-- dump date 20140619_095325 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_512811.1 89255450 3950877 275..1750 1 NC_007880.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1750 dnaA 3950877 dnaA Francisella tularensis subsp. holarctica LVS chromosomal replication initiation protein YP_512811.1 275 D 376619 CDS YP_512812.1 89255451 3950878 1787..2890 1 NC_007880.1 DNA polymerase III subunit beta 2890 3950878 FTL_0002 Francisella tularensis subsp. holarctica LVS DNA polymerase III subunit beta YP_512812.1 1787 D 376619 CDS YP_512813.1 89255452 3950879 complement(2887..3324) 1 NC_007880.1 hypothetical protein 3324 3950879 FTL_0003 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512813.1 2887 R 376619 CDS YP_512814.1 89255453 3951471 complement(join(3336..3890,3890..4216)) 1 NC_007880.1 transposase 4216 isftu1 3951471 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_512814.1 3336 R 376619 CDS YP_512815.1 89255454 3950880 4306..4944 1 NC_007880.1 Na+/H+ antiporter NHAP, fragment 4944 3950880 FTL_0005 Francisella tularensis subsp. holarctica LVS Na+/H+ antiporter NHAP, fragment YP_512815.1 4306 D 376619 CDS YP_512816.1 89255455 3951372 complement(4954..6354) 1 NC_007880.1 indolepyruvate decarboxylase 6354 3951372 FTL_0006 Francisella tularensis subsp. holarctica LVS indolepyruvate decarboxylase YP_512816.1 4954 R 376619 CDS YP_512817.1 89255456 3951373 complement(6904..7107) 1 NC_007880.1 hypothetical protein 7107 3951373 FTL_0007 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512817.1 6904 R 376619 CDS YP_512818.1 89255457 3951374 7181..8104 1 NC_007880.1 peptidase 8104 3951374 FTL_0008 Francisella tularensis subsp. holarctica LVS peptidase YP_512818.1 7181 D 376619 CDS YP_512819.1 89255458 3951375 8194..8733 1 NC_007880.1 outer membrane protein 8733 3951375 FTL_0009 Francisella tularensis subsp. holarctica LVS outer membrane protein YP_512819.1 8194 D 376619 CDS YP_512820.1 89255459 3951376 8869..9291 1 NC_007880.1 thiosulfate sulfurtransferase 9291 3951376 FTL_0010 Francisella tularensis subsp. holarctica LVS thiosulfate sulfurtransferase YP_512820.1 8869 D 376619 CDS YP_512821.1 89255460 3951377 9318..9767 1 NC_007880.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 9767 3951377 FTL_0011 Francisella tularensis subsp. holarctica LVS preprotein translocase subunit SecB YP_512821.1 9318 D 376619 CDS YP_512822.1 89255461 3951378 9789..10868 1 NC_007880.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 10868 recA 3951378 recA Francisella tularensis subsp. holarctica LVS recombinase A YP_512822.1 9789 D 376619 CDS YP_512823.1 89255462 3951379 10855..11307 1 NC_007880.1 regulatory protein recX 11307 3951379 FTL_0013 Francisella tularensis subsp. holarctica LVS regulatory protein recX YP_512823.1 10855 D 376619 CDS YP_512824.1 89255463 3951380 11480..11956 1 NC_007880.1 single-strand binding protein 11956 3951380 FTL_0014 Francisella tularensis subsp. holarctica LVS single-strand binding protein YP_512824.1 11480 D 376619 CDS YP_512825.1 89255464 3951381 12062..13216 1 NC_007880.1 propionate kinase 13216 3951381 FTL_0015 Francisella tularensis subsp. holarctica LVS propionate kinase YP_512825.1 12062 D 376619 CDS YP_512826.1 89255465 3951382 13226..15322 1 NC_007880.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 15322 3951382 FTL_0016 Francisella tularensis subsp. holarctica LVS phosphate acetyltransferase YP_512826.1 13226 D 376619 CDS YP_512827.1 89255466 3951472 complement(join(16234..16788,16788..17114)) 1 NC_007880.1 transposase 17114 isftu1 3951472 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_512827.1 16234 R 376619 CDS YP_512828.1 89255467 3951384 complement(17176..17472) 1 NC_007880.1 sugar transferase 17472 3951384 FTL_0019 Francisella tularensis subsp. holarctica LVS sugar transferase YP_512828.1 17176 R 376619 CDS YP_512829.1 89255468 3951385 complement(17609..19381) 1 NC_007880.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 19381 aspS 3951385 aspS Francisella tularensis subsp. holarctica LVS aspartyl-tRNA synthetase YP_512829.1 17609 R 376619 CDS YP_512830.1 89255469 3951386 complement(19555..20736) 1 NC_007880.1 MFS superfamily proline/ betaine transporter 20736 3951386 FTL_0021 Francisella tularensis subsp. holarctica LVS MFS superfamily proline/ betaine transporter YP_512830.1 19555 R 376619 CDS YP_512831.1 89255470 3951473 join(21378..21704,21704..22258) 1 NC_007880.1 transposase 22258 isftu1 3951473 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_512831.1 21378 D 376619 CDS YP_512832.1 89255471 3951388 complement(23205..24428) 1 NC_007880.1 serine transporter 24428 3951388 FTL_0024 Francisella tularensis subsp. holarctica LVS serine transporter YP_512832.1 23205 R 376619 CDS YP_512833.1 89255472 3951389 complement(24755..24988) 1 NC_007880.1 hypothetical protein 24988 3951389 FTL_0025 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512833.1 24755 R 376619 CDS YP_512834.1 89255473 3951390 25480..25788 1 NC_007880.1 3-hydroxyisobutyrate dehydrogenase 25788 3951390 FTL_0026 Francisella tularensis subsp. holarctica LVS 3-hydroxyisobutyrate dehydrogenase YP_512834.1 25480 D 376619 CDS YP_512835.1 89255474 3952623 25840..26358 1 NC_007880.1 3-hydroxyisobutyrate dehydrogenase 26358 3952623 FTL_0027 Francisella tularensis subsp. holarctica LVS 3-hydroxyisobutyrate dehydrogenase YP_512835.1 25840 D 376619 CDS YP_512836.1 89255475 3952624 complement(26372..27292) 1 NC_007880.1 aspartate carbamoyltransferase 27292 3952624 FTL_0028 Francisella tularensis subsp. holarctica LVS aspartate carbamoyltransferase YP_512836.1 26372 R 376619 CDS YP_512837.1 89255476 3952625 complement(27434..30718) 1 NC_007880.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 30718 carB 3952625 carB Francisella tularensis subsp. holarctica LVS carbamoyl phosphate synthase large subunit YP_512837.1 27434 R 376619 CDS YP_512838.1 89255477 3952626 complement(30723..31889) 1 NC_007880.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 31889 3952626 FTL_0030 Francisella tularensis subsp. holarctica LVS carbamoyl phosphate synthase small subunit YP_512838.1 30723 R 376619 CDS YP_512839.1 89255478 3952627 32306..33361 1 NC_007880.1 acid phosphatase 33361 3952627 FTL_0031 Francisella tularensis subsp. holarctica LVS acid phosphatase YP_512839.1 32306 D 376619 CDS YP_512840.1 89255479 3952628 complement(33485..34165) 1 NC_007880.1 catalyzes the S-adenosylmethionine-dependent transmethylation of thiopurine compounds; may be involved in selenium cycling by forming dimethylselenide and/or dimethyldiselenide; thiopurine S-methyltransferase 34165 3952628 FTL_0032 Francisella tularensis subsp. holarctica LVS thiopurine S-methyltransferase YP_512840.1 33485 R 376619 CDS YP_512841.1 89255480 3952629 34297..35643 1 NC_007880.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; dihydroorotase 35643 3952629 FTL_0033 Francisella tularensis subsp. holarctica LVS dihydroorotase YP_512841.1 34297 D 376619 CDS YP_512842.1 89255481 3952630 complement(35671..36711) 1 NC_007880.1 hypothetical protein 36711 3952630 FTL_0034 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512842.1 35671 R 376619 CDS YP_512843.1 89255482 3952631 37248..37526 1 NC_007880.1 hypothetical protein 37526 3952631 FTL_0035 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512843.1 37248 D 376619 CDS YP_512844.1 89255483 3952632 37915..38466 1 NC_007880.1 hypothetical protein 38466 3952632 FTL_0036 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512844.1 37915 D 376619 CDS YP_512845.1 89255484 3952633 complement(38582..39634) 1 NC_007880.1 hypothetical protein 39634 3952633 FTL_0037 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512845.1 38582 R 376619 CDS YP_512846.1 89255485 3952634 complement(39621..40586) 1 NC_007880.1 HlyD family secretion protein 40586 3952634 FTL_0038 Francisella tularensis subsp. holarctica LVS HlyD family secretion protein YP_512846.1 39621 R 376619 CDS YP_512847.1 89255486 3952635 complement(40675..41082) 1 NC_007880.1 hypothetical protein 41082 3952635 FTL_0039 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512847.1 40675 R 376619 CDS YP_512848.1 89255487 3952636 41208..42077 1 NC_007880.1 LysR family transcriptional regulator 42077 3952636 FTL_0040 Francisella tularensis subsp. holarctica LVS LysR family transcriptional regulator YP_512848.1 41208 D 376619 CDS YP_512849.1 89255488 3952637 complement(42078..42449) 1 NC_007880.1 hypothetical protein 42449 3952637 FTL_0041 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512849.1 42078 R 376619 CDS YP_512850.1 89255489 3951803 complement(42739..43365) 1 NC_007880.1 transposase 43365 isftu2 3951803 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_512850.1 42739 R 376619 CDS YP_512851.1 89255490 3952638 43704..44252 1 NC_007880.1 chorismate mutase 44252 3952638 FTL_0043 Francisella tularensis subsp. holarctica LVS chorismate mutase YP_512851.1 43704 D 376619 CDS YP_512852.1 89255491 3952639 complement(44307..47540) 1 NC_007880.1 transglutaminase 47540 3952639 FTL_0044 Francisella tularensis subsp. holarctica LVS transglutaminase YP_512852.1 44307 R 376619 CDS YP_512853.1 89255492 3952640 47960..48592 1 NC_007880.1 orotidine 5'-phosphate decarboxylase 48592 3952640 FTL_0045 Francisella tularensis subsp. holarctica LVS orotidine 5'-phosphate decarboxylase YP_512853.1 47960 D 376619 CDS YP_512854.1 89255493 3952641 48594..49340 1 NC_007880.1 diyroorotate dehydrogenase 49340 3952641 FTL_0046 Francisella tularensis subsp. holarctica LVS diyroorotate dehydrogenase YP_512854.1 48594 D 376619 CDS YP_512855.1 89255494 3952642 complement(49699..49869) 1 NC_007880.1 hypothetical protein 49869 3952642 FTL_0047 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512855.1 49699 R 376619 CDS YP_512856.1 89255495 3951020 complement(49873..50535) 1 NC_007880.1 prephenate dehydrogenase. 50535 3951020 FTL_0048 Francisella tularensis subsp. holarctica LVS prephenate dehydrogenase. YP_512856.1 49873 R 376619 CDS YP_512857.1 89255496 3951021 complement(50803..51240) 1 NC_007880.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 51240 3951021 FTL_0049 Francisella tularensis subsp. holarctica LVS D-tyrosyl-tRNA(Tyr) deacylase YP_512857.1 50803 R 376619 CDS YP_512858.1 89255497 3951022 complement(51483..52169) 1 NC_007880.1 hypothetical protein 52169 3951022 FTL_0050 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512858.1 51483 R 376619 CDS YP_512859.1 89255498 3951023 complement(52317..52715) 1 NC_007880.1 hypothetical protein 52715 3951023 FTL_0051 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512859.1 52317 R 376619 CDS YP_512860.1 89255499 3951024 complement(52734..53273) 1 NC_007880.1 hypothetical protein 53273 3951024 FTL_0052 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512860.1 52734 R 376619 CDS YP_512861.1 89255500 3951025 complement(53270..54202) 1 NC_007880.1 Beta-fructofuranosidase 54202 3951025 FTL_0053 Francisella tularensis subsp. holarctica LVS Beta-fructofuranosidase YP_512861.1 53270 R 376619 CDS YP_512862.1 89255501 3951474 complement(join(54408..54962,54962..55288)) 1 NC_007880.1 transposase 55288 isftu1 3951474 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_512862.1 54408 R 376619 CDS YP_512863.1 89255502 3951026 complement(55312..55863) 1 NC_007880.1 hypothetical protein 55863 3951026 FTL_0055 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512863.1 55312 R 376619 CDS YP_512864.1 89255503 3951027 complement(56134..56799) 1 NC_007880.1 NADH dehydrogenase 56799 3951027 FTL_0056 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase YP_512864.1 56134 R 376619 CDS YP_512865.1 89255504 3951028 57202..57894 1 NC_007880.1 hypothetical protein 57894 3951028 FTL_0057 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512865.1 57202 D 376619 CDS YP_512866.1 89255505 3951029 complement(57891..59096) 1 NC_007880.1 aromatic amino acid HAAP transporter 59096 3951029 FTL_0058 Francisella tularensis subsp. holarctica LVS aromatic amino acid HAAP transporter YP_512866.1 57891 R 376619 CDS YP_512867.1 89255506 3951030 59196..59813 1 NC_007880.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 59813 gidB 3951030 gidB Francisella tularensis subsp. holarctica LVS 16S rRNA methyltransferase GidB YP_512867.1 59196 D 376619 CDS YP_512868.1 89255507 3951031 59810..60478 1 NC_007880.1 hypothetical protein 60478 3951031 FTL_0060 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512868.1 59810 D 376619 CDS YP_512869.1 89255508 3951032 complement(60471..61355) 1 NC_007880.1 hypothetical protein 61355 3951032 FTL_0061 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512869.1 60471 R 376619 CDS YP_512870.1 89255509 3951033 complement(61557..62048) 1 NC_007880.1 transcriptional regulator 62048 3951033 FTL_0062 Francisella tularensis subsp. holarctica LVS transcriptional regulator YP_512870.1 61557 R 376619 CDS YP_512871.1 89255510 3951034 62556..63692 1 NC_007880.1 major facilitator transporter 63692 3951034 FTL_0063 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_512871.1 62556 D 376619 CDS YP_512872.1 89255511 3952643 66214..66810 1 NC_007880.1 phosphoheptose isomerase 66810 3952643 FTL_0068 Francisella tularensis subsp. holarctica LVS phosphoheptose isomerase YP_512872.1 66214 D 376619 CDS YP_512873.1 89255512 3952644 66818..67174 1 NC_007880.1 outer membrane lipoprotein 67174 3952644 FTL_0069 Francisella tularensis subsp. holarctica LVS outer membrane lipoprotein YP_512873.1 66818 D 376619 CDS YP_512874.1 89255513 3952645 complement(67248..67520) 1 NC_007880.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 67520 rpsT 3952645 rpsT Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S20 YP_512874.1 67248 R 376619 CDS YP_512875.1 89255514 3952646 67790..69574 1 NC_007880.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 69574 3952646 FTL_0071 Francisella tularensis subsp. holarctica LVS GTP-binding protein LepA YP_512875.1 67790 D 376619 CDS YP_512876.1 89255515 3952647 69588..70667 1 NC_007880.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 70667 mnmA 3952647 mnmA Francisella tularensis subsp. holarctica LVS tRNA-specific 2-thiouridylase MnmA YP_512876.1 69588 D 376619 CDS YP_512877.1 89255516 3952648 complement(70687..71679) 1 NC_007880.1 hypothetical protein 71679 3952648 FTL_0073 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512877.1 70687 R 376619 CDS YP_512878.1 89255517 3952649 complement(71761..72279) 1 NC_007880.1 peptide deformylase 72279 3952649 FTL_0074 Francisella tularensis subsp. holarctica LVS peptide deformylase YP_512878.1 71761 R 376619 CDS YP_512879.1 89255518 3952650 complement(72282..72725) 1 NC_007880.1 riboflavin synthase beta subunit (6,7-dimethl-8-ribityllumazine synthase) 72725 3952650 FTL_0075 Francisella tularensis subsp. holarctica LVS riboflavin synthase beta subunit (6,7-dimethl-8-ribityllumazine synthase) YP_512879.1 72282 R 376619 CDS YP_512880.1 89255519 3952651 complement(72735..73946) 1 NC_007880.1 riboflavin biosynthesis protein ribA/GTP-cyclohydrolase II 73946 3952651 FTL_0076 Francisella tularensis subsp. holarctica LVS riboflavin biosynthesis protein ribA/GTP-cyclohydrolase II YP_512880.1 72735 R 376619 CDS YP_512881.1 89255520 3952652 complement(73939..74544) 1 NC_007880.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 74544 3952652 FTL_0077 Francisella tularensis subsp. holarctica LVS riboflavin synthase subunit alpha YP_512881.1 73939 R 376619 CDS YP_512882.1 89255521 3952653 complement(74537..75604) 1 NC_007880.1 riboflavin biosynthesis protein ribD 75604 3952653 FTL_0078 Francisella tularensis subsp. holarctica LVS riboflavin biosynthesis protein ribD YP_512882.1 74537 R 376619 CDS YP_512883.1 89255522 3951804 complement(75931..76557) 1 NC_007880.1 transposase 76557 isftu2 3951804 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_512883.1 75931 R 376619 CDS YP_512884.1 89255523 3951475 complement(join(76775..77278,77278..77604)) 1 NC_007880.1 transposase 77604 isftu1 3951475 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_512884.1 76775 R 376619 CDS YP_512885.1 89255524 3952655 complement(78577..79092) 1 NC_007880.1 B-type cytochrome 79092 3952655 FTL_0082 Francisella tularensis subsp. holarctica LVS B-type cytochrome YP_512885.1 78577 R 376619 CDS YP_512886.1 89255525 3952658 80142..81293 1 NC_007880.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 81293 nhaA 3952658 nhaA Francisella tularensis subsp. holarctica LVS pH-dependent sodium/proton antiporter YP_512886.1 80142 D 376619 CDS YP_512887.1 89255526 3952659 81358..82077 1 NC_007880.1 hypothetical protein 82077 3952659 FTL_0086 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512887.1 81358 D 376619 CDS YP_512888.1 89255527 3952660 complement(82083..82823) 1 NC_007880.1 acetyltransferase protein 82823 3952660 FTL_0087 Francisella tularensis subsp. holarctica LVS acetyltransferase protein YP_512888.1 82083 R 376619 CDS YP_512889.1 89255528 3952661 complement(82837..83589) 1 NC_007880.1 acetyltransferase protein 83589 3952661 FTL_0088 Francisella tularensis subsp. holarctica LVS acetyltransferase protein YP_512889.1 82837 R 376619 CDS YP_512890.1 89255529 3952662 complement(83752..84075) 1 NC_007880.1 ferredoxin 84075 3952662 FTL_0089 Francisella tularensis subsp. holarctica LVS ferredoxin YP_512890.1 83752 R 376619 CDS YP_512891.1 89255530 3952267 84308..84949 1 NC_007880.1 hypothetical protein 84949 3952267 FTL_0090 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512891.1 84308 D 376619 CDS YP_512892.1 89255531 3952268 85149..85565 1 NC_007880.1 O-methyltransferase 85565 3952268 FTL_0091 Francisella tularensis subsp. holarctica LVS O-methyltransferase YP_512892.1 85149 D 376619 CDS YP_512893.1 89255532 3952269 complement(85682..86842) 1 NC_007880.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 86842 purT 3952269 purT Francisella tularensis subsp. holarctica LVS phosphoribosylglycinamide formyltransferase 2 YP_512893.1 85682 R 376619 CDS YP_512894.1 89255533 3952270 complement(86896..89088) 1 NC_007880.1 chitinase 89088 3952270 FTL_0093 Francisella tularensis subsp. holarctica LVS chitinase YP_512894.1 86896 R 376619 CDS YP_512895.1 89255534 3952271 complement(89339..91918) 1 NC_007880.1 ClpB protein 91918 3952271 FTL_0094 Francisella tularensis subsp. holarctica LVS ClpB protein YP_512895.1 89339 R 376619 CDS YP_512896.1 89255535 3952274 92864..93217 1 NC_007880.1 hypothetical protein 93217 3952274 FTL_0097 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512896.1 92864 D 376619 CDS YP_512897.1 89255536 3952275 complement(93272..94081) 1 NC_007880.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 94081 trpA 3952275 trpA Francisella tularensis subsp. holarctica LVS tryptophan synthase subunit alpha YP_512897.1 93272 R 376619 CDS YP_512898.1 89255537 3952276 complement(94081..95271) 1 NC_007880.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 95271 3952276 FTL_0099 Francisella tularensis subsp. holarctica LVS tryptophan synthase subunit beta YP_512898.1 94081 R 376619 CDS YP_512899.1 89255538 3952277 complement(95358..96863) 1 NC_007880.1 carboxypeptidase,fragment 96863 3952277 FTL_0100 Francisella tularensis subsp. holarctica LVS carboxypeptidase,fragment YP_512899.1 95358 R 376619 CDS YP_512900.1 89255539 3952278 complement(96799..97863) 1 NC_007880.1 voltage-gated ClC-type chloride channel clcA 97863 3952278 FTL_0101 Francisella tularensis subsp. holarctica LVS voltage-gated ClC-type chloride channel clcA YP_512900.1 96799 R 376619 CDS YP_512901.1 89255540 3952279 complement(97893..98216) 1 NC_007880.1 hypothetical protein 98216 3952279 FTL_0102 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512901.1 97893 R 376619 CDS YP_512902.1 89255541 3952280 complement(98400..98684) 1 NC_007880.1 hypothetical protein 98684 3952280 FTL_0103 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512902.1 98400 R 376619 CDS YP_512903.1 89255542 3952281 complement(98687..99097) 1 NC_007880.1 hypothetical protein 99097 3952281 FTL_0104 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512903.1 98687 R 376619 CDS YP_512904.1 89255543 3952282 complement(99118..99510) 1 NC_007880.1 hypothetical protein 99510 3952282 FTL_0105 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512904.1 99118 R 376619 CDS YP_512905.1 89255544 3951476 join(100311..100635,100635..101191) 1 NC_007880.1 transposase 101191 isftu1 3951476 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_512905.1 100311 D 376619 CDS YP_512906.1 89255545 3952284 complement(101192..102064) 1 NC_007880.1 hypothetical protein 102064 3952284 FTL_0108 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512906.1 101192 R 376619 CDS YP_512907.1 89255546 3952285 102157..102558 1 NC_007880.1 hypothetical protein 102558 3952285 FTL_0109 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512907.1 102157 D 376619 CDS YP_512908.1 89255547 3951720 102568..102771 1 NC_007880.1 hypothetical protein 102771 3951720 FTL_0110 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512908.1 102568 D 376619 CDS YP_512909.1 89255548 3951721 102852..103406 1 NC_007880.1 intracellular growth locus, subunit A 103406 3951721 FTL_0111 Francisella tularensis subsp. holarctica LVS intracellular growth locus, subunit A YP_512909.1 102852 D 376619 CDS YP_512910.1 89255549 3951722 103420..104940 1 NC_007880.1 intracellular growth locus, subunit B 104940 3951722 FTL_0112 Francisella tularensis subsp. holarctica LVS intracellular growth locus, subunit B YP_512910.1 103420 D 376619 CDS YP_512911.1 89255550 3951723 104957..105586 1 NC_007880.1 intracellular growth locus, subunit C 105586 3951723 FTL_0113 Francisella tularensis subsp. holarctica LVS intracellular growth locus, subunit C YP_512911.1 104957 D 376619 CDS YP_512912.1 89255551 3951724 105607..106803 1 NC_007880.1 intracellular growth locus, subunit D 106803 3951724 FTL_0114 Francisella tularensis subsp. holarctica LVS intracellular growth locus, subunit D YP_512912.1 105607 D 376619 CDS YP_512913.1 89255552 3951725 complement(106810..107385) 1 NC_007880.1 hypothetical protein 107385 3951725 FTL_0115 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512913.1 106810 R 376619 CDS YP_512914.1 89255553 3951726 complement(107403..111389) 1 NC_007880.1 hypothetical protein 111389 3951726 FTL_0116 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512914.1 107403 R 376619 CDS YP_512915.1 89255554 3951727 complement(111429..112202) 1 NC_007880.1 hypothetical protein 112202 3951727 FTL_0117 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512915.1 111429 R 376619 CDS YP_512916.1 89255555 3951728 complement(112168..113319) 1 NC_007880.1 hypothetical protein 113319 3951728 FTL_0118 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512916.1 112168 R 376619 CDS YP_512917.1 89255556 3951729 complement(113341..113964) 1 NC_007880.1 hypothetical protein 113964 3951729 FTL_0119 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512917.1 113341 R 376619 CDS YP_512918.1 89255557 3951730 complement(113977..115407) 1 NC_007880.1 hypothetical protein 115407 3951730 FTL_0120 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512918.1 113977 R 376619 CDS YP_512919.1 89255558 3951731 complement(115420..115941) 1 NC_007880.1 hypothetical protein 115941 3951731 FTL_0121 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512919.1 115420 R 376619 CDS YP_512920.1 89255559 3951732 complement(116009..117673) 1 NC_007880.1 hypothetical protein 117673 3951732 FTL_0122 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512920.1 116009 R 376619 CDS YP_512921.1 89255560 3951733 complement(117678..118172) 1 NC_007880.1 hypothetical protein 118172 3951733 FTL_0123 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512921.1 117678 R 376619 CDS YP_512922.1 89255561 3951734 complement(118185..118562) 1 NC_007880.1 hypothetical protein 118562 3951734 FTL_0124 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512922.1 118185 R 376619 CDS YP_512923.1 89255562 3951735 complement(118552..121833) 1 NC_007880.1 hypothetical protein 121833 3951735 FTL_0125 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512923.1 118552 R 376619 CDS YP_512924.1 89255563 3951736 complement(121838..124300) 1 NC_007880.1 hypothetical protein 124300 3951736 FTL_0126 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512924.1 121838 R 376619 CDS YP_512925.1 89255564 3951737 129871..130587 1 NC_007880.1 formate dehydrogenase 130587 3951737 FTL_0127 Francisella tularensis subsp. holarctica LVS formate dehydrogenase YP_512925.1 129871 D 376619 CDS YP_512926.1 89255565 3951477 join(130645..130969,130969..131525) 1 NC_007880.1 transposase 131525 isftu1 3951477 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_512926.1 130645 D 376619 CDS YP_512927.1 89255566 3951738 complement(131814..132632) 1 NC_007880.1 2-isopropylmalate synthase 132632 3951738 FTL_0129 Francisella tularensis subsp. holarctica LVS 2-isopropylmalate synthase YP_512927.1 131814 R 376619 CDS YP_512928.1 89255567 3951739 complement(132640..132894) 1 NC_007880.1 isopropylmalate/homocitrate/citramalate synthase family protein 132894 3951739 FTL_0130 Francisella tularensis subsp. holarctica LVS isopropylmalate/homocitrate/citramalate synthase family protein YP_512928.1 132640 R 376619 CDS YP_512929.1 89255568 3951740 complement(132905..133792) 1 NC_007880.1 branched-chain amino acid aminotransferase 133792 3951740 FTL_0131 Francisella tularensis subsp. holarctica LVS branched-chain amino acid aminotransferase YP_512929.1 132905 R 376619 CDS YP_512930.1 89255569 3951741 complement(134193..136826) 1 NC_007880.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 136826 3951741 FTL_0132 Francisella tularensis subsp. holarctica LVS pyruvate phosphate dikinase YP_512930.1 134193 R 376619 CDS YP_512931.1 89255570 3951742 complement(137653..139896) 1 NC_007880.1 ferrous iron transport protein 139896 3951742 FTL_0133 Francisella tularensis subsp. holarctica LVS ferrous iron transport protein YP_512931.1 137653 R 376619 CDS YP_512932.1 89255571 3951743 complement(139997..140470) 1 NC_007880.1 hypothetical protein 140470 3951743 FTL_0134 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512932.1 139997 R 376619 CDS YP_512933.1 89255572 3951478 complement(join(140442..140996,140996..141322)) 1 NC_007880.1 transposase 141322 isftu1 3951478 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_512933.1 140442 R 376619 CDS YP_512934.1 89255573 3951744 complement(141811..142443) 1 NC_007880.1 hypothetical protein 142443 3951744 FTL_0136 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512934.1 141811 R 376619 CDS YP_512935.1 89255574 3951745 complement(143094..144062) 1 NC_007880.1 lipopolysaccharide protein 144062 3951745 FTL_0137 Francisella tularensis subsp. holarctica LVS lipopolysaccharide protein YP_512935.1 143094 R 376619 CDS YP_512936.1 89255575 3951746 144251..146101 1 NC_007880.1 ribonuclease II family protein 146101 3951746 FTL_0138 Francisella tularensis subsp. holarctica LVS ribonuclease II family protein YP_512936.1 144251 D 376619 CDS YP_512937.1 89255576 3951747 146438..147106 1 NC_007880.1 carboxylesterase/phospholipase family protein 147106 3951747 FTL_0139 Francisella tularensis subsp. holarctica LVS carboxylesterase/phospholipase family protein YP_512937.1 146438 D 376619 CDS YP_512938.1 89255577 3951748 147103..148005 1 NC_007880.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 148005 hemC 3951748 hemC Francisella tularensis subsp. holarctica LVS porphobilinogen deaminase YP_512938.1 147103 D 376619 CDS YP_512939.1 89255578 3951749 148006..148341 1 NC_007880.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 148341 3951749 FTL_0141 Francisella tularensis subsp. holarctica LVS camphor resistance protein CrcB YP_512939.1 148006 D 376619 CDS YP_512940.1 89255579 3951750 148394..148801 1 NC_007880.1 hypothetical protein 148801 3951750 FTL_0142 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512940.1 148394 D 376619 CDS YP_512941.1 89255580 3951751 149154..149531 1 NC_007880.1 hypothetical protein 149531 3951751 FTL_0143 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512941.1 149154 D 376619 CDS YP_512942.1 89255581 3951752 complement(149528..149701) 1 NC_007880.1 hypothetical protein 149701 3951752 FTL_0144 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512942.1 149528 R 376619 CDS YP_512943.1 89255582 3951753 149830..151629 1 NC_007880.1 ABC transporter membrane protein 151629 3951753 FTL_0145 Francisella tularensis subsp. holarctica LVS ABC transporter membrane protein YP_512943.1 149830 D 376619 CDS YP_512944.1 89255583 3951754 151648..152964 1 NC_007880.1 ABC transporter ATP-binding protein 152964 3951754 FTL_0146 Francisella tularensis subsp. holarctica LVS ABC transporter ATP-binding protein YP_512944.1 151648 D 376619 CDS YP_512945.1 89255584 3951755 153051..154589 1 NC_007880.1 hypothetical protein 154589 3951755 FTL_0147 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512945.1 153051 D 376619 CDS YP_512946.1 89255585 3951756 154695..156569 1 NC_007880.1 Sodium/hydrogen exchanger (antiporter) family protein 156569 3951756 FTL_0148 Francisella tularensis subsp. holarctica LVS Sodium/hydrogen exchanger (antiporter) family protein YP_512946.1 154695 D 376619 CDS YP_512947.1 89255586 3951757 156554..157093 1 NC_007880.1 carbonic anhydrase 157093 3951757 FTL_0149 Francisella tularensis subsp. holarctica LVS carbonic anhydrase YP_512947.1 156554 D 376619 CDS YP_512948.1 89255587 3951758 157020..157688 1 NC_007880.1 lipoprotein releasing system, subunit B, outer membrane lipoprotein 157688 3951758 FTL_0150 Francisella tularensis subsp. holarctica LVS lipoprotein releasing system, subunit B, outer membrane lipoprotein YP_512948.1 157020 D 376619 CDS YP_512949.1 89255588 3951779 157676..158503 1 NC_007880.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 158503 ipk 3951779 ipk Francisella tularensis subsp. holarctica LVS 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_512949.1 157676 D 376619 CDS YP_512950.1 89255589 3951780 158692..159012 1 NC_007880.1 hypothetical protein 159012 3951780 FTL_0152 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512950.1 158692 D 376619 CDS YP_512951.1 89255590 3951479 join(159036..159362,159362..159916) 1 NC_007880.1 transposase 159916 isftu1 3951479 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_512951.1 159036 D 376619 CDS YP_512952.1 89255591 3951783 complement(160758..161753) 1 NC_007880.1 phosphate transport protein 161753 3951783 FTL_0156 Francisella tularensis subsp. holarctica LVS phosphate transport protein YP_512952.1 160758 R 376619 CDS YP_512953.1 89255592 3951784 complement(161771..162427) 1 NC_007880.1 hypothetical protein 162427 3951784 FTL_0157 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512953.1 161771 R 376619 CDS YP_512954.1 89255593 3951785 162734..164209 1 NC_007880.1 acid phosphatase 164209 3951785 FTL_0158 Francisella tularensis subsp. holarctica LVS acid phosphatase YP_512954.1 162734 D 376619 CDS YP_512955.1 89255594 3951786 complement(164216..165028) 1 NC_007880.1 hydrolase subunit 165028 3951786 FTL_0159 Francisella tularensis subsp. holarctica LVS hydrolase subunit YP_512955.1 164216 R 376619 CDS YP_512956.1 89255595 3951787 complement(165112..165729) 1 NC_007880.1 LamB/YcsF family protein 165729 3951787 FTL_0160 Francisella tularensis subsp. holarctica LVS LamB/YcsF family protein YP_512956.1 165112 R 376619 CDS YP_512957.1 89255596 3951789 complement(166392..167090) 1 NC_007880.1 hypothetical protein 167090 3951789 FTL_0162 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512957.1 166392 R 376619 CDS YP_512958.1 89255597 3951790 complement(167216..167356) 1 NC_007880.1 MFS transporter 167356 3951790 FTL_0163 Francisella tularensis subsp. holarctica LVS MFS transporter YP_512958.1 167216 R 376619 CDS YP_512959.1 89255598 3951480 complement(join(167422..167976,167976..168302)) 1 NC_007880.1 transposase 168302 isftu1 3951480 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_512959.1 167422 R 376619 CDS YP_512960.1 89255599 3951791 complement(168385..168546) 1 NC_007880.1 dicarboxylate MFS transporter 168546 3951791 FTL_0165 Francisella tularensis subsp. holarctica LVS dicarboxylate MFS transporter YP_512960.1 168385 R 376619 CDS YP_512961.1 89255600 3951792 complement(168662..169498) 1 NC_007880.1 universal stress protein 169498 3951792 FTL_0166 Francisella tularensis subsp. holarctica LVS universal stress protein YP_512961.1 168662 R 376619 CDS YP_512962.1 89255601 3951793 complement(169574..172315) 1 NC_007880.1 DNA/RNA helicase 172315 3951793 FTL_0167 Francisella tularensis subsp. holarctica LVS DNA/RNA helicase YP_512962.1 169574 R 376619 CDS YP_512963.1 89255602 3951794 complement(172299..173051) 1 NC_007880.1 hypothetical protein 173051 3951794 FTL_0168 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512963.1 172299 R 376619 CDS YP_512964.1 89255603 3951795 complement(173151..173714) 1 NC_007880.1 hypothetical protein 173714 3951795 FTL_0169 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512964.1 173151 R 376619 CDS YP_512965.1 89255604 3951796 174113..174526 1 NC_007880.1 hypothetical protein 174526 3951796 FTL_0170 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512965.1 174113 D 376619 CDS YP_512966.1 89255605 3951797 complement(174537..175409) 1 NC_007880.1 tetrapyrrole methyltransferase family protein 175409 3951797 FTL_0171 Francisella tularensis subsp. holarctica LVS tetrapyrrole methyltransferase family protein YP_512966.1 174537 R 376619 CDS YP_512967.1 89255606 3951798 complement(175402..176757) 1 NC_007880.1 UDP-N-acetylmuramate--L-alanine ligase 176757 3951798 FTL_0172 Francisella tularensis subsp. holarctica LVS UDP-N-acetylmuramate--L-alanine ligase YP_512967.1 175402 R 376619 CDS YP_512968.1 89255607 3951839 complement(176824..177597) 1 NC_007880.1 shikimate 5-dehydrogenase 177597 3951839 FTL_0173 Francisella tularensis subsp. holarctica LVS shikimate 5-dehydrogenase YP_512968.1 176824 R 376619 CDS YP_512969.1 89255608 3951840 177724..178182 1 NC_007880.1 hypothetical protein 178182 3951840 FTL_0174 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512969.1 177724 D 376619 CDS YP_512970.1 89255609 3951841 178274..178408 1 NC_007880.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 178408 rpmH 3951841 rpmH Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L34 YP_512970.1 178274 D 376619 CDS YP_512971.1 89255610 3951842 178398..178751 1 NC_007880.1 ribonuclease P protein component 178751 3951842 FTL_0176 Francisella tularensis subsp. holarctica LVS ribonuclease P protein component YP_512971.1 178398 D 376619 CDS YP_512972.1 89255611 3951843 178727..178975 1 NC_007880.1 hypothetical protein 178975 3951843 FTL_0177 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512972.1 178727 D 376619 CDS YP_512973.1 89255612 3951844 178984..180639 1 NC_007880.1 inner-membrane protein 180639 3951844 FTL_0178 Francisella tularensis subsp. holarctica LVS inner-membrane protein YP_512973.1 178984 D 376619 CDS YP_512974.1 89255613 3951845 180646..181545 1 NC_007880.1 acyltransferase 181545 3951845 FTL_0179 Francisella tularensis subsp. holarctica LVS acyltransferase YP_512974.1 180646 D 376619 CDS YP_512975.1 89255614 3951846 181606..182529 1 NC_007880.1 acyltransferase 182529 3951846 FTL_0180 Francisella tularensis subsp. holarctica LVS acyltransferase YP_512975.1 181606 D 376619 CDS YP_512976.1 89255615 3951847 182542..182949 1 NC_007880.1 Type IV pili fiber building block protein 182949 3951847 FTL_0181 Francisella tularensis subsp. holarctica LVS Type IV pili fiber building block protein YP_512976.1 182542 D 376619 CDS YP_512977.1 89255616 3951848 182989..183558 1 NC_007880.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 183558 3951848 FTL_0182 Francisella tularensis subsp. holarctica LVS elongation factor P YP_512977.1 182989 D 376619 CDS YP_512978.1 89255617 3951849 183561..184097 1 NC_007880.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 184097 3951849 FTL_0183 Francisella tularensis subsp. holarctica LVS oligoribonuclease YP_512978.1 183561 D 376619 CDS YP_512979.1 89255618 3951850 184132..184326 1 NC_007880.1 hypothetical protein 184326 3951850 FTL_0184 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512979.1 184132 D 376619 CDS YP_512980.1 89255619 3951481 join(184350..184674,184674..185230) 1 NC_007880.1 transposase 185230 isftu1 3951481 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_512980.1 184350 D 376619 CDS YP_512981.1 89255620 3951851 complement(185208..186326) 1 NC_007880.1 hypothetical protein 186326 3951851 FTL_0186 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512981.1 185208 R 376619 CDS YP_512982.1 89255621 3951852 complement(186394..187134) 1 NC_007880.1 cyclohexadienyl dehydratase 187134 3951852 FTL_0187 Francisella tularensis subsp. holarctica LVS cyclohexadienyl dehydratase YP_512982.1 186394 R 376619 CDS YP_512983.1 89255622 3951853 complement(187327..188520) 1 NC_007880.1 cytochrome d terminal oxidase, polypeptide subunit II 188520 3951853 FTL_0188 Francisella tularensis subsp. holarctica LVS cytochrome d terminal oxidase, polypeptide subunit II YP_512983.1 187327 R 376619 CDS YP_512984.1 89255623 3951854 complement(188531..190285) 1 NC_007880.1 cytochrome d terminal oxidase, polypeptide subunit I 190285 3951854 FTL_0189 Francisella tularensis subsp. holarctica LVS cytochrome d terminal oxidase, polypeptide subunit I YP_512984.1 188531 R 376619 CDS YP_512985.1 89255624 3951855 complement(190738..192105) 1 NC_007880.1 major facilitator transporter 192105 3951855 FTL_0190 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_512985.1 190738 R 376619 CDS YP_512986.1 89255625 3951856 192465..193367 1 NC_007880.1 cytochrome O ubiquinol oxidase subunit II 193367 3951856 FTL_0191 Francisella tularensis subsp. holarctica LVS cytochrome O ubiquinol oxidase subunit II YP_512986.1 192465 D 376619 CDS YP_512987.1 89255626 3951857 193406..195436 1 NC_007880.1 cytochrome O ubiquinol oxidase subunit I 195436 3951857 FTL_0192 Francisella tularensis subsp. holarctica LVS cytochrome O ubiquinol oxidase subunit I YP_512987.1 193406 D 376619 CDS YP_512988.1 89255627 3951917 195433..196035 1 NC_007880.1 cytochrome O ubiquinol oxidase, subunit III 196035 3951917 FTL_0193 Francisella tularensis subsp. holarctica LVS cytochrome O ubiquinol oxidase, subunit III YP_512988.1 195433 D 376619 CDS YP_512989.1 89255628 3951918 196037..196369 1 NC_007880.1 cytochrome O ubiquinol oxidase subunit IV 196369 3951918 FTL_0194 Francisella tularensis subsp. holarctica LVS cytochrome O ubiquinol oxidase subunit IV YP_512989.1 196037 D 376619 CDS YP_512990.1 89255629 3951919 196400..197248 1 NC_007880.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 197248 3951919 FTL_0195 Francisella tularensis subsp. holarctica LVS protoheme IX farnesyltransferase YP_512990.1 196400 D 376619 CDS YP_512991.1 89255630 3951920 complement(197393..198436) 1 NC_007880.1 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 198436 3951920 FTL_0196 Francisella tularensis subsp. holarctica LVS UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_512991.1 197393 R 376619 CDS YP_512992.1 89255631 3951921 complement(198511..199206) 1 NC_007880.1 hypothetical protein 199206 3951921 FTL_0197 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512992.1 198511 R 376619 CDS YP_512993.1 89255632 3951922 complement(199206..200057) 1 NC_007880.1 pyridoxal kinase 200057 3951922 FTL_0198 Francisella tularensis subsp. holarctica LVS pyridoxal kinase YP_512993.1 199206 R 376619 CDS YP_512994.1 89255633 3951923 complement(200064..200498) 1 NC_007880.1 hypothetical protein 200498 3951923 FTL_0199 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512994.1 200064 R 376619 CDS YP_512995.1 89255634 3951924 200644..201600 1 NC_007880.1 methanol dehydrogenase regulatory protein 201600 3951924 FTL_0200 Francisella tularensis subsp. holarctica LVS methanol dehydrogenase regulatory protein YP_512995.1 200644 D 376619 CDS YP_512996.1 89255635 3951925 201613..202524 1 NC_007880.1 hypothetical protein 202524 3951925 FTL_0201 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512996.1 201613 D 376619 CDS YP_512997.1 89255636 3951926 202514..202990 1 NC_007880.1 hypothetical protein 202990 3951926 FTL_0202 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512997.1 202514 D 376619 CDS YP_512998.1 89255637 3951927 202987..203988 1 NC_007880.1 hypothetical protein 203988 3951927 FTL_0203 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512998.1 202987 D 376619 CDS YP_512999.1 89255638 3951928 203990..204988 1 NC_007880.1 hypothetical protein 204988 3951928 FTL_0204 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_512999.1 203990 D 376619 CDS YP_513000.1 89255639 3951929 204979..205713 1 NC_007880.1 hypothetical protein 205713 3951929 FTL_0205 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513000.1 204979 D 376619 CDS YP_513001.1 89255640 3951930 205703..207328 1 NC_007880.1 hypothetical protein 207328 3951930 FTL_0206 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513001.1 205703 D 376619 CDS YP_513002.1 89255641 3951931 207335..208003 1 NC_007880.1 pyrrolidone-carboxylate peptidase 208003 3951931 FTL_0207 Francisella tularensis subsp. holarctica LVS pyrrolidone-carboxylate peptidase YP_513002.1 207335 D 376619 CDS YP_513003.1 89255642 3951932 208011..208493 1 NC_007880.1 putative cytochrome c-type biogenesis protein 208493 3951932 FTL_0208 Francisella tularensis subsp. holarctica LVS putative cytochrome c-type biogenesis protein YP_513003.1 208011 D 376619 CDS YP_513004.1 89255643 3951933 208527..208964 1 NC_007880.1 DNA polymerase III subunit chi 208964 3951933 FTL_0209 Francisella tularensis subsp. holarctica LVS DNA polymerase III subunit chi YP_513004.1 208527 D 376619 CDS YP_513005.1 89255644 3951934 209096..211855 1 NC_007880.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 211855 valS 3951934 valS Francisella tularensis subsp. holarctica LVS valyl-tRNA synthetase YP_513005.1 209096 D 376619 CDS YP_513006.1 89255645 3951935 211884..212771 1 NC_007880.1 hypothetical protein 212771 3951935 FTL_0211 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513006.1 211884 D 376619 CDS YP_513007.1 89255646 3951936 212726..213652 1 NC_007880.1 hypothetical protein 213652 3951936 FTL_0212 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513007.1 212726 D 376619 CDS YP_513008.1 89255647 3951099 213927..214208 1 NC_007880.1 hypothetical protein 214208 3951099 FTL_0213 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513008.1 213927 D 376619 CDS YP_513009.1 89255648 3951100 complement(214205..215362) 1 NC_007880.1 L-lactate dehydrogenase 215362 3951100 FTL_0214 Francisella tularensis subsp. holarctica LVS L-lactate dehydrogenase YP_513009.1 214205 R 376619 CDS YP_513010.1 89255649 3951101 complement(215352..216035) 1 NC_007880.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 216035 3951101 FTL_0215 Francisella tularensis subsp. holarctica LVS dihydropteridine reductase YP_513010.1 215352 R 376619 CDS YP_513011.1 89255650 3951102 216175..216552 1 NC_007880.1 MutT/nudix family protein 216552 3951102 FTL_0216 Francisella tularensis subsp. holarctica LVS MutT/nudix family protein YP_513011.1 216175 D 376619 CDS YP_513012.1 89255651 3951103 216725..218116 1 NC_007880.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 218116 fumC 3951103 fumC Francisella tularensis subsp. holarctica LVS fumarate hydratase YP_513012.1 216725 D 376619 CDS YP_513013.1 89255652 3951104 218246..219652 1 NC_007880.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 219652 gltX 3951104 gltX Francisella tularensis subsp. holarctica LVS glutamyl-tRNA synthetase YP_513013.1 218246 D 376619 CDS YP_513014.1 89255653 3951105 219933..220616 1 NC_007880.1 hypothetical protein 220616 3951105 FTL_0219 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513014.1 219933 D 376619 CDS YP_513015.1 89255654 3951805 complement(220548..221231) 1 NC_007880.1 transposase 221231 isftu2 3951805 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513015.1 220548 R 376619 CDS YP_513016.1 89255655 3951106 221674..222966 1 NC_007880.1 amino acid permease 222966 3951106 FTL_0221 Francisella tularensis subsp. holarctica LVS amino acid permease YP_513016.1 221674 D 376619 CDS YP_513017.1 89255656 3951107 complement(223460..224383) 1 NC_007880.1 hypothetical protein 224383 3951107 FTL_0222 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513017.1 223460 R 376619 CDS YP_513018.1 89255657 3951108 complement(224465..225007) 1 NC_007880.1 dihydrofolate reductase type I 225007 3951108 FTL_0223 Francisella tularensis subsp. holarctica LVS dihydrofolate reductase type I YP_513018.1 224465 R 376619 CDS YP_513019.1 89255658 3951109 225200..225919 1 NC_007880.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 225919 rpsB 3951109 rpsB Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S2 YP_513019.1 225200 D 376619 CDS YP_513020.1 89255659 3951110 225941..226810 1 NC_007880.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 226810 tsf 3951110 tsf Francisella tularensis subsp. holarctica LVS elongation factor Ts YP_513020.1 225941 D 376619 CDS YP_513021.1 89255660 3951111 226814..227563 1 NC_007880.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 227563 pyrH 3951111 pyrH Francisella tularensis subsp. holarctica LVS uridylate kinase YP_513021.1 226814 D 376619 CDS YP_513022.1 89255661 3951112 227593..228150 1 NC_007880.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 228150 frr 3951112 frr Francisella tularensis subsp. holarctica LVS ribosome recycling factor YP_513022.1 227593 D 376619 CDS YP_513023.1 89255662 3951113 228234..228956 1 NC_007880.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 228956 3951113 FTL_0228 Francisella tularensis subsp. holarctica LVS undecaprenyl pyrophosphate synthase YP_513023.1 228234 D 376619 CDS YP_513024.1 89255663 3951114 228970..229764 1 NC_007880.1 phosphatidate cytidylyltransferase 229764 3951114 FTL_0229 Francisella tularensis subsp. holarctica LVS phosphatidate cytidylyltransferase YP_513024.1 228970 D 376619 CDS YP_513025.1 89255664 3951115 229774..230220 1 NC_007880.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 230220 dut 3951115 dut Francisella tularensis subsp. holarctica LVS deoxyuridine 5'-triphosphate nucleotidohydrolase YP_513025.1 229774 D 376619 CDS YP_513026.1 89255665 3951116 230224..230820 1 NC_007880.1 phosphatidylglycerophosphate synthetase 230820 3951116 FTL_0231 Francisella tularensis subsp. holarctica LVS phosphatidylglycerophosphate synthetase YP_513026.1 230224 D 376619 CDS YP_513027.1 89255666 3951117 230955..231329 1 NC_007880.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 231329 rpsL 3951117 rpsL Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S12 YP_513027.1 230955 D 376619 CDS YP_513028.1 89255667 3952404 231368..231841 1 NC_007880.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 231841 3952404 FTL_0233 Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S7 YP_513028.1 231368 D 376619 CDS YP_513029.1 89255668 3952405 231856..233970 1 NC_007880.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 233970 3952405 FTL_0234 Francisella tularensis subsp. holarctica LVS elongation factor G YP_513029.1 231856 D 376619 CDS YP_513030.1 89255669 3952406 233991..234308 1 NC_007880.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 234308 rpsJ 3952406 rpsJ Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S10 YP_513030.1 233991 D 376619 CDS YP_513031.1 89255670 3952407 234412..235044 1 NC_007880.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 235044 rplC 3952407 rplC Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L3 YP_513031.1 234412 D 376619 CDS YP_513032.1 89255671 3952408 235077..235700 1 NC_007880.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 235700 rplD 3952408 rplD Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L4 YP_513032.1 235077 D 376619 CDS YP_513033.1 89255672 3952409 235697..235996 1 NC_007880.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 235996 rplW 3952409 rplW Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L23 YP_513033.1 235697 D 376619 CDS YP_513034.1 89255673 3952410 236018..236842 1 NC_007880.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 236842 rplB 3952410 rplB Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L2 YP_513034.1 236018 D 376619 CDS YP_513035.1 89255674 3952411 236857..237135 1 NC_007880.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 237135 rpsS 3952411 rpsS Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S19 YP_513035.1 236857 D 376619 CDS YP_513036.1 89255675 3952412 237151..237486 1 NC_007880.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 237486 rplV 3952412 rplV Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L22 YP_513036.1 237151 D 376619 CDS YP_513037.1 89255676 3952413 237501..238172 1 NC_007880.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 238172 rpsC 3952413 rpsC Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S3 YP_513037.1 237501 D 376619 CDS YP_513038.1 89255677 3952414 238172..238585 1 NC_007880.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 238585 rplP 3952414 rplP Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L16 YP_513038.1 238172 D 376619 CDS YP_513039.1 89255678 3952415 238585..238785 1 NC_007880.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 238785 3952415 FTL_0244 Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L29 YP_513039.1 238585 D 376619 CDS YP_513040.1 89255679 3952416 238798..239049 1 NC_007880.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 239049 rpsQ 3952416 rpsQ Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S17 YP_513040.1 238798 D 376619 CDS YP_513041.1 89255680 3952417 239141..239509 1 NC_007880.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 239509 rplN 3952417 rplN Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L14 YP_513041.1 239141 D 376619 CDS YP_513042.1 89255681 3952418 239531..239848 1 NC_007880.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 239848 rplX 3952418 rplX Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L24 YP_513042.1 239531 D 376619 CDS YP_513043.1 89255682 3952419 239860..240399 1 NC_007880.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 240399 rplE 3952419 rplE Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L5 YP_513043.1 239860 D 376619 CDS YP_513044.1 89255683 3952420 240418..240723 1 NC_007880.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 240723 rpsN 3952420 rpsN Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S14 YP_513044.1 240418 D 376619 CDS YP_513045.1 89255684 3952421 240740..241138 1 NC_007880.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 241138 rpsH 3952421 rpsH Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S8 YP_513045.1 240740 D 376619 CDS YP_513046.1 89255685 3952422 241157..241693 1 NC_007880.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 241693 rplF 3952422 rplF Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L6 YP_513046.1 241157 D 376619 CDS YP_513047.1 89255686 3952423 241716..242069 1 NC_007880.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 242069 rplR 3952423 rplR Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L18 YP_513047.1 241716 D 376619 CDS YP_513048.1 89255687 3951275 242097..242597 1 NC_007880.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 242597 rpsE 3951275 rpsE Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S5 YP_513048.1 242097 D 376619 CDS YP_513049.1 89255688 3951276 242604..242789 1 NC_007880.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 242789 rpmD 3951276 rpmD Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L30 YP_513049.1 242604 D 376619 CDS YP_513050.1 89255689 3951277 242796..243227 1 NC_007880.1 late assembly protein; 50S ribosomal protein L15 243227 rplO 3951277 rplO Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L15 YP_513050.1 242796 D 376619 CDS YP_513051.1 89255690 3951278 243238..244563 1 NC_007880.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 244563 secY 3951278 secY Francisella tularensis subsp. holarctica LVS preprotein translocase subunit SecY YP_513051.1 243238 D 376619 CDS YP_513052.1 89255691 3951279 244587..244700 1 NC_007880.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 244700 rpmJ 3951279 rpmJ Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L36 YP_513052.1 244587 D 376619 CDS YP_513053.1 89255692 3951280 244817..245173 1 NC_007880.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 245173 rpsM 3951280 rpsM Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S13 YP_513053.1 244817 D 376619 CDS YP_513054.1 89255693 3951281 245212..245601 1 NC_007880.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 245601 3951281 FTL_0259 Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S11 YP_513054.1 245212 D 376619 CDS YP_513055.1 89255694 3951282 245623..246243 1 NC_007880.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 246243 rpsD 3951282 rpsD Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S4 YP_513055.1 245623 D 376619 CDS YP_513056.1 89255695 3951283 246301..247272 1 NC_007880.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 247272 3951283 FTL_0261 Francisella tularensis subsp. holarctica LVS DNA-directed RNA polymerase subunit alpha YP_513056.1 246301 D 376619 CDS YP_513057.1 89255696 3951284 247317..247754 1 NC_007880.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 247754 rplQ 3951284 rplQ Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L17 YP_513057.1 247317 D 376619 CDS YP_513058.1 89255697 3951482 join(247908..248234,248234..248734) 1 NC_007880.1 transposase 248734 isftu1 3951482 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513058.1 247908 D 376619 CDS YP_513059.1 89255698 3951286 249570..250565 1 NC_007880.1 hypothetical protein 250565 3951286 FTL_0265 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513059.1 249570 D 376619 CDS YP_513060.1 89255699 3951483 complement(join(250761..251315,251315..251641)) 1 NC_007880.1 transposase 251641 isftu1 3951483 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513060.1 250761 R 376619 CDS YP_513061.1 89255700 3951287 251803..253689 1 NC_007880.1 molecular chaperone; heat shock protein 90 253689 3951287 FTL_0267 Francisella tularensis subsp. holarctica LVS heat shock protein 90 YP_513061.1 251803 D 376619 CDS YP_513062.1 89255701 3951484 complement(join(253919..254473,254473..254799)) 1 NC_007880.1 transposase 254799 isftu1 3951484 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513062.1 253919 R 376619 CDS YP_513063.1 89255702 3951288 complement(254991..256340) 1 NC_007880.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 256340 3951288 FTL_0269 Francisella tularensis subsp. holarctica LVS glutamate dehydrogenase YP_513063.1 254991 R 376619 CDS YP_513064.1 89255703 3951806 256826..257488 1 NC_007880.1 transposase 257488 isftu2 3951806 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513064.1 256826 D 376619 CDS YP_513065.1 89255704 3951289 257786..258376 1 NC_007880.1 hypothetical protein 258376 3951289 FTL_0271 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513065.1 257786 D 376619 CDS YP_513066.1 89255705 3951290 258389..259558 1 NC_007880.1 diaminopimelate decarboxylase 259558 3951290 FTL_0272 Francisella tularensis subsp. holarctica LVS diaminopimelate decarboxylase YP_513066.1 258389 D 376619 CDS YP_513067.1 89255706 3951291 259570..260949 1 NC_007880.1 glutamate/gamma-aminobutyrate anti-porter 260949 3951291 FTL_0273 Francisella tularensis subsp. holarctica LVS glutamate/gamma-aminobutyrate anti-porter YP_513067.1 259570 D 376619 CDS YP_513068.1 89255707 3951293 complement(261426..261998) 1 NC_007880.1 methylated-DNA--protein-cysteine methyltransferase 261998 3951293 FTL_0275 Francisella tularensis subsp. holarctica LVS methylated-DNA--protein-cysteine methyltransferase YP_513068.1 261426 R 376619 CDS YP_513069.1 89255708 3951313 262028..262747 1 NC_007880.1 hypothetical protein 262747 3951313 FTL_0276 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513069.1 262028 D 376619 CDS YP_513070.1 89255709 3951314 262750..264168 1 NC_007880.1 mercuric reductase protein 264168 3951314 FTL_0277 Francisella tularensis subsp. holarctica LVS mercuric reductase protein YP_513070.1 262750 D 376619 CDS YP_513071.1 89255710 3951315 264165..264764 1 NC_007880.1 hypothetical protein 264764 3951315 FTL_0278 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513071.1 264165 D 376619 CDS YP_513072.1 89255711 3951316 264761..265090 1 NC_007880.1 hypothetical protein 265090 3951316 FTL_0279 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513072.1 264761 D 376619 CDS YP_513073.1 89255712 3951317 complement(265160..265876) 1 NC_007880.1 amino acid permease 265876 3951317 FTL_0280 Francisella tularensis subsp. holarctica LVS amino acid permease YP_513073.1 265160 R 376619 CDS YP_513074.1 89255713 3951318 266075..267001 1 NC_007880.1 heat shock protein, hsp40 267001 3951318 FTL_0281 Francisella tularensis subsp. holarctica LVS heat shock protein, hsp40 YP_513074.1 266075 D 376619 CDS YP_513075.1 89255714 3951319 complement(266991..267875) 1 NC_007880.1 hypothetical protein 267875 3951319 FTL_0282 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513075.1 266991 R 376619 CDS YP_513076.1 89255715 3951320 268066..269262 1 NC_007880.1 aromatic amino acid HAAP transporter 269262 3951320 FTL_0283 Francisella tularensis subsp. holarctica LVS aromatic amino acid HAAP transporter YP_513076.1 268066 D 376619 CDS YP_513077.1 89255716 3951321 269296..269652 1 NC_007880.1 hypothetical protein 269652 3951321 FTL_0284 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513077.1 269296 D 376619 CDS YP_513078.1 89255717 3951322 270021..271964 1 NC_007880.1 GTP pyrophosphokinase 271964 3951322 FTL_0285 Francisella tularensis subsp. holarctica LVS GTP pyrophosphokinase YP_513078.1 270021 D 376619 CDS YP_513079.1 89255718 3951323 complement(272080..272712) 1 NC_007880.1 hypothetical protein 272712 3951323 FTL_0286 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513079.1 272080 R 376619 CDS YP_513080.1 89255719 3951324 complement(272789..273367) 1 NC_007880.1 hypothetical protein 273367 3951324 FTL_0287 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513080.1 272789 R 376619 CDS YP_513081.1 89255720 3951325 273455..274069 1 NC_007880.1 hypothetical protein 274069 3951325 FTL_0288 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513081.1 273455 D 376619 CDS YP_513082.1 89255721 3951326 complement(274076..274801) 1 NC_007880.1 hypothetical protein 274801 3951326 FTL_0289 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513082.1 274076 R 376619 CDS YP_513083.1 89255722 3951327 complement(274801..275679) 1 NC_007880.1 integrase/recombinase XerC 275679 3951327 FTL_0290 Francisella tularensis subsp. holarctica LVS integrase/recombinase XerC YP_513083.1 274801 R 376619 CDS YP_513084.1 89255723 3951328 complement(275689..276900) 1 NC_007880.1 aromatic amino acid HAAP transporter 276900 3951328 FTL_0291 Francisella tularensis subsp. holarctica LVS aromatic amino acid HAAP transporter YP_513084.1 275689 R 376619 CDS YP_513085.1 89255724 3951330 complement(278340..278783) 1 NC_007880.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 278783 3951330 FTL_0293 Francisella tularensis subsp. holarctica LVS preprotein translocase subunit SecB YP_513085.1 278340 R 376619 CDS YP_513086.1 89255725 3951331 complement(278860..281394) 1 NC_007880.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 281394 3951331 FTL_0294 Francisella tularensis subsp. holarctica LVS DNA mismatch repair protein MutS YP_513086.1 278860 R 376619 CDS YP_513087.1 89255726 3951332 281561..282508 1 NC_007880.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 282508 3951332 FTL_0295 Francisella tularensis subsp. holarctica LVS acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_513087.1 281561 D 376619 CDS YP_513088.1 89255727 3950858 282528..283031 1 NC_007880.1 hypothetical protein 283031 3950858 FTL_0296 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513088.1 282528 D 376619 CDS YP_513089.1 89255728 3950859 283012..284025 1 NC_007880.1 hypothetical protein 284025 3950859 FTL_0297 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513089.1 283012 D 376619 CDS YP_513090.1 89255729 3950860 284034..285995 1 NC_007880.1 hypothetical protein 285995 3950860 FTL_0298 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513090.1 284034 D 376619 CDS YP_513091.1 89255730 3950861 285992..286876 1 NC_007880.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 286876 murQ 3950861 murQ Francisella tularensis subsp. holarctica LVS N-acetylmuramic acid 6-phosphate etherase YP_513091.1 285992 D 376619 CDS YP_513092.1 89255731 3950862 286878..287273 1 NC_007880.1 hypothetical protein 287273 3950862 FTL_0300 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513092.1 286878 D 376619 CDS YP_513093.1 89255732 3950863 287858..288310 1 NC_007880.1 hypothetical protein 288310 3950863 FTL_0301 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513093.1 287858 D 376619 CDS YP_513094.1 89255733 3951807 288518..289111 1 NC_007880.1 transposase 289111 isftu2 3951807 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513094.1 288518 D 376619 CDS YP_513095.1 89255734 3950864 289108..289662 1 NC_007880.1 hypothetical protein 289662 3950864 FTL_0303 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513095.1 289108 D 376619 CDS YP_513096.1 89255735 3950865 complement(290059..291357) 1 NC_007880.1 Na+/H+ antiporter 291357 3950865 FTL_0304 Francisella tularensis subsp. holarctica LVS Na+/H+ antiporter YP_513096.1 290059 R 376619 CDS YP_513097.1 89255736 3950866 complement(291367..292092) 1 NC_007880.1 hypothetical protein 292092 3950866 FTL_0305 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513097.1 291367 R 376619 CDS YP_513098.1 89255737 3950867 complement(292094..293098) 1 NC_007880.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 293098 3950867 FTL_0306 Francisella tularensis subsp. holarctica LVS tryptophanyl-tRNA synthetase YP_513098.1 292094 R 376619 CDS YP_513099.1 89255738 3950868 complement(293395..294009) 1 NC_007880.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 294009 coaE 3950868 coaE Francisella tularensis subsp. holarctica LVS dephospho-CoA kinase YP_513099.1 293395 R 376619 CDS YP_513100.1 89255739 3950869 294207..295274 1 NC_007880.1 hypothetical protein 295274 3950869 FTL_0308 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513100.1 294207 D 376619 CDS YP_513101.1 89255740 3950870 295558..298239 1 NC_007880.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 298239 aceE 3950870 aceE Francisella tularensis subsp. holarctica LVS pyruvate dehydrogenase subunit E1 YP_513101.1 295558 D 376619 CDS YP_513102.1 89255741 3950871 298257..299852 1 NC_007880.1 dihydrolipoamide acetyltransferase 299852 3950871 FTL_0310 Francisella tularensis subsp. holarctica LVS dihydrolipoamide acetyltransferase YP_513102.1 298257 D 376619 CDS YP_513103.1 89255742 3950872 299866..301278 1 NC_007880.1 dihydrolipoamide dehydrogenase 301278 3950872 FTL_0311 Francisella tularensis subsp. holarctica LVS dihydrolipoamide dehydrogenase YP_513103.1 299866 D 376619 CDS YP_513104.1 89255743 3950873 complement(301298..301432) 1 NC_007880.1 transposase 301432 3950873 FTL_0312 Francisella tularensis subsp. holarctica LVS transposase YP_513104.1 301298 R 376619 CDS YP_513105.1 89255744 3950874 complement(301517..301657) 1 NC_007880.1 hypothetical protein 301657 3950874 FTL_0313 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513105.1 301517 R 376619 CDS YP_513106.1 89257203 3951485 join(301648..302025,302016..302528) 1 NC_007880.1 transposase 302528 isftu1 3951485 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513106.1 301648 D 376619 CDS YP_513107.1 89255745 3950875 302656..303303 1 NC_007880.1 MutT protein 303303 3950875 FTL_0315 Francisella tularensis subsp. holarctica LVS MutT protein YP_513107.1 302656 D 376619 CDS YP_513108.1 89255746 3950876 303321..303674 1 NC_007880.1 arsenate reductase 303674 3950876 FTL_0316 Francisella tularensis subsp. holarctica LVS arsenate reductase YP_513108.1 303321 D 376619 CDS YP_513109.1 89255747 3951157 complement(303698..304033) 1 NC_007880.1 hypothetical protein 304033 3951157 FTL_0317 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513109.1 303698 R 376619 CDS YP_513110.1 89255748 3951158 complement(304210..304455) 1 NC_007880.1 lipoprotein 304455 3951158 FTL_0318 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513110.1 304210 R 376619 CDS YP_513111.1 89255749 3951159 complement(304533..305846) 1 NC_007880.1 hypothetical protein 305846 3951159 FTL_0319 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513111.1 304533 R 376619 CDS YP_513112.1 89255750 3951160 complement(305982..307499) 1 NC_007880.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 307499 3951160 FTL_0320 Francisella tularensis subsp. holarctica LVS aspartate aminotransferase YP_513112.1 305982 R 376619 CDS YP_513113.1 89255751 3951165 complement(310408..311661) 1 NC_007880.1 OmpA family protein 311661 3951165 FTL_0325 Francisella tularensis subsp. holarctica LVS OmpA family protein YP_513113.1 310408 R 376619 CDS YP_513114.1 89255752 3951166 311853..312317 1 NC_007880.1 FKBP-type 16 kDa peptidyl-prolyl cis-transisomerase 312317 3951166 FTL_0326 Francisella tularensis subsp. holarctica LVS FKBP-type 16 kDa peptidyl-prolyl cis-transisomerase YP_513114.1 311853 D 376619 CDS YP_513115.1 89255753 3951167 312298..313254 1 NC_007880.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 313254 ispH 3951167 ispH Francisella tularensis subsp. holarctica LVS 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_513115.1 312298 D 376619 CDS YP_513116.1 89255754 3951168 313256..313618 1 NC_007880.1 chorismate mutase 313618 3951168 FTL_0328 Francisella tularensis subsp. holarctica LVS chorismate mutase YP_513116.1 313256 D 376619 CDS YP_513117.1 89255755 3951169 313633..314448 1 NC_007880.1 CDP-alcohol phosphatidyltransferase 314448 3951169 FTL_0329 Francisella tularensis subsp. holarctica LVS CDP-alcohol phosphatidyltransferase YP_513117.1 313633 D 376619 CDS YP_513118.1 89255756 3951170 complement(314453..314659) 1 NC_007880.1 hypothetical protein 314659 3951170 FTL_0330 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513118.1 314453 R 376619 CDS YP_513119.1 89255757 3951171 314829..315536 1 NC_007880.1 TolQ protein 315536 3951171 FTL_0331 Francisella tularensis subsp. holarctica LVS TolQ protein YP_513119.1 314829 D 376619 CDS YP_513120.1 89255758 3951172 315552..315992 1 NC_007880.1 TolR protein 315992 3951172 FTL_0332 Francisella tularensis subsp. holarctica LVS TolR protein YP_513120.1 315552 D 376619 CDS YP_513121.1 89255759 3951173 315979..316890 1 NC_007880.1 hypothetical protein 316890 3951173 FTL_0333 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513121.1 315979 D 376619 CDS YP_513122.1 89255760 3951174 316902..318209 1 NC_007880.1 TolB protein precursor 318209 3951174 FTL_0334 Francisella tularensis subsp. holarctica LVS TolB protein precursor YP_513122.1 316902 D 376619 CDS YP_513123.1 89255761 3951175 318219..318464 1 NC_007880.1 lipoprotein 318464 3951175 FTL_0335 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513123.1 318219 D 376619 CDS YP_513124.1 89255762 3951176 318483..319106 1 NC_007880.1 peptidoglycan-associated lipoprotein 319106 3951176 FTL_0336 Francisella tularensis subsp. holarctica LVS peptidoglycan-associated lipoprotein YP_513124.1 318483 D 376619 CDS YP_513125.1 89255763 3952684 320517..320867 1 NC_007880.1 N-acetyltransferase GCN5 320867 3952684 FTL_0338 Francisella tularensis subsp. holarctica LVS N-acetyltransferase GCN5 YP_513125.1 320517 D 376619 CDS YP_513126.1 89255764 3951486 join(321013..321337,321337..321893) 1 NC_007880.1 transposase 321893 isftu1 3951486 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513126.1 321013 D 376619 CDS YP_513127.1 89255765 3952685 321865..322074 1 NC_007880.1 hypothetical protein 322074 3952685 FTL_0340 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513127.1 321865 D 376619 CDS YP_513128.1 89255766 3952686 322181..322786 1 NC_007880.1 deoxyribodipyrimidine photolyase 322786 3952686 FTL_0341 Francisella tularensis subsp. holarctica LVS deoxyribodipyrimidine photolyase YP_513128.1 322181 D 376619 CDS YP_513129.1 89255767 3952687 322844..323338 1 NC_007880.1 deoxyribodipyrimidine photolyase 323338 3952687 FTL_0342 Francisella tularensis subsp. holarctica LVS deoxyribodipyrimidine photolyase YP_513129.1 322844 D 376619 CDS YP_513130.1 89255768 3952688 323554..325083 1 NC_007880.1 hypothetical protein 325083 3952688 FTL_0343 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513130.1 323554 D 376619 CDS YP_513131.1 89255769 3952689 325080..325217 1 NC_007880.1 hypothetical protein 325217 3952689 FTL_0344 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513131.1 325080 D 376619 CDS YP_513132.1 89255770 3952690 325343..326275 1 NC_007880.1 bile acid symporter family protein 326275 3952690 FTL_0345 Francisella tularensis subsp. holarctica LVS bile acid symporter family protein YP_513132.1 325343 D 376619 CDS YP_513133.1 89255771 3952691 326342..326839 1 NC_007880.1 hypothetical protein 326839 3952691 FTL_0346 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513133.1 326342 D 376619 CDS YP_513134.1 89255772 3952692 326969..327547 1 NC_007880.1 hypothetical protein 327547 3952692 FTL_0347 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513134.1 326969 D 376619 CDS YP_513135.1 89255773 3952697 complement(330636..331061) 1 NC_007880.1 hypothetical protein 331061 3952697 FTL_0352 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513135.1 330636 R 376619 CDS YP_513136.1 89255774 3952462 complement(join(331033..331587,331587..331913)) 1 NC_007880.1 transposase 331913 isftu1 3952462 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513136.1 331033 R 376619 CDS YP_513137.1 89255775 3952698 complement(332031..332390) 1 NC_007880.1 hypothetical protein 332390 3952698 FTL_0354 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513137.1 332031 R 376619 CDS YP_513138.1 89255776 3952699 complement(332404..333258) 1 NC_007880.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; 4-hydroxybenzoate polyprenyltransferase 333258 ubiA 3952699 ubiA Francisella tularensis subsp. holarctica LVS 4-hydroxybenzoate polyprenyltransferase YP_513138.1 332404 R 376619 CDS YP_513139.1 89255777 3952700 complement(333261..333767) 1 NC_007880.1 hypothetical protein 333767 3952700 FTL_0356 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513139.1 333261 R 376619 CDS YP_513140.1 89255778 3952701 333866..334573 1 NC_007880.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 334573 rph 3952701 rph Francisella tularensis subsp. holarctica LVS ribonuclease PH YP_513140.1 333866 D 376619 CDS YP_513141.1 89255779 3951623 complement(334627..334950) 1 NC_007880.1 hypothetical protein 334950 3951623 FTL_0358 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513141.1 334627 R 376619 CDS YP_513142.1 89255780 3951624 complement(335055..335957) 1 NC_007880.1 Type IV pili fiber building block protein 335957 3951624 FTL_0359 Francisella tularensis subsp. holarctica LVS Type IV pili fiber building block protein YP_513142.1 335055 R 376619 CDS YP_513143.1 89255781 3951625 complement(336062..337135) 1 NC_007880.1 putative metalloprotease; heat shock protein HtpX 337135 3951625 FTL_0360 Francisella tularensis subsp. holarctica LVS heat shock protein HtpX YP_513143.1 336062 R 376619 CDS YP_513144.1 89255782 3951626 complement(337139..337714) 1 NC_007880.1 LemA-like protein 337714 3951626 FTL_0361 Francisella tularensis subsp. holarctica LVS LemA-like protein YP_513144.1 337139 R 376619 CDS YP_513145.1 89255783 3951808 340774..341436 1 NC_007880.1 transposase 341436 isftu2 3951808 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513145.1 340774 D 376619 CDS YP_513146.1 89255784 3951634 complement(342870..343169) 1 NC_007880.1 arsenical restistance operon repressor 343169 3951634 FTL_0370 Francisella tularensis subsp. holarctica LVS arsenical restistance operon repressor YP_513146.1 342870 R 376619 CDS YP_513147.1 89255785 3951635 343378..344031 1 NC_007880.1 hypothetical protein 344031 3951635 FTL_0371 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513147.1 343378 D 376619 CDS YP_513148.1 89255786 3951636 344351..345349 1 NC_007880.1 NAD(P)+; catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 345349 gpsA 3951636 gpsA Francisella tularensis subsp. holarctica LVS NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_513148.1 344351 D 376619 CDS YP_513149.1 89255787 3951637 complement(345350..345886) 1 NC_007880.1 hypothetical protein 345886 3951637 FTL_0373 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513149.1 345350 R 376619 CDS YP_513150.1 89255788 3951638 complement(345891..347261) 1 NC_007880.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 347261 3951638 FTL_0374 Francisella tularensis subsp. holarctica LVS DNA repair protein RadA YP_513150.1 345891 R 376619 CDS YP_513151.1 89255789 3951639 complement(347269..348039) 1 NC_007880.1 hypothetical protein 348039 3951639 FTL_0375 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513151.1 347269 R 376619 CDS YP_513152.1 89255790 3951640 complement(348036..348635) 1 NC_007880.1 hypothetical protein 348635 3951640 FTL_0376 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513152.1 348036 R 376619 CDS YP_513153.1 89255791 3951641 complement(348638..349696) 1 NC_007880.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 349696 3951641 FTL_0377 Francisella tularensis subsp. holarctica LVS chorismate synthase YP_513153.1 348638 R 376619 CDS YP_513154.1 89255792 3951642 complement(349837..350490) 1 NC_007880.1 hypothetical protein 350490 3951642 FTL_0378 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513154.1 349837 R 376619 CDS YP_513155.1 89255793 3952559 complement(350509..351021) 1 NC_007880.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 351021 3952559 FTL_0379 Francisella tularensis subsp. holarctica LVS methionine sulfoxide reductase B YP_513155.1 350509 R 376619 CDS YP_513156.1 89255794 3952560 351182..351739 1 NC_007880.1 superoxide dismuate (Cu-Zn) precusor 351739 3952560 FTL_0380 Francisella tularensis subsp. holarctica LVS superoxide dismuate (Cu-Zn) precusor YP_513156.1 351182 D 376619 CDS YP_513157.1 89255795 3952561 351743..352534 1 NC_007880.1 hypothetical protein 352534 3952561 FTL_0381 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513157.1 351743 D 376619 CDS YP_513158.1 89255796 3952562 complement(352509..353903) 1 NC_007880.1 amino acid permease 353903 3952562 FTL_0382 Francisella tularensis subsp. holarctica LVS amino acid permease YP_513158.1 352509 R 376619 CDS YP_513159.1 89255797 3952563 354053..354415 1 NC_007880.1 mannose-6-phosphate isomerase, fragment 354415 3952563 FTL_0383 Francisella tularensis subsp. holarctica LVS mannose-6-phosphate isomerase, fragment YP_513159.1 354053 D 376619 CDS YP_513160.1 89255798 3952567 complement(355654..356844) 1 NC_007880.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 356844 3952567 FTL_0387 Francisella tularensis subsp. holarctica LVS aspartate aminotransferase YP_513160.1 355654 R 376619 CDS YP_513161.1 89255799 3952568 357047..357934 1 NC_007880.1 cation transporter 357934 3952568 FTL_0388 Francisella tularensis subsp. holarctica LVS cation transporter YP_513161.1 357047 D 376619 CDS YP_513162.1 89255800 3952569 358020..359669 1 NC_007880.1 DNA repair protein recN 359669 3952569 FTL_0389 Francisella tularensis subsp. holarctica LVS DNA repair protein recN YP_513162.1 358020 D 376619 CDS YP_513163.1 89255801 3952570 complement(359970..361055) 1 NC_007880.1 Type IV pili fiber building block protein 361055 3952570 FTL_0390 Francisella tularensis subsp. holarctica LVS Type IV pili fiber building block protein YP_513163.1 359970 R 376619 CDS YP_513164.1 89255802 3952571 complement(360979..361203) 1 NC_007880.1 hypothetical protein 361203 3952571 FTL_0391 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513164.1 360979 R 376619 CDS YP_513165.1 89255803 3952572 complement(362203..362313) 1 NC_007880.1 Type IV pili fiber building block protein 362313 3952572 FTL_0392 Francisella tularensis subsp. holarctica LVS Type IV pili fiber building block protein YP_513165.1 362203 R 376619 CDS YP_513166.1 89255804 3952573 362697..363416 1 NC_007880.1 hypothetical protein 363416 3952573 FTL_0393 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513166.1 362697 D 376619 CDS YP_513167.1 89255805 3952574 363556..364404 1 NC_007880.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 364404 3952574 FTL_0394 Francisella tularensis subsp. holarctica LVS bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_513167.1 363556 D 376619 CDS YP_513168.1 89255806 3952575 364624..365667 1 NC_007880.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 365667 3952575 FTL_0395 Francisella tularensis subsp. holarctica LVS phosphoribosylaminoimidazole synthetase YP_513168.1 364624 D 376619 CDS YP_513169.1 89255807 3952576 365667..367979 1 NC_007880.1 fusion protein PurC/PurD 367979 3952576 FTL_0396 Francisella tularensis subsp. holarctica LVS fusion protein PurC/PurD YP_513169.1 365667 D 376619 CDS YP_513170.1 89255808 3952577 367983..368558 1 NC_007880.1 phosphoribosylglycinamide formyltransferase 368558 3952577 FTL_0397 Francisella tularensis subsp. holarctica LVS phosphoribosylglycinamide formyltransferase YP_513170.1 367983 D 376619 CDS YP_513171.1 89255809 3952326 368675..369166 1 NC_007880.1 phosphoribosylaminoimidazole carboxylase,catalyic subunit 369166 3952326 FTL_0398 Francisella tularensis subsp. holarctica LVS phosphoribosylaminoimidazole carboxylase,catalyic subunit YP_513171.1 368675 D 376619 CDS YP_513172.1 89255810 3952327 369170..370267 1 NC_007880.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 370267 3952327 FTL_0399 Francisella tularensis subsp. holarctica LVS phosphoribosylaminoimidazole carboxylase ATPase subunit YP_513172.1 369170 D 376619 CDS YP_513173.1 89255811 3951809 complement(370444..371070) 1 NC_007880.1 transposase 371070 isftu2 3951809 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513173.1 370444 R 376619 CDS YP_513174.1 89255812 3952328 complement(371278..371643) 1 NC_007880.1 Sua5_yciO_yrdC family protein 371643 3952328 FTL_0401 Francisella tularensis subsp. holarctica LVS Sua5_yciO_yrdC family protein YP_513174.1 371278 R 376619 CDS YP_513175.1 89255813 3952329 371704..372234 1 NC_007880.1 intracellular septation protein A family protein 372234 3952329 FTL_0402 Francisella tularensis subsp. holarctica LVS intracellular septation protein A family protein YP_513175.1 371704 D 376619 CDS YP_513176.1 89255814 3952330 372308..372559 1 NC_007880.1 hypothetical protein 372559 3952330 FTL_0403 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513176.1 372308 D 376619 CDS YP_513177.1 89255815 3952331 complement(372548..373564) 1 NC_007880.1 glucose kinase 373564 3952331 FTL_0404 Francisella tularensis subsp. holarctica LVS glucose kinase YP_513177.1 372548 R 376619 CDS YP_513178.1 89255816 3952332 373658..374410 1 NC_007880.1 menaquinone biosynthesis methyltransferase 374410 3952332 FTL_0405 Francisella tularensis subsp. holarctica LVS menaquinone biosynthesis methyltransferase YP_513178.1 373658 D 376619 CDS YP_513179.1 89255817 3952333 374412..374999 1 NC_007880.1 hypothetical protein 374999 3952333 FTL_0406 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513179.1 374412 D 376619 CDS YP_513180.1 89255818 3952334 374992..376650 1 NC_007880.1 2-polyprenylphenol 6-hydroxylase 376650 3952334 FTL_0407 Francisella tularensis subsp. holarctica LVS 2-polyprenylphenol 6-hydroxylase YP_513180.1 374992 D 376619 CDS YP_513181.1 89255819 3952335 376656..376994 1 NC_007880.1 histidine triad (HIT) family protein 376994 3952335 FTL_0408 Francisella tularensis subsp. holarctica LVS histidine triad (HIT) family protein YP_513181.1 376656 D 376619 CDS YP_513182.1 89255820 3952336 complement(377509..378162) 1 NC_007880.1 purine/pyrimidine phosphoribosyl transferase family protein 378162 3952336 FTL_0409 Francisella tularensis subsp. holarctica LVS purine/pyrimidine phosphoribosyl transferase family protein YP_513182.1 377509 R 376619 CDS YP_513183.1 89255821 3952337 378140..378967 1 NC_007880.1 hypothetical protein 378967 3952337 FTL_0410 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513183.1 378140 D 376619 CDS YP_513184.1 89255822 3952338 complement(378969..379844) 1 NC_007880.1 hypothetical protein 379844 3952338 FTL_0411 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513184.1 378969 R 376619 CDS YP_513185.1 89255823 3952339 complement(379923..380771) 1 NC_007880.1 UDP-N-acetylenolpyruvoylglucosamine reductase 380771 3952339 FTL_0412 Francisella tularensis subsp. holarctica LVS UDP-N-acetylenolpyruvoylglucosamine reductase YP_513185.1 379923 R 376619 CDS YP_513186.1 89255824 3952340 complement(380779..382083) 1 NC_007880.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase 382083 3952340 FTL_0413 Francisella tularensis subsp. holarctica LVS UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_513186.1 380779 R 376619 CDS YP_513187.1 89255825 3952341 complement(382052..383449) 1 NC_007880.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 383449 engA 3952341 engA Francisella tularensis subsp. holarctica LVS GTP-binding protein EngA YP_513187.1 382052 R 376619 CDS YP_513188.1 89255826 3952342 complement(383686..384204) 1 NC_007880.1 hypothetical protein 384204 3952342 FTL_0415 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513188.1 383686 R 376619 CDS YP_513189.1 89255827 3951810 384458..385270 1 NC_007880.1 transposase 385270 isftu2 3951810 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513189.1 384458 D 376619 CDS YP_513190.1 89255828 3952463 complement(join(385054..385554,385554..385880)) 1 NC_007880.1 transposase 385880 isftu1 3952463 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513190.1 385054 R 376619 CDS YP_513191.1 89255829 3952343 complement(385938..386186) 1 NC_007880.1 hypothetical protein 386186 3952343 FTL_0418 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513191.1 385938 R 376619 CDS YP_513192.1 89255830 3952344 complement(386267..388273) 1 NC_007880.1 oligopeptidase A 388273 3952344 FTL_0419 Francisella tularensis subsp. holarctica LVS oligopeptidase A YP_513192.1 386267 R 376619 CDS YP_513193.1 89255831 3952345 388365..388736 1 NC_007880.1 hypothetical protein 388736 3952345 FTL_0420 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513193.1 388365 D 376619 CDS YP_513194.1 89255832 3951237 388817..389266 1 NC_007880.1 lipoprotein 389266 3951237 FTL_0421 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513194.1 388817 D 376619 CDS YP_513195.1 89255833 3951239 389927..390430 1 NC_007880.1 hypothetical protein 390430 3951239 FTL_0423 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513195.1 389927 D 376619 CDS YP_513196.1 89255834 3951240 390463..390930 1 NC_007880.1 lipoprotein 390930 3951240 FTL_0424 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513196.1 390463 D 376619 CDS YP_513197.1 89255835 3951241 391093..392445 1 NC_007880.1 Type IV pili glycosylation protein 392445 3951241 FTL_0425 Francisella tularensis subsp. holarctica LVS Type IV pili glycosylation protein YP_513197.1 391093 D 376619 CDS YP_513198.1 89255836 3951242 complement(392499..394793) 1 NC_007880.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining; maintains net negative superhelicity; DNA topoisomerase I 394793 3951242 FTL_0426 Francisella tularensis subsp. holarctica LVS DNA topoisomerase I YP_513198.1 392499 R 376619 CDS YP_513199.1 89255837 3951243 394992..395633 1 NC_007880.1 chmomosome partition protein A 395633 3951243 FTL_0427 Francisella tularensis subsp. holarctica LVS chmomosome partition protein A YP_513199.1 394992 D 376619 CDS YP_513200.1 89255838 3951244 395626..396540 1 NC_007880.1 chromosome partition protein B 396540 3951244 FTL_0428 Francisella tularensis subsp. holarctica LVS chromosome partition protein B YP_513200.1 395626 D 376619 CDS YP_513201.1 89255839 3951245 396554..397261 1 NC_007880.1 glutamine amidotransferase 397261 3951245 FTL_0429 Francisella tularensis subsp. holarctica LVS glutamine amidotransferase YP_513201.1 396554 D 376619 CDS YP_513202.1 89255840 3951246 397264..398145 1 NC_007880.1 hypothetical protein 398145 3951246 FTL_0430 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513202.1 397264 D 376619 CDS YP_513203.1 89255841 3951247 398142..398417 1 NC_007880.1 hypothetical protein 398417 3951247 FTL_0431 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513203.1 398142 D 376619 CDS YP_513204.1 89255842 3951248 398559..398732 1 NC_007880.1 hypothetical protein 398732 3951248 FTL_0432 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513204.1 398559 D 376619 CDS YP_513205.1 89255843 3951249 complement(398792..399412) 1 NC_007880.1 ribosomal large subunit methyltransferase J 399412 3951249 FTL_0433 Francisella tularensis subsp. holarctica LVS ribosomal large subunit methyltransferase J YP_513205.1 398792 R 376619 CDS YP_513206.1 89255844 3951250 399570..400037 1 NC_007880.1 hypothetical protein 400037 3951250 FTL_0434 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513206.1 399570 D 376619 CDS YP_513207.1 89255845 3951251 complement(400032..400517) 1 NC_007880.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 400517 lspA 3951251 lspA Francisella tularensis subsp. holarctica LVS lipoprotein signal peptidase YP_513207.1 400032 R 376619 CDS YP_513208.1 89255846 3951252 complement(400504..403311) 1 NC_007880.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 403311 ileS 3951252 ileS Francisella tularensis subsp. holarctica LVS isoleucyl-tRNA synthetase YP_513208.1 400504 R 376619 CDS YP_513209.1 89255847 3951253 complement(403404..404324) 1 NC_007880.1 riboflavin biosynthesis protein RibF 404324 3951253 FTL_0437 Francisella tularensis subsp. holarctica LVS riboflavin biosynthesis protein RibF YP_513209.1 403404 R 376619 CDS YP_513210.1 89255848 3951254 404475..406289 1 NC_007880.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 406289 3951254 FTL_0438 Francisella tularensis subsp. holarctica LVS malate dehydrogenase YP_513210.1 404475 D 376619 CDS YP_513211.1 89255849 3951255 406452..408107 1 NC_007880.1 hypothetical protein 408107 3951255 FTL_0439 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513211.1 406452 D 376619 CDS YP_513212.1 89255850 3952464 join(408242..408568,408568..409071) 1 NC_007880.1 transposase 409071 isftu1 3952464 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513212.1 408242 D 376619 CDS YP_513213.1 89255851 3951811 409289..410188 1 NC_007880.1 transposase 410188 isftu2 3951811 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513213.1 409289 D 376619 CDS YP_513214.1 89255852 3952306 410238..410840 1 NC_007880.1 hypothetical protein 410840 3952306 FTL_0442 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513214.1 410238 D 376619 CDS YP_513215.1 89255853 3952307 complement(410837..412141) 1 NC_007880.1 major facilitator transporter 412141 3952307 FTL_0443 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_513215.1 410837 R 376619 CDS YP_513216.1 89255854 3952308 complement(412077..414101) 1 NC_007880.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 414101 metG 3952308 metG Francisella tularensis subsp. holarctica LVS methionyl-tRNA synthetase YP_513216.1 412077 R 376619 CDS YP_513217.1 89255855 3952309 complement(414671..415207) 1 NC_007880.1 hypothetical protein 415207 3952309 FTL_0445 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513217.1 414671 R 376619 CDS YP_513218.1 89255856 3952310 421380..421595 1 NC_007880.1 hypothetical protein 421595 3952310 FTL_0446 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513218.1 421380 D 376619 CDS YP_513219.1 89255857 3952311 complement(421977..423032) 1 NC_007880.1 hypothetical protein 423032 3952311 FTL_0447 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513219.1 421977 R 376619 CDS YP_513220.1 89255858 3952312 complement(423165..423821) 1 NC_007880.1 hypothetical protein 423821 3952312 FTL_0448 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513220.1 423165 R 376619 CDS YP_513221.1 89255859 3952313 425025..425360 1 NC_007880.1 hypothetical protein 425360 3952313 FTL_0449 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513221.1 425025 D 376619 CDS YP_513222.1 89255860 3952314 complement(425333..426184) 1 NC_007880.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 426184 psd 3952314 psd Francisella tularensis subsp. holarctica LVS phosphatidylserine decarboxylase YP_513222.1 425333 R 376619 CDS YP_513223.1 89255861 3952315 426283..427263 1 NC_007880.1 hypothetical protein 427263 3952315 FTL_0451 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513223.1 426283 D 376619 CDS YP_513224.1 89255862 3952316 427272..428315 1 NC_007880.1 NadM-Nudix subfamily; involved in creation of nicotanimide adenine dinucleotide NAD from either biosynthetic or salvage pathways; bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase 428315 3952316 FTL_0452 Francisella tularensis subsp. holarctica LVS bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase YP_513224.1 427272 D 376619 CDS YP_513225.1 89255863 3952317 428329..429696 1 NC_007880.1 UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase 429696 3952317 FTL_0453 Francisella tularensis subsp. holarctica LVS UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase YP_513225.1 428329 D 376619 CDS YP_513226.1 89255864 3952318 429717..431555 1 NC_007880.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 431555 3952318 FTL_0454 Francisella tularensis subsp. holarctica LVS glucosamine--fructose-6-phosphate aminotransferase YP_513226.1 429717 D 376619 CDS YP_513227.1 89255865 3952319 431645..432160 1 NC_007880.1 acetyltransferase 432160 3952319 FTL_0455 Francisella tularensis subsp. holarctica LVS acetyltransferase YP_513227.1 431645 D 376619 CDS YP_513228.1 89255866 3952320 complement(432157..432354) 1 NC_007880.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 432354 rpsU 3952320 rpsU Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S21 YP_513228.1 432157 R 376619 CDS YP_513229.1 89255867 3952321 complement(432354..432557) 1 NC_007880.1 cold shock protein 432557 3952321 FTL_0457 Francisella tularensis subsp. holarctica LVS cold shock protein YP_513229.1 432354 R 376619 CDS YP_513230.1 89255868 3952322 complement(432804..433133) 1 NC_007880.1 hypothetical protein 433133 3952322 FTL_0458 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513230.1 432804 R 376619 CDS YP_513231.1 89255869 3952323 433260..434030 1 NC_007880.1 methionine aminopeptidase 434030 3952323 FTL_0459 Francisella tularensis subsp. holarctica LVS methionine aminopeptidase YP_513231.1 433260 D 376619 CDS YP_513232.1 89255870 3952324 434032..434880 1 NC_007880.1 hypothetical protein 434880 3952324 FTL_0460 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513232.1 434032 D 376619 CDS YP_513233.1 89255871 3952325 434974..435639 1 NC_007880.1 hypothetical protein 435639 3952325 FTL_0461 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513233.1 434974 D 376619 CDS YP_513234.1 89255872 3952521 435772..437997 1 NC_007880.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 437997 3952521 FTL_0462 Francisella tularensis subsp. holarctica LVS DNA topoisomerase IV subunit A YP_513234.1 435772 D 376619 CDS YP_513235.1 89255873 3952522 437997..438683 1 NC_007880.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 438683 3952522 FTL_0463 Francisella tularensis subsp. holarctica LVS 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_513235.1 437997 D 376619 CDS YP_513236.1 89255874 3952523 complement(438670..439269) 1 NC_007880.1 hypothetical protein 439269 3952523 FTL_0464 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513236.1 438670 R 376619 CDS YP_513237.1 89255875 3952524 complement(439262..440380) 1 NC_007880.1 BNR/Asp-box repeat-containing protein 440380 3952524 FTL_0465 Francisella tularensis subsp. holarctica LVS BNR/Asp-box repeat-containing protein YP_513237.1 439262 R 376619 CDS YP_513238.1 89255876 3952525 440579..442555 1 NC_007880.1 soluble lytic murein transglycosylase 442555 3952525 FTL_0466 Francisella tularensis subsp. holarctica LVS soluble lytic murein transglycosylase YP_513238.1 440579 D 376619 CDS YP_513239.1 89255877 3952526 complement(442569..442838) 1 NC_007880.1 hypothetical protein 442838 3952526 FTL_0467 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513239.1 442569 R 376619 CDS YP_513240.1 89255878 3951812 complement(442789..443442) 1 NC_007880.1 transposase 443442 isftu2 3951812 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513240.1 442789 R 376619 CDS YP_513241.1 89255879 3952527 complement(443682..444065) 1 NC_007880.1 hypothetical protein 444065 3952527 FTL_0469 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513241.1 443682 R 376619 CDS YP_513242.1 89255880 3952528 444418..444801 1 NC_007880.1 hypothetical protein 444801 3952528 FTL_0470 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513242.1 444418 D 376619 CDS YP_513243.1 89255881 3952529 445158..445571 1 NC_007880.1 hypothetical protein 445571 3952529 FTL_0471 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513243.1 445158 D 376619 CDS YP_513244.1 89255882 3952530 445928..449407 1 NC_007880.1 DNA polymerase III subunit alpha 449407 3952530 FTL_0472 Francisella tularensis subsp. holarctica LVS DNA polymerase III subunit alpha YP_513244.1 445928 D 376619 CDS YP_513245.1 89255883 3952531 449483..450118 1 NC_007880.1 peptide deformylase 450118 3952531 FTL_0473 Francisella tularensis subsp. holarctica LVS peptide deformylase YP_513245.1 449483 D 376619 CDS YP_513246.1 89255884 3952532 450781..452085 1 NC_007880.1 lipoprotein releasing system, subunit C,putative membrane protein 452085 3952532 FTL_0474 Francisella tularensis subsp. holarctica LVS lipoprotein releasing system, subunit C,putative membrane protein YP_513246.1 450781 D 376619 CDS YP_513247.1 89255885 3952533 452078..452773 1 NC_007880.1 lipoprotein releasing system, subunit D, ABC transporter ATP-binding protein 452773 3952533 FTL_0475 Francisella tularensis subsp. holarctica LVS lipoprotein releasing system, subunit D, ABC transporter ATP-binding protein YP_513247.1 452078 D 376619 CDS YP_513248.1 89255886 3952534 452890..455031 1 NC_007880.1 lysine decarboxylase, inducable 455031 3952534 FTL_0476 Francisella tularensis subsp. holarctica LVS lysine decarboxylase, inducable YP_513248.1 452890 D 376619 CDS YP_513249.1 89255887 3952535 455122..456198 1 NC_007880.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 456198 gcvT 3952535 gcvT Francisella tularensis subsp. holarctica LVS glycine cleavage system aminomethyltransferase T YP_513249.1 455122 D 376619 CDS YP_513250.1 89255888 3952536 456255..456638 1 NC_007880.1 glycine cleavage system H protein 456638 3952536 FTL_0478 Francisella tularensis subsp. holarctica LVS glycine cleavage system H protein YP_513250.1 456255 D 376619 CDS YP_513251.1 89255889 3952537 456703..458070 1 NC_007880.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein; glycine dehydrogenase subunit 1 458070 3952537 FTL_0479 Francisella tularensis subsp. holarctica LVS glycine dehydrogenase subunit 1 YP_513251.1 456703 D 376619 CDS YP_513252.1 89255890 3952538 458076..459521 1 NC_007880.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; glycine dehydrogenase subunit 2 459521 3952538 FTL_0480 Francisella tularensis subsp. holarctica LVS glycine dehydrogenase subunit 2 YP_513252.1 458076 D 376619 CDS YP_513253.1 89255891 3952539 complement(459641..460486) 1 NC_007880.1 shikimate 5-dehydrogenase 460486 3952539 FTL_0481 Francisella tularensis subsp. holarctica LVS shikimate 5-dehydrogenase YP_513253.1 459641 R 376619 CDS YP_513254.1 89255892 3950980 complement(460512..463724) 1 NC_007880.1 pullulonase 463724 3950980 FTL_0482 Francisella tularensis subsp. holarctica LVS pullulonase YP_513254.1 460512 R 376619 CDS YP_513255.1 89255893 3950981 complement(463758..465680) 1 NC_007880.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 465680 3950981 FTL_0483 Francisella tularensis subsp. holarctica LVS glycogen branching protein YP_513255.1 463758 R 376619 CDS YP_513256.1 89255894 3950982 465981..467615 1 NC_007880.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 467615 3950982 FTL_0484 Francisella tularensis subsp. holarctica LVS phosphoglucomutase YP_513256.1 465981 D 376619 CDS YP_513257.1 89255895 3950983 467649..468920 1 NC_007880.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 468920 glgC 3950983 glgC Francisella tularensis subsp. holarctica LVS glucose-1-phosphate adenylyltransferase YP_513257.1 467649 D 376619 CDS YP_513258.1 89255896 3950984 468930..470399 1 NC_007880.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 470399 glgA 3950984 glgA Francisella tularensis subsp. holarctica LVS glycogen synthase YP_513258.1 468930 D 376619 CDS YP_513259.1 89255897 3950985 470504..472777 1 NC_007880.1 maltodextrin phosphorylase 472777 3950985 FTL_0487 Francisella tularensis subsp. holarctica LVS maltodextrin phosphorylase YP_513259.1 470504 D 376619 CDS YP_513260.1 89255898 3950986 472821..474284 1 NC_007880.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 474284 3950986 FTL_0488 Francisella tularensis subsp. holarctica LVS 4-alpha-glucanotransferase YP_513260.1 472821 D 376619 CDS YP_513261.1 89255899 3950987 474376..475266 1 NC_007880.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 475266 glyQ 3950987 glyQ Francisella tularensis subsp. holarctica LVS glycyl-tRNA synthetase subunit alpha YP_513261.1 474376 D 376619 CDS YP_513262.1 89255900 3950988 475477..476940 1 NC_007880.1 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 476940 3950988 FTL_0490 Francisella tularensis subsp. holarctica LVS UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_513262.1 475477 D 376619 CDS YP_513263.1 89255901 3950989 476962..477357 1 NC_007880.1 outer membrane lipoprotein 477357 3950989 FTL_0491 Francisella tularensis subsp. holarctica LVS outer membrane lipoprotein YP_513263.1 476962 D 376619 CDS YP_513264.1 89255902 3950990 477710..479068 1 NC_007880.1 UDP-N--acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase 479068 3950990 FTL_0492 Francisella tularensis subsp. holarctica LVS UDP-N--acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase YP_513264.1 477710 D 376619 CDS YP_513265.1 89255903 3950991 479077..479895 1 NC_007880.1 hypothetical protein 479895 3950991 FTL_0493 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513265.1 479077 D 376619 CDS YP_513266.1 89255904 3950992 complement(479944..480993) 1 NC_007880.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 480993 3950992 FTL_0494 Francisella tularensis subsp. holarctica LVS aspartate-semialdehyde dehydrogenase YP_513266.1 479944 R 376619 CDS YP_513267.1 89255905 3950996 482791..484083 1 NC_007880.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 484083 3950996 FTL_0498 Francisella tularensis subsp. holarctica LVS threonine synthase YP_513267.1 482791 D 376619 CDS YP_513268.1 89255906 3950997 484671..485159 1 NC_007880.1 S-adenosylmethionine decarboxylase 485159 3950997 FTL_0499 Francisella tularensis subsp. holarctica LVS S-adenosylmethionine decarboxylase YP_513268.1 484671 D 376619 CDS YP_513269.1 89255907 3950998 485159..486028 1 NC_007880.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 486028 3950998 FTL_0500 Francisella tularensis subsp. holarctica LVS spermidine synthase YP_513269.1 485159 D 376619 CDS YP_513270.1 89255908 3950999 486393..487703 1 NC_007880.1 putative arginine decarboxylase 487703 3950999 FTL_0501 Francisella tularensis subsp. holarctica LVS putative arginine decarboxylase YP_513270.1 486393 D 376619 CDS YP_513271.1 89255909 3952209 487684..488544 1 NC_007880.1 hypothetical protein 488544 3952209 FTL_0502 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513271.1 487684 D 376619 CDS YP_513272.1 89255910 3952465 complement(join(488545..489099,489099..489425)) 1 NC_007880.1 transposase 489425 isftu1 3952465 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513272.1 488545 R 376619 CDS YP_513273.1 89255911 3952210 489874..490044 1 NC_007880.1 beta-alanine synthase or beta-ureidopropionase 490044 3952210 FTL_0504 Francisella tularensis subsp. holarctica LVS beta-alanine synthase or beta-ureidopropionase YP_513273.1 489874 D 376619 CDS YP_513274.1 89255912 3952211 490114..490482 1 NC_007880.1 carbon-nitrogen hydrolase family protein 490482 3952211 FTL_0505 Francisella tularensis subsp. holarctica LVS carbon-nitrogen hydrolase family protein YP_513274.1 490114 D 376619 CDS YP_513275.1 89255913 3952212 complement(490499..491215) 1 NC_007880.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 491215 3952212 FTL_0506 Francisella tularensis subsp. holarctica LVS UDP-2,3-diacylglucosamine hydrolase YP_513275.1 490499 R 376619 CDS YP_513276.1 89255914 3952213 complement(491205..491831) 1 NC_007880.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 491831 pyrE 3952213 pyrE Francisella tularensis subsp. holarctica LVS orotate phosphoribosyltransferase YP_513276.1 491205 R 376619 CDS YP_513277.1 89255915 3952214 491991..493361 1 NC_007880.1 UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 493361 3952214 FTL_0508 Francisella tularensis subsp. holarctica LVS UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase YP_513277.1 491991 D 376619 CDS YP_513278.1 89255916 3952215 493358..494014 1 NC_007880.1 tRNA/rRNA methyltransferase 494014 3952215 FTL_0509 Francisella tularensis subsp. holarctica LVS tRNA/rRNA methyltransferase YP_513278.1 493358 D 376619 CDS YP_513279.1 89255917 3952466 complement(join(493992..494546,494546..494872)) 1 NC_007880.1 transposase 494872 isftu1 3952466 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513279.1 493992 R 376619 CDS YP_513280.1 89255918 3952216 495122..495802 1 NC_007880.1 hypothetical protein 495802 3952216 FTL_0511 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513280.1 495122 D 376619 CDS YP_513281.1 89255919 3952217 complement(496082..496318) 1 NC_007880.1 BolA-like protein 496318 3952217 FTL_0512 Francisella tularensis subsp. holarctica LVS BolA-like protein YP_513281.1 496082 R 376619 CDS YP_513282.1 89255920 3952218 complement(496335..496628) 1 NC_007880.1 hypothetical protein 496628 3952218 FTL_0513 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513282.1 496335 R 376619 CDS YP_513283.1 89255921 3952219 complement(496628..497290) 1 NC_007880.1 hypothetical protein 497290 3952219 FTL_0514 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513283.1 496628 R 376619 CDS YP_513284.1 89255922 3952220 complement(497365..497898) 1 NC_007880.1 ABC transporter substrate-binding protein 497898 3952220 FTL_0515 Francisella tularensis subsp. holarctica LVS ABC transporter substrate-binding protein YP_513284.1 497365 R 376619 CDS YP_513285.1 89255923 3952221 complement(497898..498662) 1 NC_007880.1 ABC transporter membrane protein 498662 3952221 FTL_0516 Francisella tularensis subsp. holarctica LVS ABC transporter membrane protein YP_513285.1 497898 R 376619 CDS YP_513286.1 89255924 3952222 complement(498666..499469) 1 NC_007880.1 ABC transporter ATP-binding protein 499469 3952222 FTL_0517 Francisella tularensis subsp. holarctica LVS ABC transporter ATP-binding protein YP_513286.1 498666 R 376619 CDS YP_513287.1 89255925 3952223 complement(499483..499755) 1 NC_007880.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 499755 3952223 FTL_0518 Francisella tularensis subsp. holarctica LVS cell division topological specificity factor MinE YP_513287.1 499483 R 376619 CDS YP_513288.1 89255926 3952224 complement(499758..500582) 1 NC_007880.1 septum site-determining protein MinD 500582 3952224 FTL_0519 Francisella tularensis subsp. holarctica LVS septum site-determining protein MinD YP_513288.1 499758 R 376619 CDS YP_513289.1 89255927 3952225 complement(500622..501308) 1 NC_007880.1 septum site-determining protein MinC 501308 3952225 FTL_0520 Francisella tularensis subsp. holarctica LVS septum site-determining protein MinC YP_513289.1 500622 R 376619 CDS YP_513290.1 89255928 3952226 complement(501343..501498) 1 NC_007880.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 501498 rpmG 3952226 rpmG Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L33 YP_513290.1 501343 R 376619 CDS YP_513291.1 89255929 3952227 complement(501525..501761) 1 NC_007880.1 required for 70S ribosome assembly; 50S ribosomal protein L28 501761 rpmB 3952227 rpmB Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L28 YP_513291.1 501525 R 376619 CDS YP_513292.1 89255930 3952663 complement(501895..502239) 1 NC_007880.1 hypothetical protein 502239 3952663 FTL_0523 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513292.1 501895 R 376619 CDS YP_513293.1 89255931 3952664 502369..504408 1 NC_007880.1 ATP-dependent DNA helicase RecG 504408 3952664 FTL_0524 Francisella tularensis subsp. holarctica LVS ATP-dependent DNA helicase RecG YP_513293.1 502369 D 376619 CDS YP_513294.1 89255932 3952665 505163..506677 1 NC_007880.1 fumerate hydratase 506677 3952665 FTL_0525 Francisella tularensis subsp. holarctica LVS fumerate hydratase YP_513294.1 505163 D 376619 CDS YP_513295.1 89255933 3952467 join(507162..507488,507488..507880) 1 NC_007880.1 transposase 507880 isftu1 3952467 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513295.1 507162 D 376619 CDS YP_513296.1 89255934 3952666 507885..508169 1 NC_007880.1 endonuclease 508169 3952666 FTL_0527 Francisella tularensis subsp. holarctica LVS endonuclease YP_513296.1 507885 D 376619 CDS YP_513297.1 89255935 3952667 508407..511280 1 NC_007880.1 Type III restriction enzyme 511280 3952667 FTL_0528 Francisella tularensis subsp. holarctica LVS Type III restriction enzyme YP_513297.1 508407 D 376619 CDS YP_513298.1 89255936 3952668 511277..511939 1 NC_007880.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 511939 3952668 FTL_0529 Francisella tularensis subsp. holarctica LVS uracil-DNA glycosylase YP_513298.1 511277 D 376619 CDS YP_513299.1 89255937 3952669 complement(512300..512593) 1 NC_007880.1 hypothetical protein 512593 3952669 FTL_0530 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513299.1 512300 R 376619 CDS YP_513300.1 89255938 3952670 complement(512798..513055) 1 NC_007880.1 hypothetical protein 513055 3952670 FTL_0531 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513300.1 512798 R 376619 CDS YP_513301.1 89255939 3952671 complement(513165..513635) 1 NC_007880.1 hypothetical protein 513635 3952671 FTL_0532 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513301.1 513165 R 376619 CDS YP_513302.1 89255940 3952672 513894..516500 1 NC_007880.1 DNA gyrase subunit A 516500 3952672 FTL_0533 Francisella tularensis subsp. holarctica LVS DNA gyrase subunit A YP_513302.1 513894 D 376619 CDS YP_513303.1 89255941 3952673 516506..517663 1 NC_007880.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 517663 3952673 FTL_0534 Francisella tularensis subsp. holarctica LVS 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_513303.1 516506 D 376619 CDS YP_513304.1 89255942 3952674 517669..520047 1 NC_007880.1 outer membrane protein 520047 3952674 FTL_0535 Francisella tularensis subsp. holarctica LVS outer membrane protein YP_513304.1 517669 D 376619 CDS YP_513305.1 89255943 3952675 520183..520686 1 NC_007880.1 outer membrane protein OmpH 520686 3952675 FTL_0536 Francisella tularensis subsp. holarctica LVS outer membrane protein OmpH YP_513305.1 520183 D 376619 CDS YP_513306.1 89255944 3952676 520705..521718 1 NC_007880.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 521718 lpxD 3952676 lpxD Francisella tularensis subsp. holarctica LVS UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_513306.1 520705 D 376619 CDS YP_513307.1 89255945 3952677 521733..522224 1 NC_007880.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 522224 fabZ 3952677 fabZ Francisella tularensis subsp. holarctica LVS (3R)-hydroxymyristoyl-ACP dehydratase YP_513307.1 521733 D 376619 CDS YP_513308.1 89255946 3952678 522227..523006 1 NC_007880.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 523006 3952678 FTL_0539 Francisella tularensis subsp. holarctica LVS UDP-N-acetylglucosamine acyltransferase YP_513308.1 522227 D 376619 CDS YP_513309.1 89255947 3952679 523006..524148 1 NC_007880.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 524148 lpxB 3952679 lpxB Francisella tularensis subsp. holarctica LVS lipid-A-disaccharide synthase YP_513309.1 523006 D 376619 CDS YP_513310.1 89255948 3952680 524207..524794 1 NC_007880.1 hypothetical protein 524794 3952680 FTL_0541 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513310.1 524207 D 376619 CDS YP_513311.1 89255949 3952681 524885..525259 1 NC_007880.1 hypothetical protein 525259 3952681 FTL_0542 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513311.1 524885 D 376619 CDS YP_513312.1 89255950 3952722 complement(527080..527889) 1 NC_007880.1 hypothetical protein 527889 3952722 FTL_0544 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513312.1 527080 R 376619 CDS YP_513313.1 89255951 3952723 complement(527959..528723) 1 NC_007880.1 phosphatidylcholine synthase 528723 3952723 FTL_0545 Francisella tularensis subsp. holarctica LVS phosphatidylcholine synthase YP_513313.1 527959 R 376619 CDS YP_513314.1 89255952 3952724 complement(528771..529652) 1 NC_007880.1 geranyltranstransferase 529652 3952724 FTL_0546 Francisella tularensis subsp. holarctica LVS geranyltranstransferase YP_513314.1 528771 R 376619 CDS YP_513315.1 89255953 3952725 complement(529649..530944) 1 NC_007880.1 3-deoxy-D-manno-octulosonic-acid transferase 530944 3952725 FTL_0547 Francisella tularensis subsp. holarctica LVS 3-deoxy-D-manno-octulosonic-acid transferase YP_513315.1 529649 R 376619 CDS YP_513316.1 89255954 3952726 complement(531049..531627) 1 NC_007880.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 531627 3952726 FTL_0548 Francisella tularensis subsp. holarctica LVS putative deoxyribonucleotide triphosphate pyrophosphatase YP_513316.1 531049 R 376619 CDS YP_513317.1 89255955 3952727 531734..532558 1 NC_007880.1 pyrroline-5-carboxylate reductase 532558 3952727 FTL_0549 Francisella tularensis subsp. holarctica LVS pyrroline-5-carboxylate reductase YP_513317.1 531734 D 376619 CDS YP_513318.1 89255956 3952730 534316..535002 1 NC_007880.1 two-component response regulator 535002 3952730 FTL_0552 Francisella tularensis subsp. holarctica LVS two-component response regulator YP_513318.1 534316 D 376619 CDS YP_513319.1 89255957 3952731 535007..535870 1 NC_007880.1 signal peptidase I 535870 3952731 FTL_0553 Francisella tularensis subsp. holarctica LVS signal peptidase I YP_513319.1 535007 D 376619 CDS YP_513320.1 89255958 3952732 535877..536569 1 NC_007880.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 536569 rnc 3952732 rnc Francisella tularensis subsp. holarctica LVS ribonuclease III YP_513320.1 535877 D 376619 CDS YP_513321.1 89255959 3952733 536556..537464 1 NC_007880.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 537464 truB 3952733 truB Francisella tularensis subsp. holarctica LVS tRNA pseudouridine synthase B YP_513321.1 536556 D 376619 CDS YP_513322.1 89255960 3952734 537457..539709 1 NC_007880.1 ribonuclease R 539709 3952734 FTL_0556 Francisella tularensis subsp. holarctica LVS ribonuclease R YP_513322.1 537457 D 376619 CDS YP_513323.1 89255961 3952735 complement(539777..540415) 1 NC_007880.1 Delta 9 acyl-lipid fatty acid desaturase 540415 3952735 FTL_0557 Francisella tularensis subsp. holarctica LVS Delta 9 acyl-lipid fatty acid desaturase YP_513323.1 539777 R 376619 CDS YP_513324.1 89255962 3952736 complement(540620..541363) 1 NC_007880.1 oxidoreductase 541363 3952736 FTL_0558 Francisella tularensis subsp. holarctica LVS oxidoreductase YP_513324.1 540620 R 376619 CDS YP_513325.1 89255963 3952737 complement(541365..541907) 1 NC_007880.1 hypothetical protein 541907 3952737 FTL_0559 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513325.1 541365 R 376619 CDS YP_513326.1 89255964 3952738 complement(541904..542413) 1 NC_007880.1 hypothetical protein 542413 3952738 FTL_0560 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513326.1 541904 R 376619 CDS YP_513327.1 89255965 3952739 complement(542406..543500) 1 NC_007880.1 cyclopropane-fatty-acyl-phospholipid synthase 543500 3952739 FTL_0561 Francisella tularensis subsp. holarctica LVS cyclopropane-fatty-acyl-phospholipid synthase YP_513327.1 542406 R 376619 CDS YP_513328.1 89255966 3951813 complement(547305..547946) 1 NC_007880.1 transposase 547946 isftu2 3951813 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513328.1 547305 R 376619 CDS YP_513329.1 89255967 3951182 548287..548823 1 NC_007880.1 hypothetical protein 548823 3951182 FTL_0569 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513329.1 548287 D 376619 CDS YP_513330.1 89255968 3951183 548941..549342 1 NC_007880.1 hypothetical protein 549342 3951183 FTL_0570 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513330.1 548941 D 376619 CDS YP_513331.1 89255969 3951184 549517..550125 1 NC_007880.1 hypothetical protein 550125 3951184 FTL_0571 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513331.1 549517 D 376619 CDS YP_513332.1 89255970 3951185 550182..551612 1 NC_007880.1 hypothetical protein 551612 3951185 FTL_0572 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513332.1 550182 D 376619 CDS YP_513333.1 89255971 3951186 551623..552606 1 NC_007880.1 hypothetical protein 552606 3951186 FTL_0573 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513333.1 551623 D 376619 CDS YP_513334.1 89255972 3951187 552612..554006 1 NC_007880.1 hypothetical protein 554006 3951187 FTL_0574 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513334.1 552612 D 376619 CDS YP_513335.1 89255973 3951814 complement(554219..554860) 1 NC_007880.1 transposase 554860 isftu2 3951814 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513335.1 554219 R 376619 CDS YP_513336.1 89255974 3951188 555154..555672 1 NC_007880.1 hypothetical protein 555672 3951188 FTL_0576 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513336.1 555154 D 376619 CDS YP_513337.1 89255975 3951189 555709..555918 1 NC_007880.1 hypothetical protein 555918 3951189 FTL_0577 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513337.1 555709 D 376619 CDS YP_513338.1 89255976 3951190 556334..557182 1 NC_007880.1 catalyzes the formation of L-proline from L-ornithine; ornithine cyclodeaminase 557182 3951190 FTL_0578 Francisella tularensis subsp. holarctica LVS ornithine cyclodeaminase YP_513338.1 556334 D 376619 CDS YP_513339.1 89255977 3951191 557253..558668 1 NC_007880.1 putative nicotinate phosphoribosyltransferase 558668 3951191 FTL_0579 Francisella tularensis subsp. holarctica LVS putative nicotinate phosphoribosyltransferase YP_513339.1 557253 D 376619 CDS YP_513340.1 89255978 3951192 558753..558980 1 NC_007880.1 hypothetical protein 558980 3951192 FTL_0580 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513340.1 558753 D 376619 CDS YP_513341.1 89255979 3951193 559130..560410 1 NC_007880.1 sugar transport protein 560410 3951193 FTL_0581 Francisella tularensis subsp. holarctica LVS sugar transport protein YP_513341.1 559130 D 376619 CDS YP_513342.1 89255980 3951194 complement(560403..560891) 1 NC_007880.1 hypothetical protein 560891 3951194 FTL_0582 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513342.1 560403 R 376619 CDS YP_513343.1 89255981 3951195 complement(560953..562140) 1 NC_007880.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 562140 3951195 FTL_0583 Francisella tularensis subsp. holarctica LVS acetyl-CoA acetyltransferase YP_513343.1 560953 R 376619 CDS YP_513344.1 89255982 3951196 complement(562153..564849) 1 NC_007880.1 bifunctional 3-hydroxacyl-CoA dehydrogenase/acyl-CoA-binding protein 564849 3951196 FTL_0584 Francisella tularensis subsp. holarctica LVS bifunctional 3-hydroxacyl-CoA dehydrogenase/acyl-CoA-binding protein YP_513344.1 562153 R 376619 CDS YP_513345.1 89255983 3952780 complement(564922..567162) 1 NC_007880.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 567162 fadE 3952780 fadE Francisella tularensis subsp. holarctica LVS acyl-CoA dehydrogenase YP_513345.1 564922 R 376619 CDS YP_513346.1 89255984 3952781 complement(567200..568888) 1 NC_007880.1 long chain fatty acid CoA ligase 568888 3952781 FTL_0586 Francisella tularensis subsp. holarctica LVS long chain fatty acid CoA ligase YP_513346.1 567200 R 376619 CDS YP_513347.1 89255985 3952782 569104..569451 1 NC_007880.1 arsenate reductase 569451 3952782 FTL_0587 Francisella tularensis subsp. holarctica LVS arsenate reductase YP_513347.1 569104 D 376619 CDS YP_513348.1 89255986 3952783 569500..571716 1 NC_007880.1 isocitrate dehydrogenase 571716 3952783 FTL_0588 Francisella tularensis subsp. holarctica LVS isocitrate dehydrogenase YP_513348.1 569500 D 376619 CDS YP_513349.1 89255987 3952784 571730..572617 1 NC_007880.1 hypothetical protein 572617 3952784 FTL_0589 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513349.1 571730 D 376619 CDS YP_513350.1 89255988 3952785 572637..576971 1 NC_007880.1 ATp-dependent helicase 576971 3952785 FTL_0590 Francisella tularensis subsp. holarctica LVS ATp-dependent helicase YP_513350.1 572637 D 376619 CDS YP_513351.1 89255989 3951815 577532..578185 1 NC_007880.1 transposase 578185 isftu2 3951815 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513351.1 577532 D 376619 CDS YP_513352.1 89255990 3952786 578226..579962 1 NC_007880.1 dTDP-glucose 4,6-dehydratase 579962 3952786 FTL_0592 Francisella tularensis subsp. holarctica LVS dTDP-glucose 4,6-dehydratase YP_513352.1 578226 D 376619 CDS YP_513353.1 89255991 3952787 579955..580587 1 NC_007880.1 galactosyl transferase 580587 3952787 FTL_0593 Francisella tularensis subsp. holarctica LVS galactosyl transferase YP_513353.1 579955 D 376619 CDS YP_513354.1 89255992 3952788 580589..581380 1 NC_007880.1 UDP-glucose 4-epimerase 581380 3952788 FTL_0594 Francisella tularensis subsp. holarctica LVS UDP-glucose 4-epimerase YP_513354.1 580589 D 376619 CDS YP_513355.1 89255993 3952789 581370..582461 1 NC_007880.1 galacturonosyl transferase 582461 3952789 FTL_0595 Francisella tularensis subsp. holarctica LVS galacturonosyl transferase YP_513355.1 581370 D 376619 CDS YP_513356.1 89255994 3952790 582479..583789 1 NC_007880.1 UDP-glucose/GDP-mannose dehydrogenase 583789 3952790 FTL_0596 Francisella tularensis subsp. holarctica LVS UDP-glucose/GDP-mannose dehydrogenase YP_513356.1 582479 D 376619 CDS YP_513357.1 89255995 3952791 583789..584760 1 NC_007880.1 NAD dependent epimerase 584760 3952791 FTL_0597 Francisella tularensis subsp. holarctica LVS NAD dependent epimerase YP_513357.1 583789 D 376619 CDS YP_513358.1 89255996 3952792 584777..586006 1 NC_007880.1 membrane protein/O-antigen protein 586006 3952792 FTL_0598 Francisella tularensis subsp. holarctica LVS membrane protein/O-antigen protein YP_513358.1 584777 D 376619 CDS YP_513359.1 89255997 3952793 586003..587103 1 NC_007880.1 glycosyl transferase family protein 587103 3952793 FTL_0599 Francisella tularensis subsp. holarctica LVS glycosyl transferase family protein YP_513359.1 586003 D 376619 CDS YP_513360.1 89255998 3952794 587103..588989 1 NC_007880.1 asparagine synthase 588989 3952794 FTL_0600 Francisella tularensis subsp. holarctica LVS asparagine synthase YP_513360.1 587103 D 376619 CDS YP_513361.1 89255999 3952795 588982..590064 1 NC_007880.1 sugar transamine/perosamine synthetase 590064 3952795 FTL_0601 Francisella tularensis subsp. holarctica LVS sugar transamine/perosamine synthetase YP_513361.1 588982 D 376619 CDS YP_513362.1 89256000 3952796 590061..590786 1 NC_007880.1 hypothetical protein 590786 3952796 FTL_0602 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513362.1 590061 D 376619 CDS YP_513363.1 89256001 3952797 590791..592278 1 NC_007880.1 O-antigen flippase 592278 3952797 FTL_0603 Francisella tularensis subsp. holarctica LVS O-antigen flippase YP_513363.1 590791 D 376619 CDS YP_513364.1 89256002 3952798 592271..593131 1 NC_007880.1 glycosyltransferase 593131 3952798 FTL_0604 Francisella tularensis subsp. holarctica LVS glycosyltransferase YP_513364.1 592271 D 376619 CDS YP_513365.1 89256003 3951333 593156..594040 1 NC_007880.1 glucose-1-phosphate thymidylyltransferase 594040 3951333 FTL_0605 Francisella tularensis subsp. holarctica LVS glucose-1-phosphate thymidylyltransferase YP_513365.1 593156 D 376619 CDS YP_513366.1 89256004 3951334 594587..595603 1 NC_007880.1 dTDP-D-glucose 4,6-dehydratase 595603 3951334 FTL_0606 Francisella tularensis subsp. holarctica LVS dTDP-D-glucose 4,6-dehydratase YP_513366.1 594587 D 376619 CDS YP_513367.1 89256005 3952468 join(595748..596074,596074..596628) 1 NC_007880.1 transposase 596628 isftu1 3952468 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513367.1 595748 D 376619 CDS YP_513368.1 89256006 3951335 596881..598287 1 NC_007880.1 mannose-1-phosphate guanyltransferase 598287 3951335 FTL_0608 Francisella tularensis subsp. holarctica LVS mannose-1-phosphate guanyltransferase YP_513368.1 596881 D 376619 CDS YP_513369.1 89256007 3951336 598318..599802 1 NC_007880.1 phosphomannomutase 599802 3951336 FTL_0609 Francisella tularensis subsp. holarctica LVS phosphomannomutase YP_513369.1 598318 D 376619 CDS YP_513370.1 89256008 3951337 complement(600895..602157) 1 NC_007880.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 602157 rho 3951337 rho Francisella tularensis subsp. holarctica LVS transcription termination factor Rho YP_513370.1 600895 R 376619 CDS YP_513371.1 89256009 3951338 complement(602200..602523) 1 NC_007880.1 thioredoxin 602523 3951338 FTL_0611 Francisella tularensis subsp. holarctica LVS thioredoxin YP_513371.1 602200 R 376619 CDS YP_513372.1 89256010 3951339 602721..603647 1 NC_007880.1 exopolyphosphatase 603647 3951339 FTL_0612 Francisella tularensis subsp. holarctica LVS exopolyphosphatase YP_513372.1 602721 D 376619 CDS YP_513373.1 89256011 3951816 complement(603576..604262) 1 NC_007880.1 transposase 604262 isftu2 3951816 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513373.1 603576 R 376619 CDS YP_513374.1 89256012 3951341 605084..605986 1 NC_007880.1 recombination factor protein RarA 605986 3951341 FTL_0615 Francisella tularensis subsp. holarctica LVS recombination factor protein RarA YP_513374.1 605084 D 376619 CDS YP_513375.1 89256013 3951342 606074..607027 1 NC_007880.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 607027 3951342 FTL_0616 Francisella tularensis subsp. holarctica LVS DNA-directed RNA polymerase subunit alpha YP_513375.1 606074 D 376619 CDS YP_513376.1 89256014 3951343 complement(607646..608086) 1 NC_007880.1 hypothetical protein 608086 3951343 FTL_0617 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513376.1 607646 R 376619 CDS YP_513377.1 89256015 3951346 609798..610565 1 NC_007880.1 deoxyribonuclease 610565 3951346 FTL_0620 Francisella tularensis subsp. holarctica LVS deoxyribonuclease YP_513377.1 609798 D 376619 CDS YP_513378.1 89256016 3951817 complement(611800..612432) 1 NC_007880.1 transposase 612432 isftu2 3951817 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513378.1 611800 R 376619 CDS YP_513379.1 89256017 3951348 612750..613673 1 NC_007880.1 ABC transporter ATP-binding protein 613673 3951348 FTL_0623 Francisella tularensis subsp. holarctica LVS ABC transporter ATP-binding protein YP_513379.1 612750 D 376619 CDS YP_513380.1 89256018 3951349 613682..614461 1 NC_007880.1 ABC transporter membrane protein 614461 3951349 FTL_0624 Francisella tularensis subsp. holarctica LVS ABC transporter membrane protein YP_513380.1 613682 D 376619 CDS YP_513381.1 89256019 3951350 complement(614465..615409) 1 NC_007880.1 glycosyl transferase family protein 615409 3951350 FTL_0625 Francisella tularensis subsp. holarctica LVS glycosyl transferase family protein YP_513381.1 614465 R 376619 CDS YP_513382.1 89256020 3951351 615600..616490 1 NC_007880.1 inorganic phosphate/ATP-NAD kinase 616490 3951351 FTL_0626 Francisella tularensis subsp. holarctica LVS inorganic phosphate/ATP-NAD kinase YP_513382.1 615600 D 376619 CDS YP_513383.1 89256021 3951352 complement(616487..617122) 1 NC_007880.1 threonine efflux protein 617122 3951352 FTL_0627 Francisella tularensis subsp. holarctica LVS threonine efflux protein YP_513383.1 616487 R 376619 CDS YP_513384.1 89256022 3952469 complement(join(619191..619745,619745..620071)) 1 NC_007880.1 transposase 620071 isftu1 3952469 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513384.1 619191 R 376619 CDS YP_513385.1 89256023 3951549 620245..620544 1 NC_007880.1 ArsR family transcriptional regulator 620544 3951549 FTL_0632 Francisella tularensis subsp. holarctica LVS ArsR family transcriptional regulator YP_513385.1 620245 D 376619 CDS YP_513386.1 89256024 3951550 620610..621128 1 NC_007880.1 hypothetical protein 621128 3951550 FTL_0633 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513386.1 620610 D 376619 CDS YP_513387.1 89256025 3951551 621153..621278 1 NC_007880.1 NADH oxidase 621278 3951551 FTL_0634 Francisella tularensis subsp. holarctica LVS NADH oxidase YP_513387.1 621153 D 376619 CDS YP_513388.1 89256026 3951552 621339..621959 1 NC_007880.1 FAD-dependent pyridine nucleotide-disulfide oxidoreductase 621959 3951552 FTL_0635 Francisella tularensis subsp. holarctica LVS FAD-dependent pyridine nucleotide-disulfide oxidoreductase YP_513388.1 621339 D 376619 CDS YP_513389.1 89256027 3951553 622009..622845 1 NC_007880.1 NADH oxidase 622845 3951553 FTL_0636 Francisella tularensis subsp. holarctica LVS NADH oxidase YP_513389.1 622009 D 376619 CDS YP_513390.1 89256028 3951554 622890..623576 1 NC_007880.1 hypothetical protein 623576 3951554 FTL_0637 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513390.1 622890 D 376619 CDS YP_513391.1 89256029 3951555 623578..624327 1 NC_007880.1 hypothetical protein 624327 3951555 FTL_0638 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513391.1 623578 D 376619 CDS YP_513392.1 89256030 3951556 complement(624320..624928) 1 NC_007880.1 oxidoreductase 624928 3951556 FTL_0639 Francisella tularensis subsp. holarctica LVS oxidoreductase YP_513392.1 624320 R 376619 CDS YP_513393.1 89256031 3951557 complement(624980..625429) 1 NC_007880.1 hypothetical protein 625429 3951557 FTL_0640 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513393.1 624980 R 376619 CDS YP_513394.1 89256032 3951558 complement(625660..626115) 1 NC_007880.1 hypothetical protein 626115 3951558 FTL_0641 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513394.1 625660 R 376619 CDS YP_513395.1 89256033 3951559 complement(626176..626673) 1 NC_007880.1 lipoprotein 626673 3951559 FTL_0642 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513395.1 626176 R 376619 CDS YP_513396.1 89256034 3951560 626753..627178 1 NC_007880.1 N utilisation substance protein B 627178 3951560 FTL_0643 Francisella tularensis subsp. holarctica LVS N utilisation substance protein B YP_513396.1 626753 D 376619 CDS YP_513397.1 89256035 3951561 complement(627162..627932) 1 NC_007880.1 carbon-nitrogen hydrolase 627932 3951561 FTL_0644 Francisella tularensis subsp. holarctica LVS carbon-nitrogen hydrolase YP_513397.1 627162 R 376619 CDS YP_513398.1 89256036 3951562 628101..628514 1 NC_007880.1 lipoprotein 628514 3951562 FTL_0645 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513398.1 628101 D 376619 CDS YP_513399.1 89256037 3951563 complement(628660..629469) 1 NC_007880.1 hypothetical protein 629469 3951563 FTL_0646 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513399.1 628660 R 376619 CDS YP_513400.1 89256038 3951564 complement(629577..630059) 1 NC_007880.1 hypothetical protein 630059 3951564 FTL_0647 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513400.1 629577 R 376619 CDS YP_513401.1 89256039 3951487 complement(630059..630688) 1 NC_007880.1 aminotransferase 630688 3951487 FTL_0648 Francisella tularensis subsp. holarctica LVS aminotransferase YP_513401.1 630059 R 376619 CDS YP_513402.1 89256040 3951488 complement(630712..631191) 1 NC_007880.1 aspartate/tyrosine/aromatic aminotransferase family protein 631191 3951488 FTL_0649 Francisella tularensis subsp. holarctica LVS aspartate/tyrosine/aromatic aminotransferase family protein YP_513402.1 630712 R 376619 CDS YP_513403.1 89256041 3951489 complement(631337..633034) 1 NC_007880.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 633034 3951489 FTL_0650 Francisella tularensis subsp. holarctica LVS prolyl-tRNA synthetase YP_513403.1 631337 R 376619 CDS YP_513404.1 89256042 3951490 complement(633888..634187) 1 NC_007880.1 transposase 634187 3951490 FTL_0651 Francisella tularensis subsp. holarctica LVS transposase YP_513404.1 633888 R 376619 CDS YP_513405.1 89256043 3951491 complement(635603..636139) 1 NC_007880.1 hypothetical protein 636139 3951491 FTL_0652 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513405.1 635603 R 376619 CDS YP_513406.1 89256044 3951492 636846..637262 1 NC_007880.1 hypothetical protein 637262 3951492 FTL_0653 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513406.1 636846 D 376619 CDS YP_513407.1 89256045 3951493 637263..638012 1 NC_007880.1 uroporphyrinogen III synthase 638012 3951493 FTL_0654 Francisella tularensis subsp. holarctica LVS uroporphyrinogen III synthase YP_513407.1 637263 D 376619 CDS YP_513408.1 89256046 3951494 637978..639063 1 NC_007880.1 hypothetical protein 639063 3951494 FTL_0655 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513408.1 637978 D 376619 CDS YP_513409.1 89256047 3951495 639060..640217 1 NC_007880.1 hypothetical protein 640217 3951495 FTL_0656 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513409.1 639060 D 376619 CDS YP_513410.1 89256048 3951496 640231..640989 1 NC_007880.1 hydroxyacylglutathione hydrolase 640989 3951496 FTL_0657 Francisella tularensis subsp. holarctica LVS hydroxyacylglutathione hydrolase YP_513410.1 640231 D 376619 CDS YP_513411.1 89256049 3951497 complement(641067..641774) 1 NC_007880.1 cell division protein 641774 3951497 FTL_0659 Francisella tularensis subsp. holarctica LVS cell division protein YP_513411.1 641067 R 376619 CDS YP_513412.1 89256050 3951498 641883..642107 1 NC_007880.1 ferrous iron transport protein A 642107 3951498 FTL_0660 Francisella tularensis subsp. holarctica LVS ferrous iron transport protein A YP_513412.1 641883 D 376619 CDS YP_513413.1 89256051 3951499 642124..643758 1 NC_007880.1 hypothetical protein 643758 3951499 FTL_0661 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513413.1 642124 D 376619 CDS YP_513414.1 89256052 3951500 complement(644330..644983) 1 NC_007880.1 prophage repressor protein 644983 3951500 FTL_0662 Francisella tularensis subsp. holarctica LVS prophage repressor protein YP_513414.1 644330 R 376619 CDS YP_513415.1 89256053 3951501 645152..645520 1 NC_007880.1 hypothetical protein 645520 3951501 FTL_0663 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513415.1 645152 D 376619 CDS YP_513416.1 89256054 3951502 complement(645551..646423) 1 NC_007880.1 hypothetical protein 646423 3951502 FTL_0664 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513416.1 645551 R 376619 CDS YP_513417.1 89256055 3951503 646600..648186 1 NC_007880.1 hypothetical protein 648186 3951503 FTL_0665 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513417.1 646600 D 376619 CDS YP_513418.1 89256056 3951504 648263..651502 1 NC_007880.1 exodeoxyribonuclease V subunit gamma 651502 3951504 FTL_0666 Francisella tularensis subsp. holarctica LVS exodeoxyribonuclease V subunit gamma YP_513418.1 648263 D 376619 CDS YP_513419.1 89256057 3951505 651486..652016 1 NC_007880.1 hypothetical protein 652016 3951505 FTL_0667 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513419.1 651486 D 376619 CDS YP_513420.1 89256058 3951506 652159..653589 1 NC_007880.1 ATP-dependent DNA helicase 653589 3951506 FTL_0668 Francisella tularensis subsp. holarctica LVS ATP-dependent DNA helicase YP_513420.1 652159 D 376619 CDS YP_513421.1 89256059 3952540 653661..657314 1 NC_007880.1 exodeoxyribonuclease V subunit beta 657314 3952540 FTL_0669 Francisella tularensis subsp. holarctica LVS exodeoxyribonuclease V subunit beta YP_513421.1 653661 D 376619 CDS YP_513422.1 89256060 3952541 657307..659148 1 NC_007880.1 exodeoxyribonuclease V subunit alpha 659148 3952541 FTL_0670 Francisella tularensis subsp. holarctica LVS exodeoxyribonuclease V subunit alpha YP_513422.1 657307 D 376619 CDS YP_513423.1 89256061 3952542 complement(659157..659927) 1 NC_007880.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 659927 3952542 FTL_0671 Francisella tularensis subsp. holarctica LVS pantothenate kinase YP_513423.1 659157 R 376619 CDS YP_513424.1 89256062 3952543 complement(659991..660266) 1 NC_007880.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 660266 3952543 FTL_0672 Francisella tularensis subsp. holarctica LVS aspartate alpha-decarboxylase YP_513424.1 659991 R 376619 CDS YP_513425.1 89256063 3952544 complement(660260..661045) 1 NC_007880.1 pantoate-beta-alanine ligase 661045 3952544 FTL_0673 Francisella tularensis subsp. holarctica LVS pantoate-beta-alanine ligase YP_513425.1 660260 R 376619 CDS YP_513426.1 89256064 3952545 complement(661032..661883) 1 NC_007880.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 661883 panB 3952545 panB Francisella tularensis subsp. holarctica LVS 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_513426.1 661032 R 376619 CDS YP_513427.1 89256065 3952546 complement(661831..662544) 1 NC_007880.1 hypothetical protein 662544 3952546 FTL_0675 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513427.1 661831 R 376619 CDS YP_513428.1 89256066 3952547 662852..664888 1 NC_007880.1 DNA ligase 664888 3952547 FTL_0676 Francisella tularensis subsp. holarctica LVS DNA ligase YP_513428.1 662852 D 376619 CDS YP_513429.1 89256067 3952548 664885..665262 1 NC_007880.1 hypothetical protein 665262 3952548 FTL_0677 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513429.1 664885 D 376619 CDS YP_513430.1 89256068 3952470 complement(join(665240..665794,665794..666120)) 1 NC_007880.1 transposase 666120 isftu1 3952470 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513430.1 665240 R 376619 CDS YP_513431.1 89256069 3952549 complement(666344..667150) 1 NC_007880.1 polyamine transporter, subunit I, ABC transporter, membrane protein 667150 3952549 FTL_0679 Francisella tularensis subsp. holarctica LVS polyamine transporter, subunit I, ABC transporter, membrane protein YP_513431.1 666344 R 376619 CDS YP_513432.1 89256070 3952550 complement(667164..668045) 1 NC_007880.1 polyamine transporter, subunit H, ABC transporter, membrane protein 668045 3952550 FTL_0680 Francisella tularensis subsp. holarctica LVS polyamine transporter, subunit H, ABC transporter, membrane protein YP_513432.1 667164 R 376619 CDS YP_513433.1 89256071 3952551 complement(668045..669166) 1 NC_007880.1 polyamine transporter, ABC transporter,ATP-binding protein 669166 3952551 FTL_0681 Francisella tularensis subsp. holarctica LVS polyamine transporter, ABC transporter,ATP-binding protein YP_513433.1 668045 R 376619 CDS YP_513434.1 89256072 3952471 complement(join(669449..670003,670003..670329)) 1 NC_007880.1 transposase 670329 isftu1 3952471 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513434.1 669449 R 376619 CDS YP_513435.1 89256073 3952553 complement(671099..671521) 1 NC_007880.1 hypothetical protein 671521 3952553 FTL_0684 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513435.1 671099 R 376619 CDS YP_513436.1 89256074 3952554 complement(671625..672374) 1 NC_007880.1 NH(3)-dependent NAD(+) synthetase 672374 3952554 FTL_0685 Francisella tularensis subsp. holarctica LVS NH(3)-dependent NAD(+) synthetase YP_513436.1 671625 R 376619 CDS YP_513437.1 89256075 3952555 complement(672503..673975) 1 NC_007880.1 outer membrane efflux protein 673975 3952555 FTL_0686 Francisella tularensis subsp. holarctica LVS outer membrane efflux protein YP_513437.1 672503 R 376619 CDS YP_513438.1 89256076 3952556 complement(673985..675007) 1 NC_007880.1 HlyD family secretion protein 675007 3952556 FTL_0687 Francisella tularensis subsp. holarctica LVS HlyD family secretion protein YP_513438.1 673985 R 376619 CDS YP_513439.1 89256077 3952557 complement(675029..676558) 1 NC_007880.1 major facilitator transporter 676558 3952557 FTL_0688 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_513439.1 675029 R 376619 CDS YP_513440.1 89256078 3952558 676723..677550 1 NC_007880.1 transcriptional regulator araC family protein 677550 3952558 FTL_0689 Francisella tularensis subsp. holarctica LVS transcriptional regulator araC family protein YP_513440.1 676723 D 376619 CDS YP_513441.1 89256079 3951059 complement(677538..679229) 1 NC_007880.1 Acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase) 679229 3951059 FTL_0690 Francisella tularensis subsp. holarctica LVS Acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase) YP_513441.1 677538 R 376619 CDS YP_513442.1 89256080 3951060 complement(679337..680818) 1 NC_007880.1 proton-dependent oligopeptide transport (POT) family protein 680818 3951060 FTL_0691 Francisella tularensis subsp. holarctica LVS proton-dependent oligopeptide transport (POT) family protein YP_513442.1 679337 R 376619 CDS YP_513443.1 89256081 3951061 complement(681054..681782) 1 NC_007880.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 681782 3951061 FTL_0692 Francisella tularensis subsp. holarctica LVS 16S ribosomal RNA methyltransferase RsmE YP_513443.1 681054 R 376619 CDS YP_513444.1 89256082 3951062 681853..682539 1 NC_007880.1 hypothetical protein 682539 3951062 FTL_0693 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513444.1 681853 D 376619 CDS YP_513445.1 89256083 3951063 complement(682529..683227) 1 NC_007880.1 hypothetical protein 683227 3951063 FTL_0694 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513445.1 682529 R 376619 CDS YP_513446.1 89256084 3951064 complement(683232..683957) 1 NC_007880.1 cell entry (mce) related family protein 683957 3951064 FTL_0695 Francisella tularensis subsp. holarctica LVS cell entry (mce) related family protein YP_513446.1 683232 R 376619 CDS YP_513447.1 89256085 3951065 complement(683967..684728) 1 NC_007880.1 ABC transporter ATP-binding protein 684728 3951065 FTL_0696 Francisella tularensis subsp. holarctica LVS ABC transporter ATP-binding protein YP_513447.1 683967 R 376619 CDS YP_513448.1 89256086 3951066 complement(684743..685843) 1 NC_007880.1 ABC transporter membrane protein 685843 3951066 FTL_0697 Francisella tularensis subsp. holarctica LVS ABC transporter membrane protein YP_513448.1 684743 R 376619 CDS YP_513449.1 89256087 3951067 complement(685918..686754) 1 NC_007880.1 hypothetical protein 686754 3951067 FTL_0698 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513449.1 685918 R 376619 CDS YP_513450.1 89256088 3951068 complement(686708..687706) 1 NC_007880.1 ribosomal large subunit pseudouridine synthase D 687706 3951068 FTL_0699 Francisella tularensis subsp. holarctica LVS ribosomal large subunit pseudouridine synthase D YP_513450.1 686708 R 376619 CDS YP_513451.1 89256089 3951069 687794..688618 1 NC_007880.1 lipoprotein 688618 3951069 FTL_0700 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513451.1 687794 D 376619 CDS YP_513452.1 89256090 3951070 688726..690495 1 NC_007880.1 FAD binding family protein 690495 3951070 FTL_0701 Francisella tularensis subsp. holarctica LVS FAD binding family protein YP_513452.1 688726 D 376619 CDS YP_513453.1 89256091 3951071 complement(690560..692017) 1 NC_007880.1 hypothetical protein 692017 3951071 FTL_0702 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513453.1 690560 R 376619 CDS YP_513454.1 89256092 3951072 complement(692295..693548) 1 NC_007880.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 693548 glyA 3951072 glyA Francisella tularensis subsp. holarctica LVS serine hydroxymethyltransferase YP_513454.1 692295 R 376619 CDS YP_513455.1 89256093 3951073 693652..694200 1 NC_007880.1 hypothetical protein 694200 3951073 FTL_0704 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513455.1 693652 D 376619 CDS YP_513456.1 89256094 3951074 complement(694215..695486) 1 NC_007880.1 hypothetical protein 695486 3951074 FTL_0705 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513456.1 694215 R 376619 CDS YP_513457.1 89256095 3951075 695694..697025 1 NC_007880.1 hypothetical protein 697025 3951075 FTL_0706 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513457.1 695694 D 376619 CDS YP_513458.1 89256096 3951076 complement(697051..697941) 1 NC_007880.1 glycosyl transferase family protein 697941 3951076 FTL_0707 Francisella tularensis subsp. holarctica LVS glycosyl transferase family protein YP_513458.1 697051 R 376619 CDS YP_513459.1 89256097 3951077 complement(697949..699037) 1 NC_007880.1 hypothetical protein 699037 3951077 FTL_0708 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513459.1 697949 R 376619 CDS YP_513460.1 89256098 3951078 699207..700271 1 NC_007880.1 glycosyl transferases group 1 family protein 700271 3951078 FTL_0709 Francisella tularensis subsp. holarctica LVS glycosyl transferases group 1 family protein YP_513460.1 699207 D 376619 CDS YP_513461.1 89256099 3951604 complement(700348..701301) 1 NC_007880.1 choloylglycine hydrolase family protein 701301 3951604 FTL_0710 Francisella tularensis subsp. holarctica LVS choloylglycine hydrolase family protein YP_513461.1 700348 R 376619 CDS YP_513462.1 89256100 3951605 701797..702390 1 NC_007880.1 proton-dependent oligopeptide transport (POT) family protein 702390 3951605 FTL_0711 Francisella tularensis subsp. holarctica LVS proton-dependent oligopeptide transport (POT) family protein YP_513462.1 701797 D 376619 CDS YP_513463.1 89256101 3951606 702481..702990 1 NC_007880.1 hypothetical protein 702990 3951606 FTL_0712 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513463.1 702481 D 376619 CDS YP_513464.1 89256102 3951607 complement(702998..704194) 1 NC_007880.1 PP-loop family protein 704194 3951607 FTL_0713 Francisella tularensis subsp. holarctica LVS PP-loop family protein YP_513464.1 702998 R 376619 CDS YP_513465.1 89256103 3951608 complement(704195..705430) 1 NC_007880.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 705430 3951608 FTL_0714 Francisella tularensis subsp. holarctica LVS D-3-phosphoglycerate dehydrogenase YP_513465.1 704195 R 376619 CDS YP_513466.1 89256104 3951609 complement(705442..706266) 1 NC_007880.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 706266 thyA 3951609 thyA Francisella tularensis subsp. holarctica LVS thymidylate synthase YP_513466.1 705442 R 376619 CDS YP_513467.1 89256105 3951610 complement(706251..707057) 1 NC_007880.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 707057 3951610 FTL_0716 Francisella tularensis subsp. holarctica LVS prolipoprotein diacylglyceryl transferase YP_513467.1 706251 R 376619 CDS YP_513468.1 89256106 3951611 complement(707072..709603) 1 NC_007880.1 ribonuclease E 709603 3951611 FTL_0717 Francisella tularensis subsp. holarctica LVS ribonuclease E YP_513468.1 707072 R 376619 CDS YP_513469.1 89256107 3951612 709853..711028 1 NC_007880.1 cysteine desulfarase 711028 3951612 FTL_0718 Francisella tularensis subsp. holarctica LVS cysteine desulfarase YP_513469.1 709853 D 376619 CDS YP_513470.1 89256108 3951613 711021..711350 1 NC_007880.1 hypothetical protein 711350 3951613 FTL_0719 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513470.1 711021 D 376619 CDS YP_513471.1 89256109 3951614 711334..712032 1 NC_007880.1 DNA repair protein recO 712032 3951614 FTL_0720 Francisella tularensis subsp. holarctica LVS DNA repair protein recO YP_513471.1 711334 D 376619 CDS YP_513472.1 89256110 3951615 complement(712108..712755) 1 NC_007880.1 DedA family protein 712755 3951615 FTL_0721 Francisella tularensis subsp. holarctica LVS DedA family protein YP_513472.1 712108 R 376619 CDS YP_513473.1 89256111 3951616 complement(712811..713437) 1 NC_007880.1 DedA family protein 713437 3951616 FTL_0722 Francisella tularensis subsp. holarctica LVS DedA family protein YP_513473.1 712811 R 376619 CDS YP_513474.1 89256112 3951617 complement(713444..713710) 1 NC_007880.1 hypothetical protein 713710 3951617 FTL_0723 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513474.1 713444 R 376619 CDS YP_513475.1 89256113 3951618 complement(713713..714261) 1 NC_007880.1 5-formyltetrahydrofolate cyclo-ligase 714261 3951618 FTL_0724 Francisella tularensis subsp. holarctica LVS 5-formyltetrahydrofolate cyclo-ligase YP_513475.1 713713 R 376619 CDS YP_513476.1 89256114 3951619 714701..715237 1 NC_007880.1 hypothetical protein 715237 3951619 FTL_0725 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513476.1 714701 D 376619 CDS YP_513477.1 89256115 3951620 715246..716457 1 NC_007880.1 2-octaprenyl-6-methoxyphenyl hydroxylase 716457 3951620 FTL_0726 Francisella tularensis subsp. holarctica LVS 2-octaprenyl-6-methoxyphenyl hydroxylase YP_513477.1 715246 D 376619 CDS YP_513478.1 89256116 3951621 716447..717682 1 NC_007880.1 monooxygenase family protein 717682 3951621 FTL_0727 Francisella tularensis subsp. holarctica LVS monooxygenase family protein YP_513478.1 716447 D 376619 CDS YP_513479.1 89256117 3951622 717704..718165 1 NC_007880.1 hypothetical protein 718165 3951622 FTL_0728 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513479.1 717704 D 376619 CDS YP_513480.1 89256118 3952228 718191..719207 1 NC_007880.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 719207 queA 3952228 queA Francisella tularensis subsp. holarctica LVS S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_513480.1 718191 D 376619 CDS YP_513481.1 89256119 3952229 719842..720633 1 NC_007880.1 haloacid dehalogenase-like hydrolase family protein 720633 3952229 FTL_0730 Francisella tularensis subsp. holarctica LVS haloacid dehalogenase-like hydrolase family protein YP_513481.1 719842 D 376619 CDS YP_513482.1 89256120 3952230 complement(720887..721600) 1 NC_007880.1 YhhQ family protein 721600 3952230 FTL_0731 Francisella tularensis subsp. holarctica LVS YhhQ family protein YP_513482.1 720887 R 376619 CDS YP_513483.1 89256121 3952231 721716..722099 1 NC_007880.1 lactoylglutathione lyase 722099 3952231 FTL_0732 Francisella tularensis subsp. holarctica LVS lactoylglutathione lyase YP_513483.1 721716 D 376619 CDS YP_513484.1 89256122 3952472 join(722553..722879,722879..723433) 1 NC_007880.1 transposase 723433 isftu1 3952472 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513484.1 722553 D 376619 CDS YP_513485.1 89256123 3952234 complement(725411..726085) 1 NC_007880.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 726085 3952234 FTL_0736 Francisella tularensis subsp. holarctica LVS ribose-5-phosphate isomerase A YP_513485.1 725411 R 376619 CDS YP_513486.1 89256124 3952235 complement(726087..727457) 1 NC_007880.1 hypothetical protein 727457 3952235 FTL_0737 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513486.1 726087 R 376619 CDS YP_513487.1 89256125 3952236 complement(727471..727863) 1 NC_007880.1 hypothetical protein 727863 3952236 FTL_0738 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513487.1 727471 R 376619 CDS YP_513488.1 89256126 3952237 complement(727875..729758) 1 NC_007880.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 729758 3952237 FTL_0739 Francisella tularensis subsp. holarctica LVS tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_513488.1 727875 R 376619 CDS YP_513489.1 89256127 3952238 729901..730983 1 NC_007880.1 hypothetical protein 730983 3952238 FTL_0740 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513489.1 729901 D 376619 CDS YP_513490.1 89256128 3952239 730970..731875 1 NC_007880.1 hypothetical protein 731875 3952239 FTL_0741 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513490.1 730970 D 376619 CDS YP_513491.1 89256129 3952240 complement(731886..732344) 1 NC_007880.1 LysR family transcriptional regulator 732344 3952240 FTL_0742 Francisella tularensis subsp. holarctica LVS LysR family transcriptional regulator YP_513491.1 731886 R 376619 CDS YP_513492.1 89256130 3952241 732901..733623 1 NC_007880.1 oxidoreductase, short-chain dehydrogenase family protein 733623 3952241 FTL_0743 Francisella tularensis subsp. holarctica LVS oxidoreductase, short-chain dehydrogenase family protein YP_513492.1 732901 D 376619 CDS YP_513493.1 89256131 3952242 733757..735205 1 NC_007880.1 exodeoxyribonuclease I 735205 3952242 FTL_0744 Francisella tularensis subsp. holarctica LVS exodeoxyribonuclease I YP_513493.1 733757 D 376619 CDS YP_513494.1 89256132 3952243 735207..737213 1 NC_007880.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 737213 3952243 FTL_0745 Francisella tularensis subsp. holarctica LVS excinuclease ABC subunit B YP_513494.1 735207 D 376619 CDS YP_513495.1 89256133 3952244 737250..738047 1 NC_007880.1 hypothetical protein 738047 3952244 FTL_0746 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513495.1 737250 D 376619 CDS YP_513496.1 89256134 3952245 738047..738844 1 NC_007880.1 glutamate racemase 738844 3952245 FTL_0747 Francisella tularensis subsp. holarctica LVS glutamate racemase YP_513496.1 738047 D 376619 CDS YP_513497.1 89256135 3952246 738935..740212 1 NC_007880.1 major facilitator transporter 740212 3952246 FTL_0748 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_513497.1 738935 D 376619 CDS YP_513498.1 89256136 3951818 740493..741116 1 NC_007880.1 transposase 741116 isftu2 3951818 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513498.1 740493 D 376619 CDS YP_513499.1 89256137 3951118 742742..743668 1 NC_007880.1 lipoprotein 743668 3951118 FTL_0751 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513499.1 742742 D 376619 CDS YP_513500.1 89256138 3951119 743685..745436 1 NC_007880.1 hypothetical protein 745436 3951119 FTL_0752 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513500.1 743685 D 376619 CDS YP_513501.1 89256139 3951120 complement(745486..746424) 1 NC_007880.1 aminoacylase 746424 3951120 FTL_0753 Francisella tularensis subsp. holarctica LVS aminoacylase YP_513501.1 745486 R 376619 CDS YP_513502.1 89256140 3951121 746799..748184 1 NC_007880.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 748184 xseA 3951121 xseA Francisella tularensis subsp. holarctica LVS exodeoxyribonuclease VII large subunit YP_513502.1 746799 D 376619 CDS YP_513503.1 89256141 3951122 748168..748368 1 NC_007880.1 hypothetical protein 748368 3951122 FTL_0755 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513503.1 748168 D 376619 CDS YP_513504.1 89256142 3951126 complement(749981..750592) 1 NC_007880.1 hypothetical protein 750592 3951126 FTL_0759 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513504.1 749981 R 376619 CDS YP_513505.1 89256143 3951127 complement(750859..751614) 1 NC_007880.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 751614 3951127 FTL_0760 Francisella tularensis subsp. holarctica LVS C32 tRNA thiolase YP_513505.1 750859 R 376619 CDS YP_513506.1 89256144 3951128 complement(751615..752088) 1 NC_007880.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 752088 smpB 3951128 smpB Francisella tularensis subsp. holarctica LVS SsrA-binding protein YP_513506.1 751615 R 376619 CDS YP_513507.1 89256145 3951129 752163..752594 1 NC_007880.1 hypothetical protein 752594 3951129 FTL_0762 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513507.1 752163 D 376619 CDS YP_513508.1 89256146 3951130 752594..752899 1 NC_007880.1 hypothetical protein 752899 3951130 FTL_0763 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513508.1 752594 D 376619 CDS YP_513509.1 89256147 3951131 752941..754146 1 NC_007880.1 lipoprotein 754146 3951131 FTL_0764 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513509.1 752941 D 376619 CDS YP_513510.1 89256148 3951132 754223..755143 1 NC_007880.1 VacJ lipoprotein 755143 3951132 FTL_0765 Francisella tularensis subsp. holarctica LVS VacJ lipoprotein YP_513510.1 754223 D 376619 CDS YP_513511.1 89256149 3951133 755198..757003 1 NC_007880.1 gamma-glutamyltranspeptidase 757003 3951133 FTL_0766 Francisella tularensis subsp. holarctica LVS gamma-glutamyltranspeptidase YP_513511.1 755198 D 376619 CDS YP_513512.1 89256150 3951134 complement(757019..757774) 1 NC_007880.1 hypothetical protein 757774 3951134 FTL_0767 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513512.1 757019 R 376619 CDS YP_513513.1 89256151 3951135 complement(757946..759763) 1 NC_007880.1 GTP binding translational elongation factor Tu and G family protein 759763 3951135 FTL_0768 Francisella tularensis subsp. holarctica LVS GTP binding translational elongation factor Tu and G family protein YP_513513.1 757946 R 376619 CDS YP_513514.1 89256152 3951136 760489..761736 1 NC_007880.1 hypothetical protein 761736 3951136 FTL_0769 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513514.1 760489 D 376619 CDS YP_513515.1 89256153 3952825 764213..764983 1 NC_007880.1 hypothetical protein 764983 3952825 FTL_0776 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513515.1 764213 D 376619 CDS YP_513516.1 89256154 3952826 765074..765262 1 NC_007880.1 hypothetical protein 765262 3952826 FTL_0777 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513516.1 765074 D 376619 CDS YP_513517.1 89256155 3952829 766774..767205 1 NC_007880.1 cold shock protein (DNA-binding) 767205 3952829 FTL_0780 Francisella tularensis subsp. holarctica LVS cold shock protein (DNA-binding) YP_513517.1 766774 D 376619 CDS YP_513518.1 89256156 3952473 complement(join(768494..769048,769048..769374)) 1 NC_007880.1 transposase 769374 isftu1 3952473 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513518.1 768494 R 376619 CDS YP_513519.1 89256157 3952832 complement(769603..771351) 1 NC_007880.1 lipoprotein 771351 3952832 FTL_0784 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513519.1 769603 R 376619 CDS YP_513520.1 89256158 3952833 complement(771418..772290) 1 NC_007880.1 GTP-binding protein 772290 3952833 FTL_0785 Francisella tularensis subsp. holarctica LVS GTP-binding protein YP_513520.1 771418 R 376619 CDS YP_513521.1 89256159 3952834 772353..773486 1 NC_007880.1 N-acetylglucosamine-6-phosphate deacetylase 773486 3952834 FTL_0786 Francisella tularensis subsp. holarctica LVS N-acetylglucosamine-6-phosphate deacetylase YP_513521.1 772353 D 376619 CDS YP_513522.1 89256160 3952835 773490..774128 1 NC_007880.1 glycoprotease family protein 774128 3952835 FTL_0787 Francisella tularensis subsp. holarctica LVS glycoprotease family protein YP_513522.1 773490 D 376619 CDS YP_513523.1 89256161 3952836 774132..774938 1 NC_007880.1 glutamine amidotransferases class-II family protein 774938 3952836 FTL_0788 Francisella tularensis subsp. holarctica LVS glutamine amidotransferases class-II family protein YP_513523.1 774132 D 376619 CDS YP_513524.1 89256162 3952837 774948..776141 1 NC_007880.1 aspartate aminotransferase 776141 3952837 FTL_0789 Francisella tularensis subsp. holarctica LVS aspartate aminotransferase YP_513524.1 774948 D 376619 CDS YP_513525.1 89256163 3952838 776255..777148 1 NC_007880.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 777148 era 3952838 era Francisella tularensis subsp. holarctica LVS GTP-binding protein Era YP_513525.1 776255 D 376619 CDS YP_513526.1 89256164 3951663 777315..777578 1 NC_007880.1 hypothetical protein 777578 3951663 FTL_0791 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513526.1 777315 D 376619 CDS YP_513527.1 89256165 3951667 complement(780918..781574) 1 NC_007880.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 781574 adk 3951667 adk Francisella tularensis subsp. holarctica LVS adenylate kinase YP_513527.1 780918 R 376619 CDS YP_513528.1 89256166 3951668 781701..782705 1 NC_007880.1 hypothetical protein 782705 3951668 FTL_0796 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513528.1 781701 D 376619 CDS YP_513529.1 89256167 3951669 782707..783270 1 NC_007880.1 Type IV pili associated protein 783270 3951669 FTL_0797 Francisella tularensis subsp. holarctica LVS Type IV pili associated protein YP_513529.1 782707 D 376619 CDS YP_513530.1 89256168 3951670 783264..783860 1 NC_007880.1 Type IV pili glycosylation protein 783860 3951670 FTL_0798 Francisella tularensis subsp. holarctica LVS Type IV pili glycosylation protein YP_513530.1 783264 D 376619 CDS YP_513531.1 89256169 3951671 783866..784456 1 NC_007880.1 Type IV pili lipoprotein 784456 3951671 FTL_0799 Francisella tularensis subsp. holarctica LVS Type IV pili lipoprotein YP_513531.1 783866 D 376619 CDS YP_513532.1 89256170 3951672 784469..786241 1 NC_007880.1 Type IV pilin multimeric outer membrane protein 786241 3951672 FTL_0800 Francisella tularensis subsp. holarctica LVS Type IV pilin multimeric outer membrane protein YP_513532.1 784469 D 376619 CDS YP_513533.1 89256171 3951673 786367..786897 1 NC_007880.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 786897 aroK 3951673 aroK Francisella tularensis subsp. holarctica LVS shikimate kinase I YP_513533.1 786367 D 376619 CDS YP_513534.1 89256172 3951674 786894..787973 1 NC_007880.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 787973 aroB 3951674 aroB Francisella tularensis subsp. holarctica LVS 3-dehydroquinate synthase YP_513534.1 786894 D 376619 CDS YP_513535.1 89256173 3951675 complement(788322..788705) 1 NC_007880.1 hypothetical protein 788705 3951675 FTL_0803 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513535.1 788322 R 376619 CDS YP_513536.1 89256174 3951676 788919..789206 1 NC_007880.1 hypothetical protein 789206 3951676 FTL_0804 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513536.1 788919 D 376619 CDS YP_513537.1 89256175 3951677 789223..793287 1 NC_007880.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 793287 3951677 FTL_0805 Francisella tularensis subsp. holarctica LVS bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_513537.1 789223 D 376619 CDS YP_513538.1 89256176 3951678 793447..794955 1 NC_007880.1 amino acid transporter family protein 794955 3951678 FTL_0806 Francisella tularensis subsp. holarctica LVS amino acid transporter family protein YP_513538.1 793447 D 376619 CDS YP_513539.1 89256177 3951679 795031..796215 1 NC_007880.1 major facilitator transporter 796215 3951679 FTL_0807 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_513539.1 795031 D 376619 CDS YP_513540.1 89256178 3951680 796228..797403 1 NC_007880.1 bifunctional 4'-phosphopantothenoylcysteine decarboxylase,phosphopantothenoylcysteine synthetase 797403 3951680 FTL_0808 Francisella tularensis subsp. holarctica LVS bifunctional 4'-phosphopantothenoylcysteine decarboxylase,phosphopantothenoylcysteine synthetase YP_513540.1 796228 D 376619 CDS YP_513541.1 89256179 3951217 complement(798476..798706) 1 NC_007880.1 cation transport regulator 798706 3951217 FTL_0810 Francisella tularensis subsp. holarctica LVS cation transport regulator YP_513541.1 798476 R 376619 CDS YP_513542.1 89256180 3951221 complement(800080..800505) 1 NC_007880.1 hypothetical protein 800505 3951221 FTL_0814 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513542.1 800080 R 376619 CDS YP_513543.1 89256181 3951222 complement(800704..800919) 1 NC_007880.1 PRC-barrel protein 800919 3951222 FTL_0815 Francisella tularensis subsp. holarctica LVS PRC-barrel protein YP_513543.1 800704 R 376619 CDS YP_513544.1 89256182 3951223 complement(800974..801171) 1 NC_007880.1 hypothetical protein 801171 3951223 FTL_0816 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513544.1 800974 R 376619 CDS YP_513545.1 89256183 3951682 803533..804156 1 NC_007880.1 transposase 804156 isftu2 3951682 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513545.1 803533 D 376619 CDS YP_513546.1 89256184 3951227 complement(804244..805245) 1 NC_007880.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 805245 hemH 3951227 hemH Francisella tularensis subsp. holarctica LVS ferrochelatase YP_513546.1 804244 R 376619 CDS YP_513547.1 89256185 3951228 805388..805639 1 NC_007880.1 hypothetical protein 805639 3951228 FTL_0822 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513547.1 805388 D 376619 CDS YP_513548.1 89256186 3951229 805599..805991 1 NC_007880.1 hypothetical protein 805991 3951229 FTL_0823 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513548.1 805599 D 376619 CDS YP_513549.1 89256187 3951233 complement(807237..808466) 1 NC_007880.1 Type IV pili polytopic inner membrane protein 808466 3951233 FTL_0827 Francisella tularensis subsp. holarctica LVS Type IV pili polytopic inner membrane protein YP_513549.1 807237 R 376619 CDS YP_513550.1 89256188 3951234 complement(808481..810262) 1 NC_007880.1 Type IV pili nucleotide binding protein, ABC transporter ATP-binding protein 810262 3951234 FTL_0828 Francisella tularensis subsp. holarctica LVS Type IV pili nucleotide binding protein, ABC transporter ATP-binding protein YP_513550.1 808481 R 376619 CDS YP_513551.1 89256189 3951235 810420..811172 1 NC_007880.1 glycerophosphoryl diester phosphodiesterase 811172 3951235 FTL_0829 Francisella tularensis subsp. holarctica LVS glycerophosphoryl diester phosphodiesterase YP_513551.1 810420 D 376619 CDS YP_513552.1 89256190 3951236 complement(811161..811904) 1 NC_007880.1 molybdopterin binding family protein, fragment 811904 3951236 FTL_0830 Francisella tularensis subsp. holarctica LVS molybdopterin binding family protein, fragment YP_513552.1 811161 R 376619 CDS YP_513553.1 89256191 3950820 812028..814850 1 NC_007880.1 catalyze the formation of cyanophycin which may act to store excess nitrogen; cyanophycin synthetase 814850 3950820 FTL_0831 Francisella tularensis subsp. holarctica LVS cyanophycin synthetase YP_513553.1 812028 D 376619 CDS YP_513554.1 89256192 3950821 814876..816561 1 NC_007880.1 hypothetical protein 816561 3950821 FTL_0832 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513554.1 814876 D 376619 CDS YP_513555.1 89256193 3950822 complement(816566..817045) 1 NC_007880.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 817045 ispF 3950822 ispF Francisella tularensis subsp. holarctica LVS 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_513555.1 816566 R 376619 CDS YP_513556.1 89256194 3950823 complement(817058..817807) 1 NC_007880.1 rhodanese-like family protein 817807 3950823 FTL_0834 Francisella tularensis subsp. holarctica LVS rhodanese-like family protein YP_513556.1 817058 R 376619 CDS YP_513557.1 89256195 3950824 complement(818006..818743) 1 NC_007880.1 aromatic amino acid HAAP transporter 818743 3950824 FTL_0835 Francisella tularensis subsp. holarctica LVS aromatic amino acid HAAP transporter YP_513557.1 818006 R 376619 CDS YP_513558.1 89256196 3950825 complement(818703..819026) 1 NC_007880.1 hypothetical protein 819026 3950825 FTL_0836 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513558.1 818703 R 376619 CDS YP_513559.1 89256197 3950826 complement(819070..820542) 1 NC_007880.1 D-methionine binding transport protein, ABC transporter, membrane and periplasmic protein 820542 3950826 FTL_0837 Francisella tularensis subsp. holarctica LVS D-methionine binding transport protein, ABC transporter, membrane and periplasmic protein YP_513559.1 819070 R 376619 CDS YP_513560.1 89256198 3950827 complement(820520..821572) 1 NC_007880.1 D-methionine transport protein, ABC transporter,ATP-binding subunit 821572 3950827 FTL_0838 Francisella tularensis subsp. holarctica LVS D-methionine transport protein, ABC transporter,ATP-binding subunit YP_513560.1 820520 R 376619 CDS YP_513561.1 89256199 3950828 complement(821559..822173) 1 NC_007880.1 hypothetical protein 822173 3950828 FTL_0839 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513561.1 821559 R 376619 CDS YP_513562.1 89256200 3950829 822809..823150 1 NC_007880.1 hypothetical protein 823150 3950829 FTL_0840 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513562.1 822809 D 376619 CDS YP_513563.1 89256201 3950830 823141..823572 1 NC_007880.1 lipoprotein 823572 3950830 FTL_0841 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513563.1 823141 D 376619 CDS YP_513564.1 89256202 3950831 complement(824028..824249) 1 NC_007880.1 transposase 824249 3950831 FTL_0842 Francisella tularensis subsp. holarctica LVS transposase YP_513564.1 824028 R 376619 CDS YP_513565.1 89256203 3950832 824555..825658 1 NC_007880.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 825658 tgt 3950832 tgt Francisella tularensis subsp. holarctica LVS queuine tRNA-ribosyltransferase YP_513565.1 824555 D 376619 CDS YP_513566.1 89256204 3950833 complement(825879..826484) 1 NC_007880.1 LysR transcriptional regulator family protein 826484 3950833 FTL_0844 Francisella tularensis subsp. holarctica LVS LysR transcriptional regulator family protein YP_513566.1 825879 R 376619 CDS YP_513567.1 89256205 3950834 826646..827461 1 NC_007880.1 hypothetical protein 827461 3950834 FTL_0845 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513567.1 826646 D 376619 CDS YP_513568.1 89256206 3950835 827533..828105 1 NC_007880.1 isochorismatase hydrolase family protein 828105 3950835 FTL_0846 Francisella tularensis subsp. holarctica LVS isochorismatase hydrolase family protein YP_513568.1 827533 D 376619 CDS YP_513569.1 89256207 3950836 828660..829016 1 NC_007880.1 preprotein translocase family protein 829016 3950836 FTL_0847 Francisella tularensis subsp. holarctica LVS preprotein translocase family protein YP_513569.1 828660 D 376619 CDS YP_513570.1 89256208 3950837 829073..831010 1 NC_007880.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 831010 secD 3950837 secD Francisella tularensis subsp. holarctica LVS preprotein translocase subunit SecD YP_513570.1 829073 D 376619 CDS YP_513571.1 89256209 3950838 831029..831973 1 NC_007880.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 831973 secF 3950838 secF Francisella tularensis subsp. holarctica LVS preprotein translocase subunit SecF YP_513571.1 831029 D 376619 CDS YP_513572.1 89256210 3951137 832005..832535 1 NC_007880.1 hypothetical protein 832535 3951137 FTL_0850 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513572.1 832005 D 376619 CDS YP_513573.1 89256211 3951138 832559..833437 1 NC_007880.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 833437 3951138 FTL_0851 Francisella tularensis subsp. holarctica LVS RNA polymerase factor sigma-32 YP_513573.1 832559 D 376619 CDS YP_513574.1 89256212 3951139 833528..834805 1 NC_007880.1 3-phosphoshikimate 1-carboxyvinyltransferase 834805 3951139 FTL_0852 Francisella tularensis subsp. holarctica LVS 3-phosphoshikimate 1-carboxyvinyltransferase YP_513574.1 833528 D 376619 CDS YP_513575.1 89256213 3951140 834808..835398 1 NC_007880.1 hypothetical protein 835398 3951140 FTL_0853 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513575.1 834808 D 376619 CDS YP_513576.1 89256214 3951141 835373..835831 1 NC_007880.1 ribonuclease H 835831 3951141 FTL_0854 Francisella tularensis subsp. holarctica LVS ribonuclease H YP_513576.1 835373 D 376619 CDS YP_513577.1 89256215 3951142 835833..836870 1 NC_007880.1 L-asparaginase 836870 3951142 FTL_0855 Francisella tularensis subsp. holarctica LVS L-asparaginase YP_513577.1 835833 D 376619 CDS YP_513578.1 89256216 3951143 836941..837627 1 NC_007880.1 carbonic anhydrase 837627 3951143 FTL_0856 Francisella tularensis subsp. holarctica LVS carbonic anhydrase YP_513578.1 836941 D 376619 CDS YP_513579.1 89256217 3951144 complement(837914..838519) 1 NC_007880.1 hypothetical protein 838519 3951144 FTL_0857 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513579.1 837914 R 376619 CDS YP_513580.1 89256218 3951145 complement(838583..839455) 1 NC_007880.1 hypothetical protein 839455 3951145 FTL_0858 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513580.1 838583 R 376619 CDS YP_513581.1 89256219 3951146 complement(839464..839685) 1 NC_007880.1 rubredoxin 839685 3951146 FTL_0859 Francisella tularensis subsp. holarctica LVS rubredoxin YP_513581.1 839464 R 376619 CDS YP_513582.1 89256220 3951147 complement(839720..840337) 1 NC_007880.1 hypothetical protein 840337 3951147 FTL_0860 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513582.1 839720 R 376619 CDS YP_513583.1 89256221 3951683 840640..841272 1 NC_007880.1 transposase 841272 isftu2 3951683 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513583.1 840640 D 376619 CDS YP_513584.1 89256222 3951148 841307..842701 1 NC_007880.1 hypothetical protein 842701 3951148 FTL_0862 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513584.1 841307 D 376619 CDS YP_513585.1 89256223 3951149 complement(842733..844007) 1 NC_007880.1 Sodium-dicarboxylate symporter family protein 844007 3951149 FTL_0863 Francisella tularensis subsp. holarctica LVS Sodium-dicarboxylate symporter family protein YP_513585.1 842733 R 376619 CDS YP_513586.1 89256224 3951150 844209..845237 1 NC_007880.1 SIS domain-containing protein 845237 3951150 FTL_0864 Francisella tularensis subsp. holarctica LVS SIS domain-containing protein YP_513586.1 844209 D 376619 CDS YP_513587.1 89256225 3951151 845289..846665 1 NC_007880.1 major facilitator transporter 846665 3951151 FTL_0865 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_513587.1 845289 D 376619 CDS YP_513588.1 89256226 3951152 847053..847361 1 NC_007880.1 IS1 transposase 847361 3951152 FTL_0866 Francisella tularensis subsp. holarctica LVS IS1 transposase YP_513588.1 847053 D 376619 CDS YP_513589.1 89256227 3951153 complement(847543..849000) 1 NC_007880.1 hypothetical protein 849000 3951153 FTL_0867 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513589.1 847543 R 376619 CDS YP_513590.1 89256228 3951684 complement(849036..849671) 1 NC_007880.1 transposase 849671 isftu2 3951684 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513590.1 849036 R 376619 CDS YP_513591.1 89256229 3951154 850138..850377 1 NC_007880.1 hypothetical protein 850377 3951154 FTL_0869 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513591.1 850138 D 376619 CDS YP_513592.1 89256230 3951155 850437..850616 1 NC_007880.1 hypothetical protein 850616 3951155 FTL_0870 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513592.1 850437 D 376619 CDS YP_513593.1 89256231 3951156 850819..851082 1 NC_007880.1 Na+/H+ antiporter 851082 3951156 FTL_0871 Francisella tularensis subsp. holarctica LVS Na+/H+ antiporter YP_513593.1 850819 D 376619 CDS YP_513594.1 89256232 3952346 851082..851582 1 NC_007880.1 hypothetical protein 851582 3952346 FTL_0872 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513594.1 851082 D 376619 CDS YP_513595.1 89256233 3952349 852433..853638 1 NC_007880.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 853638 ispG 3952349 ispG Francisella tularensis subsp. holarctica LVS 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_513595.1 852433 D 376619 CDS YP_513596.1 89256234 3952350 853653..854360 1 NC_007880.1 hypothetical protein 854360 3952350 FTL_0876 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513596.1 853653 D 376619 CDS YP_513597.1 89256235 3952351 854379..856172 1 NC_007880.1 peptidase, M24 family protein 856172 3952351 FTL_0877 Francisella tularensis subsp. holarctica LVS peptidase, M24 family protein YP_513597.1 854379 D 376619 CDS YP_513598.1 89256236 3952352 856270..857334 1 NC_007880.1 DNA/RNA endonuclease family protein 857334 3952352 FTL_0878 Francisella tularensis subsp. holarctica LVS DNA/RNA endonuclease family protein YP_513598.1 856270 D 376619 CDS YP_513599.1 89256237 3952353 complement(857325..858188) 1 NC_007880.1 beta-lactamase 858188 3952353 FTL_0879 Francisella tularensis subsp. holarctica LVS beta-lactamase YP_513599.1 857325 R 376619 CDS YP_513600.1 89256238 3952354 858617..859567 1 NC_007880.1 hypothetical protein 859567 3952354 FTL_0880 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513600.1 858617 D 376619 CDS YP_513601.1 89256239 3952355 complement(859863..860138) 1 NC_007880.1 hypothetical protein 860138 3952355 FTL_0881 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513601.1 859863 R 376619 CDS YP_513602.1 89256240 3952356 complement(860384..861874) 1 NC_007880.1 apolipoprotein N-acyltransferase 861874 3952356 FTL_0882 Francisella tularensis subsp. holarctica LVS apolipoprotein N-acyltransferase YP_513602.1 860384 R 376619 CDS YP_513603.1 89256241 3952357 complement(861874..862716) 1 NC_007880.1 metal ion transporter protein 862716 3952357 FTL_0883 Francisella tularensis subsp. holarctica LVS metal ion transporter protein YP_513603.1 861874 R 376619 CDS YP_513604.1 89256242 3952358 complement(862706..863227) 1 NC_007880.1 hypothetical protein 863227 3952358 FTL_0884 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513604.1 862706 R 376619 CDS YP_513605.1 89256243 3952359 complement(863187..864170) 1 NC_007880.1 phoH-like protein 864170 3952359 FTL_0885 Francisella tularensis subsp. holarctica LVS phoH-like protein YP_513605.1 863187 R 376619 CDS YP_513606.1 89256244 3952360 complement(864174..865502) 1 NC_007880.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 865502 3952360 FTL_0886 Francisella tularensis subsp. holarctica LVS (dimethylallyl)adenosine tRNA methylthiotransferase YP_513606.1 864174 R 376619 CDS YP_513607.1 89256245 3952361 865725..866399 1 NC_007880.1 o-methyltransferase family protein 866399 3952361 FTL_0887 Francisella tularensis subsp. holarctica LVS o-methyltransferase family protein YP_513607.1 865725 D 376619 CDS YP_513608.1 89256246 3952363 867008..867151 1 NC_007880.1 hypothetical protein 867151 3952363 FTL_0889 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513608.1 867008 D 376619 CDS YP_513609.1 89256247 3952364 867167..867760 1 NC_007880.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 867760 3952364 FTL_0890 Francisella tularensis subsp. holarctica LVS thymidine kinase YP_513609.1 867167 D 376619 CDS YP_513610.1 89256248 3950940 868423..869739 1 NC_007880.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 869739 tig 3950940 tig Francisella tularensis subsp. holarctica LVS trigger factor YP_513610.1 868423 D 376619 CDS YP_513611.1 89256249 3950941 869765..870370 1 NC_007880.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 870370 clpP 3950941 clpP Francisella tularensis subsp. holarctica LVS ATP-dependent Clp protease proteolytic subunit YP_513611.1 869765 D 376619 CDS YP_513612.1 89256250 3950942 870394..871647 1 NC_007880.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 871647 clpX 3950942 clpX Francisella tularensis subsp. holarctica LVS ATP-dependent protease ATP-binding subunit ClpX YP_513612.1 870394 D 376619 CDS YP_513613.1 89256251 3950943 871672..873996 1 NC_007880.1 DNA-binding, ATP-dependent protease La 873996 3950943 FTL_0894 Francisella tularensis subsp. holarctica LVS DNA-binding, ATP-dependent protease La YP_513613.1 871672 D 376619 CDS YP_513614.1 89256252 3950944 874083..874355 1 NC_007880.1 histone-like protein HU form B 874355 3950944 FTL_0895 Francisella tularensis subsp. holarctica LVS histone-like protein HU form B YP_513614.1 874083 D 376619 CDS YP_513615.1 89256253 3950945 874468..875898 1 NC_007880.1 hypothetical protein 875898 3950945 FTL_0896 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513615.1 874468 D 376619 CDS YP_513616.1 89256254 3950946 875899..876825 1 NC_007880.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 876825 miaA 3950946 miaA Francisella tularensis subsp. holarctica LVS tRNA delta(2)-isopentenylpyrophosphate transferase YP_513616.1 875899 D 376619 CDS YP_513617.1 89256255 3950947 876936..877265 1 NC_007880.1 host factor I for bacteriophage Q beta replication 877265 3950947 FTL_0898 Francisella tularensis subsp. holarctica LVS host factor I for bacteriophage Q beta replication YP_513617.1 876936 D 376619 CDS YP_513618.1 89256256 3950948 877317..878624 1 NC_007880.1 protease, GTP-binding subunit 878624 3950948 FTL_0899 Francisella tularensis subsp. holarctica LVS protease, GTP-binding subunit YP_513618.1 877317 D 376619 CDS YP_513619.1 89256257 3950949 complement(878635..878994) 1 NC_007880.1 monooxygenase 878994 3950949 FTL_0900 Francisella tularensis subsp. holarctica LVS monooxygenase YP_513619.1 878635 R 376619 CDS YP_513620.1 89256258 3950950 complement(879067..879648) 1 NC_007880.1 monooxygenase family protein 879648 3950950 FTL_0901 Francisella tularensis subsp. holarctica LVS monooxygenase family protein YP_513620.1 879067 R 376619 CDS YP_513621.1 89256259 3950951 complement(879627..879812) 1 NC_007880.1 oxidoreductase 879812 3950951 FTL_0902 Francisella tularensis subsp. holarctica LVS oxidoreductase YP_513621.1 879627 R 376619 CDS YP_513622.1 89256260 3950952 879997..881064 1 NC_007880.1 hypothetical protein 881064 3950952 FTL_0903 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513622.1 879997 D 376619 CDS YP_513623.1 89256261 3950953 881066..881992 1 NC_007880.1 hypothetical protein 881992 3950953 FTL_0904 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513623.1 881066 D 376619 CDS YP_513624.1 89256262 3950954 881993..882478 1 NC_007880.1 low molecular weight (LMW) phosphotyrosine protein phosphatase 882478 3950954 FTL_0905 Francisella tularensis subsp. holarctica LVS low molecular weight (LMW) phosphotyrosine protein phosphatase YP_513624.1 881993 D 376619 CDS YP_513625.1 89256263 3950955 882475..883068 1 NC_007880.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 883068 engB 3950955 engB Francisella tularensis subsp. holarctica LVS ribosome biogenesis GTP-binding protein YsxC YP_513625.1 882475 D 376619 CDS YP_513626.1 89256264 3950958 884563..884856 1 NC_007880.1 hypothetical protein 884856 3950958 FTL_0909 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513626.1 884563 D 376619 CDS YP_513627.1 89256265 3950959 884898..885008 1 NC_007880.1 hypothetical protein 885008 3950959 FTL_0910 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513627.1 884898 D 376619 CDS YP_513628.1 89256266 3952098 888117..888434 1 NC_007880.1 acetolactate synthase small subunit 888434 3952098 FTL_0915 Francisella tularensis subsp. holarctica LVS acetolactate synthase small subunit YP_513628.1 888117 D 376619 CDS YP_513629.1 89256267 3952099 888462..889505 1 NC_007880.1 ketol-acid reductoisomerase 889505 3952099 FTL_0916 Francisella tularensis subsp. holarctica LVS ketol-acid reductoisomerase YP_513629.1 888462 D 376619 CDS YP_513630.1 89256268 3952100 complement(889628..893053) 1 NC_007880.1 transcription-repair coupling factor 893053 3952100 FTL_0917 Francisella tularensis subsp. holarctica LVS transcription-repair coupling factor YP_513630.1 889628 R 376619 CDS YP_513631.1 89256269 3952101 complement(893098..893784) 1 NC_007880.1 hypothetical protein 893784 3952101 FTL_0918 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513631.1 893098 R 376619 CDS YP_513632.1 89256270 3952102 complement(893900..895159) 1 NC_007880.1 hypothetical protein 895159 3952102 FTL_0919 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513632.1 893900 R 376619 CDS YP_513633.1 89256271 3952103 complement(895159..895590) 1 NC_007880.1 hypothetical protein 895590 3952103 FTL_0920 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513633.1 895159 R 376619 CDS YP_513634.1 89256272 3952104 complement(895587..896225) 1 NC_007880.1 endonuclease III 896225 3952104 FTL_0921 Francisella tularensis subsp. holarctica LVS endonuclease III YP_513634.1 895587 R 376619 CDS YP_513635.1 89256273 3952105 complement(896218..896847) 1 NC_007880.1 Iron-sulfur cluster-binding protein 896847 3952105 FTL_0922 Francisella tularensis subsp. holarctica LVS Iron-sulfur cluster-binding protein YP_513635.1 896218 R 376619 CDS YP_513636.1 89256274 3952106 complement(896849..897493) 1 NC_007880.1 cofactor involved in the reduction of disulfides; glutaredoxin 897493 3952106 FTL_0923 Francisella tularensis subsp. holarctica LVS glutaredoxin YP_513636.1 896849 R 376619 CDS YP_513637.1 89256275 3952107 897576..898001 1 NC_007880.1 proton-dependent oligopeptide transporter 898001 3952107 FTL_0924 Francisella tularensis subsp. holarctica LVS proton-dependent oligopeptide transporter YP_513637.1 897576 D 376619 CDS YP_513638.1 89256276 3952108 897902..899122 1 NC_007880.1 proton-dependent oligopeptide transport (POT) family protein 899122 3952108 FTL_0925 Francisella tularensis subsp. holarctica LVS proton-dependent oligopeptide transport (POT) family protein YP_513638.1 897902 D 376619 CDS YP_513639.1 89256277 3952109 complement(899125..899625) 1 NC_007880.1 Ferritin-like protein 899625 3952109 FTL_0926 Francisella tularensis subsp. holarctica LVS Ferritin-like protein YP_513639.1 899125 R 376619 CDS YP_513640.1 89256278 3952110 899831..900814 1 NC_007880.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 900814 3952110 FTL_0927 Francisella tularensis subsp. holarctica LVS lipoyl synthase YP_513640.1 899831 D 376619 CDS YP_513641.1 89256279 3952111 900844..901503 1 NC_007880.1 isoprenoid biosynthesis protein with amidotransferase-like domain 901503 3952111 FTL_0928 Francisella tularensis subsp. holarctica LVS isoprenoid biosynthesis protein with amidotransferase-like domain YP_513641.1 900844 D 376619 CDS YP_513642.1 89256280 3952112 901519..902265 1 NC_007880.1 hypothetical protein 902265 3952112 FTL_0929 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513642.1 901519 D 376619 CDS YP_513643.1 89256281 3950960 902362..902877 1 NC_007880.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 902877 ruvC 3950960 ruvC Francisella tularensis subsp. holarctica LVS Holliday junction resolvase YP_513643.1 902362 D 376619 CDS YP_513644.1 89256282 3950961 902959..904149 1 NC_007880.1 major facilitator transporter 904149 3950961 FTL_0931 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_513644.1 902959 D 376619 CDS YP_513645.1 89256283 3950962 904162..904812 1 NC_007880.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 904812 ruvA 3950962 ruvA Francisella tularensis subsp. holarctica LVS Holliday junction DNA helicase RuvA YP_513645.1 904162 D 376619 CDS YP_513646.1 89256284 3950963 904838..906253 1 NC_007880.1 DNA recombination protein RmuC family protein 906253 3950963 FTL_0933 Francisella tularensis subsp. holarctica LVS DNA recombination protein RmuC family protein YP_513646.1 904838 D 376619 CDS YP_513647.1 89256285 3950964 906432..906881 1 NC_007880.1 hypothetical protein 906881 3950964 FTL_0934 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513647.1 906432 D 376619 CDS YP_513648.1 89256286 3950965 complement(906903..907199) 1 NC_007880.1 hypothetical protein 907199 3950965 FTL_0935 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513648.1 906903 R 376619 CDS YP_513649.1 89256287 3950966 complement(907235..907576) 1 NC_007880.1 hypothetical protein 907576 3950966 FTL_0936 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513649.1 907235 R 376619 CDS YP_513650.1 89256288 3950967 907855..908667 1 NC_007880.1 hypothetical protein 908667 3950967 FTL_0937 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513650.1 907855 D 376619 CDS YP_513651.1 89256289 3950968 complement(908654..909790) 1 NC_007880.1 catalyzes the formation of histamine from L-histidine; histidine decarboxylase 909790 3950968 FTL_0938 Francisella tularensis subsp. holarctica LVS histidine decarboxylase YP_513651.1 908654 R 376619 CDS YP_513652.1 89256290 3950969 complement(909805..910503) 1 NC_007880.1 aldolase/adducin class II family protein 910503 3950969 FTL_0939 Francisella tularensis subsp. holarctica LVS aldolase/adducin class II family protein YP_513652.1 909805 R 376619 CDS YP_513653.1 89256291 3950970 complement(910594..911175) 1 NC_007880.1 methylpurine-DNA glycosylase family protein 911175 3950970 FTL_0940 Francisella tularensis subsp. holarctica LVS methylpurine-DNA glycosylase family protein YP_513653.1 910594 R 376619 CDS YP_513654.1 89256292 3950971 911303..911806 1 NC_007880.1 hypothetical protein 911806 3950971 FTL_0941 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513654.1 911303 D 376619 CDS YP_513655.1 89256293 3950972 911806..912438 1 NC_007880.1 nicotinamide mononucleotide transport (NMT) family protein 912438 3950972 FTL_0942 Francisella tularensis subsp. holarctica LVS nicotinamide mononucleotide transport (NMT) family protein YP_513655.1 911806 D 376619 CDS YP_513656.1 89256294 3950973 912557..913732 1 NC_007880.1 Sodium/hydrogen exchanger family protein 913732 3950973 FTL_0943 Francisella tularensis subsp. holarctica LVS Sodium/hydrogen exchanger family protein YP_513656.1 912557 D 376619 CDS YP_513657.1 89256295 3950975 complement(914065..914529) 1 NC_007880.1 hypothetical protein 914529 3950975 FTL_0945 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513657.1 914065 R 376619 CDS YP_513658.1 89256296 3950976 914886..915884 1 NC_007880.1 major facilitator transporter 915884 3950976 FTL_0946 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_513658.1 914886 D 376619 CDS YP_513659.1 89256297 3950978 complement(917404..918330) 1 NC_007880.1 hypothetical protein 918330 3950978 FTL_0948 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513659.1 917404 R 376619 CDS YP_513660.1 89256298 3950979 918621..919589 1 NC_007880.1 ribose-phosphate pyrophosphokinase 919589 3950979 FTL_0949 Francisella tularensis subsp. holarctica LVS ribose-phosphate pyrophosphokinase YP_513660.1 918621 D 376619 CDS YP_513661.1 89256299 3951256 919689..919979 1 NC_007880.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 919979 3951256 FTL_0950 Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L25 YP_513661.1 919689 D 376619 CDS YP_513662.1 89256300 3951257 920075..921334 1 NC_007880.1 hypothetical protein 921334 3951257 FTL_0951 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513662.1 920075 D 376619 CDS YP_513663.1 89256301 3951258 complement(921539..921685) 1 NC_007880.1 hypothetical protein 921685 3951258 FTL_0952 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513663.1 921539 R 376619 CDS YP_513664.1 89256302 3951259 complement(921901..922347) 1 NC_007880.1 hypothetical protein 922347 3951259 FTL_0953 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513664.1 921901 R 376619 CDS YP_513665.1 89256303 3951260 complement(922930..923205) 1 NC_007880.1 hypothetical protein 923205 3951260 FTL_0954 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513665.1 922930 R 376619 CDS YP_513666.1 89256304 3951261 complement(923220..924311) 1 NC_007880.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 924311 3951261 FTL_0955 Francisella tularensis subsp. holarctica LVS GTP-dependent nucleic acid-binding protein EngD YP_513666.1 923220 R 376619 CDS YP_513667.1 89256305 3951262 complement(924330..924905) 1 NC_007880.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 924905 3951262 FTL_0956 Francisella tularensis subsp. holarctica LVS peptidyl-tRNA hydrolase YP_513667.1 924330 R 376619 CDS YP_513668.1 89256306 3951263 complement(924898..925782) 1 NC_007880.1 Beta-lactamase class A 925782 3951263 FTL_0957 Francisella tularensis subsp. holarctica LVS Beta-lactamase class A YP_513668.1 924898 R 376619 CDS YP_513669.1 89256307 3951264 complement(925791..926636) 1 NC_007880.1 hypothetical protein 926636 3951264 FTL_0958 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513669.1 925791 R 376619 CDS YP_513670.1 89256308 3951265 complement(926676..927494) 1 NC_007880.1 Type IV pili leader peptidase and methylase. 927494 3951265 FTL_0959 Francisella tularensis subsp. holarctica LVS Type IV pili leader peptidase and methylase. YP_513670.1 926676 R 376619 CDS YP_513671.1 89256309 3951266 complement(927498..928898) 1 NC_007880.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 928898 3951266 FTL_0960 Francisella tularensis subsp. holarctica LVS soluble pyridine nucleotide transhydrogenase YP_513671.1 927498 R 376619 CDS YP_513672.1 89256310 3951267 complement(929167..929853) 1 NC_007880.1 potassium channel protein 929853 3951267 FTL_0961 Francisella tularensis subsp. holarctica LVS potassium channel protein YP_513672.1 929167 R 376619 CDS YP_513673.1 89256311 3951268 complement(929877..930149) 1 NC_007880.1 hypothetical protein 930149 3951268 FTL_0962 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513673.1 929877 R 376619 CDS YP_513674.1 89256312 3951269 complement(930229..931686) 1 NC_007880.1 proton-dependent oligopeptide transport (POT) family protein 931686 3951269 FTL_0963 Francisella tularensis subsp. holarctica LVS proton-dependent oligopeptide transport (POT) family protein YP_513674.1 930229 R 376619 CDS YP_513675.1 89256313 3951270 complement(931784..933151) 1 NC_007880.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 933151 hslU 3951270 hslU Francisella tularensis subsp. holarctica LVS ATP-dependent protease ATP-binding subunit HslU YP_513675.1 931784 R 376619 CDS YP_513676.1 89256314 3951271 complement(933159..933710) 1 NC_007880.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 933710 3951271 FTL_0965 Francisella tularensis subsp. holarctica LVS ATP-dependent protease peptidase subunit YP_513676.1 933159 R 376619 CDS YP_513677.1 89256315 3951272 933902..934651 1 NC_007880.1 hypothetical protein 934651 3951272 FTL_0966 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513677.1 933902 D 376619 CDS YP_513678.1 89256316 3951273 complement(934654..935556) 1 NC_007880.1 lipoate-protein ligase A 935556 3951273 FTL_0967 Francisella tularensis subsp. holarctica LVS lipoate-protein ligase A YP_513678.1 934654 R 376619 CDS YP_513679.1 89256317 3951274 935670..936860 1 NC_007880.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 936860 3951274 FTL_0968 Francisella tularensis subsp. holarctica LVS tyrosyl-tRNA synthetase YP_513679.1 935670 D 376619 CDS YP_513680.1 89256318 3952474 complement(join(937264..937818,937818..938144)) 1 NC_007880.1 transposase 938144 isftu1 3952474 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513680.1 937264 R 376619 CDS YP_513681.1 89256319 3951197 938212..939381 1 NC_007880.1 L-lactate dehydrogenase 939381 3951197 FTL_0970 Francisella tularensis subsp. holarctica LVS L-lactate dehydrogenase YP_513681.1 938212 D 376619 CDS YP_513682.1 89256320 3951198 939821..941200 1 NC_007880.1 FAD linked oxidase 941200 3951198 FTL_0971 Francisella tularensis subsp. holarctica LVS FAD linked oxidase YP_513682.1 939821 D 376619 CDS YP_513683.1 89256321 3951201 943905..944750 1 NC_007880.1 50S ribosomal protein L11 methyltransferase 944750 3951201 FTL_0974 Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L11 methyltransferase YP_513683.1 943905 D 376619 CDS YP_513684.1 89256322 3951202 944740..945723 1 NC_007880.1 Nif3 family protein 945723 3951202 FTL_0975 Francisella tularensis subsp. holarctica LVS Nif3 family protein YP_513684.1 944740 D 376619 CDS YP_513685.1 89256323 3951203 945953..948280 1 NC_007880.1 hypothetical protein 948280 3951203 FTL_0976 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513685.1 945953 D 376619 CDS YP_513686.1 89256324 3951204 948522..948908 1 NC_007880.1 hypothetical protein 948908 3951204 FTL_0977 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513686.1 948522 D 376619 CDS YP_513687.1 89256325 3951205 948955..949245 1 NC_007880.1 hypothetical protein 949245 3951205 FTL_0978 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513687.1 948955 D 376619 CDS YP_513688.1 89256326 3951206 949297..949611 1 NC_007880.1 hypothetical protein 949611 3951206 FTL_0979 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513688.1 949297 D 376619 CDS YP_513689.1 89256327 3951207 949617..951023 1 NC_007880.1 hypothetical protein 951023 3951207 FTL_0980 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513689.1 949617 D 376619 CDS YP_513690.1 89256328 3951208 complement(951043..952092) 1 NC_007880.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 952092 3951208 FTL_0981 Francisella tularensis subsp. holarctica LVS DNA polymerase IV YP_513690.1 951043 R 376619 CDS YP_513691.1 89256329 3951209 complement(952099..952701) 1 NC_007880.1 DJ-1/PfpI family protein 952701 3951209 FTL_0982 Francisella tularensis subsp. holarctica LVS DJ-1/PfpI family protein YP_513691.1 952099 R 376619 CDS YP_513692.1 89256330 3951211 complement(953855..955087) 1 NC_007880.1 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta 955087 3951211 FTL_0984 Francisella tularensis subsp. holarctica LVS bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta YP_513692.1 953855 R 376619 CDS YP_513693.1 89256331 3951212 complement(955094..955354) 1 NC_007880.1 glutaredoxin 955354 3951212 FTL_0985 Francisella tularensis subsp. holarctica LVS glutaredoxin YP_513693.1 955094 R 376619 CDS YP_513694.1 89256332 3951213 complement(955358..957130) 1 NC_007880.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 957130 3951213 FTL_0986 Francisella tularensis subsp. holarctica LVS ribonucleotide-diphosphate reductase subunit alpha YP_513694.1 955358 R 376619 CDS YP_513695.1 89256333 3951214 complement(957334..958293) 1 NC_007880.1 Catalyzes the reversible oxidation of malate to oxaloacetate; malate dehydrogenase 958293 3951214 FTL_0987 Francisella tularensis subsp. holarctica LVS malate dehydrogenase YP_513695.1 957334 R 376619 CDS YP_513696.1 89256334 3951215 958456..958968 1 NC_007880.1 hypothetical protein 958968 3951215 FTL_0988 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513696.1 958456 D 376619 CDS YP_513697.1 89256335 3951216 958984..959619 1 NC_007880.1 ubiquinone biosynthesis protein 959619 3951216 FTL_0989 Francisella tularensis subsp. holarctica LVS ubiquinone biosynthesis protein YP_513697.1 958984 D 376619 CDS YP_513698.1 89256336 3952443 complement(959628..960197) 1 NC_007880.1 lipoprotein 960197 3952443 FTL_0990 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513698.1 959628 R 376619 CDS YP_513699.1 89256337 3952445 complement(961721..961981) 1 NC_007880.1 HesA/MoeB/ThiF family protein 961981 3952445 FTL_0993 Francisella tularensis subsp. holarctica LVS HesA/MoeB/ThiF family protein YP_513699.1 961721 R 376619 CDS YP_513700.1 89256338 3952446 complement(961985..963475) 1 NC_007880.1 hypothetical protein 963475 3952446 FTL_0994 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513700.1 961985 R 376619 CDS YP_513701.1 89256339 3952447 complement(963530..964111) 1 NC_007880.1 haloacid dehalogenase 964111 3952447 FTL_0995 Francisella tularensis subsp. holarctica LVS haloacid dehalogenase YP_513701.1 963530 R 376619 CDS YP_513702.1 89256340 3952448 964207..964806 1 NC_007880.1 AhpC/Tsa family protein 964806 3952448 FTL_0996 Francisella tularensis subsp. holarctica LVS AhpC/Tsa family protein YP_513702.1 964207 D 376619 CDS YP_513703.1 89256341 3952449 964871..965374 1 NC_007880.1 hypothetical protein 965374 3952449 FTL_0997 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513703.1 964871 D 376619 CDS YP_513704.1 89256342 3952450 965567..966247 1 NC_007880.1 hypothetical protein 966247 3952450 FTL_0998 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513704.1 965567 D 376619 CDS YP_513705.1 89256343 3952451 966353..966619 1 NC_007880.1 phosphonoacetate hydrolase 966619 3952451 FTL_0999 Francisella tularensis subsp. holarctica LVS phosphonoacetate hydrolase YP_513705.1 966353 D 376619 CDS YP_513706.1 89256344 3952452 966692..966907 1 NC_007880.1 hypothetical protein 966907 3952452 FTL_1000 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513706.1 966692 D 376619 CDS YP_513707.1 89256345 3952453 966911..967522 1 NC_007880.1 hypothetical protein 967522 3952453 FTL_1001 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513707.1 966911 D 376619 CDS YP_513708.1 89256346 3952454 967658..968410 1 NC_007880.1 hypothetical protein 968410 3952454 FTL_1002 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513708.1 967658 D 376619 CDS YP_513709.1 89256347 3952455 968440..969156 1 NC_007880.1 DNA polymerase III subunit epsilon 969156 3952455 FTL_1003 Francisella tularensis subsp. holarctica LVS DNA polymerase III subunit epsilon YP_513709.1 968440 D 376619 CDS YP_513710.1 89256348 3952456 969150..969623 1 NC_007880.1 D-alanyl-D-alanine carboxypeptidase 969623 3952456 FTL_1004 Francisella tularensis subsp. holarctica LVS D-alanyl-D-alanine carboxypeptidase YP_513710.1 969150 D 376619 CDS YP_513711.1 89256349 3952457 969610..971019 1 NC_007880.1 hypothetical protein 971019 3952457 FTL_1005 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513711.1 969610 D 376619 CDS YP_513712.1 89256350 3952461 972468..972929 1 NC_007880.1 aldehyde dehydrogenase 972929 3952461 FTL_1009 Francisella tularensis subsp. holarctica LVS aldehyde dehydrogenase YP_513712.1 972468 D 376619 CDS YP_513713.1 89256351 3951081 973493..973765 1 NC_007880.1 hypothetical protein 973765 3951081 FTL_1012 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513713.1 973493 D 376619 CDS YP_513714.1 89256352 3951082 973779..974510 1 NC_007880.1 hypothetical protein 974510 3951082 FTL_1013 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513714.1 973779 D 376619 CDS YP_513715.1 89256353 3951083 complement(974513..975382) 1 NC_007880.1 oxidative stress transcriptional regulator 975382 3951083 FTL_1014 Francisella tularensis subsp. holarctica LVS oxidative stress transcriptional regulator YP_513715.1 974513 R 376619 CDS YP_513716.1 89256354 3951084 975480..976004 1 NC_007880.1 AhpC/TSA family protein 976004 3951084 FTL_1015 Francisella tularensis subsp. holarctica LVS AhpC/TSA family protein YP_513716.1 975480 D 376619 CDS YP_513717.1 89256355 3951085 976007..976618 1 NC_007880.1 short chain dehydrogenase 976618 3951085 FTL_1016 Francisella tularensis subsp. holarctica LVS short chain dehydrogenase YP_513717.1 976007 D 376619 CDS YP_513718.1 89256356 3951086 complement(976635..977300) 1 NC_007880.1 cytidylate kinase 977300 3951086 FTL_1017 Francisella tularensis subsp. holarctica LVS cytidylate kinase YP_513718.1 976635 R 376619 CDS YP_513719.1 89256357 3951087 complement(977287..978339) 1 NC_007880.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 978339 3951087 FTL_1018 Francisella tularensis subsp. holarctica LVS phosphoserine aminotransferase YP_513719.1 977287 R 376619 CDS YP_513720.1 89256358 3951088 complement(978414..978668) 1 NC_007880.1 hypothetical protein 978668 3951088 FTL_1019 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513720.1 978414 R 376619 CDS YP_513721.1 89256359 3952476 join(978659..978985,978985..979539) 1 NC_007880.1 transposase 979539 isftu1 3952476 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513721.1 978659 D 376619 CDS YP_513722.1 89256360 3951089 complement(979517..980572) 1 NC_007880.1 hypothetical protein 980572 3951089 FTL_1021 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513722.1 979517 R 376619 CDS YP_513723.1 89256361 3951090 complement(980597..981523) 1 NC_007880.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 981523 3951090 FTL_1022 Francisella tularensis subsp. holarctica LVS coproporphyrinogen III oxidase YP_513723.1 980597 R 376619 CDS YP_513724.1 89256362 3951685 981903..982943 1 NC_007880.1 transposase 982943 isftu2 3951685 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513724.1 981903 D 376619 CDS YP_513725.1 89256363 3951091 983058..983393 1 NC_007880.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 983393 rpsF 3951091 rpsF Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S6 YP_513725.1 983058 D 376619 CDS YP_513726.1 89256364 3951092 983409..983627 1 NC_007880.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 983627 rpsR 3951092 rpsR Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S18 YP_513726.1 983409 D 376619 CDS YP_513727.1 89256365 3951093 983646..984101 1 NC_007880.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 984101 rplI 3951093 rplI Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L9 YP_513727.1 983646 D 376619 CDS YP_513728.1 89256366 3951094 984192..985586 1 NC_007880.1 replicative DNA helicase 985586 3951094 FTL_1027 Francisella tularensis subsp. holarctica LVS replicative DNA helicase YP_513728.1 984192 D 376619 CDS YP_513729.1 89256367 3951095 985617..986729 1 NC_007880.1 radical SAM superfamily protein 986729 3951095 FTL_1028 Francisella tularensis subsp. holarctica LVS radical SAM superfamily protein YP_513729.1 985617 D 376619 CDS YP_513730.1 89256368 3951096 986719..987624 1 NC_007880.1 Type IV pili lipoprotein 987624 3951096 FTL_1029 Francisella tularensis subsp. holarctica LVS Type IV pili lipoprotein YP_513730.1 986719 D 376619 CDS YP_513731.1 89256369 3951097 987617..988432 1 NC_007880.1 ribosomal large subunit pseudouridine synthase B 988432 3951097 FTL_1030 Francisella tularensis subsp. holarctica LVS ribosomal large subunit pseudouridine synthase B YP_513731.1 987617 D 376619 CDS YP_513732.1 89256370 3951098 988432..988857 1 NC_007880.1 hypothetical protein 988857 3951098 FTL_1031 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513732.1 988432 D 376619 CDS YP_513733.1 89256371 3952151 988835..989275 1 NC_007880.1 ribosomal-protein-alanine acetyltransferase 989275 3952151 FTL_1032 Francisella tularensis subsp. holarctica LVS ribosomal-protein-alanine acetyltransferase YP_513733.1 988835 D 376619 CDS YP_513734.1 89256372 3952153 992306..993259 1 NC_007880.1 sulfate adenylyltransferase 993259 3952153 FTL_1034 Francisella tularensis subsp. holarctica LVS sulfate adenylyltransferase YP_513734.1 992306 D 376619 CDS YP_513735.1 89256373 3952154 993256..993717 1 NC_007880.1 sulfate adenylyltransferase 993717 3952154 FTL_1035 Francisella tularensis subsp. holarctica LVS sulfate adenylyltransferase YP_513735.1 993256 D 376619 CDS YP_513736.1 89256374 3952155 993877..994338 1 NC_007880.1 adenylylsulfate kinase, fragment 994338 3952155 FTL_1036 Francisella tularensis subsp. holarctica LVS adenylylsulfate kinase, fragment YP_513736.1 993877 D 376619 CDS YP_513737.1 89256375 3952156 994763..995329 1 NC_007880.1 hypothetical protein 995329 3952156 FTL_1037 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513737.1 994763 D 376619 CDS YP_513738.1 89256376 3952157 995381..995746 1 NC_007880.1 hypothetical protein 995746 3952157 FTL_1038 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513738.1 995381 D 376619 CDS YP_513739.1 89256377 3952158 996413..997036 1 NC_007880.1 hypothetical protein 997036 3952158 FTL_1039 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513739.1 996413 D 376619 CDS YP_513740.1 89256378 3952159 997117..997548 1 NC_007880.1 hypothetical protein 997548 3952159 FTL_1040 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513740.1 997117 D 376619 CDS YP_513741.1 89256379 3952160 997638..998615 1 NC_007880.1 octaprenyl-diphosphate synthase 998615 3952160 FTL_1041 Francisella tularensis subsp. holarctica LVS octaprenyl-diphosphate synthase YP_513741.1 997638 D 376619 CDS YP_513742.1 89256380 3952161 complement(998633..999445) 1 NC_007880.1 FKBP-type peptidyl-prolyl cis-trans isomerase family protein 999445 3952161 FTL_1042 Francisella tularensis subsp. holarctica LVS FKBP-type peptidyl-prolyl cis-trans isomerase family protein YP_513742.1 998633 R 376619 CDS YP_513743.1 89256381 3952162 complement(999459..1000262) 1 NC_007880.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1000262 3952162 FTL_1043 Francisella tularensis subsp. holarctica LVS C32 tRNA thiolase YP_513743.1 999459 R 376619 CDS YP_513744.1 89256382 3952163 complement(1000255..1000671) 1 NC_007880.1 hypothetical protein 1000671 3952163 FTL_1044 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513744.1 1000255 R 376619 CDS YP_513745.1 89256383 3952164 complement(1000687..1001298) 1 NC_007880.1 lipoprotein 1001298 3952164 FTL_1045 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513745.1 1000687 R 376619 CDS YP_513746.1 89256384 3952165 complement(1001299..1002702) 1 NC_007880.1 D-alanyl-D-alanine carboxypeptidase 1002702 3952165 FTL_1046 Francisella tularensis subsp. holarctica LVS D-alanyl-D-alanine carboxypeptidase YP_513746.1 1001299 R 376619 CDS YP_513747.1 89256385 3952166 1002958..1003155 1 NC_007880.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1003155 rpsU 3952166 rpsU Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S21 YP_513747.1 1002958 D 376619 CDS YP_513748.1 89256386 3952167 1003216..1003662 1 NC_007880.1 hypothetical protein 1003662 3952167 FTL_1048 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513748.1 1003216 D 376619 CDS YP_513749.1 89256387 3952168 1003683..1005500 1 NC_007880.1 DNA primase 1005500 3952168 FTL_1049 Francisella tularensis subsp. holarctica LVS DNA primase YP_513749.1 1003683 D 376619 CDS YP_513750.1 89256388 3952169 1005525..1007258 1 NC_007880.1 RNA polymerase sigma-70 factor 1007258 3952169 FTL_1050 Francisella tularensis subsp. holarctica LVS RNA polymerase sigma-70 factor YP_513750.1 1005525 D 376619 CDS YP_513751.1 89256389 3951000 1007365..1008615 1 NC_007880.1 NADH dehydrogenase 1008615 3951000 FTL_1051 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase YP_513751.1 1007365 D 376619 CDS YP_513752.1 89256390 3951001 complement(1008728..1008973) 1 NC_007880.1 putative glycosidase 1008973 3951001 FTL_1052 Francisella tularensis subsp. holarctica LVS putative glycosidase YP_513752.1 1008728 R 376619 CDS YP_513753.1 89256391 3951002 complement(1008946..1009395) 1 NC_007880.1 putative alpha-xylosidase 1009395 3951002 FTL_1053 Francisella tularensis subsp. holarctica LVS putative alpha-xylosidase YP_513753.1 1008946 R 376619 CDS YP_513754.1 89256392 3951003 complement(1009400..1009840) 1 NC_007880.1 putative alpha-xylosidase 1009840 3951003 FTL_1054 Francisella tularensis subsp. holarctica LVS putative alpha-xylosidase YP_513754.1 1009400 R 376619 CDS YP_513755.1 89256393 3951007 complement(1012669..1013289) 1 NC_007880.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 1013289 lipB 3951007 lipB Francisella tularensis subsp. holarctica LVS lipoate-protein ligase B YP_513755.1 1012669 R 376619 CDS YP_513756.1 89256394 3951008 complement(1013299..1013583) 1 NC_007880.1 hypothetical protein 1013583 3951008 FTL_1059 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513756.1 1013299 R 376619 CDS YP_513757.1 89256395 3951009 complement(1013616..1014950) 1 NC_007880.1 D-alanyl-D-alanine carboxypeptidase 1014950 3951009 FTL_1060 Francisella tularensis subsp. holarctica LVS D-alanyl-D-alanine carboxypeptidase YP_513757.1 1013616 R 376619 CDS YP_513758.1 89256396 3951010 1015107..1015628 1 NC_007880.1 inorganic pyrophosphatase 1015628 3951010 FTL_1061 Francisella tularensis subsp. holarctica LVS inorganic pyrophosphatase YP_513758.1 1015107 D 376619 CDS YP_513759.1 89256397 3951011 1015719..1016267 1 NC_007880.1 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 1016267 3951011 FTL_1062 Francisella tularensis subsp. holarctica LVS 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_513759.1 1015719 D 376619 CDS YP_513760.1 89256398 3951012 1016275..1016901 1 NC_007880.1 hypothetical protein 1016901 3951012 FTL_1063 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513760.1 1016275 D 376619 CDS YP_513761.1 89256399 3951013 1016888..1017721 1 NC_007880.1 hypothetical protein 1017721 3951013 FTL_1064 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513761.1 1016888 D 376619 CDS YP_513762.1 89256400 3951014 1017795..1018526 1 NC_007880.1 ABC transporter ATP-binding protein 1018526 3951014 FTL_1065 Francisella tularensis subsp. holarctica LVS ABC transporter ATP-binding protein YP_513762.1 1017795 D 376619 CDS YP_513763.1 89256401 3951015 1018575..1019168 1 NC_007880.1 fumarylacetoacetate hydrolase family protein 1019168 3951015 FTL_1066 Francisella tularensis subsp. holarctica LVS fumarylacetoacetate hydrolase family protein YP_513763.1 1018575 D 376619 CDS YP_513764.1 89256402 3951016 1019181..1021013 1 NC_007880.1 hypothetical protein 1021013 3951016 FTL_1067 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513764.1 1019181 D 376619 CDS YP_513765.1 89256403 3951017 1021016..1021792 1 NC_007880.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1021792 truA 3951017 truA Francisella tularensis subsp. holarctica LVS tRNA pseudouridine synthase A YP_513765.1 1021016 D 376619 CDS YP_513766.1 89256404 3951018 1021848..1022960 1 NC_007880.1 amino acid permease 1022960 3951018 FTL_1069 Francisella tularensis subsp. holarctica LVS amino acid permease YP_513766.1 1021848 D 376619 CDS YP_513767.1 89256405 3951019 1023146..1023391 1 NC_007880.1 hypothetical protein 1023391 3951019 FTL_1070 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513767.1 1023146 D 376619 CDS YP_513768.1 89256406 3951701 1023479..1025029 1 NC_007880.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1025029 guaA 3951701 guaA Francisella tularensis subsp. holarctica LVS GMP synthase YP_513768.1 1023479 D 376619 CDS YP_513769.1 89256407 3951702 1025111..1026958 1 NC_007880.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1026958 3951702 FTL_1072 Francisella tularensis subsp. holarctica LVS 1-deoxy-D-xylulose-5-phosphate synthase YP_513769.1 1025111 D 376619 CDS YP_513770.1 89256408 3951703 1026974..1027309 1 NC_007880.1 hypothetical protein 1027309 3951703 FTL_1073 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513770.1 1026974 D 376619 CDS YP_513771.1 89256409 3951704 1027331..1027960 1 NC_007880.1 GDSL-like lipase/acylhydrolase family protein 1027960 3951704 FTL_1074 Francisella tularensis subsp. holarctica LVS GDSL-like lipase/acylhydrolase family protein YP_513771.1 1027331 D 376619 CDS YP_513772.1 89256410 3951705 complement(1027970..1028560) 1 NC_007880.1 hypothetical protein 1028560 3951705 FTL_1075 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513772.1 1027970 R 376619 CDS YP_513773.1 89256411 3951706 1028678..1029403 1 NC_007880.1 short chain dehydrogenase family protein 1029403 3951706 FTL_1076 Francisella tularensis subsp. holarctica LVS short chain dehydrogenase family protein YP_513773.1 1028678 D 376619 CDS YP_513774.1 89256412 3951707 1029467..1030513 1 NC_007880.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1030513 ruvB 3951707 ruvB Francisella tularensis subsp. holarctica LVS Holliday junction DNA helicase RuvB YP_513774.1 1029467 D 376619 CDS YP_513775.1 89256413 3951709 complement(1031796..1031999) 1 NC_007880.1 helix-turn-helix family protein 1031999 3951709 FTL_1079 Francisella tularensis subsp. holarctica LVS helix-turn-helix family protein YP_513775.1 1031796 R 376619 CDS YP_513776.1 89256414 3951710 complement(1032172..1032549) 1 NC_007880.1 hypothetical protein 1032549 3951710 FTL_1080 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513776.1 1032172 R 376619 CDS YP_513777.1 89256415 3951711 1032902..1033321 1 NC_007880.1 hypothetical protein 1033321 3951711 FTL_1081 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513777.1 1032902 D 376619 CDS YP_513778.1 89256416 3951712 1033290..1033622 1 NC_007880.1 hypothetical protein 1033622 3951712 FTL_1082 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513778.1 1033290 D 376619 CDS YP_513779.1 89256417 3951713 complement(1033607..1033897) 1 NC_007880.1 hypothetical protein 1033897 3951713 FTL_1083 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513779.1 1033607 R 376619 CDS YP_513780.1 89256418 3951714 complement(1034256..1034582) 1 NC_007880.1 hypothetical protein 1034582 3951714 FTL_1084 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513780.1 1034256 R 376619 CDS YP_513781.1 89256419 3951715 complement(1034661..1034876) 1 NC_007880.1 hypothetical protein 1034876 3951715 FTL_1085 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513781.1 1034661 R 376619 CDS YP_513782.1 89256420 3951716 1035243..1035866 1 NC_007880.1 proton-dependent oligopeptide transporter (POT) family protein 1035866 3951716 FTL_1086 Francisella tularensis subsp. holarctica LVS proton-dependent oligopeptide transporter (POT) family protein YP_513782.1 1035243 D 376619 CDS YP_513783.1 89256421 3951686 complement(1035817..1036443) 1 NC_007880.1 transposase 1036443 isftu2 3951686 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513783.1 1035817 R 376619 CDS YP_513784.1 89256422 3951717 complement(1036686..1037039) 1 NC_007880.1 hypothetical protein 1037039 3951717 FTL_1088 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513784.1 1036686 R 376619 CDS YP_513785.1 89256423 3951718 complement(1037417..1038172) 1 NC_007880.1 choloylglycine hydrolase family protein 1038172 3951718 FTL_1089 Francisella tularensis subsp. holarctica LVS choloylglycine hydrolase family protein YP_513785.1 1037417 R 376619 CDS YP_513786.1 89256424 3951719 complement(1038266..1039018) 1 NC_007880.1 rRNA methyltransferase 1039018 3951719 FTL_1090 Francisella tularensis subsp. holarctica LVS rRNA methyltransferase YP_513786.1 1038266 R 376619 CDS YP_513787.1 89256425 3950883 1041501..1042355 1 NC_007880.1 this fusion consists of methionine sulfoxide B reductase at the N-terminus and A at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion protein of these enzymes with thioredoxin provides protection against oxidative stress in Neisseria gonorrhoeae; bifunctional methionine sulfoxide reductase B/A protein 1042355 3950883 FTL_1093 Francisella tularensis subsp. holarctica LVS bifunctional methionine sulfoxide reductase B/A protein YP_513787.1 1041501 D 376619 CDS YP_513788.1 89256426 3950886 complement(1043815..1044936) 1 NC_007880.1 lipoprotein 1044936 3950886 FTL_1096 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513788.1 1043815 R 376619 CDS YP_513789.1 89256427 3950887 complement(1044957..1045247) 1 NC_007880.1 hypothetical protein 1045247 3950887 FTL_1097 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513789.1 1044957 R 376619 CDS YP_513790.1 89256428 3950890 complement(1046424..1046831) 1 NC_007880.1 hypothetical protein 1046831 3950890 FTL_1100 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513790.1 1046424 R 376619 CDS YP_513791.1 89256429 3950891 1046862..1047197 1 NC_007880.1 hypothetical protein 1047197 3950891 FTL_1101 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513791.1 1046862 D 376619 CDS YP_513792.1 89256430 3950895 complement(1049106..1049552) 1 NC_007880.1 hypothetical protein 1049552 3950895 FTL_1105 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513792.1 1049106 R 376619 CDS YP_513793.1 89256431 3950896 1049708..1052305 1 NC_007880.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1052305 alaS 3950896 alaS Francisella tularensis subsp. holarctica LVS alanyl-tRNA synthetase YP_513793.1 1049708 D 376619 CDS YP_513794.1 89256432 3950897 1052322..1053695 1 NC_007880.1 hypothetical protein 1053695 3950897 FTL_1107 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513794.1 1052322 D 376619 CDS YP_513795.1 89256433 3950898 1053698..1055077 1 NC_007880.1 cytosol aminopeptidase 1055077 3950898 FTL_1108 Francisella tularensis subsp. holarctica LVS cytosol aminopeptidase YP_513795.1 1053698 D 376619 CDS YP_513796.2 161353781 3950899 1055211..1056176 1 NC_007880.1 transaldolase B 1056176 3950899 FTL_1109 Francisella tularensis subsp. holarctica LVS transaldolase B YP_513796.2 1055211 D 376619 CDS YP_513797.1 89256435 3950900 1056202..1056660 1 NC_007880.1 hypothetical protein 1056660 3950900 FTL_1110 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513797.1 1056202 D 376619 CDS YP_513798.1 89256436 3951353 complement(1056872..1057183) 1 NC_007880.1 isochorismatase hydrolase family protein 1057183 3951353 FTL_1111 Francisella tularensis subsp. holarctica LVS isochorismatase hydrolase family protein YP_513798.1 1056872 R 376619 CDS YP_513799.1 89256437 3951687 1057410..1058180 1 NC_007880.1 transposase 1058180 isftu2 3951687 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513799.1 1057410 D 376619 CDS YP_513800.1 89256438 3951354 complement(1058231..1058908) 1 NC_007880.1 hypothetical protein 1058908 3951354 FTL_1113 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513800.1 1058231 R 376619 CDS YP_513801.1 89256439 3951355 complement(1058905..1059411) 1 NC_007880.1 isochorismatase hydrolase family protein 1059411 3951355 FTL_1114 Francisella tularensis subsp. holarctica LVS isochorismatase hydrolase family protein YP_513801.1 1058905 R 376619 CDS YP_513802.1 89256440 3951356 1060034..1060780 1 NC_007880.1 hypothetical protein 1060780 3951356 FTL_1115 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513802.1 1060034 D 376619 CDS YP_513803.1 89256441 3951357 1060774..1062789 1 NC_007880.1 ATP-dependent DNA helicase 1062789 3951357 FTL_1116 Francisella tularensis subsp. holarctica LVS ATP-dependent DNA helicase YP_513803.1 1060774 D 376619 CDS YP_513804.1 89256442 3951358 1062845..1063675 1 NC_007880.1 hypothetical protein 1063675 3951358 FTL_1117 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513804.1 1062845 D 376619 CDS YP_513805.1 89256443 3951359 complement(1063806..1064792) 1 NC_007880.1 hypothetical protein 1064792 3951359 FTL_1118 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513805.1 1063806 R 376619 CDS YP_513806.1 89256444 3951360 1064986..1065846 1 NC_007880.1 Required for efficient pilin antigenic variation; recombination associated protein 1065846 rdgC 3951360 rdgC Francisella tularensis subsp. holarctica LVS recombination associated protein YP_513806.1 1064986 D 376619 CDS YP_513807.1 89256445 3951361 1065851..1066108 1 NC_007880.1 hypothetical protein 1066108 3951361 FTL_1120 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513807.1 1065851 D 376619 CDS YP_513808.1 89256446 3951362 1066772..1067575 1 NC_007880.1 hypothetical protein 1067575 3951362 FTL_1121 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513808.1 1066772 D 376619 CDS YP_513809.1 89256447 3951363 1067575..1068126 1 NC_007880.1 hypothetical protein 1068126 3951363 FTL_1122 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513809.1 1067575 D 376619 CDS YP_513810.1 89256448 3951364 1068466..1069368 1 NC_007880.1 hypothetical protein 1069368 3951364 FTL_1123 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513810.1 1068466 D 376619 CDS YP_513811.1 89256449 3951365 1069405..1069866 1 NC_007880.1 hypothetical protein 1069866 3951365 FTL_1124 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513811.1 1069405 D 376619 CDS YP_513812.1 89256450 3951366 complement(1069990..1071246) 1 NC_007880.1 transcriptional regulator 1071246 3951366 FTL_1125 Francisella tularensis subsp. holarctica LVS transcriptional regulator YP_513812.1 1069990 R 376619 CDS YP_513813.1 89256451 3951367 complement(1071249..1071476) 1 NC_007880.1 transcriptional regulator 1071476 3951367 FTL_1126 Francisella tularensis subsp. holarctica LVS transcriptional regulator YP_513813.1 1071249 R 376619 CDS YP_513814.1 89256452 3952477 complement(join(1072264..1072818,1072818..1073144)) 1 NC_007880.1 transposase 1073144 isftu1 3952477 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513814.1 1072264 R 376619 CDS YP_513815.1 89256453 3951368 1073135..1073404 1 NC_007880.1 hypothetical protein 1073404 3951368 FTL_1128 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513815.1 1073135 D 376619 CDS YP_513816.1 89256454 3951369 1073497..1073988 1 NC_007880.1 acetyltransferase 1073988 3951369 FTL_1129 Francisella tularensis subsp. holarctica LVS acetyltransferase YP_513816.1 1073497 D 376619 CDS YP_513817.1 89256455 3951370 complement(1073966..1074358) 1 NC_007880.1 ribosomal RNA small subunit methyltransferase 1074358 3951370 FTL_1130 Francisella tularensis subsp. holarctica LVS ribosomal RNA small subunit methyltransferase YP_513817.1 1073966 R 376619 CDS YP_513818.1 89256456 3951371 complement(1074770..1075246) 1 NC_007880.1 Sun protein 1075246 3951371 FTL_1131 Francisella tularensis subsp. holarctica LVS Sun protein YP_513818.1 1074770 R 376619 CDS YP_513819.1 89256457 3951039 complement(1075246..1076034) 1 NC_007880.1 inositol-1-monophosphatase 1076034 3951039 FTL_1132 Francisella tularensis subsp. holarctica LVS inositol-1-monophosphatase YP_513819.1 1075246 R 376619 CDS YP_513820.1 89256458 3951040 complement(1076121..1077173) 1 NC_007880.1 hypothetical protein 1077173 3951040 FTL_1133 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513820.1 1076121 R 376619 CDS YP_513821.1 89256459 3951041 complement(1077263..1078471) 1 NC_007880.1 hypothetical protein 1078471 3951041 FTL_1134 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513821.1 1077263 R 376619 CDS YP_513822.1 89256460 3951043 complement(1079269..1079553) 1 NC_007880.1 hypothetical protein 1079553 3951043 FTL_1136 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513822.1 1079269 R 376619 CDS YP_513823.1 89256461 3951044 complement(1079634..1080893) 1 NC_007880.1 3-oxoacyl-ACP synthase 1080893 3951044 FTL_1137 Francisella tularensis subsp. holarctica LVS 3-oxoacyl-ACP synthase YP_513823.1 1079634 R 376619 CDS YP_513824.1 89256462 3951045 complement(1080973..1081257) 1 NC_007880.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1081257 acpP 3951045 acpP Francisella tularensis subsp. holarctica LVS acyl carrier protein YP_513824.1 1080973 R 376619 CDS YP_513825.1 89256463 3951046 complement(1081354..1082097) 1 NC_007880.1 3-oxoacyl-(acyl-carrier-protein) reductase 1082097 3951046 FTL_1139 Francisella tularensis subsp. holarctica LVS 3-oxoacyl-(acyl-carrier-protein) reductase YP_513825.1 1081354 R 376619 CDS YP_513826.1 89256464 3951047 complement(1082111..1083031) 1 NC_007880.1 malonyl CoA-acyl carrier protein transacylase 1083031 3951047 FTL_1140 Francisella tularensis subsp. holarctica LVS malonyl CoA-acyl carrier protein transacylase YP_513826.1 1082111 R 376619 CDS YP_513827.1 89256465 3951048 complement(1083079..1084050) 1 NC_007880.1 3-oxoacyl-ACP synthase 1084050 3951048 FTL_1141 Francisella tularensis subsp. holarctica LVS 3-oxoacyl-ACP synthase YP_513827.1 1083079 R 376619 CDS YP_513828.1 89256466 3951049 complement(1084147..1085193) 1 NC_007880.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 1085193 3951049 FTL_1142 Francisella tularensis subsp. holarctica LVS putative glycerol-3-phosphate acyltransferase PlsX YP_513828.1 1084147 R 376619 CDS YP_513829.1 89256467 3951050 complement(1085292..1085474) 1 NC_007880.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1085474 rpmF 3951050 rpmF Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L32 YP_513829.1 1085292 R 376619 CDS YP_513830.1 89256468 3951051 complement(1085518..1086021) 1 NC_007880.1 hypothetical protein 1086021 3951051 FTL_1144 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513830.1 1085518 R 376619 CDS YP_513831.1 89256469 3951052 1086160..1088151 1 NC_007880.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1088151 3951052 FTL_1145 Francisella tularensis subsp. holarctica LVS transketolase YP_513831.1 1086160 D 376619 CDS YP_513832.1 89256470 3951053 1088189..1089190 1 NC_007880.1 glyceraldehyde-3-phosphate dehydrogenase 1089190 3951053 FTL_1146 Francisella tularensis subsp. holarctica LVS glyceraldehyde-3-phosphate dehydrogenase YP_513832.1 1088189 D 376619 CDS YP_513833.1 89256471 3951054 1089209..1090387 1 NC_007880.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1090387 pgk 3951054 pgk Francisella tularensis subsp. holarctica LVS phosphoglycerate kinase YP_513833.1 1089209 D 376619 CDS YP_513834.1 89256472 3951055 1090403..1091839 1 NC_007880.1 pyruvate kinase 1091839 3951055 FTL_1148 Francisella tularensis subsp. holarctica LVS pyruvate kinase YP_513834.1 1090403 D 376619 CDS YP_513835.1 89256473 3951056 1091858..1092922 1 NC_007880.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 1092922 3951056 FTL_1149 Francisella tularensis subsp. holarctica LVS fructose-1,6-bisphosphate aldolase YP_513835.1 1091858 D 376619 CDS YP_513836.1 89256474 3951057 complement(1093090..1093644) 1 NC_007880.1 Alpha,alpha-trehalase. 1093644 3951057 FTL_1150 Francisella tularensis subsp. holarctica LVS Alpha,alpha-trehalase. YP_513836.1 1093090 R 376619 CDS YP_513837.1 89256475 3951058 complement(1093524..1094570) 1 NC_007880.1 trehalase, pseuodgene 1094570 3951058 FTL_1151 Francisella tularensis subsp. holarctica LVS trehalase, pseuodgene YP_513837.1 1093524 R 376619 CDS YP_513838.1 89256476 3952478 join(1094950..1095274,1095274..1095830) 1 NC_007880.1 transposase 1095830 isftu1 3952478 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513838.1 1094950 D 376619 CDS YP_513839.1 89256477 3951412 1096796..1097197 1 NC_007880.1 hypothetical protein 1097197 3951412 FTL_1155 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513839.1 1096796 D 376619 CDS YP_513840.1 89256478 3951413 1097207..1097410 1 NC_007880.1 hypothetical protein 1097410 3951413 FTL_1156 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513840.1 1097207 D 376619 CDS YP_513841.1 89256479 3951414 1097491..1098045 1 NC_007880.1 intracellular growth locus, subunit A 1098045 3951414 FTL_1157 Francisella tularensis subsp. holarctica LVS intracellular growth locus, subunit A YP_513841.1 1097491 D 376619 CDS YP_513842.1 89256480 3951415 1098059..1099579 1 NC_007880.1 intracellular growth locus, subunit B 1099579 3951415 FTL_1158 Francisella tularensis subsp. holarctica LVS intracellular growth locus, subunit B YP_513842.1 1098059 D 376619 CDS YP_513843.1 89256481 3951416 1099596..1100225 1 NC_007880.1 intracellular growth locus, subunit C 1100225 3951416 FTL_1159 Francisella tularensis subsp. holarctica LVS intracellular growth locus, subunit C YP_513843.1 1099596 D 376619 CDS YP_513844.1 89256482 3951417 1100246..1101442 1 NC_007880.1 intracellular growth locus, subunit D 1101442 3951417 FTL_1160 Francisella tularensis subsp. holarctica LVS intracellular growth locus, subunit D YP_513844.1 1100246 D 376619 CDS YP_513845.1 89256483 3951418 complement(1101449..1102024) 1 NC_007880.1 hypothetical protein 1102024 3951418 FTL_1161 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513845.1 1101449 R 376619 CDS YP_513846.1 89256484 3951419 complement(1102042..1106028) 1 NC_007880.1 hypothetical protein 1106028 3951419 FTL_1162 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513846.1 1102042 R 376619 CDS YP_513847.1 89256485 3951420 complement(1106068..1106841) 1 NC_007880.1 hypothetical protein 1106841 3951420 FTL_1163 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513847.1 1106068 R 376619 CDS YP_513848.1 89256486 3951421 complement(1106807..1107958) 1 NC_007880.1 hypothetical protein 1107958 3951421 FTL_1164 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513848.1 1106807 R 376619 CDS YP_513849.1 89256487 3951422 complement(1107980..1108603) 1 NC_007880.1 hypothetical protein 1108603 3951422 FTL_1165 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513849.1 1107980 R 376619 CDS YP_513850.1 89256488 3951423 complement(1108616..1110046) 1 NC_007880.1 hypothetical protein 1110046 3951423 FTL_1166 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513850.1 1108616 R 376619 CDS YP_513851.1 89256489 3951424 complement(1110059..1110580) 1 NC_007880.1 hypothetical protein 1110580 3951424 FTL_1167 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513851.1 1110059 R 376619 CDS YP_513852.1 89256490 3951425 complement(1110648..1112312) 1 NC_007880.1 hypothetical protein 1112312 3951425 FTL_1168 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513852.1 1110648 R 376619 CDS YP_513853.1 89256491 3951426 complement(1112317..1112811) 1 NC_007880.1 hypothetical protein 1112811 3951426 FTL_1169 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513853.1 1112317 R 376619 CDS YP_513854.1 89256492 3951427 complement(1112824..1113201) 1 NC_007880.1 hypothetical protein 1113201 3951427 FTL_1170 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513854.1 1112824 R 376619 CDS YP_513855.1 89256493 3951428 complement(1113191..1116472) 1 NC_007880.1 hypothetical protein 1116472 3951428 FTL_1171 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513855.1 1113191 R 376619 CDS YP_513856.1 89256494 3951448 complement(1116477..1118939) 1 NC_007880.1 hypothetical protein 1118939 3951448 FTL_1172 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513856.1 1116477 R 376619 CDS YP_513857.1 89256495 3951449 complement(1124519..1125088) 1 NC_007880.1 hypothetical protein 1125088 3951449 FTL_1173 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513857.1 1124519 R 376619 CDS YP_513858.1 89256496 3951450 complement(1125350..1126273) 1 NC_007880.1 cystathionine beta-synthase (cystein synthase) 1126273 3951450 FTL_1174 Francisella tularensis subsp. holarctica LVS cystathionine beta-synthase (cystein synthase) YP_513858.1 1125350 R 376619 CDS YP_513859.1 89256497 3951452 1127680..1128132 1 NC_007880.1 LysR transcriptional regulator family protein 1128132 3951452 FTL_1176 Francisella tularensis subsp. holarctica LVS LysR transcriptional regulator family protein YP_513859.1 1127680 D 376619 CDS YP_513860.1 89256498 3951453 complement(1128805..1130157) 1 NC_007880.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 1130157 trmE 3951453 trmE Francisella tularensis subsp. holarctica LVS tRNA modification GTPase TrmE YP_513860.1 1128805 R 376619 CDS YP_513861.1 89256499 3951454 complement(1130163..1130408) 1 NC_007880.1 hypothetical protein 1130408 3951454 FTL_1178 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513861.1 1130163 R 376619 CDS YP_513862.1 89256500 3951455 1130527..1130823 1 NC_007880.1 sigma-54 modulation protein 1130823 3951455 FTL_1179 Francisella tularensis subsp. holarctica LVS sigma-54 modulation protein YP_513862.1 1130527 D 376619 CDS YP_513863.1 89256501 3951456 1130860..1131315 1 NC_007880.1 PEP-dependent sugar PTS system family protein 1131315 3951456 FTL_1180 Francisella tularensis subsp. holarctica LVS PEP-dependent sugar PTS system family protein YP_513863.1 1130860 D 376619 CDS YP_513864.1 89256502 3951457 1131308..1132051 1 NC_007880.1 SpoU rRNA methylase family protein 1132051 3951457 FTL_1181 Francisella tularensis subsp. holarctica LVS SpoU rRNA methylase family protein YP_513864.1 1131308 D 376619 CDS YP_513865.1 89256503 3951458 1132053..1132616 1 NC_007880.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1132616 rnhB 3951458 rnhB Francisella tularensis subsp. holarctica LVS ribonuclease HII YP_513865.1 1132053 D 376619 CDS YP_513866.1 89256504 3951459 1132609..1133880 1 NC_007880.1 Sodium-solute symporter family protein 1133880 3951459 FTL_1183 Francisella tularensis subsp. holarctica LVS Sodium-solute symporter family protein YP_513866.1 1132609 D 376619 CDS YP_513867.1 89256505 3951460 complement(1133877..1134284) 1 NC_007880.1 ClpXP protease specificity-enhancing factor 1134284 3951460 FTL_1184 Francisella tularensis subsp. holarctica LVS ClpXP protease specificity-enhancing factor YP_513867.1 1133877 R 376619 CDS YP_513868.1 89256506 3951461 complement(1134286..1134855) 1 NC_007880.1 macrophage growth locus subunit A 1134855 3951461 FTL_1185 Francisella tularensis subsp. holarctica LVS macrophage growth locus subunit A YP_513868.1 1134286 R 376619 CDS YP_513869.1 89256507 3951462 complement(1134963..1135352) 1 NC_007880.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 1135352 rpsI 3951462 rpsI Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S9 YP_513869.1 1134963 R 376619 CDS YP_513870.1 89256508 3951463 complement(1135368..1135796) 1 NC_007880.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 1135796 rplM 3951463 rplM Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L13 YP_513870.1 1135368 R 376619 CDS YP_513871.1 89256509 3951464 complement(1135935..1137119) 1 NC_007880.1 hypothetical protein 1137119 3951464 FTL_1188 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513871.1 1135935 R 376619 CDS YP_513872.1 89256510 3951465 complement(1137112..1138263) 1 NC_007880.1 membrane-bound lytic murein transglycosylase A (MLT) family protein 1138263 3951465 FTL_1189 Francisella tularensis subsp. holarctica LVS membrane-bound lytic murein transglycosylase A (MLT) family protein YP_513872.1 1137112 R 376619 CDS YP_513873.1 89256511 3951466 1138367..1138954 1 NC_007880.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 1138954 3951466 FTL_1190 Francisella tularensis subsp. holarctica LVS heat shock protein GrpE YP_513873.1 1138367 D 376619 CDS YP_513874.1 89256512 3951467 1139055..1140983 1 NC_007880.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 1140983 dnaK 3951467 dnaK Francisella tularensis subsp. holarctica LVS molecular chaperone DnaK YP_513874.1 1139055 D 376619 CDS YP_513875.1 89256513 3951294 1141072..1142187 1 NC_007880.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 1142187 3951294 FTL_1192 Francisella tularensis subsp. holarctica LVS chaperone protein DnaJ YP_513875.1 1141072 D 376619 CDS YP_513876.1 89256514 3951295 complement(1142201..1142989) 1 NC_007880.1 LysR transcriptional regulator family protein 1142989 3951295 FTL_1193 Francisella tularensis subsp. holarctica LVS LysR transcriptional regulator family protein YP_513876.1 1142201 R 376619 CDS YP_513877.1 89256515 3951296 1143082..1143330 1 NC_007880.1 pirin family protein 1143330 3951296 FTL_1194 Francisella tularensis subsp. holarctica LVS pirin family protein YP_513877.1 1143082 D 376619 CDS YP_513878.1 89256516 3952479 join(1143354..1143680,1143680..1144234) 1 NC_007880.1 transposase 1144234 isftu1 3952479 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513878.1 1143354 D 376619 CDS YP_513879.1 89256517 3951297 1144282..1145118 1 NC_007880.1 hypothetical protein 1145118 3951297 FTL_1196 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513879.1 1144282 D 376619 CDS YP_513880.1 89256518 3951298 1145204..1146217 1 NC_007880.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1146217 pheS 3951298 pheS Francisella tularensis subsp. holarctica LVS phenylalanyl-tRNA synthetase subunit alpha YP_513880.1 1145204 D 376619 CDS YP_513881.1 89256519 3951299 1146238..1148610 1 NC_007880.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1148610 pheT 3951299 pheT Francisella tularensis subsp. holarctica LVS phenylalanyl-tRNA synthetase subunit beta YP_513881.1 1146238 D 376619 CDS YP_513882.1 89256520 3951300 complement(1148653..1149078) 1 NC_007880.1 regulatory protein 1149078 3951300 FTL_1199 Francisella tularensis subsp. holarctica LVS regulatory protein YP_513882.1 1148653 R 376619 CDS YP_513883.1 89256521 3951301 1149226..1150443 1 NC_007880.1 cobalamin (vitamin B12) synthesis protein/P47K family protein 1150443 3951301 FTL_1200 Francisella tularensis subsp. holarctica LVS cobalamin (vitamin B12) synthesis protein/P47K family protein YP_513883.1 1149226 D 376619 CDS YP_513884.1 89256522 3951302 1150446..1151192 1 NC_007880.1 ZIP metal transporter family protein 1151192 3951302 FTL_1201 Francisella tularensis subsp. holarctica LVS ZIP metal transporter family protein YP_513884.1 1150446 D 376619 CDS YP_513885.1 89256523 3951303 complement(1151214..1152203) 1 NC_007880.1 hypothetical protein 1152203 3951303 FTL_1202 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513885.1 1151214 R 376619 CDS YP_513886.1 89256524 3951304 complement(1152371..1153801) 1 NC_007880.1 cardiolipin synthetase 1153801 3951304 FTL_1203 Francisella tularensis subsp. holarctica LVS cardiolipin synthetase YP_513886.1 1152371 R 376619 CDS YP_513887.1 89256525 3951305 complement(1153893..1155320) 1 NC_007880.1 cardiolipin synthetase 1155320 3951305 FTL_1204 Francisella tularensis subsp. holarctica LVS cardiolipin synthetase YP_513887.1 1153893 R 376619 CDS YP_513888.1 89256526 3951306 complement(1155463..1155888) 1 NC_007880.1 hypothetical protein 1155888 3951306 FTL_1205 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513888.1 1155463 R 376619 CDS YP_513889.1 89256527 3951307 complement(1156139..1156597) 1 NC_007880.1 major facilitator transporter 1156597 3951307 FTL_1206 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_513889.1 1156139 R 376619 CDS YP_513890.1 89256528 3951308 1156701..1157561 1 NC_007880.1 MRP like protein 1157561 3951308 FTL_1207 Francisella tularensis subsp. holarctica LVS MRP like protein YP_513890.1 1156701 D 376619 CDS YP_513891.1 89256529 3951309 1157573..1158139 1 NC_007880.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1158139 dcd 3951309 dcd Francisella tularensis subsp. holarctica LVS deoxycytidine triphosphate deaminase YP_513891.1 1157573 D 376619 CDS YP_513892.1 89256530 3951310 complement(1158146..1158844) 1 NC_007880.1 hypothetical protein 1158844 3951310 FTL_1209 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513892.1 1158146 R 376619 CDS YP_513893.1 89256531 3951311 complement(1158893..1159336) 1 NC_007880.1 hypothetical protein 1159336 3951311 FTL_1210 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513893.1 1158893 R 376619 CDS YP_513894.1 89256532 3951312 complement(1159397..1159972) 1 NC_007880.1 lipoprotein 1159972 3951312 FTL_1211 Francisella tularensis subsp. holarctica LVS lipoprotein YP_513894.1 1159397 R 376619 CDS YP_513895.1 89256533 3951526 complement(1159980..1162421) 1 NC_007880.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 1162421 leuS 3951526 leuS Francisella tularensis subsp. holarctica LVS leucyl-tRNA synthetase YP_513895.1 1159980 R 376619 CDS YP_513896.1 89256534 3951527 complement(1162529..1164424) 1 NC_007880.1 hypothetical protein 1164424 3951527 FTL_1213 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513896.1 1162529 R 376619 CDS YP_513897.1 89256535 3951528 complement(1164553..1164810) 1 NC_007880.1 hypothetical protein 1164810 3951528 FTL_1214 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513897.1 1164553 R 376619 CDS YP_513898.1 89256536 3951529 complement(1165224..1165634) 1 NC_007880.1 hypothetical protein 1165634 3951529 FTL_1215 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513898.1 1165224 R 376619 CDS YP_513899.1 89256537 3951530 complement(1165636..1166220) 1 NC_007880.1 hypothetical protein 1166220 3951530 FTL_1216 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513899.1 1165636 R 376619 CDS YP_513900.1 89256538 3951531 complement(1166854..1167225) 1 NC_007880.1 hypothetical protein 1167225 3951531 FTL_1217 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513900.1 1166854 R 376619 CDS YP_513901.1 89256539 3951532 complement(1167906..1168895) 1 NC_007880.1 hypothetical protein 1168895 3951532 FTL_1218 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513901.1 1167906 R 376619 CDS YP_513902.1 89256540 3951533 complement(1169829..1171070) 1 NC_007880.1 hypothetical protein 1171070 3951533 FTL_1219 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513902.1 1169829 R 376619 CDS YP_513903.1 89256541 3951534 1171299..1172666 1 NC_007880.1 amino-acid permease 1172666 3951534 FTL_1220 Francisella tularensis subsp. holarctica LVS amino-acid permease YP_513903.1 1171299 D 376619 CDS YP_513904.1 89256542 3951535 1172718..1173323 1 NC_007880.1 hypothetical protein 1173323 3951535 FTL_1221 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513904.1 1172718 D 376619 CDS YP_513905.1 89256543 3951536 1173327..1173620 1 NC_007880.1 hypothetical protein 1173620 3951536 FTL_1222 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513905.1 1173327 D 376619 CDS YP_513906.1 89256544 3951537 complement(1173745..1174026) 1 NC_007880.1 hypothetical protein 1174026 3951537 FTL_1223 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513906.1 1173745 R 376619 CDS YP_513907.1 89256545 3951538 complement(1174019..1174345) 1 NC_007880.1 thioredoxin 1174345 3951538 FTL_1224 Francisella tularensis subsp. holarctica LVS thioredoxin YP_513907.1 1174019 R 376619 CDS YP_513908.1 89256546 3951539 complement(1174349..1175038) 1 NC_007880.1 hypothetical protein 1175038 3951539 FTL_1225 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513908.1 1174349 R 376619 CDS YP_513909.1 89256547 3951542 complement(1176005..1177150) 1 NC_007880.1 hypothetical protein 1177150 3951542 FTL_1228 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513909.1 1176005 R 376619 CDS YP_513910.1 89256548 3951543 complement(1177163..1177912) 1 NC_007880.1 ABC transporter ATP-binding protein 1177912 3951543 FTL_1229 Francisella tularensis subsp. holarctica LVS ABC transporter ATP-binding protein YP_513910.1 1177163 R 376619 CDS YP_513911.1 89256549 3951544 complement(1177951..1179396) 1 NC_007880.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 1179396 3951544 FTL_1230 Francisella tularensis subsp. holarctica LVS cysteine desulfurase activator complex subunit SufB YP_513911.1 1177951 R 376619 CDS YP_513912.1 89256550 3951545 complement(1179403..1179813) 1 NC_007880.1 hypothetical protein 1179813 3951545 FTL_1231 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513912.1 1179403 R 376619 CDS YP_513913.1 89256551 3951507 1179966..1181339 1 NC_007880.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 1181339 trkA 3951507 trkA Francisella tularensis subsp. holarctica LVS potassium transporter peripheral membrane protein YP_513913.1 1179966 D 376619 CDS YP_513914.1 89256552 3951508 1181398..1182819 1 NC_007880.1 amino acid antiporter 1182819 3951508 FTL_1233 Francisella tularensis subsp. holarctica LVS amino acid antiporter YP_513914.1 1181398 D 376619 CDS YP_513915.1 89256553 3951509 1182824..1183210 1 NC_007880.1 hypothetical protein 1183210 3951509 FTL_1234 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513915.1 1182824 D 376619 CDS YP_513916.1 89256554 3951511 complement(1183781..1183999) 1 NC_007880.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1183999 infA 3951511 infA Francisella tularensis subsp. holarctica LVS translation initiation factor IF-1 YP_513916.1 1183781 R 376619 CDS YP_513917.1 89256555 3951512 1184159..1184998 1 NC_007880.1 hypothetical protein 1184998 3951512 FTL_1237 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513917.1 1184159 D 376619 CDS YP_513918.1 89256556 3951513 1184995..1185261 1 NC_007880.1 hypothetical protein 1185261 3951513 FTL_1238 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513918.1 1184995 D 376619 CDS YP_513919.1 89256557 3951514 1185342..1186718 1 NC_007880.1 signal recognition particle protein, Ffh 1186718 3951514 FTL_1239 Francisella tularensis subsp. holarctica LVS signal recognition particle protein, Ffh YP_513919.1 1185342 D 376619 CDS YP_513920.1 89256558 3951515 1186750..1187862 1 NC_007880.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1187862 3951515 FTL_1240 Francisella tularensis subsp. holarctica LVS phospho-2-dehydro-3-deoxyheptonate aldolase YP_513920.1 1186750 D 376619 CDS YP_513921.1 89256559 3952480 complement(join(1188050..1188604,1188604..1188930)) 1 NC_007880.1 transposase 1188930 isftu1 3952480 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513921.1 1188050 R 376619 CDS YP_513922.1 89256560 3951516 complement(1188954..1189187) 1 NC_007880.1 ThiJ/PfpI family protein 1189187 3951516 FTL_1242 Francisella tularensis subsp. holarctica LVS ThiJ/PfpI family protein YP_513922.1 1188954 R 376619 CDS YP_513923.1 89256561 3951517 complement(1189178..1189510) 1 NC_007880.1 hypothetical protein 1189510 3951517 FTL_1243 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513923.1 1189178 R 376619 CDS YP_513924.1 89256562 3951518 1189794..1190582 1 NC_007880.1 exodeoxyribonuclease III 1190582 3951518 FTL_1244 Francisella tularensis subsp. holarctica LVS exodeoxyribonuclease III YP_513924.1 1189794 D 376619 CDS YP_513925.1 89256563 3951519 1190603..1191310 1 NC_007880.1 short chain dehydrogenase 1191310 3951519 FTL_1245 Francisella tularensis subsp. holarctica LVS short chain dehydrogenase YP_513925.1 1190603 D 376619 CDS YP_513926.1 89256564 3951520 1191313..1191816 1 NC_007880.1 hypothetical protein 1191816 3951520 FTL_1246 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513926.1 1191313 D 376619 CDS YP_513927.1 89256565 3951521 1191816..1192535 1 NC_007880.1 hypothetical protein 1192535 3951521 FTL_1247 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513927.1 1191816 D 376619 CDS YP_513928.1 89256566 3951522 1192573..1193934 1 NC_007880.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 1193934 3951522 FTL_1248 Francisella tularensis subsp. holarctica LVS glutathione reductase YP_513928.1 1192573 D 376619 CDS YP_513929.1 89256567 3951523 1193945..1194265 1 NC_007880.1 hypothetical protein 1194265 3951523 FTL_1249 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513929.1 1193945 D 376619 CDS YP_513930.1 89256568 3951688 1194509..1195174 1 NC_007880.1 transposase 1195174 isftu2 3951688 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513930.1 1194509 D 376619 CDS YP_513931.1 89256569 3951524 1195261..1196802 1 NC_007880.1 proton-dependent oligopeptide transport (POT) family protein 1196802 3951524 FTL_1251 Francisella tularensis subsp. holarctica LVS proton-dependent oligopeptide transport (POT) family protein YP_513931.1 1195261 D 376619 CDS YP_513932.1 89256570 3951525 complement(1196799..1198124) 1 NC_007880.1 ATP-dependent RNA helicase RhlE 1198124 3951525 FTL_1252 Francisella tularensis subsp. holarctica LVS ATP-dependent RNA helicase RhlE YP_513932.1 1196799 R 376619 CDS YP_513933.1 89256571 3952074 1198254..1198871 1 NC_007880.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 1198871 folE 3952074 folE Francisella tularensis subsp. holarctica LVS GTP cyclohydrolase I YP_513933.1 1198254 D 376619 CDS YP_513934.1 89256572 3952079 1201268..1202272 1 NC_007880.1 aldo/keto reductase 1202272 3952079 FTL_1258 Francisella tularensis subsp. holarctica LVS aldo/keto reductase YP_513934.1 1201268 D 376619 CDS YP_513935.1 89256573 3952082 complement(1203492..1204046) 1 NC_007880.1 anthranilate synthase component II 1204046 3952082 FTL_1261 Francisella tularensis subsp. holarctica LVS anthranilate synthase component II YP_513935.1 1203492 R 376619 CDS YP_513936.1 89256574 3952083 complement(1204048..1205811) 1 NC_007880.1 chorismate binding family protein 1205811 3952083 FTL_1262 Francisella tularensis subsp. holarctica LVS chorismate binding family protein YP_513936.1 1204048 R 376619 CDS YP_513937.1 89256575 3952084 complement(1205804..1207174) 1 NC_007880.1 AMP-binding family protein 1207174 3952084 FTL_1263 Francisella tularensis subsp. holarctica LVS AMP-binding family protein YP_513937.1 1205804 R 376619 CDS YP_513938.1 89256576 3952085 1207256..1207609 1 NC_007880.1 dihydroneopterin aldolase 1207609 3952085 FTL_1264 Francisella tularensis subsp. holarctica LVS dihydroneopterin aldolase YP_513938.1 1207256 D 376619 CDS YP_513939.1 89256577 3952086 1207611..1208876 1 NC_007880.1 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 1208876 3952086 FTL_1265 Francisella tularensis subsp. holarctica LVS 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_513939.1 1207611 D 376619 CDS YP_513940.1 89256578 3952087 1208889..1209809 1 NC_007880.1 lipase/esterase 1209809 3952087 FTL_1266 Francisella tularensis subsp. holarctica LVS lipase/esterase YP_513940.1 1208889 D 376619 CDS YP_513941.1 89256579 3952088 1209825..1210325 1 NC_007880.1 hypothetical protein 1210325 3952088 FTL_1267 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513941.1 1209825 D 376619 CDS YP_513942.1 89256580 3952092 complement(1211487..1212773) 1 NC_007880.1 adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1212773 3952092 FTL_1271 Francisella tularensis subsp. holarctica LVS adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_513942.1 1211487 R 376619 CDS YP_513943.1 89256581 3952093 1212864..1213805 1 NC_007880.1 biotin synthase 1213805 3952093 FTL_1272 Francisella tularensis subsp. holarctica LVS biotin synthase YP_513943.1 1212864 D 376619 CDS YP_513944.1 89256582 3951957 1213799..1214926 1 NC_007880.1 8-amino-7-oxononanoate synthase 1214926 3951957 FTL_1273 Francisella tularensis subsp. holarctica LVS 8-amino-7-oxononanoate synthase YP_513944.1 1213799 D 376619 CDS YP_513945.1 89256583 3951958 1214904..1215641 1 NC_007880.1 biotin synthesis protein BioC 1215641 3951958 FTL_1274 Francisella tularensis subsp. holarctica LVS biotin synthesis protein BioC YP_513945.1 1214904 D 376619 CDS YP_513946.1 89256584 3951959 1215645..1216304 1 NC_007880.1 dethiobiotin synthetase 1216304 3951959 FTL_1275 Francisella tularensis subsp. holarctica LVS dethiobiotin synthetase YP_513946.1 1215645 D 376619 CDS YP_513947.1 89256585 3951960 complement(1216412..1217227) 1 NC_007880.1 bifunctional biotin operon repressor/biotin synthetase BirA 1217227 3951960 FTL_1276 Francisella tularensis subsp. holarctica LVS bifunctional biotin operon repressor/biotin synthetase BirA YP_513947.1 1216412 R 376619 CDS YP_513948.1 89256586 3951961 complement(1217250..1218134) 1 NC_007880.1 ROK family protein 1218134 3951961 FTL_1277 Francisella tularensis subsp. holarctica LVS ROK family protein YP_513948.1 1217250 R 376619 CDS YP_513949.1 89256587 3951962 complement(1218136..1219395) 1 NC_007880.1 major facilitator transporter 1219395 3951962 FTL_1278 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_513949.1 1218136 R 376619 CDS YP_513950.1 89256588 3951963 1219845..1220399 1 NC_007880.1 acetoacetate decarboxylase, fragment 1220399 3951963 FTL_1279 Francisella tularensis subsp. holarctica LVS acetoacetate decarboxylase, fragment YP_513950.1 1219845 D 376619 CDS YP_513951.1 89256589 3951964 1220421..1220603 1 NC_007880.1 short-chain dehydrogenase 1220603 3951964 FTL_1280 Francisella tularensis subsp. holarctica LVS short-chain dehydrogenase YP_513951.1 1220421 D 376619 CDS YP_513952.1 89256590 3951965 1220604..1221203 1 NC_007880.1 hypothetical protein 1221203 3951965 FTL_1281 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513952.1 1220604 D 376619 CDS YP_513953.1 89256591 3951966 1221264..1222931 1 NC_007880.1 beta-glucosidase 1222931 3951966 FTL_1282 Francisella tularensis subsp. holarctica LVS beta-glucosidase YP_513953.1 1221264 D 376619 CDS YP_513954.1 89256592 3951967 complement(1222952..1224247) 1 NC_007880.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 1224247 3951967 FTL_1283 Francisella tularensis subsp. holarctica LVS glutamate-1-semialdehyde aminotransferase YP_513954.1 1222952 R 376619 CDS YP_513955.1 89256593 3951968 complement(1224237..1225211) 1 NC_007880.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 1225211 3951968 FTL_1284 Francisella tularensis subsp. holarctica LVS glutathione synthetase YP_513955.1 1224237 R 376619 CDS YP_513956.1 89256594 3951969 complement(1225215..1226156) 1 NC_007880.1 methionyl-tRNA formyltransferase 1226156 3951969 FTL_1285 Francisella tularensis subsp. holarctica LVS methionyl-tRNA formyltransferase YP_513956.1 1225215 R 376619 CDS YP_513957.1 89256595 3951970 complement(1226161..1226559) 1 NC_007880.1 hypothetical protein 1226559 3951970 FTL_1286 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513957.1 1226161 R 376619 CDS YP_513958.1 89256596 3951971 complement(1226661..1228814) 1 NC_007880.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1228814 rlmL 3951971 rlmL Francisella tularensis subsp. holarctica LVS 23S rRNA m(2)G2445 methyltransferase YP_513958.1 1226661 R 376619 CDS YP_513959.1 89256597 3951972 complement(1228889..1229443) 1 NC_007880.1 fatty acid hydroxylase 1229443 3951972 FTL_1288 Francisella tularensis subsp. holarctica LVS fatty acid hydroxylase YP_513959.1 1228889 R 376619 CDS YP_513960.1 89256598 3951973 complement(1230409..1230903) 1 NC_007880.1 hypothetical protein 1230903 3951973 FTL_1289 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513960.1 1230409 R 376619 CDS YP_513961.1 89256599 3952481 complement(join(1230875..1231429,1231429..1231755)) 1 NC_007880.1 transposase 1231755 isftu1 3952481 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513961.1 1230875 R 376619 CDS YP_513962.1 89256600 3951974 1231849..1232166 1 NC_007880.1 hypothetical protein 1232166 3951974 FTL_1291 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513962.1 1231849 D 376619 CDS YP_513963.1 89256601 3951975 1232299..1232967 1 NC_007880.1 hypothetical protein 1232967 3951975 FTL_1292 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513963.1 1232299 D 376619 CDS YP_513964.1 89256602 3952286 1233021..1233491 1 NC_007880.1 hypothetical protein 1233491 3952286 FTL_1293 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513964.1 1233021 D 376619 CDS YP_513965.1 89256603 3952287 1233628..1234452 1 NC_007880.1 short-chain dehydrogenase 1234452 3952287 FTL_1294 Francisella tularensis subsp. holarctica LVS short-chain dehydrogenase YP_513965.1 1233628 D 376619 CDS YP_513966.1 89256604 3952288 complement(1234474..1235253) 1 NC_007880.1 amino acid transporter 1235253 3952288 FTL_1295 Francisella tularensis subsp. holarctica LVS amino acid transporter YP_513966.1 1234474 R 376619 CDS YP_513967.1 89256605 3952289 complement(1235301..1235801) 1 NC_007880.1 amino acid antiporter 1235801 3952289 FTL_1296 Francisella tularensis subsp. holarctica LVS amino acid antiporter YP_513967.1 1235301 R 376619 CDS YP_513968.1 89256606 3952290 complement(1236059..1236931) 1 NC_007880.1 hypothetical protein 1236931 3952290 FTL_1297 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513968.1 1236059 R 376619 CDS YP_513969.1 89256607 3952113 join(1237099..1237423,1237423..1237979) 1 NC_007880.1 transposase 1237979 isftu1 3952113 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513969.1 1237099 D 376619 CDS YP_513970.1 89256608 3952291 complement(1238007..1238456) 1 NC_007880.1 hypothetical protein 1238456 3952291 FTL_1299 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513970.1 1238007 R 376619 CDS YP_513971.1 89256609 3952292 complement(1238465..1238806) 1 NC_007880.1 hypothetical protein 1238806 3952292 FTL_1300 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513971.1 1238465 R 376619 CDS YP_513972.1 89256610 3951689 1239087..1239725 1 NC_007880.1 transposase 1239725 isftu2 3951689 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_513972.1 1239087 D 376619 CDS YP_513973.1 89256611 3952293 1239801..1240532 1 NC_007880.1 phenol hydroxylase 1240532 3952293 FTL_1302 Francisella tularensis subsp. holarctica LVS phenol hydroxylase YP_513973.1 1239801 D 376619 CDS YP_513974.2 161353780 3952294 1240654..1240872 1 NC_007880.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1240872 rpmE 3952294 rpmE Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L31 YP_513974.2 1240654 D 376619 CDS YP_513975.1 89256613 3952295 complement(1241081..1242586) 1 NC_007880.1 glutamate--cysteine ligase 1242586 3952295 FTL_1304 Francisella tularensis subsp. holarctica LVS glutamate--cysteine ligase YP_513975.1 1241081 R 376619 CDS YP_513976.1 89256614 3952296 complement(1242639..1244180) 1 NC_007880.1 virulence factor MviN 1244180 3952296 FTL_1305 Francisella tularensis subsp. holarctica LVS virulence factor MviN YP_513976.1 1242639 R 376619 CDS YP_513977.1 89256615 3952297 complement(1244203..1245264) 1 NC_007880.1 hypothetical protein 1245264 3952297 FTL_1306 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513977.1 1244203 R 376619 CDS YP_513978.1 89256616 3952298 complement(1245347..1245724) 1 NC_007880.1 nucleotide-binding protein, yjeE 1245724 3952298 FTL_1307 Francisella tularensis subsp. holarctica LVS nucleotide-binding protein, yjeE YP_513978.1 1245347 R 376619 CDS YP_513979.1 89256617 3952299 complement(1245735..1246916) 1 NC_007880.1 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase 1246916 3952299 FTL_1308 Francisella tularensis subsp. holarctica LVS bifunctional folylpolyglutamate synthase/ dihydrofolate synthase YP_513979.1 1245735 R 376619 CDS YP_513980.1 89256618 3952300 complement(1246931..1247833) 1 NC_007880.1 Acetyl-CoA carboxylase beta subunit 1247833 3952300 FTL_1309 Francisella tularensis subsp. holarctica LVS Acetyl-CoA carboxylase beta subunit YP_513980.1 1246931 R 376619 CDS YP_513981.1 89256619 3952301 complement(1247875..1248297) 1 NC_007880.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1248297 ndk 3952301 ndk Francisella tularensis subsp. holarctica LVS nucleoside diphosphate kinase YP_513981.1 1247875 R 376619 CDS YP_513982.1 89256620 3952302 complement(1248370..1250010) 1 NC_007880.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1250010 pyrG 3952302 pyrG Francisella tularensis subsp. holarctica LVS CTP synthetase YP_513982.1 1248370 R 376619 CDS YP_513983.1 89256621 3952303 1250323..1251177 1 NC_007880.1 S-transferase 1251177 3952303 FTL_1312 Francisella tularensis subsp. holarctica LVS S-transferase YP_513983.1 1250323 D 376619 CDS YP_513984.1 89256622 3952304 1251093..1251827 1 NC_007880.1 short-chain fatty acids transporter 1251827 3952304 FTL_1313 Francisella tularensis subsp. holarctica LVS short-chain fatty acids transporter YP_513984.1 1251093 D 376619 CDS YP_513985.1 89256623 3952305 complement(1252110..1253018) 1 NC_007880.1 hypothetical protein 1253018 3952305 FTL_1314 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513985.1 1252110 R 376619 CDS YP_513986.1 89256624 3952597 complement(1253064..1253498) 1 NC_007880.1 hypothetical protein 1253498 3952597 FTL_1315 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513986.1 1253064 R 376619 CDS YP_513987.1 89256625 3952114 join(1253489..1253813,1253813..1254369) 1 NC_007880.1 transposase 1254369 isftu1 3952114 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_513987.1 1253489 D 376619 CDS YP_513988.1 89256626 3952598 complement(1254565..1255560) 1 NC_007880.1 hypothetical protein 1255560 3952598 FTL_1317 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513988.1 1254565 R 376619 CDS YP_513989.1 89256627 3952599 1255917..1256432 1 NC_007880.1 transposase 1256432 3952599 FTL_1319 Francisella tularensis subsp. holarctica LVS transposase YP_513989.1 1255917 D 376619 CDS YP_513990.1 89256628 3952600 complement(1256815..1257387) 1 NC_007880.1 hypothetical protein 1257387 3952600 FTL_1320 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513990.1 1256815 R 376619 CDS YP_513991.1 89256629 3952601 complement(1257374..1257667) 1 NC_007880.1 hypothetical protein 1257667 3952601 FTL_1321 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513991.1 1257374 R 376619 CDS YP_513992.1 89256630 3952606 complement(1261927..1262403) 1 NC_007880.1 hypothetical protein 1262403 3952606 FTL_1326 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513992.1 1261927 R 376619 CDS YP_513993.1 89256631 3952607 complement(1262508..1263689) 1 NC_007880.1 hypothetical protein 1263689 3952607 FTL_1327 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513993.1 1262508 R 376619 CDS YP_513994.1 89256632 3952608 complement(1264352..1265530) 1 NC_007880.1 outer membrane associated protein 1265530 3952608 FTL_1328 Francisella tularensis subsp. holarctica LVS outer membrane associated protein YP_513994.1 1264352 R 376619 CDS YP_513995.1 89256633 3952609 complement(1265640..1265885) 1 NC_007880.1 ferredoxin 1265885 3952609 FTL_1329 Francisella tularensis subsp. holarctica LVS ferredoxin YP_513995.1 1265640 R 376619 CDS YP_513996.1 89256634 3952610 complement(1265890..1266378) 1 NC_007880.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1266378 coaD 3952610 coaD Francisella tularensis subsp. holarctica LVS phosphopantetheine adenylyltransferase YP_513996.1 1265890 R 376619 CDS YP_513997.1 89256635 3952611 complement(1266390..1266941) 1 NC_007880.1 hypothetical protein 1266941 3952611 FTL_1331 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_513997.1 1266390 R 376619 CDS YP_513998.1 89256636 3952612 complement(1266955..1267311) 1 NC_007880.1 hesB family protein 1267311 3952612 FTL_1332 Francisella tularensis subsp. holarctica LVS hesB family protein YP_513998.1 1266955 R 376619 CDS YP_513999.1 89256637 3952613 complement(1267332..1268555) 1 NC_007880.1 selenocysteine lyase 1268555 3952613 FTL_1333 Francisella tularensis subsp. holarctica LVS selenocysteine lyase YP_513999.1 1267332 R 376619 CDS YP_514000.1 89256638 3952614 complement(1268658..1270031) 1 NC_007880.1 L-serine dehydratase 1 1270031 3952614 FTL_1334 Francisella tularensis subsp. holarctica LVS L-serine dehydratase 1 YP_514000.1 1268658 R 376619 CDS YP_514001.1 89256639 3952615 complement(1270087..1270755) 1 NC_007880.1 hypothetical protein 1270755 3952615 FTL_1335 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514001.1 1270087 R 376619 CDS YP_514002.1 89256640 3951759 complement(1270781..1271623) 1 NC_007880.1 prephenate dehydratase 1271623 3951759 FTL_1336 Francisella tularensis subsp. holarctica LVS prephenate dehydratase YP_514002.1 1270781 R 376619 CDS YP_514003.1 89256641 3951761 complement(1273399..1274496) 1 NC_007880.1 alanine racemase 1274496 3951761 FTL_1338 Francisella tularensis subsp. holarctica LVS alanine racemase YP_514003.1 1273399 R 376619 CDS YP_514004.1 89256642 3951762 complement(1274601..1275971) 1 NC_007880.1 proton-dependent oligopeptide transport (POT) family protein 1275971 3951762 FTL_1339 Francisella tularensis subsp. holarctica LVS proton-dependent oligopeptide transport (POT) family protein YP_514004.1 1274601 R 376619 CDS YP_514005.1 89256643 3951763 complement(1276096..1276803) 1 NC_007880.1 hypothetical protein 1276803 3951763 FTL_1340 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514005.1 1276096 R 376619 CDS YP_514006.1 89256644 3951764 complement(1276815..1277213) 1 NC_007880.1 hypothetical protein 1277213 3951764 FTL_1341 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514006.1 1276815 R 376619 CDS YP_514007.1 89256645 3951765 1277293..1278315 1 NC_007880.1 hypothetical protein 1278315 3951765 FTL_1342 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514007.1 1277293 D 376619 CDS YP_514008.1 89256646 3951766 complement(1278304..1278609) 1 NC_007880.1 hypothetical protein 1278609 3951766 FTL_1343 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514008.1 1278304 R 376619 CDS YP_514009.1 89256647 3951767 complement(1278606..1278953) 1 NC_007880.1 hypothetical protein 1278953 3951767 FTL_1344 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514009.1 1278606 R 376619 CDS YP_514010.1 89256648 3951770 complement(1281238..1281408) 1 NC_007880.1 hypothetical protein 1281408 3951770 FTL_1347 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514010.1 1281238 R 376619 CDS YP_514011.1 89256649 3951771 1281701..1282513 1 NC_007880.1 transposase 1282513 3951771 FTL_1348 Francisella tularensis subsp. holarctica LVS transposase YP_514011.1 1281701 D 376619 CDS YP_514012.1 89256650 3952115 complement(join(1282297..1282797,1282797..1283123)) 1 NC_007880.1 transposase 1283123 isftu1 3952115 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514012.1 1282297 R 376619 CDS YP_514013.1 89256651 3951772 complement(1283273..1285357) 1 NC_007880.1 glycyl-tRNA synthetase subunit beta 1285357 3951772 FTL_1350 Francisella tularensis subsp. holarctica LVS glycyl-tRNA synthetase subunit beta YP_514013.1 1283273 R 376619 CDS YP_514014.1 89256652 3951773 1285550..1286224 1 NC_007880.1 TatD related DNAse family protein 1286224 3951773 FTL_1351 Francisella tularensis subsp. holarctica LVS TatD related DNAse family protein YP_514014.1 1285550 D 376619 CDS YP_514015.1 89256653 3951774 1286228..1287277 1 NC_007880.1 DNA replication and repair protein RecF 1287277 3951774 FTL_1352 Francisella tularensis subsp. holarctica LVS DNA replication and repair protein RecF YP_514015.1 1286228 D 376619 CDS YP_514016.1 89256654 3951775 1287299..1287592 1 NC_007880.1 hypothetical protein 1287592 3951775 FTL_1353 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514016.1 1287299 D 376619 CDS YP_514017.1 89256655 3951776 complement(1287886..1288803) 1 NC_007880.1 hypothetical protein 1288803 3951776 FTL_1354 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514017.1 1287886 R 376619 CDS YP_514018.1 89256656 3952248 complement(1290276..1291139) 1 NC_007880.1 UTP--glucose-1-phosphate uridylyltransferase 1291139 3952248 FTL_1357 Francisella tularensis subsp. holarctica LVS UTP--glucose-1-phosphate uridylyltransferase YP_514018.1 1290276 R 376619 CDS YP_514019.1 89256657 3952249 complement(1291156..1292295) 1 NC_007880.1 cation-efflux family protein 1292295 3952249 FTL_1358 Francisella tularensis subsp. holarctica LVS cation-efflux family protein YP_514019.1 1291156 R 376619 CDS YP_514020.1 89256658 3952250 complement(1292386..1292955) 1 NC_007880.1 hypothetical protein 1292955 3952250 FTL_1359 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514020.1 1292386 R 376619 CDS YP_514021.1 89256659 3952251 complement(1293823..1294023) 1 NC_007880.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1294023 rpsU 3952251 rpsU Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S21 YP_514021.1 1293823 R 376619 CDS YP_514022.1 89256660 3952252 1294796..1294999 1 NC_007880.1 cold shock protein 1294999 3952252 FTL_1361 Francisella tularensis subsp. holarctica LVS cold shock protein YP_514022.1 1294796 D 376619 CDS YP_514023.1 89256661 3952253 complement(1295070..1296056) 1 NC_007880.1 hypothetical protein 1296056 3952253 FTL_1362 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514023.1 1295070 R 376619 CDS YP_514024.1 89256662 3952254 1296262..1297260 1 NC_007880.1 hypothetical protein 1297260 3952254 FTL_1363 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514024.1 1296262 D 376619 CDS YP_514025.1 89256663 3952255 complement(1297284..1298003) 1 NC_007880.1 hypothetical protein 1298003 3952255 FTL_1364 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514025.1 1297284 R 376619 CDS YP_514026.1 89256664 3952256 1298404..1298823 1 NC_007880.1 hypothetical protein 1298823 3952256 FTL_1365 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514026.1 1298404 D 376619 CDS YP_514027.1 89256665 3952257 1298928..1299245 1 NC_007880.1 membrane fusion protein 1299245 3952257 FTL_1366 Francisella tularensis subsp. holarctica LVS membrane fusion protein YP_514027.1 1298928 D 376619 CDS YP_514028.1 89256666 3952258 1299242..1300045 1 NC_007880.1 hypothetical protein 1300045 3952258 FTL_1367 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514028.1 1299242 D 376619 CDS YP_514029.1 89256667 3952259 1300042..1300608 1 NC_007880.1 hypothetical protein 1300608 3952259 FTL_1368 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514029.1 1300042 D 376619 CDS YP_514030.1 89256668 3952116 complement(join(1300731..1301285,1301285..1301611)) 1 NC_007880.1 transposase 1301611 isftu1 3952116 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514030.1 1300731 R 376619 CDS YP_514031.1 89256669 3952260 complement(1301987..1302802) 1 NC_007880.1 hypothetical protein 1302802 3952260 FTL_1370 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514031.1 1301987 R 376619 CDS YP_514032.1 89256670 3952261 complement(1303481..1304344) 1 NC_007880.1 hypothetical protein 1304344 3952261 FTL_1371 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514032.1 1303481 R 376619 CDS YP_514033.1 89256671 3952262 complement(1304334..1305683) 1 NC_007880.1 lipoprotein 1305683 3952262 FTL_1372 Francisella tularensis subsp. holarctica LVS lipoprotein YP_514033.1 1304334 R 376619 CDS YP_514034.1 89256672 3952263 1306156..1306653 1 NC_007880.1 hypothetical protein 1306653 3952263 FTL_1373 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514034.1 1306156 D 376619 CDS YP_514035.1 89256673 3952264 1306861..1308687 1 NC_007880.1 organic solvent tolerance protein 1308687 3952264 FTL_1374 Francisella tularensis subsp. holarctica LVS organic solvent tolerance protein YP_514035.1 1306861 D 376619 CDS YP_514036.1 89256674 3952265 1308905..1309273 1 NC_007880.1 heat shock protein 15 (HSP15) 1309273 3952265 FTL_1375 Francisella tularensis subsp. holarctica LVS heat shock protein 15 (HSP15) YP_514036.1 1308905 D 376619 CDS YP_514037.1 89256675 3952266 complement(1309308..1310801) 1 NC_007880.1 carbohydrate kinase family protein (YjeF-related protein) 1310801 3952266 FTL_1376 Francisella tularensis subsp. holarctica LVS carbohydrate kinase family protein (YjeF-related protein) YP_514037.1 1309308 R 376619 CDS YP_514038.1 89256676 3952702 complement(1311108..1311755) 1 NC_007880.1 hypothetical protein 1311755 3952702 FTL_1377 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514038.1 1311108 R 376619 CDS YP_514039.1 89256677 3952708 complement(1314045..1314515) 1 NC_007880.1 glutathione peroxidase 1314515 3952708 FTL_1383 Francisella tularensis subsp. holarctica LVS glutathione peroxidase YP_514039.1 1314045 R 376619 CDS YP_514040.1 89256678 3952709 complement(1314544..1314891) 1 NC_007880.1 hypothetical protein 1314891 3952709 FTL_1384 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514040.1 1314544 R 376619 CDS YP_514041.1 89256679 3952710 1314988..1315434 1 NC_007880.1 hypothetical protein 1315434 3952710 FTL_1385 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514041.1 1314988 D 376619 CDS YP_514042.1 89256680 3951691 complement(1315609..1316265) 1 NC_007880.1 transposase 1316265 isftu2 3951691 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_514042.1 1315609 R 376619 CDS YP_514043.1 89256681 3952712 complement(1317524..1319011) 1 NC_007880.1 L-aspartate oxidase 1319011 3952712 FTL_1388 Francisella tularensis subsp. holarctica LVS L-aspartate oxidase YP_514043.1 1317524 R 376619 CDS YP_514044.1 89256682 3952713 complement(1319014..1319877) 1 NC_007880.1 nicotinate-nucleotide pyrophosphorylase 1319877 3952713 FTL_1389 Francisella tularensis subsp. holarctica LVS nicotinate-nucleotide pyrophosphorylase YP_514044.1 1319014 R 376619 CDS YP_514045.1 89256683 3952714 complement(1319886..1320911) 1 NC_007880.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 1320911 3952714 FTL_1390 Francisella tularensis subsp. holarctica LVS quinolinate synthetase YP_514045.1 1319886 R 376619 CDS YP_514046.1 89256684 3952715 complement(1320932..1321504) 1 NC_007880.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1321504 gmk 3952715 gmk Francisella tularensis subsp. holarctica LVS guanylate kinase YP_514046.1 1320932 R 376619 CDS YP_514047.1 89256685 3952716 complement(1321621..1323330) 1 NC_007880.1 cold-shock DEAD-box protein A 1323330 3952716 FTL_1392 Francisella tularensis subsp. holarctica LVS cold-shock DEAD-box protein A YP_514047.1 1321621 R 376619 CDS YP_514048.1 89256686 3952717 complement(1323365..1323643) 1 NC_007880.1 peptidyl-prolyl cis-trans isomerase 1323643 3952717 FTL_1393 Francisella tularensis subsp. holarctica LVS peptidyl-prolyl cis-trans isomerase YP_514048.1 1323365 R 376619 CDS YP_514049.1 89256687 3952718 complement(1323738..1325132) 1 NC_007880.1 major facilitator superfamily galactose-proton symporter 1325132 3952718 FTL_1394 Francisella tularensis subsp. holarctica LVS major facilitator superfamily galactose-proton symporter YP_514049.1 1323738 R 376619 CDS YP_514050.1 89256688 3952719 complement(1325164..1326543) 1 NC_007880.1 major facilitator superfamily galactose-proton symporter 1326543 3952719 FTL_1395 Francisella tularensis subsp. holarctica LVS major facilitator superfamily galactose-proton symporter YP_514050.1 1325164 R 376619 CDS YP_514051.1 89256689 3952720 1326634..1327659 1 NC_007880.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 1327659 3952720 FTL_1396 Francisella tularensis subsp. holarctica LVS galactose-1-phosphate uridylyltransferase YP_514051.1 1326634 D 376619 CDS YP_514052.1 89256690 3952721 1327662..1328810 1 NC_007880.1 galactokinase 1328810 3952721 FTL_1397 Francisella tularensis subsp. holarctica LVS galactokinase YP_514052.1 1327662 D 376619 CDS YP_514053.1 89256691 3952385 complement(1328807..1329202) 1 NC_007880.1 hypothetical protein 1329202 3952385 FTL_1398 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514053.1 1328807 R 376619 CDS YP_514054.1 89256692 3952386 complement(1329195..1329947) 1 NC_007880.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1329947 3952386 FTL_1399 Francisella tularensis subsp. holarctica LVS 3-deoxy-manno-octulosonate cytidylyltransferase YP_514054.1 1329195 R 376619 CDS YP_514055.1 89256693 3952387 complement(1329940..1330188) 1 NC_007880.1 hypothetical protein 1330188 3952387 FTL_1400 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514055.1 1329940 R 376619 CDS YP_514056.1 89256694 3952388 complement(1330513..1330785) 1 NC_007880.1 hypothetical protein 1330785 3952388 FTL_1401 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514056.1 1330513 R 376619 CDS YP_514057.1 89256695 3952117 complement(join(1330757..1331311,1331311..1331637)) 1 NC_007880.1 transposase 1331637 isftu1 3952117 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514057.1 1330757 R 376619 CDS YP_514058.1 89256696 3952389 complement(1331929..1332564) 1 NC_007880.1 hypothetical protein 1332564 3952389 FTL_1403 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514058.1 1331929 R 376619 CDS YP_514059.1 89256697 3952390 complement(1332675..1333031) 1 NC_007880.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1333031 rplT 3952390 rplT Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L20 YP_514059.1 1332675 R 376619 CDS YP_514060.1 89256698 3952391 complement(1333067..1333264) 1 NC_007880.1 50S ribosomal protein L35 1333264 rpmI 3952391 rpmI Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L35 YP_514060.1 1333067 R 376619 CDS YP_514061.1 89256699 3952392 complement(1333307..1333774) 1 NC_007880.1 translation initiation factor IF-3 1333774 3952392 FTL_1406 Francisella tularensis subsp. holarctica LVS translation initiation factor IF-3 YP_514061.1 1333307 R 376619 CDS YP_514062.1 89256700 3952393 complement(1333850..1335754) 1 NC_007880.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1335754 thrS 3952393 thrS Francisella tularensis subsp. holarctica LVS threonyl-tRNA synthetase YP_514062.1 1333850 R 376619 CDS YP_514063.1 89256701 3952394 1336260..1337984 1 NC_007880.1 chitin binding protein 1337984 3952394 FTL_1408 Francisella tularensis subsp. holarctica LVS chitin binding protein YP_514063.1 1336260 D 376619 CDS YP_514064.1 89256702 3952395 complement(1338357..1338737) 1 NC_007880.1 glycine cleavage system protein H 1338737 3952395 FTL_1409 Francisella tularensis subsp. holarctica LVS glycine cleavage system protein H YP_514064.1 1338357 R 376619 CDS YP_514065.1 89256703 3952396 1338841..1339956 1 NC_007880.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 1339956 murG 3952396 murG Francisella tularensis subsp. holarctica LVS undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_514065.1 1338841 D 376619 CDS YP_514066.1 89256704 3952397 1339966..1340304 1 NC_007880.1 hypothetical protein 1340304 3952397 FTL_1411 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514066.1 1339966 D 376619 CDS YP_514067.1 89256705 3952398 1340304..1340906 1 NC_007880.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1340906 3952398 FTL_1412 Francisella tularensis subsp. holarctica LVS recombination protein RecR YP_514067.1 1340304 D 376619 CDS YP_514068.1 89256706 3952399 complement(1340914..1343028) 1 NC_007880.1 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase/(p)ppGpp synthase 1343028 3952399 FTL_1413 Francisella tularensis subsp. holarctica LVS guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase/(p)ppGpp synthase YP_514068.1 1340914 R 376619 CDS YP_514069.1 89256707 3952400 complement(1343097..1344308) 1 NC_007880.1 hypothetical protein 1344308 3952400 FTL_1414 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514069.1 1343097 R 376619 CDS YP_514070.1 89256708 3952401 complement(1344310..1344774) 1 NC_007880.1 capsule biosynthesis protein CapC 1344774 3952401 FTL_1415 Francisella tularensis subsp. holarctica LVS capsule biosynthesis protein CapC YP_514070.1 1344310 R 376619 CDS YP_514071.1 89256709 3952402 complement(1344799..1346007) 1 NC_007880.1 capsule biosynthesis protein capB 1346007 3952402 FTL_1416 Francisella tularensis subsp. holarctica LVS capsule biosynthesis protein capB YP_514071.1 1344799 R 376619 CDS YP_514072.1 89256710 3952403 complement(1346092..1347348) 1 NC_007880.1 major facilitator transporter 1347348 3952403 FTL_1417 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514072.1 1346092 R 376619 CDS YP_514073.1 89256711 3951643 complement(1348020..1348883) 1 NC_007880.1 asparaginase 1348883 3951643 FTL_1418 Francisella tularensis subsp. holarctica LVS asparaginase YP_514073.1 1348020 R 376619 CDS YP_514074.1 89256712 3951644 complement(1349099..1349917) 1 NC_007880.1 cyanophycinase 1349917 3951644 FTL_1419 Francisella tularensis subsp. holarctica LVS cyanophycinase YP_514074.1 1349099 R 376619 CDS YP_514075.1 89256713 3951645 1350120..1351226 1 NC_007880.1 carbohydrate/purine kinase pfkB family protein 1351226 3951645 FTL_1420 Francisella tularensis subsp. holarctica LVS carbohydrate/purine kinase pfkB family protein YP_514075.1 1350120 D 376619 CDS YP_514076.1 89256714 3951646 complement(1351508..1352170) 1 NC_007880.1 haloacid dehalogenase-like hydrolase family protein 1352170 3951646 FTL_1421 Francisella tularensis subsp. holarctica LVS haloacid dehalogenase-like hydrolase family protein YP_514076.1 1351508 R 376619 CDS YP_514077.1 89256715 3951647 complement(1352189..1353202) 1 NC_007880.1 glycosyl transferases group 1 family protein 1353202 3951647 FTL_1422 Francisella tularensis subsp. holarctica LVS glycosyl transferases group 1 family protein YP_514077.1 1352189 R 376619 CDS YP_514078.1 89256716 3951648 complement(1353205..1354212) 1 NC_007880.1 glycosyl transferase family protein 1354212 3951648 FTL_1423 Francisella tularensis subsp. holarctica LVS glycosyl transferase family protein YP_514078.1 1353205 R 376619 CDS YP_514079.1 89256717 3951649 complement(1354229..1355188) 1 NC_007880.1 glycosyl transferase family protein 1355188 3951649 FTL_1424 Francisella tularensis subsp. holarctica LVS glycosyl transferase family protein YP_514079.1 1354229 R 376619 CDS YP_514080.1 89256718 3951650 complement(1355197..1355958) 1 NC_007880.1 hypothetical protein 1355958 3951650 FTL_1425 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514080.1 1355197 R 376619 CDS YP_514081.1 89256719 3951651 complement(1355962..1356636) 1 NC_007880.1 hypothetical protein 1356636 3951651 FTL_1426 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514081.1 1355962 R 376619 CDS YP_514082.1 89256720 3951652 complement(1356584..1357870) 1 NC_007880.1 hypothetical protein 1357870 3951652 FTL_1427 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514082.1 1356584 R 376619 CDS YP_514083.1 89256721 3951653 complement(1357884..1359566) 1 NC_007880.1 ABC transporter ATP-binding and membrane protein 1359566 3951653 FTL_1428 Francisella tularensis subsp. holarctica LVS ABC transporter ATP-binding and membrane protein YP_514083.1 1357884 R 376619 CDS YP_514084.1 89256722 3951654 complement(1359563..1360792) 1 NC_007880.1 glycosyl transferases group 1 family protein 1360792 3951654 FTL_1429 Francisella tularensis subsp. holarctica LVS glycosyl transferases group 1 family protein YP_514084.1 1359563 R 376619 CDS YP_514085.1 89256723 3951655 complement(1360796..1361815) 1 NC_007880.1 UDP-glucose 4-epimerase 1361815 3951655 FTL_1430 Francisella tularensis subsp. holarctica LVS UDP-glucose 4-epimerase YP_514085.1 1360796 R 376619 CDS YP_514086.1 89256724 3951656 complement(1361808..1363202) 1 NC_007880.1 sugar transferase 1363202 3951656 FTL_1431 Francisella tularensis subsp. holarctica LVS sugar transferase YP_514086.1 1361808 R 376619 CDS YP_514087.1 89256725 3951657 complement(1363183..1363851) 1 NC_007880.1 D-ribulose-phosphate 3-epimerase 1363851 3951657 FTL_1432 Francisella tularensis subsp. holarctica LVS D-ribulose-phosphate 3-epimerase YP_514087.1 1363183 R 376619 CDS YP_514088.1 89256726 3951658 1363988..1364959 1 NC_007880.1 arabinose phosphate isomerase 1364959 3951658 FTL_1433 Francisella tularensis subsp. holarctica LVS arabinose phosphate isomerase YP_514088.1 1363988 D 376619 CDS YP_514089.1 89256727 3951659 complement(1364963..1365553) 1 NC_007880.1 DoxD-like family protein 1365553 3951659 FTL_1434 Francisella tularensis subsp. holarctica LVS DoxD-like family protein YP_514089.1 1364963 R 376619 CDS YP_514090.1 89256728 3951660 complement(1365564..1365986) 1 NC_007880.1 hypothetical protein 1365986 3951660 FTL_1435 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514090.1 1365564 R 376619 CDS YP_514091.1 89256729 3951661 complement(1366022..1366261) 1 NC_007880.1 hypothetical protein 1366261 3951661 FTL_1436 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514091.1 1366022 R 376619 CDS YP_514092.1 89256730 3951662 complement(1366258..1367067) 1 NC_007880.1 hypothetical protein 1367067 3951662 FTL_1437 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514092.1 1366258 R 376619 CDS YP_514093.1 89256731 3952015 complement(1367064..1367393) 1 NC_007880.1 hypothetical protein 1367393 3952015 FTL_1438 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514093.1 1367064 R 376619 CDS YP_514094.1 89256732 3952016 complement(1367405..1367968) 1 NC_007880.1 arylsulfatase 1367968 3952016 FTL_1439 Francisella tularensis subsp. holarctica LVS arylsulfatase YP_514094.1 1367405 R 376619 CDS YP_514095.1 89256733 3952017 complement(1367863..1368366) 1 NC_007880.1 beta-lactamase superfamily hydrolase 1368366 3952017 FTL_1440 Francisella tularensis subsp. holarctica LVS beta-lactamase superfamily hydrolase YP_514095.1 1367863 R 376619 CDS YP_514096.1 89256734 3951692 1368672..1369346 1 NC_007880.1 transposase 1369346 isftu2 3951692 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_514096.1 1368672 D 376619 CDS YP_514097.1 89256735 3952018 complement(1369371..1370153) 1 NC_007880.1 enoyl-[acyl-carrier-protein] reductase (NADH) 1370153 3952018 FTL_1442 Francisella tularensis subsp. holarctica LVS enoyl-[acyl-carrier-protein] reductase (NADH) YP_514097.1 1369371 R 376619 CDS YP_514098.1 89256736 3952019 1370439..1371152 1 NC_007880.1 hypothetical protein 1371152 3952019 FTL_1443 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514098.1 1370439 D 376619 CDS YP_514099.1 89256737 3952020 1371166..1371411 1 NC_007880.1 hypothetical protein 1371411 3952020 FTL_1444 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514099.1 1371166 D 376619 CDS YP_514100.1 89256738 3951693 1371895..1372707 1 NC_007880.1 transposase 1372707 isftu2 3951693 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_514100.1 1371895 D 376619 CDS YP_514101.1 89256739 3952118 complement(join(1372491..1372991,1372991..1373317)) 1 NC_007880.1 transposase 1373317 isftu1 3952118 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514101.1 1372491 R 376619 CDS YP_514102.1 89256740 3952021 complement(1373395..1373769) 1 NC_007880.1 hypothetical protein 1373769 3952021 FTL_1447 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514102.1 1373395 R 376619 CDS YP_514103.1 89256741 3952022 complement(1373836..1375674) 1 NC_007880.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1375674 uvrC 3952022 uvrC Francisella tularensis subsp. holarctica LVS excinuclease ABC subunit C YP_514103.1 1373836 R 376619 CDS YP_514104.1 89256742 3952023 1375783..1376877 1 NC_007880.1 ribonuclease D 1376877 3952023 FTL_1449 Francisella tularensis subsp. holarctica LVS ribonuclease D YP_514104.1 1375783 D 376619 CDS YP_514105.1 89256743 3952024 1376906..1378120 1 NC_007880.1 major facilitator transporter 1378120 3952024 FTL_1450 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514105.1 1376906 D 376619 CDS YP_514106.1 89256744 3952025 complement(1378117..1378494) 1 NC_007880.1 hypothetical protein 1378494 3952025 FTL_1451 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514106.1 1378117 R 376619 CDS YP_514107.1 89256745 3952026 complement(1378881..1379135) 1 NC_007880.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1379135 rpmA 3952026 rpmA Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L27 YP_514107.1 1378881 R 376619 CDS YP_514108.1 89256746 3952027 complement(1379166..1379480) 1 NC_007880.1 50S ribosomal protein L21 1379480 rplU 3952027 rplU Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L21 YP_514108.1 1379166 R 376619 CDS YP_514109.1 89256747 3952032 complement(1381543..1384263) 1 NC_007880.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1384263 3952032 FTL_1458 Francisella tularensis subsp. holarctica LVS preprotein translocase subunit SecA YP_514109.1 1381543 R 376619 CDS YP_514110.1 89256748 3952033 1384395..1385423 1 NC_007880.1 hypothetical protein 1385423 3952033 FTL_1459 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514110.1 1384395 D 376619 CDS YP_514111.1 89256749 3952482 1385427..1385876 1 NC_007880.1 hypothetical protein 1385876 3952482 FTL_1460 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514111.1 1385427 D 376619 CDS YP_514112.1 89256750 3952483 complement(1385873..1386595) 1 NC_007880.1 purine nucleoside phosphorylase 1386595 3952483 FTL_1461 Francisella tularensis subsp. holarctica LVS purine nucleoside phosphorylase YP_514112.1 1385873 R 376619 CDS YP_514113.1 89256751 3952119 complement(join(1386668..1387224,1387224..1387548)) 1 NC_007880.1 transposase 1387548 isftu1 3952119 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514113.1 1386668 R 376619 CDS YP_514114.1 89256752 3951694 1387853..1388482 1 NC_007880.1 transposase 1388482 isftu2 3951694 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_514114.1 1387853 D 376619 CDS YP_514115.1 89256753 3952484 complement(1388576..1390522) 1 NC_007880.1 ATP-dependent metalloprotease 1390522 3952484 FTL_1464 Francisella tularensis subsp. holarctica LVS ATP-dependent metalloprotease YP_514115.1 1388576 R 376619 CDS YP_514116.1 89256754 3952485 1390733..1390930 1 NC_007880.1 hypothetical protein 1390930 3952485 FTL_1465 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514116.1 1390733 D 376619 CDS YP_514117.1 89256755 3952486 1390974..1391549 1 NC_007880.1 major facilitator transporter 1391549 3952486 FTL_1466 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514117.1 1390974 D 376619 CDS YP_514118.1 89256756 3951695 1391767..1392396 1 NC_007880.1 transposase 1392396 isftu2 3951695 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_514118.1 1391767 D 376619 CDS YP_514119.1 89256757 3952487 complement(1392490..1394436) 1 NC_007880.1 ATP-dependent metalloprotease 1394436 3952487 FTL_1468 Francisella tularensis subsp. holarctica LVS ATP-dependent metalloprotease YP_514119.1 1392490 R 376619 CDS YP_514120.1 89256758 3952488 1394647..1394844 1 NC_007880.1 hypothetical protein 1394844 3952488 FTL_1469 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514120.1 1394647 D 376619 CDS YP_514121.1 89256759 3952489 1394888..1395463 1 NC_007880.1 major facilitator transporter 1395463 3952489 FTL_1470 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514121.1 1394888 D 376619 CDS YP_514122.1 89256760 3951696 1395681..1396319 1 NC_007880.1 transposase 1396319 isftu2 3951696 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_514122.1 1395681 D 376619 CDS YP_514123.1 89256761 3952490 1396492..1396890 1 NC_007880.1 hypothetical protein 1396890 3952490 FTL_1472 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514123.1 1396492 D 376619 CDS YP_514124.1 89256762 3952491 complement(1396896..1399718) 1 NC_007880.1 DNA excision repair protein subunit A 1399718 3952491 FTL_1473 Francisella tularensis subsp. holarctica LVS DNA excision repair protein subunit A YP_514124.1 1396896 R 376619 CDS YP_514125.1 89256763 3952492 complement(1399757..1400239) 1 NC_007880.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1400239 greA 3952492 greA Francisella tularensis subsp. holarctica LVS transcription elongation factor GreA YP_514125.1 1399757 R 376619 CDS YP_514126.1 89256764 3952493 complement(1400273..1400857) 1 NC_007880.1 Type IV pili fiber building block protein 1400857 3952493 FTL_1475 Francisella tularensis subsp. holarctica LVS Type IV pili fiber building block protein YP_514126.1 1400273 R 376619 CDS YP_514127.1 89256765 3952494 complement(1400858..1402480) 1 NC_007880.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1402480 pgi 3952494 pgi Francisella tularensis subsp. holarctica LVS glucose-6-phosphate isomerase YP_514127.1 1400858 R 376619 CDS YP_514128.1 89256766 3952495 complement(1402467..1403120) 1 NC_007880.1 thiamine pyrophospokinase 1403120 3952495 FTL_1477 Francisella tularensis subsp. holarctica LVS thiamine pyrophospokinase YP_514128.1 1402467 R 376619 CDS YP_514129.1 89256767 3952496 complement(1403186..1404646) 1 NC_007880.1 inosine-5-monophosphate dehydrogenase 1404646 3952496 FTL_1478 Francisella tularensis subsp. holarctica LVS inosine-5-monophosphate dehydrogenase YP_514129.1 1403186 R 376619 CDS YP_514130.1 89256768 3952497 complement(1404747..1406186) 1 NC_007880.1 cytosol aminopeptidase 1406186 3952497 FTL_1479 Francisella tularensis subsp. holarctica LVS cytosol aminopeptidase YP_514130.1 1404747 R 376619 CDS YP_514131.1 89256769 3952498 1406352..1407434 1 NC_007880.1 YjgP/YjgQ family permease 1407434 3952498 FTL_1480 Francisella tularensis subsp. holarctica LVS YjgP/YjgQ family permease YP_514131.1 1406352 D 376619 CDS YP_514132.1 89256770 3952499 1407434..1408495 1 NC_007880.1 YjgP/YjgQ family permease 1408495 3952499 FTL_1481 Francisella tularensis subsp. holarctica LVS YjgP/YjgQ family permease YP_514132.1 1407434 D 376619 CDS YP_514133.1 89256771 3952500 1408503..1409756 1 NC_007880.1 peptidase M16 family protein 1409756 3952500 FTL_1482 Francisella tularensis subsp. holarctica LVS peptidase M16 family protein YP_514133.1 1408503 D 376619 CDS YP_514134.1 89256772 3952501 1409763..1410986 1 NC_007880.1 peptidase M16 family protein 1410986 3952501 FTL_1483 Francisella tularensis subsp. holarctica LVS peptidase M16 family protein YP_514134.1 1409763 D 376619 CDS YP_514135.1 89256773 3951585 1410987..1411565 1 NC_007880.1 methylase 1411565 3951585 FTL_1484 Francisella tularensis subsp. holarctica LVS methylase YP_514135.1 1410987 D 376619 CDS YP_514136.1 89256774 3951586 1411599..1412249 1 NC_007880.1 hypothetical protein 1412249 3951586 FTL_1485 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514136.1 1411599 D 376619 CDS YP_514137.1 89256775 3951587 complement(1412302..1412913) 1 NC_007880.1 tRNA-(ms(2)io(6)a)-hydroxylase 1412913 3951587 FTL_1486 Francisella tularensis subsp. holarctica LVS tRNA-(ms(2)io(6)a)-hydroxylase YP_514137.1 1412302 R 376619 CDS YP_514138.1 89256776 3951588 1413029..1413832 1 NC_007880.1 uridine phosphorylase 1413832 3951588 FTL_1487 Francisella tularensis subsp. holarctica LVS uridine phosphorylase YP_514138.1 1413029 D 376619 CDS YP_514139.1 89256777 3951589 1413853..1414254 1 NC_007880.1 cytidine deaminase 1414254 3951589 FTL_1488 Francisella tularensis subsp. holarctica LVS cytidine deaminase YP_514139.1 1413853 D 376619 CDS YP_514140.1 89256778 3951590 complement(1414446..1417481) 1 NC_007880.1 FAD-binding family protein 1417481 3951590 FTL_1489 Francisella tularensis subsp. holarctica LVS FAD-binding family protein YP_514140.1 1414446 R 376619 CDS YP_514141.1 89256779 3951591 1417700..1419238 1 NC_007880.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 1419238 3951591 FTL_1490 Francisella tularensis subsp. holarctica LVS phosphoglyceromutase YP_514141.1 1417700 D 376619 CDS YP_514142.1 89256780 3951592 1419253..1420533 1 NC_007880.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1420533 3951592 FTL_1491 Francisella tularensis subsp. holarctica LVS seryl-tRNA synthetase YP_514142.1 1419253 D 376619 CDS YP_514143.1 89256781 3951593 1420643..1421542 1 NC_007880.1 fructokinase 1421542 3951593 FTL_1492 Francisella tularensis subsp. holarctica LVS fructokinase YP_514143.1 1420643 D 376619 CDS YP_514144.1 89256782 3951594 1421671..1422879 1 NC_007880.1 polysaccharide biosynthesis protein (export protein) 1422879 3951594 FTL_1493 Francisella tularensis subsp. holarctica LVS polysaccharide biosynthesis protein (export protein) YP_514144.1 1421671 D 376619 CDS YP_514145.1 89256783 3951595 complement(1423111..1423620) 1 NC_007880.1 hypothetical protein 1423620 3951595 FTL_1494 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514145.1 1423111 R 376619 CDS YP_514146.1 89256784 3951596 1423997..1425778 1 NC_007880.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1425778 3951596 FTL_1495 Francisella tularensis subsp. holarctica LVS cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_514146.1 1423997 D 376619 CDS YP_514147.1 89256785 3951597 1425775..1427424 1 NC_007880.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1427424 3951597 FTL_1496 Francisella tularensis subsp. holarctica LVS cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_514147.1 1425775 D 376619 CDS YP_514148.1 89256786 3951598 complement(1427426..1428676) 1 NC_007880.1 C4-dicarboxylate transport protein 1428676 3951598 FTL_1497 Francisella tularensis subsp. holarctica LVS C4-dicarboxylate transport protein YP_514148.1 1427426 R 376619 CDS YP_514149.1 89256787 3951599 complement(1428815..1429195) 1 NC_007880.1 translation initiation inhibitor 1429195 3951599 FTL_1498 Francisella tularensis subsp. holarctica LVS translation initiation inhibitor YP_514149.1 1428815 R 376619 CDS YP_514150.1 89256788 3951600 complement(1429195..1430739) 1 NC_007880.1 sulfate permease family protein 1430739 3951600 FTL_1499 Francisella tularensis subsp. holarctica LVS sulfate permease family protein YP_514150.1 1429195 R 376619 CDS YP_514151.1 89256789 3951601 complement(1430858..1431334) 1 NC_007880.1 transposase 1431334 3951601 FTL_1500 Francisella tularensis subsp. holarctica LVS transposase YP_514151.1 1430858 R 376619 CDS YP_514152.1 89256790 3951602 1431708..1432928 1 NC_007880.1 major facilitator transporter 1432928 3951602 FTL_1502 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514152.1 1431708 D 376619 CDS YP_514153.1 89256791 3951603 complement(1432912..1434237) 1 NC_007880.1 deoxyguanosinetriphosphate triphosphohydrolase 1434237 3951603 FTL_1503 Francisella tularensis subsp. holarctica LVS deoxyguanosinetriphosphate triphosphohydrolase YP_514153.1 1432912 R 376619 CDS YP_514154.1 89256792 3952054 complement(1434341..1436527) 1 NC_007880.1 peroxidase/catalase 1436527 3952054 FTL_1504 Francisella tularensis subsp. holarctica LVS peroxidase/catalase YP_514154.1 1434341 R 376619 CDS YP_514155.1 89256793 3952120 complement(join(1437326..1437880,1437880..1438206)) 1 NC_007880.1 transposase 1438206 isftu1 3952120 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514155.1 1437326 R 376619 CDS YP_514156.1 89256794 3952055 complement(1438513..1438962) 1 NC_007880.1 short-chain dehydrogenase 1438962 3952055 FTL_1506 Francisella tularensis subsp. holarctica LVS short-chain dehydrogenase YP_514156.1 1438513 R 376619 CDS YP_514157.1 89256795 3952056 complement(1438968..1439294) 1 NC_007880.1 3-oxoacyl-ACP reductase 1439294 3952056 FTL_1507 Francisella tularensis subsp. holarctica LVS 3-oxoacyl-ACP reductase YP_514157.1 1438968 R 376619 CDS YP_514158.1 89256796 3952058 complement(1440148..1440678) 1 NC_007880.1 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase 1440678 3952058 FTL_1509 Francisella tularensis subsp. holarctica LVS D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase YP_514158.1 1440148 R 376619 CDS YP_514159.1 89256797 3952059 complement(1440694..1442010) 1 NC_007880.1 glycerol-3-phosphate transporter 1442010 3952059 FTL_1510 Francisella tularensis subsp. holarctica LVS glycerol-3-phosphate transporter YP_514159.1 1440694 R 376619 CDS YP_514160.1 89256798 3952060 complement(1442117..1443151) 1 NC_007880.1 glycerophosphoryl diester phosphodiesterase family protein 1443151 3952060 FTL_1511 Francisella tularensis subsp. holarctica LVS glycerophosphoryl diester phosphodiesterase family protein YP_514160.1 1442117 R 376619 CDS YP_514161.1 89256799 3952061 1443453..1444256 1 NC_007880.1 hypothetical protein 1444256 3952061 FTL_1512 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514161.1 1443453 D 376619 CDS YP_514162.1 89256800 3952062 1444253..1445185 1 NC_007880.1 ABC transporter ATP-binding protein 1445185 3952062 FTL_1513 Francisella tularensis subsp. holarctica LVS ABC transporter ATP-binding protein YP_514162.1 1444253 D 376619 CDS YP_514163.1 89256801 3952063 1445182..1445604 1 NC_007880.1 ABC transporter permease 1445604 3952063 FTL_1514 Francisella tularensis subsp. holarctica LVS ABC transporter permease YP_514163.1 1445182 D 376619 CDS YP_514164.1 89256802 3952064 1445743..1446297 1 NC_007880.1 ABC transporter membrane protein 1446297 3952064 FTL_1515 Francisella tularensis subsp. holarctica LVS ABC transporter membrane protein YP_514164.1 1445743 D 376619 CDS YP_514165.1 89256803 3951698 1446542..1447135 1 NC_007880.1 transposase 1447135 isftu2 3951698 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_514165.1 1446542 D 376619 CDS YP_514166.1 89256804 3952065 complement(1447184..1447528) 1 NC_007880.1 hypothetical protein 1447528 3952065 FTL_1517 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514166.1 1447184 R 376619 CDS YP_514167.1 89256805 3952068 complement(1448536..1449165) 1 NC_007880.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 1449165 upp 3952068 upp Francisella tularensis subsp. holarctica LVS uracil phosphoribosyltransferase YP_514167.1 1448536 R 376619 CDS YP_514168.1 89256806 3952069 complement(1449357..1451651) 1 NC_007880.1 chitinase family 18 protein 1451651 3952069 FTL_1521 Francisella tularensis subsp. holarctica LVS chitinase family 18 protein YP_514168.1 1449357 R 376619 CDS YP_514169.1 89256807 3952070 1452185..1453381 1 NC_007880.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 1453381 3952070 FTL_1522 Francisella tularensis subsp. holarctica LVS 2-amino-3-ketobutyrate coenzyme A ligase YP_514169.1 1452185 D 376619 CDS YP_514170.1 89256808 3952071 1453404..1454459 1 NC_007880.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 1454459 tdh 3952071 tdh Francisella tularensis subsp. holarctica LVS L-threonine 3-dehydrogenase YP_514170.1 1453404 D 376619 CDS YP_514171.1 89256809 3952072 1454461..1455723 1 NC_007880.1 serine transporter 1455723 3952072 FTL_1524 Francisella tularensis subsp. holarctica LVS serine transporter YP_514171.1 1454461 D 376619 CDS YP_514172.1 89256810 3952073 complement(1455728..1456417) 1 NC_007880.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1456417 3952073 FTL_1525 Francisella tularensis subsp. holarctica LVS 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_514172.1 1455728 R 376619 CDS YP_514173.1 89256811 3950839 complement(1456407..1456697) 1 NC_007880.1 cell division protein 1456697 3950839 FTL_1526 Francisella tularensis subsp. holarctica LVS cell division protein YP_514173.1 1456407 R 376619 CDS YP_514174.1 89256812 3950840 complement(1456705..1458075) 1 NC_007880.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1458075 eno 3950840 eno Francisella tularensis subsp. holarctica LVS phosphopyruvate hydratase YP_514174.1 1456705 R 376619 CDS YP_514175.1 89256813 3950841 complement(1458184..1459422) 1 NC_007880.1 major facilitator transporter 1459422 3950841 FTL_1528 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514175.1 1458184 R 376619 CDS YP_514176.1 89256814 3950842 complement(1459525..1460289) 1 NC_007880.1 nicotinamide mononucleotide transport (NMT) family protein 1460289 3950842 FTL_1529 Francisella tularensis subsp. holarctica LVS nicotinamide mononucleotide transport (NMT) family protein YP_514176.1 1459525 R 376619 CDS YP_514177.1 89256815 3950844 complement(1461047..1462396) 1 NC_007880.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 1462396 rumA 3950844 rumA Francisella tularensis subsp. holarctica LVS 23S rRNA 5-methyluridine methyltransferase YP_514177.1 1461047 R 376619 CDS YP_514178.1 89256816 3950845 complement(1462485..1463057) 1 NC_007880.1 hypothetical protein 1463057 3950845 FTL_1532 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514178.1 1462485 R 376619 CDS YP_514179.1 89256817 3950846 complement(1463322..1463540) 1 NC_007880.1 DNA-directed RNA polymerase subunit omega 1463540 3950846 FTL_1533 Francisella tularensis subsp. holarctica LVS DNA-directed RNA polymerase subunit omega YP_514179.1 1463322 R 376619 CDS YP_514180.1 89256818 3950847 complement(1463533..1464198) 1 NC_007880.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1464198 3950847 FTL_1534 Francisella tularensis subsp. holarctica LVS uridine kinase YP_514180.1 1463533 R 376619 CDS YP_514181.1 89256819 3950848 complement(1464209..1465036) 1 NC_007880.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1465036 3950848 FTL_1535 Francisella tularensis subsp. holarctica LVS 2-dehydro-3-deoxyphosphooctonate aldolase YP_514181.1 1464209 R 376619 CDS YP_514182.1 89256820 3950849 complement(1465067..1465417) 1 NC_007880.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 1465417 3950849 FTL_1536 Francisella tularensis subsp. holarctica LVS iron-sulfur cluster insertion protein ErpA YP_514182.1 1465067 R 376619 CDS YP_514183.1 89256821 3950850 complement(1465423..1467504) 1 NC_007880.1 polynucleotide phosphorylase/polyadenylase 1467504 3950850 FTL_1537 Francisella tularensis subsp. holarctica LVS polynucleotide phosphorylase/polyadenylase YP_514183.1 1465423 R 376619 CDS YP_514184.1 89256822 3950851 complement(1467561..1467827) 1 NC_007880.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1467827 rpsO 3950851 rpsO Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S15 YP_514184.1 1467561 R 376619 CDS YP_514185.1 89256823 3950852 complement(1467933..1469627) 1 NC_007880.1 penicillin binding protein (peptidoglycan synthetase) 1469627 3950852 FTL_1539 Francisella tularensis subsp. holarctica LVS penicillin binding protein (peptidoglycan synthetase) YP_514185.1 1467933 R 376619 CDS YP_514186.1 89256824 3950853 complement(1469620..1469970) 1 NC_007880.1 hypothetical protein 1469970 3950853 FTL_1540 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514186.1 1469620 R 376619 CDS YP_514187.1 89256825 3950854 complement(1469967..1470884) 1 NC_007880.1 S-adenosyl-methyltransferase MraW 1470884 mraW 3950854 mraW Francisella tularensis subsp. holarctica LVS S-adenosyl-methyltransferase MraW YP_514187.1 1469967 R 376619 CDS YP_514188.1 89256826 3950855 complement(1470890..1472989) 1 NC_007880.1 hypothetical protein 1472989 3950855 FTL_1542 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514188.1 1470890 R 376619 CDS YP_514189.1 89256827 3950856 1473082..1473906 1 NC_007880.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 1473906 3950856 FTL_1543 Francisella tularensis subsp. holarctica LVS formamidopyrimidine-DNA glycosylase YP_514189.1 1473082 D 376619 CDS YP_514190.1 89256828 3952121 join(1473977..1474301,1474301..1474857) 1 NC_007880.1 transposase 1474857 isftu1 3952121 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514190.1 1473977 D 376619 CDS YP_514191.1 89256829 3950857 complement(1474865..1475404) 1 NC_007880.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 1475404 3950857 FTL_1545 Francisella tularensis subsp. holarctica LVS glutamine amidotransferase subunit PdxT YP_514191.1 1474865 R 376619 CDS YP_514192.1 89256830 3951819 complement(1475407..1476270) 1 NC_007880.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 1476270 3951819 FTL_1546 Francisella tularensis subsp. holarctica LVS pyridoxal biosynthesis lyase PdxS YP_514192.1 1475407 R 376619 CDS YP_514193.1 89256831 3951820 complement(1476400..1478811) 1 NC_007880.1 DNA gyrase subunit B 1478811 3951820 FTL_1547 Francisella tularensis subsp. holarctica LVS DNA gyrase subunit B YP_514193.1 1476400 R 376619 CDS YP_514194.1 89256832 3951821 1478993..1479793 1 NC_007880.1 hypothetical protein 1479793 3951821 FTL_1548 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514194.1 1478993 D 376619 CDS YP_514195.1 89256833 3951822 1479827..1480810 1 NC_007880.1 tRNA-dihydrouridine synthase A 1480810 3951822 FTL_1549 Francisella tularensis subsp. holarctica LVS tRNA-dihydrouridine synthase A YP_514195.1 1479827 D 376619 CDS YP_514196.1 89256834 3951823 complement(1480817..1481584) 1 NC_007880.1 lipoprotein 1481584 3951823 FTL_1550 Francisella tularensis subsp. holarctica LVS lipoprotein YP_514196.1 1480817 R 376619 CDS YP_514197.1 89256835 3951824 1482252..1482566 1 NC_007880.1 hypothetical protein 1482566 3951824 FTL_1551 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514197.1 1482252 D 376619 CDS YP_514198.1 89256836 3951825 complement(1482574..1484487) 1 NC_007880.1 hypothetical protein 1484487 3951825 FTL_1552 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514198.1 1482574 R 376619 CDS YP_514199.1 89256837 3951826 1484657..1485820 1 NC_007880.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1485820 sucC 3951826 sucC Francisella tularensis subsp. holarctica LVS succinyl-CoA synthetase subunit beta YP_514199.1 1484657 D 376619 CDS YP_514200.1 89256838 3951827 1485852..1486724 1 NC_007880.1 succinyl-CoA synthetase, alpha subunit 1486724 3951827 FTL_1554 Francisella tularensis subsp. holarctica LVS succinyl-CoA synthetase, alpha subunit YP_514200.1 1485852 D 376619 CDS YP_514201.1 89256839 3951828 1486834..1487259 1 NC_007880.1 hypothetical protein 1487259 3951828 FTL_1555 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514201.1 1486834 D 376619 CDS YP_514202.1 89256840 3951829 1487658..1488683 1 NC_007880.1 hypothetical protein 1488683 3951829 FTL_1556 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514202.1 1487658 D 376619 CDS YP_514203.1 89256841 3951830 complement(1488815..1489495) 1 NC_007880.1 hypothetical protein 1489495 3951830 FTL_1557 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514203.1 1488815 R 376619 CDS YP_514204.1 89256842 3951831 complement(1489504..1490028) 1 NC_007880.1 hypothetical protein 1490028 3951831 FTL_1558 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514204.1 1489504 R 376619 CDS YP_514205.1 89256843 3951898 1494231..1494953 1 NC_007880.1 CutC family protein 1494953 3951898 FTL_1566 Francisella tularensis subsp. holarctica LVS CutC family protein YP_514205.1 1494231 D 376619 CDS YP_514206.1 89256844 3951899 complement(1494968..1496134) 1 NC_007880.1 major facilitator transporter 1496134 3951899 FTL_1567 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514206.1 1494968 R 376619 CDS YP_514207.1 89256845 3951900 1496245..1497165 1 NC_007880.1 LysR family transcriptional regulator 1497165 3951900 FTL_1568 Francisella tularensis subsp. holarctica LVS LysR family transcriptional regulator YP_514207.1 1496245 D 376619 CDS YP_514208.1 89256846 3951901 1497208..1497867 1 NC_007880.1 phosphoglycolate phosphatase 1497867 3951901 FTL_1569 Francisella tularensis subsp. holarctica LVS phosphoglycolate phosphatase YP_514208.1 1497208 D 376619 CDS YP_514209.1 89256847 3951902 1497910..1499127 1 NC_007880.1 phospholipase D 1499127 3951902 FTL_1570 Francisella tularensis subsp. holarctica LVS phospholipase D YP_514209.1 1497910 D 376619 CDS YP_514210.1 89256848 3951903 1499219..1500169 1 NC_007880.1 thioredoxin reductase 1500169 3951903 FTL_1571 Francisella tularensis subsp. holarctica LVS thioredoxin reductase YP_514210.1 1499219 D 376619 CDS YP_514211.1 89256849 3951699 1500465..1501124 1 NC_007880.1 transposase 1501124 isftu2 3951699 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_514211.1 1500465 D 376619 CDS YP_514212.1 89256850 3951904 1501135..1501824 1 NC_007880.1 major facilitator transporter 1501824 3951904 FTL_1573 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514212.1 1501135 D 376619 CDS YP_514213.1 89256851 3951905 1501930..1502301 1 NC_007880.1 hypothetical protein 1502301 3951905 FTL_1574 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514213.1 1501930 D 376619 CDS YP_514214.1 89256852 3951906 complement(1502373..1503209) 1 NC_007880.1 hypothetical protein 1503209 3951906 FTL_1575 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514214.1 1502373 R 376619 CDS YP_514215.1 89256853 3951907 complement(1503393..1505195) 1 NC_007880.1 DNA mismatch repair protein 1505195 3951907 FTL_1576 Francisella tularensis subsp. holarctica LVS DNA mismatch repair protein YP_514215.1 1503393 R 376619 CDS YP_514216.1 89256854 3951908 complement(1505203..1505538) 1 NC_007880.1 hypothetical protein 1505538 3951908 FTL_1577 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514216.1 1505203 R 376619 CDS YP_514217.1 89256855 3951909 complement(1505522..1505866) 1 NC_007880.1 hypothetical protein 1505866 3951909 FTL_1578 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514217.1 1505522 R 376619 CDS YP_514218.1 89256856 3951910 complement(1505934..1506653) 1 NC_007880.1 hypothetical protein 1506653 3951910 FTL_1579 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514218.1 1505934 R 376619 CDS YP_514219.1 89256857 3951911 1506807..1507694 1 NC_007880.1 hypothetical protein 1507694 3951911 FTL_1580 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514219.1 1506807 D 376619 CDS YP_514220.1 89256858 3951912 1507913..1508728 1 NC_007880.1 lipoprotein 1508728 3951912 FTL_1581 Francisella tularensis subsp. holarctica LVS lipoprotein YP_514220.1 1507913 D 376619 CDS YP_514221.1 89256859 3951913 complement(1508981..1510162) 1 NC_007880.1 putrescine-binding periplasmic protein 1510162 3951913 FTL_1582 Francisella tularensis subsp. holarctica LVS putrescine-binding periplasmic protein YP_514221.1 1508981 R 376619 CDS YP_514222.1 89256860 3951914 1510246..1511655 1 NC_007880.1 glutamate:gamma-aminobutyric acid antiporter family protein 1511655 3951914 FTL_1583 Francisella tularensis subsp. holarctica LVS glutamate:gamma-aminobutyric acid antiporter family protein YP_514222.1 1510246 D 376619 CDS YP_514223.1 89256861 3951915 1511757..1512863 1 NC_007880.1 PerM family protein 1512863 3951915 FTL_1584 Francisella tularensis subsp. holarctica LVS PerM family protein YP_514223.1 1511757 D 376619 CDS YP_514224.1 89256862 3951916 1512857..1514599 1 NC_007880.1 single-stranded-DNA-specific exonuclease 1514599 3951916 FTL_1585 Francisella tularensis subsp. holarctica LVS single-stranded-DNA-specific exonuclease YP_514224.1 1512857 D 376619 CDS YP_514225.1 89256863 3951937 1514596..1515378 1 NC_007880.1 biotin--acetyl-CoA-carboxylase ligase 1515378 3951937 FTL_1586 Francisella tularensis subsp. holarctica LVS biotin--acetyl-CoA-carboxylase ligase YP_514225.1 1514596 D 376619 CDS YP_514226.1 89256864 3951938 1515375..1516298 1 NC_007880.1 lysyl-tRNA synthetase 1516298 3951938 FTL_1587 Francisella tularensis subsp. holarctica LVS lysyl-tRNA synthetase YP_514226.1 1515375 D 376619 CDS YP_514227.1 89256865 3951939 complement(1516303..1517148) 1 NC_007880.1 mechanosensitive ion channel protein 1517148 3951939 FTL_1588 Francisella tularensis subsp. holarctica LVS mechanosensitive ion channel protein YP_514227.1 1516303 R 376619 CDS YP_514228.1 89256866 3951700 complement(1516986..1517717) 1 NC_007880.1 transposase 1517717 isftu2 3951700 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_514228.1 1516986 R 376619 CDS YP_514229.1 89256867 3951940 complement(1518304..1518984) 1 NC_007880.1 hypothetical protein 1518984 3951940 FTL_1590 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514229.1 1518304 R 376619 CDS YP_514230.1 89256868 3951941 complement(1519078..1520433) 1 NC_007880.1 Acetyl-CoA carboxylase, biotin carboxylase subunit 1520433 3951941 FTL_1591 Francisella tularensis subsp. holarctica LVS Acetyl-CoA carboxylase, biotin carboxylase subunit YP_514230.1 1519078 R 376619 CDS YP_514231.1 89256869 3951942 complement(1520498..1520971) 1 NC_007880.1 Acetyl-CoA carboxylase, biotin carboxyl carrier protein subunit 1520971 3951942 FTL_1592 Francisella tularensis subsp. holarctica LVS Acetyl-CoA carboxylase, biotin carboxyl carrier protein subunit YP_514231.1 1520498 R 376619 CDS YP_514232.1 89256870 3951943 complement(1520976..1521413) 1 NC_007880.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 1521413 3951943 FTL_1593 Francisella tularensis subsp. holarctica LVS 3-dehydroquinate dehydratase YP_514232.1 1520976 R 376619 CDS YP_514233.1 89256871 3951944 complement(1521417..1522244) 1 NC_007880.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 1522244 apaH 3951944 apaH Francisella tularensis subsp. holarctica LVS diadenosine tetraphosphatase YP_514233.1 1521417 R 376619 CDS YP_514234.1 89256872 3951945 complement(1522256..1523044) 1 NC_007880.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1523044 ksgA 3951945 ksgA Francisella tularensis subsp. holarctica LVS dimethyladenosine transferase YP_514234.1 1522256 R 376619 CDS YP_514235.1 89256873 3951946 complement(1523046..1524455) 1 NC_007880.1 peptidyl-prolyl cis-trans isomerase 1524455 3951946 FTL_1596 Francisella tularensis subsp. holarctica LVS peptidyl-prolyl cis-trans isomerase YP_514235.1 1523046 R 376619 CDS YP_514236.1 89256874 3951947 complement(1524455..1527061) 1 NC_007880.1 organic solvent tolerance protein 1527061 3951947 FTL_1597 Francisella tularensis subsp. holarctica LVS organic solvent tolerance protein YP_514236.1 1524455 R 376619 CDS YP_514237.1 89256875 3951948 1527187..1528932 1 NC_007880.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1528932 argS 3951948 argS Francisella tularensis subsp. holarctica LVS arginyl-tRNA synthetase YP_514237.1 1527187 D 376619 CDS YP_514238.1 89256876 3951949 complement(1528984..1529370) 1 NC_007880.1 hypothetical protein 1529370 3951949 FTL_1599 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514238.1 1528984 R 376619 CDS YP_514239.1 89256877 3951950 complement(1529789..1530709) 1 NC_007880.1 periplasmic L-asparaginase II 1530709 3951950 FTL_1600 Francisella tularensis subsp. holarctica LVS periplasmic L-asparaginase II YP_514239.1 1529789 R 376619 CDS YP_514240.1 89256878 3951951 complement(1530970..1531437) 1 NC_007880.1 tRNA/rRNA methyltransferase 1531437 3951951 FTL_1601 Francisella tularensis subsp. holarctica LVS tRNA/rRNA methyltransferase YP_514240.1 1530970 R 376619 CDS YP_514241.1 89256879 3951952 complement(1531440..1532414) 1 NC_007880.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 1532414 3951952 FTL_1602 Francisella tularensis subsp. holarctica LVS delta-aminolevulinic acid dehydratase YP_514241.1 1531440 R 376619 CDS YP_514242.1 89256880 3951953 complement(1532422..1532700) 1 NC_007880.1 RNA-binding protein 1532700 3951953 FTL_1603 Francisella tularensis subsp. holarctica LVS RNA-binding protein YP_514242.1 1532422 R 376619 CDS YP_514243.1 89256881 3951954 complement(1532711..1533622) 1 NC_007880.1 DNA polymerase III, delta prime subunit 1533622 3951954 FTL_1604 Francisella tularensis subsp. holarctica LVS DNA polymerase III, delta prime subunit YP_514243.1 1532711 R 376619 CDS YP_514244.1 89256882 3951955 complement(1533630..1534646) 1 NC_007880.1 SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease 1534646 3951955 FTL_1605 Francisella tularensis subsp. holarctica LVS putative periplasmic protease YP_514244.1 1533630 R 376619 CDS YP_514245.1 89256883 3951956 complement(1534658..1535287) 1 NC_007880.1 stringent starvation protein A 1535287 3951956 FTL_1606 Francisella tularensis subsp. holarctica LVS stringent starvation protein A YP_514245.1 1534658 R 376619 CDS YP_514246.1 89256884 3951996 1535376..1535690 1 NC_007880.1 anaerobic sulfite reductase subunit 1535690 3951996 FTL_1607 Francisella tularensis subsp. holarctica LVS anaerobic sulfite reductase subunit YP_514246.1 1535376 D 376619 CDS YP_514247.1 89256885 3951997 1535711..1535974 1 NC_007880.1 hypothetical protein 1535974 3951997 FTL_1608 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514247.1 1535711 D 376619 CDS YP_514248.1 89256886 3951998 1536066..1537826 1 NC_007880.1 dolichyl-phosphate-mannose-protein mannosyltransferase family protein 1537826 3951998 FTL_1609 Francisella tularensis subsp. holarctica LVS dolichyl-phosphate-mannose-protein mannosyltransferase family protein YP_514248.1 1536066 D 376619 CDS YP_514249.1 89256887 3952122 complement(join(1538111..1538665,1538665..1538991)) 1 NC_007880.1 transposase 1538991 isftu1 3952122 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514249.1 1538111 R 376619 CDS YP_514250.1 89256888 3951999 complement(1539150..1540103) 1 NC_007880.1 glycosyl transferase family protein 1540103 3951999 FTL_1611 Francisella tularensis subsp. holarctica LVS glycosyl transferase family protein YP_514250.1 1539150 R 376619 CDS YP_514251.1 89256889 3952000 1540205..1541011 1 NC_007880.1 hypothetical protein 1541011 3952000 FTL_1612 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514251.1 1540205 D 376619 CDS YP_514252.1 89256890 3952001 complement(1541019..1542224) 1 NC_007880.1 cell division protein FtsW 1542224 3952001 FTL_1613 Francisella tularensis subsp. holarctica LVS cell division protein FtsW YP_514252.1 1541019 R 376619 CDS YP_514253.1 89256891 3952002 complement(1542234..1543484) 1 NC_007880.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase 1543484 3952002 FTL_1614 Francisella tularensis subsp. holarctica LVS UDP-N-acetylmuramoylalanine--D-glutamate ligase YP_514253.1 1542234 R 376619 CDS YP_514254.1 89256892 3952003 complement(1543484..1544581) 1 NC_007880.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1544581 mraY 3952003 mraY Francisella tularensis subsp. holarctica LVS phospho-N-acetylmuramoyl-pentapeptide- transferase YP_514254.1 1543484 R 376619 CDS YP_514255.1 89256893 3952004 complement(1544656..1546242) 1 NC_007880.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 1546242 3952004 FTL_1616 Francisella tularensis subsp. holarctica LVS phosphoenolpyruvate carboxykinase YP_514255.1 1544656 R 376619 CDS YP_514256.1 89256894 3952005 1546393..1548039 1 NC_007880.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 1548039 3952005 FTL_1617 Francisella tularensis subsp. holarctica LVS glutaminyl-tRNA synthetase YP_514256.1 1546393 D 376619 CDS YP_514257.1 89256895 3952006 1548060..1548641 1 NC_007880.1 hypothetical protein 1548641 3952006 FTL_1618 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514257.1 1548060 D 376619 CDS YP_514258.1 89256896 3952007 1548593..1549348 1 NC_007880.1 hypothetical protein 1549348 3952007 FTL_1619 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514258.1 1548593 D 376619 CDS YP_514259.1 89256897 3952008 complement(1549544..1550017) 1 NC_007880.1 proton-dependent oligopeptide transport (POT) family protein 1550017 3952008 FTL_1620 Francisella tularensis subsp. holarctica LVS proton-dependent oligopeptide transport (POT) family protein YP_514259.1 1549544 R 376619 CDS YP_514260.1 89256898 3952009 complement(1550089..1551930) 1 NC_007880.1 ABC transporter ATP-binding 1551930 3952009 FTL_1621 Francisella tularensis subsp. holarctica LVS ABC transporter ATP-binding YP_514260.1 1550089 R 376619 CDS YP_514261.1 89256899 3952010 complement(1551964..1553190) 1 NC_007880.1 multidrug transporter (tetracycline resistance protein) 1553190 3952010 FTL_1622 Francisella tularensis subsp. holarctica LVS multidrug transporter (tetracycline resistance protein) YP_514261.1 1551964 R 376619 CDS YP_514262.1 89256900 3952011 complement(1553273..1554316) 1 NC_007880.1 hypothetical protein 1554316 3952011 FTL_1623 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514262.1 1553273 R 376619 CDS YP_514263.1 89256901 3952012 1554588..1555781 1 NC_007880.1 major facilitator transporter 1555781 3952012 FTL_1624 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514263.1 1554588 D 376619 CDS YP_514264.1 89256902 3952013 1555811..1556455 1 NC_007880.1 NADH dehydrogenase subunit 1556455 3952013 FTL_1625 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase subunit YP_514264.1 1555811 D 376619 CDS YP_514265.1 89256903 3952014 complement(1556471..1556662) 1 NC_007880.1 rRNA methylase 1556662 3952014 FTL_1626 Francisella tularensis subsp. holarctica LVS rRNA methylase YP_514265.1 1556471 R 376619 CDS YP_514266.1 89256904 3952123 join(1556653..1556979,1556979..1557533) 1 NC_007880.1 transposase 1557533 isftu1 3952123 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514266.1 1556653 D 376619 CDS YP_514267.1 89256905 3952741 1557758..1558471 1 NC_007880.1 hypothetical protein 1558471 3952741 FTL_1628 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514267.1 1557758 D 376619 CDS YP_514268.1 89256906 3952742 1558425..1560131 1 NC_007880.1 hypothetical protein 1560131 3952742 FTL_1629 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514268.1 1558425 D 376619 CDS YP_514269.1 89256907 3952124 complement(join(1560132..1560686,1560686..1561012)) 1 NC_007880.1 transposase 1561012 isftu1 3952124 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514269.1 1560132 R 376619 CDS YP_514270.1 89256908 3952743 complement(1561074..1562108) 1 NC_007880.1 hypothetical protein 1562108 3952743 FTL_1631 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514270.1 1561074 R 376619 CDS YP_514271.1 89256909 3952744 complement(1562127..1562375) 1 NC_007880.1 hypothetical protein 1562375 3952744 FTL_1632 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514271.1 1562127 R 376619 CDS YP_514272.1 89256910 3952745 complement(1562442..1563167) 1 NC_007880.1 hypothetical protein 1563167 3952745 FTL_1633 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514272.1 1562442 R 376619 CDS YP_514273.1 89256911 3952746 complement(1563348..1564340) 1 NC_007880.1 LysR family transcriptional regulator 1564340 3952746 FTL_1634 Francisella tularensis subsp. holarctica LVS LysR family transcriptional regulator YP_514273.1 1563348 R 376619 CDS YP_514274.1 89256912 3952747 1564878..1566992 1 NC_007880.1 chitinase, fragment 1566992 3952747 FTL_1635 Francisella tularensis subsp. holarctica LVS chitinase, fragment YP_514274.1 1564878 D 376619 CDS YP_514275.1 89256913 3952748 1566967..1567161 1 NC_007880.1 hypothetical protein 1567161 3952748 FTL_1636 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514275.1 1566967 D 376619 CDS YP_514276.1 89256914 3952749 complement(1568349..1569383) 1 NC_007880.1 lipoprotein 1569383 3952749 FTL_1637 Francisella tularensis subsp. holarctica LVS lipoprotein YP_514276.1 1568349 R 376619 CDS YP_514277.1 89256915 3952750 1569510..1570205 1 NC_007880.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 1570205 3952750 FTL_1638 Francisella tularensis subsp. holarctica LVS 3-demethylubiquinone-9 3-methyltransferase YP_514277.1 1569510 D 376619 CDS YP_514278.1 89256916 3952751 1570208..1570951 1 NC_007880.1 hypothetical protein 1570951 3952751 FTL_1639 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514278.1 1570208 D 376619 CDS YP_514279.1 89256917 3952752 1571317..1572819 1 NC_007880.1 amino acid transporter protein, fragment 1572819 3952752 FTL_1640 Francisella tularensis subsp. holarctica LVS amino acid transporter protein, fragment YP_514279.1 1571317 D 376619 CDS YP_514280.1 89256918 3952753 1572832..1573113 1 NC_007880.1 hypothetical protein 1573113 3952753 FTL_1641 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514280.1 1572832 D 376619 CDS YP_514281.1 89256919 3952754 complement(1573127..1573366) 1 NC_007880.1 hypothetical protein 1573366 3952754 FTL_1642 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514281.1 1573127 R 376619 CDS YP_514282.1 89256920 3952125 join(1573357..1573683,1573683..1574237) 1 NC_007880.1 transposase 1574237 isftu1 3952125 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514282.1 1573357 D 376619 CDS YP_514283.1 89256921 3952755 complement(1574234..1575742) 1 NC_007880.1 glycerol kinase 1575742 3952755 FTL_1644 Francisella tularensis subsp. holarctica LVS glycerol kinase YP_514283.1 1574234 R 376619 CDS YP_514284.1 89256922 3952756 complement(1575811..1577022) 1 NC_007880.1 major facilitator transporter 1577022 3952756 FTL_1645 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514284.1 1575811 R 376619 CDS YP_514285.1 89256923 3952757 complement(1577182..1577793) 1 NC_007880.1 hypothetical protein 1577793 3952757 FTL_1646 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514285.1 1577182 R 376619 CDS YP_514286.1 89256924 3952758 1577927..1579129 1 NC_007880.1 major facilitator transporter 1579129 3952758 FTL_1647 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514286.1 1577927 D 376619 CDS YP_514287.1 89256925 3952759 complement(1579298..1580101) 1 NC_007880.1 oligopeptide transporter, subunit D, ABC transporter ATP-binding protein 1580101 3952759 FTL_1648 Francisella tularensis subsp. holarctica LVS oligopeptide transporter, subunit D, ABC transporter ATP-binding protein YP_514287.1 1579298 R 376619 CDS YP_514288.1 89256926 3951432 complement(1581927..1582250) 1 NC_007880.1 peptide transport system substrate-binding protein 1582250 3951432 FTL_1653 Francisella tularensis subsp. holarctica LVS peptide transport system substrate-binding protein YP_514288.1 1581927 R 376619 CDS YP_514289.1 89256927 3951433 complement(1582344..1583603) 1 NC_007880.1 hypothetical protein 1583603 3951433 FTL_1654 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514289.1 1582344 R 376619 CDS YP_514290.1 89256928 3952365 complement(1583637..1584260) 1 NC_007880.1 transposase 1584260 isftu2 3952365 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_514290.1 1583637 R 376619 CDS YP_514291.1 89256929 3951434 complement(1584551..1586773) 1 NC_007880.1 DNA helicase II 1586773 3951434 FTL_1656 Francisella tularensis subsp. holarctica LVS DNA helicase II YP_514291.1 1584551 R 376619 CDS YP_514292.1 89256930 3951435 complement(1586864..1587859) 1 NC_007880.1 signal recognition particle receptor FtsY 1587859 3951435 FTL_1657 Francisella tularensis subsp. holarctica LVS signal recognition particle receptor FtsY YP_514292.1 1586864 R 376619 CDS YP_514293.1 89256931 3951436 complement(1587892..1589208) 1 NC_007880.1 hypothetical protein 1589208 3951436 FTL_1658 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514293.1 1587892 R 376619 CDS YP_514294.1 89256932 3951437 complement(1589283..1590860) 1 NC_007880.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 1590860 prfC 3951437 prfC Francisella tularensis subsp. holarctica LVS peptide chain release factor 3 YP_514294.1 1589283 R 376619 CDS YP_514295.1 89256933 3951438 complement(1590922..1591551) 1 NC_007880.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1591551 tmk 3951438 tmk Francisella tularensis subsp. holarctica LVS thymidylate kinase YP_514295.1 1590922 R 376619 CDS YP_514296.1 89256934 3951439 complement(1591564..1592766) 1 NC_007880.1 nucleoside permease NUP family protein 1592766 3951439 FTL_1661 Francisella tularensis subsp. holarctica LVS nucleoside permease NUP family protein YP_514296.1 1591564 R 376619 CDS YP_514297.1 89256935 3951440 complement(1592785..1593984) 1 NC_007880.1 nucleoside permease NUP family protein 1593984 3951440 FTL_1662 Francisella tularensis subsp. holarctica LVS nucleoside permease NUP family protein YP_514297.1 1592785 R 376619 CDS YP_514298.1 89256936 3951441 complement(1593974..1594708) 1 NC_007880.1 deoxyribose-phosphate aldolase 1594708 3951441 FTL_1663 Francisella tularensis subsp. holarctica LVS deoxyribose-phosphate aldolase YP_514298.1 1593974 R 376619 CDS YP_514299.1 89256937 3951442 complement(1594698..1595942) 1 NC_007880.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 1595942 3951442 FTL_1664 Francisella tularensis subsp. holarctica LVS phosphopentomutase YP_514299.1 1594698 R 376619 CDS YP_514300.1 89256938 3951443 complement(1595947..1596711) 1 NC_007880.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 1596711 3951443 FTL_1665 Francisella tularensis subsp. holarctica LVS pantothenate kinase YP_514300.1 1595947 R 376619 CDS YP_514301.1 89256939 3951444 complement(1596731..1599424) 1 NC_007880.1 DNA polymerase I 1599424 3951444 FTL_1666 Francisella tularensis subsp. holarctica LVS DNA polymerase I YP_514301.1 1596731 R 376619 CDS YP_514302.1 89256940 3951445 complement(1599520..1600488) 1 NC_007880.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 1600488 lpxK 3951445 lpxK Francisella tularensis subsp. holarctica LVS tetraacyldisaccharide 4'-kinase YP_514302.1 1599520 R 376619 CDS YP_514303.1 89256941 3951446 complement(1600494..1602323) 1 NC_007880.1 lipid A transport protein ABC transporter ATP-binding protein/permease 1602323 3951446 FTL_1668 Francisella tularensis subsp. holarctica LVS lipid A transport protein ABC transporter ATP-binding protein/permease YP_514303.1 1600494 R 376619 CDS YP_514304.1 89256942 3951447 1602428..1603510 1 NC_007880.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 1603510 3951447 FTL_1669 Francisella tularensis subsp. holarctica LVS tRNA CCA-pyrophosphorylase YP_514304.1 1602428 D 376619 CDS YP_514305.1 89256943 3950920 1603550..1604041 1 NC_007880.1 disulfide bond formation protein 1604041 3950920 FTL_1670 Francisella tularensis subsp. holarctica LVS disulfide bond formation protein YP_514305.1 1603550 D 376619 CDS YP_514306.1 89256944 3950921 1604054..1605427 1 NC_007880.1 RND efflux transporter 1605427 3950921 FTL_1671 Francisella tularensis subsp. holarctica LVS RND efflux transporter YP_514306.1 1604054 D 376619 CDS YP_514307.1 89256945 3950922 1605427..1608540 1 NC_007880.1 AcrB/AcrD/AcrF family transporter 1608540 3950922 FTL_1672 Francisella tularensis subsp. holarctica LVS AcrB/AcrD/AcrF family transporter YP_514307.1 1605427 D 376619 CDS YP_514308.1 89256946 3950923 1608672..1609952 1 NC_007880.1 major facilitator transporter 1609952 3950923 FTL_1673 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514308.1 1608672 D 376619 CDS YP_514309.1 89256947 3950924 1610197..1610778 1 NC_007880.1 hypothetical protein 1610778 3950924 FTL_1674 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514309.1 1610197 D 376619 CDS YP_514310.1 89256948 3950928 complement(1612224..1613237) 1 NC_007880.1 hypothetical protein 1613237 3950928 FTL_1678 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514310.1 1612224 R 376619 CDS YP_514311.1 89256949 3950929 complement(1613466..1613792) 1 NC_007880.1 transposase 1613792 3950929 FTL_1679 Francisella tularensis subsp. holarctica LVS transposase YP_514311.1 1613466 R 376619 CDS YP_514312.1 89256950 3952366 complement(1613845..1614498) 1 NC_007880.1 transposase 1614498 isftu2 3952366 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_514312.1 1613845 R 376619 CDS YP_514313.1 89256951 3952126 join(1614803..1615127,1615127..1615683) 1 NC_007880.1 transposase 1615683 isftu1 3952126 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514313.1 1614803 D 376619 CDS YP_514314.1 89256952 3950930 1615735..1615986 1 NC_007880.1 hypothetical protein 1615986 3950930 FTL_1682 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514314.1 1615735 D 376619 CDS YP_514315.1 89256953 3950931 1616054..1617448 1 NC_007880.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1617448 cysS 3950931 cysS Francisella tularensis subsp. holarctica LVS cysteinyl-tRNA synthetase YP_514315.1 1616054 D 376619 CDS YP_514316.1 89256954 3950932 1617452..1618396 1 NC_007880.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1618396 3950932 FTL_1684 Francisella tularensis subsp. holarctica LVS N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_514316.1 1617452 D 376619 CDS YP_514317.1 89256955 3950933 1618452..1619639 1 NC_007880.1 major facilitator transporter 1619639 3950933 FTL_1685 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514317.1 1618452 D 376619 CDS YP_514318.1 89256956 3950934 1619653..1620144 1 NC_007880.1 acetyltransferase 1620144 3950934 FTL_1686 Francisella tularensis subsp. holarctica LVS acetyltransferase YP_514318.1 1619653 D 376619 CDS YP_514319.1 89256957 3952127 join(1620290..1620616,1620616..1621170) 1 NC_007880.1 transposase 1621170 isftu1 3952127 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514319.1 1620290 D 376619 CDS YP_514320.1 89256958 3950936 complement(1621483..1622334) 1 NC_007880.1 hypothetical protein 1622334 3950936 FTL_1689 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514320.1 1621483 R 376619 CDS YP_514321.1 89256959 3950937 complement(1622338..1623267) 1 NC_007880.1 hypothetical protein 1623267 3950937 FTL_1690 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514321.1 1622338 R 376619 CDS YP_514322.1 89256960 3950938 complement(1623286..1623522) 1 NC_007880.1 hypothetical protein 1623522 3950938 FTL_1691 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514322.1 1623286 R 376619 CDS YP_514323.1 89256961 3950939 complement(1623673..1623951) 1 NC_007880.1 hypothetical protein 1623951 3950939 FTL_1692 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514323.1 1623673 R 376619 CDS YP_514324.1 89256962 3952170 complement(1624106..1624579) 1 NC_007880.1 hypothetical protein 1624579 3952170 FTL_1693 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514324.1 1624106 R 376619 CDS YP_514325.1 89256963 3952171 complement(1624787..1625977) 1 NC_007880.1 hypothetical protein 1625977 3952171 FTL_1694 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514325.1 1624787 R 376619 CDS YP_514326.1 89256964 3952172 complement(1625974..1626777) 1 NC_007880.1 hypothetical protein 1626777 3952172 FTL_1695 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514326.1 1625974 R 376619 CDS YP_514327.1 89256965 3952173 complement(1626761..1627108) 1 NC_007880.1 hypothetical protein 1627108 3952173 FTL_1696 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514327.1 1626761 R 376619 CDS YP_514328.1 89256966 3952174 complement(1627179..1627643) 1 NC_007880.1 metal ion transporter 1627643 3952174 FTL_1697 Francisella tularensis subsp. holarctica LVS metal ion transporter YP_514328.1 1627179 R 376619 CDS YP_514329.1 89256967 3952175 complement(1627888..1628217) 1 NC_007880.1 hypothetical protein 1628217 3952175 FTL_1698 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514329.1 1627888 R 376619 CDS YP_514330.1 89256968 3952176 complement(1628490..1630085) 1 NC_007880.1 hypothetical protein 1630085 3952176 FTL_1699 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514330.1 1628490 R 376619 CDS YP_514331.1 89256969 3952177 complement(1630240..1631706) 1 NC_007880.1 Sodium/proline permease 1631706 3952177 FTL_1700 Francisella tularensis subsp. holarctica LVS Sodium/proline permease YP_514331.1 1630240 R 376619 CDS YP_514332.1 89256970 3952178 complement(1632013..1632999) 1 NC_007880.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 1632999 glpX 3952178 glpX Francisella tularensis subsp. holarctica LVS fructose 1,6-bisphosphatase II YP_514332.1 1632013 R 376619 CDS YP_514333.1 89256971 3952179 complement(1633019..1633657) 1 NC_007880.1 hypothetical protein 1633657 3952179 FTL_1702 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514333.1 1633019 R 376619 CDS YP_514334.1 89256972 3952180 complement(1633666..1635120) 1 NC_007880.1 amino acid transporter 1635120 3952180 FTL_1703 Francisella tularensis subsp. holarctica LVS amino acid transporter YP_514334.1 1633666 R 376619 CDS YP_514335.1 89256973 3952181 complement(1635367..1636035) 1 NC_007880.1 hypothetical protein 1636035 3952181 FTL_1704 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514335.1 1635367 R 376619 CDS YP_514336.1 89256974 3952182 1636157..1638658 1 NC_007880.1 cell division protein 1638658 3952182 FTL_1705 Francisella tularensis subsp. holarctica LVS cell division protein YP_514336.1 1636157 D 376619 CDS YP_514337.1 89256975 3952183 1638659..1639276 1 NC_007880.1 lipoprotein releasing system subunit A, outer membrane lipoproteins carrier 1639276 3952183 FTL_1706 Francisella tularensis subsp. holarctica LVS lipoprotein releasing system subunit A, outer membrane lipoproteins carrier YP_514337.1 1638659 D 376619 CDS YP_514338.1 89256976 3952184 complement(1639670..1639873) 1 NC_007880.1 hypothetical protein 1639873 3952184 FTL_1707 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514338.1 1639670 R 376619 CDS YP_514339.1 89256977 3952185 1639985..1641439 1 NC_007880.1 potassium uptake protein 1641439 3952185 FTL_1708 Francisella tularensis subsp. holarctica LVS potassium uptake protein YP_514339.1 1639985 D 376619 CDS YP_514340.1 89256978 3952186 complement(1641454..1641942) 1 NC_007880.1 hypothetical protein 1641942 3952186 FTL_1709 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514340.1 1641454 R 376619 CDS YP_514341.1 89256979 3952187 complement(1642022..1642723) 1 NC_007880.1 ProP osmoprotectant transporter, fragment 1642723 3952187 FTL_1710 Francisella tularensis subsp. holarctica LVS ProP osmoprotectant transporter, fragment YP_514341.1 1642022 R 376619 CDS YP_514342.1 89256980 3952188 complement(1643127..1643675) 1 NC_007880.1 HsdR protein, fragment 1643675 3952188 FTL_1711 Francisella tularensis subsp. holarctica LVS HsdR protein, fragment YP_514342.1 1643127 R 376619 CDS YP_514343.1 89256981 3951565 complement(1643645..1644412) 1 NC_007880.1 HsdR protein, fragment 1644412 3951565 FTL_1712 Francisella tularensis subsp. holarctica LVS HsdR protein, fragment YP_514343.1 1643645 R 376619 CDS YP_514344.1 89256982 3952128 join(1644403..1644727,1644727..1645283) 1 NC_007880.1 transposase 1645283 isftu1 3952128 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514344.1 1644403 D 376619 CDS YP_514345.1 89256983 3951566 complement(1645403..1647037) 1 NC_007880.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 1647037 groEL 3951566 groEL Francisella tularensis subsp. holarctica LVS chaperonin GroEL YP_514345.1 1645403 R 376619 CDS YP_514346.1 89256984 3951567 complement(1647075..1647362) 1 NC_007880.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1647362 groES 3951567 groES Francisella tularensis subsp. holarctica LVS co-chaperonin GroES YP_514346.1 1647075 R 376619 CDS YP_514347.1 89256985 3951568 1647620..1648039 1 NC_007880.1 hypothetical protein 1648039 3951568 FTL_1716 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514347.1 1647620 D 376619 CDS YP_514348.1 89256986 3951569 1648650..1649444 1 NC_007880.1 hypothetical protein 1649444 3951569 FTL_1717 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514348.1 1648650 D 376619 CDS YP_514349.1 89256987 3952129 complement(join(1649495..1650049,1650049..1650375)) 1 NC_007880.1 transposase 1650375 isftu1 3952129 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514349.1 1649495 R 376619 CDS YP_514350.1 89256988 3951570 1650366..1650866 1 NC_007880.1 hypothetical protein 1650866 3951570 FTL_1719 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514350.1 1650366 D 376619 CDS YP_514351.1 89256989 3951571 complement(1650857..1651711) 1 NC_007880.1 modification methylase 1651711 3951571 FTL_1720 Francisella tularensis subsp. holarctica LVS modification methylase YP_514351.1 1650857 R 376619 CDS YP_514352.1 89256990 3951572 complement(1651704..1652789) 1 NC_007880.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1652789 prfA 3951572 prfA Francisella tularensis subsp. holarctica LVS peptide chain release factor 1 YP_514352.1 1651704 R 376619 CDS YP_514353.1 89256991 3951573 complement(1652790..1654034) 1 NC_007880.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1654034 3951573 FTL_1722 Francisella tularensis subsp. holarctica LVS glutamyl-tRNA reductase YP_514353.1 1652790 R 376619 CDS YP_514354.1 89256992 3951574 1654214..1654852 1 NC_007880.1 hypothetical protein 1654852 3951574 FTL_1723 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514354.1 1654214 D 376619 CDS YP_514355.1 89256993 3951575 1654855..1656225 1 NC_007880.1 lipoprotein 1656225 3951575 FTL_1724 Francisella tularensis subsp. holarctica LVS lipoprotein YP_514355.1 1654855 D 376619 CDS YP_514356.1 89256994 3951576 1656225..1657406 1 NC_007880.1 eflux protein 1657406 3951576 FTL_1725 Francisella tularensis subsp. holarctica LVS eflux protein YP_514356.1 1656225 D 376619 CDS YP_514357.1 89256995 3951577 1657496..1659379 1 NC_007880.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 1659379 3951577 FTL_1726 Francisella tularensis subsp. holarctica LVS DNA topoisomerase IV subunit B YP_514357.1 1657496 D 376619 CDS YP_514358.1 89256996 3951578 complement(1659427..1659951) 1 NC_007880.1 N-acetyl-anhydromuranmyl-L-alanine amidase 1659951 3951578 FTL_1727 Francisella tularensis subsp. holarctica LVS N-acetyl-anhydromuranmyl-L-alanine amidase YP_514358.1 1659427 R 376619 CDS YP_514359.1 89256997 3951579 1660025..1660651 1 NC_007880.1 PAP2 family protein 1660651 3951579 FTL_1728 Francisella tularensis subsp. holarctica LVS PAP2 family protein YP_514359.1 1660025 D 376619 CDS YP_514360.1 89256998 3951580 complement(1660661..1661128) 1 NC_007880.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 1661128 3951580 FTL_1729 Francisella tularensis subsp. holarctica LVS dinucleoside polyphosphate hydrolase YP_514360.1 1660661 R 376619 CDS YP_514361.1 89256999 3951581 1661567..1662814 1 NC_007880.1 hypothetical protein 1662814 3951581 FTL_1730 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514361.1 1661567 D 376619 CDS YP_514362.1 89257000 3951582 1662932..1663816 1 NC_007880.1 licB-like transmembrane protein 1663816 3951582 FTL_1731 Francisella tularensis subsp. holarctica LVS licB-like transmembrane protein YP_514362.1 1662932 D 376619 CDS YP_514363.1 89257001 3951583 complement(1663813..1664397) 1 NC_007880.1 acid phosphatase 1664397 3951583 FTL_1732 Francisella tularensis subsp. holarctica LVS acid phosphatase YP_514363.1 1663813 R 376619 CDS YP_514364.1 89257002 3951584 complement(1664402..1665247) 1 NC_007880.1 oxidoreductase iron/ascorbate family protein 1665247 3951584 FTL_1733 Francisella tularensis subsp. holarctica LVS oxidoreductase iron/ascorbate family protein YP_514364.1 1664402 R 376619 CDS YP_514365.1 89257003 3951391 complement(1665370..1666248) 1 NC_007880.1 integrase/recombinase 1666248 3951391 FTL_1734 Francisella tularensis subsp. holarctica LVS integrase/recombinase YP_514365.1 1665370 R 376619 CDS YP_514366.1 89257004 3951392 complement(1666414..1666761) 1 NC_007880.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1666761 rplS 3951392 rplS Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L19 YP_514366.1 1666414 R 376619 CDS YP_514367.1 89257005 3951393 complement(1666761..1667519) 1 NC_007880.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 1667519 trmD 3951393 trmD Francisella tularensis subsp. holarctica LVS tRNA (guanine-N(1)-)-methyltransferase YP_514367.1 1666761 R 376619 CDS YP_514368.1 89257006 3951394 complement(1667922..1668431) 1 NC_007880.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 1668431 rimM 3951394 rimM Francisella tularensis subsp. holarctica LVS 16S rRNA-processing protein RimM YP_514368.1 1667922 R 376619 CDS YP_514369.1 89257007 3951395 complement(1668474..1668722) 1 NC_007880.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 1668722 rpsP 3951395 rpsP Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S16 YP_514369.1 1668474 R 376619 CDS YP_514370.1 89257008 3951396 1669016..1670176 1 NC_007880.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1670176 3951396 FTL_1739 Francisella tularensis subsp. holarctica LVS S-adenosylmethionine synthetase YP_514370.1 1669016 D 376619 CDS YP_514371.1 89257009 3951397 complement(1670388..1671554) 1 NC_007880.1 fatty acid desaturase 1671554 3951397 FTL_1740 Francisella tularensis subsp. holarctica LVS fatty acid desaturase YP_514371.1 1670388 R 376619 CDS YP_514372.1 89257010 3951398 complement(1671668..1672678) 1 NC_007880.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 1672678 3951398 FTL_1741 Francisella tularensis subsp. holarctica LVS putative DNA-binding/iron metalloprotein/AP endonuclease YP_514372.1 1671668 R 376619 CDS YP_514373.1 89257011 3951399 complement(1672678..1672914) 1 NC_007880.1 hypothetical protein 1672914 3951399 FTL_1742 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514373.1 1672678 R 376619 CDS YP_514374.1 89257012 3951400 complement(1673017..1677270) 1 NC_007880.1 DNA-directed RNA polymerase subunit beta 1677270 3951400 FTL_1743 Francisella tularensis subsp. holarctica LVS DNA-directed RNA polymerase subunit beta YP_514374.1 1673017 R 376619 CDS YP_514375.1 89257013 3951401 complement(1677332..1681408) 1 NC_007880.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1681408 rpoB 3951401 rpoB Francisella tularensis subsp. holarctica LVS DNA-directed RNA polymerase subunit beta YP_514375.1 1677332 R 376619 CDS YP_514376.1 89257014 3951402 complement(1681562..1681939) 1 NC_007880.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1681939 rplL 3951402 rplL Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L7/L12 YP_514376.1 1681562 R 376619 CDS YP_514377.1 89257015 3951403 complement(1682001..1682519) 1 NC_007880.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1682519 rplJ 3951403 rplJ Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L10 YP_514377.1 1682001 R 376619 CDS YP_514378.1 89257016 3951404 complement(1682689..1683387) 1 NC_007880.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 1683387 rplA 3951404 rplA Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L1 YP_514378.1 1682689 R 376619 CDS YP_514379.1 89257017 3951405 complement(1683387..1683821) 1 NC_007880.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 1683821 rplK 3951405 rplK Francisella tularensis subsp. holarctica LVS 50S ribosomal protein L11 YP_514379.1 1683387 R 376619 CDS YP_514380.1 89257018 3951406 complement(1683890..1684423) 1 NC_007880.1 transcription antitermination protein nusG 1684423 3951406 FTL_1749 Francisella tularensis subsp. holarctica LVS transcription antitermination protein nusG YP_514380.1 1683890 R 376619 CDS YP_514381.2 161353779 3951407 complement(1684439..1684909) 1 NC_007880.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1684909 secE 3951407 secE Francisella tularensis subsp. holarctica LVS preprotein translocase subunit SecE YP_514381.2 1684439 R 376619 CDS YP_514382.1 89257020 3951408 complement(1685101..1686285) 1 NC_007880.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1686285 3951408 FTL_1751 Francisella tularensis subsp. holarctica LVS elongation factor Tu YP_514382.1 1685101 R 376619 CDS YP_514383.1 89257021 3951409 complement(1686750..1687997) 1 NC_007880.1 helicase 1687997 3951409 FTL_1752 Francisella tularensis subsp. holarctica LVS helicase YP_514383.1 1686750 R 376619 CDS YP_514384.1 89257022 3951878 complement(1688164..1688661) 1 NC_007880.1 ion channel protein, fragment 1688661 3951878 FTL_1753 Francisella tularensis subsp. holarctica LVS ion channel protein, fragment YP_514384.1 1688164 R 376619 CDS YP_514385.1 89257023 3951879 complement(1688639..1689352) 1 NC_007880.1 hypothetical protein 1689352 3951879 FTL_1754 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514385.1 1688639 R 376619 CDS YP_514386.1 89257024 3951880 complement(1689356..1690120) 1 NC_007880.1 glycerol uptake facilitator protein 1690120 3951880 FTL_1755 Francisella tularensis subsp. holarctica LVS glycerol uptake facilitator protein YP_514386.1 1689356 R 376619 CDS YP_514387.1 89257025 3951881 complement(1690130..1691662) 1 NC_007880.1 anaerobic glycerol-3-phosphate dehydrogenase 1691662 3951881 FTL_1756 Francisella tularensis subsp. holarctica LVS anaerobic glycerol-3-phosphate dehydrogenase YP_514387.1 1690130 R 376619 CDS YP_514388.1 89257026 3952130 join(1691978..1692302,1692302..1692858) 1 NC_007880.1 transposase 1692858 isftu1 3952130 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514388.1 1691978 D 376619 CDS YP_514389.1 89257027 3951882 complement(1692836..1693120) 1 NC_007880.1 hypothetical protein 1693120 3951882 FTL_1758 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514389.1 1692836 R 376619 CDS YP_514390.1 89257028 3951883 complement(1693508..1694788) 1 NC_007880.1 hypothetical protein 1694788 3951883 FTL_1759 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514390.1 1693508 R 376619 CDS YP_514391.1 89257029 3951884 complement(1694792..1695319) 1 NC_007880.1 hypothetical protein 1695319 3951884 FTL_1760 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514391.1 1694792 R 376619 CDS YP_514392.1 89257030 3951885 complement(1695347..1695682) 1 NC_007880.1 hypothetical protein 1695682 3951885 FTL_1761 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514392.1 1695347 R 376619 CDS YP_514393.1 89257031 3951886 1695821..1697248 1 NC_007880.1 sensor histidine kinase 1697248 3951886 FTL_1762 Francisella tularensis subsp. holarctica LVS sensor histidine kinase YP_514393.1 1695821 D 376619 CDS YP_514394.1 89257032 3951887 complement(1697245..1698126) 1 NC_007880.1 hypothetical protein 1698126 3951887 FTL_1763 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514394.1 1697245 R 376619 CDS YP_514395.1 89257033 3951889 1699742..1700704 1 NC_007880.1 cytochrome oxidase bd-II subunit II 1700704 3951889 FTL_1765 Francisella tularensis subsp. holarctica LVS cytochrome oxidase bd-II subunit II YP_514395.1 1699742 D 376619 CDS YP_514396.1 89257034 3951890 1700715..1701149 1 NC_007880.1 hypothetical protein 1701149 3951890 FTL_1766 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514396.1 1700715 D 376619 CDS YP_514397.1 89257035 3951894 complement(1702224..1702832) 1 NC_007880.1 Type IV pili nucleotide-binding protein 1702832 3951894 FTL_1770 Francisella tularensis subsp. holarctica LVS Type IV pili nucleotide-binding protein YP_514397.1 1702224 R 376619 CDS YP_514398.1 89257036 3951895 complement(1702893..1703252) 1 NC_007880.1 twitching motility protein PilT 1703252 3951895 FTL_1771 Francisella tularensis subsp. holarctica LVS twitching motility protein PilT YP_514398.1 1702893 R 376619 CDS YP_514399.1 89257037 3951896 complement(1703346..1706159) 1 NC_007880.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1706159 3951896 FTL_1772 Francisella tularensis subsp. holarctica LVS aconitate hydratase YP_514399.1 1703346 R 376619 CDS YP_514400.1 89257038 3951897 complement(1706264..1707049) 1 NC_007880.1 hypothetical protein 1707049 3951897 FTL_1773 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514400.1 1706264 R 376619 CDS YP_514401.1 89257039 3952761 1707119..1707496 1 NC_007880.1 hypothetical protein 1707496 3952761 FTL_1774 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514401.1 1707119 D 376619 CDS YP_514402.1 89257040 3952762 1707501..1708643 1 NC_007880.1 oxygen-independent coproporphyrinogen III oxidase 1708643 3952762 FTL_1775 Francisella tularensis subsp. holarctica LVS oxygen-independent coproporphyrinogen III oxidase YP_514402.1 1707501 D 376619 CDS YP_514403.1 89257041 3952763 complement(1708640..1709092) 1 NC_007880.1 hypothetical protein 1709092 3952763 FTL_1776 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514403.1 1708640 R 376619 CDS YP_514404.1 89257042 3952766 complement(1710322..1710675) 1 NC_007880.1 preprotein translocase subunit SecG 1710675 secG 3952766 secG Francisella tularensis subsp. holarctica LVS preprotein translocase subunit SecG YP_514404.1 1710322 R 376619 CDS YP_514405.1 89257043 3952767 complement(1710663..1711424) 1 NC_007880.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1711424 3952767 FTL_1780 Francisella tularensis subsp. holarctica LVS triosephosphate isomerase YP_514405.1 1710663 R 376619 CDS YP_514406.1 89257044 3952768 complement(1711427..1712758) 1 NC_007880.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1712758 glmM 3952768 glmM Francisella tularensis subsp. holarctica LVS phosphoglucosamine mutase YP_514406.1 1711427 R 376619 CDS YP_514407.1 89257045 3952769 complement(1712769..1713296) 1 NC_007880.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1713296 3952769 FTL_1782 Francisella tularensis subsp. holarctica LVS adenine phosphoribosyltransferase YP_514407.1 1712769 R 376619 CDS YP_514408.1 89257046 3952770 complement(1713336..1714805) 1 NC_007880.1 dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1714805 3952770 FTL_1783 Francisella tularensis subsp. holarctica LVS dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex YP_514408.1 1713336 R 376619 CDS YP_514409.1 89257047 3952771 complement(1714831..1717644) 1 NC_007880.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 1717644 sucA 3952771 sucA Francisella tularensis subsp. holarctica LVS 2-oxoglutarate dehydrogenase E1 component YP_514409.1 1714831 R 376619 CDS YP_514410.1 89257048 3952772 complement(1717674..1718375) 1 NC_007880.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 1718375 sdhB 3952772 sdhB Francisella tularensis subsp. holarctica LVS succinate dehydrogenase iron-sulfur subunit YP_514410.1 1717674 R 376619 CDS YP_514411.1 89257049 3952773 complement(1718393..1720186) 1 NC_007880.1 succinate dehydrogenase, catalytic and NAD/flavoprotein subunit 1720186 3952773 FTL_1786 Francisella tularensis subsp. holarctica LVS succinate dehydrogenase, catalytic and NAD/flavoprotein subunit YP_514411.1 1718393 R 376619 CDS YP_514412.1 89257050 3952774 complement(1720199..1720567) 1 NC_007880.1 succinate dehydrogenase hydrophobic membrane anchor protein 1720567 3952774 FTL_1787 Francisella tularensis subsp. holarctica LVS succinate dehydrogenase hydrophobic membrane anchor protein YP_514412.1 1720199 R 376619 CDS YP_514413.1 89257051 3952775 complement(1720543..1720932) 1 NC_007880.1 succinate dehydrogenase, cytochrome b556 1720932 3952775 FTL_1788 Francisella tularensis subsp. holarctica LVS succinate dehydrogenase, cytochrome b556 YP_514413.1 1720543 R 376619 CDS YP_514414.1 89257052 3952776 1721274..1722533 1 NC_007880.1 citrate synthase 1722533 3952776 FTL_1789 Francisella tularensis subsp. holarctica LVS citrate synthase YP_514414.1 1721274 D 376619 CDS YP_514415.1 89257053 3952777 1722622..1723887 1 NC_007880.1 major facilitator superfamily transporter 1723887 3952777 FTL_1790 Francisella tularensis subsp. holarctica LVS major facilitator superfamily transporter YP_514415.1 1722622 D 376619 CDS YP_514416.1 89257054 3952778 complement(1724094..1724672) 1 NC_007880.1 Fe; superoxide dismutase 1724672 3952778 FTL_1791 Francisella tularensis subsp. holarctica LVS superoxide dismutase YP_514416.1 1724094 R 376619 CDS YP_514417.1 89257055 3952779 1724808..1725137 1 NC_007880.1 glutaredoxin-like protein 1725137 3952779 FTL_1792 Francisella tularensis subsp. holarctica LVS glutaredoxin-like protein YP_514417.1 1724808 D 376619 CDS YP_514418.1 89257056 3951858 complement(1725154..1727997) 1 NC_007880.1 hypothetical protein 1727997 3951858 FTL_1793 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514418.1 1725154 R 376619 CDS YP_514419.1 89257057 3951859 complement(1728208..1728645) 1 NC_007880.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit epsilon 1728645 atpC 3951859 atpC Francisella tularensis subsp. holarctica LVS F0F1 ATP synthase subunit epsilon YP_514419.1 1728208 R 376619 CDS YP_514420.1 89257058 3951860 complement(1728658..1730034) 1 NC_007880.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 1730034 3951860 FTL_1795 Francisella tularensis subsp. holarctica LVS F0F1 ATP synthase subunit beta YP_514420.1 1728658 R 376619 CDS YP_514421.1 89257059 3951861 complement(1730044..1730940) 1 NC_007880.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 1730940 3951861 FTL_1796 Francisella tularensis subsp. holarctica LVS F0F1 ATP synthase subunit gamma YP_514421.1 1730044 R 376619 CDS YP_514422.1 89257060 3951862 complement(1730955..1732496) 1 NC_007880.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 1732496 3951862 FTL_1797 Francisella tularensis subsp. holarctica LVS F0F1 ATP synthase subunit alpha YP_514422.1 1730955 R 376619 CDS YP_514423.1 89257061 3951863 complement(1732515..1733039) 1 NC_007880.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 1733039 3951863 FTL_1798 Francisella tularensis subsp. holarctica LVS F0F1 ATP synthase subunit delta YP_514423.1 1732515 R 376619 CDS YP_514424.1 89257062 3951864 complement(1733059..1733529) 1 NC_007880.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 1733529 3951864 FTL_1799 Francisella tularensis subsp. holarctica LVS F0F1 ATP synthase subunit B YP_514424.1 1733059 R 376619 CDS YP_514425.1 89257063 3951865 complement(1733575..1733880) 1 NC_007880.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 1733880 3951865 FTL_1800 Francisella tularensis subsp. holarctica LVS F0F1 ATP synthase subunit C YP_514425.1 1733575 R 376619 CDS YP_514426.1 89257064 3951866 complement(1733931..1734722) 1 NC_007880.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 1734722 3951866 FTL_1801 Francisella tularensis subsp. holarctica LVS F0F1 ATP synthase subunit A YP_514426.1 1733931 R 376619 CDS YP_514427.1 89257065 3951867 complement(1734775..1735206) 1 NC_007880.1 hypothetical protein 1735206 3951867 FTL_1802 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514427.1 1734775 R 376619 CDS YP_514428.1 89257066 3951868 1735283..1736587 1 NC_007880.1 major facilitator transporter 1736587 3951868 FTL_1803 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514428.1 1735283 D 376619 CDS YP_514429.1 89257067 3951869 complement(1736589..1737518) 1 NC_007880.1 ribosomal large subunit pseudouridine synthase C 1737518 3951869 FTL_1804 Francisella tularensis subsp. holarctica LVS ribosomal large subunit pseudouridine synthase C YP_514429.1 1736589 R 376619 CDS YP_514430.1 89257068 3951870 complement(1737511..1738578) 1 NC_007880.1 ATPase 1738578 3951870 FTL_1805 Francisella tularensis subsp. holarctica LVS ATPase YP_514430.1 1737511 R 376619 CDS YP_514431.1 89257069 3951871 complement(1738581..1739879) 1 NC_007880.1 major facilitator transporter 1739879 3951871 FTL_1806 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514431.1 1738581 R 376619 CDS YP_514432.1 89257070 3951872 complement(1739886..1741151) 1 NC_007880.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 1741151 hisS 3951872 hisS Francisella tularensis subsp. holarctica LVS histidyl-tRNA synthetase YP_514432.1 1739886 R 376619 CDS YP_514433.1 89257071 3951873 complement(1741159..1741590) 1 NC_007880.1 ribosome-binding factor A 1741590 3951873 FTL_1808 Francisella tularensis subsp. holarctica LVS ribosome-binding factor A YP_514433.1 1741159 R 376619 CDS YP_514434.1 89257072 3951874 complement(1741593..1744133) 1 NC_007880.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1744133 infB 3951874 infB Francisella tularensis subsp. holarctica LVS translation initiation factor IF-2 YP_514434.1 1741593 R 376619 CDS YP_514435.1 89257073 3951875 complement(1744172..1745641) 1 NC_007880.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 1745641 nusA 3951875 nusA Francisella tularensis subsp. holarctica LVS transcription elongation factor NusA YP_514435.1 1744172 R 376619 CDS YP_514436.1 89257074 3951876 complement(1745659..1746111) 1 NC_007880.1 hypothetical protein 1746111 3951876 FTL_1811 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514436.1 1745659 R 376619 CDS YP_514437.1 89257075 3951877 complement(1746337..1747371) 1 NC_007880.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 1747371 hemE 3951877 hemE Francisella tularensis subsp. holarctica LVS uroporphyrinogen decarboxylase YP_514437.1 1746337 R 376619 CDS YP_514438.1 89257076 3952131 complement(join(1748863..1749417,1749417..1749743)) 1 NC_007880.1 transposase 1749743 isftu1 3952131 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514438.1 1748863 R 376619 CDS YP_514439.1 89257077 3952427 complement(1750154..1751605) 1 NC_007880.1 NADH dehydrogenase I subunit N 1751605 3952427 FTL_1817 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase I subunit N YP_514439.1 1750154 R 376619 CDS YP_514440.1 89257078 3952428 complement(1751621..1753210) 1 NC_007880.1 NADH dehydrogenase I subunit M 1753210 3952428 FTL_1818 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase I subunit M YP_514440.1 1751621 R 376619 CDS YP_514441.1 89257079 3952429 complement(1753236..1755245) 1 NC_007880.1 NADH dehydrogenase I subunit L 1755245 3952429 FTL_1819 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase I subunit L YP_514441.1 1753236 R 376619 CDS YP_514442.1 89257080 3952430 complement(1755255..1755572) 1 NC_007880.1 NADH dehydrogenase I subunit K 1755572 3952430 FTL_1820 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase I subunit K YP_514442.1 1755255 R 376619 CDS YP_514443.1 89257081 3952431 complement(1755565..1756170) 1 NC_007880.1 NADH dehydrogenase I subunit J 1756170 3952431 FTL_1821 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase I subunit J YP_514443.1 1755565 R 376619 CDS YP_514444.1 89257082 3952432 complement(1756175..1756663) 1 NC_007880.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 1756663 3952432 FTL_1822 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase subunit I YP_514444.1 1756175 R 376619 CDS YP_514445.1 89257083 3952433 complement(1756677..1757687) 1 NC_007880.1 NADH dehydrogenase I subunit H 1757687 3952433 FTL_1823 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase I subunit H YP_514445.1 1756677 R 376619 CDS YP_514446.1 89257084 3952434 complement(1757689..1760055) 1 NC_007880.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit G 1760055 3952434 FTL_1824 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase subunit G YP_514446.1 1757689 R 376619 CDS YP_514447.1 89257085 3952435 complement(1760073..1761347) 1 NC_007880.1 NADH dehydrogenase I subunit F 1761347 3952435 FTL_1825 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase I subunit F YP_514447.1 1760073 R 376619 CDS YP_514448.1 89257086 3952436 complement(1761354..1761842) 1 NC_007880.1 NADH dehydrogenase I subunit E 1761842 3952436 FTL_1826 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase I subunit E YP_514448.1 1761354 R 376619 CDS YP_514449.1 89257087 3952437 complement(1761852..1763105) 1 NC_007880.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 1763105 3952437 FTL_1827 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase subunit D YP_514449.1 1761852 R 376619 CDS YP_514450.1 89257088 3952438 complement(1763127..1763771) 1 NC_007880.1 NADH dehydrogenase I 1763771 3952438 FTL_1828 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase I YP_514450.1 1763127 R 376619 CDS YP_514451.1 89257089 3952439 complement(1763774..1764250) 1 NC_007880.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 1764250 3952439 FTL_1829 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase subunit B YP_514451.1 1763774 R 376619 CDS YP_514452.1 89257090 3952440 complement(1764241..1764639) 1 NC_007880.1 NADH dehydrogenase I subunit A 1764639 3952440 FTL_1830 Francisella tularensis subsp. holarctica LVS NADH dehydrogenase I subunit A YP_514452.1 1764241 R 376619 CDS YP_514453.1 89257091 3952441 1764848..1765270 1 NC_007880.1 ferric uptake regulation protein 1765270 3952441 FTL_1831 Francisella tularensis subsp. holarctica LVS ferric uptake regulation protein YP_514453.1 1764848 D 376619 CDS YP_514454.1 89257092 3952442 1765524..1767443 1 NC_007880.1 hypothetical protein 1767443 3952442 FTL_1832 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514454.1 1765524 D 376619 CDS YP_514455.1 89257093 3952799 1767450..1768712 1 NC_007880.1 hypothetical protein 1768712 3952799 FTL_1833 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514455.1 1767450 D 376619 CDS YP_514456.1 89257094 3952800 1768705..1769958 1 NC_007880.1 diaminopimelate decarboxylase 1769958 3952800 FTL_1834 Francisella tularensis subsp. holarctica LVS diaminopimelate decarboxylase YP_514456.1 1768705 D 376619 CDS YP_514457.1 89257095 3952801 1769974..1771164 1 NC_007880.1 hypothetical protein 1771164 3952801 FTL_1835 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514457.1 1769974 D 376619 CDS YP_514458.1 89257096 3952802 1771250..1772779 1 NC_007880.1 hypothetical protein 1772779 3952802 FTL_1836 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514458.1 1771250 D 376619 CDS YP_514459.1 89257097 3952803 1772827..1773189 1 NC_007880.1 hypothetical protein 1773189 3952803 FTL_1837 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514459.1 1772827 D 376619 CDS YP_514460.1 89257098 3952804 1773438..1773740 1 NC_007880.1 hypothetical protein 1773740 3952804 FTL_1838 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514460.1 1773438 D 376619 CDS YP_514461.1 89257099 3952805 1773767..1774318 1 NC_007880.1 lipase/acyltransferase 1774318 3952805 FTL_1839 Francisella tularensis subsp. holarctica LVS lipase/acyltransferase YP_514461.1 1773767 D 376619 CDS YP_514462.1 89257100 3952806 complement(1774334..1774741) 1 NC_007880.1 hypothetical protein 1774741 3952806 FTL_1840 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514462.1 1774334 R 376619 CDS YP_514463.1 89257101 3952807 complement(1774756..1776165) 1 NC_007880.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 1776165 gatB 3952807 gatB Francisella tularensis subsp. holarctica LVS aspartyl/glutamyl-tRNA amidotransferase subunit B YP_514463.1 1774756 R 376619 CDS YP_514464.1 89257102 3952808 complement(1776180..1777625) 1 NC_007880.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 1777625 gatA 3952808 gatA Francisella tularensis subsp. holarctica LVS aspartyl/glutamyl-tRNA amidotransferase subunit A YP_514464.1 1776180 R 376619 CDS YP_514465.1 89257103 3952809 complement(1777634..1777915) 1 NC_007880.1 Glu-tRNAGln amidotransferase C subunit 1777915 3952809 FTL_1843 Francisella tularensis subsp. holarctica LVS Glu-tRNAGln amidotransferase C subunit YP_514465.1 1777634 R 376619 CDS YP_514466.1 89257104 3952810 complement(1777998..1778486) 1 NC_007880.1 secretion protein 1778486 3952810 FTL_1844 Francisella tularensis subsp. holarctica LVS secretion protein YP_514466.1 1777998 R 376619 CDS YP_514467.1 89257105 3952811 complement(1778553..1779068) 1 NC_007880.1 RND efflux membrane fusion protein 1779068 3952811 FTL_1845 Francisella tularensis subsp. holarctica LVS RND efflux membrane fusion protein YP_514467.1 1778553 R 376619 CDS YP_514468.1 89257106 3952812 complement(1779193..1779723) 1 NC_007880.1 hypothetical protein 1779723 3952812 FTL_1846 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514468.1 1779193 R 376619 CDS YP_514469.1 89257107 3952813 complement(1779823..1780290) 1 NC_007880.1 toxin secretion ABC transporter ATP-binding protein 1780290 3952813 FTL_1847 Francisella tularensis subsp. holarctica LVS toxin secretion ABC transporter ATP-binding protein YP_514469.1 1779823 R 376619 CDS YP_514470.1 89257108 3952814 complement(1780211..1780615) 1 NC_007880.1 hypothetical protein 1780615 3952814 FTL_1848 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514470.1 1780211 R 376619 CDS YP_514471.1 89257109 3952815 complement(1780702..1781280) 1 NC_007880.1 hypothetical protein 1781280 3952815 FTL_1849 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514471.1 1780702 R 376619 CDS YP_514472.1 89257110 3952816 complement(1781314..1782612) 1 NC_007880.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1782612 3952816 FTL_1850 Francisella tularensis subsp. holarctica LVS adenylosuccinate lyase YP_514472.1 1781314 R 376619 CDS YP_514473.1 89257111 3952367 complement(1782785..1783414) 1 NC_007880.1 transposase 1783414 isftu2 3952367 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_514473.1 1782785 R 376619 CDS YP_514474.1 89257112 3952817 1783795..1784193 1 NC_007880.1 hypothetical protein 1784193 3952817 FTL_1852 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514474.1 1783795 D 376619 CDS YP_514475.1 89257113 3952818 1784436..1785218 1 NC_007880.1 lipoprotein 1785218 3952818 FTL_1853 Francisella tularensis subsp. holarctica LVS lipoprotein YP_514475.1 1784436 D 376619 CDS YP_514476.1 89257114 3950901 complement(1785236..1786096) 1 NC_007880.1 hypothetical protein 1786096 3950901 FTL_1854 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514476.1 1785236 R 376619 CDS YP_514477.1 89257115 3950907 complement(1788213..1792085) 1 NC_007880.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 1792085 3950907 FTL_1860 Francisella tularensis subsp. holarctica LVS phosphoribosylformylglycinamidine synthase YP_514477.1 1788213 R 376619 CDS YP_514478.1 89257116 3950908 complement(1792085..1793575) 1 NC_007880.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 1793575 3950908 FTL_1861 Francisella tularensis subsp. holarctica LVS amidophosphoribosyltransferase YP_514478.1 1792085 R 376619 CDS YP_514479.1 89257117 3950909 complement(1793669..1793878) 1 NC_007880.1 hypothetical protein 1793878 3950909 FTL_1862 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514479.1 1793669 R 376619 CDS YP_514480.1 89257118 3950910 complement(1793853..1794974) 1 NC_007880.1 glutamate decarboxylase 1794974 3950910 FTL_1863 Francisella tularensis subsp. holarctica LVS glutamate decarboxylase YP_514480.1 1793853 R 376619 CDS YP_514481.1 89257119 3950911 complement(1794985..1795626) 1 NC_007880.1 hypothetical protein 1795626 3950911 FTL_1864 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514481.1 1794985 R 376619 CDS YP_514482.1 89257120 3950912 complement(1795635..1797164) 1 NC_007880.1 outer membrane protein tolC 1797164 3950912 FTL_1865 Francisella tularensis subsp. holarctica LVS outer membrane protein tolC YP_514482.1 1795635 R 376619 CDS YP_514483.1 89257121 3950913 complement(1797173..1797793) 1 NC_007880.1 protein-L-isoaspartate O-methyltransferase 1797793 3950913 FTL_1866 Francisella tularensis subsp. holarctica LVS protein-L-isoaspartate O-methyltransferase YP_514483.1 1797173 R 376619 CDS YP_514484.1 89257122 3950914 1798113..1799444 1 NC_007880.1 protease yegQ 1799444 3950914 FTL_1867 Francisella tularensis subsp. holarctica LVS protease yegQ YP_514484.1 1798113 D 376619 CDS YP_514485.1 89257123 3950915 complement(1799484..1800665) 1 NC_007880.1 multidrug resistance protein, membrane located 1800665 3950915 FTL_1868 Francisella tularensis subsp. holarctica LVS multidrug resistance protein, membrane located YP_514485.1 1799484 R 376619 CDS YP_514486.1 89257124 3950916 1800840..1802267 1 NC_007880.1 Na+/H+ antiporter 1802267 3950916 FTL_1869 Francisella tularensis subsp. holarctica LVS Na+/H+ antiporter YP_514486.1 1800840 D 376619 CDS YP_514487.1 89257125 3952189 complement(1803907..1805781) 1 NC_007880.1 amino acid transporter 1805781 3952189 FTL_1873 Francisella tularensis subsp. holarctica LVS amino acid transporter YP_514487.1 1803907 R 376619 CDS YP_514488.1 89257126 3952190 complement(1805788..1806792) 1 NC_007880.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1806792 obgE 3952190 obgE Francisella tularensis subsp. holarctica LVS GTPase ObgE YP_514488.1 1805788 R 376619 CDS YP_514489.1 89257127 3952191 complement(1806868..1808064) 1 NC_007880.1 aromatic amino acid HAAP transporter 1808064 3952191 FTL_1875 Francisella tularensis subsp. holarctica LVS aromatic amino acid HAAP transporter YP_514489.1 1806868 R 376619 CDS YP_514490.1 89257128 3952192 complement(1808659..1809114) 1 NC_007880.1 outer membrane associated protein, fragment 1809114 3952192 FTL_1876 Francisella tularensis subsp. holarctica LVS outer membrane associated protein, fragment YP_514490.1 1808659 R 376619 CDS YP_514491.1 89257129 3952194 complement(1810079..1811656) 1 NC_007880.1 two component sensor protein kdpD 1811656 3952194 FTL_1878 Francisella tularensis subsp. holarctica LVS two component sensor protein kdpD YP_514491.1 1810079 R 376619 CDS YP_514492.1 89257130 3952195 complement(1811748..1812761) 1 NC_007880.1 osmosensitive K+ channel His kinase sensor 1812761 3952195 FTL_1879 Francisella tularensis subsp. holarctica LVS osmosensitive K+ channel His kinase sensor YP_514492.1 1811748 R 376619 CDS YP_514493.1 89257131 3952196 complement(1812865..1813419) 1 NC_007880.1 potassium-transporting ATPase C chain 1813419 3952196 FTL_1880 Francisella tularensis subsp. holarctica LVS potassium-transporting ATPase C chain YP_514493.1 1812865 R 376619 CDS YP_514494.1 89257132 3952197 complement(1813436..1814341) 1 NC_007880.1 haloacid dehalogenase-like hydrolase 1814341 3952197 FTL_1881 Francisella tularensis subsp. holarctica LVS haloacid dehalogenase-like hydrolase YP_514494.1 1813436 R 376619 CDS YP_514495.1 89257133 3952198 complement(1814370..1815413) 1 NC_007880.1 potassium-transporting ATPase B chain 1815413 3952198 FTL_1882 Francisella tularensis subsp. holarctica LVS potassium-transporting ATPase B chain YP_514495.1 1814370 R 376619 CDS YP_514496.1 89257134 3952199 complement(1815423..1817144) 1 NC_007880.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 1817144 3952199 FTL_1883 Francisella tularensis subsp. holarctica LVS potassium-transporting ATPase subunit A YP_514496.1 1815423 R 376619 CDS YP_514497.1 89257135 3952200 complement(1817451..1817687) 1 NC_007880.1 hypothetical protein 1817687 3952200 FTL_1884 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514497.1 1817451 R 376619 CDS YP_514498.1 89257136 3952368 complement(1817620..1818408) 1 NC_007880.1 transposase 1818408 isftu2 3952368 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_514498.1 1817620 R 376619 CDS YP_514499.1 89257137 3951799 complement(join(1818626..1819129,1819129..1819455)) 1 NC_007880.1 transposase 1819455 isftu1 3951799 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514499.1 1818626 R 376619 CDS YP_514500.1 89257138 3952201 complement(1819695..1820105) 1 NC_007880.1 3-isopropylmalate dehydrogenase 1820105 3952201 FTL_1887 Francisella tularensis subsp. holarctica LVS 3-isopropylmalate dehydrogenase YP_514500.1 1819695 R 376619 CDS YP_514501.1 89257139 3952202 complement(1820693..1821262) 1 NC_007880.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 1821262 leuD 3952202 leuD Francisella tularensis subsp. holarctica LVS isopropylmalate isomerase small subunit YP_514501.1 1820693 R 376619 CDS YP_514502.1 89257140 3952203 complement(1821265..1822668) 1 NC_007880.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 1822668 3952203 FTL_1889 Francisella tularensis subsp. holarctica LVS isopropylmalate isomerase large subunit YP_514502.1 1821265 R 376619 CDS YP_514503.1 89257141 3951800 join(1822946..1823272,1823272..1823826) 1 NC_007880.1 transposase 1823826 isftu1 3951800 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514503.1 1822946 D 376619 CDS YP_514504.1 89257142 3952205 complement(1824022..1825017) 1 NC_007880.1 hypothetical protein 1825017 3952205 FTL_1892 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514504.1 1824022 R 376619 CDS YP_514505.1 89257143 3952206 1825374..1825910 1 NC_007880.1 transposase 1825910 3952206 FTL_1894 Francisella tularensis subsp. holarctica LVS transposase YP_514505.1 1825374 D 376619 CDS YP_514506.1 89257144 3952208 complement(1826422..1827819) 1 NC_007880.1 hypothetical protein 1827819 3952208 FTL_1896 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514506.1 1826422 R 376619 CDS YP_514507.1 89257145 3952132 complement(1827983..1828501) 1 NC_007880.1 outer membrane lipoprotein 1828501 3952132 FTL_1897 Francisella tularensis subsp. holarctica LVS outer membrane lipoprotein YP_514507.1 1827983 R 376619 CDS YP_514508.1 89257146 3952133 1828587..1829564 1 NC_007880.1 DNA polymerase III subunit delta 1829564 3952133 FTL_1898 Francisella tularensis subsp. holarctica LVS DNA polymerase III subunit delta YP_514508.1 1828587 D 376619 CDS YP_514509.1 89257147 3952134 1829684..1830721 1 NC_007880.1 glutamine synthetase 1830721 3952134 FTL_1899 Francisella tularensis subsp. holarctica LVS glutamine synthetase YP_514509.1 1829684 D 376619 CDS YP_514510.1 89257148 3952135 1830803..1832344 1 NC_007880.1 L-glutaminase 1832344 3952135 FTL_1900 Francisella tularensis subsp. holarctica LVS L-glutaminase YP_514510.1 1830803 D 376619 CDS YP_514511.1 89257149 3952136 1832353..1833138 1 NC_007880.1 hypothetical protein 1833138 3952136 FTL_1901 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514511.1 1832353 D 376619 CDS YP_514512.1 89257150 3952137 1833326..1833868 1 NC_007880.1 hypothetical protein 1833868 3952137 FTL_1902 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514512.1 1833326 D 376619 CDS YP_514513.1 89257151 3952138 complement(1834253..1835935) 1 NC_007880.1 lysyl-tRNA synthetase 1835935 3952138 FTL_1903 Francisella tularensis subsp. holarctica LVS lysyl-tRNA synthetase YP_514513.1 1834253 R 376619 CDS YP_514514.1 89257152 3952139 complement(1836113..1837090) 1 NC_007880.1 peptide chain release factor 2 1837090 3952139 FTL_1904 Francisella tularensis subsp. holarctica LVS peptide chain release factor 2 YP_514514.1 1836113 R 376619 CDS YP_514515.1 89257153 3952140 1837363..1839000 1 NC_007880.1 DNA polymerase III subunit gamma and tau 1839000 3952140 FTL_1905 Francisella tularensis subsp. holarctica LVS DNA polymerase III subunit gamma and tau YP_514515.1 1837363 D 376619 CDS YP_514516.1 89257154 3952141 complement(1839014..1839874) 1 NC_007880.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 1839874 lpxC 3952141 lpxC Francisella tularensis subsp. holarctica LVS UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_514516.1 1839014 R 376619 CDS YP_514517.1 89257155 3952142 complement(1839897..1841042) 1 NC_007880.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1841042 3952142 FTL_1907 Francisella tularensis subsp. holarctica LVS cell division protein FtsZ YP_514517.1 1839897 R 376619 CDS YP_514518.1 89257156 3952143 complement(1841086..1842348) 1 NC_007880.1 cell division protein FtsA 1842348 3952143 FTL_1908 Francisella tularensis subsp. holarctica LVS cell division protein FtsA YP_514518.1 1841086 R 376619 CDS YP_514519.1 89257157 3952144 complement(1842450..1843133) 1 NC_007880.1 cell division protein FtsQ 1843133 3952144 FTL_1909 Francisella tularensis subsp. holarctica LVS cell division protein FtsQ YP_514519.1 1842450 R 376619 CDS YP_514520.1 89257158 3952145 complement(1843130..1844020) 1 NC_007880.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 1844020 3952145 FTL_1910 Francisella tularensis subsp. holarctica LVS D-alanyl-alanine synthetase A YP_514520.1 1843130 R 376619 CDS YP_514521.1 89257159 3952146 complement(1844024..1844485) 1 NC_007880.1 zinc-binding domain-containing protein 1844485 3952146 FTL_1911 Francisella tularensis subsp. holarctica LVS zinc-binding domain-containing protein YP_514521.1 1844024 R 376619 CDS YP_514522.1 89257160 3952147 1844633..1846303 1 NC_007880.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1846303 rpsA 3952147 rpsA Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S1 YP_514522.1 1844633 D 376619 CDS YP_514523.1 89257161 3952148 1846420..1846962 1 NC_007880.1 Sua5/YciO/YrdC family protein 1846962 3952148 FTL_1913 Francisella tularensis subsp. holarctica LVS Sua5/YciO/YrdC family protein YP_514523.1 1846420 D 376619 CDS YP_514524.1 89257162 3952149 1847060..1847596 1 NC_007880.1 hypothetical protein 1847596 3952149 FTL_1914 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514524.1 1847060 D 376619 CDS YP_514525.1 89257163 3952150 complement(1847982..1848872) 1 NC_007880.1 putative acyltransferase 1848872 3952150 FTL_1915 Francisella tularensis subsp. holarctica LVS putative acyltransferase YP_514525.1 1847982 R 376619 CDS YP_514526.1 89257164 3951976 complement(1848973..1850988) 1 NC_007880.1 competence-like protein 1850988 3951976 FTL_1916 Francisella tularensis subsp. holarctica LVS competence-like protein YP_514526.1 1848973 R 376619 CDS YP_514527.1 89257165 3951977 1851152..1851973 1 NC_007880.1 30S ribosomal protein S6 1851973 3951977 FTL_1917 Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S6 YP_514527.1 1851152 D 376619 CDS YP_514528.1 89257166 3951978 1851946..1852308 1 NC_007880.1 30S ribosomal protein S6 modification protein-like protein 1852308 3951978 FTL_1918 Francisella tularensis subsp. holarctica LVS 30S ribosomal protein S6 modification protein-like protein YP_514528.1 1851946 D 376619 CDS YP_514529.1 89257167 3951981 1854557..1855339 1 NC_007880.1 ABC transporter ATP-binding protein 1855339 3951981 FTL_1921 Francisella tularensis subsp. holarctica LVS ABC transporter ATP-binding protein YP_514529.1 1854557 D 376619 CDS YP_514530.1 89257168 3951982 complement(1855333..1855902) 1 NC_007880.1 YggT family protein 1855902 3951982 FTL_1922 Francisella tularensis subsp. holarctica LVS YggT family protein YP_514530.1 1855333 R 376619 CDS YP_514531.1 89257169 3951983 complement(1856017..1856832) 1 NC_007880.1 hypothetical protein 1856832 3951983 FTL_1923 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514531.1 1856017 R 376619 CDS YP_514532.1 89257170 3951801 complement(join(1857257..1857811,1857811..1858137)) 1 NC_007880.1 transposase 1858137 isftu1 3951801 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514532.1 1857257 R 376619 CDS YP_514533.1 89257171 3952370 complement(1858199..1858657) 1 NC_007880.1 transposase 1858657 isftu2 3952370 isftu2 Francisella tularensis subsp. holarctica LVS transposase YP_514533.1 1858199 R 376619 CDS YP_514534.1 89257172 3951987 complement(1860055..1861602) 1 NC_007880.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1861602 purH 3951987 purH Francisella tularensis subsp. holarctica LVS bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_514534.1 1860055 R 376619 CDS YP_514535.1 89257173 3951988 1861779..1863065 1 NC_007880.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 1863065 3951988 FTL_1930 Francisella tularensis subsp. holarctica LVS adenylosuccinate synthetase YP_514535.1 1861779 D 376619 CDS YP_514536.1 89257174 3951989 1863069..1863602 1 NC_007880.1 hypoxanthine-guanine phosphoribosyltransferase 1863602 3951989 FTL_1931 Francisella tularensis subsp. holarctica LVS hypoxanthine-guanine phosphoribosyltransferase YP_514536.1 1863069 D 376619 CDS YP_514537.1 89257175 3951992 complement(1864432..1865295) 1 NC_007880.1 ABC transporter permease 1865295 3951992 FTL_1934 Francisella tularensis subsp. holarctica LVS ABC transporter permease YP_514537.1 1864432 R 376619 CDS YP_514538.1 89257176 3951993 complement(1865216..1865893) 1 NC_007880.1 ABC transporter ATP-binding protein 1865893 3951993 FTL_1935 Francisella tularensis subsp. holarctica LVS ABC transporter ATP-binding protein YP_514538.1 1865216 R 376619 CDS YP_514539.1 89257177 3951994 complement(1865895..1866812) 1 NC_007880.1 periplasmic solute binding family protein 1866812 3951994 FTL_1936 Francisella tularensis subsp. holarctica LVS periplasmic solute binding family protein YP_514539.1 1865895 R 376619 CDS YP_514540.1 89257178 3952579 complement(1868224..1868688) 1 NC_007880.1 outer membrane lipoprotein 1868688 3952579 FTL_1939 Francisella tularensis subsp. holarctica LVS outer membrane lipoprotein YP_514540.1 1868224 R 376619 CDS YP_514541.1 89257179 3952580 complement(1868699..1869295) 1 NC_007880.1 trp repressor binding protein 1869295 3952580 FTL_1940 Francisella tularensis subsp. holarctica LVS trp repressor binding protein YP_514541.1 1868699 R 376619 CDS YP_514542.1 89257180 3952581 1869302..1870489 1 NC_007880.1 tRNA processing ribonuclease BN 1870489 3952581 FTL_1941 Francisella tularensis subsp. holarctica LVS tRNA processing ribonuclease BN YP_514542.1 1869302 D 376619 CDS YP_514543.1 89257181 3952582 1870508..1871083 1 NC_007880.1 transporter 1871083 3952582 FTL_1942 Francisella tularensis subsp. holarctica LVS transporter YP_514543.1 1870508 D 376619 CDS YP_514544.1 89257182 3952583 1871080..1873233 1 NC_007880.1 primosomal protein N' 1873233 3952583 FTL_1943 Francisella tularensis subsp. holarctica LVS primosomal protein N' YP_514544.1 1871080 D 376619 CDS YP_514545.1 89257183 3951802 join(1873363..1873689,1873689..1874243) 1 NC_007880.1 transposase 1874243 isftu1 3951802 isftu1 Francisella tularensis subsp. holarctica LVS transposase YP_514545.1 1873363 D 376619 CDS YP_514546.1 89257184 3952584 complement(1874376..1874636) 1 NC_007880.1 hypothetical protein 1874636 3952584 FTL_1945 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514546.1 1874376 R 376619 CDS YP_514547.1 89257185 3952585 complement(1874771..1875124) 1 NC_007880.1 hypothetical protein 1875124 3952585 FTL_1946 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514547.1 1874771 R 376619 CDS YP_514548.1 89257186 3952586 complement(1875078..1876757) 1 NC_007880.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 1876757 3952586 FTL_1947 Francisella tularensis subsp. holarctica LVS putative ABC transporter ATP-binding protein YP_514548.1 1875078 R 376619 CDS YP_514549.1 89257187 3952587 1876925..1878211 1 NC_007880.1 major facilitator transporter 1878211 3952587 FTL_1948 Francisella tularensis subsp. holarctica LVS major facilitator transporter YP_514549.1 1876925 D 376619 CDS YP_514550.1 89257188 3952588 complement(1878510..1878722) 1 NC_007880.1 hypothetical protein 1878722 3952588 FTL_1949 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514550.1 1878510 R 376619 CDS YP_514551.1 89257189 3952589 1878768..1879748 1 NC_007880.1 hypothetical protein 1879748 3952589 FTL_1950 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514551.1 1878768 D 376619 CDS YP_514552.1 89257190 3952590 complement(1879755..1880030) 1 NC_007880.1 amino acid transporter LysE 1880030 3952590 FTL_1951 Francisella tularensis subsp. holarctica LVS amino acid transporter LysE YP_514552.1 1879755 R 376619 CDS YP_514553.1 89257191 3952593 1882141..1882467 1 NC_007880.1 hypothetical protein 1882467 3952593 FTL_1954 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514553.1 1882141 D 376619 CDS YP_514554.1 89257192 3952595 complement(1883263..1885839) 1 NC_007880.1 aminopeptidase N 1885839 pepN 3952595 pepN Francisella tularensis subsp. holarctica LVS aminopeptidase N YP_514554.1 1883263 R 376619 CDS YP_514555.1 89257193 3952596 1886041..1886469 1 NC_007880.1 heat shock protein 1886469 3952596 FTL_1957 Francisella tularensis subsp. holarctica LVS heat shock protein YP_514555.1 1886041 D 376619 CDS YP_514556.1 89257194 3952034 complement(1886466..1887827) 1 NC_007880.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1887827 3952034 FTL_1958 Francisella tularensis subsp. holarctica LVS bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_514556.1 1886466 R 376619 CDS YP_514557.1 89257195 3952035 complement(1887919..1888098) 1 NC_007880.1 hypothetical protein 1888098 3952035 FTL_1959 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514557.1 1887919 R 376619 CDS YP_514558.1 89257196 3952036 complement(1888335..1889024) 1 NC_007880.1 peptide methionine sulfoxide reductase MsrA 1889024 3952036 FTL_1960 Francisella tularensis subsp. holarctica LVS peptide methionine sulfoxide reductase MsrA YP_514558.1 1888335 R 376619 CDS YP_514559.1 89257197 3952037 complement(1889108..1889476) 1 NC_007880.1 hypothetical protein 1889476 3952037 FTL_1961 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514559.1 1889108 R 376619 CDS YP_514560.1 89257198 3952038 complement(1889469..1889810) 1 NC_007880.1 hypothetical protein 1889810 3952038 FTL_1962 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514560.1 1889469 R 376619 CDS YP_514561.1 89257199 3952039 complement(1889879..1890280) 1 NC_007880.1 hypothetical protein 1890280 3952039 FTL_1963 Francisella tularensis subsp. holarctica LVS hypothetical protein YP_514561.1 1889879 R 376619 CDS YP_514562.1 89257200 3952042 complement(1891973..1893517) 1 NC_007880.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1893517 3952042 FTL_1966 Francisella tularensis subsp. holarctica LVS anthranilate synthase component I YP_514562.1 1891973 R 376619 CDS YP_514563.1 89257201 3952043 complement(1893526..1893813) 1 NC_007880.1 trp operon repressor 1893813 3952043 FTL_1967 Francisella tularensis subsp. holarctica LVS trp operon repressor YP_514563.1 1893526 R 376619 CDS YP_514564.1 89257202 3952044 complement(1894287..1895783) 1 NC_007880.1 ribonuclease G 1895783 3952044 FTL_1968 Francisella tularensis subsp. holarctica LVS ribonuclease G YP_514564.1 1894287 R 376619 CDS