 5524504 complement(1583658..1584974) 1 NC_009749.1 LysM domain-containing protein 1584974 5524504 FTA_1755 Francisella tularensis subsp. holarctica FTNF002-00 LysM domain-containing protein YP_001429186.1 1583658 R 458234 CDS YP_001429187.1 156503122 5524505 complement(1585049..1586626) 1 NC_009749.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 1586626 prfC 5524505 prfC Francisella tularensis subsp. holarctica FTNF002-00 peptide chain release factor 3 YP_001429187.1 1585049 R 458234 CDS YP_001429188.1 156503123 5524506 complement(1586688..1587317) 1 NC_009749.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1587317 tmk 5524506 tmk Francisella tularensis subsp. holarctica FTNF002-00 thymidylate kinase YP_001429188.1 1586688 R 458234 CDS YP_001429189.1 156503124 5524507 complement(1587330..1588532) 1 NC_009749.1 nucleoside permease, NupC family protein 1588532 5524507 FTA_1758 Francisella tularensis subsp. holarctica FTNF002-00 nucleoside permease, NupC family protein YP_001429189.1 1587330 R 458234 CDS YP_001429190.1 156503125 5524508 complement(1588551..1589750) 1 NC_009749.1 nucleoside permease, NupC family protein 1589750 5524508 FTA_1759 Francisella tularensis subsp. holarctica FTNF002-00 nucleoside permease, NupC family protein YP_001429190.1 1588551 R 458234 CDS YP_001429191.2 169656724 5524000 complement(1589740..1590501) 1 NC_009749.1 deoxyribose-phosphate aldolase 1590501 deoC 5524000 deoC Francisella tularensis subsp. holarctica FTNF002-00 deoxyribose-phosphate aldolase YP_001429191.2 1589740 R 458234 CDS YP_001429192.1 156503127 5524001 complement(1590464..1591708) 1 NC_009749.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 1591708 deoB 5524001 deoB Francisella tularensis subsp. holarctica FTNF002-00 phosphopentomutase YP_001429192.1 1590464 R 458234 CDS YP_001429193.1 156503128 5524002 complement(1591713..1592477) 1 NC_009749.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 1592477 5524002 FTA_1762 Francisella tularensis subsp. holarctica FTNF002-00 pantothenate kinase YP_001429193.1 1591713 R 458234 CDS YP_001429194.1 156503129 5524003 complement(1592497..1595190) 1 NC_009749.1 DNA polymerase I 1595190 polA 5524003 polA Francisella tularensis subsp. holarctica FTNF002-00 DNA polymerase I YP_001429194.1 1592497 R 458234 CDS YP_001429195.2 169656725 5524004 complement(1595286..1596254) 1 NC_009749.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 1596254 lpxK 5524004 lpxK Francisella tularensis subsp. holarctica FTNF002-00 tetraacyldisaccharide 4'-kinase YP_001429195.2 1595286 R 458234 CDS YP_001429197.1 156503132 5524006 1598194..1599276 1 NC_009749.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 1599276 5524006 FTA_1766 Francisella tularensis subsp. holarctica FTNF002-00 tRNA CCA-pyrophosphorylase YP_001429197.1 1598194 D 458234 CDS YP_001429198.1 156503133 5524007 1599316..1599807 1 NC_009749.1 disulfide bond formation protein 1599807 5524007 FTA_1767 Francisella tularensis subsp. holarctica FTNF002-00 disulfide bond formation protein YP_001429198.1 1599316 D 458234 CDS YP_001429199.1 156503134 5524008 1599820..1601193 1 NC_009749.1 MFP (membrane fusion protein) subunit, RND family protein 1601193 5524008 FTA_1768 Francisella tularensis subsp. holarctica FTNF002-00 MFP (membrane fusion protein) subunit, RND family protein YP_001429199.1 1599820 D 458234 CDS YP_001429200.1 156503135 5524009 1601193..1604306 1 NC_009749.1 RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family protein 1604306 5524009 FTA_1769 Francisella tularensis subsp. holarctica FTNF002-00 RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family protein YP_001429200.1 1601193 D 458234 CDS YP_001429201.2 169656726 5524010 1604438..1605718 1 NC_009749.1 major facilitator transporter 1605718 5524010 FTA_1770 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001429201.2 1604438 D 458234 CDS YP_001429202.1 156503137 5524011 1605963..1606544 1 NC_009749.1 hypothetical protein 1606544 5524011 FTA_1771 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429202.1 1605963 D 458234 CDS YP_001429203.1 156503138 5524012 complement(1606681..1606809) 1 NC_009749.1 hypothetical protein 1606809 5524012 FTA_1772 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429203.1 1606681 R 458234 CDS YP_001429206.2 169656727 5522585 complement(1607989..1609002) 1 NC_009749.1 LD-carboxypeptidase family protein 1609002 5522585 FTA_1775 Francisella tularensis subsp. holarctica FTNF002-00 LD-carboxypeptidase family protein YP_001429206.2 1607989 R 458234 CDS YP_001429207.1 156503142 5522586 complement(1609231..1609584) 1 NC_009749.1 IS1016 family transposase 1609584 5522586 FTA_1776 Francisella tularensis subsp. holarctica FTNF002-00 IS1016 family transposase YP_001429207.1 1609231 R 458234 CDS YP_001429208.1 156503143 5522587 complement(1609610..1610290) 1 NC_009749.1 transposase ISFTu2 1610290 5522587 FTA_1777 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001429208.1 1609610 R 458234 CDS YP_001429209.2 169656728 5522588 join(1610568..1610897,1610897..1611448) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1611448 5522588 FTA_1778 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429209.2 1610568 D 458234 CDS YP_001429212.1 156503147 5522591 1611819..1613213 1 NC_009749.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1613213 cysS 5522591 cysS Francisella tularensis subsp. holarctica FTNF002-00 cysteinyl-tRNA synthetase YP_001429212.1 1611819 D 458234 CDS YP_001429213.1 156503148 5522592 1613217..1614161 1 NC_009749.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1614161 5522592 FTA_1782 Francisella tularensis subsp. holarctica FTNF002-00 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_001429213.1 1613217 D 458234 CDS YP_001429214.1 156503149 5522593 1614217..1615404 1 NC_009749.1 major facilitator transporter 1615404 5522593 FTA_1783 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001429214.1 1614217 D 458234 CDS YP_001429215.2 169656729 5522594 1615418..1615909 1 NC_009749.1 acetyltransferase 1615909 5522594 FTA_1784 Francisella tularensis subsp. holarctica FTNF002-00 acetyltransferase YP_001429215.2 1615418 D 458234 CDS YP_001429216.2 169656730 5522595 join(1616055..1616384,1616384..1616935) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1616935 5522595 FTA_1785 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429216.2 1616055 D 458234 CDS YP_001429218.1 156503153 5522597 complement(1617248..1618099) 1 NC_009749.1 hypothetical protein 1618099 5522597 FTA_1787 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429218.1 1617248 R 458234 CDS YP_001429219.1 156503154 5522598 complement(1618103..1619032) 1 NC_009749.1 hypothetical protein 1619032 5522598 FTA_1788 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429219.1 1618103 R 458234 CDS YP_001429224.1 156503159 5523117 complement(1621738..1622541) 1 NC_009749.1 prepilin-type N- terminal cleavage/methylation domain-containing protein 1622541 5523117 FTA_1793 Francisella tularensis subsp. holarctica FTNF002-00 prepilin-type N- terminal cleavage/methylation domain-containing protein YP_001429224.1 1621738 R 458234 CDS YP_001429225.2 169656731 5523118 complement(1622525..1622872) 1 NC_009749.1 hypothetical protein 1622872 5523118 FTA_1794 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429225.2 1622525 R 458234 CDS YP_001429229.1 156503164 5523122 complement(1624256..1625935) 1 NC_009749.1 glycosyltransferase, group 2 family protein 1625935 5523122 FTA_1798 Francisella tularensis subsp. holarctica FTNF002-00 glycosyltransferase, group 2 family protein YP_001429229.1 1624256 R 458234 CDS YP_001429231.1 156503166 5523124 complement(1627779..1628765) 1 NC_009749.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 1628765 glpX 5523124 glpX Francisella tularensis subsp. holarctica FTNF002-00 fructose 1,6-bisphosphatase II YP_001429231.1 1627779 R 458234 CDS YP_001429232.1 156503167 5523125 complement(1628785..1629423) 1 NC_009749.1 hypothetical protein 1629423 5523125 FTA_1801 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429232.1 1628785 R 458234 CDS YP_001429233.2 169656732 5523126 complement(1629432..1630886) 1 NC_009749.1 amino acid permease 1630886 5523126 FTA_1802 Francisella tularensis subsp. holarctica FTNF002-00 amino acid permease YP_001429233.2 1629432 R 458234 CDS YP_001429234.2 169656733 5523127 complement(1631133..1631801) 1 NC_009749.1 PAP2 (2 phosphatidic acid phosphatase) family protein 1631801 5523127 FTA_1803 Francisella tularensis subsp. holarctica FTNF002-00 PAP2 (2 phosphatidic acid phosphatase) family protein YP_001429234.2 1631133 R 458234 CDS YP_001429235.1 156503170 5523128 1631923..1634424 1 NC_009749.1 cell division protein FtsK 1634424 5523128 FTA_1804 Francisella tularensis subsp. holarctica FTNF002-00 cell division protein FtsK YP_001429235.1 1631923 D 458234 CDS YP_001429236.1 156503171 5524087 1634425..1635042 1 NC_009749.1 lipoprotein releasing system subunit A, outer membrane lipoproteins carrier 1635042 lolA 5524087 lolA Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein releasing system subunit A, outer membrane lipoproteins carrier YP_001429236.1 1634425 D 458234 CDS YP_001429237.1 156503172 5524088 complement(1635056..1635187) 1 NC_009749.1 hypothetical protein 1635187 5524088 FTA_1806 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429237.1 1635056 R 458234 CDS YP_001429238.2 169656734 5524089 complement(1635436..1635639) 1 NC_009749.1 hypothetical protein 1635639 5524089 FTA_1807 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429238.2 1635436 R 458234 CDS YP_001429239.2 169656735 5524090 1635751..1637205 1 NC_009749.1 cation efflux transporter 1637205 5524090 FTA_1808 Francisella tularensis subsp. holarctica FTNF002-00 cation efflux transporter YP_001429239.2 1635751 D 458234 CDS YP_001429240.2 169656736 5524091 complement(1637220..1637765) 1 NC_009749.1 putative lipoprotein 1637765 5524091 FTA_1809 Francisella tularensis subsp. holarctica FTNF002-00 putative lipoprotein YP_001429240.2 1637220 R 458234 CDS YP_001429241.1 156503176 5524092 complement(1637788..1638489) 1 NC_009749.1 putative activator of osmoprotectant transporter 1638489 5524092 FTA_1810 Francisella tularensis subsp. holarctica FTNF002-00 putative activator of osmoprotectant transporter YP_001429241.1 1637788 R 458234 CDS YP_001429242.1 156503177 5524093 complement(1638509..1638658) 1 NC_009749.1 hypothetical protein 1638658 5524093 FTA_1811 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429242.1 1638509 R 458234 CDS YP_001429245.2 169656737 5524096 join(1640169..1640498,1640498..1641049) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1641049 5524096 FTA_1814 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429245.2 1640169 D 458234 CDS YP_001429247.2 169656738 5524098 complement(1641169..1642848) 1 NC_009749.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 1642848 groEL 5524098 groEL Francisella tularensis subsp. holarctica FTNF002-00 chaperonin GroEL YP_001429247.2 1641169 R 458234 CDS YP_001429248.1 156503183 5524099 complement(1642841..1643128) 1 NC_009749.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1643128 groES 5524099 groES Francisella tularensis subsp. holarctica FTNF002-00 co-chaperonin GroES YP_001429248.1 1642841 R 458234 CDS YP_001429249.2 169656739 5524100 1643371..1643805 1 NC_009749.1 hypothetical protein 1643805 5524100 FTA_1818 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429249.2 1643371 D 458234 CDS YP_001429250.1 156503185 5524152 1644416..1645210 1 NC_009749.1 hypothetical protein 1645210 5524152 FTA_1819 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429250.1 1644416 D 458234 CDS YP_001429251.2 169656740 5522727 complement(join(1645261..1645812,1645812..1646141)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1646141 5522727 FTA_1820 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429251.2 1645261 R 458234 CDS YP_001429253.2 169656741 5522729 1646132..1646632 1 NC_009749.1 hypothetical protein 1646632 5522729 FTA_1823 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429253.2 1646132 D 458234 CDS YP_001429254.1 156503188 5522731 complement(1646623..1647477) 1 NC_009749.1 methyltransferase, HemK family protein 1647477 5522731 FTA_1822 Francisella tularensis subsp. holarctica FTNF002-00 methyltransferase, HemK family protein YP_001429254.1 1646623 R 458234 CDS YP_001429255.1 156503190 5522730 complement(1647470..1648555) 1 NC_009749.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1648555 prfA 5522730 prfA Francisella tularensis subsp. holarctica FTNF002-00 peptide chain release factor 1 YP_001429255.1 1647470 R 458234 CDS YP_001429256.2 169656742 5522732 complement(1648556..1649806) 1 NC_009749.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1649806 hemA 5522732 hemA Francisella tularensis subsp. holarctica FTNF002-00 glutamyl-tRNA reductase YP_001429256.2 1648556 R 458234 CDS YP_001429257.1 156503192 5522733 1649980..1650618 1 NC_009749.1 hypothetical protein 1650618 5522733 FTA_1826 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429257.1 1649980 D 458234 CDS YP_001429258.1 156503193 5522734 1650621..1651991 1 NC_009749.1 lipoprotein 1651991 5522734 FTA_1827 Francisella tularensis subsp. holarctica FTNF002-00 lipoprotein YP_001429258.1 1650621 D 458234 CDS YP_001429259.1 156503194 5522735 1651991..1653172 1 NC_009749.1 Bcr/CflA subfamily drug resistance transporter 1653172 5522735 FTA_1828 Francisella tularensis subsp. holarctica FTNF002-00 Bcr/CflA subfamily drug resistance transporter YP_001429259.1 1651991 D 458234 CDS YP_001429260.1 156503195 5522736 1653262..1655145 1 NC_009749.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 1655145 parE 5522736 parE Francisella tularensis subsp. holarctica FTNF002-00 DNA topoisomerase IV subunit B YP_001429260.1 1653262 D 458234 CDS YP_001429261.1 156503196 5522737 complement(1655193..1655717) 1 NC_009749.1 N-acetyl-anhydromuranmyl-L-alanine amidase 1655717 5522737 FTA_1830 Francisella tularensis subsp. holarctica FTNF002-00 N-acetyl-anhydromuranmyl-L-alanine amidase YP_001429261.1 1655193 R 458234 CDS YP_001429262.1 156503197 5522738 1655791..1656417 1 NC_009749.1 PAP2 family protein 1656417 5522738 FTA_1831 Francisella tularensis subsp. holarctica FTNF002-00 PAP2 family protein YP_001429262.1 1655791 D 458234 CDS YP_001429263.1 156503198 5522739 complement(1656427..1656894) 1 NC_009749.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 1656894 5522739 FTA_1832 Francisella tularensis subsp. holarctica FTNF002-00 dinucleoside polyphosphate hydrolase YP_001429263.1 1656427 R 458234 CDS YP_001429265.1 156503201 5522741 1658698..1659582 1 NC_009749.1 licB-like transmembrane protein 1659582 5522741 FTA_1835 Francisella tularensis subsp. holarctica FTNF002-00 licB-like transmembrane protein YP_001429265.1 1658698 D 458234 CDS YP_001429266.1 156503200 5523603 complement(1659579..1660163) 1 NC_009749.1 HAD superfamily acid phosphatase 1660163 5523603 FTA_1834 Francisella tularensis subsp. holarctica FTNF002-00 HAD superfamily acid phosphatase YP_001429266.1 1659579 R 458234 CDS YP_001429267.2 169656743 5523602 complement(1660168..1661019) 1 NC_009749.1 iron/ascorbate family oxidoreductase 1661019 5523602 FTA_1836 Francisella tularensis subsp. holarctica FTNF002-00 iron/ascorbate family oxidoreductase YP_001429267.2 1660168 R 458234 CDS YP_001429268.1 156503203 5523604 complement(1661136..1662014) 1 NC_009749.1 tyrosine recombinase XerD 1662014 xerD 5523604 xerD Francisella tularensis subsp. holarctica FTNF002-00 tyrosine recombinase XerD YP_001429268.1 1661136 R 458234 CDS YP_001429269.1 156503204 5523605 complement(1662180..1662527) 1 NC_009749.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1662527 rplS 5523605 rplS Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L19 YP_001429269.1 1662180 R 458234 CDS YP_001429270.2 169656744 5523606 complement(1662527..1663291) 1 NC_009749.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 1663291 trmD 5523606 trmD Francisella tularensis subsp. holarctica FTNF002-00 tRNA (guanine-N(1)-)-methyltransferase YP_001429270.2 1662527 R 458234 CDS YP_001429271.1 156503206 5523607 complement(1663688..1664197) 1 NC_009749.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 1664197 rimM 5523607 rimM Francisella tularensis subsp. holarctica FTNF002-00 16S rRNA-processing protein RimM YP_001429271.1 1663688 R 458234 CDS YP_001429272.2 169656745 5523608 complement(1664240..1664488) 1 NC_009749.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 1664488 rpsP 5523608 rpsP Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S16 YP_001429272.2 1664240 R 458234 CDS YP_001429273.1 156503208 5523609 1664782..1665942 1 NC_009749.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1665942 metK 5523609 metK Francisella tularensis subsp. holarctica FTNF002-00 S-adenosylmethionine synthetase YP_001429273.1 1664782 D 458234 CDS YP_001429274.1 156503209 5523610 complement(1666154..1667320) 1 NC_009749.1 fatty acid desaturase 1667320 5523610 FTA_1843 Francisella tularensis subsp. holarctica FTNF002-00 fatty acid desaturase YP_001429274.1 1666154 R 458234 CDS YP_001429275.1 156503210 5523611 complement(1667434..1668444) 1 NC_009749.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 1668444 5523611 FTA_1844 Francisella tularensis subsp. holarctica FTNF002-00 putative DNA-binding/iron metalloprotein/AP endonuclease YP_001429275.1 1667434 R 458234 CDS YP_001429276.1 156503211 5523612 complement(1668444..1668680) 1 NC_009749.1 hypothetical protein 1668680 5523612 FTA_1845 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429276.1 1668444 R 458234 CDS YP_001429279.1 156503214 5523615 complement(1673098..1677183) 1 NC_009749.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1677183 rpoB 5523615 rpoB Francisella tularensis subsp. holarctica FTNF002-00 DNA-directed RNA polymerase subunit beta YP_001429279.1 1673098 R 458234 CDS YP_001429280.1 156503215 5523616 complement(1677328..1677705) 1 NC_009749.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1677705 rplL 5523616 rplL Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L7/L12 YP_001429280.1 1677328 R 458234 CDS YP_001429281.1 156503216 5524449 complement(1677767..1678285) 1 NC_009749.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1678285 rplJ 5524449 rplJ Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L10 YP_001429281.1 1677767 R 458234 CDS YP_001429282.2 169656746 5524450 complement(1678455..1679153) 1 NC_009749.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 1679153 rplA 5524450 rplA Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L1 YP_001429282.2 1678455 R 458234 CDS YP_001429283.2 169656747 5524451 complement(1679153..1679599) 1 NC_009749.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 1679599 rplK 5524451 rplK Francisella tularensis subsp. holarctica FTNF002-00 50S ribosomal protein L11 YP_001429283.2 1679153 R 458234 CDS YP_001429284.2 169656748 5524452 complement(1679656..1680189) 1 NC_009749.1 transcription termination/antitermination factor NusG 1680189 nusG 5524452 nusG Francisella tularensis subsp. holarctica FTNF002-00 transcription termination/antitermination factor NusG YP_001429284.2 1679656 R 458234 CDS YP_001429285.2 169656749 5524453 complement(1680205..1680675) 1 NC_009749.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1680675 secE 5524453 secE Francisella tularensis subsp. holarctica FTNF002-00 preprotein translocase subunit SecE YP_001429285.2 1680205 R 458234 CDS YP_001429286.1 156503221 5524654 complement(1680867..1682051) 1 NC_009749.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1682051 tufA 5524654 tufA Francisella tularensis subsp. holarctica FTNF002-00 elongation factor Tu YP_001429286.1 1680867 R 458234 CDS YP_001429287.2 169656750 5524219 complement(1682516..1683763) 1 NC_009749.1 hypothetical protein 1683763 5524219 FTA_1856 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429287.2 1682516 R 458234 CDS YP_001429288.1 156503223 5524456 complement(1683930..1684427) 1 NC_009749.1 hypothetical protein 1684427 5524456 FTA_1857 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429288.1 1683930 R 458234 CDS YP_001429289.1 156503224 5524457 complement(1684405..1685118) 1 NC_009749.1 hypothetical protein 1685118 5524457 FTA_1858 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429289.1 1684405 R 458234 CDS YP_001429290.1 156503225 5524458 complement(1685122..1685886) 1 NC_009749.1 major intrinsic protein family permease 1685886 5524458 FTA_1859 Francisella tularensis subsp. holarctica FTNF002-00 major intrinsic protein family permease YP_001429290.1 1685122 R 458234 CDS YP_001429291.1 156503226 5524459 complement(1685896..1687428) 1 NC_009749.1 FAD dependent oxidoreductase 1687428 5524459 FTA_1860 Francisella tularensis subsp. holarctica FTNF002-00 FAD dependent oxidoreductase YP_001429291.1 1685896 R 458234 CDS YP_001429292.2 169656751 5524460 join(1687744..1688073,1688073..1688624) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1688624 5524460 FTA_1861 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429292.2 1687744 D 458234 CDS YP_001429299.1 156503235 5522772 1691627..1693054 1 NC_009749.1 histidine kinase domain-containing protein 1693054 5522772 FTA_1869 Francisella tularensis subsp. holarctica FTNF002-00 histidine kinase domain-containing protein YP_001429299.1 1691627 D 458234 CDS YP_001429300.1 156503234 5522774 complement(1693051..1693932) 1 NC_009749.1 hypothetical protein 1693932 5522774 FTA_1868 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429300.1 1693051 R 458234 CDS YP_001429301.2 169656752 5522773 1694450..1695544 1 NC_009749.1 cytochrome ubiquinol oxidase 1695544 5522773 FTA_1870 Francisella tularensis subsp. holarctica FTNF002-00 cytochrome ubiquinol oxidase YP_001429301.2 1694450 D 458234 CDS YP_001429302.1 156503237 5522775 1695548..1696510 1 NC_009749.1 cytochrome bd-type quinol oxidase subunit II 1696510 5522775 FTA_1871 Francisella tularensis subsp. holarctica FTNF002-00 cytochrome bd-type quinol oxidase subunit II YP_001429302.1 1695548 D 458234 CDS YP_001429303.1 156503238 5522776 1696521..1696955 1 NC_009749.1 hypothetical protein 1696955 5522776 FTA_1872 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429303.1 1696521 D 458234 CDS YP_001429309.1 156503244 5522782 complement(1699152..1701965) 1 NC_009749.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1701965 acnA 5522782 acnA Francisella tularensis subsp. holarctica FTNF002-00 aconitate hydratase YP_001429309.1 1699152 R 458234 CDS YP_001429310.1 156503245 5522783 complement(1702070..1702948) 1 NC_009749.1 hypothetical protein 1702948 5522783 FTA_1879 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429310.1 1702070 R 458234 CDS YP_001429311.1 156503246 5522784 1703018..1703395 1 NC_009749.1 hypothetical protein 1703395 5522784 FTA_1880 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429311.1 1703018 D 458234 CDS YP_001429312.2 169656754 5522785 1703400..1704542 1 NC_009749.1 oxygen-independent coproporphyrinogen III oxidase 1704542 5522785 FTA_1882 Francisella tularensis subsp. holarctica FTNF002-00 oxygen-independent coproporphyrinogen III oxidase YP_001429312.2 1703400 D 458234 CDS YP_001429313.2 169656753 5524349 complement(1704539..1705015) 1 NC_009749.1 hypothetical protein 1705015 5524349 FTA_1881 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429313.2 1704539 R 458234 CDS YP_001429316.1 156503251 5524401 complement(1706221..1706574) 1 NC_009749.1 preprotein translocase subunit SecG 1706574 secG 5524401 secG Francisella tularensis subsp. holarctica FTNF002-00 preprotein translocase subunit SecG YP_001429316.1 1706221 R 458234 CDS YP_001429317.2 169656755 5524352 complement(1706562..1707323) 1 NC_009749.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1707323 tpiA 5524352 tpiA Francisella tularensis subsp. holarctica FTNF002-00 triosephosphate isomerase YP_001429317.2 1706562 R 458234 CDS YP_001429318.1 156503253 5524353 complement(1707326..1708657) 1 NC_009749.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1708657 glmM 5524353 glmM Francisella tularensis subsp. holarctica FTNF002-00 phosphoglucosamine mutase YP_001429318.1 1707326 R 458234 CDS YP_001429319.1 156503254 5524354 complement(1708668..1709195) 1 NC_009749.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1709195 apt 5524354 apt Francisella tularensis subsp. holarctica FTNF002-00 adenine phosphoribosyltransferase YP_001429319.1 1708668 R 458234 CDS YP_001429320.2 169656756 5524355 complement(1709235..1710704) 1 NC_009749.1 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase 1710704 sucB 5524355 sucB Francisella tularensis subsp. holarctica FTNF002-00 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase YP_001429320.2 1709235 R 458234 CDS YP_001429321.1 156503256 5524356 complement(1710730..1713555) 1 NC_009749.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 1713555 sucA 5524356 sucA Francisella tularensis subsp. holarctica FTNF002-00 2-oxoglutarate dehydrogenase E1 component YP_001429321.1 1710730 R 458234 CDS YP_001429322.1 156503257 5524357 complement(1713573..1714274) 1 NC_009749.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 1714274 sdhB 5524357 sdhB Francisella tularensis subsp. holarctica FTNF002-00 succinate dehydrogenase iron-sulfur subunit YP_001429322.1 1713573 R 458234 CDS YP_001429323.1 156503258 5524358 complement(1714292..1716085) 1 NC_009749.1 succinate dehydrogenase, flavoprotein subunit 1716085 sdhA 5524358 sdhA Francisella tularensis subsp. holarctica FTNF002-00 succinate dehydrogenase, flavoprotein subunit YP_001429323.1 1714292 R 458234 CDS YP_001429324.2 169656757 5524359 complement(1716098..1716466) 1 NC_009749.1 hypothetical protein 1716466 5524359 FTA_1893 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429324.2 1716098 R 458234 CDS YP_001429325.2 169656758 5524360 complement(1716442..1716915) 1 NC_009749.1 succinate dehydrogenase, cytochrome b subunit 1716915 5524360 FTA_1894 Francisella tularensis subsp. holarctica FTNF002-00 succinate dehydrogenase, cytochrome b subunit YP_001429325.2 1716442 R 458234 CDS YP_001429326.2 169656759 5524361 1717158..1718432 1 NC_009749.1 citrate synthase I 1718432 gltA 5524361 gltA Francisella tularensis subsp. holarctica FTNF002-00 citrate synthase I YP_001429326.2 1717158 D 458234 CDS YP_001429327.1 156503262 5524362 1718521..1719786 1 NC_009749.1 major facilitator transporter 1719786 5524362 FTA_1896 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001429327.1 1718521 D 458234 CDS YP_001429328.1 156503263 5524363 complement(1719791..1719925) 1 NC_009749.1 hypothetical protein 1719925 5524363 FTA_1897 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429328.1 1719791 R 458234 CDS YP_001429329.1 156503264 5522786 complement(1719991..1720569) 1 NC_009749.1 Fe/Mn family superoxide dismutase 1720569 5522786 FTA_1898 Francisella tularensis subsp. holarctica FTNF002-00 Fe/Mn family superoxide dismutase YP_001429329.1 1719991 R 458234 CDS YP_001429330.1 156503265 5522787 1720705..1721034 1 NC_009749.1 glutaredoxin-like protein 1721034 5522787 FTA_1899 Francisella tularensis subsp. holarctica FTNF002-00 glutaredoxin-like protein YP_001429330.1 1720705 D 458234 CDS YP_001429331.2 169656760 5522788 complement(1721051..1723894) 1 NC_009749.1 hypothetical protein 1723894 5522788 FTA_1900 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429331.2 1721051 R 458234 CDS YP_001429332.1 156503267 5522789 complement(1724105..1724542) 1 NC_009749.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit epsilon 1724542 atpC 5522789 atpC Francisella tularensis subsp. holarctica FTNF002-00 F0F1 ATP synthase subunit epsilon YP_001429332.1 1724105 R 458234 CDS YP_001429333.1 156503268 5522790 complement(1724555..1725931) 1 NC_009749.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 1725931 atpD 5522790 atpD Francisella tularensis subsp. holarctica FTNF002-00 F0F1 ATP synthase subunit beta YP_001429333.1 1724555 R 458234 CDS YP_001429334.2 169656761 5522791 complement(1725941..1726837) 1 NC_009749.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 1726837 atpG 5522791 atpG Francisella tularensis subsp. holarctica FTNF002-00 F0F1 ATP synthase subunit gamma YP_001429334.2 1725941 R 458234 CDS YP_001429335.1 156503270 5522792 complement(1726852..1728393) 1 NC_009749.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 1728393 atpA 5522792 atpA Francisella tularensis subsp. holarctica FTNF002-00 F0F1 ATP synthase subunit alpha YP_001429335.1 1726852 R 458234 CDS YP_001429336.1 156503271 5522793 complement(1728412..1728936) 1 NC_009749.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 1728936 atpH 5522793 atpH Francisella tularensis subsp. holarctica FTNF002-00 F0F1 ATP synthase subunit delta YP_001429336.1 1728412 R 458234 CDS YP_001429337.1 156503272 5522794 complement(1728956..1729426) 1 NC_009749.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 1729426 atpF 5522794 atpF Francisella tularensis subsp. holarctica FTNF002-00 F0F1 ATP synthase subunit B YP_001429337.1 1728956 R 458234 CDS YP_001429338.1 156503273 5522795 complement(1729472..1729777) 1 NC_009749.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 1729777 atpE 5522795 atpE Francisella tularensis subsp. holarctica FTNF002-00 F0F1 ATP synthase subunit C YP_001429338.1 1729472 R 458234 CDS YP_001429339.1 156503274 5522796 complement(1729828..1730619) 1 NC_009749.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 1730619 atpB 5522796 atpB Francisella tularensis subsp. holarctica FTNF002-00 F0F1 ATP synthase subunit A YP_001429339.1 1729828 R 458234 CDS YP_001429340.2 169656762 5522797 complement(1730672..1731103) 1 NC_009749.1 hypothetical protein 1731103 5522797 FTA_1909 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429340.2 1730672 R 458234 CDS YP_001429341.2 169656763 5522798 1731180..1732484 1 NC_009749.1 major facilitator transporter 1732484 5522798 FTA_1910 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001429341.2 1731180 D 458234 CDS YP_001429342.1 156503277 5522799 complement(1732486..1733415) 1 NC_009749.1 ribosomal large subunit pseudouridine synthase C 1733415 5522799 FTA_1911 Francisella tularensis subsp. holarctica FTNF002-00 ribosomal large subunit pseudouridine synthase C YP_001429342.1 1732486 R 458234 CDS YP_001429343.1 156503278 5522800 complement(1733408..1734475) 1 NC_009749.1 AFG1 family ATPase 1734475 5522800 FTA_1912 Francisella tularensis subsp. holarctica FTNF002-00 AFG1 family ATPase YP_001429343.1 1733408 R 458234 CDS YP_001429344.1 156503279 5522801 complement(1734478..1735776) 1 NC_009749.1 major facilitator transporter 1735776 5522801 FTA_1913 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001429344.1 1734478 R 458234 CDS YP_001429345.1 156503280 5523874 complement(1735783..1737048) 1 NC_009749.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 1737048 hisS 5523874 hisS Francisella tularensis subsp. holarctica FTNF002-00 histidyl-tRNA synthetase YP_001429345.1 1735783 R 458234 CDS YP_001429346.1 156503281 5523875 complement(1737056..1737487) 1 NC_009749.1 ribosome-binding factor A 1737487 rbfA 5523875 rbfA Francisella tularensis subsp. holarctica FTNF002-00 ribosome-binding factor A YP_001429346.1 1737056 R 458234 CDS YP_001429347.1 156503282 5523876 complement(1737490..1740030) 1 NC_009749.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1740030 infB 5523876 infB Francisella tularensis subsp. holarctica FTNF002-00 translation initiation factor IF-2 YP_001429347.1 1737490 R 458234 CDS YP_001429348.1 156503283 5523877 complement(1740069..1741538) 1 NC_009749.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 1741538 nusA 5523877 nusA Francisella tularensis subsp. holarctica FTNF002-00 transcription elongation factor NusA YP_001429348.1 1740069 R 458234 CDS YP_001429349.2 169656764 5523878 complement(1741556..1742014) 1 NC_009749.1 hypothetical protein 1742014 5523878 FTA_1918 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429349.2 1741556 R 458234 CDS YP_001429350.1 156503285 5524220 complement(1742234..1743268) 1 NC_009749.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 1743268 hemE 5524220 hemE Francisella tularensis subsp. holarctica FTNF002-00 uroporphyrinogen decarboxylase YP_001429350.1 1742234 R 458234 CDS YP_001429353.2 169656765 5523882 complement(join(1744760..1745311,1745311..1745640)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1745640 5523882 FTA_1922 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429353.2 1744760 R 458234 CDS YP_001429355.1 156503290 5523884 complement(1745781..1745975) 1 NC_009749.1 hypothetical protein 1745975 5523884 FTA_1924 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429355.1 1745781 R 458234 CDS YP_001429356.2 169656766 5523885 complement(1746051..1747508) 1 NC_009749.1 NADH-quinone oxidoreductase subunit N 1747508 5523885 FTA_1925 Francisella tularensis subsp. holarctica FTNF002-00 NADH-quinone oxidoreductase subunit N YP_001429356.2 1746051 R 458234 CDS YP_001429357.1 156503292 5523886 complement(1747518..1749107) 1 NC_009749.1 NADH dehydrogenase I subunit M 1749107 nuoM 5523886 nuoM Francisella tularensis subsp. holarctica FTNF002-00 NADH dehydrogenase I subunit M YP_001429357.1 1747518 R 458234 CDS YP_001429358.1 156503293 5523887 complement(1749133..1751142) 1 NC_009749.1 NADH dehydrogenase I subunit L 1751142 nuoL 5523887 nuoL Francisella tularensis subsp. holarctica FTNF002-00 NADH dehydrogenase I subunit L YP_001429358.1 1749133 R 458234 CDS YP_001429359.2 169656767 5523888 complement(1751152..1751484) 1 NC_009749.1 Sequence similarity to NADH dehydrogenase I subunit K (nuoK); NADH-ubiquinone oxidoreductase, chain 4L 1751484 5523888 FTA_1928 Francisella tularensis subsp. holarctica FTNF002-00 NADH-ubiquinone oxidoreductase, chain 4L YP_001429359.2 1751152 R 458234 CDS YP_001429360.1 156503295 5523889 complement(1751462..1752067) 1 NC_009749.1 sequence similarity to NADH dehydrogenase I subunit J (nuoJ); NADH dehydrogenase I subunit J 1752067 5523889 FTA_1929 Francisella tularensis subsp. holarctica FTNF002-00 NADH dehydrogenase I subunit J YP_001429360.1 1751462 R 458234 CDS YP_001429361.1 156503296 5524306 complement(1752072..1752560) 1 NC_009749.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 1752560 5524306 FTA_1930 Francisella tularensis subsp. holarctica FTNF002-00 NADH dehydrogenase subunit I YP_001429361.1 1752072 R 458234 CDS YP_001429362.1 156503297 5524307 complement(1752574..1753584) 1 NC_009749.1 Shows high %identity to NADH dehydrogenase I subunit H (nuoH), hence named based on sequence similarity using Blast; NADH dehydrogenase I subunit H 1753584 5524307 FTA_1931 Francisella tularensis subsp. holarctica FTNF002-00 NADH dehydrogenase I subunit H YP_001429362.1 1752574 R 458234 CDS YP_001429363.1 156503298 5524308 complement(1753586..1755952) 1 NC_009749.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit G 1755952 nuoG 5524308 nuoG Francisella tularensis subsp. holarctica FTNF002-00 NADH dehydrogenase subunit G YP_001429363.1 1753586 R 458234 CDS YP_001429364.2 169656768 5524309 complement(1755970..1757244) 1 NC_009749.1 NADH dehydrogenase I subunit F 1757244 nuoF 5524309 nuoF Francisella tularensis subsp. holarctica FTNF002-00 NADH dehydrogenase I subunit F YP_001429364.2 1755970 R 458234 CDS YP_001429365.1 156503300 5524310 complement(1757251..1757739) 1 NC_009749.1 NADH dehydrogenase I subunit E 1757739 nuoE 5524310 nuoE Francisella tularensis subsp. holarctica FTNF002-00 NADH dehydrogenase I subunit E YP_001429365.1 1757251 R 458234 CDS YP_001429366.1 156503301 5524311 complement(1757749..1759002) 1 NC_009749.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 1759002 nuoD 5524311 nuoD Francisella tularensis subsp. holarctica FTNF002-00 NADH dehydrogenase subunit D YP_001429366.1 1757749 R 458234 CDS YP_001429367.2 169656769 5524312 complement(1759024..1759674) 1 NC_009749.1 NADH dehydrogenase I subunit C 1759674 nuoC 5524312 nuoC Francisella tularensis subsp. holarctica FTNF002-00 NADH dehydrogenase I subunit C YP_001429367.2 1759024 R 458234 CDS YP_001429368.1 156503303 5524313 complement(1759671..1760147) 1 NC_009749.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 1760147 nuoB 5524313 nuoB Francisella tularensis subsp. holarctica FTNF002-00 NADH dehydrogenase subunit B YP_001429368.1 1759671 R 458234 CDS YP_001429369.1 156503304 5524314 complement(1760138..1760536) 1 NC_009749.1 Named NADH dehydrogenase I subunit A (nuoA) because of high sequence similarity by Blast; NADH dehydrogenase I subunit A 1760536 nuoA 5524314 nuoA Francisella tularensis subsp. holarctica FTNF002-00 NADH dehydrogenase I subunit A YP_001429369.1 1760138 R 458234 CDS YP_001429370.1 156503305 5524315 1760745..1761167 1 NC_009749.1 ferric uptake regulation protein 1761167 5524315 FTA_1939 Francisella tularensis subsp. holarctica FTNF002-00 ferric uptake regulation protein YP_001429370.1 1760745 D 458234 CDS YP_001429371.1 156503306 5524316 1761421..1763340 1 NC_009749.1 IucA/IucC family siderophore biosynthesis protein 1763340 5524316 FTA_1940 Francisella tularensis subsp. holarctica FTNF002-00 IucA/IucC family siderophore biosynthesis protein YP_001429371.1 1761421 D 458234 CDS YP_001429372.2 169656770 5524317 1763347..1764609 1 NC_009749.1 major facilitator transporter 1764609 5524317 FTA_1941 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001429372.2 1763347 D 458234 CDS YP_001429373.1 156503308 5524318 1764602..1765855 1 NC_009749.1 diaminopimelate decarboxylase 1765855 5524318 FTA_1942 Francisella tularensis subsp. holarctica FTNF002-00 diaminopimelate decarboxylase YP_001429373.1 1764602 D 458234 CDS YP_001429374.1 156503309 5524319 1765871..1767061 1 NC_009749.1 major facilitator transporter 1767061 5524319 FTA_1943 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001429374.1 1765871 D 458234 CDS YP_001429375.1 156503310 5524320 1767147..1768676 1 NC_009749.1 hypothetical protein 1768676 5524320 FTA_1944 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429375.1 1767147 D 458234 CDS YP_001429378.2 169656771 5523360 complement(1770232..1770639) 1 NC_009749.1 hypothetical protein 1770639 5523360 FTA_1947 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429378.2 1770232 R 458234 CDS YP_001429379.2 169656772 5523361 complement(1770654..1772075) 1 NC_009749.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 1772075 gatB 5523361 gatB Francisella tularensis subsp. holarctica FTNF002-00 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_001429379.2 1770654 R 458234 CDS YP_001429380.1 156503315 5523362 complement(1772078..1773523) 1 NC_009749.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 1773523 gatA 5523362 gatA Francisella tularensis subsp. holarctica FTNF002-00 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_001429380.1 1772078 R 458234 CDS YP_001429381.1 156503316 5523363 complement(1773532..1773813) 1 NC_009749.1 Glu-tRNAGln amidotransferase subunit C 1773813 gatC 5523363 gatC Francisella tularensis subsp. holarctica FTNF002-00 Glu-tRNAGln amidotransferase subunit C YP_001429381.1 1773532 R 458234 CDS YP_001429386.1 156503321 5523368 complement(1776600..1777178) 1 NC_009749.1 hypothetical protein 1777178 5523368 FTA_1955 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429386.1 1776600 R 458234 CDS YP_001429387.1 156503322 5523369 complement(1777212..1778510) 1 NC_009749.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1778510 purB 5523369 purB Francisella tularensis subsp. holarctica FTNF002-00 adenylosuccinate lyase YP_001429387.1 1777212 R 458234 CDS YP_001429388.1 156503323 5523370 complement(1778683..1779339) 1 NC_009749.1 transposase ISFTu2 1779339 5523370 FTA_1957 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001429388.1 1778683 R 458234 CDS YP_001429391.2 169656773 5523373 complement(1781136..1781996) 1 NC_009749.1 aldose 1-epimerase family protein 1781996 5523373 FTA_1960 Francisella tularensis subsp. holarctica FTNF002-00 aldose 1-epimerase family protein YP_001429391.2 1781136 R 458234 CDS YP_001429392.1 156503327 5523374 complement(1782281..1782895) 1 NC_009749.1 hypothetical protein 1782895 5523374 FTA_1961 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429392.1 1782281 R 458234 CDS YP_001429397.1 156503332 5524177 complement(1784113..1787985) 1 NC_009749.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 1787985 purL 5524177 purL Francisella tularensis subsp. holarctica FTNF002-00 phosphoribosylformylglycinamidine synthase YP_001429397.1 1784113 R 458234 CDS YP_001429398.1 156503333 5524178 complement(1787985..1789475) 1 NC_009749.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 1789475 purF 5524178 purF Francisella tularensis subsp. holarctica FTNF002-00 amidophosphoribosyltransferase YP_001429398.1 1787985 R 458234 CDS YP_001429402.2 169656774 5524182 complement(1790883..1791527) 1 NC_009749.1 4'-phosphopantetheinyl transferase 1791527 5524182 FTA_1971 Francisella tularensis subsp. holarctica FTNF002-00 4'-phosphopantetheinyl transferase YP_001429402.2 1790883 R 458234 CDS YP_001429403.1 156503338 5524183 complement(1791533..1793062) 1 NC_009749.1 TolC family outer membrane efflux protein 1793062 5524183 FTA_1972 Francisella tularensis subsp. holarctica FTNF002-00 TolC family outer membrane efflux protein YP_001429403.1 1791533 R 458234 CDS YP_001429404.1 156503339 5524184 complement(1793071..1793691) 1 NC_009749.1 protein-L-isoaspartate(D-aspartate) O-methyltransferase 1793691 5524184 FTA_1973 Francisella tularensis subsp. holarctica FTNF002-00 protein-L-isoaspartate(D-aspartate) O-methyltransferase YP_001429404.1 1793071 R 458234 CDS YP_001429405.1 156503340 5524185 1794011..1795342 1 NC_009749.1 peptidase U32 family protein 1795342 5524185 FTA_1974 Francisella tularensis subsp. holarctica FTNF002-00 peptidase U32 family protein YP_001429405.1 1794011 D 458234 CDS YP_001429406.2 169656775 5524186 complement(1795382..1796572) 1 NC_009749.1 major facilitator superfamily multidrug resistance protein 1796572 5524186 FTA_1975 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator superfamily multidrug resistance protein YP_001429406.2 1795382 R 458234 CDS YP_001429407.1 156503342 5524187 1796738..1798165 1 NC_009749.1 Na+/H+ antiporter 1798165 5524187 FTA_1976 Francisella tularensis subsp. holarctica FTNF002-00 Na+/H+ antiporter YP_001429407.1 1796738 D 458234 CDS YP_001429411.1 156503346 5523804 complement(1799805..1801679) 1 NC_009749.1 amino acid transporter 1801679 5523804 FTA_1980 Francisella tularensis subsp. holarctica FTNF002-00 amino acid transporter YP_001429411.1 1799805 R 458234 CDS YP_001429412.1 156503347 5523805 complement(1801686..1802690) 1 NC_009749.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1802690 obgE 5523805 obgE Francisella tularensis subsp. holarctica FTNF002-00 GTPase ObgE YP_001429412.1 1801686 R 458234 CDS YP_001429413.1 156503348 5523806 complement(1802766..1803962) 1 NC_009749.1 tryptophan/tyrosine permease family protein 1803962 5523806 FTA_1982 Francisella tularensis subsp. holarctica FTNF002-00 tryptophan/tyrosine permease family protein YP_001429413.1 1802766 R 458234 CDS YP_001429416.1 156503351 5523809 complement(1805259..1805630) 1 NC_009749.1 N-terminal truncated; transcriptional regulator 1805630 5523809 FTA_1985 Francisella tularensis subsp. holarctica FTNF002-00 transcriptional regulator YP_001429416.1 1805259 R 458234 CDS YP_001429420.1 156503355 5523813 complement(1808760..1809314) 1 NC_009749.1 potassium-transporting ATPase C chain 1809314 kdpC 5523813 kdpC Francisella tularensis subsp. holarctica FTNF002-00 potassium-transporting ATPase C chain YP_001429420.1 1808760 R 458234 CDS YP_001429423.1 156503358 5523816 complement(1811318..1813039) 1 NC_009749.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 1813039 kdpA 5523816 kdpA Francisella tularensis subsp. holarctica FTNF002-00 potassium-transporting ATPase subunit A YP_001429423.1 1811318 R 458234 CDS YP_001429425.1 156503360 5522802 complement(1813515..1814330) 1 NC_009749.1 transposase ISFTu2 1814330 5522802 FTA_1994 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001429425.1 1813515 R 458234 CDS YP_001429426.2 169656776 5522803 complement(join(1814521..1815021,1815021..1815350)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1815350 5522803 FTA_1995 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429426.2 1814521 R 458234 CDS YP_001429429.1 156503364 5522806 complement(1816588..1817157) 1 NC_009749.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 1817157 leuD 5522806 leuD Francisella tularensis subsp. holarctica FTNF002-00 isopropylmalate isomerase small subunit YP_001429429.1 1816588 R 458234 CDS YP_001429430.1 156503365 5522807 complement(1817160..1818563) 1 NC_009749.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 1818563 leuC 5522807 leuC Francisella tularensis subsp. holarctica FTNF002-00 isopropylmalate isomerase large subunit YP_001429430.1 1817160 R 458234 CDS YP_001429431.2 169656777 5522808 join(1818857..1819186,1819186..1819686) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1819686 5522808 FTA_2000 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429431.2 1818857 D 458234 CDS YP_001429433.1 156503368 5522810 1819877..1820557 1 NC_009749.1 transposase ISFTu2 1820557 5522810 FTA_2002 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001429433.1 1819877 D 458234 CDS YP_001429435.1 156503370 5522812 complement(1822621..1823139) 1 NC_009749.1 lipocalin-like domain-containing lipoprotein 1823139 5522812 FTA_2004 Francisella tularensis subsp. holarctica FTNF002-00 lipocalin-like domain-containing lipoprotein YP_001429435.1 1822621 R 458234 CDS YP_001429436.1 156503371 5522813 1823225..1824202 1 NC_009749.1 DNA polymerase III subunit delta 1824202 holA 5522813 holA Francisella tularensis subsp. holarctica FTNF002-00 DNA polymerase III subunit delta YP_001429436.1 1823225 D 458234 CDS YP_001429437.1 156503372 5522814 1824322..1825359 1 NC_009749.1 glutamine synthetase 1825359 glnA 5522814 glnA Francisella tularensis subsp. holarctica FTNF002-00 glutamine synthetase YP_001429437.1 1824322 D 458234 CDS YP_001429438.2 169656778 5522815 1825441..1826982 1 NC_009749.1 glutaminase 1826982 5522815 FTA_2007 Francisella tularensis subsp. holarctica FTNF002-00 glutaminase YP_001429438.2 1825441 D 458234 CDS YP_001429440.1 156503375 5522817 1827976..1828518 1 NC_009749.1 hypothetical protein 1828518 5522817 FTA_2009 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429440.1 1827976 D 458234 CDS YP_001429441.1 156503376 5524478 complement(1828903..1830633) 1 NC_009749.1 lysyl-tRNA synthetase 1830633 lysS 5524478 lysS Francisella tularensis subsp. holarctica FTNF002-00 lysyl-tRNA synthetase YP_001429441.1 1828903 R 458234 CDS YP_001429442.1 156503377 5524479 complement(1830763..1831740) 1 NC_009749.1 peptide chain release factor 2 1831740 prfB 5524479 prfB Francisella tularensis subsp. holarctica FTNF002-00 peptide chain release factor 2 YP_001429442.1 1830763 R 458234 CDS YP_001429443.1 156503378 5524480 1832013..1833650 1 NC_009749.1 DNA polymerase III subunits gamma/tau 1833650 dnaX 5524480 dnaX Francisella tularensis subsp. holarctica FTNF002-00 DNA polymerase III subunits gamma/tau YP_001429443.1 1832013 D 458234 CDS YP_001429444.1 156503379 5524481 complement(1833664..1834524) 1 NC_009749.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 1834524 lpxC 5524481 lpxC Francisella tularensis subsp. holarctica FTNF002-00 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_001429444.1 1833664 R 458234 CDS YP_001429445.1 156503380 5524482 complement(1834547..1835692) 1 NC_009749.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1835692 ftsZ 5524482 ftsZ Francisella tularensis subsp. holarctica FTNF002-00 cell division protein FtsZ YP_001429445.1 1834547 R 458234 CDS YP_001429446.1 156503381 5524483 complement(1835736..1836998) 1 NC_009749.1 cell division protein FtsA 1836998 ftsA 5524483 ftsA Francisella tularensis subsp. holarctica FTNF002-00 cell division protein FtsA YP_001429446.1 1835736 R 458234 CDS YP_001429447.1 156503382 5524484 complement(1837100..1837783) 1 NC_009749.1 cell division protein FtsQ 1837783 5524484 FTA_2016 Francisella tularensis subsp. holarctica FTNF002-00 cell division protein FtsQ YP_001429447.1 1837100 R 458234 CDS YP_001429448.1 156503383 5524485 complement(1837780..1838670) 1 NC_009749.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 1838670 5524485 FTA_2017 Francisella tularensis subsp. holarctica FTNF002-00 D-alanyl-alanine synthetase A YP_001429448.1 1837780 R 458234 CDS YP_001429449.1 156503384 5524486 complement(1838674..1839135) 1 NC_009749.1 cytidine/deoxycytidylate deaminase zinc-binding domain-containing protein 1839135 5524486 FTA_2018 Francisella tularensis subsp. holarctica FTNF002-00 cytidine/deoxycytidylate deaminase zinc-binding domain-containing protein YP_001429449.1 1838674 R 458234 CDS YP_001429450.2 169656779 5524487 1839229..1840953 1 NC_009749.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1840953 rpsA 5524487 rpsA Francisella tularensis subsp. holarctica FTNF002-00 30S ribosomal protein S1 YP_001429450.2 1839229 D 458234 CDS YP_001429451.1 156503386 5524488 1841070..1841612 1 NC_009749.1 YrdC domain-containing protein 1841612 5524488 FTA_2020 Francisella tularensis subsp. holarctica FTNF002-00 YrdC domain-containing protein YP_001429451.1 1841070 D 458234 CDS YP_001429452.1 156503387 5524489 1841710..1842246 1 NC_009749.1 hypothetical protein 1842246 5524489 FTA_2021 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429452.1 1841710 D 458234 CDS YP_001429453.2 169656780 5524490 complement(1842632..1843522) 1 NC_009749.1 putative acyltransferase 1843522 5524490 FTA_2022 Francisella tularensis subsp. holarctica FTNF002-00 putative acyltransferase YP_001429453.2 1842632 R 458234 CDS YP_001429454.1 156503389 5524491 1843332..1843496 1 NC_009749.1 hypothetical protein 1843496 5524491 FTA_2023 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429454.1 1843332 D 458234 CDS YP_001429455.1 156503390 5524492 complement(1843623..1845638) 1 NC_009749.1 ComEC/Rec2-related competence protein 1845638 5524492 FTA_2024 Francisella tularensis subsp. holarctica FTNF002-00 ComEC/Rec2-related competence protein YP_001429455.1 1843623 R 458234 CDS YP_001429460.1 156503396 5523189 1849207..1849989 1 NC_009749.1 ABC transporter ATP-binding protein 1849989 5523189 FTA_2030 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter ATP-binding protein YP_001429460.1 1849207 D 458234 CDS YP_001429461.1 156503395 5523191 complement(1849983..1850552) 1 NC_009749.1 YGGT family membrane protein 1850552 5523191 FTA_2029 Francisella tularensis subsp. holarctica FTNF002-00 YGGT family membrane protein YP_001429461.1 1849983 R 458234 CDS YP_001429462.1 156503397 5523190 complement(1850667..1851482) 1 NC_009749.1 hypothetical protein 1851482 5523190 FTA_2031 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429462.1 1850667 R 458234 CDS YP_001429463.2 169656781 5523192 complement(1851552..1851962) 1 NC_009749.1 hypothetical protein 1851962 5523192 FTA_2032 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429463.2 1851552 R 458234 CDS YP_001429464.2 169656782 5523193 complement(join(1851907..1852458,1852458..1852787)) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1852787 5523193 FTA_2033 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429464.2 1851907 R 458234 CDS YP_001429466.1 156503401 5523195 complement(1852849..1853334) 1 NC_009749.1 transposase ISFTu2 1853334 5523195 FTA_2035 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFTu2 YP_001429466.1 1852849 R 458234 CDS YP_001429469.1 156503404 5523198 complement(1854705..1856252) 1 NC_009749.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1856252 purH 5523198 purH Francisella tularensis subsp. holarctica FTNF002-00 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_001429469.1 1854705 R 458234 CDS YP_001429470.1 156503405 5523199 1856429..1857715 1 NC_009749.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 1857715 purA 5523199 purA Francisella tularensis subsp. holarctica FTNF002-00 adenylosuccinate synthetase YP_001429470.1 1856429 D 458234 CDS YP_001429471.1 156503406 5523200 1857719..1858252 1 NC_009749.1 hypoxanthine-guanine phosphoribosyltransferase 1858252 hpt 5523200 hpt Francisella tularensis subsp. holarctica FTNF002-00 hypoxanthine-guanine phosphoribosyltransferase YP_001429471.1 1857719 D 458234 CDS YP_001429474.2 169656783 5523390 complement(1859082..1859945) 1 NC_009749.1 ABC 3 transporter family protein 1859945 5523390 FTA_2043 Francisella tularensis subsp. holarctica FTNF002-00 ABC 3 transporter family protein YP_001429474.2 1859082 R 458234 CDS YP_001429475.2 169656784 5523391 complement(1859866..1860594) 1 NC_009749.1 ABC transporter ATP-binding protein 1860594 5523391 FTA_2044 Francisella tularensis subsp. holarctica FTNF002-00 ABC transporter ATP-binding protein YP_001429475.2 1859866 R 458234 CDS YP_001429476.1 156503411 5523392 complement(1860545..1861462) 1 NC_009749.1 periplasmic solute binding family protein 1861462 5523392 FTA_2045 Francisella tularensis subsp. holarctica FTNF002-00 periplasmic solute binding family protein YP_001429476.1 1860545 R 458234 CDS YP_001429480.1 156503415 5523396 complement(1862872..1863336) 1 NC_009749.1 outer membrane lipoprotein 1863336 5523396 FTA_2049 Francisella tularensis subsp. holarctica FTNF002-00 outer membrane lipoprotein YP_001429480.1 1862872 R 458234 CDS YP_001429481.1 156503416 5523397 complement(1863347..1863943) 1 NC_009749.1 flavodoxin domain-containing protein 1863943 5523397 FTA_2050 Francisella tularensis subsp. holarctica FTNF002-00 flavodoxin domain-containing protein YP_001429481.1 1863347 R 458234 CDS YP_001429482.1 156503417 5523398 1863950..1865137 1 NC_009749.1 YihY family membrane protein 1865137 5523398 FTA_2051 Francisella tularensis subsp. holarctica FTNF002-00 YihY family membrane protein YP_001429482.1 1863950 D 458234 CDS YP_001429483.1 156503418 5523399 1865156..1865731 1 NC_009749.1 nicotinamide mononucleotide transporter, PnuC family protein 1865731 5523399 FTA_2052 Francisella tularensis subsp. holarctica FTNF002-00 nicotinamide mononucleotide transporter, PnuC family protein YP_001429483.1 1865156 D 458234 CDS YP_001429484.1 156503419 5523400 1865728..1867881 1 NC_009749.1 primosomal protein N' 1867881 priA 5523400 priA Francisella tularensis subsp. holarctica FTNF002-00 primosomal protein N' YP_001429484.1 1865728 D 458234 CDS YP_001429485.2 169656785 5523401 join(1868027..1868356,1868356..1868907) 1 NC_009749.1 programmed ribosomal frameshift; transposase ISFtu1 1868907 5523401 FTA_2054 Francisella tularensis subsp. holarctica FTNF002-00 transposase ISFtu1 YP_001429485.2 1868027 D 458234 CDS YP_001429488.1 156503423 5523404 complement(1869742..1871421) 1 NC_009749.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 1871421 5523404 FTA_2057 Francisella tularensis subsp. holarctica FTNF002-00 putative ABC transporter ATP-binding protein YP_001429488.1 1869742 R 458234 CDS YP_001429489.2 169656786 5524636 1871589..1872866 1 NC_009749.1 major facilitator transporter 1872866 5524636 FTA_2058 Francisella tularensis subsp. holarctica FTNF002-00 major facilitator transporter YP_001429489.2 1871589 D 458234 CDS YP_001429491.1 156503426 5524638 complement(1873173..1873385) 1 NC_009749.1 hypothetical protein 1873385 5524638 FTA_2060 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429491.1 1873173 R 458234 CDS YP_001429492.1 156503427 5524639 1873431..1874411 1 NC_009749.1 hypothetical protein 1874411 5524639 FTA_2061 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429492.1 1873431 D 458234 CDS YP_001429497.1 156503432 5524644 1876307..1876450 1 NC_009749.1 hypothetical protein 1876450 5524644 FTA_2066 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429497.1 1876307 D 458234 CDS YP_001429500.1 156503435 5524647 complement(1877350..1877829) 1 NC_009749.1 IS1016 family transposase 1877829 5524647 FTA_2069 Francisella tularensis subsp. holarctica FTNF002-00 IS1016 family transposase YP_001429500.1 1877350 R 458234 CDS YP_001429501.2 169656787 5524648 complement(1877902..1880496) 1 NC_009749.1 aminopeptidase N 1880496 pepN 5524648 pepN Francisella tularensis subsp. holarctica FTNF002-00 aminopeptidase N YP_001429501.2 1877902 R 458234 CDS YP_001429502.1 156503438 5524649 1880680..1881108 1 NC_009749.1 HSP20 family protein 1881108 5524649 FTA_2072 Francisella tularensis subsp. holarctica FTNF002-00 HSP20 family protein YP_001429502.1 1880680 D 458234 CDS YP_001429503.1 156503437 5524651 complement(1881105..1882466) 1 NC_009749.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1882466 trpCF 5524651 trpCF Francisella tularensis subsp. holarctica FTNF002-00 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_001429503.1 1881105 R 458234 CDS YP_001429504.1 156503439 5524650 complement(1882558..1882737) 1 NC_009749.1 N-terminal truncation; hypothetical protein 1882737 5524650 FTA_2073 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429504.1 1882558 R 458234 CDS YP_001429505.1 156503440 5524322 complement(1882976..1883665) 1 NC_009749.1 methionine-S-sulfoxide reductase 1883665 msrA 5524322 msrA Francisella tularensis subsp. holarctica FTNF002-00 methionine-S-sulfoxide reductase YP_001429505.1 1882976 R 458234 CDS YP_001429506.1 156503441 5524323 complement(1883749..1884117) 1 NC_009749.1 hypothetical protein 1884117 5524323 FTA_2075 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429506.1 1883749 R 458234 CDS YP_001429507.1 156503442 5524324 complement(1884110..1884451) 1 NC_009749.1 hypothetical protein 1884451 5524324 FTA_2076 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429507.1 1884110 R 458234 CDS YP_001429508.2 169656788 5524325 complement(1884520..1884960) 1 NC_009749.1 hypothetical protein 1884960 5524325 FTA_2077 Francisella tularensis subsp. holarctica FTNF002-00 hypothetical protein YP_001429508.2 1884520 R 458234 CDS YP_001429509.1 156503444 5524326 complement(1885022..1886047) 1 NC_009749.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1886047 trpD 5524326 trpD Francisella tularensis subsp. holarctica FTNF002-00 anthranilate phosphoribosyltransferase YP_001429509.1 1885022 R 458234 CDS YP_001429510.1 156503445 5524327 complement(1886032..1886610) 1 NC_009749.1 glutamine amidotransferase of anthranilate synthase/para-aminobenzoate synthase 1886610 5524327 FTA_2079 Francisella tularensis subsp. holarctica FTNF002-00 glutamine amidotransferase of anthranilate synthase/para-aminobenzoate synthase YP_001429510.1 1886032 R 458234 CDS YP_001429511.1 156503446 5524328 complement(1886614..1888158) 1 NC_009749.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1888158 trpE 5524328 trpE Francisella tularensis subsp. holarctica FTNF002-00 anthranilate synthase component I YP_001429511.1 1886614 R 458234 CDS YP_001429512.1 156503447 5524329 complement(1888167..1888454) 1 NC_009749.1 trp operon repressor 1888454 trpR 5524329 trpR Francisella tularensis subsp. holarctica FTNF002-00 trp operon repressor YP_001429512.1 1888167 R 458234 CDS YP_001429513.2 169656789 5524259 complement(1888928..1890424) 1 NC_009749.1 ribonuclease, Rne/Rng family protein 1890424 5524259 FTA_2082 Francisella tularensis subsp. holarctica FTNF002-00 ribonuclease, Rne/Rng family protein YP_001429513.2 1888928 R 458234 CDS