-- dump date   	20140619_095252
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
458234000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
458234000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
458234000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
458234000004	Walker A motif; other site
458234000005	ATP binding site [chemical binding]; other site
458234000006	Walker B motif; other site
458234000007	arginine finger; other site
458234000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
458234000009	DnaA box-binding interface [nucleotide binding]; other site
458234000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
458234000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
458234000012	putative DNA binding surface [nucleotide binding]; other site
458234000013	dimer interface [polypeptide binding]; other site
458234000014	beta-clamp/clamp loader binding surface; other site
458234000015	beta-clamp/translesion DNA polymerase binding surface; other site
458234000016	metabolite-proton symporter; Region: 2A0106; TIGR00883
458234000017	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000018	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000019	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000020	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000021	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
458234000022	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
458234000023	tandem repeat interface [polypeptide binding]; other site
458234000024	oligomer interface [polypeptide binding]; other site
458234000025	active site residues [active]
458234000026	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
458234000027	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
458234000028	preprotein translocase subunit SecB; Provisional; Region: PRK13031
458234000029	SecA binding site; other site
458234000030	Preprotein binding site; other site
458234000031	recombinase A; Provisional; Region: recA; PRK09354
458234000032	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
458234000033	hexamer interface [polypeptide binding]; other site
458234000034	Walker A motif; other site
458234000035	ATP binding site [chemical binding]; other site
458234000036	Walker B motif; other site
458234000037	recombination regulator RecX; Reviewed; Region: recX; PRK00117
458234000038	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
458234000039	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
458234000040	dimer interface [polypeptide binding]; other site
458234000041	ssDNA binding site [nucleotide binding]; other site
458234000042	tetramer (dimer of dimers) interface [polypeptide binding]; other site
458234000043	propionate/acetate kinase; Provisional; Region: PRK12379
458234000044	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
458234000045	phosphate acetyltransferase; Reviewed; Region: PRK05632
458234000046	DRTGG domain; Region: DRTGG; pfam07085
458234000047	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
458234000048	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000049	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000050	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000051	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000052	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
458234000053	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
458234000054	dimer interface [polypeptide binding]; other site
458234000055	anticodon binding site; other site
458234000056	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
458234000057	homodimer interface [polypeptide binding]; other site
458234000058	motif 1; other site
458234000059	active site
458234000060	motif 2; other site
458234000061	GAD domain; Region: GAD; pfam02938
458234000062	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
458234000063	active site
458234000064	motif 3; other site
458234000065	metabolite-proton symporter; Region: 2A0106; TIGR00883
458234000066	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000067	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000068	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000069	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000070	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
458234000071	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
458234000072	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
458234000073	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
458234000074	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
458234000075	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
458234000076	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
458234000077	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
458234000078	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
458234000079	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
458234000080	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
458234000081	ATP-grasp domain; Region: ATP-grasp_4; cl17255
458234000082	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
458234000083	substrate binding site [chemical binding]; other site
458234000084	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
458234000085	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
458234000086	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
458234000087	catalytic site [active]
458234000088	subunit interface [polypeptide binding]; other site
458234000089	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
458234000090	catalytic core [active]
458234000091	thiopurine S-methyltransferase; Reviewed; Region: PRK13256
458234000092	dihydroorotase; Reviewed; Region: PRK09236
458234000093	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
458234000094	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
458234000095	active site
458234000096	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
458234000097	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
458234000098	HlyD family secretion protein; Region: HlyD; pfam00529
458234000099	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
458234000100	HlyD family secretion protein; Region: HlyD_3; pfam13437
458234000101	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
458234000102	Transcriptional regulator [Transcription]; Region: LysR; COG0583
458234000103	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
458234000104	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
458234000105	dimerization interface [polypeptide binding]; other site
458234000106	SOUL heme-binding protein; Region: SOUL; pfam04832
458234000107	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234000108	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234000109	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234000110	Chorismate mutase type II; Region: CM_2; smart00830
458234000111	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
458234000112	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
458234000113	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
458234000114	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
458234000115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
458234000116	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
458234000117	active site
458234000118	dimer interface [polypeptide binding]; other site
458234000119	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
458234000120	phosphate binding site [ion binding]; other site
458234000121	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
458234000122	putative active site [active]
458234000123	dimerization interface [polypeptide binding]; other site
458234000124	putative tRNAtyr binding site [nucleotide binding]; other site
458234000125	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
458234000126	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
458234000127	substrate binding [chemical binding]; other site
458234000128	active site
458234000129	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000130	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000131	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000132	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000133	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
458234000134	putative FMN binding site [chemical binding]; other site
458234000135	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
458234000136	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
458234000137	aromatic amino acid transport protein; Region: araaP; TIGR00837
458234000138	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
458234000139	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
458234000140	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
458234000141	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
458234000142	catalytic residue [active]
458234000143	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
458234000144	Transcriptional regulator [Transcription]; Region: LysR; COG0583
458234000145	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
458234000146	putative effector binding pocket; other site
458234000147	dimerization interface [polypeptide binding]; other site
458234000148	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234000149	putative substrate translocation pore; other site
458234000150	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
458234000151	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
458234000152	dimer interface [polypeptide binding]; other site
458234000153	active site
458234000154	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
458234000155	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
458234000156	GTP-binding protein LepA; Provisional; Region: PRK05433
458234000157	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
458234000158	G1 box; other site
458234000159	putative GEF interaction site [polypeptide binding]; other site
458234000160	GTP/Mg2+ binding site [chemical binding]; other site
458234000161	Switch I region; other site
458234000162	G2 box; other site
458234000163	G3 box; other site
458234000164	Switch II region; other site
458234000165	G4 box; other site
458234000166	G5 box; other site
458234000167	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
458234000168	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
458234000169	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
458234000170	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
458234000171	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
458234000172	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
458234000173	active site
458234000174	catalytic residues [active]
458234000175	metal binding site [ion binding]; metal-binding site
458234000176	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
458234000177	homopentamer interface [polypeptide binding]; other site
458234000178	active site
458234000179	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
458234000180	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
458234000181	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
458234000182	dimerization interface [polypeptide binding]; other site
458234000183	active site
458234000184	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
458234000185	Lumazine binding domain; Region: Lum_binding; pfam00677
458234000186	Lumazine binding domain; Region: Lum_binding; pfam00677
458234000187	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
458234000188	catalytic motif [active]
458234000189	Zn binding site [ion binding]; other site
458234000190	RibD C-terminal domain; Region: RibD_C; cl17279
458234000191	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000192	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000193	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000194	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234000196	putative substrate translocation pore; other site
458234000197	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
458234000198	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854
458234000199	hypothetical protein; Provisional; Region: PRK05421
458234000200	putative catalytic site [active]
458234000201	putative metal binding site [ion binding]; other site
458234000202	putative phosphate binding site [ion binding]; other site
458234000203	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
458234000204	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
458234000205	putative acyl-acceptor binding pocket; other site
458234000206	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
458234000207	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
458234000208	putative acyl-acceptor binding pocket; other site
458234000209	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
458234000210	4Fe-4S binding domain; Region: Fer4; cl02805
458234000211	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
458234000212	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
458234000213	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
458234000214	ATP-grasp domain; Region: ATP-grasp; pfam02222
458234000215	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
458234000216	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
458234000217	active site
458234000218	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
458234000219	Clp amino terminal domain; Region: Clp_N; pfam02861
458234000220	Clp amino terminal domain; Region: Clp_N; pfam02861
458234000221	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
458234000222	Walker A motif; other site
458234000223	ATP binding site [chemical binding]; other site
458234000224	Walker B motif; other site
458234000225	arginine finger; other site
458234000226	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
458234000227	Walker A motif; other site
458234000228	ATP binding site [chemical binding]; other site
458234000229	Walker B motif; other site
458234000230	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
458234000231	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
458234000232	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
458234000233	substrate binding site [chemical binding]; other site
458234000234	active site
458234000235	catalytic residues [active]
458234000236	heterodimer interface [polypeptide binding]; other site
458234000237	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
458234000238	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
458234000239	pyridoxal 5'-phosphate binding site [chemical binding]; other site
458234000240	catalytic residue [active]
458234000241	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
458234000242	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
458234000243	active site
458234000244	Zn binding site [ion binding]; other site
458234000245	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
458234000246	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
458234000247	Cl- selectivity filter; other site
458234000248	Cl- binding residues [ion binding]; other site
458234000249	pore gating glutamate residue; other site
458234000250	dimer interface [polypeptide binding]; other site
458234000251	H+/Cl- coupling transport residue; other site
458234000252	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
458234000253	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
458234000254	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000255	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000256	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000257	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000258	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234000259	putative substrate translocation pore; other site
458234000260	type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358
458234000261	Protein of unknown function (DUF877); Region: DUF877; pfam05943
458234000262	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
458234000263	Intracellular growth locus C protein; Region: IglC; pfam11550
458234000264	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
458234000265	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
458234000266	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
458234000267	RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117
458234000268	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000269	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000270	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000271	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000272	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
458234000273	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
458234000274	homodimer interface [polypeptide binding]; other site
458234000275	substrate-cofactor binding pocket; other site
458234000276	catalytic residue [active]
458234000277	pyruvate phosphate dikinase; Provisional; Region: PRK09279
458234000278	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
458234000279	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
458234000280	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
458234000281	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
458234000282	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
458234000283	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
458234000284	G1 box; other site
458234000285	GTP/Mg2+ binding site [chemical binding]; other site
458234000286	Switch I region; other site
458234000287	G2 box; other site
458234000288	G3 box; other site
458234000289	Switch II region; other site
458234000290	G4 box; other site
458234000291	G5 box; other site
458234000292	Nucleoside recognition; Region: Gate; pfam07670
458234000293	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
458234000294	Nucleoside recognition; Region: Gate; pfam07670
458234000295	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000296	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000297	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000298	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000299	Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672
458234000300	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
458234000301	RNB domain; Region: RNB; pfam00773
458234000302	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
458234000303	putative hydrolase; Provisional; Region: PRK11460
458234000304	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
458234000305	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
458234000306	domain interfaces; other site
458234000307	active site
458234000308	camphor resistance protein CrcB; Provisional; Region: PRK14226
458234000309	Zinc-finger domain; Region: zf-CHCC; cl01821
458234000310	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
458234000311	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
458234000312	dimer interface [polypeptide binding]; other site
458234000313	conserved gate region; other site
458234000314	putative PBP binding loops; other site
458234000315	ABC-ATPase subunit interface; other site
458234000316	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
458234000317	dimer interface [polypeptide binding]; other site
458234000318	conserved gate region; other site
458234000319	putative PBP binding loops; other site
458234000320	ABC-ATPase subunit interface; other site
458234000321	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
458234000322	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
458234000323	Walker A/P-loop; other site
458234000324	ATP binding site [chemical binding]; other site
458234000325	Q-loop/lid; other site
458234000326	ABC transporter signature motif; other site
458234000327	Walker B; other site
458234000328	D-loop; other site
458234000329	H-loop/switch region; other site
458234000330	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
458234000331	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
458234000332	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
458234000333	TrkA-N domain; Region: TrkA_N; pfam02254
458234000334	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
458234000335	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
458234000336	trimer interface [polypeptide binding]; other site
458234000337	putative metal binding site [ion binding]; other site
458234000338	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
458234000339	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
458234000340	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
458234000341	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000342	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000343	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000344	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000345	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
458234000346	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
458234000347	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
458234000348	Phosphoesterase family; Region: Phosphoesterase; pfam04185
458234000349	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
458234000350	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
458234000351	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
458234000352	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000353	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000354	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000355	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000356	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
458234000357	Ligand Binding Site [chemical binding]; other site
458234000358	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
458234000359	Ligand Binding Site [chemical binding]; other site
458234000360	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
458234000361	PLD-like domain; Region: PLDc_2; pfam13091
458234000362	putative homodimer interface [polypeptide binding]; other site
458234000363	putative active site [active]
458234000364	catalytic site [active]
458234000365	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
458234000366	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
458234000367	ATP binding site [chemical binding]; other site
458234000368	putative Mg++ binding site [ion binding]; other site
458234000369	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
458234000370	nucleotide binding region [chemical binding]; other site
458234000371	ATP-binding site [chemical binding]; other site
458234000372	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
458234000373	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
458234000374	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
458234000375	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
458234000376	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
458234000377	Mitochondrial PGP phosphatase; Region: PGP_phosphatase; pfam09419
458234000378	Predicted methyltransferases [General function prediction only]; Region: COG0313
458234000379	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
458234000380	putative SAM binding site [chemical binding]; other site
458234000381	putative homodimer interface [polypeptide binding]; other site
458234000382	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
458234000383	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
458234000384	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
458234000385	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
458234000386	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
458234000387	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
458234000388	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
458234000389	shikimate binding site; other site
458234000390	NAD(P) binding site [chemical binding]; other site
458234000391	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
458234000392	membrane protein insertase; Provisional; Region: PRK01318
458234000393	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
458234000394	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
458234000395	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
458234000396	putative acyl-acceptor binding pocket; other site
458234000397	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
458234000398	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
458234000399	putative acyl-acceptor binding pocket; other site
458234000400	elongation factor P; Validated; Region: PRK00529
458234000401	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
458234000402	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
458234000403	RNA binding site [nucleotide binding]; other site
458234000404	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
458234000405	RNA binding site [nucleotide binding]; other site
458234000406	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
458234000407	catalytic site [active]
458234000408	putative active site [active]
458234000409	putative substrate binding site [chemical binding]; other site
458234000410	dimer interface [polypeptide binding]; other site
458234000411	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000412	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000413	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000414	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000415	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234000416	putative substrate translocation pore; other site
458234000417	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
458234000418	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
458234000419	substrate binding pocket [chemical binding]; other site
458234000420	membrane-bound complex binding site; other site
458234000421	hinge residues; other site
458234000422	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
458234000423	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
458234000424	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
458234000425	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
458234000426	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
458234000427	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234000428	Major Facilitator Superfamily; Region: MFS_1; pfam07690
458234000429	putative substrate translocation pore; other site
458234000430	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
458234000431	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
458234000432	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
458234000433	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
458234000434	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
458234000435	D-pathway; other site
458234000436	Putative ubiquinol binding site [chemical binding]; other site
458234000437	Low-spin heme (heme b) binding site [chemical binding]; other site
458234000438	Putative water exit pathway; other site
458234000439	Binuclear center (heme o3/CuB) [ion binding]; other site
458234000440	K-pathway; other site
458234000441	Putative proton exit pathway; other site
458234000442	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
458234000443	Subunit I/III interface [polypeptide binding]; other site
458234000444	Subunit III/IV interface [polypeptide binding]; other site
458234000445	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
458234000446	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
458234000447	UbiA prenyltransferase family; Region: UbiA; pfam01040
458234000448	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244
458234000449	pyridoxamine kinase; Validated; Region: PRK05756
458234000450	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
458234000451	dimer interface [polypeptide binding]; other site
458234000452	pyridoxal binding site [chemical binding]; other site
458234000453	ATP binding site [chemical binding]; other site
458234000454	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
458234000455	MoxR-like ATPases [General function prediction only]; Region: COG0714
458234000456	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
458234000457	Walker A motif; other site
458234000458	ATP binding site [chemical binding]; other site
458234000459	Walker B motif; other site
458234000460	arginine finger; other site
458234000461	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
458234000462	Protein of unknown function DUF58; Region: DUF58; pfam01882
458234000463	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
458234000464	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
458234000465	metal ion-dependent adhesion site (MIDAS); other site
458234000466	hypothetical protein; Provisional; Region: PRK13685
458234000467	von Willebrand factor type A domain; Region: VWA_2; pfam13519
458234000468	metal ion-dependent adhesion site (MIDAS); other site
458234000469	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
458234000470	Tetratricopeptide repeat; Region: TPR_16; pfam13432
458234000471	TPR motif; other site
458234000472	binding surface
458234000473	Oxygen tolerance; Region: BatD; pfam13584
458234000474	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
458234000475	putative substrate binding pocket [chemical binding]; other site
458234000476	AC domain interface; other site
458234000477	catalytic triad [active]
458234000478	AB domain interface; other site
458234000479	interchain disulfide; other site
458234000480	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
458234000481	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
458234000482	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
458234000483	active site
458234000484	HIGH motif; other site
458234000485	nucleotide binding site [chemical binding]; other site
458234000486	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
458234000487	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
458234000488	active site
458234000489	KMSKS motif; other site
458234000490	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
458234000491	tRNA binding surface [nucleotide binding]; other site
458234000492	anticodon binding site; other site
458234000493	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
458234000494	1-deoxy-D-xylulose-5-phosphate synthase; Region: PLN02225
458234000495	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
458234000496	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
458234000497	phosphate binding site [ion binding]; other site
458234000498	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
458234000499	dimer interface [polypeptide binding]; other site
458234000500	FMN binding site [chemical binding]; other site
458234000501	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
458234000502	nudix motif; other site
458234000503	fumarate hydratase; Reviewed; Region: fumC; PRK00485
458234000504	Class II fumarases; Region: Fumarase_classII; cd01362
458234000505	active site
458234000506	tetramer interface [polypeptide binding]; other site
458234000507	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
458234000508	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
458234000509	HIGH motif; other site
458234000510	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
458234000511	active site
458234000512	KMSKS motif; other site
458234000513	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
458234000514	Amidinotransferase; Region: Amidinotransf; pfam02274
458234000515	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
458234000516	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
458234000517	folate binding site [chemical binding]; other site
458234000518	NADP+ binding site [chemical binding]; other site
458234000519	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
458234000520	rRNA interaction site [nucleotide binding]; other site
458234000521	S8 interaction site; other site
458234000522	putative laminin-1 binding site; other site
458234000523	elongation factor Ts; Provisional; Region: tsf; PRK09377
458234000524	UBA/TS-N domain; Region: UBA; pfam00627
458234000525	Elongation factor TS; Region: EF_TS; pfam00889
458234000526	Elongation factor TS; Region: EF_TS; pfam00889
458234000527	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
458234000528	putative nucleotide binding site [chemical binding]; other site
458234000529	uridine monophosphate binding site [chemical binding]; other site
458234000530	homohexameric interface [polypeptide binding]; other site
458234000531	ribosome recycling factor; Reviewed; Region: frr; PRK00083
458234000532	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
458234000533	hinge region; other site
458234000534	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836
458234000535	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
458234000536	catalytic residue [active]
458234000537	putative FPP diphosphate  binding site; other site
458234000538	putative FPP binding hydrophobic cleft; other site
458234000539	dimer interface [polypeptide binding]; other site
458234000540	putative IPP diphosphate binding site; other site
458234000541	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
458234000542	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
458234000543	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
458234000544	trimer interface [polypeptide binding]; other site
458234000545	active site
458234000546	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
458234000547	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
458234000548	S17 interaction site [polypeptide binding]; other site
458234000549	S8 interaction site; other site
458234000550	16S rRNA interaction site [nucleotide binding]; other site
458234000551	streptomycin interaction site [chemical binding]; other site
458234000552	23S rRNA interaction site [nucleotide binding]; other site
458234000553	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
458234000554	30S ribosomal protein S7; Validated; Region: PRK05302
458234000555	elongation factor G; Reviewed; Region: PRK00007
458234000556	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
458234000557	G1 box; other site
458234000558	putative GEF interaction site [polypeptide binding]; other site
458234000559	GTP/Mg2+ binding site [chemical binding]; other site
458234000560	Switch I region; other site
458234000561	G2 box; other site
458234000562	G3 box; other site
458234000563	Switch II region; other site
458234000564	G4 box; other site
458234000565	G5 box; other site
458234000566	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
458234000567	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
458234000568	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
458234000569	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
458234000570	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
458234000571	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
458234000572	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
458234000573	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
458234000574	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
458234000575	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
458234000576	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
458234000577	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
458234000578	putative translocon binding site; other site
458234000579	protein-rRNA interface [nucleotide binding]; other site
458234000580	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
458234000581	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
458234000582	G-X-X-G motif; other site
458234000583	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
458234000584	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
458234000585	23S rRNA interface [nucleotide binding]; other site
458234000586	5S rRNA interface [nucleotide binding]; other site
458234000587	putative antibiotic binding site [chemical binding]; other site
458234000588	L25 interface [polypeptide binding]; other site
458234000589	L27 interface [polypeptide binding]; other site
458234000590	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
458234000591	23S rRNA interface [nucleotide binding]; other site
458234000592	putative translocon interaction site; other site
458234000593	signal recognition particle (SRP54) interaction site; other site
458234000594	L23 interface [polypeptide binding]; other site
458234000595	trigger factor interaction site; other site
458234000596	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
458234000597	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
458234000598	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
458234000599	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
458234000600	RNA binding site [nucleotide binding]; other site
458234000601	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
458234000602	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
458234000603	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
458234000604	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
458234000605	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
458234000606	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
458234000607	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
458234000608	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
458234000609	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
458234000610	23S rRNA interface [nucleotide binding]; other site
458234000611	L21e interface [polypeptide binding]; other site
458234000612	5S rRNA interface [nucleotide binding]; other site
458234000613	L27 interface [polypeptide binding]; other site
458234000614	L5 interface [polypeptide binding]; other site
458234000615	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
458234000616	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
458234000617	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
458234000618	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
458234000619	23S rRNA binding site [nucleotide binding]; other site
458234000620	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
458234000621	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
458234000622	SecY translocase; Region: SecY; pfam00344
458234000623	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
458234000624	30S ribosomal protein S13; Region: bact_S13; TIGR03631
458234000625	30S ribosomal protein S11; Validated; Region: PRK05309
458234000626	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
458234000627	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
458234000628	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
458234000629	RNA binding surface [nucleotide binding]; other site
458234000630	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
458234000631	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
458234000632	alphaNTD homodimer interface [polypeptide binding]; other site
458234000633	alphaNTD - beta interaction site [polypeptide binding]; other site
458234000634	alphaNTD - beta' interaction site [polypeptide binding]; other site
458234000635	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
458234000636	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
458234000637	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000638	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000639	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000640	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000641	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
458234000642	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000643	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000644	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000645	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000646	heat shock protein 90; Provisional; Region: PRK05218
458234000647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
458234000648	ATP binding site [chemical binding]; other site
458234000649	Mg2+ binding site [ion binding]; other site
458234000650	G-X-G motif; other site
458234000651	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000652	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000653	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000654	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000655	glutamate dehydrogenase; Provisional; Region: PRK09414
458234000656	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
458234000657	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
458234000658	NAD(P) binding site [chemical binding]; other site
458234000659	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234000660	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234000661	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234000662	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
458234000663	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
458234000664	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
458234000665	active site
458234000666	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
458234000667	substrate binding site [chemical binding]; other site
458234000668	catalytic residues [active]
458234000669	dimer interface [polypeptide binding]; other site
458234000670	Amino acid permease; Region: AA_permease_2; pfam13520
458234000671	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
458234000672	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
458234000673	DNA binding site [nucleotide binding]
458234000674	active site
458234000675	Uncharacterized conserved protein [Function unknown]; Region: COG0398
458234000676	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
458234000677	mercuric reductase; Validated; Region: PRK06370
458234000678	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
458234000679	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
458234000680	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
458234000681	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
458234000682	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
458234000683	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
458234000684	HSP70 interaction site [polypeptide binding]; other site
458234000685	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
458234000686	substrate binding site [polypeptide binding]; other site
458234000687	dimer interface [polypeptide binding]; other site
458234000688	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
458234000689	EamA-like transporter family; Region: EamA; pfam00892
458234000690	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
458234000691	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
458234000692	HD domain; Region: HD_4; pfam13328
458234000693	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
458234000694	synthetase active site [active]
458234000695	NTP binding site [chemical binding]; other site
458234000696	metal binding site [ion binding]; metal-binding site
458234000697	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
458234000698	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
458234000699	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
458234000700	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
458234000701	S-adenosylmethionine binding site [chemical binding]; other site
458234000702	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
458234000703	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
458234000704	active site
458234000705	DNA binding site [nucleotide binding]
458234000706	Int/Topo IB signature motif; other site
458234000707	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
458234000708	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
458234000709	preprotein translocase subunit SecB; Validated; Region: PRK05751
458234000710	SecA binding site; other site
458234000711	Preprotein binding site; other site
458234000712	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
458234000713	MutS domain I; Region: MutS_I; pfam01624
458234000714	MutS domain III; Region: MutS_III; pfam05192
458234000715	MutS domain V; Region: MutS_V; pfam00488
458234000716	Walker A/P-loop; other site
458234000717	ATP binding site [chemical binding]; other site
458234000718	Q-loop/lid; other site
458234000719	ABC transporter signature motif; other site
458234000720	Walker B; other site
458234000721	D-loop; other site
458234000722	H-loop/switch region; other site
458234000723	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
458234000724	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
458234000725	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
458234000726	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
458234000727	putative active site [active]
458234000728	Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890
458234000729	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234000730	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234000731	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
458234000732	Zeta toxin; Region: Zeta_toxin; pfam06414
458234000733	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
458234000734	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
458234000735	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
458234000736	active site
458234000737	HIGH motif; other site
458234000738	dimer interface [polypeptide binding]; other site
458234000739	KMSKS motif; other site
458234000740	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
458234000741	dephospho-CoA kinase; Region: TIGR00152
458234000742	CoA-binding site [chemical binding]; other site
458234000743	ATP-binding [chemical binding]; other site
458234000744	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
458234000745	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
458234000746	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
458234000747	dimer interface [polypeptide binding]; other site
458234000748	TPP-binding site [chemical binding]; other site
458234000749	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
458234000750	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
458234000751	E3 interaction surface; other site
458234000752	lipoyl attachment site [posttranslational modification]; other site
458234000753	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
458234000754	E3 interaction surface; other site
458234000755	lipoyl attachment site [posttranslational modification]; other site
458234000756	e3 binding domain; Region: E3_binding; pfam02817
458234000757	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
458234000758	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
458234000759	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
458234000760	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
458234000761	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
458234000762	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000763	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000764	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000765	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000766	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
458234000767	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
458234000768	nudix motif; other site
458234000769	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
458234000770	ArsC family; Region: ArsC; pfam03960
458234000771	catalytic residue [active]
458234000772	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
458234000773	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
458234000774	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
458234000775	pyridoxal 5'-phosphate binding site [chemical binding]; other site
458234000776	homodimer interface [polypeptide binding]; other site
458234000777	catalytic residue [active]
458234000778	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
458234000779	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
458234000780	ligand binding site [chemical binding]; other site
458234000781	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
458234000782	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
458234000783	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
458234000784	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
458234000785	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
458234000786	homotrimer interaction site [polypeptide binding]; other site
458234000787	active site
458234000788	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
458234000789	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
458234000790	TolQ protein; Region: tolQ; TIGR02796
458234000791	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
458234000792	TolR protein; Region: tolR; TIGR02801
458234000793	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
458234000794	TolB amino-terminal domain; Region: TolB_N; pfam04052
458234000795	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
458234000796	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
458234000797	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
458234000798	ligand binding site [chemical binding]; other site
458234000799	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
458234000800	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
458234000801	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
458234000802	FeS/SAM binding site; other site
458234000803	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
458234000804	Coenzyme A binding pocket [chemical binding]; other site
458234000805	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000806	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000807	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000808	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000809	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
458234000810	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
458234000811	bile acid transporter; Region: bass; TIGR00841
458234000812	Sodium Bile acid symporter family; Region: SBF; cl17470
458234000813	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
458234000814	Protein of unknown function (DUF423); Region: DUF423; pfam04241
458234000815	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234000816	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234000817	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234000818	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234000819	Protein of unknown function, DUF393; Region: DUF393; pfam04134
458234000820	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847
458234000821	UbiA prenyltransferase family; Region: UbiA; pfam01040
458234000822	Chorismate lyase; Region: Chor_lyase; cl01230
458234000823	ribonuclease PH; Reviewed; Region: rph; PRK00173
458234000824	Ribonuclease PH; Region: RNase_PH_bact; cd11362
458234000825	hexamer interface [polypeptide binding]; other site
458234000826	active site
458234000827	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
458234000828	heat shock protein HtpX; Provisional; Region: PRK02870
458234000829	LemA family; Region: LemA; cl00742
458234000830	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
458234000831	dimerization interface [polypeptide binding]; other site
458234000832	putative DNA binding site [nucleotide binding]; other site
458234000833	putative Zn2+ binding site [ion binding]; other site
458234000834	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
458234000835	putative active site [active]
458234000836	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
458234000837	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
458234000838	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
458234000839	Colicin V production protein; Region: Colicin_V; pfam02674
458234000840	DNA repair protein RadA; Provisional; Region: PRK11823
458234000841	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
458234000842	Walker A motif/ATP binding site; other site
458234000843	ATP binding site [chemical binding]; other site
458234000844	Walker B motif; other site
458234000845	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
458234000846	PilZ domain; Region: PilZ; pfam07238
458234000847	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
458234000848	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
458234000849	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
458234000850	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
458234000851	Tetramer interface [polypeptide binding]; other site
458234000852	active site
458234000853	FMN-binding site [chemical binding]; other site
458234000854	PQ loop repeat; Region: PQ-loop; pfam04193
458234000855	methionine sulfoxide reductase B; Provisional; Region: PRK00222
458234000856	SelR domain; Region: SelR; pfam01641
458234000857	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
458234000858	E-class dimer interface [polypeptide binding]; other site
458234000859	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
458234000860	P-class dimer interface [polypeptide binding]; other site
458234000861	active site
458234000862	Cu2+ binding site [ion binding]; other site
458234000863	Zn2+ binding site [ion binding]; other site
458234000864	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
458234000865	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
458234000866	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
458234000867	Cupin domain; Region: Cupin_2; cl17218
458234000868	aspartate aminotransferase; Provisional; Region: PRK07568
458234000869	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
458234000870	pyridoxal 5'-phosphate binding site [chemical binding]; other site
458234000871	homodimer interface [polypeptide binding]; other site
458234000872	catalytic residue [active]
458234000873	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
458234000874	Cation efflux family; Region: Cation_efflux; pfam01545
458234000875	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
458234000876	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
458234000877	Walker A/P-loop; other site
458234000878	ATP binding site [chemical binding]; other site
458234000879	Q-loop/lid; other site
458234000880	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
458234000881	ABC transporter signature motif; other site
458234000882	Walker B; other site
458234000883	D-loop; other site
458234000884	H-loop/switch region; other site
458234000885	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
458234000886	Pilin (bacterial filament); Region: Pilin; pfam00114
458234000887	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
458234000888	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
458234000889	active site
458234000890	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180
458234000891	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
458234000892	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
458234000893	homodimer interface [polypeptide binding]; other site
458234000894	NADP binding site [chemical binding]; other site
458234000895	substrate binding site [chemical binding]; other site
458234000896	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
458234000897	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
458234000898	dimerization interface [polypeptide binding]; other site
458234000899	putative ATP binding site [chemical binding]; other site
458234000900	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
458234000901	active site
458234000902	ATP binding site [chemical binding]; other site
458234000903	substrate binding site [chemical binding]; other site
458234000904	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
458234000905	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
458234000906	ATP-grasp domain; Region: ATP-grasp_4; cl17255
458234000907	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
458234000908	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
458234000909	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
458234000910	active site
458234000911	substrate binding site [chemical binding]; other site
458234000912	cosubstrate binding site; other site
458234000913	catalytic site [active]
458234000914	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
458234000915	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
458234000916	ATP-grasp domain; Region: ATP-grasp; pfam02222
458234000917	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234000918	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234000919	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234000920	intracellular septation protein A; Reviewed; Region: PRK00259
458234000921	Glucokinase; Region: Glucokinase; pfam02685
458234000922	glucokinase, proteobacterial type; Region: glk; TIGR00749
458234000923	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
458234000924	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
458234000925	S-adenosylmethionine binding site [chemical binding]; other site
458234000926	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
458234000927	ABC1 family; Region: ABC1; cl17513
458234000928	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
458234000929	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
458234000930	nucleotide binding site/active site [active]
458234000931	HIT family signature motif; other site
458234000932	catalytic residue [active]
458234000933	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
458234000934	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
458234000935	active site
458234000936	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
458234000937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
458234000938	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
458234000939	FAD binding domain; Region: FAD_binding_4; pfam01565
458234000940	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
458234000941	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
458234000942	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
458234000943	putative active site [active]
458234000944	GTP-binding protein Der; Reviewed; Region: PRK00093
458234000945	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
458234000946	G1 box; other site
458234000947	GTP/Mg2+ binding site [chemical binding]; other site
458234000948	Switch I region; other site
458234000949	G2 box; other site
458234000950	Switch II region; other site
458234000951	G3 box; other site
458234000952	G4 box; other site
458234000953	G5 box; other site
458234000954	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
458234000955	G1 box; other site
458234000956	GTP/Mg2+ binding site [chemical binding]; other site
458234000957	Switch I region; other site
458234000958	G2 box; other site
458234000959	G3 box; other site
458234000960	Switch II region; other site
458234000961	G4 box; other site
458234000962	G5 box; other site
458234000963	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234000964	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234000965	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234000966	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
458234000967	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
458234000968	active site
458234000969	Zn binding site [ion binding]; other site
458234000970	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
458234000971	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
458234000972	DNA topoisomerase I; Validated; Region: PRK06599
458234000973	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
458234000974	active site
458234000975	interdomain interaction site; other site
458234000976	putative metal-binding site [ion binding]; other site
458234000977	nucleotide binding site [chemical binding]; other site
458234000978	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
458234000979	domain I; other site
458234000980	DNA binding groove [nucleotide binding]
458234000981	phosphate binding site [ion binding]; other site
458234000982	domain II; other site
458234000983	domain III; other site
458234000984	nucleotide binding site [chemical binding]; other site
458234000985	catalytic site [active]
458234000986	domain IV; other site
458234000987	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
458234000988	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
458234000989	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
458234000990	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
458234000991	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
458234000992	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
458234000993	P-loop; other site
458234000994	Magnesium ion binding site [ion binding]; other site
458234000995	ParB-like nuclease domain; Region: ParB; smart00470
458234000996	KorB domain; Region: KorB; pfam08535
458234000997	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
458234000998	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
458234000999	catalytic triad [active]
458234001000	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
458234001001	active site
458234001002	catalytic triad [active]
458234001003	oxyanion hole [active]
458234001004	FtsJ-like methyltransferase; Region: FtsJ; cl17430
458234001005	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
458234001006	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
458234001007	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
458234001008	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
458234001009	active site
458234001010	HIGH motif; other site
458234001011	nucleotide binding site [chemical binding]; other site
458234001012	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
458234001013	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
458234001014	active site
458234001015	KMSKS motif; other site
458234001016	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
458234001017	tRNA binding surface [nucleotide binding]; other site
458234001018	anticodon binding site; other site
458234001019	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
458234001020	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
458234001021	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
458234001022	active site
458234001023	Riboflavin kinase; Region: Flavokinase; pfam01687
458234001024	malate dehydrogenase; Provisional; Region: PRK13529
458234001025	Malic enzyme, N-terminal domain; Region: malic; pfam00390
458234001026	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
458234001027	NAD(P) binding pocket [chemical binding]; other site
458234001028	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
458234001029	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
458234001030	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234001031	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234001032	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234001033	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234001034	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
458234001035	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
458234001036	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234001037	D-galactonate transporter; Region: 2A0114; TIGR00893
458234001038	putative substrate translocation pore; other site
458234001039	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
458234001040	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
458234001041	active site
458234001042	HIGH motif; other site
458234001043	KMSKS motif; other site
458234001044	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
458234001045	tRNA binding surface [nucleotide binding]; other site
458234001046	anticodon binding site; other site
458234001047	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
458234001048	dimer interface [polypeptide binding]; other site
458234001049	putative tRNA-binding site [nucleotide binding]; other site
458234001050	Predicted flavoprotein [General function prediction only]; Region: COG0431
458234001051	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
458234001052	Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931
458234001053	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
458234001054	Peptidase family M50; Region: Peptidase_M50; pfam02163
458234001055	active site
458234001056	putative substrate binding region [chemical binding]; other site
458234001057	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
458234001058	DNA binding residues [nucleotide binding]
458234001059	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
458234001060	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
458234001061	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168
458234001062	active site
458234001063	(T/H)XGH motif; other site
458234001064	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
458234001065	nudix motif; other site
458234001066	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
458234001067	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
458234001068	Substrate binding site; other site
458234001069	Mg++ binding site; other site
458234001070	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
458234001071	active site
458234001072	substrate binding site [chemical binding]; other site
458234001073	CoA binding site [chemical binding]; other site
458234001074	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
458234001075	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
458234001076	glutaminase active site [active]
458234001077	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
458234001078	dimer interface [polypeptide binding]; other site
458234001079	active site
458234001080	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
458234001081	dimer interface [polypeptide binding]; other site
458234001082	active site
458234001083	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
458234001084	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
458234001085	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
458234001086	DNA-binding site [nucleotide binding]; DNA binding site
458234001087	RNA-binding motif; other site
458234001088	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
458234001089	metal binding site [ion binding]; metal-binding site
458234001090	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
458234001091	active site
458234001092	PLD-like domain; Region: PLDc_2; pfam13091
458234001093	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
458234001094	putative homodimer interface [polypeptide binding]; other site
458234001095	putative active site [active]
458234001096	catalytic site [active]
458234001097	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
458234001098	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
458234001099	CAP-like domain; other site
458234001100	active site
458234001101	primary dimer interface [polypeptide binding]; other site
458234001102	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
458234001103	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
458234001104	BNR repeat-like domain; Region: BNR_2; pfam13088
458234001105	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
458234001106	Asp-box motif; other site
458234001107	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
458234001108	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
458234001109	N-acetyl-D-glucosamine binding site [chemical binding]; other site
458234001110	catalytic residue [active]
458234001111	Predicted membrane protein [Function unknown]; Region: COG4325
458234001112	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
458234001113	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
458234001114	putative active site [active]
458234001115	putative PHP Thumb interface [polypeptide binding]; other site
458234001116	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
458234001117	generic binding surface II; other site
458234001118	generic binding surface I; other site
458234001119	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
458234001120	active site
458234001121	catalytic residues [active]
458234001122	metal binding site [ion binding]; metal-binding site
458234001123	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
458234001124	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
458234001125	FtsX-like permease family; Region: FtsX; pfam02687
458234001126	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
458234001127	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
458234001128	Walker A/P-loop; other site
458234001129	ATP binding site [chemical binding]; other site
458234001130	Q-loop/lid; other site
458234001131	ABC transporter signature motif; other site
458234001132	Walker B; other site
458234001133	D-loop; other site
458234001134	H-loop/switch region; other site
458234001135	lysine decarboxylase LdcC; Provisional; Region: PRK15399
458234001136	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
458234001137	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
458234001138	homodimer interface [polypeptide binding]; other site
458234001139	pyridoxal 5'-phosphate binding site [chemical binding]; other site
458234001140	catalytic residue [active]
458234001141	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
458234001142	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
458234001143	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
458234001144	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
458234001145	lipoyl attachment site [posttranslational modification]; other site
458234001146	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
458234001147	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
458234001148	tetramer interface [polypeptide binding]; other site
458234001149	pyridoxal 5'-phosphate binding site [chemical binding]; other site
458234001150	catalytic residue [active]
458234001151	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
458234001152	tetramer interface [polypeptide binding]; other site
458234001153	pyridoxal 5'-phosphate binding site [chemical binding]; other site
458234001154	catalytic residue [active]
458234001155	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
458234001156	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
458234001157	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
458234001158	shikimate binding site; other site
458234001159	NAD(P) binding site [chemical binding]; other site
458234001160	pullulanase, type I; Region: pulA_typeI; TIGR02104
458234001161	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
458234001162	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
458234001163	Ca binding site [ion binding]; other site
458234001164	active site
458234001165	catalytic site [active]
458234001166	glycogen branching enzyme; Provisional; Region: PRK12313
458234001167	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
458234001168	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
458234001169	active site
458234001170	catalytic site [active]
458234001171	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
458234001172	phosphoglucomutase; Region: PLN02307
458234001173	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
458234001174	substrate binding site [chemical binding]; other site
458234001175	dimer interface [polypeptide binding]; other site
458234001176	active site
458234001177	metal binding site [ion binding]; metal-binding site
458234001178	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
458234001179	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
458234001180	ligand binding site; other site
458234001181	oligomer interface; other site
458234001182	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
458234001183	dimer interface [polypeptide binding]; other site
458234001184	N-terminal domain interface [polypeptide binding]; other site
458234001185	sulfate 1 binding site; other site
458234001186	glycogen synthase; Provisional; Region: glgA; PRK00654
458234001187	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
458234001188	ADP-binding pocket [chemical binding]; other site
458234001189	homodimer interface [polypeptide binding]; other site
458234001190	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
458234001191	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
458234001192	4-alpha-glucanotransferase; Provisional; Region: PRK14508
458234001193	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
458234001194	dimer interface [polypeptide binding]; other site
458234001195	motif 1; other site
458234001196	active site
458234001197	motif 2; other site
458234001198	motif 3; other site
458234001199	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
458234001200	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
458234001201	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
458234001202	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
458234001203	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
458234001204	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
458234001205	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
458234001206	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
458234001207	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
458234001208	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
458234001209	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
458234001210	nucleotide binding site [chemical binding]; other site
458234001211	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
458234001212	dimer interface [polypeptide binding]; other site
458234001213	putative threonine allosteric regulatory site; other site
458234001214	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
458234001215	homoserine kinase; Provisional; Region: PRK01212
458234001216	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
458234001217	threonine synthase; Validated; Region: PRK09225
458234001218	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
458234001219	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
458234001220	catalytic residue [active]
458234001221	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
458234001222	spermidine synthase; Provisional; Region: PRK00811
458234001223	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
458234001224	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234001225	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234001226	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234001227	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234001228	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
458234001229	putative active site [active]
458234001230	putative metal binding site [ion binding]; other site
458234001231	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
458234001232	active site
458234001233	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
458234001234	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
458234001235	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
458234001236	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
458234001237	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
458234001238	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
458234001239	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234001240	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234001241	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234001242	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234001243	BolA-like protein; Region: BolA; cl00386
458234001244	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
458234001245	anti sigma factor interaction site; other site
458234001246	regulatory phosphorylation site [posttranslational modification]; other site
458234001247	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
458234001248	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
458234001249	mce related protein; Region: MCE; pfam02470
458234001250	Permease; Region: Permease; pfam02405
458234001251	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
458234001252	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
458234001253	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
458234001254	Walker A/P-loop; other site
458234001255	ATP binding site [chemical binding]; other site
458234001256	Q-loop/lid; other site
458234001257	ABC transporter signature motif; other site
458234001258	Walker B; other site
458234001259	D-loop; other site
458234001260	H-loop/switch region; other site
458234001261	cell division topological specificity factor MinE; Provisional; Region: PRK13990
458234001262	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
458234001263	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
458234001264	Switch I; other site
458234001265	Switch II; other site
458234001266	septum formation inhibitor; Reviewed; Region: minC; PRK04804
458234001267	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
458234001268	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
458234001269	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
458234001270	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
458234001271	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627
458234001272	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
458234001273	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
458234001274	ssDNA binding site; other site
458234001275	generic binding surface II; other site
458234001276	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
458234001277	ATP binding site [chemical binding]; other site
458234001278	putative Mg++ binding site [ion binding]; other site
458234001279	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
458234001280	nucleotide binding region [chemical binding]; other site
458234001281	ATP-binding site [chemical binding]; other site
458234001282	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
458234001283	Fumarase C-terminus; Region: Fumerase_C; pfam05683
458234001284	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234001285	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234001286	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
458234001287	GIY-YIG motif/motif A; other site
458234001288	putative active site [active]
458234001289	putative metal binding site [ion binding]; other site
458234001290	Restriction endonuclease [Defense mechanisms]; Region: COG3587
458234001291	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
458234001292	ATP binding site [chemical binding]; other site
458234001293	putative Mg++ binding site [ion binding]; other site
458234001294	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
458234001295	ligand binding site [chemical binding]; other site
458234001296	active site
458234001297	UGI interface [polypeptide binding]; other site
458234001298	catalytic site [active]
458234001299	DNA gyrase subunit A; Validated; Region: PRK05560
458234001300	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
458234001301	CAP-like domain; other site
458234001302	active site
458234001303	primary dimer interface [polypeptide binding]; other site
458234001304	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
458234001305	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
458234001306	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
458234001307	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
458234001308	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
458234001309	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
458234001310	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
458234001311	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
458234001312	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
458234001313	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
458234001314	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
458234001315	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
458234001316	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
458234001317	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
458234001318	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
458234001319	Surface antigen; Region: Bac_surface_Ag; pfam01103
458234001320	periplasmic chaperone; Provisional; Region: PRK10780
458234001321	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
458234001322	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
458234001323	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
458234001324	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
458234001325	trimer interface [polypeptide binding]; other site
458234001326	active site
458234001327	UDP-GlcNAc binding site [chemical binding]; other site
458234001328	lipid binding site [chemical binding]; lipid-binding site
458234001329	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
458234001330	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
458234001331	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
458234001332	active site
458234001333	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
458234001334	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
458234001335	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
458234001336	active site
458234001337	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
458234001338	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
458234001339	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
458234001340	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
458234001341	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
458234001342	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
458234001343	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
458234001344	substrate binding pocket [chemical binding]; other site
458234001345	chain length determination region; other site
458234001346	substrate-Mg2+ binding site; other site
458234001347	catalytic residues [active]
458234001348	aspartate-rich region 1; other site
458234001349	active site lid residues [active]
458234001350	aspartate-rich region 2; other site
458234001351	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
458234001352	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
458234001353	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
458234001354	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
458234001355	active site
458234001356	dimerization interface [polypeptide binding]; other site
458234001357	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
458234001358	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
458234001359	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
458234001360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
458234001361	active site
458234001362	phosphorylation site [posttranslational modification]
458234001363	intermolecular recognition site; other site
458234001364	dimerization interface [polypeptide binding]; other site
458234001365	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
458234001366	DNA binding site [nucleotide binding]
458234001367	signal peptidase I; Provisional; Region: PRK10861
458234001368	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
458234001369	Catalytic site [active]
458234001370	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
458234001371	ribonuclease III; Reviewed; Region: rnc; PRK00102
458234001372	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
458234001373	dimerization interface [polypeptide binding]; other site
458234001374	active site
458234001375	metal binding site [ion binding]; metal-binding site
458234001376	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
458234001377	dsRNA binding site [nucleotide binding]; other site
458234001378	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
458234001379	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
458234001380	RNA binding site [nucleotide binding]; other site
458234001381	active site
458234001382	ribonuclease R; Region: RNase_R; TIGR02063
458234001383	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
458234001384	RNB domain; Region: RNB; pfam00773
458234001385	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
458234001386	RNA binding site [nucleotide binding]; other site
458234001387	Fatty acid desaturase; Region: FA_desaturase; pfam00487
458234001388	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
458234001389	Di-iron ligands [ion binding]; other site
458234001390	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
458234001391	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
458234001392	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
458234001393	NAD(P) binding site [chemical binding]; other site
458234001394	active site
458234001395	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
458234001396	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
458234001397	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
458234001398	S-adenosylmethionine binding site [chemical binding]; other site
458234001399	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
458234001400	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234001401	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234001402	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234001403	uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722
458234001404	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
458234001405	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234001406	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234001407	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234001408	ornithine cyclodeaminase; Validated; Region: PRK07589
458234001409	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
458234001410	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
458234001411	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
458234001412	active site
458234001413	Protein of unknown function (DUF465); Region: DUF465; pfam04325
458234001414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234001415	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
458234001416	putative substrate translocation pore; other site
458234001417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
458234001418	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
458234001419	CoenzymeA binding site [chemical binding]; other site
458234001420	subunit interaction site [polypeptide binding]; other site
458234001421	PHB binding site; other site
458234001422	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
458234001423	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
458234001424	dimer interface [polypeptide binding]; other site
458234001425	active site
458234001426	Acyl CoA binding protein; Region: ACBP; pfam00887
458234001427	acyl-CoA binding pocket [chemical binding]; other site
458234001428	CoA binding site [chemical binding]; other site
458234001429	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
458234001430	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
458234001431	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
458234001432	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
458234001433	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
458234001434	substrate binding site [chemical binding]; other site
458234001435	oxyanion hole (OAH) forming residues; other site
458234001436	trimer interface [polypeptide binding]; other site
458234001437	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
458234001438	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
458234001439	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
458234001440	active site
458234001441	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
458234001442	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
458234001443	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
458234001444	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
458234001445	acyl-activating enzyme (AAE) consensus motif; other site
458234001446	AMP binding site [chemical binding]; other site
458234001447	active site
458234001448	CoA binding site [chemical binding]; other site
458234001449	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
458234001450	ArsC family; Region: ArsC; pfam03960
458234001451	catalytic residues [active]
458234001452	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
458234001453	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
458234001454	DEAD-like helicases superfamily; Region: DEXDc; smart00487
458234001455	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
458234001456	ATP binding site [chemical binding]; other site
458234001457	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
458234001458	putative Mg++ binding site [ion binding]; other site
458234001459	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
458234001460	nucleotide binding region [chemical binding]; other site
458234001461	ATP-binding site [chemical binding]; other site
458234001462	Helicase associated domain (HA2); Region: HA2; pfam04408
458234001463	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
458234001464	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
458234001465	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
458234001466	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234001467	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234001468	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234001469	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
458234001470	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
458234001471	NAD(P) binding site [chemical binding]; other site
458234001472	homodimer interface [polypeptide binding]; other site
458234001473	substrate binding site [chemical binding]; other site
458234001474	active site
458234001475	Bacterial sugar transferase; Region: Bac_transf; pfam02397
458234001476	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
458234001477	NADH(P)-binding; Region: NAD_binding_10; pfam13460
458234001478	NAD(P) binding site [chemical binding]; other site
458234001479	active site
458234001480	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
458234001481	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
458234001482	putative ADP-binding pocket [chemical binding]; other site
458234001483	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
458234001484	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
458234001485	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
458234001486	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
458234001487	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
458234001488	NAD binding site [chemical binding]; other site
458234001489	substrate binding site [chemical binding]; other site
458234001490	homodimer interface [polypeptide binding]; other site
458234001491	active site
458234001492	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
458234001493	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
458234001494	putative ADP-binding pocket [chemical binding]; other site
458234001495	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
458234001496	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
458234001497	active site
458234001498	dimer interface [polypeptide binding]; other site
458234001499	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
458234001500	Ligand Binding Site [chemical binding]; other site
458234001501	Molecular Tunnel; other site
458234001502	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
458234001503	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
458234001504	inhibitor-cofactor binding pocket; inhibition site
458234001505	pyridoxal 5'-phosphate binding site [chemical binding]; other site
458234001506	catalytic residue [active]
458234001507	hypothetical protein; Provisional; Region: PRK07579
458234001508	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
458234001509	active site
458234001510	cosubstrate binding site; other site
458234001511	substrate binding site [chemical binding]; other site
458234001512	catalytic site [active]
458234001513	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
458234001514	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
458234001515	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
458234001516	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
458234001517	active site
458234001518	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
458234001519	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
458234001520	substrate binding site; other site
458234001521	tetramer interface; other site
458234001522	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
458234001523	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
458234001524	NAD binding site [chemical binding]; other site
458234001525	substrate binding site [chemical binding]; other site
458234001526	homodimer interface [polypeptide binding]; other site
458234001527	active site
458234001528	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234001529	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234001530	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234001531	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234001532	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
458234001533	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
458234001534	Substrate binding site; other site
458234001535	Cupin domain; Region: Cupin_2; cl17218
458234001536	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
458234001537	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
458234001538	active site
458234001539	substrate binding site [chemical binding]; other site
458234001540	metal binding site [ion binding]; metal-binding site
458234001541	transcription termination factor Rho; Provisional; Region: rho; PRK09376
458234001542	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
458234001543	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
458234001544	RNA binding site [nucleotide binding]; other site
458234001545	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
458234001546	multimer interface [polypeptide binding]; other site
458234001547	Walker A motif; other site
458234001548	ATP binding site [chemical binding]; other site
458234001549	Walker B motif; other site
458234001550	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
458234001551	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
458234001552	catalytic residues [active]
458234001553	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234001554	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234001555	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234001556	recombination factor protein RarA; Provisional; Region: PRK14700
458234001557	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
458234001558	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
458234001559	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
458234001560	dimer interface [polypeptide binding]; other site
458234001561	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
458234001562	Ferritin-like domain; Region: Ferritin; pfam00210
458234001563	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
458234001564	dinuclear metal binding motif [ion binding]; other site
458234001565	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
458234001566	active site
458234001567	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234001568	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234001569	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234001570	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
458234001571	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
458234001572	Walker A/P-loop; other site
458234001573	ATP binding site [chemical binding]; other site
458234001574	Q-loop/lid; other site
458234001575	ABC transporter signature motif; other site
458234001576	Walker B; other site
458234001577	D-loop; other site
458234001578	H-loop/switch region; other site
458234001579	inner membrane transport permease; Provisional; Region: PRK15066
458234001580	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
458234001581	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
458234001582	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
458234001583	Ligand binding site; other site
458234001584	Putative Catalytic site; other site
458234001585	DXD motif; other site
458234001586	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
458234001587	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
458234001588	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
458234001589	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
458234001590	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234001591	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234001592	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234001593	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234001594	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
458234001595	putative DNA binding site [nucleotide binding]; other site
458234001596	putative Zn2+ binding site [ion binding]; other site
458234001597	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
458234001598	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
458234001599	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
458234001600	hypothetical protein; Provisional; Region: PRK05170
458234001601	transcription antitermination factor NusB; Region: nusB; TIGR01951
458234001602	putative RNA binding site [nucleotide binding]; other site
458234001603	C-N hydrolase family amidase; Provisional; Region: PRK10438
458234001604	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
458234001605	putative active site [active]
458234001606	catalytic triad [active]
458234001607	dimer interface [polypeptide binding]; other site
458234001608	multimer interface [polypeptide binding]; other site
458234001609	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
458234001610	prolyl-tRNA synthetase; Provisional; Region: PRK09194
458234001611	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
458234001612	dimer interface [polypeptide binding]; other site
458234001613	motif 1; other site
458234001614	active site
458234001615	motif 2; other site
458234001616	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
458234001617	putative deacylase active site [active]
458234001618	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
458234001619	active site
458234001620	motif 3; other site
458234001621	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
458234001622	anticodon binding site; other site
458234001623	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
458234001624	Fe-S metabolism associated domain; Region: SufE; cl00951
458234001625	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
458234001626	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
458234001627	active site
458234001628	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
458234001629	Sporulation related domain; Region: SPOR; pfam05036
458234001630	FeoA domain; Region: FeoA; cl00838
458234001631	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
458234001632	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
458234001633	non-specific DNA binding site [nucleotide binding]; other site
458234001634	salt bridge; other site
458234001635	sequence-specific DNA binding site [nucleotide binding]; other site
458234001636	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
458234001637	Catalytic site [active]
458234001638	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
458234001639	EamA-like transporter family; Region: EamA; pfam00892
458234001640	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
458234001641	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
458234001642	active site
458234001643	FMN binding site [chemical binding]; other site
458234001644	substrate binding site [chemical binding]; other site
458234001645	3Fe-4S cluster binding site [ion binding]; other site
458234001646	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
458234001647	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
458234001648	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
458234001649	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
458234001650	Divergent AAA domain; Region: AAA_4; pfam04326
458234001651	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
458234001652	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
458234001653	putative DNA binding site [nucleotide binding]; other site
458234001654	putative Zn2+ binding site [ion binding]; other site
458234001655	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
458234001656	Family description; Region: UvrD_C_2; pfam13538
458234001657	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
458234001658	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
458234001659	AAA domain; Region: AAA_30; pfam13604
458234001660	Family description; Region: UvrD_C_2; pfam13538
458234001661	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
458234001662	nucleotide binding site [chemical binding]; other site
458234001663	Type III pantothenate kinase; Region: Pan_kinase; cl17198
458234001664	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
458234001665	tetramerization interface [polypeptide binding]; other site
458234001666	active site
458234001667	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
458234001668	pantoate--beta-alanine ligase; Region: panC; TIGR00018
458234001669	active site
458234001670	nucleotide binding site [chemical binding]; other site
458234001671	HIGH motif; other site
458234001672	KMSKS motif; other site
458234001673	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
458234001674	active site
458234001675	oligomerization interface [polypeptide binding]; other site
458234001676	metal binding site [ion binding]; metal-binding site
458234001677	Uncharacterized conserved protein [Function unknown]; Region: COG5495
458234001678	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
458234001679	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
458234001680	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
458234001681	nucleotide binding pocket [chemical binding]; other site
458234001682	K-X-D-G motif; other site
458234001683	catalytic site [active]
458234001684	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
458234001685	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
458234001686	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
458234001687	Dimer interface [polypeptide binding]; other site
458234001688	BRCT sequence motif; other site
458234001689	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
458234001690	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234001691	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234001692	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234001693	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234001694	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
458234001695	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
458234001696	dimer interface [polypeptide binding]; other site
458234001697	conserved gate region; other site
458234001698	putative PBP binding loops; other site
458234001699	ABC-ATPase subunit interface; other site
458234001700	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
458234001701	dimer interface [polypeptide binding]; other site
458234001702	conserved gate region; other site
458234001703	putative PBP binding loops; other site
458234001704	ABC-ATPase subunit interface; other site
458234001705	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
458234001706	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
458234001707	Walker A/P-loop; other site
458234001708	ATP binding site [chemical binding]; other site
458234001709	Q-loop/lid; other site
458234001710	ABC transporter signature motif; other site
458234001711	Walker B; other site
458234001712	D-loop; other site
458234001713	H-loop/switch region; other site
458234001714	TOBE domain; Region: TOBE_2; pfam08402
458234001715	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234001716	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234001717	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234001718	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234001719	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
458234001720	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
458234001721	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
458234001722	homodimer interface [polypeptide binding]; other site
458234001723	NAD binding pocket [chemical binding]; other site
458234001724	ATP binding pocket [chemical binding]; other site
458234001725	Mg binding site [ion binding]; other site
458234001726	active-site loop [active]
458234001727	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
458234001728	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
458234001729	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
458234001730	HlyD family secretion protein; Region: HlyD_3; pfam13437
458234001731	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
458234001732	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234001733	putative substrate translocation pore; other site
458234001734	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
458234001735	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
458234001736	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
458234001737	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
458234001738	acyl-activating enzyme (AAE) consensus motif; other site
458234001739	putative AMP binding site [chemical binding]; other site
458234001740	putative active site [active]
458234001741	putative CoA binding site [chemical binding]; other site
458234001742	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
458234001743	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234001744	putative substrate translocation pore; other site
458234001745	POT family; Region: PTR2; cl17359
458234001746	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
458234001747	RNA methyltransferase, RsmE family; Region: TIGR00046
458234001748	Protein of unknown function (DUF445); Region: DUF445; pfam04286
458234001749	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
458234001750	mce related protein; Region: MCE; pfam02470
458234001751	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
458234001752	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
458234001753	Walker A/P-loop; other site
458234001754	ATP binding site [chemical binding]; other site
458234001755	Q-loop/lid; other site
458234001756	ABC transporter signature motif; other site
458234001757	Walker B; other site
458234001758	D-loop; other site
458234001759	H-loop/switch region; other site
458234001760	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
458234001761	Permease; Region: Permease; pfam02405
458234001762	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
458234001763	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
458234001764	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
458234001765	RNA binding surface [nucleotide binding]; other site
458234001766	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
458234001767	active site
458234001768	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
458234001769	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
458234001770	TPR motif; other site
458234001771	binding surface
458234001772	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
458234001773	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
458234001774	dimer interface [polypeptide binding]; other site
458234001775	active site
458234001776	glycine-pyridoxal phosphate binding site [chemical binding]; other site
458234001777	folate binding site [chemical binding]; other site
458234001778	hypothetical protein; Provisional; Region: PRK05255
458234001779	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
458234001780	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
458234001781	Ligand binding site; other site
458234001782	metal-binding site
458234001783	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
458234001784	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
458234001785	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
458234001786	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
458234001787	active site
458234001788	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
458234001789	Ligand Binding Site [chemical binding]; other site
458234001790	TilS substrate C-terminal domain; Region: TilS_C; smart00977
458234001791	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
458234001792	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
458234001793	ligand binding site [chemical binding]; other site
458234001794	NAD binding site [chemical binding]; other site
458234001795	tetramer interface [polypeptide binding]; other site
458234001796	catalytic site [active]
458234001797	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
458234001798	L-serine binding site [chemical binding]; other site
458234001799	ACT domain interface; other site
458234001800	thymidylate synthase; Reviewed; Region: thyA; PRK01827
458234001801	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
458234001802	dimerization interface [polypeptide binding]; other site
458234001803	active site
458234001804	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
458234001805	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
458234001806	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
458234001807	homodimer interface [polypeptide binding]; other site
458234001808	oligonucleotide binding site [chemical binding]; other site
458234001809	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
458234001810	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
458234001811	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
458234001812	catalytic residue [active]
458234001813	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
458234001814	Recombination protein O N terminal; Region: RecO_N; pfam11967
458234001815	Recombination protein O C terminal; Region: RecO_C; pfam02565
458234001816	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
458234001817	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
458234001818	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
458234001819	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
458234001820	BolA-like protein; Region: BolA; cl00386
458234001821	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
458234001822	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
458234001823	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
458234001824	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
458234001825	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
458234001826	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
458234001827	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
458234001828	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
458234001829	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
458234001830	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
458234001831	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
458234001832	active site
458234001833	motif I; other site
458234001834	motif II; other site
458234001835	Soluble P-type ATPase [General function prediction only]; Region: COG4087
458234001836	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
458234001837	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
458234001838	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
458234001839	dimer interface [polypeptide binding]; other site
458234001840	active site
458234001841	metal binding site [ion binding]; metal-binding site
458234001842	glutathione binding site [chemical binding]; other site
458234001843	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234001844	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234001845	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234001846	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234001847	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
458234001848	tetramer (dimer of dimers) interface [polypeptide binding]; other site
458234001849	active site
458234001850	dimer interface [polypeptide binding]; other site
458234001851	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
458234001852	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
458234001853	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
458234001854	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
458234001855	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
458234001856	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
458234001857	NAD(P) binding site [chemical binding]; other site
458234001858	active site
458234001859	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
458234001860	active site
458234001861	catalytic site [active]
458234001862	substrate binding site [chemical binding]; other site
458234001863	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
458234001864	excinuclease ABC subunit B; Provisional; Region: PRK05298
458234001865	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
458234001866	ATP binding site [chemical binding]; other site
458234001867	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
458234001868	nucleotide binding region [chemical binding]; other site
458234001869	ATP-binding site [chemical binding]; other site
458234001870	Ultra-violet resistance protein B; Region: UvrB; pfam12344
458234001871	UvrB/uvrC motif; Region: UVR; pfam02151
458234001872	Nuclease-related domain; Region: NERD; pfam08378
458234001873	glutamate racemase; Provisional; Region: PRK00865
458234001874	metabolite-proton symporter; Region: 2A0106; TIGR00883
458234001875	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234001876	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234001877	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234001878	Uncharacterized conserved protein [Function unknown]; Region: COG2308
458234001879	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
458234001880	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
458234001881	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
458234001882	putative dimer interface [polypeptide binding]; other site
458234001883	putative active site [active]
458234001884	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
458234001885	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
458234001886	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
458234001887	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
458234001888	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
458234001889	generic binding surface II; other site
458234001890	generic binding surface I; other site
458234001891	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
458234001892	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
458234001893	Ligand Binding Site [chemical binding]; other site
458234001894	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
458234001895	SmpB-tmRNA interface; other site
458234001896	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
458234001897	putative coenzyme Q binding site [chemical binding]; other site
458234001898	hypothetical protein; Validated; Region: PRK01777
458234001899	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
458234001900	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
458234001901	VacJ like lipoprotein; Region: VacJ; cl01073
458234001902	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
458234001903	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
458234001904	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
458234001905	S-adenosylmethionine binding site [chemical binding]; other site
458234001906	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
458234001907	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
458234001908	G1 box; other site
458234001909	putative GEF interaction site [polypeptide binding]; other site
458234001910	GTP/Mg2+ binding site [chemical binding]; other site
458234001911	Switch I region; other site
458234001912	G2 box; other site
458234001913	G3 box; other site
458234001914	Switch II region; other site
458234001915	G4 box; other site
458234001916	G5 box; other site
458234001917	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
458234001918	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
458234001919	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
458234001920	DNA-binding site [nucleotide binding]; DNA binding site
458234001921	RNA-binding motif; other site
458234001922	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234001923	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234001924	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234001925	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234001926	Sel1-like repeats; Region: SEL1; smart00671
458234001927	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
458234001928	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
458234001929	GTP/Mg2+ binding site [chemical binding]; other site
458234001930	G4 box; other site
458234001931	G5 box; other site
458234001932	G1 box; other site
458234001933	Switch I region; other site
458234001934	G2 box; other site
458234001935	G3 box; other site
458234001936	Switch II region; other site
458234001937	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
458234001938	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
458234001939	active site
458234001940	dimer interface [polypeptide binding]; other site
458234001941	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
458234001942	Glycoprotease family; Region: Peptidase_M22; pfam00814
458234001943	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
458234001944	putative active site [active]
458234001945	putative dimer interface [polypeptide binding]; other site
458234001946	aspartate aminotransferase; Provisional; Region: PRK05764
458234001947	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
458234001948	pyridoxal 5'-phosphate binding site [chemical binding]; other site
458234001949	homodimer interface [polypeptide binding]; other site
458234001950	catalytic residue [active]
458234001951	GTPase Era; Reviewed; Region: era; PRK00089
458234001952	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
458234001953	G1 box; other site
458234001954	GTP/Mg2+ binding site [chemical binding]; other site
458234001955	Switch I region; other site
458234001956	G2 box; other site
458234001957	Switch II region; other site
458234001958	G3 box; other site
458234001959	G4 box; other site
458234001960	G5 box; other site
458234001961	adenylate kinase; Reviewed; Region: adk; PRK00279
458234001962	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
458234001963	AMP-binding site [chemical binding]; other site
458234001964	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
458234001965	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
458234001966	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
458234001967	Pilus assembly protein, PilO; Region: PilO; cl01234
458234001968	Pilus assembly protein, PilP; Region: PilP; pfam04351
458234001969	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
458234001970	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
458234001971	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
458234001972	shikimate kinase; Reviewed; Region: aroK; PRK00131
458234001973	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
458234001974	ADP binding site [chemical binding]; other site
458234001975	magnesium binding site [ion binding]; other site
458234001976	putative shikimate binding site; other site
458234001977	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
458234001978	active site
458234001979	dimer interface [polypeptide binding]; other site
458234001980	metal binding site [ion binding]; metal-binding site
458234001981	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
458234001982	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
458234001983	Proline dehydrogenase; Region: Pro_dh; pfam01619
458234001984	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
458234001985	Glutamate binding site [chemical binding]; other site
458234001986	NAD binding site [chemical binding]; other site
458234001987	catalytic residues [active]
458234001988	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
458234001989	NAD(P) binding site [chemical binding]; other site
458234001990	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
458234001991	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
458234001992	benzoate transport; Region: 2A0115; TIGR00895
458234001993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234001994	putative substrate translocation pore; other site
458234001995	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
458234001996	Flavoprotein; Region: Flavoprotein; pfam02441
458234001997	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
458234001998	Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572
458234001999	PRC-barrel domain; Region: PRC; pfam05239
458234002000	PRC-barrel domain; Region: PRC; pfam05239
458234002001	DNA photolyase; Region: DNA_photolyase; pfam00875
458234002002	ferrochelatase; Reviewed; Region: hemH; PRK00035
458234002003	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
458234002004	C-terminal domain interface [polypeptide binding]; other site
458234002005	active site
458234002006	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
458234002007	active site
458234002008	N-terminal domain interface [polypeptide binding]; other site
458234002009	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
458234002010	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
458234002011	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
458234002012	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
458234002013	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
458234002014	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
458234002015	Walker A motif; other site
458234002016	ATP binding site [chemical binding]; other site
458234002017	Walker B motif; other site
458234002018	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
458234002019	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
458234002020	active site
458234002021	catalytic site [active]
458234002022	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
458234002023	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
458234002024	putative MPT binding site; other site
458234002025	cyanophycin synthetase; Provisional; Region: PRK14016
458234002026	ATP-grasp domain; Region: ATP-grasp_4; cl17255
458234002027	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
458234002028	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
458234002029	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
458234002030	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
458234002031	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
458234002032	homotrimer interaction site [polypeptide binding]; other site
458234002033	zinc binding site [ion binding]; other site
458234002034	CDP-binding sites; other site
458234002035	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
458234002036	active site residue [active]
458234002037	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
458234002038	active site residue [active]
458234002039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
458234002040	dimer interface [polypeptide binding]; other site
458234002041	conserved gate region; other site
458234002042	putative PBP binding loops; other site
458234002043	ABC-ATPase subunit interface; other site
458234002044	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
458234002045	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
458234002046	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
458234002047	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
458234002048	Walker A/P-loop; other site
458234002049	ATP binding site [chemical binding]; other site
458234002050	Q-loop/lid; other site
458234002051	ABC transporter signature motif; other site
458234002052	Walker B; other site
458234002053	D-loop; other site
458234002054	H-loop/switch region; other site
458234002055	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
458234002056	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
458234002057	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676
458234002058	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
458234002059	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
458234002060	Isochorismatase family; Region: Isochorismatase; pfam00857
458234002061	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
458234002062	catalytic triad [active]
458234002063	conserved cis-peptide bond; other site
458234002064	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
458234002065	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
458234002066	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
458234002067	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
458234002068	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
458234002069	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
458234002070	Protein export membrane protein; Region: SecD_SecF; pfam02355
458234002071	Src Homology 3 domain superfamily; Region: SH3; cl17036
458234002072	peptide ligand binding site [polypeptide binding]; other site
458234002073	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
458234002074	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
458234002075	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
458234002076	DNA binding residues [nucleotide binding]
458234002077	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
458234002078	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
458234002079	hinge; other site
458234002080	active site
458234002081	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
458234002082	RNA/DNA hybrid binding site [nucleotide binding]; other site
458234002083	active site
458234002084	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
458234002085	active site
458234002086	homodimer interface [polypeptide binding]; other site
458234002087	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
458234002088	active site clefts [active]
458234002089	zinc binding site [ion binding]; other site
458234002090	dimer interface [polypeptide binding]; other site
458234002091	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
458234002092	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
458234002093	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
458234002094	catalytic residue [active]
458234002095	Rubredoxin [Energy production and conversion]; Region: COG1773
458234002096	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
458234002097	iron binding site [ion binding]; other site
458234002098	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234002099	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234002100	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234002101	Uncharacterized conserved protein [Function unknown]; Region: COG0397
458234002102	hypothetical protein; Validated; Region: PRK00029
458234002103	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
458234002104	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
458234002105	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
458234002106	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
458234002107	dimer interface [polypeptide binding]; other site
458234002108	active site
458234002109	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
458234002110	dimer interface [polypeptide binding]; other site
458234002111	active site
458234002112	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234002113	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
458234002114	putative substrate translocation pore; other site
458234002115	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234002116	Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662
458234002117	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
458234002118	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
458234002119	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
458234002120	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
458234002121	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
458234002122	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
458234002123	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
458234002124	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
458234002125	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
458234002126	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
458234002127	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
458234002128	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
458234002129	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
458234002130	active site
458234002131	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
458234002132	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
458234002133	active site
458234002134	substrate binding site [chemical binding]; other site
458234002135	Mg2+ binding site [ion binding]; other site
458234002136	beta-lactamase TEM; Provisional; Region: PRK15442
458234002137	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
458234002138	VirK protein; Region: VirK; pfam06903
458234002139	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
458234002140	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
458234002141	putative active site [active]
458234002142	catalytic triad [active]
458234002143	putative dimer interface [polypeptide binding]; other site
458234002144	FOG: CBS domain [General function prediction only]; Region: COG0517
458234002145	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
458234002146	Transporter associated domain; Region: CorC_HlyC; smart01091
458234002147	metal-binding heat shock protein; Provisional; Region: PRK00016
458234002148	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
458234002149	PhoH-like protein; Region: PhoH; pfam02562
458234002150	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
458234002151	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
458234002152	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
458234002153	FeS/SAM binding site; other site
458234002154	TRAM domain; Region: TRAM; pfam01938
458234002155	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
458234002156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
458234002157	thymidine kinase; Provisional; Region: PRK04296
458234002158	trigger factor; Provisional; Region: tig; PRK01490
458234002159	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
458234002160	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
458234002161	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
458234002162	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
458234002163	oligomer interface [polypeptide binding]; other site
458234002164	active site residues [active]
458234002165	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
458234002166	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
458234002167	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
458234002168	Walker A motif; other site
458234002169	ATP binding site [chemical binding]; other site
458234002170	Walker B motif; other site
458234002171	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
458234002172	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
458234002173	Found in ATP-dependent protease La (LON); Region: LON; smart00464
458234002174	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
458234002175	Walker A motif; other site
458234002176	ATP binding site [chemical binding]; other site
458234002177	Walker B motif; other site
458234002178	arginine finger; other site
458234002179	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
458234002180	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
458234002181	IHF dimer interface [polypeptide binding]; other site
458234002182	IHF - DNA interface [nucleotide binding]; other site
458234002183	SurA N-terminal domain; Region: SurA_N_3; cl07813
458234002184	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
458234002185	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
458234002186	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
458234002187	bacterial Hfq-like; Region: Hfq; cd01716
458234002188	hexamer interface [polypeptide binding]; other site
458234002189	Sm1 motif; other site
458234002190	RNA binding site [nucleotide binding]; other site
458234002191	Sm2 motif; other site
458234002192	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
458234002193	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
458234002194	HflX GTPase family; Region: HflX; cd01878
458234002195	G1 box; other site
458234002196	GTP/Mg2+ binding site [chemical binding]; other site
458234002197	Switch I region; other site
458234002198	G2 box; other site
458234002199	G3 box; other site
458234002200	Switch II region; other site
458234002201	G4 box; other site
458234002202	G5 box; other site
458234002203	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
458234002204	HflK protein; Region: hflK; TIGR01933
458234002205	FtsH protease regulator HflC; Provisional; Region: PRK11029
458234002206	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
458234002207	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
458234002208	Low molecular weight phosphatase family; Region: LMWPc; cd00115
458234002209	active site
458234002210	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
458234002211	G1 box; other site
458234002212	GTP/Mg2+ binding site [chemical binding]; other site
458234002213	Switch I region; other site
458234002214	G2 box; other site
458234002215	G3 box; other site
458234002216	Switch II region; other site
458234002217	G4 box; other site
458234002218	G5 box; other site
458234002219	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
458234002220	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
458234002221	putative valine binding site [chemical binding]; other site
458234002222	dimer interface [polypeptide binding]; other site
458234002223	ketol-acid reductoisomerase; Region: ilvC; TIGR00465
458234002224	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
458234002225	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
458234002226	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
458234002227	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
458234002228	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
458234002229	ATP binding site [chemical binding]; other site
458234002230	putative Mg++ binding site [ion binding]; other site
458234002231	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
458234002232	nucleotide binding region [chemical binding]; other site
458234002233	ATP-binding site [chemical binding]; other site
458234002234	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
458234002235	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
458234002236	YccA-like proteins; Region: YccA_like; cd10433
458234002237	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
458234002238	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
458234002239	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
458234002240	minor groove reading motif; other site
458234002241	helix-hairpin-helix signature motif; other site
458234002242	substrate binding pocket [chemical binding]; other site
458234002243	active site
458234002244	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
458234002245	ferredoxin; Provisional; Region: PRK08764
458234002246	Putative Fe-S cluster; Region: FeS; cl17515
458234002247	4Fe-4S binding domain; Region: Fer4; pfam00037
458234002248	glutaredoxin 2; Provisional; Region: PRK10387
458234002249	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
458234002250	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
458234002251	N-terminal domain interface [polypeptide binding]; other site
458234002252	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
458234002253	Ferritin-like domain; Region: Ferritin; pfam00210
458234002254	ferroxidase diiron center [ion binding]; other site
458234002255	lipoyl synthase; Provisional; Region: PRK05481
458234002256	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
458234002257	FeS/SAM binding site; other site
458234002258	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
458234002259	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
458234002260	conserved cys residue [active]
458234002261	hypothetical protein; Validated; Region: PRK00110
458234002262	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
458234002263	active site
458234002264	putative DNA-binding cleft [nucleotide binding]; other site
458234002265	dimer interface [polypeptide binding]; other site
458234002266	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234002267	putative substrate translocation pore; other site
458234002268	D-galactonate transporter; Region: 2A0114; TIGR00893
458234002269	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
458234002270	RuvA N terminal domain; Region: RuvA_N; pfam01330
458234002271	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
458234002272	RmuC family; Region: RmuC; pfam02646
458234002273	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337
458234002274	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
458234002275	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
458234002276	histidine decarboxylase; Provisional; Region: PRK02769
458234002277	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
458234002278	catalytic residue [active]
458234002279	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
458234002280	intersubunit interface [polypeptide binding]; other site
458234002281	active site
458234002282	Zn2+ binding site [ion binding]; other site
458234002283	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
458234002284	active site
458234002285	DNA binding site [nucleotide binding]
458234002286	Isochorismatase family; Region: Isochorismatase; pfam00857
458234002287	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
458234002288	catalytic triad [active]
458234002289	conserved cis-peptide bond; other site
458234002290	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
458234002291	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
458234002292	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
458234002293	Mechanosensitive ion channel; Region: MS_channel; pfam00924
458234002294	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
458234002295	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
458234002296	putative active site [active]
458234002297	Zn binding site [ion binding]; other site
458234002298	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
458234002299	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
458234002300	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
458234002301	active site
458234002302	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
458234002303	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
458234002304	5S rRNA interface [nucleotide binding]; other site
458234002305	CTC domain interface [polypeptide binding]; other site
458234002306	L16 interface [polypeptide binding]; other site
458234002307	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
458234002308	Domain of unknown function DUF21; Region: DUF21; pfam01595
458234002309	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
458234002310	Transporter associated domain; Region: CorC_HlyC; pfam03471
458234002311	GTP-binding protein YchF; Reviewed; Region: PRK09601
458234002312	YchF GTPase; Region: YchF; cd01900
458234002313	G1 box; other site
458234002314	GTP/Mg2+ binding site [chemical binding]; other site
458234002315	Switch I region; other site
458234002316	G2 box; other site
458234002317	Switch II region; other site
458234002318	G3 box; other site
458234002319	G4 box; other site
458234002320	G5 box; other site
458234002321	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
458234002322	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
458234002323	putative active site [active]
458234002324	catalytic residue [active]
458234002325	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
458234002326	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
458234002327	dimerization domain [polypeptide binding]; other site
458234002328	dimer interface [polypeptide binding]; other site
458234002329	catalytic residues [active]
458234002330	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
458234002331	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
458234002332	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
458234002333	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
458234002334	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
458234002335	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
458234002336	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
458234002337	POT family; Region: PTR2; cl17359
458234002338	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
458234002339	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
458234002340	Walker A motif; other site
458234002341	ATP binding site [chemical binding]; other site
458234002342	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
458234002343	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
458234002344	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
458234002345	active site
458234002346	HslU subunit interaction site [polypeptide binding]; other site
458234002347	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
458234002348	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
458234002349	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
458234002350	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
458234002351	active site
458234002352	HIGH motif; other site
458234002353	dimer interface [polypeptide binding]; other site
458234002354	KMSKS motif; other site
458234002355	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
458234002356	RNA binding surface [nucleotide binding]; other site
458234002357	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234002358	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234002359	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234002360	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234002361	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
458234002362	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
458234002363	phosphate binding site [ion binding]; other site
458234002364	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
458234002365	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
458234002366	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
458234002367	dimer interface [polypeptide binding]; other site
458234002368	active site
458234002369	metal binding site [ion binding]; metal-binding site
458234002370	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
458234002371	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
458234002372	S-adenosylmethionine binding site [chemical binding]; other site
458234002373	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
458234002374	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
458234002375	FMN binding site [chemical binding]; other site
458234002376	active site
458234002377	catalytic residues [active]
458234002378	substrate binding site [chemical binding]; other site
458234002379	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
458234002380	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
458234002381	Methyltransferase domain; Region: Methyltransf_26; pfam13659
458234002382	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
458234002383	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
458234002384	putative active site [active]
458234002385	AAA domain; Region: AAA_21; pfam13304
458234002386	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
458234002387	ABC transporter signature motif; other site
458234002388	Walker B; other site
458234002389	D-loop; other site
458234002390	H-loop/switch region; other site
458234002391	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
458234002392	active site
458234002393	DNA polymerase IV; Validated; Region: PRK02406
458234002394	DNA binding site [nucleotide binding]
458234002395	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
458234002396	DJ-1 family protein; Region: not_thiJ; TIGR01383
458234002397	conserved cys residue [active]
458234002398	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
458234002399	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
458234002400	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
458234002401	bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759
458234002402	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
458234002403	GSH binding site [chemical binding]; other site
458234002404	catalytic residues [active]
458234002405	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
458234002406	dimer interface [polypeptide binding]; other site
458234002407	putative radical transfer pathway; other site
458234002408	diiron center [ion binding]; other site
458234002409	tyrosyl radical; other site
458234002410	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
458234002411	GSH binding site [chemical binding]; other site
458234002412	catalytic residues [active]
458234002413	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
458234002414	Class I ribonucleotide reductase; Region: RNR_I; cd01679
458234002415	active site
458234002416	dimer interface [polypeptide binding]; other site
458234002417	catalytic residues [active]
458234002418	effector binding site; other site
458234002419	R2 peptide binding site; other site
458234002420	malate dehydrogenase; Reviewed; Region: PRK06223
458234002421	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
458234002422	NAD(P) binding site [chemical binding]; other site
458234002423	dimer interface [polypeptide binding]; other site
458234002424	tetramer (dimer of dimers) interface [polypeptide binding]; other site
458234002425	substrate binding site [chemical binding]; other site
458234002426	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
458234002427	diiron binding motif [ion binding]; other site
458234002428	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
458234002429	N-acetyl-D-glucosamine binding site [chemical binding]; other site
458234002430	catalytic residue [active]
458234002431	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234002432	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234002433	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234002434	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234002435	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
458234002436	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
458234002437	motif II; other site
458234002438	peroxidase; Provisional; Region: PRK15000
458234002439	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
458234002440	dimer interface [polypeptide binding]; other site
458234002441	decamer (pentamer of dimers) interface [polypeptide binding]; other site
458234002442	catalytic triad [active]
458234002443	peroxidatic and resolving cysteines [active]
458234002444	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
458234002445	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
458234002446	PhnA protein; Region: PhnA; pfam03831
458234002447	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
458234002448	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
458234002449	active site
458234002450	catalytic site [active]
458234002451	substrate binding site [chemical binding]; other site
458234002452	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
458234002453	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
458234002454	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
458234002455	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
458234002456	putative homodimer interface [polypeptide binding]; other site
458234002457	putative homotetramer interface [polypeptide binding]; other site
458234002458	putative allosteric switch controlling residues; other site
458234002459	putative metal binding site [ion binding]; other site
458234002460	putative homodimer-homodimer interface [polypeptide binding]; other site
458234002461	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
458234002462	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
458234002463	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
458234002464	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
458234002465	dimerization interface [polypeptide binding]; other site
458234002466	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
458234002467	catalytic triad [active]
458234002468	dimer interface [polypeptide binding]; other site
458234002469	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
458234002470	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
458234002471	putative NAD(P) binding site [chemical binding]; other site
458234002472	homodimer interface [polypeptide binding]; other site
458234002473	cytidylate kinase; Provisional; Region: cmk; PRK00023
458234002474	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
458234002475	CMP-binding site; other site
458234002476	The sites determining sugar specificity; other site
458234002477	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
458234002478	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
458234002479	catalytic residue [active]
458234002480	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234002481	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234002482	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234002483	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234002484	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
458234002485	catalytic core [active]
458234002486	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
458234002487	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
458234002488	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
458234002489	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
458234002490	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
458234002491	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
458234002492	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
458234002493	replicative DNA helicase; Region: DnaB; TIGR00665
458234002494	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
458234002495	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
458234002496	Walker A motif; other site
458234002497	ATP binding site [chemical binding]; other site
458234002498	Walker B motif; other site
458234002499	DNA binding loops [nucleotide binding]
458234002500	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
458234002501	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
458234002502	FeS/SAM binding site; other site
458234002503	Tetratricopeptide repeat; Region: TPR_12; pfam13424
458234002504	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
458234002505	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
458234002506	RNA binding surface [nucleotide binding]; other site
458234002507	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
458234002508	probable active site [active]
458234002509	preprotein translocase subunit SecA; Validated; Region: secA; CHL00122
458234002510	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
458234002511	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
458234002512	Coenzyme A binding pocket [chemical binding]; other site
458234002513	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
458234002514	PQ loop repeat; Region: PQ-loop; pfam04193
458234002515	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
458234002516	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
458234002517	substrate binding pocket [chemical binding]; other site
458234002518	chain length determination region; other site
458234002519	substrate-Mg2+ binding site; other site
458234002520	catalytic residues [active]
458234002521	aspartate-rich region 1; other site
458234002522	active site lid residues [active]
458234002523	aspartate-rich region 2; other site
458234002524	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
458234002525	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
458234002526	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
458234002527	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
458234002528	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
458234002529	Ligand Binding Site [chemical binding]; other site
458234002530	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
458234002531	active site
458234002532	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
458234002533	N-acetyl-D-glucosamine binding site [chemical binding]; other site
458234002534	catalytic residue [active]
458234002535	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
458234002536	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
458234002537	Yqey-like protein; Region: YqeY; pfam09424
458234002538	CHC2 zinc finger; Region: zf-CHC2; pfam01807
458234002539	DNA primase; Validated; Region: dnaG; PRK05667
458234002540	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
458234002541	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
458234002542	active site
458234002543	metal binding site [ion binding]; metal-binding site
458234002544	interdomain interaction site; other site
458234002545	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
458234002546	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
458234002547	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
458234002548	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
458234002549	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
458234002550	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
458234002551	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
458234002552	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
458234002553	DNA binding residues [nucleotide binding]
458234002554	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
458234002555	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
458234002556	lipoate-protein ligase B; Provisional; Region: PRK14342
458234002557	Protein of unknown function (DUF493); Region: DUF493; pfam04359
458234002558	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
458234002559	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
458234002560	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
458234002561	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
458234002562	dimer interface [polypeptide binding]; other site
458234002563	substrate binding site [chemical binding]; other site
458234002564	metal binding sites [ion binding]; metal-binding site
458234002565	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
458234002566	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
458234002567	active site
458234002568	motif I; other site
458234002569	motif II; other site
458234002570	OstA-like protein; Region: OstA; cl00844
458234002571	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
458234002572	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
458234002573	Walker A/P-loop; other site
458234002574	ATP binding site [chemical binding]; other site
458234002575	Q-loop/lid; other site
458234002576	ABC transporter signature motif; other site
458234002577	Walker B; other site
458234002578	D-loop; other site
458234002579	H-loop/switch region; other site
458234002580	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
458234002581	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
458234002582	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
458234002583	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
458234002584	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
458234002585	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
458234002586	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
458234002587	dimerization interface 3.5A [polypeptide binding]; other site
458234002588	active site
458234002589	GMP synthase; Reviewed; Region: guaA; PRK00074
458234002590	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
458234002591	AMP/PPi binding site [chemical binding]; other site
458234002592	candidate oxyanion hole; other site
458234002593	catalytic triad [active]
458234002594	potential glutamine specificity residues [chemical binding]; other site
458234002595	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
458234002596	ATP Binding subdomain [chemical binding]; other site
458234002597	Ligand Binding sites [chemical binding]; other site
458234002598	Dimerization subdomain; other site
458234002599	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
458234002600	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
458234002601	TPP-binding site; other site
458234002602	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
458234002603	PYR/PP interface [polypeptide binding]; other site
458234002604	dimer interface [polypeptide binding]; other site
458234002605	TPP binding site [chemical binding]; other site
458234002606	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
458234002607	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
458234002608	putative active site pocket [active]
458234002609	dimerization interface [polypeptide binding]; other site
458234002610	putative catalytic residue [active]
458234002611	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
458234002612	active site
458234002613	catalytic triad [active]
458234002614	oxyanion hole [active]
458234002615	switch loop; other site
458234002616	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
458234002617	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
458234002618	classical (c) SDRs; Region: SDR_c; cd05233
458234002619	NAD(P) binding site [chemical binding]; other site
458234002620	active site
458234002621	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
458234002622	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
458234002623	Walker A motif; other site
458234002624	ATP binding site [chemical binding]; other site
458234002625	Walker B motif; other site
458234002626	arginine finger; other site
458234002627	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
458234002628	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
458234002629	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
458234002630	non-specific DNA binding site [nucleotide binding]; other site
458234002631	salt bridge; other site
458234002632	sequence-specific DNA binding site [nucleotide binding]; other site
458234002633	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
458234002634	active site
458234002635	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
458234002636	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
458234002637	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
458234002638	TspO/MBR family; Region: TspO_MBR; pfam03073
458234002639	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
458234002640	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
458234002641	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
458234002642	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
458234002643	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
458234002644	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
458234002645	catalytic residues [active]
458234002646	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
458234002647	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
458234002648	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
458234002649	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
458234002650	motif 1; other site
458234002651	active site
458234002652	motif 2; other site
458234002653	motif 3; other site
458234002654	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
458234002655	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
458234002656	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
458234002657	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
458234002658	interface (dimer of trimers) [polypeptide binding]; other site
458234002659	Substrate-binding/catalytic site; other site
458234002660	Zn-binding sites [ion binding]; other site
458234002661	transaldolase-like protein; Provisional; Region: PTZ00411
458234002662	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
458234002663	active site
458234002664	dimer interface [polypeptide binding]; other site
458234002665	catalytic residue [active]
458234002666	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234002667	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234002668	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234002669	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
458234002670	Isochorismatase family; Region: Isochorismatase; pfam00857
458234002671	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
458234002672	catalytic triad [active]
458234002673	conserved cis-peptide bond; other site
458234002674	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
458234002675	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
458234002676	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
458234002677	Part of AAA domain; Region: AAA_19; pfam13245
458234002678	Family description; Region: UvrD_C_2; pfam13538
458234002679	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
458234002680	S1 domain; Region: S1_2; pfam13509
458234002681	S1 domain; Region: S1_2; pfam13509
458234002682	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
458234002683	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
458234002684	active site residue [active]
458234002685	recombination associated protein; Reviewed; Region: rdgC; PRK00321
458234002686	HipA N-terminal domain; Region: couple_hipA; TIGR03071
458234002687	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
458234002688	HipA-like N-terminal domain; Region: HipA_N; pfam07805
458234002689	HipA-like C-terminal domain; Region: HipA_C; pfam07804
458234002690	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
458234002691	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
458234002692	non-specific DNA binding site [nucleotide binding]; other site
458234002693	salt bridge; other site
458234002694	sequence-specific DNA binding site [nucleotide binding]; other site
458234002695	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234002696	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234002697	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234002698	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234002699	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
458234002700	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
458234002701	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
458234002702	active site
458234002703	dimerization interface [polypeptide binding]; other site
458234002704	Predicted membrane protein [Function unknown]; Region: COG2855
458234002705	putative transporter; Provisional; Region: PRK03699
458234002706	Uncharacterized conserved protein [Function unknown]; Region: COG4121
458234002707	YCII-related domain; Region: YCII; cl00999
458234002708	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
458234002709	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
458234002710	dimer interface [polypeptide binding]; other site
458234002711	active site
458234002712	acyl carrier protein; Provisional; Region: acpP; PRK00982
458234002713	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
458234002714	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
458234002715	NAD(P) binding site [chemical binding]; other site
458234002716	homotetramer interface [polypeptide binding]; other site
458234002717	homodimer interface [polypeptide binding]; other site
458234002718	active site
458234002719	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
458234002720	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
458234002721	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
458234002722	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
458234002723	dimer interface [polypeptide binding]; other site
458234002724	active site
458234002725	CoA binding pocket [chemical binding]; other site
458234002726	putative phosphate acyltransferase; Provisional; Region: PRK05331
458234002727	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
458234002728	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
458234002729	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
458234002730	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
458234002731	TPP-binding site [chemical binding]; other site
458234002732	dimer interface [polypeptide binding]; other site
458234002733	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
458234002734	PYR/PP interface [polypeptide binding]; other site
458234002735	dimer interface [polypeptide binding]; other site
458234002736	TPP binding site [chemical binding]; other site
458234002737	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
458234002738	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
458234002739	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
458234002740	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
458234002741	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
458234002742	Phosphoglycerate kinase; Region: PGK; pfam00162
458234002743	substrate binding site [chemical binding]; other site
458234002744	hinge regions; other site
458234002745	ADP binding site [chemical binding]; other site
458234002746	catalytic site [active]
458234002747	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
458234002748	pyruvate kinase; Provisional; Region: PRK05826
458234002749	domain interfaces; other site
458234002750	active site
458234002751	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
458234002752	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
458234002753	intersubunit interface [polypeptide binding]; other site
458234002754	active site
458234002755	zinc binding site [ion binding]; other site
458234002756	Na+ binding site [ion binding]; other site
458234002757	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234002758	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234002759	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234002760	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234002761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234002762	putative substrate translocation pore; other site
458234002763	type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358
458234002764	Protein of unknown function (DUF877); Region: DUF877; pfam05943
458234002765	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
458234002766	Intracellular growth locus C protein; Region: IglC; pfam11550
458234002767	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370
458234002768	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
458234002769	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
458234002770	RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117
458234002771	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
458234002772	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
458234002773	dimer interface [polypeptide binding]; other site
458234002774	pyridoxal 5'-phosphate binding site [chemical binding]; other site
458234002775	catalytic residue [active]
458234002776	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
458234002777	active site
458234002778	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
458234002779	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
458234002780	trmE is a tRNA modification GTPase; Region: trmE; cd04164
458234002781	G1 box; other site
458234002782	GTP/Mg2+ binding site [chemical binding]; other site
458234002783	Switch I region; other site
458234002784	G2 box; other site
458234002785	Switch II region; other site
458234002786	G3 box; other site
458234002787	G4 box; other site
458234002788	G5 box; other site
458234002789	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
458234002790	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
458234002791	30S subunit binding site; other site
458234002792	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
458234002793	active site
458234002794	phosphorylation site [posttranslational modification]
458234002795	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
458234002796	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
458234002797	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
458234002798	RNA/DNA hybrid binding site [nucleotide binding]; other site
458234002799	active site
458234002800	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
458234002801	Na binding site [ion binding]; other site
458234002802	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
458234002803	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
458234002804	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
458234002805	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
458234002806	23S rRNA interface [nucleotide binding]; other site
458234002807	L3 interface [polypeptide binding]; other site
458234002808	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
458234002809	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
458234002810	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
458234002811	MltA specific insert domain; Region: MltA; smart00925
458234002812	3D domain; Region: 3D; pfam06725
458234002813	GrpE; Region: GrpE; pfam01025
458234002814	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
458234002815	dimer interface [polypeptide binding]; other site
458234002816	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
458234002817	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
458234002818	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
458234002819	nucleotide binding site [chemical binding]; other site
458234002820	chaperone protein DnaJ; Provisional; Region: PRK10767
458234002821	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
458234002822	HSP70 interaction site [polypeptide binding]; other site
458234002823	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
458234002824	substrate binding site [polypeptide binding]; other site
458234002825	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
458234002826	Zn binding sites [ion binding]; other site
458234002827	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
458234002828	dimer interface [polypeptide binding]; other site
458234002829	Transcriptional regulator [Transcription]; Region: LysR; COG0583
458234002830	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
458234002831	putative effector binding pocket; other site
458234002832	dimerization interface [polypeptide binding]; other site
458234002833	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234002834	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234002835	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234002836	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234002837	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
458234002838	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
458234002839	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
458234002840	dimer interface [polypeptide binding]; other site
458234002841	motif 1; other site
458234002842	active site
458234002843	motif 2; other site
458234002844	motif 3; other site
458234002845	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
458234002846	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
458234002847	putative tRNA-binding site [nucleotide binding]; other site
458234002848	B3/4 domain; Region: B3_4; pfam03483
458234002849	tRNA synthetase B5 domain; Region: B5; smart00874
458234002850	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
458234002851	dimer interface [polypeptide binding]; other site
458234002852	motif 1; other site
458234002853	motif 3; other site
458234002854	motif 2; other site
458234002855	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
458234002856	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
458234002857	metal binding site 2 [ion binding]; metal-binding site
458234002858	putative DNA binding helix; other site
458234002859	metal binding site 1 [ion binding]; metal-binding site
458234002860	dimer interface [polypeptide binding]; other site
458234002861	structural Zn2+ binding site [ion binding]; other site
458234002862	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
458234002863	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
458234002864	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
458234002865	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
458234002866	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
458234002867	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
458234002868	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156
458234002869	putative active site [active]
458234002870	catalytic site [active]
458234002871	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162
458234002872	putative active site [active]
458234002873	catalytic site [active]
458234002874	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
458234002875	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156
458234002876	putative active site [active]
458234002877	catalytic site [active]
458234002878	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162
458234002879	putative active site [active]
458234002880	catalytic site [active]
458234002881	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
458234002882	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
458234002883	Walker A motif; other site
458234002884	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
458234002885	trimer interface [polypeptide binding]; other site
458234002886	active site
458234002887	Lipopolysaccharide-assembly; Region: LptE; cl01125
458234002888	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
458234002889	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
458234002890	HIGH motif; other site
458234002891	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
458234002892	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
458234002893	active site
458234002894	KMSKS motif; other site
458234002895	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
458234002896	tRNA binding surface [nucleotide binding]; other site
458234002897	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
458234002898	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
458234002899	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
458234002900	Transglutaminase/protease-like homologues; Region: TGc; smart00460
458234002901	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
458234002902	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
458234002903	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
458234002904	PAS fold; Region: PAS_4; pfam08448
458234002905	hypothetical protein; Provisional; Region: PRK07505
458234002906	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
458234002907	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
458234002908	catalytic residue [active]
458234002909	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
458234002910	Transcriptional regulators [Transcription]; Region: MarR; COG1846
458234002911	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
458234002912	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
458234002913	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
458234002914	catalytic residues [active]
458234002915	FeS assembly protein SufD; Region: sufD; TIGR01981
458234002916	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
458234002917	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
458234002918	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
458234002919	Walker A/P-loop; other site
458234002920	ATP binding site [chemical binding]; other site
458234002921	Q-loop/lid; other site
458234002922	ABC transporter signature motif; other site
458234002923	Walker B; other site
458234002924	D-loop; other site
458234002925	H-loop/switch region; other site
458234002926	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
458234002927	putative ABC transporter; Region: ycf24; CHL00085
458234002928	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
458234002929	Transcriptional regulator; Region: Rrf2; pfam02082
458234002930	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
458234002931	TrkA-N domain; Region: TrkA_N; pfam02254
458234002932	TrkA-N domain; Region: TrkA_N; pfam02254
458234002933	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
458234002934	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
458234002935	rRNA binding site [nucleotide binding]; other site
458234002936	predicted 30S ribosome binding site; other site
458234002937	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
458234002938	signal recognition particle protein; Provisional; Region: PRK10867
458234002939	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
458234002940	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
458234002941	P loop; other site
458234002942	GTP binding site [chemical binding]; other site
458234002943	Signal peptide binding domain; Region: SRP_SPB; pfam02978
458234002944	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
458234002945	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
458234002946	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234002947	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234002948	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234002949	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234002950	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
458234002951	active site
458234002952	Zn binding site [ion binding]; other site
458234002953	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
458234002954	putative active site [active]
458234002955	putative catalytic site [active]
458234002956	putative DNA binding site [nucleotide binding]; other site
458234002957	putative phosphate binding site [ion binding]; other site
458234002958	metal binding site A [ion binding]; metal-binding site
458234002959	putative AP binding site [nucleotide binding]; other site
458234002960	putative metal binding site B [ion binding]; other site
458234002961	short chain dehydrogenase; Provisional; Region: PRK07577
458234002962	classical (c) SDRs; Region: SDR_c; cd05233
458234002963	NAD(P) binding site [chemical binding]; other site
458234002964	active site
458234002965	AAA domain; Region: AAA_17; pfam13207
458234002966	AAA domain; Region: AAA_18; pfam13238
458234002967	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
458234002968	glutathione reductase; Validated; Region: PRK06116
458234002969	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
458234002970	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
458234002971	Uncharacterized conserved protein [Function unknown]; Region: COG0393
458234002972	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234002973	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234002974	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234002975	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
458234002976	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234002977	putative substrate translocation pore; other site
458234002978	POT family; Region: PTR2; cl17359
458234002979	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
458234002980	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
458234002981	ATP binding site [chemical binding]; other site
458234002982	Mg++ binding site [ion binding]; other site
458234002983	motif III; other site
458234002984	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
458234002985	nucleotide binding region [chemical binding]; other site
458234002986	ATP-binding site [chemical binding]; other site
458234002987	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
458234002988	GTP cyclohydrolase I; Provisional; Region: PLN03044
458234002989	active site
458234002990	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
458234002991	Glutamine amidotransferase class-I; Region: GATase; pfam00117
458234002992	glutamine binding [chemical binding]; other site
458234002993	catalytic triad [active]
458234002994	aminodeoxychorismate synthase; Provisional; Region: PRK07508
458234002995	chorismate binding enzyme; Region: Chorismate_bind; cl10555
458234002996	Aminotransferase class IV; Region: Aminotran_4; pfam01063
458234002997	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
458234002998	substrate-cofactor binding pocket; other site
458234002999	pyridoxal 5'-phosphate binding site [chemical binding]; other site
458234003000	catalytic residue [active]
458234003001	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
458234003002	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
458234003003	acyl-activating enzyme (AAE) consensus motif; other site
458234003004	AMP binding site [chemical binding]; other site
458234003005	active site
458234003006	CoA binding site [chemical binding]; other site
458234003007	Dihydroneopterin aldolase; Region: FolB; smart00905
458234003008	active site
458234003009	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
458234003010	catalytic center binding site [active]
458234003011	ATP binding site [chemical binding]; other site
458234003012	dihydropteroate synthase; Region: DHPS; TIGR01496
458234003013	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
458234003014	substrate binding pocket [chemical binding]; other site
458234003015	dimer interface [polypeptide binding]; other site
458234003016	inhibitor binding site; inhibition site
458234003017	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
458234003018	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
458234003019	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
458234003020	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
458234003021	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
458234003022	inhibitor-cofactor binding pocket; inhibition site
458234003023	pyridoxal 5'-phosphate binding site [chemical binding]; other site
458234003024	catalytic residue [active]
458234003025	biotin synthase; Region: bioB; TIGR00433
458234003026	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
458234003027	FeS/SAM binding site; other site
458234003028	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
458234003029	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
458234003030	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
458234003031	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
458234003032	catalytic residue [active]
458234003033	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
458234003034	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
458234003035	AAA domain; Region: AAA_26; pfam13500
458234003036	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
458234003037	dimerization interface [polypeptide binding]; other site
458234003038	putative DNA binding site [nucleotide binding]; other site
458234003039	putative Zn2+ binding site [ion binding]; other site
458234003040	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
458234003041	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
458234003042	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
458234003043	nucleotide binding site [chemical binding]; other site
458234003044	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
458234003045	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234003046	putative substrate translocation pore; other site
458234003047	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
458234003048	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
458234003049	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
458234003050	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
458234003051	inhibitor-cofactor binding pocket; inhibition site
458234003052	pyridoxal 5'-phosphate binding site [chemical binding]; other site
458234003053	catalytic residue [active]
458234003054	glutathione synthetase; Provisional; Region: PRK05246
458234003055	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
458234003056	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
458234003057	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
458234003058	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
458234003059	putative active site [active]
458234003060	substrate binding site [chemical binding]; other site
458234003061	putative cosubstrate binding site; other site
458234003062	catalytic site [active]
458234003063	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
458234003064	substrate binding site [chemical binding]; other site
458234003065	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
458234003066	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
458234003067	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
458234003068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
458234003069	S-adenosylmethionine binding site [chemical binding]; other site
458234003070	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
458234003071	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
458234003072	active site
458234003073	nucleic acid binding site [nucleotide binding]; other site
458234003074	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234003075	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234003076	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234003077	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234003078	HI0933-like protein; Region: HI0933_like; pfam03486
458234003079	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
458234003080	short chain dehydrogenase; Provisional; Region: PRK05993
458234003081	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
458234003082	NADP binding site [chemical binding]; other site
458234003083	active site
458234003084	steroid binding site; other site
458234003085	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234003086	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234003087	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234003088	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234003089	SnoaL-like domain; Region: SnoaL_2; pfam12680
458234003090	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
458234003091	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
458234003092	ferredoxin-NADP reductase; Provisional; Region: PRK10926
458234003093	FAD binding pocket [chemical binding]; other site
458234003094	FAD binding motif [chemical binding]; other site
458234003095	phosphate binding motif [ion binding]; other site
458234003096	beta-alpha-beta structure motif; other site
458234003097	NAD binding pocket [chemical binding]; other site
458234003098	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
458234003099	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
458234003100	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
458234003101	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
458234003102	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
458234003103	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
458234003104	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
458234003105	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
458234003106	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
458234003107	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
458234003108	active site
458234003109	multimer interface [polypeptide binding]; other site
458234003110	CTP synthetase; Validated; Region: pyrG; PRK05380
458234003111	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
458234003112	Catalytic site [active]
458234003113	active site
458234003114	UTP binding site [chemical binding]; other site
458234003115	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
458234003116	active site
458234003117	putative oxyanion hole; other site
458234003118	catalytic triad [active]
458234003119	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234003120	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234003121	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234003122	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234003123	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
458234003124	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
458234003125	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
458234003126	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
458234003127	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
458234003128	ligand binding site [chemical binding]; other site
458234003129	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
458234003130	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
458234003131	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
458234003132	active site
458234003133	(T/H)XGH motif; other site
458234003134	probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406
458234003135	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
458234003136	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
458234003137	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
458234003138	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
458234003139	catalytic residue [active]
458234003140	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
458234003141	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
458234003142	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
458234003143	Protein of unknown function DUF45; Region: DUF45; pfam01863
458234003144	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
458234003145	Prephenate dehydratase; Region: PDT; pfam00800
458234003146	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
458234003147	putative L-Phe binding site [chemical binding]; other site
458234003148	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
458234003149	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
458234003150	active site
458234003151	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
458234003152	dimer interface [polypeptide binding]; other site
458234003153	substrate binding site [chemical binding]; other site
458234003154	catalytic residues [active]
458234003155	GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080
458234003156	putative C-terminal domain interface [polypeptide binding]; other site
458234003157	putative GSH binding site [chemical binding]; other site
458234003158	putative dimer interface [polypeptide binding]; other site
458234003159	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
458234003160	dimer interface [polypeptide binding]; other site
458234003161	substrate binding pocket (H-site) [chemical binding]; other site
458234003162	C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193
458234003163	putative N-terminal domain interface [polypeptide binding]; other site
458234003164	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
458234003165	hypothetical protein; Provisional; Region: PRK14013
458234003166	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234003167	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234003168	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234003169	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
458234003170	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
458234003171	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
458234003172	active site
458234003173	recombination protein F; Reviewed; Region: recF; PRK00064
458234003174	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
458234003175	Walker A/P-loop; other site
458234003176	ATP binding site [chemical binding]; other site
458234003177	Q-loop/lid; other site
458234003178	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
458234003179	ABC transporter signature motif; other site
458234003180	Walker B; other site
458234003181	D-loop; other site
458234003182	H-loop/switch region; other site
458234003183	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
458234003184	EamA-like transporter family; Region: EamA; pfam00892
458234003185	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
458234003186	EamA-like transporter family; Region: EamA; pfam00892
458234003187	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
458234003188	active site
458234003189	CoA binding site [chemical binding]; other site
458234003190	AMP binding site [chemical binding]; other site
458234003191	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
458234003192	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
458234003193	active site
458234003194	tetramer interface; other site
458234003195	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
458234003196	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
458234003197	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
458234003198	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
458234003199	DNA-binding site [nucleotide binding]; DNA binding site
458234003200	RNA-binding motif; other site
458234003201	Radical SAM superfamily; Region: Radical_SAM; pfam04055
458234003202	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
458234003203	FeS/SAM binding site; other site
458234003204	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
458234003205	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
458234003206	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
458234003207	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
458234003208	non-specific DNA interactions [nucleotide binding]; other site
458234003209	DNA binding site [nucleotide binding]
458234003210	sequence specific DNA binding site [nucleotide binding]; other site
458234003211	putative cAMP binding site [chemical binding]; other site
458234003212	Bacterial transcriptional regulator; Region: IclR; pfam01614
458234003213	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234003214	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234003215	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234003216	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234003217	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
458234003218	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
458234003219	RNA binding surface [nucleotide binding]; other site
458234003220	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
458234003221	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
458234003222	putative substrate binding site [chemical binding]; other site
458234003223	putative ATP binding site [chemical binding]; other site
458234003224	Putative serine esterase (DUF676); Region: DUF676; pfam05057
458234003225	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
458234003226	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
458234003227	catalytic residues [active]
458234003228	dimer interface [polypeptide binding]; other site
458234003229	Chorismate mutase type II; Region: CM_2; smart00830
458234003230	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234003231	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234003232	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234003233	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
458234003234	L-aspartate oxidase; Provisional; Region: PRK06175
458234003235	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
458234003236	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
458234003237	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
458234003238	dimerization interface [polypeptide binding]; other site
458234003239	active site
458234003240	quinolinate synthetase; Provisional; Region: PRK09375
458234003241	Guanylate kinase; Region: Guanylate_kin; pfam00625
458234003242	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
458234003243	catalytic site [active]
458234003244	G-X2-G-X-G-K; other site
458234003245	helicase 45; Provisional; Region: PTZ00424
458234003246	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
458234003247	ATP binding site [chemical binding]; other site
458234003248	Mg++ binding site [ion binding]; other site
458234003249	motif III; other site
458234003250	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
458234003251	nucleotide binding region [chemical binding]; other site
458234003252	ATP-binding site [chemical binding]; other site
458234003253	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
458234003254	putative RNA binding site [nucleotide binding]; other site
458234003255	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
458234003256	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
458234003257	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
458234003258	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234003259	putative substrate translocation pore; other site
458234003260	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
458234003261	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234003262	putative substrate translocation pore; other site
458234003263	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234003264	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
458234003265	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
458234003266	dimer interface [polypeptide binding]; other site
458234003267	active site
458234003268	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
458234003269	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
458234003270	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
458234003271	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
458234003272	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
458234003273	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
458234003274	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
458234003275	Ligand binding site; other site
458234003276	oligomer interface; other site
458234003277	Uncharacterized conserved protein [Function unknown]; Region: COG2835
458234003278	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234003279	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234003280	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234003281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234003282	Uncharacterized conserved protein [Function unknown]; Region: COG0398
458234003283	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
458234003284	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
458234003285	23S rRNA binding site [nucleotide binding]; other site
458234003286	L21 binding site [polypeptide binding]; other site
458234003287	L13 binding site [polypeptide binding]; other site
458234003288	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
458234003289	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
458234003290	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
458234003291	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
458234003292	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
458234003293	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
458234003294	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
458234003295	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
458234003296	active site
458234003297	dimer interface [polypeptide binding]; other site
458234003298	motif 1; other site
458234003299	motif 2; other site
458234003300	motif 3; other site
458234003301	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
458234003302	anticodon binding site; other site
458234003303	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
458234003304	lipoyl attachment site [posttranslational modification]; other site
458234003305	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
458234003306	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
458234003307	homodimer interface [polypeptide binding]; other site
458234003308	active site
458234003309	hypothetical protein; Validated; Region: PRK00153
458234003310	recombination protein RecR; Provisional; Region: PRK13844
458234003311	RecR protein; Region: RecR; pfam02132
458234003312	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
458234003313	putative active site [active]
458234003314	putative metal-binding site [ion binding]; other site
458234003315	tetramer interface [polypeptide binding]; other site
458234003316	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
458234003317	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
458234003318	Zn2+ binding site [ion binding]; other site
458234003319	Mg2+ binding site [ion binding]; other site
458234003320	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
458234003321	synthetase active site [active]
458234003322	NTP binding site [chemical binding]; other site
458234003323	metal binding site [ion binding]; metal-binding site
458234003324	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
458234003325	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
458234003326	poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332
458234003327	poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011
458234003328	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
458234003329	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
458234003330	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234003331	metabolite-proton symporter; Region: 2A0106; TIGR00883
458234003332	putative substrate translocation pore; other site
458234003333	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
458234003334	catalytic nucleophile [active]
458234003335	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
458234003336	proposed catalytic triad [active]
458234003337	active site nucleophile [active]
458234003338	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
458234003339	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
458234003340	substrate binding site [chemical binding]; other site
458234003341	ATP binding site [chemical binding]; other site
458234003342	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
458234003343	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
458234003344	motif II; other site
458234003345	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
458234003346	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
458234003347	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
458234003348	active site
458234003349	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
458234003350	active site
458234003351	LicD family; Region: LicD; pfam04991
458234003352	Methyltransferase domain; Region: Methyltransf_23; pfam13489
458234003353	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
458234003354	S-adenosylmethionine binding site [chemical binding]; other site
458234003355	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
458234003356	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
458234003357	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
458234003358	active site
458234003359	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
458234003360	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
458234003361	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
458234003362	Walker A/P-loop; other site
458234003363	ATP binding site [chemical binding]; other site
458234003364	Q-loop/lid; other site
458234003365	ABC transporter signature motif; other site
458234003366	Walker B; other site
458234003367	D-loop; other site
458234003368	H-loop/switch region; other site
458234003369	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
458234003370	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
458234003371	putative ADP-binding pocket [chemical binding]; other site
458234003372	UDP-glucose 4-epimerase; Region: PLN02240
458234003373	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
458234003374	NAD binding site [chemical binding]; other site
458234003375	homodimer interface [polypeptide binding]; other site
458234003376	active site
458234003377	substrate binding site [chemical binding]; other site
458234003378	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
458234003379	Bacterial sugar transferase; Region: Bac_transf; pfam02397
458234003380	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
458234003381	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
458234003382	substrate binding site [chemical binding]; other site
458234003383	hexamer interface [polypeptide binding]; other site
458234003384	metal binding site [ion binding]; metal-binding site
458234003385	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
458234003386	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
458234003387	putative active site [active]
458234003388	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
458234003389	DoxX; Region: DoxX; pfam07681
458234003390	hypothetical protein; Provisional; Region: PRK05409
458234003391	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234003392	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234003393	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234003394	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
458234003395	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
458234003396	NAD binding site [chemical binding]; other site
458234003397	homotetramer interface [polypeptide binding]; other site
458234003398	homodimer interface [polypeptide binding]; other site
458234003399	substrate binding site [chemical binding]; other site
458234003400	active site
458234003401	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
458234003402	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234003403	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234003404	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234003405	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234003406	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234003407	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234003408	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234003409	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
458234003410	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
458234003411	GIY-YIG motif/motif A; other site
458234003412	active site
458234003413	catalytic site [active]
458234003414	putative DNA binding site [nucleotide binding]; other site
458234003415	metal binding site [ion binding]; metal-binding site
458234003416	UvrB/uvrC motif; Region: UVR; pfam02151
458234003417	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
458234003418	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
458234003419	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
458234003420	catalytic site [active]
458234003421	putative active site [active]
458234003422	putative substrate binding site [chemical binding]; other site
458234003423	HRDC domain; Region: HRDC; pfam00570
458234003424	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
458234003425	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234003426	putative substrate translocation pore; other site
458234003427	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
458234003428	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
458234003429	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
458234003430	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
458234003431	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
458234003432	ATP binding site [chemical binding]; other site
458234003433	putative Mg++ binding site [ion binding]; other site
458234003434	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
458234003435	SEC-C motif; Region: SEC-C; pfam02810
458234003436	LPP20 lipoprotein; Region: LPP20; cl15824
458234003437	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
458234003438	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234003439	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234003440	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234003441	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234003442	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234003443	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234003444	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234003445	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
458234003446	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
458234003447	Walker A motif; other site
458234003448	ATP binding site [chemical binding]; other site
458234003449	Walker B motif; other site
458234003450	arginine finger; other site
458234003451	Peptidase family M41; Region: Peptidase_M41; pfam01434
458234003452	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234003453	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234003454	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234003455	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
458234003456	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
458234003457	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
458234003458	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
458234003459	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
458234003460	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
458234003461	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
458234003462	Type II transport protein GspH; Region: GspH; pfam12019
458234003463	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
458234003464	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
458234003465	active site
458234003466	dimer interface [polypeptide binding]; other site
458234003467	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
458234003468	dimer interface [polypeptide binding]; other site
458234003469	active site
458234003470	Thiamine pyrophosphokinase; Region: TPK; cd07995
458234003471	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
458234003472	active site
458234003473	dimerization interface [polypeptide binding]; other site
458234003474	thiamine binding site [chemical binding]; other site
458234003475	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
458234003476	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
458234003477	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
458234003478	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
458234003479	active site
458234003480	multifunctional aminopeptidase A; Provisional; Region: PRK00913
458234003481	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
458234003482	interface (dimer of trimers) [polypeptide binding]; other site
458234003483	Substrate-binding/catalytic site; other site
458234003484	Zn-binding sites [ion binding]; other site
458234003485	Predicted permeases [General function prediction only]; Region: COG0795
458234003486	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
458234003487	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
458234003488	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
458234003489	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
458234003490	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
458234003491	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
458234003492	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
458234003493	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
458234003494	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
458234003495	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
458234003496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
458234003497	Predicted membrane protein [Function unknown]; Region: COG2860
458234003498	UPF0126 domain; Region: UPF0126; pfam03458
458234003499	UPF0126 domain; Region: UPF0126; pfam03458
458234003500	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
458234003501	active site
458234003502	dinuclear metal binding site [ion binding]; other site
458234003503	dimerization interface [polypeptide binding]; other site
458234003504	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
458234003505	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
458234003506	active site
458234003507	catalytic motif [active]
458234003508	Zn binding site [ion binding]; other site
458234003509	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
458234003510	FAD binding domain; Region: FAD_binding_4; pfam01565
458234003511	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
458234003512	phosphoglyceromutase; Provisional; Region: PRK05434
458234003513	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
458234003514	seryl-tRNA synthetase; Provisional; Region: PRK05431
458234003515	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
458234003516	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
458234003517	dimer interface [polypeptide binding]; other site
458234003518	active site
458234003519	motif 1; other site
458234003520	motif 2; other site
458234003521	motif 3; other site
458234003522	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
458234003523	ROK family; Region: ROK; pfam00480
458234003524	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
458234003525	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
458234003526	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
458234003527	Walker A/P-loop; other site
458234003528	ATP binding site [chemical binding]; other site
458234003529	Q-loop/lid; other site
458234003530	ABC transporter signature motif; other site
458234003531	Walker B; other site
458234003532	D-loop; other site
458234003533	H-loop/switch region; other site
458234003534	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
458234003535	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
458234003536	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
458234003537	Walker A/P-loop; other site
458234003538	ATP binding site [chemical binding]; other site
458234003539	Q-loop/lid; other site
458234003540	ABC transporter signature motif; other site
458234003541	Walker B; other site
458234003542	D-loop; other site
458234003543	H-loop/switch region; other site
458234003544	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
458234003545	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
458234003546	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
458234003547	homotrimer interaction site [polypeptide binding]; other site
458234003548	putative active site [active]
458234003549	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
458234003550	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
458234003551	Sulfate transporter family; Region: Sulfate_transp; pfam00916
458234003552	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
458234003553	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234003554	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234003555	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234003556	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234003557	metabolite-proton symporter; Region: 2A0106; TIGR00883
458234003558	putative substrate translocation pore; other site
458234003559	dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232
458234003560	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
458234003561	Zn2+ binding site [ion binding]; other site
458234003562	Mg2+ binding site [ion binding]; other site
458234003563	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
458234003564	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
458234003565	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
458234003566	heme binding site [chemical binding]; other site
458234003567	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
458234003568	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234003569	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234003570	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234003571	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234003572	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
458234003573	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234003574	putative substrate translocation pore; other site
458234003575	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
458234003576	Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567
458234003577	active site
458234003578	catalytic site [active]
458234003579	metal binding site [ion binding]; metal-binding site
458234003580	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
458234003581	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
458234003582	Walker A/P-loop; other site
458234003583	ATP binding site [chemical binding]; other site
458234003584	Q-loop/lid; other site
458234003585	ABC transporter signature motif; other site
458234003586	Walker B; other site
458234003587	D-loop; other site
458234003588	H-loop/switch region; other site
458234003589	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234003590	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234003591	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234003592	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
458234003593	putative substrate binding pocket [chemical binding]; other site
458234003594	trimer interface [polypeptide binding]; other site
458234003595	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
458234003596	active site
458234003597	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
458234003598	Glyco_18 domain; Region: Glyco_18; smart00636
458234003599	active site
458234003600	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
458234003601	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
458234003602	aromatic chitin/cellulose binding site residues [chemical binding]; other site
458234003603	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
458234003604	aromatic chitin/cellulose binding site residues [chemical binding]; other site
458234003605	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
458234003606	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
458234003607	substrate-cofactor binding pocket; other site
458234003608	pyridoxal 5'-phosphate binding site [chemical binding]; other site
458234003609	catalytic residue [active]
458234003610	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
458234003611	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
458234003612	NAD(P) binding site [chemical binding]; other site
458234003613	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
458234003614	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
458234003615	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
458234003616	substrate binding site; other site
458234003617	dimer interface; other site
458234003618	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
458234003619	Septum formation initiator; Region: DivIC; cl17659
458234003620	enolase; Provisional; Region: eno; PRK00077
458234003621	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
458234003622	dimer interface [polypeptide binding]; other site
458234003623	metal binding site [ion binding]; metal-binding site
458234003624	substrate binding pocket [chemical binding]; other site
458234003625	Major Facilitator Superfamily; Region: MFS_1; pfam07690
458234003626	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234003627	putative substrate translocation pore; other site
458234003628	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
458234003629	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; pfam00370
458234003630	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
458234003631	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
458234003632	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
458234003633	TRAM domain; Region: TRAM; pfam01938
458234003634	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
458234003635	S-adenosylmethionine binding site [chemical binding]; other site
458234003636	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
458234003637	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
458234003638	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
458234003639	ATP-binding site [chemical binding]; other site
458234003640	Sugar specificity; other site
458234003641	Pyrimidine base specificity; other site
458234003642	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
458234003643	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
458234003644	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
458234003645	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
458234003646	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
458234003647	oligomer interface [polypeptide binding]; other site
458234003648	RNA binding site [nucleotide binding]; other site
458234003649	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
458234003650	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
458234003651	RNase E interface [polypeptide binding]; other site
458234003652	trimer interface [polypeptide binding]; other site
458234003653	active site
458234003654	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
458234003655	putative nucleic acid binding region [nucleotide binding]; other site
458234003656	G-X-X-G motif; other site
458234003657	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
458234003658	RNA binding site [nucleotide binding]; other site
458234003659	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
458234003660	16S/18S rRNA binding site [nucleotide binding]; other site
458234003661	S13e-L30e interaction site [polypeptide binding]; other site
458234003662	25S rRNA binding site [nucleotide binding]; other site
458234003663	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
458234003664	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
458234003665	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
458234003666	Cell division protein FtsL; Region: FtsL; cl11433
458234003667	MraW methylase family; Region: Methyltransf_5; cl17771
458234003668	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
458234003669	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
458234003670	AMP-binding enzyme; Region: AMP-binding; pfam00501
458234003671	acyl-activating enzyme (AAE) consensus motif; other site
458234003672	putative AMP binding site [chemical binding]; other site
458234003673	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
458234003674	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
458234003675	DNA binding site [nucleotide binding]
458234003676	catalytic residue [active]
458234003677	H2TH interface [polypeptide binding]; other site
458234003678	putative catalytic residues [active]
458234003679	turnover-facilitating residue; other site
458234003680	intercalation triad [nucleotide binding]; other site
458234003681	8OG recognition residue [nucleotide binding]; other site
458234003682	putative reading head residues; other site
458234003683	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
458234003684	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
458234003685	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234003686	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234003687	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234003688	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234003689	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
458234003690	predicted active site [active]
458234003691	catalytic triad [active]
458234003692	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
458234003693	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
458234003694	active site
458234003695	multimer interface [polypeptide binding]; other site
458234003696	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
458234003697	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
458234003698	ATP binding site [chemical binding]; other site
458234003699	Mg2+ binding site [ion binding]; other site
458234003700	G-X-G motif; other site
458234003701	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
458234003702	anchoring element; other site
458234003703	dimer interface [polypeptide binding]; other site
458234003704	ATP binding site [chemical binding]; other site
458234003705	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
458234003706	active site
458234003707	putative metal-binding site [ion binding]; other site
458234003708	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
458234003709	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
458234003710	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
458234003711	FMN binding site [chemical binding]; other site
458234003712	active site
458234003713	catalytic residues [active]
458234003714	substrate binding site [chemical binding]; other site
458234003715	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
458234003716	TIGR03546 family protein; Region: TIGR03546
458234003717	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
458234003718	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
458234003719	CoA-ligase; Region: Ligase_CoA; pfam00549
458234003720	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
458234003721	CoA binding domain; Region: CoA_binding; smart00881
458234003722	CoA-ligase; Region: Ligase_CoA; pfam00549
458234003723	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513
458234003724	active site
458234003725	dimer interface [polypeptide binding]; other site
458234003726	catalytic nucleophile [active]
458234003727	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
458234003728	MFS transport protein AraJ; Provisional; Region: PRK10091
458234003729	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234003730	putative substrate translocation pore; other site
458234003731	Transcriptional regulator [Transcription]; Region: LysR; COG0583
458234003732	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
458234003733	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
458234003734	putative effector binding pocket; other site
458234003735	dimerization interface [polypeptide binding]; other site
458234003736	phosphoglycolate phosphatase; Provisional; Region: PRK13222
458234003737	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
458234003738	motif II; other site
458234003739	thioredoxin reductase; Provisional; Region: PRK10262
458234003740	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
458234003741	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
458234003742	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234003743	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234003744	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234003745	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
458234003746	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
458234003747	ATP binding site [chemical binding]; other site
458234003748	Mg2+ binding site [ion binding]; other site
458234003749	G-X-G motif; other site
458234003750	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
458234003751	ATP binding site [chemical binding]; other site
458234003752	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
458234003753	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
458234003754	Predicted GTPases [General function prediction only]; Region: COG1162
458234003755	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
458234003756	RNA binding site [nucleotide binding]; other site
458234003757	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
458234003758	GTPase/Zn-binding domain interface [polypeptide binding]; other site
458234003759	GTP/Mg2+ binding site [chemical binding]; other site
458234003760	G4 box; other site
458234003761	G5 box; other site
458234003762	G1 box; other site
458234003763	Switch I region; other site
458234003764	G2 box; other site
458234003765	G3 box; other site
458234003766	Switch II region; other site
458234003767	Protein of unknown function (DUF3281); Region: DUF3281; pfam11685
458234003768	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
458234003769	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
458234003770	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
458234003771	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
458234003772	Domain of unknown function DUF20; Region: UPF0118; pfam01594
458234003773	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
458234003774	DHH family; Region: DHH; pfam01368
458234003775	DHHA1 domain; Region: DHHA1; pfam02272
458234003776	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
458234003777	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
458234003778	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
458234003779	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
458234003780	motif 1; other site
458234003781	dimer interface [polypeptide binding]; other site
458234003782	active site
458234003783	motif 2; other site
458234003784	motif 3; other site
458234003785	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234003786	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234003787	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234003788	Helix-turn-helix domain; Region: HTH_25; pfam13413
458234003789	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
458234003790	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
458234003791	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
458234003792	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
458234003793	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
458234003794	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
458234003795	carboxyltransferase (CT) interaction site; other site
458234003796	biotinylation site [posttranslational modification]; other site
458234003797	Dehydroquinase class II; Region: DHquinase_II; pfam01220
458234003798	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
458234003799	trimer interface [polypeptide binding]; other site
458234003800	active site
458234003801	dimer interface [polypeptide binding]; other site
458234003802	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
458234003803	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
458234003804	active site
458234003805	metal binding site [ion binding]; metal-binding site
458234003806	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
458234003807	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
458234003808	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
458234003809	SurA N-terminal domain; Region: SurA_N; pfam09312
458234003810	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
458234003811	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
458234003812	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
458234003813	Organic solvent tolerance protein; Region: OstA_C; pfam04453
458234003814	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
458234003815	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
458234003816	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
458234003817	active site
458234003818	HIGH motif; other site
458234003819	nucleotide binding site [chemical binding]; other site
458234003820	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
458234003821	KMSK motif region; other site
458234003822	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
458234003823	tRNA binding surface [nucleotide binding]; other site
458234003824	anticodon binding site; other site
458234003825	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
458234003826	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
458234003827	dimer interface [polypeptide binding]; other site
458234003828	active site
458234003829	Schiff base residues; other site
458234003830	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
458234003831	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
458234003832	DNA polymerase III subunit delta'; Validated; Region: PRK08485
458234003833	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
458234003834	putative inner membrane peptidase; Provisional; Region: PRK11778
458234003835	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
458234003836	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
458234003837	tandem repeat interface [polypeptide binding]; other site
458234003838	oligomer interface [polypeptide binding]; other site
458234003839	active site residues [active]
458234003840	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
458234003841	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
458234003842	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
458234003843	dimer interface [polypeptide binding]; other site
458234003844	N-terminal domain interface [polypeptide binding]; other site
458234003845	DsrC like protein; Region: DsrC; pfam04358
458234003846	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
458234003847	oxidative damage protection protein; Provisional; Region: PRK05408
458234003848	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
458234003849	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
458234003850	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234003851	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234003852	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234003853	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234003854	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
458234003855	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
458234003856	Ligand binding site; other site
458234003857	Putative Catalytic site; other site
458234003858	DXD motif; other site
458234003859	Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712
458234003860	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
458234003861	putative active site [active]
458234003862	YdjC motif; other site
458234003863	Mg binding site [ion binding]; other site
458234003864	putative homodimer interface [polypeptide binding]; other site
458234003865	cell division protein FtsW; Region: ftsW; TIGR02614
458234003866	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
458234003867	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
458234003868	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
458234003869	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
458234003870	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
458234003871	Mg++ binding site [ion binding]; other site
458234003872	putative catalytic motif [active]
458234003873	putative substrate binding site [chemical binding]; other site
458234003874	phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344
458234003875	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
458234003876	active site
458234003877	metal-binding site [ion binding]
458234003878	nucleotide-binding site [chemical binding]; other site
458234003879	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
458234003880	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
458234003881	active site
458234003882	HIGH motif; other site
458234003883	nucleotide binding site [chemical binding]; other site
458234003884	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
458234003885	KMSKS motif; other site
458234003886	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
458234003887	POT family; Region: PTR2; cl17359
458234003888	ABC transporter ATPase component; Reviewed; Region: PRK11147
458234003889	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
458234003890	Walker A/P-loop; other site
458234003891	ATP binding site [chemical binding]; other site
458234003892	Q-loop/lid; other site
458234003893	ABC transporter signature motif; other site
458234003894	Walker B; other site
458234003895	D-loop; other site
458234003896	H-loop/switch region; other site
458234003897	ABC transporter; Region: ABC_tran_2; pfam12848
458234003898	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
458234003899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234003900	Major Facilitator Superfamily; Region: MFS_1; pfam07690
458234003901	putative substrate translocation pore; other site
458234003902	Predicted membrane protein [Function unknown]; Region: COG4129
458234003903	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
458234003904	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
458234003905	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
458234003906	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234003907	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234003908	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234003909	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234003910	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234003911	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234003912	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234003913	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234003914	Transcriptional regulator [Transcription]; Region: LysR; COG0583
458234003915	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
458234003916	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
458234003917	dimerization interface [polypeptide binding]; other site
458234003918	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
458234003919	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
458234003920	S-adenosylmethionine binding site [chemical binding]; other site
458234003921	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
458234003922	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
458234003923	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234003924	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234003925	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234003926	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234003927	glycerol kinase; Provisional; Region: glpK; PRK00047
458234003928	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
458234003929	N- and C-terminal domain interface [polypeptide binding]; other site
458234003930	active site
458234003931	MgATP binding site [chemical binding]; other site
458234003932	catalytic site [active]
458234003933	metal binding site [ion binding]; metal-binding site
458234003934	glycerol binding site [chemical binding]; other site
458234003935	homotetramer interface [polypeptide binding]; other site
458234003936	homodimer interface [polypeptide binding]; other site
458234003937	FBP binding site [chemical binding]; other site
458234003938	protein IIAGlc interface [polypeptide binding]; other site
458234003939	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234003940	putative substrate translocation pore; other site
458234003941	Major Facilitator Superfamily; Region: MFS_1; pfam07690
458234003942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234003943	Major Facilitator Superfamily; Region: MFS_1; pfam07690
458234003944	putative substrate translocation pore; other site
458234003945	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
458234003946	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
458234003947	Walker A/P-loop; other site
458234003948	ATP binding site [chemical binding]; other site
458234003949	Q-loop/lid; other site
458234003950	ABC transporter signature motif; other site
458234003951	Walker B; other site
458234003952	D-loop; other site
458234003953	H-loop/switch region; other site
458234003954	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
458234003955	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234003956	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234003957	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234003958	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
458234003959	Part of AAA domain; Region: AAA_19; pfam13245
458234003960	Family description; Region: UvrD_C_2; pfam13538
458234003961	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
458234003962	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
458234003963	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
458234003964	GTP binding site [chemical binding]; other site
458234003965	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
458234003966	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
458234003967	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
458234003968	G1 box; other site
458234003969	putative GEF interaction site [polypeptide binding]; other site
458234003970	GTP/Mg2+ binding site [chemical binding]; other site
458234003971	Switch I region; other site
458234003972	G2 box; other site
458234003973	G3 box; other site
458234003974	Switch II region; other site
458234003975	G4 box; other site
458234003976	G5 box; other site
458234003977	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
458234003978	thymidylate kinase; Validated; Region: tmk; PRK00698
458234003979	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
458234003980	TMP-binding site; other site
458234003981	ATP-binding site [chemical binding]; other site
458234003982	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
458234003983	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
458234003984	Nucleoside recognition; Region: Gate; pfam07670
458234003985	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
458234003986	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
458234003987	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
458234003988	Nucleoside recognition; Region: Gate; pfam07670
458234003989	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
458234003990	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
458234003991	intersubunit interface [polypeptide binding]; other site
458234003992	active site
458234003993	catalytic residue [active]
458234003994	phosphopentomutase; Provisional; Region: PRK05362
458234003995	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
458234003996	pantothenate kinase; Reviewed; Region: PRK13324
458234003997	DNA polymerase I; Provisional; Region: PRK05755
458234003998	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
458234003999	active site
458234004000	metal binding site 1 [ion binding]; metal-binding site
458234004001	putative 5' ssDNA interaction site; other site
458234004002	metal binding site 3; metal-binding site
458234004003	metal binding site 2 [ion binding]; metal-binding site
458234004004	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
458234004005	putative DNA binding site [nucleotide binding]; other site
458234004006	putative metal binding site [ion binding]; other site
458234004007	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
458234004008	active site
458234004009	catalytic site [active]
458234004010	substrate binding site [chemical binding]; other site
458234004011	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
458234004012	active site
458234004013	DNA binding site [nucleotide binding]
458234004014	catalytic site [active]
458234004015	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
458234004016	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
458234004017	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296
458234004018	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
458234004019	active site
458234004020	NTP binding site [chemical binding]; other site
458234004021	metal binding triad [ion binding]; metal-binding site
458234004022	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
458234004023	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
458234004024	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
458234004025	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
458234004026	HlyD family secretion protein; Region: HlyD_3; pfam13437
458234004027	multidrug efflux protein; Reviewed; Region: PRK09579
458234004028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234004029	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
458234004030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234004031	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
458234004032	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
458234004033	dimer interface [polypeptide binding]; other site
458234004034	catalytic triad [active]
458234004035	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
458234004036	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234004037	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234004038	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234004039	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234004040	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234004041	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234004042	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234004043	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
458234004044	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
458234004045	active site
458234004046	HIGH motif; other site
458234004047	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
458234004048	KMSKS motif; other site
458234004049	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
458234004050	tRNA binding surface [nucleotide binding]; other site
458234004051	anticodon binding site; other site
458234004052	HemK family putative methylases; Region: hemK_fam; TIGR00536
458234004053	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
458234004054	S-adenosylmethionine binding site [chemical binding]; other site
458234004055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234004056	Major Facilitator Superfamily; Region: MFS_1; pfam07690
458234004057	putative substrate translocation pore; other site
458234004058	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
458234004059	Coenzyme A binding pocket [chemical binding]; other site
458234004060	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234004061	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234004062	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234004063	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234004064	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
458234004065	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
458234004066	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
458234004067	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
458234004068	DXD motif; other site
458234004069	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
458234004070	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
458234004071	putative active site [active]
458234004072	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
458234004073	lysine transporter; Provisional; Region: PRK10836
458234004074	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
458234004075	active site
458234004076	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
458234004077	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
458234004078	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
458234004079	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
458234004080	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
458234004081	Cation transport protein; Region: TrkH; cl17365
458234004082	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
458234004083	ProQ/FINO family; Region: ProQ; smart00945
458234004084	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234004085	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234004086	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234004087	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234004088	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
458234004089	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
458234004090	ring oligomerisation interface [polypeptide binding]; other site
458234004091	ATP/Mg binding site [chemical binding]; other site
458234004092	stacking interactions; other site
458234004093	hinge regions; other site
458234004094	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
458234004095	oligomerisation interface [polypeptide binding]; other site
458234004096	mobile loop; other site
458234004097	roof hairpin; other site
458234004098	Predicted membrane protein [Function unknown]; Region: COG4125
458234004099	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
458234004100	hypothetical protein; Validated; Region: PRK02101
458234004101	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234004102	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234004103	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234004104	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234004105	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
458234004106	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
458234004107	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
458234004108	peptide chain release factor 1; Validated; Region: prfA; PRK00591
458234004109	This domain is found in peptide chain release factors; Region: PCRF; smart00937
458234004110	RF-1 domain; Region: RF-1; pfam00472
458234004111	glutamyl-tRNA reductase; Provisional; Region: PRK13940
458234004112	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
458234004113	tRNA; other site
458234004114	putative tRNA binding site [nucleotide binding]; other site
458234004115	putative NADP binding site [chemical binding]; other site
458234004116	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
458234004117	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
458234004118	TPR motif; other site
458234004119	binding surface
458234004120	Tetratricopeptide repeat; Region: TPR_16; pfam13432
458234004121	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
458234004122	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
458234004123	Trp docking motif [polypeptide binding]; other site
458234004124	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234004125	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
458234004126	putative substrate translocation pore; other site
458234004127	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
458234004128	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
458234004129	Mg2+ binding site [ion binding]; other site
458234004130	G-X-G motif; other site
458234004131	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
458234004132	anchoring element; other site
458234004133	dimer interface [polypeptide binding]; other site
458234004134	ATP binding site [chemical binding]; other site
458234004135	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
458234004136	active site
458234004137	metal binding site [ion binding]; metal-binding site
458234004138	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
458234004139	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
458234004140	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
458234004141	amidase catalytic site [active]
458234004142	Zn binding residues [ion binding]; other site
458234004143	substrate binding site [chemical binding]; other site
458234004144	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
458234004145	active site
458234004146	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
458234004147	putative active site [active]
458234004148	Ap4A binding site [chemical binding]; other site
458234004149	nudix motif; other site
458234004150	putative metal binding site [ion binding]; other site
458234004151	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
458234004152	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
458234004153	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
458234004154	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
458234004155	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
458234004156	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
458234004157	active site
458234004158	DNA binding site [nucleotide binding]
458234004159	Int/Topo IB signature motif; other site
458234004160	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
458234004161	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
458234004162	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591
458234004163	RimM N-terminal domain; Region: RimM; pfam01782
458234004164	PRC-barrel domain; Region: PRC; pfam05239
458234004165	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
458234004166	S-adenosylmethionine synthetase; Validated; Region: PRK05250
458234004167	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
458234004168	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
458234004169	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
458234004170	Fatty acid desaturase; Region: FA_desaturase; pfam00487
458234004171	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
458234004172	Di-iron ligands [ion binding]; other site
458234004173	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
458234004174	UGMP family protein; Validated; Region: PRK09604
458234004175	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
458234004176	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
458234004177	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
458234004178	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
458234004179	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
458234004180	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
458234004181	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
458234004182	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
458234004183	RPB3 interaction site [polypeptide binding]; other site
458234004184	RPB1 interaction site [polypeptide binding]; other site
458234004185	RPB11 interaction site [polypeptide binding]; other site
458234004186	RPB10 interaction site [polypeptide binding]; other site
458234004187	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
458234004188	core dimer interface [polypeptide binding]; other site
458234004189	peripheral dimer interface [polypeptide binding]; other site
458234004190	L10 interface [polypeptide binding]; other site
458234004191	L11 interface [polypeptide binding]; other site
458234004192	putative EF-Tu interaction site [polypeptide binding]; other site
458234004193	putative EF-G interaction site [polypeptide binding]; other site
458234004194	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
458234004195	23S rRNA interface [nucleotide binding]; other site
458234004196	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
458234004197	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
458234004198	mRNA/rRNA interface [nucleotide binding]; other site
458234004199	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
458234004200	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
458234004201	putative thiostrepton binding site; other site
458234004202	23S rRNA interface [nucleotide binding]; other site
458234004203	L7/L12 interface [polypeptide binding]; other site
458234004204	L25 interface [polypeptide binding]; other site
458234004205	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
458234004206	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
458234004207	putative homodimer interface [polypeptide binding]; other site
458234004208	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
458234004209	heterodimer interface [polypeptide binding]; other site
458234004210	homodimer interface [polypeptide binding]; other site
458234004211	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
458234004212	elongation factor Tu; Reviewed; Region: PRK00049
458234004213	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
458234004214	G1 box; other site
458234004215	GEF interaction site [polypeptide binding]; other site
458234004216	GTP/Mg2+ binding site [chemical binding]; other site
458234004217	Switch I region; other site
458234004218	G2 box; other site
458234004219	G3 box; other site
458234004220	Switch II region; other site
458234004221	G4 box; other site
458234004222	G5 box; other site
458234004223	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
458234004224	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
458234004225	Antibiotic Binding Site [chemical binding]; other site
458234004226	AAA domain; Region: AAA_30; pfam13604
458234004227	Family description; Region: UvrD_C_2; pfam13538
458234004228	Mechanosensitive ion channel; Region: MS_channel; pfam00924
458234004229	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
458234004230	amphipathic channel; other site
458234004231	Asn-Pro-Ala signature motifs; other site
458234004232	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
458234004233	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234004234	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234004235	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234004236	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234004237	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
458234004238	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
458234004239	dimer interface [polypeptide binding]; other site
458234004240	phosphorylation site [posttranslational modification]
458234004241	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
458234004242	ATP binding site [chemical binding]; other site
458234004243	Mg2+ binding site [ion binding]; other site
458234004244	G-X-G motif; other site
458234004245	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
458234004246	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
458234004247	NAD(P) binding site [chemical binding]; other site
458234004248	active site
458234004249	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
458234004250	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
458234004251	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
458234004252	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
458234004253	aconitate hydratase; Validated; Region: PRK09277
458234004254	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
458234004255	substrate binding site [chemical binding]; other site
458234004256	ligand binding site [chemical binding]; other site
458234004257	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
458234004258	substrate binding site [chemical binding]; other site
458234004259	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
458234004260	Predicted membrane protein [Function unknown]; Region: COG2246
458234004261	GtrA-like protein; Region: GtrA; pfam04138
458234004262	HemN family oxidoreductase; Provisional; Region: PRK05660
458234004263	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
458234004264	FeS/SAM binding site; other site
458234004265	HemN C-terminal domain; Region: HemN_C; pfam06969
458234004266	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
458234004267	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
458234004268	Preprotein translocase SecG subunit; Region: SecG; pfam03840
458234004269	triosephosphate isomerase; Provisional; Region: PRK14567
458234004270	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
458234004271	substrate binding site [chemical binding]; other site
458234004272	dimer interface [polypeptide binding]; other site
458234004273	catalytic triad [active]
458234004274	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320
458234004275	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
458234004276	active site
458234004277	substrate binding site [chemical binding]; other site
458234004278	metal binding site [ion binding]; metal-binding site
458234004279	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
458234004280	active site
458234004281	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
458234004282	E3 interaction surface; other site
458234004283	lipoyl attachment site [posttranslational modification]; other site
458234004284	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
458234004285	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
458234004286	E3 interaction surface; other site
458234004287	lipoyl attachment site [posttranslational modification]; other site
458234004288	e3 binding domain; Region: E3_binding; pfam02817
458234004289	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
458234004290	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
458234004291	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
458234004292	TPP-binding site [chemical binding]; other site
458234004293	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
458234004294	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
458234004295	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
458234004296	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
458234004297	L-aspartate oxidase; Provisional; Region: PRK06175
458234004298	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
458234004299	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
458234004300	SdhC subunit interface [polypeptide binding]; other site
458234004301	proximal heme binding site [chemical binding]; other site
458234004302	cardiolipin binding site; other site
458234004303	Iron-sulfur protein interface; other site
458234004304	proximal quinone binding site [chemical binding]; other site
458234004305	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
458234004306	Iron-sulfur protein interface; other site
458234004307	proximal quinone binding site [chemical binding]; other site
458234004308	SdhD (CybS) interface [polypeptide binding]; other site
458234004309	proximal heme binding site [chemical binding]; other site
458234004310	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
458234004311	dimer interface [polypeptide binding]; other site
458234004312	Citrate synthase; Region: Citrate_synt; pfam00285
458234004313	active site
458234004314	citrylCoA binding site [chemical binding]; other site
458234004315	NADH binding [chemical binding]; other site
458234004316	cationic pore residues; other site
458234004317	oxalacetate/citrate binding site [chemical binding]; other site
458234004318	coenzyme A binding site [chemical binding]; other site
458234004319	catalytic triad [active]
458234004320	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234004321	muropeptide transporter; Reviewed; Region: ampG; PRK11902
458234004322	putative substrate translocation pore; other site
458234004323	superoxide dismutase; Provisional; Region: PRK10543
458234004324	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
458234004325	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
458234004326	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
458234004327	putative GSH binding site [chemical binding]; other site
458234004328	catalytic residues [active]
458234004329	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
458234004330	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
458234004331	putative active site [active]
458234004332	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452
458234004333	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
458234004334	gamma subunit interface [polypeptide binding]; other site
458234004335	epsilon subunit interface [polypeptide binding]; other site
458234004336	LBP interface [polypeptide binding]; other site
458234004337	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
458234004338	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
458234004339	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
458234004340	alpha subunit interaction interface [polypeptide binding]; other site
458234004341	Walker A motif; other site
458234004342	ATP binding site [chemical binding]; other site
458234004343	Walker B motif; other site
458234004344	inhibitor binding site; inhibition site
458234004345	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
458234004346	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
458234004347	core domain interface [polypeptide binding]; other site
458234004348	delta subunit interface [polypeptide binding]; other site
458234004349	epsilon subunit interface [polypeptide binding]; other site
458234004350	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
458234004351	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
458234004352	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
458234004353	beta subunit interaction interface [polypeptide binding]; other site
458234004354	Walker A motif; other site
458234004355	ATP binding site [chemical binding]; other site
458234004356	Walker B motif; other site
458234004357	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
458234004358	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
458234004359	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
458234004360	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
458234004361	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
458234004362	F0F1 ATP synthase subunit C; Provisional; Region: PRK13464
458234004363	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
458234004364	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
458234004365	Major Facilitator Superfamily; Region: MFS_1; pfam07690
458234004366	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234004367	putative substrate translocation pore; other site
458234004368	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
458234004369	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
458234004370	RNA binding surface [nucleotide binding]; other site
458234004371	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
458234004372	active site
458234004373	Predicted ATPase [General function prediction only]; Region: COG1485
458234004374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234004375	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
458234004376	putative substrate translocation pore; other site
458234004377	histidyl-tRNA synthetase; Region: hisS; TIGR00442
458234004378	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
458234004379	dimer interface [polypeptide binding]; other site
458234004380	motif 1; other site
458234004381	active site
458234004382	motif 2; other site
458234004383	motif 3; other site
458234004384	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
458234004385	anticodon binding site; other site
458234004386	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
458234004387	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
458234004388	translation initiation factor IF-2; Region: IF-2; TIGR00487
458234004389	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
458234004390	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
458234004391	G1 box; other site
458234004392	putative GEF interaction site [polypeptide binding]; other site
458234004393	GTP/Mg2+ binding site [chemical binding]; other site
458234004394	Switch I region; other site
458234004395	G2 box; other site
458234004396	G3 box; other site
458234004397	Switch II region; other site
458234004398	G4 box; other site
458234004399	G5 box; other site
458234004400	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
458234004401	Translation-initiation factor 2; Region: IF-2; pfam11987
458234004402	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
458234004403	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
458234004404	NusA N-terminal domain; Region: NusA_N; pfam08529
458234004405	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
458234004406	RNA binding site [nucleotide binding]; other site
458234004407	homodimer interface [polypeptide binding]; other site
458234004408	NusA-like KH domain; Region: KH_5; pfam13184
458234004409	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
458234004410	G-X-X-G motif; other site
458234004411	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
458234004412	ribosome maturation protein RimP; Reviewed; Region: PRK00092
458234004413	hypothetical protein; Provisional; Region: PRK14641
458234004414	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
458234004415	putative oligomer interface [polypeptide binding]; other site
458234004416	putative RNA binding site [nucleotide binding]; other site
458234004417	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
458234004418	substrate binding site [chemical binding]; other site
458234004419	active site
458234004420	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234004421	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234004422	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234004423	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234004424	Membrane fusogenic activity; Region: BMFP; pfam04380
458234004425	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
458234004426	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
458234004427	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
458234004428	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
458234004429	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
458234004430	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
458234004431	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
458234004432	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
458234004433	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
458234004434	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
458234004435	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
458234004436	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
458234004437	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
458234004438	NADH dehydrogenase subunit G; Validated; Region: PRK09129
458234004439	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
458234004440	catalytic loop [active]
458234004441	iron binding site [ion binding]; other site
458234004442	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
458234004443	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
458234004444	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
458234004445	SLBB domain; Region: SLBB; pfam10531
458234004446	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
458234004447	NADH dehydrogenase subunit E; Validated; Region: PRK07539
458234004448	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
458234004449	putative dimer interface [polypeptide binding]; other site
458234004450	[2Fe-2S] cluster binding site [ion binding]; other site
458234004451	NADH dehydrogenase subunit D; Validated; Region: PRK06075
458234004452	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
458234004453	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
458234004454	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
458234004455	NADH dehydrogenase subunit B; Validated; Region: PRK06411
458234004456	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
458234004457	ferric uptake regulator; Provisional; Region: fur; PRK09462
458234004458	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
458234004459	metal binding site 2 [ion binding]; metal-binding site
458234004460	putative DNA binding helix; other site
458234004461	metal binding site 1 [ion binding]; metal-binding site
458234004462	dimer interface [polypeptide binding]; other site
458234004463	structural Zn2+ binding site [ion binding]; other site
458234004464	IucA / IucC family; Region: IucA_IucC; pfam04183
458234004465	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
458234004466	Major Facilitator Superfamily; Region: MFS_1; pfam07690
458234004467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234004468	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
458234004469	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841
458234004470	dimer interface [polypeptide binding]; other site
458234004471	active site
458234004472	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
458234004473	catalytic residues [active]
458234004474	substrate binding site [chemical binding]; other site
458234004475	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234004476	putative substrate translocation pore; other site
458234004477	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
458234004478	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
458234004479	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
458234004480	GatB domain; Region: GatB_Yqey; smart00845
458234004481	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
458234004482	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
458234004483	Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721
458234004484	adenylosuccinate lyase; Provisional; Region: PRK07492
458234004485	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
458234004486	tetramer interface [polypeptide binding]; other site
458234004487	active site
458234004488	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234004489	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234004490	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234004491	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
458234004492	active site
458234004493	catalytic residues [active]
458234004494	NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521
458234004495	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
458234004496	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
458234004497	dimerization interface [polypeptide binding]; other site
458234004498	ATP binding site [chemical binding]; other site
458234004499	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
458234004500	dimerization interface [polypeptide binding]; other site
458234004501	ATP binding site [chemical binding]; other site
458234004502	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
458234004503	putative active site [active]
458234004504	catalytic triad [active]
458234004505	amidophosphoribosyltransferase; Provisional; Region: PRK09246
458234004506	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
458234004507	active site
458234004508	tetramer interface [polypeptide binding]; other site
458234004509	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
458234004510	active site
458234004511	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
458234004512	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
458234004513	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
458234004514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
458234004515	putative protease; Provisional; Region: PRK15452
458234004516	Peptidase family U32; Region: Peptidase_U32; pfam01136
458234004517	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
458234004518	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234004519	putative substrate translocation pore; other site
458234004520	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
458234004521	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
458234004522	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
458234004523	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
458234004524	GTP1/OBG; Region: GTP1_OBG; pfam01018
458234004525	Obg GTPase; Region: Obg; cd01898
458234004526	G1 box; other site
458234004527	GTP/Mg2+ binding site [chemical binding]; other site
458234004528	Switch I region; other site
458234004529	G2 box; other site
458234004530	G3 box; other site
458234004531	Switch II region; other site
458234004532	G4 box; other site
458234004533	G5 box; other site
458234004534	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
458234004535	aromatic amino acid transport protein; Region: araaP; TIGR00837
458234004536	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
458234004537	DNA binding site [nucleotide binding]
458234004538	K+-transporting ATPase, c chain; Region: KdpC; cl00944
458234004539	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
458234004540	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234004541	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234004542	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234004543	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
458234004544	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234004545	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234004546	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234004547	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234004548	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
458234004549	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
458234004550	substrate binding site [chemical binding]; other site
458234004551	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
458234004552	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
458234004553	substrate binding site [chemical binding]; other site
458234004554	ligand binding site [chemical binding]; other site
458234004555	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234004556	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234004557	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234004558	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234004559	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234004560	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234004561	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
458234004562	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
458234004563	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
458234004564	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
458234004565	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
458234004566	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
458234004567	glutamine synthetase; Region: PLN02284
458234004568	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
458234004569	Eps15 homology domain; Region: EH; smart00027
458234004570	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
458234004571	Glutaminase; Region: Glutaminase; cl00907
458234004572	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
458234004573	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
458234004574	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
458234004575	hypothetical protein; Provisional; Region: PRK05208
458234004576	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
458234004577	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
458234004578	dimer interface [polypeptide binding]; other site
458234004579	putative anticodon binding site; other site
458234004580	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
458234004581	motif 1; other site
458234004582	active site
458234004583	motif 2; other site
458234004584	motif 3; other site
458234004585	This domain is found in peptide chain release factors; Region: PCRF; smart00937
458234004586	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
458234004587	RF-1 domain; Region: RF-1; pfam00472
458234004588	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957
458234004589	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
458234004590	Walker A motif; other site
458234004591	ATP binding site [chemical binding]; other site
458234004592	Walker B motif; other site
458234004593	DNA polymerase III subunit delta'; Validated; Region: PRK08485
458234004594	arginine finger; other site
458234004595	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
458234004596	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
458234004597	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
458234004598	cell division protein FtsZ; Validated; Region: PRK09330
458234004599	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
458234004600	nucleotide binding site [chemical binding]; other site
458234004601	SulA interaction site; other site
458234004602	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
458234004603	Cell division protein FtsA; Region: FtsA; smart00842
458234004604	Cell division protein FtsA; Region: FtsA; pfam14450
458234004605	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
458234004606	Cell division protein FtsQ; Region: FtsQ; pfam03799
458234004607	D-alanyl-alanine synthetase A; Provisional; Region: PRK14569
458234004608	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
458234004609	ATP-grasp domain; Region: ATP-grasp_4; cl17255
458234004610	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
458234004611	nucleoside/Zn binding site; other site
458234004612	dimer interface [polypeptide binding]; other site
458234004613	catalytic motif [active]
458234004614	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
458234004615	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
458234004616	RNA binding site [nucleotide binding]; other site
458234004617	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
458234004618	RNA binding site [nucleotide binding]; other site
458234004619	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
458234004620	RNA binding site [nucleotide binding]; other site
458234004621	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
458234004622	RNA binding site [nucleotide binding]; other site
458234004623	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
458234004624	RNA binding site [nucleotide binding]; other site
458234004625	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
458234004626	RNA binding site [nucleotide binding]; other site
458234004627	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
458234004628	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
458234004629	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
458234004630	putative acyl-acceptor binding pocket; other site
458234004631	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
458234004632	Competence protein; Region: Competence; pfam03772
458234004633	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
458234004634	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
458234004635	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
458234004636	Walker A/P-loop; other site
458234004637	ATP binding site [chemical binding]; other site
458234004638	Q-loop/lid; other site
458234004639	ABC transporter signature motif; other site
458234004640	Walker B; other site
458234004641	D-loop; other site
458234004642	H-loop/switch region; other site
458234004643	YGGT family; Region: YGGT; pfam02325
458234004644	YGGT family; Region: YGGT; pfam02325
458234004645	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231
458234004646	putative active site [active]
458234004647	Zn binding site [ion binding]; other site
458234004648	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234004649	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234004650	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234004651	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234004652	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
458234004653	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
458234004654	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
458234004655	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
458234004656	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
458234004657	purine monophosphate binding site [chemical binding]; other site
458234004658	dimer interface [polypeptide binding]; other site
458234004659	putative catalytic residues [active]
458234004660	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
458234004661	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
458234004662	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
458234004663	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
458234004664	GDP-binding site [chemical binding]; other site
458234004665	ACT binding site; other site
458234004666	IMP binding site; other site
458234004667	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
458234004668	active site
458234004669	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
458234004670	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
458234004671	dimer interface [polypeptide binding]; other site
458234004672	putative PBP binding regions; other site
458234004673	ABC-ATPase subunit  interface; other site
458234004674	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
458234004675	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
458234004676	Walker A/P-loop; other site
458234004677	ATP binding site [chemical binding]; other site
458234004678	Q-loop/lid; other site
458234004679	ABC transporter signature motif; other site
458234004680	Walker B; other site
458234004681	D-loop; other site
458234004682	H-loop/switch region; other site
458234004683	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
458234004684	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
458234004685	intersubunit interface [polypeptide binding]; other site
458234004686	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
458234004687	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
458234004688	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
458234004689	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
458234004690	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
458234004691	primosome assembly protein PriA; Validated; Region: PRK05580
458234004692	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
458234004693	ATP binding site [chemical binding]; other site
458234004694	putative Mg++ binding site [ion binding]; other site
458234004695	helicase superfamily c-terminal domain; Region: HELICc; smart00490
458234004696	Transposase; Region: HTH_Tnp_IS630; pfam01710
458234004697	Helix-turn-helix domain; Region: HTH_28; pfam13518
458234004698	DDE superfamily endonuclease; Region: DDE_3; pfam13358
458234004699	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
458234004700	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
458234004701	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
458234004702	Walker A/P-loop; other site
458234004703	ATP binding site [chemical binding]; other site
458234004704	Q-loop/lid; other site
458234004705	ABC transporter signature motif; other site
458234004706	Walker B; other site
458234004707	D-loop; other site
458234004708	H-loop/switch region; other site
458234004709	ABC transporter; Region: ABC_tran_2; pfam12848
458234004710	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
458234004711	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
458234004712	metabolite-proton symporter; Region: 2A0106; TIGR00883
458234004713	putative substrate translocation pore; other site
458234004714	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
458234004715	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
458234004716	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
458234004717	aminopeptidase N; Provisional; Region: pepN; PRK14015
458234004718	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
458234004719	active site
458234004720	Zn binding site [ion binding]; other site
458234004721	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
458234004722	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
458234004723	putative dimer interface [polypeptide binding]; other site
458234004724	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
458234004725	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
458234004726	active site
458234004727	ribulose/triose binding site [chemical binding]; other site
458234004728	phosphate binding site [ion binding]; other site
458234004729	substrate (anthranilate) binding pocket [chemical binding]; other site
458234004730	product (indole) binding pocket [chemical binding]; other site
458234004731	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
458234004732	active site
458234004733	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
458234004734	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
458234004735	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
458234004736	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
458234004737	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
458234004738	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
458234004739	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
458234004740	Glutamine amidotransferase class-I; Region: GATase; pfam00117
458234004741	glutamine binding [chemical binding]; other site
458234004742	catalytic triad [active]
458234004743	anthranilate synthase component I; Provisional; Region: PRK13564
458234004744	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
458234004745	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
458234004746	Trp repressor protein; Region: Trp_repressor; cl17266
458234004747	ribonuclease G; Provisional; Region: PRK11712
458234004748	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
458234004749	homodimer interface [polypeptide binding]; other site
458234004750	oligonucleotide binding site [chemical binding]; other site