-- dump date 20140619_095324 -- class Genbank::misc_feature -- table misc_feature_note -- id note 376619000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 376619000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 376619000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 376619000004 Walker A motif; other site 376619000005 ATP binding site [chemical binding]; other site 376619000006 Walker B motif; other site 376619000007 arginine finger; other site 376619000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 376619000009 DnaA box-binding interface [nucleotide binding]; other site 376619000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 376619000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 376619000012 putative DNA binding surface [nucleotide binding]; other site 376619000013 dimer interface [polypeptide binding]; other site 376619000014 beta-clamp/clamp loader binding surface; other site 376619000015 beta-clamp/translesion DNA polymerase binding surface; other site 376619000016 metabolite-proton symporter; Region: 2A0106; TIGR00883 376619000017 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000018 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000019 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000021 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 376619000022 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 376619000023 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 376619000024 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 376619000025 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 376619000026 TPP-binding site [chemical binding]; other site 376619000027 dimer interface [polypeptide binding]; other site 376619000028 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 376619000029 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 376619000030 tandem repeat interface [polypeptide binding]; other site 376619000031 oligomer interface [polypeptide binding]; other site 376619000032 active site residues [active] 376619000033 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 376619000034 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 376619000035 preprotein translocase subunit SecB; Provisional; Region: PRK13031 376619000036 SecA binding site; other site 376619000037 Preprotein binding site; other site 376619000038 recombinase A; Provisional; Region: recA; PRK09354 376619000039 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 376619000040 hexamer interface [polypeptide binding]; other site 376619000041 Walker A motif; other site 376619000042 ATP binding site [chemical binding]; other site 376619000043 Walker B motif; other site 376619000044 recombination regulator RecX; Reviewed; Region: recX; PRK00117 376619000045 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 376619000046 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 376619000047 dimer interface [polypeptide binding]; other site 376619000048 ssDNA binding site [nucleotide binding]; other site 376619000049 tetramer (dimer of dimers) interface [polypeptide binding]; other site 376619000050 propionate/acetate kinase; Provisional; Region: PRK12379 376619000051 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 376619000052 phosphate acetyltransferase; Reviewed; Region: PRK05632 376619000053 DRTGG domain; Region: DRTGG; pfam07085 376619000054 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 376619000055 Succinate-semialdehyde dehydrogenase,pseudogene 376619000056 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000057 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000058 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000060 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 376619000061 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 376619000062 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 376619000063 dimer interface [polypeptide binding]; other site 376619000064 anticodon binding site; other site 376619000065 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 376619000066 homodimer interface [polypeptide binding]; other site 376619000067 motif 1; other site 376619000068 active site 376619000069 motif 2; other site 376619000070 GAD domain; Region: GAD; pfam02938 376619000071 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 376619000072 active site 376619000073 motif 3; other site 376619000074 metabolite-proton symporter; Region: 2A0106; TIGR00883 376619000075 Succinate-semialdehyde dehydrogenase, fragment 376619000076 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000077 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000078 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000080 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 376619000081 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 376619000082 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 376619000083 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 376619000084 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 376619000085 NAD binding site [chemical binding]; other site 376619000086 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 376619000087 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 376619000088 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 376619000089 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 376619000090 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 376619000091 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 376619000092 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 376619000093 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 376619000094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 376619000095 ATP-grasp domain; Region: ATP-grasp_4; cl17255 376619000096 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 376619000097 substrate binding site [chemical binding]; other site 376619000098 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 376619000099 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 376619000100 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 376619000101 catalytic site [active] 376619000102 subunit interface [polypeptide binding]; other site 376619000103 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 376619000104 catalytic core [active] 376619000105 thiopurine S-methyltransferase; Reviewed; Region: PRK13256 376619000106 dihydroorotase; Reviewed; Region: PRK09236 376619000107 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 376619000108 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 376619000109 active site 376619000110 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 376619000111 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 376619000112 HlyD family secretion protein; Region: HlyD; pfam00529 376619000113 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 376619000114 HlyD family secretion protein; Region: HlyD_3; pfam13437 376619000115 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 376619000116 Transcriptional regulator [Transcription]; Region: LysR; COG0583 376619000117 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 376619000118 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 376619000119 dimerization interface [polypeptide binding]; other site 376619000120 SOUL heme-binding protein; Region: SOUL; pfam04832 376619000121 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619000122 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619000123 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619000124 Chorismate mutase type II; Region: CM_2; smart00830 376619000125 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 376619000126 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 376619000127 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 376619000128 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 376619000129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 376619000130 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 376619000131 active site 376619000132 dimer interface [polypeptide binding]; other site 376619000133 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 376619000134 phosphate binding site [ion binding]; other site 376619000135 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 376619000136 prephenate dehydrogenase; Provisional; Region: PRK06444 376619000137 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 376619000138 putative active site [active] 376619000139 dimerization interface [polypeptide binding]; other site 376619000140 putative tRNAtyr binding site [nucleotide binding]; other site 376619000141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619000142 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 376619000143 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 376619000144 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 376619000145 substrate binding [chemical binding]; other site 376619000146 active site 376619000147 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000148 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000149 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000151 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 376619000152 putative FMN binding site [chemical binding]; other site 376619000153 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 376619000154 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 376619000155 aromatic amino acid transport protein; Region: araaP; TIGR00837 376619000156 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 376619000157 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 376619000158 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 376619000159 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 376619000160 catalytic residue [active] 376619000161 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 376619000162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 376619000163 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 376619000164 putative effector binding pocket; other site 376619000165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619000166 putative substrate translocation pore; other site 376619000167 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 376619000168 conserved hypothetical protein predicted by GeneMark 376619000169 conserved hypothetical protein, pseudogene 376619000170 conserved hypothetical protein predicted by GeneMark 376619000171 hypothetical protein 376619000172 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 376619000173 dimer interface [polypeptide binding]; other site 376619000174 active site 376619000175 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 376619000176 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 376619000177 GTP-binding protein LepA; Provisional; Region: PRK05433 376619000178 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 376619000179 G1 box; other site 376619000180 putative GEF interaction site [polypeptide binding]; other site 376619000181 GTP/Mg2+ binding site [chemical binding]; other site 376619000182 Switch I region; other site 376619000183 G2 box; other site 376619000184 G3 box; other site 376619000185 Switch II region; other site 376619000186 G4 box; other site 376619000187 G5 box; other site 376619000188 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 376619000189 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 376619000190 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 376619000191 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 376619000192 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 376619000193 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 376619000194 active site 376619000195 catalytic residues [active] 376619000196 metal binding site [ion binding]; metal-binding site 376619000197 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 376619000198 homopentamer interface [polypeptide binding]; other site 376619000199 active site 376619000200 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 376619000201 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 376619000202 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 376619000203 dimerization interface [polypeptide binding]; other site 376619000204 active site 376619000205 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 376619000206 Lumazine binding domain; Region: Lum_binding; pfam00677 376619000207 Lumazine binding domain; Region: Lum_binding; pfam00677 376619000208 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 376619000209 catalytic motif [active] 376619000210 Zn binding site [ion binding]; other site 376619000211 RibD C-terminal domain; Region: RibD_C; cl17279 376619000212 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619000213 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619000214 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619000215 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000216 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000218 major facilitator superfamily (MFS) transport protein, pseudogene 376619000219 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 376619000220 oxidase-related protein 376619000221 Oxidase-like protein, pseudogene 376619000222 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854 376619000223 hypothetical protein; Provisional; Region: PRK05421 376619000224 putative catalytic site [active] 376619000225 putative metal binding site [ion binding]; other site 376619000226 putative phosphate binding site [ion binding]; other site 376619000227 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 376619000228 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 376619000229 putative acyl-acceptor binding pocket; other site 376619000230 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 376619000231 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 376619000232 putative acyl-acceptor binding pocket; other site 376619000233 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 376619000234 4Fe-4S binding domain; Region: Fer4; cl02805 376619000235 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 376619000236 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 376619000237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 376619000238 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 376619000239 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 376619000240 ATP-grasp domain; Region: ATP-grasp; pfam02222 376619000241 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 376619000242 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 376619000243 active site 376619000244 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 376619000245 Clp amino terminal domain; Region: Clp_N; pfam02861 376619000246 Clp amino terminal domain; Region: Clp_N; pfam02861 376619000247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 376619000248 Walker A motif; other site 376619000249 ATP binding site [chemical binding]; other site 376619000250 Walker B motif; other site 376619000251 arginine finger; other site 376619000252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 376619000253 Walker A motif; other site 376619000254 ATP binding site [chemical binding]; other site 376619000255 Walker B motif; other site 376619000256 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 376619000257 hypothetical protein 376619000258 conserved hypothetical membrane protein,pseudogene 376619000259 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 376619000260 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 376619000261 substrate binding site [chemical binding]; other site 376619000262 active site 376619000263 catalytic residues [active] 376619000264 heterodimer interface [polypeptide binding]; other site 376619000265 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 376619000266 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 376619000267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 376619000268 catalytic residue [active] 376619000269 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 376619000270 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 376619000271 active site 376619000272 Zn binding site [ion binding]; other site 376619000273 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 376619000274 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 376619000275 Cl- selectivity filter; other site 376619000276 Cl- binding residues [ion binding]; other site 376619000277 pore gating glutamate residue; other site 376619000278 dimer interface [polypeptide binding]; other site 376619000279 H+/Cl- coupling transport residue; other site 376619000280 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 376619000281 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 376619000282 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 376619000283 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 376619000284 conserved hypothetical membrane, pseudogene 376619000285 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000286 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000287 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000288 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619000290 putative substrate translocation pore; other site 376619000291 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 376619000292 Protein of unknown function (DUF877); Region: DUF877; pfam05943 376619000293 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 376619000294 Intracellular growth locus C protein; Region: IglC; pfam11550 376619000295 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 376619000296 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 376619000297 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 376619000298 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 376619000299 NAD binding site [chemical binding]; other site 376619000300 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000301 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000302 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000304 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 376619000305 active site 376619000306 metal binding site [ion binding]; metal-binding site 376619000307 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 376619000308 catalytic residues [active] 376619000309 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 376619000310 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 376619000311 homodimer interface [polypeptide binding]; other site 376619000312 substrate-cofactor binding pocket; other site 376619000313 catalytic residue [active] 376619000314 pyruvate phosphate dikinase; Provisional; Region: PRK09279 376619000315 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 376619000316 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 376619000317 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 376619000318 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 376619000319 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 376619000320 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 376619000321 G1 box; other site 376619000322 GTP/Mg2+ binding site [chemical binding]; other site 376619000323 Switch I region; other site 376619000324 G2 box; other site 376619000325 G3 box; other site 376619000326 Switch II region; other site 376619000327 G4 box; other site 376619000328 G5 box; other site 376619000329 Nucleoside recognition; Region: Gate; pfam07670 376619000330 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 376619000331 Nucleoside recognition; Region: Gate; pfam07670 376619000332 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000333 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000334 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000336 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 376619000337 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 376619000338 RNB domain; Region: RNB; pfam00773 376619000339 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 376619000340 putative hydrolase; Provisional; Region: PRK11460 376619000341 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 376619000342 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 376619000343 domain interfaces; other site 376619000344 active site 376619000345 camphor resistance protein CrcB; Provisional; Region: PRK14226 376619000346 Zinc-finger domain; Region: zf-CHCC; cl01821 376619000347 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 376619000348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 376619000349 dimer interface [polypeptide binding]; other site 376619000350 conserved gate region; other site 376619000351 putative PBP binding loops; other site 376619000352 ABC-ATPase subunit interface; other site 376619000353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 376619000354 dimer interface [polypeptide binding]; other site 376619000355 conserved gate region; other site 376619000356 putative PBP binding loops; other site 376619000357 ABC-ATPase subunit interface; other site 376619000358 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 376619000359 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 376619000360 Walker A/P-loop; other site 376619000361 ATP binding site [chemical binding]; other site 376619000362 Q-loop/lid; other site 376619000363 ABC transporter signature motif; other site 376619000364 Walker B; other site 376619000365 D-loop; other site 376619000366 H-loop/switch region; other site 376619000367 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 376619000368 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 376619000369 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 376619000370 TrkA-N domain; Region: TrkA_N; pfam02254 376619000371 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 376619000372 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 376619000373 trimer interface [polypeptide binding]; other site 376619000374 putative metal binding site [ion binding]; other site 376619000375 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 376619000376 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 376619000377 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 376619000378 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000379 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000380 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000382 Hypothetical protein, pseudogene 376619000383 cytochrome b561 family protein, pseudogene 376619000384 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 376619000385 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 376619000386 Phosphoesterase family; Region: Phosphoesterase; pfam04185 376619000387 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 376619000388 LamB/YcsF family protein; Provisional; Region: PRK05406 376619000389 conserved hypothetical protein, pseudogene 376619000390 metabolite-proton symporter; Region: 2A0106; TIGR00883 376619000391 metabolite-proton symporter; Region: 2A0106; TIGR00883 376619000392 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000393 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000394 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000396 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 376619000397 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 376619000398 Ligand Binding Site [chemical binding]; other site 376619000399 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 376619000400 Ligand Binding Site [chemical binding]; other site 376619000401 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 376619000402 PLD-like domain; Region: PLDc_2; pfam13091 376619000403 putative homodimer interface [polypeptide binding]; other site 376619000404 putative active site [active] 376619000405 catalytic site [active] 376619000406 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 376619000407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 376619000408 ATP binding site [chemical binding]; other site 376619000409 putative Mg++ binding site [ion binding]; other site 376619000410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 376619000411 nucleotide binding region [chemical binding]; other site 376619000412 ATP-binding site [chemical binding]; other site 376619000413 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 376619000414 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 376619000415 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 376619000416 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 376619000417 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 376619000418 Mitochondrial PGP phosphatase; Region: PGP_phosphatase; pfam09419 376619000419 Predicted methyltransferases [General function prediction only]; Region: COG0313 376619000420 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 376619000421 putative SAM binding site [chemical binding]; other site 376619000422 putative homodimer interface [polypeptide binding]; other site 376619000423 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 376619000424 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 376619000425 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 376619000426 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 376619000427 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 376619000428 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 376619000429 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 376619000430 shikimate binding site; other site 376619000431 NAD(P) binding site [chemical binding]; other site 376619000432 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 376619000433 Ribonuclease P; Region: Ribonuclease_P; pfam00825 376619000434 hypothetical protein; Provisional; Region: PRK14375 376619000435 membrane protein insertase; Provisional; Region: PRK01318 376619000436 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 376619000437 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 376619000438 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 376619000439 putative acyl-acceptor binding pocket; other site 376619000440 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 376619000441 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 376619000442 putative acyl-acceptor binding pocket; other site 376619000443 elongation factor P; Validated; Region: PRK00529 376619000444 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 376619000445 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 376619000446 RNA binding site [nucleotide binding]; other site 376619000447 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 376619000448 RNA binding site [nucleotide binding]; other site 376619000449 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 376619000450 catalytic site [active] 376619000451 putative active site [active] 376619000452 putative substrate binding site [chemical binding]; other site 376619000453 dimer interface [polypeptide binding]; other site 376619000454 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000455 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000456 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619000459 putative substrate translocation pore; other site 376619000460 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 376619000461 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 376619000462 substrate binding pocket [chemical binding]; other site 376619000463 membrane-bound complex binding site; other site 376619000464 hinge residues; other site 376619000465 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 376619000466 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 376619000467 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 376619000468 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 376619000469 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 376619000470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619000471 Major Facilitator Superfamily; Region: MFS_1; pfam07690 376619000472 putative substrate translocation pore; other site 376619000473 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 376619000474 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 376619000475 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 376619000476 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 376619000477 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 376619000478 D-pathway; other site 376619000479 Putative ubiquinol binding site [chemical binding]; other site 376619000480 Low-spin heme (heme b) binding site [chemical binding]; other site 376619000481 Putative water exit pathway; other site 376619000482 Binuclear center (heme o3/CuB) [ion binding]; other site 376619000483 K-pathway; other site 376619000484 Putative proton exit pathway; other site 376619000485 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 376619000486 Subunit I/III interface [polypeptide binding]; other site 376619000487 Subunit III/IV interface [polypeptide binding]; other site 376619000488 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 376619000489 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 376619000490 UbiA prenyltransferase family; Region: UbiA; pfam01040 376619000491 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 376619000492 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 376619000493 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 376619000494 trimer interface [polypeptide binding]; other site 376619000495 active site 376619000496 UDP-GlcNAc binding site [chemical binding]; other site 376619000497 lipid binding site [chemical binding]; lipid-binding site 376619000498 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 376619000499 pyridoxamine kinase; Validated; Region: PRK05756 376619000500 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 376619000501 dimer interface [polypeptide binding]; other site 376619000502 pyridoxal binding site [chemical binding]; other site 376619000503 ATP binding site [chemical binding]; other site 376619000504 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 376619000505 MoxR-like ATPases [General function prediction only]; Region: COG0714 376619000506 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 376619000507 Walker A motif; other site 376619000508 ATP binding site [chemical binding]; other site 376619000509 Walker B motif; other site 376619000510 arginine finger; other site 376619000511 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 376619000512 Protein of unknown function DUF58; Region: DUF58; pfam01882 376619000513 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 376619000514 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 376619000515 metal ion-dependent adhesion site (MIDAS); other site 376619000516 hypothetical protein; Provisional; Region: PRK13685 376619000517 von Willebrand factor type A domain; Region: VWA_2; pfam13519 376619000518 metal ion-dependent adhesion site (MIDAS); other site 376619000519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 376619000520 Tetratricopeptide repeat; Region: TPR_16; pfam13432 376619000521 TPR motif; other site 376619000522 binding surface 376619000523 Oxygen tolerance; Region: BatD; pfam13584 376619000524 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 376619000525 putative substrate binding pocket [chemical binding]; other site 376619000526 AC domain interface; other site 376619000527 catalytic triad [active] 376619000528 AB domain interface; other site 376619000529 interchain disulfide; other site 376619000530 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 376619000531 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 376619000532 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 376619000533 active site 376619000534 HIGH motif; other site 376619000535 nucleotide binding site [chemical binding]; other site 376619000536 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 376619000537 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 376619000538 active site 376619000539 KMSKS motif; other site 376619000540 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 376619000541 tRNA binding surface [nucleotide binding]; other site 376619000542 anticodon binding site; other site 376619000543 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 376619000544 1-deoxy-D-xylulose-5-phosphate synthase; Region: PLN02225 376619000545 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 376619000546 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 376619000547 phosphate binding site [ion binding]; other site 376619000548 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 376619000549 dimer interface [polypeptide binding]; other site 376619000550 FMN binding site [chemical binding]; other site 376619000551 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 376619000552 nudix motif; other site 376619000553 fumarate hydratase; Reviewed; Region: fumC; PRK00485 376619000554 Class II fumarases; Region: Fumarase_classII; cd01362 376619000555 active site 376619000556 tetramer interface [polypeptide binding]; other site 376619000557 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 376619000558 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 376619000559 HIGH motif; other site 376619000560 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 376619000561 active site 376619000562 KMSKS motif; other site 376619000563 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619000564 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619000565 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619000566 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 376619000567 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 376619000568 Amidinotransferase; Region: Amidinotransf; pfam02274 376619000569 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 376619000570 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 376619000571 folate binding site [chemical binding]; other site 376619000572 NADP+ binding site [chemical binding]; other site 376619000573 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 376619000574 rRNA interaction site [nucleotide binding]; other site 376619000575 S8 interaction site; other site 376619000576 putative laminin-1 binding site; other site 376619000577 elongation factor Ts; Provisional; Region: tsf; PRK09377 376619000578 UBA/TS-N domain; Region: UBA; pfam00627 376619000579 Elongation factor TS; Region: EF_TS; pfam00889 376619000580 Elongation factor TS; Region: EF_TS; pfam00889 376619000581 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 376619000582 putative nucleotide binding site [chemical binding]; other site 376619000583 uridine monophosphate binding site [chemical binding]; other site 376619000584 homohexameric interface [polypeptide binding]; other site 376619000585 ribosome recycling factor; Reviewed; Region: frr; PRK00083 376619000586 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 376619000587 hinge region; other site 376619000588 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 376619000589 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 376619000590 catalytic residue [active] 376619000591 putative FPP diphosphate binding site; other site 376619000592 putative FPP binding hydrophobic cleft; other site 376619000593 dimer interface [polypeptide binding]; other site 376619000594 putative IPP diphosphate binding site; other site 376619000595 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 376619000596 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 376619000597 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 376619000598 trimer interface [polypeptide binding]; other site 376619000599 active site 376619000600 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 376619000601 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 376619000602 S17 interaction site [polypeptide binding]; other site 376619000603 S8 interaction site; other site 376619000604 16S rRNA interaction site [nucleotide binding]; other site 376619000605 streptomycin interaction site [chemical binding]; other site 376619000606 23S rRNA interaction site [nucleotide binding]; other site 376619000607 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 376619000608 30S ribosomal protein S7; Validated; Region: PRK05302 376619000609 elongation factor G; Reviewed; Region: PRK00007 376619000610 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 376619000611 G1 box; other site 376619000612 putative GEF interaction site [polypeptide binding]; other site 376619000613 GTP/Mg2+ binding site [chemical binding]; other site 376619000614 Switch I region; other site 376619000615 G2 box; other site 376619000616 G3 box; other site 376619000617 Switch II region; other site 376619000618 G4 box; other site 376619000619 G5 box; other site 376619000620 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 376619000621 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 376619000622 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 376619000623 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 376619000624 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 376619000625 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 376619000626 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 376619000627 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 376619000628 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 376619000629 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 376619000630 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 376619000631 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 376619000632 putative translocon binding site; other site 376619000633 protein-rRNA interface [nucleotide binding]; other site 376619000634 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 376619000635 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 376619000636 G-X-X-G motif; other site 376619000637 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 376619000638 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 376619000639 23S rRNA interface [nucleotide binding]; other site 376619000640 5S rRNA interface [nucleotide binding]; other site 376619000641 putative antibiotic binding site [chemical binding]; other site 376619000642 L25 interface [polypeptide binding]; other site 376619000643 L27 interface [polypeptide binding]; other site 376619000644 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 376619000645 23S rRNA interface [nucleotide binding]; other site 376619000646 putative translocon interaction site; other site 376619000647 signal recognition particle (SRP54) interaction site; other site 376619000648 L23 interface [polypeptide binding]; other site 376619000649 trigger factor interaction site; other site 376619000650 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 376619000651 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 376619000652 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 376619000653 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 376619000654 RNA binding site [nucleotide binding]; other site 376619000655 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 376619000656 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 376619000657 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 376619000658 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 376619000659 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 376619000660 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 376619000661 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 376619000662 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 376619000663 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 376619000664 23S rRNA interface [nucleotide binding]; other site 376619000665 L21e interface [polypeptide binding]; other site 376619000666 5S rRNA interface [nucleotide binding]; other site 376619000667 L27 interface [polypeptide binding]; other site 376619000668 L5 interface [polypeptide binding]; other site 376619000669 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 376619000670 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 376619000671 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 376619000672 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 376619000673 23S rRNA binding site [nucleotide binding]; other site 376619000674 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 376619000675 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 376619000676 SecY translocase; Region: SecY; pfam00344 376619000677 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 376619000678 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 376619000679 30S ribosomal protein S13; Region: bact_S13; TIGR03631 376619000680 30S ribosomal protein S11; Validated; Region: PRK05309 376619000681 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 376619000682 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 376619000683 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 376619000684 RNA binding surface [nucleotide binding]; other site 376619000685 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 376619000686 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 376619000687 alphaNTD homodimer interface [polypeptide binding]; other site 376619000688 alphaNTD - beta interaction site [polypeptide binding]; other site 376619000689 alphaNTD - beta' interaction site [polypeptide binding]; other site 376619000690 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 376619000691 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 376619000692 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000693 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000694 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000695 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000696 Transposase, fragment 376619000697 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 376619000698 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000699 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000700 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000701 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000702 heat shock protein 90; Provisional; Region: PRK05218 376619000703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 376619000704 ATP binding site [chemical binding]; other site 376619000705 Mg2+ binding site [ion binding]; other site 376619000706 G-X-G motif; other site 376619000707 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000708 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000709 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000711 glutamate dehydrogenase; Provisional; Region: PRK09414 376619000712 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 376619000713 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 376619000714 NAD(P) binding site [chemical binding]; other site 376619000715 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619000716 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619000717 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619000718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 376619000719 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 376619000720 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 376619000721 active site 376619000722 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 376619000723 substrate binding site [chemical binding]; other site 376619000724 catalytic residues [active] 376619000725 dimer interface [polypeptide binding]; other site 376619000726 Amino acid permease; Region: AA_permease_2; pfam13520 376619000727 conserved hypothetical protein, pseudogene 376619000728 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 376619000729 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 376619000730 DNA binding site [nucleotide binding] 376619000731 active site 376619000732 Uncharacterized conserved protein [Function unknown]; Region: COG0398 376619000733 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 376619000734 mercuric reductase; Validated; Region: PRK06370 376619000735 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 376619000736 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 376619000737 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 376619000738 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 376619000739 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 376619000740 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 376619000741 HSP70 interaction site [polypeptide binding]; other site 376619000742 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 376619000743 substrate binding site [polypeptide binding]; other site 376619000744 dimer interface [polypeptide binding]; other site 376619000745 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 376619000746 EamA-like transporter family; Region: EamA; pfam00892 376619000747 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 376619000748 Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; Region: PI3Ka; cl00271 376619000749 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 376619000750 HD domain; Region: HD_4; pfam13328 376619000751 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 376619000752 synthetase active site [active] 376619000753 NTP binding site [chemical binding]; other site 376619000754 metal binding site [ion binding]; metal-binding site 376619000755 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 376619000756 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 376619000757 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 376619000758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 376619000759 S-adenosylmethionine binding site [chemical binding]; other site 376619000760 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 376619000761 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 376619000762 active site 376619000763 DNA binding site [nucleotide binding] 376619000764 Int/Topo IB signature motif; other site 376619000765 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 376619000766 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 376619000767 conserved hypothetical protein, pseudogene 376619000768 preprotein translocase subunit SecB; Validated; Region: PRK05751 376619000769 SecA binding site; other site 376619000770 Preprotein binding site; other site 376619000771 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 376619000772 MutS domain I; Region: MutS_I; pfam01624 376619000773 MutS domain III; Region: MutS_III; pfam05192 376619000774 MutS domain V; Region: MutS_V; pfam00488 376619000775 Walker A/P-loop; other site 376619000776 ATP binding site [chemical binding]; other site 376619000777 Q-loop/lid; other site 376619000778 ABC transporter signature motif; other site 376619000779 Walker B; other site 376619000780 D-loop; other site 376619000781 H-loop/switch region; other site 376619000782 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 376619000783 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 376619000784 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 376619000785 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 376619000786 putative active site [active] 376619000787 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890 376619000788 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619000789 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619000790 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619000791 Zeta toxin; Region: Zeta_toxin; pfam06414 376619000792 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 376619000793 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 376619000794 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 376619000795 active site 376619000796 HIGH motif; other site 376619000797 dimer interface [polypeptide binding]; other site 376619000798 KMSKS motif; other site 376619000799 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 376619000800 dephospho-CoA kinase; Region: TIGR00152 376619000801 CoA-binding site [chemical binding]; other site 376619000802 ATP-binding [chemical binding]; other site 376619000803 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 376619000804 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 376619000805 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 376619000806 dimer interface [polypeptide binding]; other site 376619000807 TPP-binding site [chemical binding]; other site 376619000808 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 376619000809 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 376619000810 E3 interaction surface; other site 376619000811 lipoyl attachment site [posttranslational modification]; other site 376619000812 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 376619000813 E3 interaction surface; other site 376619000814 lipoyl attachment site [posttranslational modification]; other site 376619000815 e3 binding domain; Region: E3_binding; pfam02817 376619000816 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 376619000817 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 376619000818 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 376619000819 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 376619000820 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 376619000821 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 376619000822 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 376619000823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 376619000824 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000825 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000827 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 376619000828 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 376619000829 nudix motif; other site 376619000830 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 376619000831 ArsC family; Region: ArsC; pfam03960 376619000832 catalytic residue [active] 376619000833 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 376619000834 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 376619000835 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 376619000836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 376619000837 homodimer interface [polypeptide binding]; other site 376619000838 catalytic residue [active] 376619000839 hypothetical protein 376619000840 Aspartate:alanine antiporter 376619000841 Smf protein DNA processing chain A, pseudogene 376619000842 hypothetical protein 376619000843 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 376619000844 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 376619000845 ligand binding site [chemical binding]; other site 376619000846 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 376619000847 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 376619000848 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 376619000849 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 376619000850 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 376619000851 homotrimer interaction site [polypeptide binding]; other site 376619000852 active site 376619000853 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 376619000854 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 376619000855 TolQ protein; Region: tolQ; TIGR02796 376619000856 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 376619000857 TolR protein; Region: tolR; TIGR02801 376619000858 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 376619000859 TolB amino-terminal domain; Region: TolB_N; pfam04052 376619000860 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 376619000861 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 376619000862 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 376619000863 ligand binding site [chemical binding]; other site 376619000864 conserved hypothetical protein, pseudogene 376619000865 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 376619000866 Coenzyme A binding pocket [chemical binding]; other site 376619000867 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000868 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000869 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000871 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 376619000872 DNA photolyase; Region: DNA_photolyase; pfam00875 376619000873 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 376619000874 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 376619000875 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 376619000876 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 376619000877 bile acid transporter; Region: bass; TIGR00841 376619000878 Sodium Bile acid symporter family; Region: SBF; cl17470 376619000879 YheO-like PAS domain; Region: PAS_6; pfam08348 376619000880 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 376619000881 hypothetical protein; Provisional; Region: PRK10621 376619000882 conserved hypothetical protein, pseudogene 376619000883 hypothetical protein 376619000884 arsenite permease family protein 376619000885 arsenite permease 376619000886 Protein of unknown function (DUF423); Region: DUF423; pfam04241 376619000887 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619000888 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619000889 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619000890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619000891 Protein of unknown function, DUF393; Region: DUF393; pfam04134 376619000892 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 376619000893 UbiA prenyltransferase family; Region: UbiA; pfam01040 376619000894 Chorismate lyase; Region: Chor_lyase; cl01230 376619000895 ribonuclease PH; Reviewed; Region: rph; PRK00173 376619000896 Ribonuclease PH; Region: RNase_PH_bact; cd11362 376619000897 hexamer interface [polypeptide binding]; other site 376619000898 active site 376619000899 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 376619000900 heat shock protein HtpX; Provisional; Region: PRK02870 376619000901 LemA family; Region: LemA; cl00742 376619000902 hypothetical protein 376619000903 transcriptional regulator, LysR family 376619000904 conserved hypothetical protein 376619000905 conserved hypothetical protein, pseudogene 376619000906 haloacid dehalogenase-like hydrolase 376619000907 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619000908 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619000909 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619000910 Cadmium-transporting ATPase (pseudogene) 376619000911 hypothetical protein 376619000912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 376619000913 putative Zn2+ binding site [ion binding]; other site 376619000914 putative DNA binding site [nucleotide binding]; other site 376619000915 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 376619000916 putative active site [active] 376619000917 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 376619000918 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 376619000919 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 376619000920 Colicin V production protein; Region: Colicin_V; pfam02674 376619000921 DNA repair protein RadA; Provisional; Region: PRK11823 376619000922 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 376619000923 Walker A motif/ATP binding site; other site 376619000924 ATP binding site [chemical binding]; other site 376619000925 Walker B motif; other site 376619000926 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 376619000927 PilZ domain; Region: PilZ; pfam07238 376619000928 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 376619000929 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 376619000930 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 376619000931 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 376619000932 Tetramer interface [polypeptide binding]; other site 376619000933 active site 376619000934 FMN-binding site [chemical binding]; other site 376619000935 PQ loop repeat; Region: PQ-loop; pfam04193 376619000936 methionine sulfoxide reductase B; Provisional; Region: PRK00222 376619000937 SelR domain; Region: SelR; pfam01641 376619000938 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 376619000939 E-class dimer interface [polypeptide binding]; other site 376619000940 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 376619000941 P-class dimer interface [polypeptide binding]; other site 376619000942 active site 376619000943 Cu2+ binding site [ion binding]; other site 376619000944 Zn2+ binding site [ion binding]; other site 376619000945 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 376619000946 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 376619000947 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 376619000948 Cupin domain; Region: Cupin_2; cl17218 376619000949 glutathione dependent formaldehyde dehydrogenase 376619000950 alcohol dehydrogenase class III, pseudogene 376619000951 glutathione dependent formaldehyde dehydrogenase 376619000952 aspartate aminotransferase; Provisional; Region: PRK07568 376619000953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 376619000954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 376619000955 homodimer interface [polypeptide binding]; other site 376619000956 catalytic residue [active] 376619000957 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 376619000958 Cation efflux family; Region: Cation_efflux; pfam01545 376619000959 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 376619000960 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 376619000961 Walker A/P-loop; other site 376619000962 ATP binding site [chemical binding]; other site 376619000963 Q-loop/lid; other site 376619000964 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 376619000965 ABC transporter signature motif; other site 376619000966 Walker B; other site 376619000967 D-loop; other site 376619000968 H-loop/switch region; other site 376619000969 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 376619000970 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 376619000971 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 376619000972 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 376619000973 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 376619000974 active site 376619000975 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 376619000976 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 376619000977 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 376619000978 homodimer interface [polypeptide binding]; other site 376619000979 NADP binding site [chemical binding]; other site 376619000980 substrate binding site [chemical binding]; other site 376619000981 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 376619000982 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 376619000983 dimerization interface [polypeptide binding]; other site 376619000984 putative ATP binding site [chemical binding]; other site 376619000985 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 376619000986 active site 376619000987 ATP binding site [chemical binding]; other site 376619000988 substrate binding site [chemical binding]; other site 376619000989 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 376619000990 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 376619000991 ATP-grasp domain; Region: ATP-grasp_4; cl17255 376619000992 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 376619000993 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 376619000994 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 376619000995 active site 376619000996 substrate binding site [chemical binding]; other site 376619000997 cosubstrate binding site; other site 376619000998 catalytic site [active] 376619000999 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 376619001000 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 376619001001 ATP-grasp domain; Region: ATP-grasp; pfam02222 376619001002 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619001003 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619001004 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619001005 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 376619001006 intracellular septation protein A; Reviewed; Region: PRK00259 376619001007 Glucokinase; Region: Glucokinase; pfam02685 376619001008 glucokinase, proteobacterial type; Region: glk; TIGR00749 376619001009 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 376619001010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 376619001011 S-adenosylmethionine binding site [chemical binding]; other site 376619001012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 376619001013 ABC1 family; Region: ABC1; cl17513 376619001014 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 376619001015 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 376619001016 nucleotide binding site/active site [active] 376619001017 HIT family signature motif; other site 376619001018 catalytic residue [active] 376619001019 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 376619001020 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 376619001021 active site 376619001022 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 376619001023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 376619001024 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 376619001025 FAD binding domain; Region: FAD_binding_4; pfam01565 376619001026 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 376619001027 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 376619001028 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 376619001029 putative active site [active] 376619001030 GTP-binding protein Der; Reviewed; Region: PRK00093 376619001031 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 376619001032 G1 box; other site 376619001033 GTP/Mg2+ binding site [chemical binding]; other site 376619001034 Switch I region; other site 376619001035 G2 box; other site 376619001036 Switch II region; other site 376619001037 G3 box; other site 376619001038 G4 box; other site 376619001039 G5 box; other site 376619001040 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 376619001041 G1 box; other site 376619001042 GTP/Mg2+ binding site [chemical binding]; other site 376619001043 Switch I region; other site 376619001044 G2 box; other site 376619001045 G3 box; other site 376619001046 Switch II region; other site 376619001047 G4 box; other site 376619001048 G5 box; other site 376619001049 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619001050 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619001051 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619001052 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619001053 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619001054 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619001055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619001056 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 376619001057 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 376619001058 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 376619001059 active site 376619001060 Zn binding site [ion binding]; other site 376619001061 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 376619001062 hypothetical protein 376619001063 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 376619001064 DNA topoisomerase I; Validated; Region: PRK06599 376619001065 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 376619001066 active site 376619001067 interdomain interaction site; other site 376619001068 putative metal-binding site [ion binding]; other site 376619001069 nucleotide binding site [chemical binding]; other site 376619001070 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 376619001071 domain I; other site 376619001072 DNA binding groove [nucleotide binding] 376619001073 phosphate binding site [ion binding]; other site 376619001074 domain II; other site 376619001075 domain III; other site 376619001076 nucleotide binding site [chemical binding]; other site 376619001077 catalytic site [active] 376619001078 domain IV; other site 376619001079 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 376619001080 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 376619001081 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 376619001082 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 376619001083 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 376619001084 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 376619001085 P-loop; other site 376619001086 Magnesium ion binding site [ion binding]; other site 376619001087 ParB-like nuclease domain; Region: ParB; smart00470 376619001088 KorB domain; Region: KorB; pfam08535 376619001089 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 376619001090 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 376619001091 catalytic triad [active] 376619001092 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 376619001093 active site 376619001094 catalytic triad [active] 376619001095 oxyanion hole [active] 376619001096 HD domain; Region: HD_3; pfam13023 376619001097 HD domain; Region: HD_3; cl17350 376619001098 FtsJ-like methyltransferase; Region: FtsJ; cl17430 376619001099 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 376619001100 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 376619001101 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 376619001102 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 376619001103 active site 376619001104 HIGH motif; other site 376619001105 nucleotide binding site [chemical binding]; other site 376619001106 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 376619001107 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 376619001108 active site 376619001109 KMSKS motif; other site 376619001110 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 376619001111 tRNA binding surface [nucleotide binding]; other site 376619001112 anticodon binding site; other site 376619001113 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 376619001114 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 376619001115 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 376619001116 active site 376619001117 Riboflavin kinase; Region: Flavokinase; pfam01687 376619001118 malate dehydrogenase; Provisional; Region: PRK13529 376619001119 Malic enzyme, N-terminal domain; Region: malic; pfam00390 376619001120 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 376619001121 NAD(P) binding pocket [chemical binding]; other site 376619001122 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 376619001123 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619001124 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619001125 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619001126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619001127 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619001128 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619001129 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619001130 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 376619001131 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 376619001132 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 376619001133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619001134 D-galactonate transporter; Region: 2A0114; TIGR00893 376619001135 putative substrate translocation pore; other site 376619001136 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 376619001137 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 376619001138 active site 376619001139 HIGH motif; other site 376619001140 KMSKS motif; other site 376619001141 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 376619001142 tRNA binding surface [nucleotide binding]; other site 376619001143 anticodon binding site; other site 376619001144 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 376619001145 dimer interface [polypeptide binding]; other site 376619001146 putative tRNA-binding site [nucleotide binding]; other site 376619001147 Predicted flavoprotein [General function prediction only]; Region: COG0431 376619001148 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 376619001149 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 376619001150 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 376619001151 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 376619001152 Peptidase family M50; Region: Peptidase_M50; pfam02163 376619001153 active site 376619001154 putative substrate binding region [chemical binding]; other site 376619001155 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 376619001156 DNA binding residues [nucleotide binding] 376619001157 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 376619001158 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 376619001159 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 376619001160 active site 376619001161 (T/H)XGH motif; other site 376619001162 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 376619001163 nudix motif; other site 376619001164 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 376619001165 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 376619001166 Substrate binding site; other site 376619001167 Mg++ binding site; other site 376619001168 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 376619001169 active site 376619001170 substrate binding site [chemical binding]; other site 376619001171 CoA binding site [chemical binding]; other site 376619001172 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 376619001173 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 376619001174 glutaminase active site [active] 376619001175 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 376619001176 dimer interface [polypeptide binding]; other site 376619001177 active site 376619001178 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 376619001179 dimer interface [polypeptide binding]; other site 376619001180 active site 376619001181 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 376619001182 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 376619001183 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 376619001184 DNA-binding site [nucleotide binding]; DNA binding site 376619001185 RNA-binding motif; other site 376619001186 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 376619001187 metal binding site [ion binding]; metal-binding site 376619001188 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 376619001189 active site 376619001190 PLD-like domain; Region: PLDc_2; pfam13091 376619001191 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 376619001192 putative homodimer interface [polypeptide binding]; other site 376619001193 putative active site [active] 376619001194 catalytic site [active] 376619001195 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 376619001196 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 376619001197 CAP-like domain; other site 376619001198 active site 376619001199 primary dimer interface [polypeptide binding]; other site 376619001200 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 376619001201 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 376619001202 BNR repeat-like domain; Region: BNR_2; pfam13088 376619001203 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 376619001204 Asp-box motif; other site 376619001205 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 376619001206 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 376619001207 N-acetyl-D-glucosamine binding site [chemical binding]; other site 376619001208 catalytic residue [active] 376619001209 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 376619001210 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619001211 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619001212 Predicted membrane protein [Function unknown]; Region: COG4325 376619001213 Predicted membrane protein [Function unknown]; Region: COG4325 376619001214 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 376619001215 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 376619001216 putative active site [active] 376619001217 putative PHP Thumb interface [polypeptide binding]; other site 376619001218 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 376619001219 generic binding surface II; other site 376619001220 generic binding surface I; other site 376619001221 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 376619001222 active site 376619001223 catalytic residues [active] 376619001224 metal binding site [ion binding]; metal-binding site 376619001225 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 376619001226 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 376619001227 FtsX-like permease family; Region: FtsX; pfam02687 376619001228 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 376619001229 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 376619001230 Walker A/P-loop; other site 376619001231 ATP binding site [chemical binding]; other site 376619001232 Q-loop/lid; other site 376619001233 ABC transporter signature motif; other site 376619001234 Walker B; other site 376619001235 D-loop; other site 376619001236 H-loop/switch region; other site 376619001237 lysine decarboxylase LdcC; Provisional; Region: PRK15399 376619001238 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 376619001239 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 376619001240 homodimer interface [polypeptide binding]; other site 376619001241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 376619001242 catalytic residue [active] 376619001243 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 376619001244 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 376619001245 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 376619001246 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 376619001247 lipoyl attachment site [posttranslational modification]; other site 376619001248 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 376619001249 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 376619001250 tetramer interface [polypeptide binding]; other site 376619001251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 376619001252 catalytic residue [active] 376619001253 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 376619001254 tetramer interface [polypeptide binding]; other site 376619001255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 376619001256 catalytic residue [active] 376619001257 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 376619001258 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 376619001259 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 376619001260 shikimate binding site; other site 376619001261 NAD(P) binding site [chemical binding]; other site 376619001262 pullulanase, type I; Region: pulA_typeI; TIGR02104 376619001263 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 376619001264 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 376619001265 Ca binding site [ion binding]; other site 376619001266 active site 376619001267 catalytic site [active] 376619001268 glycogen branching enzyme; Provisional; Region: PRK12313 376619001269 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 376619001270 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 376619001271 active site 376619001272 catalytic site [active] 376619001273 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 376619001274 phosphoglucomutase; Region: PLN02307 376619001275 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 376619001276 substrate binding site [chemical binding]; other site 376619001277 dimer interface [polypeptide binding]; other site 376619001278 active site 376619001279 metal binding site [ion binding]; metal-binding site 376619001280 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 376619001281 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 376619001282 ligand binding site; other site 376619001283 oligomer interface; other site 376619001284 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 376619001285 dimer interface [polypeptide binding]; other site 376619001286 N-terminal domain interface [polypeptide binding]; other site 376619001287 sulfate 1 binding site; other site 376619001288 glycogen synthase; Provisional; Region: glgA; PRK00654 376619001289 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 376619001290 ADP-binding pocket [chemical binding]; other site 376619001291 homodimer interface [polypeptide binding]; other site 376619001292 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 376619001293 homodimer interface [polypeptide binding]; other site 376619001294 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 376619001295 active site pocket [active] 376619001296 4-alpha-glucanotransferase; Provisional; Region: PRK14508 376619001297 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 376619001298 dimer interface [polypeptide binding]; other site 376619001299 motif 1; other site 376619001300 active site 376619001301 motif 2; other site 376619001302 motif 3; other site 376619001303 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 376619001304 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 376619001305 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 376619001306 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 376619001307 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 376619001308 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 376619001309 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 376619001310 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 376619001311 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 376619001312 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 376619001313 aspartokinase/homoserine dehydrogenase 376619001314 homoserine kinase 376619001315 homoserine kinase 376619001316 threonine synthase; Validated; Region: PRK09225 376619001317 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 376619001318 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 376619001319 catalytic residue [active] 376619001320 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 376619001321 spermidine synthase; Provisional; Region: PRK00811 376619001322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 376619001323 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 376619001324 active site 376619001325 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 376619001326 dimer interface [polypeptide binding]; other site 376619001327 substrate binding site [chemical binding]; other site 376619001328 catalytic residues [active] 376619001329 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 376619001330 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619001331 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619001332 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619001333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619001334 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 376619001335 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 376619001336 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 376619001337 putative active site [active] 376619001338 putative metal binding site [ion binding]; other site 376619001339 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 376619001340 active site 376619001341 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 376619001342 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 376619001343 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 376619001344 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 376619001345 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 376619001346 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 376619001347 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619001348 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619001349 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619001350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619001351 BolA-like protein; Region: BolA; cl00386 376619001352 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 376619001353 anti sigma factor interaction site; other site 376619001354 regulatory phosphorylation site [posttranslational modification]; other site 376619001355 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 376619001356 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 376619001357 mce related protein; Region: MCE; pfam02470 376619001358 Permease; Region: Permease; pfam02405 376619001359 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 376619001360 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 376619001361 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 376619001362 Walker A/P-loop; other site 376619001363 ATP binding site [chemical binding]; other site 376619001364 Q-loop/lid; other site 376619001365 ABC transporter signature motif; other site 376619001366 Walker B; other site 376619001367 D-loop; other site 376619001368 H-loop/switch region; other site 376619001369 cell division topological specificity factor MinE; Provisional; Region: PRK13990 376619001370 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 376619001371 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 376619001372 Switch I; other site 376619001373 Switch II; other site 376619001374 septum formation inhibitor; Reviewed; Region: minC; PRK04804 376619001375 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 376619001376 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 376619001377 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 376619001378 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 376619001379 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 376619001380 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 376619001381 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 376619001382 ssDNA binding site; other site 376619001383 generic binding surface II; other site 376619001384 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 376619001385 ATP binding site [chemical binding]; other site 376619001386 putative Mg++ binding site [ion binding]; other site 376619001387 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 376619001388 nucleotide binding region [chemical binding]; other site 376619001389 ATP-binding site [chemical binding]; other site 376619001390 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 376619001391 Fumarase C-terminus; Region: Fumerase_C; pfam05683 376619001392 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619001393 Homeodomain-like domain; Region: HTH_23; cl17451 376619001394 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 376619001395 GIY-YIG motif/motif A; other site 376619001396 putative active site [active] 376619001397 putative metal binding site [ion binding]; other site 376619001398 Restriction endonuclease [Defense mechanisms]; Region: COG3587 376619001399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 376619001400 ATP binding site [chemical binding]; other site 376619001401 putative Mg++ binding site [ion binding]; other site 376619001402 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 376619001403 ligand binding site [chemical binding]; other site 376619001404 active site 376619001405 UGI interface [polypeptide binding]; other site 376619001406 catalytic site [active] 376619001407 DNA gyrase subunit A; Validated; Region: PRK05560 376619001408 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 376619001409 CAP-like domain; other site 376619001410 active site 376619001411 primary dimer interface [polypeptide binding]; other site 376619001412 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 376619001413 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 376619001414 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 376619001415 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 376619001416 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 376619001417 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 376619001418 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 376619001419 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 376619001420 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 376619001421 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 376619001422 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 376619001423 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 376619001424 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 376619001425 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 376619001426 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 376619001427 Surface antigen; Region: Bac_surface_Ag; pfam01103 376619001428 periplasmic chaperone; Provisional; Region: PRK10780 376619001429 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 376619001430 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 376619001431 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 376619001432 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 376619001433 trimer interface [polypeptide binding]; other site 376619001434 active site 376619001435 UDP-GlcNAc binding site [chemical binding]; other site 376619001436 lipid binding site [chemical binding]; lipid-binding site 376619001437 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 376619001438 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 376619001439 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 376619001440 active site 376619001441 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 376619001442 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 376619001443 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 376619001444 active site 376619001445 glycosyl hydrolase, family 3, pseudogene 376619001446 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 376619001447 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 376619001448 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 376619001449 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 376619001450 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 376619001451 substrate binding pocket [chemical binding]; other site 376619001452 chain length determination region; other site 376619001453 substrate-Mg2+ binding site; other site 376619001454 catalytic residues [active] 376619001455 aspartate-rich region 1; other site 376619001456 active site lid residues [active] 376619001457 aspartate-rich region 2; other site 376619001458 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 376619001459 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 376619001460 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 376619001461 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 376619001462 active site 376619001463 dimerization interface [polypeptide binding]; other site 376619001464 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 376619001465 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 376619001466 conserved hypothetical protein 376619001467 conserved hypothetical protein, pseudogene 376619001468 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 376619001469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 376619001470 active site 376619001471 phosphorylation site [posttranslational modification] 376619001472 intermolecular recognition site; other site 376619001473 dimerization interface [polypeptide binding]; other site 376619001474 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 376619001475 DNA binding site [nucleotide binding] 376619001476 signal peptidase I; Provisional; Region: PRK10861 376619001477 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 376619001478 Catalytic site [active] 376619001479 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 376619001480 ribonuclease III; Reviewed; Region: rnc; PRK00102 376619001481 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 376619001482 dimerization interface [polypeptide binding]; other site 376619001483 active site 376619001484 metal binding site [ion binding]; metal-binding site 376619001485 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 376619001486 dsRNA binding site [nucleotide binding]; other site 376619001487 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 376619001488 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 376619001489 RNA binding site [nucleotide binding]; other site 376619001490 active site 376619001491 ribonuclease R; Region: RNase_R; TIGR02063 376619001492 RNB domain; Region: RNB; pfam00773 376619001493 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 376619001494 RNA binding site [nucleotide binding]; other site 376619001495 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 376619001496 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 376619001497 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 376619001498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 376619001499 NAD(P) binding site [chemical binding]; other site 376619001500 active site 376619001501 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 376619001502 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 376619001503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 376619001504 S-adenosylmethionine binding site [chemical binding]; other site 376619001505 conserved hypothetical protein, pseudogene 376619001506 conserved hypothetical protein, pseudogene 376619001507 Two-component sensor histidine kinase, pseudogene 376619001508 hypothetical protein 376619001509 two component response regulator 376619001510 hypothetical protein 376619001511 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619001512 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619001513 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619001514 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 376619001515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 376619001516 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619001517 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619001518 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619001519 Amidinotransferase; Region: Amidinotransf; pfam02274 376619001520 Amidinotransferase; Region: Amidinotransf; cl12043 376619001521 ornithine cyclodeaminase; Validated; Region: PRK07589 376619001522 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 376619001523 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 376619001524 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 376619001525 active site 376619001526 Protein of unknown function (DUF465); Region: DUF465; pfam04325 376619001527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619001528 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 376619001529 putative substrate translocation pore; other site 376619001530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 376619001531 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 376619001532 CoenzymeA binding site [chemical binding]; other site 376619001533 subunit interaction site [polypeptide binding]; other site 376619001534 PHB binding site; other site 376619001535 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 376619001536 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 376619001537 dimer interface [polypeptide binding]; other site 376619001538 active site 376619001539 Acyl CoA binding protein; Region: ACBP; pfam00887 376619001540 acyl-CoA binding pocket [chemical binding]; other site 376619001541 CoA binding site [chemical binding]; other site 376619001542 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 376619001543 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 376619001544 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 376619001545 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 376619001546 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 376619001547 substrate binding site [chemical binding]; other site 376619001548 oxyanion hole (OAH) forming residues; other site 376619001549 trimer interface [polypeptide binding]; other site 376619001550 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 376619001551 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 376619001552 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 376619001553 active site 376619001554 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 376619001555 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 376619001556 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 376619001557 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 376619001558 acyl-activating enzyme (AAE) consensus motif; other site 376619001559 AMP binding site [chemical binding]; other site 376619001560 active site 376619001561 CoA binding site [chemical binding]; other site 376619001562 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 376619001563 ArsC family; Region: ArsC; pfam03960 376619001564 catalytic residues [active] 376619001565 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 376619001566 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 376619001567 DEAD-like helicases superfamily; Region: DEXDc; smart00487 376619001568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 376619001569 ATP binding site [chemical binding]; other site 376619001570 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 376619001571 putative Mg++ binding site [ion binding]; other site 376619001572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 376619001573 nucleotide binding region [chemical binding]; other site 376619001574 ATP-binding site [chemical binding]; other site 376619001575 Helicase associated domain (HA2); Region: HA2; pfam04408 376619001576 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 376619001577 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 376619001578 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 376619001579 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619001580 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619001581 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619001582 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 376619001583 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 376619001584 NAD(P) binding site [chemical binding]; other site 376619001585 homodimer interface [polypeptide binding]; other site 376619001586 substrate binding site [chemical binding]; other site 376619001587 active site 376619001588 Bacterial sugar transferase; Region: Bac_transf; pfam02397 376619001589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 376619001590 NADH(P)-binding; Region: NAD_binding_10; pfam13460 376619001591 NAD(P) binding site [chemical binding]; other site 376619001592 active site 376619001593 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 376619001594 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 376619001595 putative ADP-binding pocket [chemical binding]; other site 376619001596 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 376619001597 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 376619001598 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 376619001599 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 376619001600 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 376619001601 NAD binding site [chemical binding]; other site 376619001602 substrate binding site [chemical binding]; other site 376619001603 homodimer interface [polypeptide binding]; other site 376619001604 active site 376619001605 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 376619001606 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 376619001607 putative ADP-binding pocket [chemical binding]; other site 376619001608 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 376619001609 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 376619001610 active site 376619001611 dimer interface [polypeptide binding]; other site 376619001612 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 376619001613 Ligand Binding Site [chemical binding]; other site 376619001614 Molecular Tunnel; other site 376619001615 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 376619001616 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 376619001617 inhibitor-cofactor binding pocket; inhibition site 376619001618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 376619001619 catalytic residue [active] 376619001620 hypothetical protein; Provisional; Region: PRK07579 376619001621 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 376619001622 active site 376619001623 cosubstrate binding site; other site 376619001624 substrate binding site [chemical binding]; other site 376619001625 catalytic site [active] 376619001626 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 376619001627 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 376619001628 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 376619001629 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 376619001630 active site 376619001631 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 376619001632 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 376619001633 substrate binding site; other site 376619001634 tetramer interface; other site 376619001635 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 376619001636 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 376619001637 NAD binding site [chemical binding]; other site 376619001638 substrate binding site [chemical binding]; other site 376619001639 homodimer interface [polypeptide binding]; other site 376619001640 active site 376619001641 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619001642 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619001643 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619001644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619001645 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 376619001646 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 376619001647 Substrate binding site; other site 376619001648 Cupin domain; Region: Cupin_2; cl17218 376619001649 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 376619001650 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 376619001651 active site 376619001652 substrate binding site [chemical binding]; other site 376619001653 metal binding site [ion binding]; metal-binding site 376619001654 transcription termination factor Rho; Provisional; Region: rho; PRK09376 376619001655 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 376619001656 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 376619001657 RNA binding site [nucleotide binding]; other site 376619001658 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 376619001659 multimer interface [polypeptide binding]; other site 376619001660 Walker A motif; other site 376619001661 ATP binding site [chemical binding]; other site 376619001662 Walker B motif; other site 376619001663 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 376619001664 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 376619001665 catalytic residues [active] 376619001666 exopolyphosphatase; Region: exo_poly_only; TIGR03706 376619001667 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 376619001668 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619001669 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619001670 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619001671 conserved hypothetical protein (putative ATP/GTP binding protein) 376619001672 recombination factor protein RarA; Provisional; Region: PRK14700 376619001673 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 376619001674 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 376619001675 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 376619001676 dimer interface [polypeptide binding]; other site 376619001677 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 376619001678 Ferritin-like domain; Region: Ferritin; pfam00210 376619001679 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 376619001680 dinuclear metal binding motif [ion binding]; other site 376619001681 hypothetical protein 376619001682 major facilitator superfamily (MFS) transport protein, pseudogene 376619001683 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 376619001684 active site 376619001685 conserved hypothetical membrane, pseudogene 376619001686 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619001687 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619001688 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619001689 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 376619001690 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 376619001691 Walker A/P-loop; other site 376619001692 ATP binding site [chemical binding]; other site 376619001693 Q-loop/lid; other site 376619001694 ABC transporter signature motif; other site 376619001695 Walker B; other site 376619001696 D-loop; other site 376619001697 H-loop/switch region; other site 376619001698 inner membrane transport permease; Provisional; Region: PRK15066 376619001699 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 376619001700 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 376619001701 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 376619001702 Ligand binding site; other site 376619001703 Putative Catalytic site; other site 376619001704 DXD motif; other site 376619001705 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 376619001706 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 376619001707 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 376619001708 Methyltransferase, fragment 376619001709 conserved hypothetical protein, pseudogene 376619001710 Acetyltransferase 376619001711 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619001712 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619001713 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619001714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619001715 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 376619001716 putative DNA binding site [nucleotide binding]; other site 376619001717 putative Zn2+ binding site [ion binding]; other site 376619001718 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 376619001719 active site residue [active] 376619001720 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 376619001721 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 376619001722 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 376619001723 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 376619001724 active site residue [active] 376619001725 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 376619001726 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 376619001727 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 376619001728 hypothetical protein; Provisional; Region: PRK05170 376619001729 transcription antitermination factor NusB; Region: nusB; TIGR01951 376619001730 putative RNA binding site [nucleotide binding]; other site 376619001731 C-N hydrolase family amidase; Provisional; Region: PRK10438 376619001732 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 376619001733 putative active site [active] 376619001734 catalytic triad [active] 376619001735 dimer interface [polypeptide binding]; other site 376619001736 multimer interface [polypeptide binding]; other site 376619001737 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 376619001738 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 376619001739 homodimer interface [polypeptide binding]; other site 376619001740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 376619001741 catalytic residue [active] 376619001742 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 376619001743 prolyl-tRNA synthetase; Provisional; Region: PRK09194 376619001744 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 376619001745 dimer interface [polypeptide binding]; other site 376619001746 motif 1; other site 376619001747 active site 376619001748 motif 2; other site 376619001749 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 376619001750 putative deacylase active site [active] 376619001751 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 376619001752 active site 376619001753 motif 3; other site 376619001754 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 376619001755 anticodon binding site; other site 376619001756 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 376619001757 Fe-S metabolism associated domain; Region: SufE; cl00951 376619001758 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 376619001759 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 376619001760 active site 376619001761 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 376619001762 Sporulation related domain; Region: SPOR; pfam05036 376619001763 FeoA domain; Region: FeoA; cl00838 376619001764 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 376619001765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 376619001766 non-specific DNA binding site [nucleotide binding]; other site 376619001767 salt bridge; other site 376619001768 sequence-specific DNA binding site [nucleotide binding]; other site 376619001769 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 376619001770 Catalytic site [active] 376619001771 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 376619001772 EamA-like transporter family; Region: EamA; pfam00892 376619001773 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 376619001774 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 376619001775 active site 376619001776 FMN binding site [chemical binding]; other site 376619001777 substrate binding site [chemical binding]; other site 376619001778 3Fe-4S cluster binding site [ion binding]; other site 376619001779 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 376619001780 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 376619001781 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 376619001782 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 376619001783 Divergent AAA domain; Region: AAA_4; pfam04326 376619001784 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 376619001785 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 376619001786 putative DNA binding site [nucleotide binding]; other site 376619001787 putative Zn2+ binding site [ion binding]; other site 376619001788 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 376619001789 Family description; Region: UvrD_C_2; pfam13538 376619001790 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 376619001791 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 376619001792 AAA domain; Region: AAA_30; pfam13604 376619001793 Family description; Region: UvrD_C_2; pfam13538 376619001794 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 376619001795 nucleotide binding site [chemical binding]; other site 376619001796 Type III pantothenate kinase; Region: Pan_kinase; cl17198 376619001797 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 376619001798 tetramerization interface [polypeptide binding]; other site 376619001799 active site 376619001800 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 376619001801 pantoate--beta-alanine ligase; Region: panC; TIGR00018 376619001802 active site 376619001803 nucleotide binding site [chemical binding]; other site 376619001804 HIGH motif; other site 376619001805 KMSKS motif; other site 376619001806 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 376619001807 active site 376619001808 oligomerization interface [polypeptide binding]; other site 376619001809 metal binding site [ion binding]; metal-binding site 376619001810 Uncharacterized conserved protein [Function unknown]; Region: COG5495 376619001811 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 376619001812 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 376619001813 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 376619001814 nucleotide binding pocket [chemical binding]; other site 376619001815 K-X-D-G motif; other site 376619001816 catalytic site [active] 376619001817 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 376619001818 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 376619001819 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 376619001820 Dimer interface [polypeptide binding]; other site 376619001821 BRCT sequence motif; other site 376619001822 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 376619001823 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619001824 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619001825 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619001826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619001827 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 376619001828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 376619001829 dimer interface [polypeptide binding]; other site 376619001830 conserved gate region; other site 376619001831 putative PBP binding loops; other site 376619001832 ABC-ATPase subunit interface; other site 376619001833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 376619001834 dimer interface [polypeptide binding]; other site 376619001835 conserved gate region; other site 376619001836 putative PBP binding loops; other site 376619001837 ABC-ATPase subunit interface; other site 376619001838 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 376619001839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 376619001840 Walker A/P-loop; other site 376619001841 ATP binding site [chemical binding]; other site 376619001842 Q-loop/lid; other site 376619001843 ABC transporter signature motif; other site 376619001844 Walker B; other site 376619001845 D-loop; other site 376619001846 H-loop/switch region; other site 376619001847 TOBE domain; Region: TOBE_2; pfam08402 376619001848 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619001849 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619001850 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619001851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619001852 flavodoxin family protein, pseudogene 376619001853 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 376619001854 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 376619001855 homodimer interface [polypeptide binding]; other site 376619001856 NAD binding pocket [chemical binding]; other site 376619001857 ATP binding pocket [chemical binding]; other site 376619001858 Mg binding site [ion binding]; other site 376619001859 active-site loop [active] 376619001860 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 376619001861 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 376619001862 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 376619001863 HlyD family secretion protein; Region: HlyD_3; pfam13437 376619001864 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 376619001865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619001866 putative substrate translocation pore; other site 376619001867 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 376619001868 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 376619001869 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 376619001870 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 376619001871 acyl-activating enzyme (AAE) consensus motif; other site 376619001872 putative AMP binding site [chemical binding]; other site 376619001873 putative active site [active] 376619001874 putative CoA binding site [chemical binding]; other site 376619001875 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 376619001876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619001877 putative substrate translocation pore; other site 376619001878 POT family; Region: PTR2; cl17359 376619001879 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 376619001880 RNA methyltransferase, RsmE family; Region: TIGR00046 376619001881 Protein of unknown function (DUF445); Region: DUF445; pfam04286 376619001882 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 376619001883 mce related protein; Region: MCE; pfam02470 376619001884 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 376619001885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 376619001886 Walker A/P-loop; other site 376619001887 ATP binding site [chemical binding]; other site 376619001888 Q-loop/lid; other site 376619001889 ABC transporter signature motif; other site 376619001890 Walker B; other site 376619001891 D-loop; other site 376619001892 H-loop/switch region; other site 376619001893 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 376619001894 Permease; Region: Permease; pfam02405 376619001895 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 376619001896 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 376619001897 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 376619001898 RNA binding surface [nucleotide binding]; other site 376619001899 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 376619001900 active site 376619001901 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 376619001902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 376619001903 TPR motif; other site 376619001904 binding surface 376619001905 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 376619001906 FAD binding domain; Region: FAD_binding_4; pfam01565 376619001907 Berberine and berberine like; Region: BBE; pfam08031 376619001908 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 376619001909 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 376619001910 dimer interface [polypeptide binding]; other site 376619001911 active site 376619001912 glycine-pyridoxal phosphate binding site [chemical binding]; other site 376619001913 folate binding site [chemical binding]; other site 376619001914 hypothetical protein; Provisional; Region: PRK05255 376619001915 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 376619001916 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 376619001917 Ligand binding site; other site 376619001918 metal-binding site 376619001919 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 376619001920 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 376619001921 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 376619001922 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 376619001923 active site 376619001924 POT family; Region: PTR2; cl17359 376619001925 POT family; Region: PTR2; cl17359 376619001926 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 376619001927 Ligand Binding Site [chemical binding]; other site 376619001928 TilS substrate C-terminal domain; Region: TilS_C; smart00977 376619001929 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 376619001930 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 376619001931 ligand binding site [chemical binding]; other site 376619001932 NAD binding site [chemical binding]; other site 376619001933 tetramer interface [polypeptide binding]; other site 376619001934 catalytic site [active] 376619001935 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 376619001936 L-serine binding site [chemical binding]; other site 376619001937 ACT domain interface; other site 376619001938 thymidylate synthase; Reviewed; Region: thyA; PRK01827 376619001939 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 376619001940 dimerization interface [polypeptide binding]; other site 376619001941 active site 376619001942 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 376619001943 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 376619001944 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 376619001945 homodimer interface [polypeptide binding]; other site 376619001946 oligonucleotide binding site [chemical binding]; other site 376619001947 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 376619001948 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 376619001949 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 376619001950 catalytic residue [active] 376619001951 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 376619001952 Recombination protein O N terminal; Region: RecO_N; pfam11967 376619001953 Recombination protein O C terminal; Region: RecO_C; pfam02565 376619001954 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 376619001955 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 376619001956 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 376619001957 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 376619001958 BolA-like protein; Region: BolA; cl00386 376619001959 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 376619001960 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 376619001961 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 376619001962 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 376619001963 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 376619001964 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 376619001965 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 376619001966 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 376619001967 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 376619001968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 376619001969 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 376619001970 active site 376619001971 motif I; other site 376619001972 motif II; other site 376619001973 Soluble P-type ATPase [General function prediction only]; Region: COG4087 376619001974 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 376619001975 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 376619001976 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 376619001977 dimer interface [polypeptide binding]; other site 376619001978 active site 376619001979 metal binding site [ion binding]; metal-binding site 376619001980 glutathione binding site [chemical binding]; other site 376619001981 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619001982 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619001983 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619001984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619001985 metallopeptidase family M13 protein, pseudogene 376619001986 peptidase, M13 family 376619001987 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 376619001988 tetramer (dimer of dimers) interface [polypeptide binding]; other site 376619001989 active site 376619001990 dimer interface [polypeptide binding]; other site 376619001991 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 376619001992 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 376619001993 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 376619001994 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 376619001995 Transcriptional regulator [Transcription]; Region: LysR; COG0583 376619001996 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 376619001997 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 376619001998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 376619001999 NAD(P) binding site [chemical binding]; other site 376619002000 active site 376619002001 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 376619002002 active site 376619002003 catalytic site [active] 376619002004 substrate binding site [chemical binding]; other site 376619002005 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 376619002006 excinuclease ABC subunit B; Provisional; Region: PRK05298 376619002007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 376619002008 ATP binding site [chemical binding]; other site 376619002009 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 376619002010 nucleotide binding region [chemical binding]; other site 376619002011 ATP-binding site [chemical binding]; other site 376619002012 Ultra-violet resistance protein B; Region: UvrB; pfam12344 376619002013 UvrB/uvrC motif; Region: UVR; pfam02151 376619002014 Nuclease-related domain; Region: NERD; pfam08378 376619002015 glutamate racemase; Provisional; Region: PRK00865 376619002016 metabolite-proton symporter; Region: 2A0106; TIGR00883 376619002017 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619002018 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619002019 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619002020 conserved hypothetical protein, pseudogene 376619002021 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 376619002022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 376619002023 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 376619002024 putative dimer interface [polypeptide binding]; other site 376619002025 putative active site [active] 376619002026 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 376619002027 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 376619002028 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 376619002029 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 376619002030 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 376619002031 metal binding site [ion binding]; metal-binding site 376619002032 dimer interface [polypeptide binding]; other site 376619002033 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 376619002034 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 376619002035 generic binding surface II; other site 376619002036 generic binding surface I; other site 376619002037 major facilitator superfamily (MFS) transport protein, pseudogene 376619002038 putative transporter 376619002039 putative osmoprotectant transporter 376619002040 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 376619002041 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 376619002042 Ligand Binding Site [chemical binding]; other site 376619002043 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 376619002044 SmpB-tmRNA interface; other site 376619002045 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 376619002046 putative coenzyme Q binding site [chemical binding]; other site 376619002047 hypothetical protein; Validated; Region: PRK01777 376619002048 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 376619002049 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 376619002050 VacJ like lipoprotein; Region: VacJ; cl01073 376619002051 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 376619002052 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 376619002053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 376619002054 S-adenosylmethionine binding site [chemical binding]; other site 376619002055 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 376619002056 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 376619002057 G1 box; other site 376619002058 putative GEF interaction site [polypeptide binding]; other site 376619002059 GTP/Mg2+ binding site [chemical binding]; other site 376619002060 Switch I region; other site 376619002061 G2 box; other site 376619002062 G3 box; other site 376619002063 Switch II region; other site 376619002064 G4 box; other site 376619002065 G5 box; other site 376619002066 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 376619002067 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 376619002068 type I site-specific restriction-modification system, R (restriction) subunit 376619002069 Type I restriction enzyme subunit R 376619002070 type I restriction-modification system R subunit 376619002071 type I site-specific restriction-modification system, R (restriction) subunit 376619002072 hypothetical protein 376619002073 hypothetical protein 376619002074 type I restriction enzyme EcoEI specificity protein 376619002075 Type I restriction-modification enzyme, DNA specificity subunit S 376619002076 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 376619002077 DNA-binding site [nucleotide binding]; DNA binding site 376619002078 RNA-binding motif; other site 376619002079 DNA-methyltransferase, type I restriction-modification enzyme subunit M 376619002080 DNA-methyltransferase, type I restriction-modification enzyme subunit M 376619002081 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619002082 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619002083 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619002084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619002085 Sel1-like repeats; Region: SEL1; smart00671 376619002086 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 376619002087 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 376619002088 GTP/Mg2+ binding site [chemical binding]; other site 376619002089 G4 box; other site 376619002090 G5 box; other site 376619002091 G1 box; other site 376619002092 Switch I region; other site 376619002093 G2 box; other site 376619002094 G3 box; other site 376619002095 Switch II region; other site 376619002096 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 376619002097 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 376619002098 active site 376619002099 dimer interface [polypeptide binding]; other site 376619002100 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 376619002101 Glycoprotease family; Region: Peptidase_M22; pfam00814 376619002102 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 376619002103 putative active site [active] 376619002104 putative dimer interface [polypeptide binding]; other site 376619002105 aspartate aminotransferase; Provisional; Region: PRK05764 376619002106 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 376619002107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 376619002108 homodimer interface [polypeptide binding]; other site 376619002109 catalytic residue [active] 376619002110 GTPase Era; Reviewed; Region: era; PRK00089 376619002111 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 376619002112 G1 box; other site 376619002113 GTP/Mg2+ binding site [chemical binding]; other site 376619002114 Switch I region; other site 376619002115 G2 box; other site 376619002116 Switch II region; other site 376619002117 G3 box; other site 376619002118 G4 box; other site 376619002119 G5 box; other site 376619002120 FAD-binding family protein, pseudogene 376619002121 4Fe-4S ferredoxin, iron-sulfur binding protein 376619002122 D-lactate dehydrogenase, putative 376619002123 adenylate kinase; Reviewed; Region: adk; PRK00279 376619002124 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 376619002125 AMP-binding site [chemical binding]; other site 376619002126 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 376619002127 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 376619002128 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 376619002129 Pilus assembly protein, PilO; Region: PilO; cl01234 376619002130 Pilus assembly protein, PilP; Region: PilP; pfam04351 376619002131 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 376619002132 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 376619002133 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 376619002134 shikimate kinase; Reviewed; Region: aroK; PRK00131 376619002135 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 376619002136 ADP binding site [chemical binding]; other site 376619002137 magnesium binding site [ion binding]; other site 376619002138 putative shikimate binding site; other site 376619002139 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 376619002140 active site 376619002141 dimer interface [polypeptide binding]; other site 376619002142 metal binding site [ion binding]; metal-binding site 376619002143 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 376619002144 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 376619002145 Proline dehydrogenase; Region: Pro_dh; pfam01619 376619002146 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 376619002147 Glutamate binding site [chemical binding]; other site 376619002148 NAD binding site [chemical binding]; other site 376619002149 catalytic residues [active] 376619002150 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 376619002151 NAD(P) binding site [chemical binding]; other site 376619002152 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 376619002153 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 376619002154 benzoate transport; Region: 2A0115; TIGR00895 376619002155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619002156 putative substrate translocation pore; other site 376619002157 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 376619002158 Flavoprotein; Region: Flavoprotein; pfam02441 376619002159 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 376619002160 Aldose 1-epimerase (pseudogene) 376619002161 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 376619002162 dehydrogenase 376619002163 oxidoreductase 376619002164 Short-chain dehydrogenase/reductase (SDR) family protein, pseudogene 376619002165 PRC-barrel domain; Region: PRC; pfam05239 376619002166 PRC-barrel domain; Region: PRC; pfam05239 376619002167 deoxyribodipyrimidine photolyase, pseudogene 376619002168 blue-light photoreceptor 376619002169 deoxyribodipyrimidine photolyase 376619002170 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619002171 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619002172 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619002173 ferrochelatase; Reviewed; Region: hemH; PRK00035 376619002174 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 376619002175 C-terminal domain interface [polypeptide binding]; other site 376619002176 active site 376619002177 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 376619002178 active site 376619002179 N-terminal domain interface [polypeptide binding]; other site 376619002180 Predicted membrane protein [Function unknown]; Region: COG1511 376619002181 conserved hypothetical protein, pseudogene 376619002182 conserved hypothetical protein 376619002183 conserved hypothetical protein 376619002184 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 376619002185 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 376619002186 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 376619002187 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 376619002188 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 376619002189 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 376619002190 Walker A motif; other site 376619002191 ATP binding site [chemical binding]; other site 376619002192 Walker B motif; other site 376619002193 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 376619002194 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 376619002195 active site 376619002196 catalytic site [active] 376619002197 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 376619002198 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 376619002199 putative MPT binding site; other site 376619002200 cyanophycin synthetase; Provisional; Region: PRK14016 376619002201 ATP-grasp domain; Region: ATP-grasp_4; cl17255 376619002202 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 376619002203 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 376619002204 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 376619002205 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 376619002206 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 376619002207 homotrimer interaction site [polypeptide binding]; other site 376619002208 zinc binding site [ion binding]; other site 376619002209 CDP-binding sites; other site 376619002210 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 376619002211 active site residue [active] 376619002212 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 376619002213 active site residue [active] 376619002214 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 376619002215 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 376619002216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 376619002217 dimer interface [polypeptide binding]; other site 376619002218 conserved gate region; other site 376619002219 putative PBP binding loops; other site 376619002220 ABC-ATPase subunit interface; other site 376619002221 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 376619002222 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 376619002223 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 376619002224 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 376619002225 Walker A/P-loop; other site 376619002226 ATP binding site [chemical binding]; other site 376619002227 Q-loop/lid; other site 376619002228 ABC transporter signature motif; other site 376619002229 Walker B; other site 376619002230 D-loop; other site 376619002231 H-loop/switch region; other site 376619002232 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 376619002233 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 376619002234 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 376619002235 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 376619002236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 376619002237 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 376619002238 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 376619002239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 376619002240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 376619002241 dimerization interface [polypeptide binding]; other site 376619002242 Isochorismatase family; Region: Isochorismatase; pfam00857 376619002243 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 376619002244 catalytic triad [active] 376619002245 conserved cis-peptide bond; other site 376619002246 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 376619002247 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 376619002248 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 376619002249 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 376619002250 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 376619002251 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 376619002252 Protein export membrane protein; Region: SecD_SecF; pfam02355 376619002253 Src Homology 3 domain superfamily; Region: SH3; cl17036 376619002254 peptide ligand binding site [polypeptide binding]; other site 376619002255 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 376619002256 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 376619002257 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 376619002258 DNA binding residues [nucleotide binding] 376619002259 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 376619002260 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 376619002261 hinge; other site 376619002262 active site 376619002263 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 376619002264 RNA/DNA hybrid binding site [nucleotide binding]; other site 376619002265 active site 376619002266 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 376619002267 active site 376619002268 homodimer interface [polypeptide binding]; other site 376619002269 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 376619002270 active site clefts [active] 376619002271 zinc binding site [ion binding]; other site 376619002272 dimer interface [polypeptide binding]; other site 376619002273 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 376619002274 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 376619002275 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 376619002276 catalytic residue [active] 376619002277 Rubredoxin [Energy production and conversion]; Region: COG1773 376619002278 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 376619002279 iron binding site [ion binding]; other site 376619002280 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619002281 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619002282 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619002283 Uncharacterized conserved protein [Function unknown]; Region: COG0397 376619002284 hypothetical protein; Validated; Region: PRK00029 376619002285 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 376619002286 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 376619002287 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 376619002288 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 376619002289 dimer interface [polypeptide binding]; other site 376619002290 active site 376619002291 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 376619002292 dimer interface [polypeptide binding]; other site 376619002293 active site 376619002294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619002295 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 376619002296 putative substrate translocation pore; other site 376619002297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619002298 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 376619002299 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 376619002300 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619002301 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619002302 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619002303 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 376619002304 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 376619002305 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 376619002306 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 376619002307 conserved hypothetical protein, pseudogene 376619002308 conserved hypothetical protein 376619002309 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 376619002310 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 376619002311 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 376619002312 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 376619002313 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 376619002314 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 376619002315 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 376619002316 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 376619002317 active site 376619002318 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 376619002319 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 376619002320 active site 376619002321 substrate binding site [chemical binding]; other site 376619002322 Mg2+ binding site [ion binding]; other site 376619002323 beta-lactamase TEM; Provisional; Region: PRK15442 376619002324 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 376619002325 VirK protein; Region: VirK; pfam06903 376619002326 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 376619002327 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 376619002328 putative active site [active] 376619002329 catalytic triad [active] 376619002330 putative dimer interface [polypeptide binding]; other site 376619002331 FOG: CBS domain [General function prediction only]; Region: COG0517 376619002332 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 376619002333 Transporter associated domain; Region: CorC_HlyC; smart01091 376619002334 metal-binding heat shock protein; Provisional; Region: PRK00016 376619002335 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 376619002336 PhoH-like protein; Region: PhoH; pfam02562 376619002337 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 376619002338 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 376619002339 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 376619002340 FeS/SAM binding site; other site 376619002341 TRAM domain; Region: TRAM; pfam01938 376619002342 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 376619002343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 376619002344 HAD superfamily protein 376619002345 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 376619002346 thymidine kinase; Provisional; Region: PRK04296 376619002347 trigger factor; Provisional; Region: tig; PRK01490 376619002348 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 376619002349 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 376619002350 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 376619002351 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 376619002352 oligomer interface [polypeptide binding]; other site 376619002353 active site residues [active] 376619002354 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 376619002355 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 376619002356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 376619002357 Walker A motif; other site 376619002358 ATP binding site [chemical binding]; other site 376619002359 Walker B motif; other site 376619002360 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 376619002361 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 376619002362 Found in ATP-dependent protease La (LON); Region: LON; smart00464 376619002363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 376619002364 Walker A motif; other site 376619002365 ATP binding site [chemical binding]; other site 376619002366 Walker B motif; other site 376619002367 arginine finger; other site 376619002368 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 376619002369 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 376619002370 IHF dimer interface [polypeptide binding]; other site 376619002371 IHF - DNA interface [nucleotide binding]; other site 376619002372 SurA N-terminal domain; Region: SurA_N_3; cl07813 376619002373 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 376619002374 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 376619002375 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 376619002376 bacterial Hfq-like; Region: Hfq; cd01716 376619002377 hexamer interface [polypeptide binding]; other site 376619002378 Sm1 motif; other site 376619002379 RNA binding site [nucleotide binding]; other site 376619002380 Sm2 motif; other site 376619002381 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 376619002382 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 376619002383 HflX GTPase family; Region: HflX; cd01878 376619002384 G1 box; other site 376619002385 GTP/Mg2+ binding site [chemical binding]; other site 376619002386 Switch I region; other site 376619002387 G2 box; other site 376619002388 G3 box; other site 376619002389 Switch II region; other site 376619002390 G4 box; other site 376619002391 G5 box; other site 376619002392 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 376619002393 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 376619002394 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 376619002395 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 376619002396 HflK protein; Region: hflK; TIGR01933 376619002397 FtsH protease regulator HflC; Provisional; Region: PRK11029 376619002398 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 376619002399 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 376619002400 Low molecular weight phosphatase family; Region: LMWPc; cd00115 376619002401 active site 376619002402 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 376619002403 G1 box; other site 376619002404 GTP/Mg2+ binding site [chemical binding]; other site 376619002405 Switch I region; other site 376619002406 G2 box; other site 376619002407 G3 box; other site 376619002408 Switch II region; other site 376619002409 G4 box; other site 376619002410 G5 box; other site 376619002411 hypothetical protein 376619002412 threonine synthase, pseudogene 376619002413 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 376619002414 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 376619002415 dihydroxy-acid dehydratase 376619002416 Dihydroxy-acid dehydratase 376619002417 acetolactate synthase, large subunit (pseudogene) 376619002418 acetolactate synthase. 376619002419 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 376619002420 putative valine binding site [chemical binding]; other site 376619002421 dimer interface [polypeptide binding]; other site 376619002422 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 376619002423 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 376619002424 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 376619002425 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 376619002426 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 376619002427 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 376619002428 ATP binding site [chemical binding]; other site 376619002429 putative Mg++ binding site [ion binding]; other site 376619002430 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 376619002431 nucleotide binding region [chemical binding]; other site 376619002432 ATP-binding site [chemical binding]; other site 376619002433 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 376619002434 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 376619002435 YccA-like proteins; Region: YccA_like; cd10433 376619002436 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 376619002437 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 376619002438 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 376619002439 minor groove reading motif; other site 376619002440 helix-hairpin-helix signature motif; other site 376619002441 substrate binding pocket [chemical binding]; other site 376619002442 active site 376619002443 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 376619002444 ferredoxin; Provisional; Region: PRK08764 376619002445 Putative Fe-S cluster; Region: FeS; cl17515 376619002446 4Fe-4S binding domain; Region: Fer4; pfam00037 376619002447 glutaredoxin 2; Provisional; Region: PRK10387 376619002448 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 376619002449 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 376619002450 N-terminal domain interface [polypeptide binding]; other site 376619002451 POT family; Region: PTR2; cl17359 376619002452 POT family; Region: PTR2; cl17359 376619002453 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 376619002454 Ferritin-like domain; Region: Ferritin; pfam00210 376619002455 ferroxidase diiron center [ion binding]; other site 376619002456 lipoyl synthase; Provisional; Region: PRK05481 376619002457 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 376619002458 FeS/SAM binding site; other site 376619002459 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 376619002460 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 376619002461 conserved cys residue [active] 376619002462 hypothetical protein; Validated; Region: PRK00110 376619002463 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 376619002464 active site 376619002465 putative DNA-binding cleft [nucleotide binding]; other site 376619002466 dimer interface [polypeptide binding]; other site 376619002467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619002468 putative substrate translocation pore; other site 376619002469 D-galactonate transporter; Region: 2A0114; TIGR00893 376619002470 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 376619002471 RuvA N terminal domain; Region: RuvA_N; pfam01330 376619002472 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 376619002473 RmuC family; Region: RmuC; pfam02646 376619002474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 376619002475 dimerization interface [polypeptide binding]; other site 376619002476 putative Zn2+ binding site [ion binding]; other site 376619002477 putative DNA binding site [nucleotide binding]; other site 376619002478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 376619002479 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 376619002480 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 376619002481 histidine decarboxylase; Provisional; Region: PRK02769 376619002482 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 376619002483 catalytic residue [active] 376619002484 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 376619002485 intersubunit interface [polypeptide binding]; other site 376619002486 active site 376619002487 Zn2+ binding site [ion binding]; other site 376619002488 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 376619002489 active site 376619002490 DNA binding site [nucleotide binding] 376619002491 Isochorismatase family; Region: Isochorismatase; pfam00857 376619002492 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 376619002493 catalytic triad [active] 376619002494 conserved cis-peptide bond; other site 376619002495 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 376619002496 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 376619002497 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 376619002498 hypothetical protein 376619002499 Mechanosensitive ion channel; Region: MS_channel; pfam00924 376619002500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619002501 putative substrate translocation pore; other site 376619002502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 376619002503 major facilitator superfamily (MFS) transport protein, pseudogene 376619002504 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 376619002505 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 376619002506 putative active site [active] 376619002507 Zn binding site [ion binding]; other site 376619002508 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 376619002509 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 376619002510 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 376619002511 active site 376619002512 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 376619002513 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 376619002514 5S rRNA interface [nucleotide binding]; other site 376619002515 CTC domain interface [polypeptide binding]; other site 376619002516 L16 interface [polypeptide binding]; other site 376619002517 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 376619002518 Domain of unknown function DUF21; Region: DUF21; pfam01595 376619002519 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 376619002520 Transporter associated domain; Region: CorC_HlyC; pfam03471 376619002521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 376619002522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 376619002523 Methyltransferase domain; Region: Methyltransf_31; pfam13847 376619002524 S-adenosylmethionine binding site [chemical binding]; other site 376619002525 GTP-binding protein YchF; Reviewed; Region: PRK09601 376619002526 YchF GTPase; Region: YchF; cd01900 376619002527 G1 box; other site 376619002528 GTP/Mg2+ binding site [chemical binding]; other site 376619002529 Switch I region; other site 376619002530 G2 box; other site 376619002531 Switch II region; other site 376619002532 G3 box; other site 376619002533 G4 box; other site 376619002534 G5 box; other site 376619002535 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 376619002536 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 376619002537 putative active site [active] 376619002538 catalytic residue [active] 376619002539 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 376619002540 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 376619002541 dimerization domain [polypeptide binding]; other site 376619002542 dimer interface [polypeptide binding]; other site 376619002543 catalytic residues [active] 376619002544 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 376619002545 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 376619002546 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 376619002547 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 376619002548 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 376619002549 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 376619002550 Ion channel; Region: Ion_trans_2; pfam07885 376619002551 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 376619002552 POT family; Region: PTR2; cl17359 376619002553 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 376619002554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 376619002555 Walker A motif; other site 376619002556 ATP binding site [chemical binding]; other site 376619002557 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 376619002558 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 376619002559 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 376619002560 active site 376619002561 HslU subunit interaction site [polypeptide binding]; other site 376619002562 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 376619002563 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 376619002564 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 376619002565 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 376619002566 active site 376619002567 HIGH motif; other site 376619002568 dimer interface [polypeptide binding]; other site 376619002569 KMSKS motif; other site 376619002570 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 376619002571 RNA binding surface [nucleotide binding]; other site 376619002572 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619002573 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619002574 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619002575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619002576 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 376619002577 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 376619002578 phosphate binding site [ion binding]; other site 376619002579 FAD binding domain; Region: FAD_binding_4; pfam01565 376619002580 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 376619002581 Oxidoreductase, pseudogene 376619002582 Iron-containing alcohol dehydrogenase,pseudogene 376619002583 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 376619002584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 376619002585 S-adenosylmethionine binding site [chemical binding]; other site 376619002586 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 376619002587 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 376619002588 FMN binding site [chemical binding]; other site 376619002589 active site 376619002590 catalytic residues [active] 376619002591 substrate binding site [chemical binding]; other site 376619002592 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 376619002593 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 376619002594 Methyltransferase domain; Region: Methyltransf_26; pfam13659 376619002595 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 376619002596 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 376619002597 putative active site [active] 376619002598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 376619002599 Walker A/P-loop; other site 376619002600 ATP binding site [chemical binding]; other site 376619002601 AAA domain; Region: AAA_21; pfam13304 376619002602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 376619002603 ABC transporter signature motif; other site 376619002604 Walker B; other site 376619002605 D-loop; other site 376619002606 H-loop/switch region; other site 376619002607 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 376619002608 active site 376619002609 DNA polymerase IV; Validated; Region: PRK02406 376619002610 DNA binding site [nucleotide binding] 376619002611 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 376619002612 DJ-1 family protein; Region: not_thiJ; TIGR01383 376619002613 conserved cys residue [active] 376619002614 ABC transporter, ATP-binding protein,pseudogene 376619002615 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 376619002616 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 376619002617 GSH binding site [chemical binding]; other site 376619002618 catalytic residues [active] 376619002619 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 376619002620 dimer interface [polypeptide binding]; other site 376619002621 putative radical transfer pathway; other site 376619002622 diiron center [ion binding]; other site 376619002623 tyrosyl radical; other site 376619002624 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 376619002625 GSH binding site [chemical binding]; other site 376619002626 catalytic residues [active] 376619002627 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 376619002628 Class I ribonucleotide reductase; Region: RNR_I; cd01679 376619002629 active site 376619002630 dimer interface [polypeptide binding]; other site 376619002631 catalytic residues [active] 376619002632 effector binding site; other site 376619002633 R2 peptide binding site; other site 376619002634 malate dehydrogenase; Reviewed; Region: PRK06223 376619002635 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 376619002636 NAD(P) binding site [chemical binding]; other site 376619002637 dimer interface [polypeptide binding]; other site 376619002638 tetramer (dimer of dimers) interface [polypeptide binding]; other site 376619002639 substrate binding site [chemical binding]; other site 376619002640 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 376619002641 diiron binding motif [ion binding]; other site 376619002642 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 376619002643 N-acetyl-D-glucosamine binding site [chemical binding]; other site 376619002644 catalytic residue [active] 376619002645 ThiF family protein, pseudogene 376619002646 Transposase; ribosomal slippage 376619002647 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 376619002648 ATP binding site [chemical binding]; other site 376619002649 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 376619002650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 376619002651 motif II; other site 376619002652 peroxidase; Provisional; Region: PRK15000 376619002653 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 376619002654 dimer interface [polypeptide binding]; other site 376619002655 decamer (pentamer of dimers) interface [polypeptide binding]; other site 376619002656 catalytic triad [active] 376619002657 peroxidatic and resolving cysteines [active] 376619002658 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 376619002659 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 376619002660 PhnA protein; Region: PhnA; pfam03831 376619002661 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 376619002662 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 376619002663 active site 376619002664 catalytic site [active] 376619002665 substrate binding site [chemical binding]; other site 376619002666 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 376619002667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 376619002668 conserved hypothetical protein, pseudogene 376619002669 hypothetical protein 376619002670 hypothetical protein 376619002671 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 376619002672 conserved hypothetical protein 376619002673 conserved hypothetical protein 376619002674 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 376619002675 putative homodimer interface [polypeptide binding]; other site 376619002676 putative homotetramer interface [polypeptide binding]; other site 376619002677 putative allosteric switch controlling residues; other site 376619002678 putative metal binding site [ion binding]; other site 376619002679 putative homodimer-homodimer interface [polypeptide binding]; other site 376619002680 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 376619002681 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 376619002682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 376619002683 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 376619002684 dimerization interface [polypeptide binding]; other site 376619002685 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 376619002686 catalytic triad [active] 376619002687 dimer interface [polypeptide binding]; other site 376619002688 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 376619002689 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 376619002690 putative NAD(P) binding site [chemical binding]; other site 376619002691 homodimer interface [polypeptide binding]; other site 376619002692 cytidylate kinase; Provisional; Region: cmk; PRK00023 376619002693 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 376619002694 CMP-binding site; other site 376619002695 The sites determining sugar specificity; other site 376619002696 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 376619002697 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 376619002698 catalytic residue [active] 376619002699 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619002700 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619002701 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619002702 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619002703 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 376619002704 catalytic core [active] 376619002705 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 376619002706 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 376619002707 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619002708 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619002709 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619002710 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 376619002711 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 376619002712 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 376619002713 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 376619002714 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 376619002715 replicative DNA helicase; Region: DnaB; TIGR00665 376619002716 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 376619002717 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 376619002718 Walker A motif; other site 376619002719 ATP binding site [chemical binding]; other site 376619002720 Walker B motif; other site 376619002721 DNA binding loops [nucleotide binding] 376619002722 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 376619002723 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 376619002724 FeS/SAM binding site; other site 376619002725 Tetratricopeptide repeat; Region: TPR_12; pfam13424 376619002726 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 376619002727 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 376619002728 RNA binding surface [nucleotide binding]; other site 376619002729 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 376619002730 probable active site [active] 376619002731 preprotein translocase subunit SecA; Validated; Region: secA; CHL00122 376619002732 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 376619002733 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 376619002734 Coenzyme A binding pocket [chemical binding]; other site 376619002735 Transposase, pseudogene 376619002736 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 376619002737 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 376619002738 CysD dimerization site [polypeptide binding]; other site 376619002739 G1 box; other site 376619002740 putative GEF interaction site [polypeptide binding]; other site 376619002741 GTP/Mg2+ binding site [chemical binding]; other site 376619002742 Switch I region; other site 376619002743 G2 box; other site 376619002744 G3 box; other site 376619002745 Switch II region; other site 376619002746 G4 box; other site 376619002747 G5 box; other site 376619002748 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 376619002749 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 376619002750 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 376619002751 ligand-binding site [chemical binding]; other site 376619002752 PQ loop repeat; Region: PQ-loop; pfam04193 376619002753 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 376619002754 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 376619002755 substrate binding pocket [chemical binding]; other site 376619002756 chain length determination region; other site 376619002757 substrate-Mg2+ binding site; other site 376619002758 catalytic residues [active] 376619002759 aspartate-rich region 1; other site 376619002760 active site lid residues [active] 376619002761 aspartate-rich region 2; other site 376619002762 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 376619002763 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 376619002764 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 376619002765 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 376619002766 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 376619002767 Ligand Binding Site [chemical binding]; other site 376619002768 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 376619002769 active site 376619002770 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 376619002771 N-acetyl-D-glucosamine binding site [chemical binding]; other site 376619002772 catalytic residue [active] 376619002773 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 376619002774 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 376619002775 Yqey-like protein; Region: YqeY; pfam09424 376619002776 CHC2 zinc finger; Region: zf-CHC2; pfam01807 376619002777 DNA primase; Validated; Region: dnaG; PRK05667 376619002778 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 376619002779 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 376619002780 active site 376619002781 metal binding site [ion binding]; metal-binding site 376619002782 interdomain interaction site; other site 376619002783 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 376619002784 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 376619002785 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 376619002786 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 376619002787 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 376619002788 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 376619002789 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 376619002790 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 376619002791 DNA binding residues [nucleotide binding] 376619002792 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 376619002793 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 376619002794 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 376619002795 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 376619002796 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 376619002797 catalytic site [active] 376619002798 glycosyl hydrolases family 31 protein,pseudogene 376619002799 putative oligogalacturonide transporter 376619002800 conserved hypothetical membrane protein,pseudogene 376619002801 lipoate-protein ligase B; Provisional; Region: PRK14342 376619002802 Protein of unknown function (DUF493); Region: DUF493; pfam04359 376619002803 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 376619002804 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 376619002805 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 376619002806 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 376619002807 dimer interface [polypeptide binding]; other site 376619002808 substrate binding site [chemical binding]; other site 376619002809 metal binding sites [ion binding]; metal-binding site 376619002810 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 376619002811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 376619002812 active site 376619002813 motif I; other site 376619002814 motif II; other site 376619002815 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 376619002816 OstA-like protein; Region: OstA; cl00844 376619002817 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 376619002818 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 376619002819 Walker A/P-loop; other site 376619002820 ATP binding site [chemical binding]; other site 376619002821 Q-loop/lid; other site 376619002822 ABC transporter signature motif; other site 376619002823 Walker B; other site 376619002824 D-loop; other site 376619002825 H-loop/switch region; other site 376619002826 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 376619002827 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 376619002828 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 376619002829 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 376619002830 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 376619002831 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 376619002832 dimerization interface 3.5A [polypeptide binding]; other site 376619002833 active site 376619002834 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 376619002835 GMP synthase; Reviewed; Region: guaA; PRK00074 376619002836 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 376619002837 AMP/PPi binding site [chemical binding]; other site 376619002838 candidate oxyanion hole; other site 376619002839 catalytic triad [active] 376619002840 potential glutamine specificity residues [chemical binding]; other site 376619002841 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 376619002842 ATP Binding subdomain [chemical binding]; other site 376619002843 Ligand Binding sites [chemical binding]; other site 376619002844 Dimerization subdomain; other site 376619002845 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 376619002846 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 376619002847 TPP-binding site; other site 376619002848 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 376619002849 PYR/PP interface [polypeptide binding]; other site 376619002850 dimer interface [polypeptide binding]; other site 376619002851 TPP binding site [chemical binding]; other site 376619002852 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 376619002853 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 376619002854 putative active site pocket [active] 376619002855 dimerization interface [polypeptide binding]; other site 376619002856 putative catalytic residue [active] 376619002857 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 376619002858 active site 376619002859 catalytic triad [active] 376619002860 oxyanion hole [active] 376619002861 switch loop; other site 376619002862 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 376619002863 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 376619002864 classical (c) SDRs; Region: SDR_c; cd05233 376619002865 NAD(P) binding site [chemical binding]; other site 376619002866 active site 376619002867 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 376619002868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 376619002869 Walker A motif; other site 376619002870 ATP binding site [chemical binding]; other site 376619002871 Walker B motif; other site 376619002872 arginine finger; other site 376619002873 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 376619002874 conserved hypothetical protein, pseudogene 376619002875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 376619002876 non-specific DNA binding site [nucleotide binding]; other site 376619002877 salt bridge; other site 376619002878 sequence-specific DNA binding site [nucleotide binding]; other site 376619002879 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 376619002880 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 376619002881 MFS/sugar transport protein; Region: MFS_2; pfam13347 376619002882 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 376619002883 POT family; Region: PTR2; cl17359 376619002884 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619002885 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619002886 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619002887 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 376619002888 active site 376619002889 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 376619002890 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 376619002891 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 376619002892 high-affinity choline transport protein 376619002893 Betaine/carnitine/choline transporter (BCCT) family protein, pseudogene 376619002894 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 376619002895 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 376619002896 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 376619002897 major facilitator superfamily (MFS) transport protein, pseudogene 376619002898 bicyclomycin resistance protein 376619002899 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 376619002900 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 376619002901 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 376619002902 catalytic residues [active] 376619002903 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 376619002904 4Fe-4S ferredoxin (electron transport) family protein, pseudogene 376619002905 conserved hypothetical protein 376619002906 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 376619002907 hypothetical protein 376619002908 Superfamily I helicase 376619002909 UvrD/REP helicase family protein, pseudogene 376619002910 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 376619002911 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 376619002912 motif 1; other site 376619002913 active site 376619002914 motif 2; other site 376619002915 motif 3; other site 376619002916 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 376619002917 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 376619002918 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 376619002919 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 376619002920 interface (dimer of trimers) [polypeptide binding]; other site 376619002921 Substrate-binding/catalytic site; other site 376619002922 Zn-binding sites [ion binding]; other site 376619002923 transaldolase-like protein; Provisional; Region: PTZ00411 376619002924 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 376619002925 active site 376619002926 dimer interface [polypeptide binding]; other site 376619002927 catalytic residue [active] 376619002928 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 376619002929 catalytic triad [active] 376619002930 conserved cis-peptide bond; other site 376619002931 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619002932 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619002933 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619002934 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 376619002935 Isochorismatase family; Region: Isochorismatase; pfam00857 376619002936 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 376619002937 catalytic triad [active] 376619002938 conserved cis-peptide bond; other site 376619002939 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 376619002940 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 376619002941 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 376619002942 Part of AAA domain; Region: AAA_19; pfam13245 376619002943 Family description; Region: UvrD_C_2; pfam13538 376619002944 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 376619002945 S1 domain; Region: S1_2; pfam13509 376619002946 S1 domain; Region: S1_2; pfam13509 376619002947 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 376619002948 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 376619002949 active site residue [active] 376619002950 recombination associated protein; Reviewed; Region: rdgC; PRK00321 376619002951 HipA N-terminal domain; Region: couple_hipA; TIGR03071 376619002952 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 376619002953 HipA-like N-terminal domain; Region: HipA_N; pfam07805 376619002954 HipA-like C-terminal domain; Region: HipA_C; pfam07804 376619002955 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 376619002956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 376619002957 non-specific DNA binding site [nucleotide binding]; other site 376619002958 salt bridge; other site 376619002959 sequence-specific DNA binding site [nucleotide binding]; other site 376619002960 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619002961 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619002962 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619002963 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619002964 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 376619002965 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 376619002966 NusB family; Region: NusB; pfam01029 376619002967 putative RNA binding site [nucleotide binding]; other site 376619002968 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 376619002969 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 376619002970 active site 376619002971 dimerization interface [polypeptide binding]; other site 376619002972 Predicted membrane protein [Function unknown]; Region: COG2855 376619002973 putative transporter; Provisional; Region: PRK03699 376619002974 conserved hypothetical protein, pseudogene 376619002975 YCII-related domain; Region: YCII; cl00999 376619002976 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 376619002977 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 376619002978 dimer interface [polypeptide binding]; other site 376619002979 active site 376619002980 acyl carrier protein; Provisional; Region: acpP; PRK00982 376619002981 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 376619002982 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 376619002983 NAD(P) binding site [chemical binding]; other site 376619002984 homotetramer interface [polypeptide binding]; other site 376619002985 homodimer interface [polypeptide binding]; other site 376619002986 active site 376619002987 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 376619002988 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 376619002989 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 376619002990 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 376619002991 dimer interface [polypeptide binding]; other site 376619002992 active site 376619002993 CoA binding pocket [chemical binding]; other site 376619002994 putative phosphate acyltransferase; Provisional; Region: PRK05331 376619002995 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 376619002996 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 376619002997 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 376619002998 TPP-binding site [chemical binding]; other site 376619002999 dimer interface [polypeptide binding]; other site 376619003000 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 376619003001 PYR/PP interface [polypeptide binding]; other site 376619003002 dimer interface [polypeptide binding]; other site 376619003003 TPP binding site [chemical binding]; other site 376619003004 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 376619003005 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 376619003006 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 376619003007 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 376619003008 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 376619003009 Phosphoglycerate kinase; Region: PGK; pfam00162 376619003010 substrate binding site [chemical binding]; other site 376619003011 hinge regions; other site 376619003012 ADP binding site [chemical binding]; other site 376619003013 catalytic site [active] 376619003014 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 376619003015 pyruvate kinase; Provisional; Region: PRK05826 376619003016 domain interfaces; other site 376619003017 active site 376619003018 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 376619003019 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 376619003020 intersubunit interface [polypeptide binding]; other site 376619003021 active site 376619003022 zinc binding site [ion binding]; other site 376619003023 Na+ binding site [ion binding]; other site 376619003024 Trehalase; Region: Trehalase; cl17346 376619003025 Trehalase; Region: Trehalase; cl17346 376619003026 major facilitator family transporter 376619003027 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619003028 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619003029 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619003030 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619003031 major facilitator superfamily (MFS) transport protein, pseudogene 376619003032 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 376619003033 Protein of unknown function (DUF877); Region: DUF877; pfam05943 376619003034 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 376619003035 Intracellular growth locus C protein; Region: IglC; pfam11550 376619003036 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 376619003037 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 376619003038 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 376619003039 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 376619003040 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 376619003041 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 376619003042 dimer interface [polypeptide binding]; other site 376619003043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 376619003044 catalytic residue [active] 376619003045 choloylglycine hydrolase family protein,pseudogene 376619003046 Transcriptional regulator [Transcription]; Region: LysR; COG0583 376619003047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 376619003048 putative DNA binding site [nucleotide binding]; other site 376619003049 putative Zn2+ binding site [ion binding]; other site 376619003050 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 376619003051 dimerization interface [polypeptide binding]; other site 376619003052 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 376619003053 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 376619003054 trmE is a tRNA modification GTPase; Region: trmE; cd04164 376619003055 G1 box; other site 376619003056 GTP/Mg2+ binding site [chemical binding]; other site 376619003057 Switch I region; other site 376619003058 G2 box; other site 376619003059 Switch II region; other site 376619003060 G3 box; other site 376619003061 G4 box; other site 376619003062 G5 box; other site 376619003063 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 376619003064 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 376619003065 30S subunit binding site; other site 376619003066 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 376619003067 active site 376619003068 phosphorylation site [posttranslational modification] 376619003069 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 376619003070 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 376619003071 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 376619003072 RNA/DNA hybrid binding site [nucleotide binding]; other site 376619003073 active site 376619003074 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 376619003075 Na binding site [ion binding]; other site 376619003076 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 376619003077 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 376619003078 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 376619003079 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 376619003080 23S rRNA interface [nucleotide binding]; other site 376619003081 L3 interface [polypeptide binding]; other site 376619003082 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 376619003083 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 376619003084 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 376619003085 MltA specific insert domain; Region: MltA; smart00925 376619003086 3D domain; Region: 3D; pfam06725 376619003087 GrpE; Region: GrpE; pfam01025 376619003088 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 376619003089 dimer interface [polypeptide binding]; other site 376619003090 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 376619003091 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 376619003092 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 376619003093 nucleotide binding site [chemical binding]; other site 376619003094 chaperone protein DnaJ; Provisional; Region: PRK10767 376619003095 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 376619003096 HSP70 interaction site [polypeptide binding]; other site 376619003097 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 376619003098 substrate binding site [polypeptide binding]; other site 376619003099 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 376619003100 Zn binding sites [ion binding]; other site 376619003101 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 376619003102 dimer interface [polypeptide binding]; other site 376619003103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 376619003104 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 376619003105 putative effector binding pocket; other site 376619003106 dimerization interface [polypeptide binding]; other site 376619003107 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619003108 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619003109 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619003110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619003111 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 376619003112 EamA-like transporter family; Region: EamA; pfam00892 376619003113 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 376619003114 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 376619003115 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 376619003116 dimer interface [polypeptide binding]; other site 376619003117 motif 1; other site 376619003118 active site 376619003119 motif 2; other site 376619003120 motif 3; other site 376619003121 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 376619003122 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 376619003123 putative tRNA-binding site [nucleotide binding]; other site 376619003124 B3/4 domain; Region: B3_4; pfam03483 376619003125 tRNA synthetase B5 domain; Region: B5; smart00874 376619003126 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 376619003127 dimer interface [polypeptide binding]; other site 376619003128 motif 1; other site 376619003129 motif 3; other site 376619003130 motif 2; other site 376619003131 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 376619003132 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 376619003133 metal binding site 2 [ion binding]; metal-binding site 376619003134 putative DNA binding helix; other site 376619003135 metal binding site 1 [ion binding]; metal-binding site 376619003136 dimer interface [polypeptide binding]; other site 376619003137 structural Zn2+ binding site [ion binding]; other site 376619003138 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 376619003139 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 376619003140 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 376619003141 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 376619003142 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 376619003143 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 376619003144 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 376619003145 putative active site [active] 376619003146 catalytic site [active] 376619003147 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 376619003148 putative active site [active] 376619003149 catalytic site [active] 376619003150 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 376619003151 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 376619003152 putative active site [active] 376619003153 catalytic site [active] 376619003154 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 376619003155 putative active site [active] 376619003156 catalytic site [active] 376619003157 metabolite-proton symporter; Region: 2A0106; TIGR00883 376619003158 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 376619003159 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 376619003160 Walker A motif; other site 376619003161 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 376619003162 trimer interface [polypeptide binding]; other site 376619003163 active site 376619003164 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 376619003165 Mechanosensitive ion channel; Region: MS_channel; pfam00924 376619003166 Lipopolysaccharide-assembly; Region: LptE; cl01125 376619003167 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 376619003168 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 376619003169 HIGH motif; other site 376619003170 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 376619003171 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 376619003172 active site 376619003173 KMSKS motif; other site 376619003174 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 376619003175 tRNA binding surface [nucleotide binding]; other site 376619003176 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 376619003177 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 376619003178 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 376619003179 Transglutaminase/protease-like homologues; Region: TGc; smart00460 376619003180 Sel1 repeat; Region: Sel1; cl02723 376619003181 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 376619003182 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 376619003183 PAS fold; Region: PAS_4; pfam08448 376619003184 hypothetical protein; Provisional; Region: PRK07505 376619003185 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 376619003186 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 376619003187 catalytic residue [active] 376619003188 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 376619003189 Transcriptional regulators [Transcription]; Region: MarR; COG1846 376619003190 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 376619003191 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 376619003192 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 376619003193 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 376619003194 catalytic residues [active] 376619003195 amidinotransferase family protein, pseudogene 376619003196 unnamed protein product; some similarities with unknown protein 376619003197 FeS assembly protein SufD; Region: sufD; TIGR01981 376619003198 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 376619003199 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 376619003200 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 376619003201 Walker A/P-loop; other site 376619003202 ATP binding site [chemical binding]; other site 376619003203 Q-loop/lid; other site 376619003204 ABC transporter signature motif; other site 376619003205 Walker B; other site 376619003206 D-loop; other site 376619003207 H-loop/switch region; other site 376619003208 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 376619003209 putative ABC transporter; Region: ycf24; CHL00085 376619003210 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 376619003211 Transcriptional regulator; Region: Rrf2; pfam02082 376619003212 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 376619003213 TrkA-N domain; Region: TrkA_N; pfam02254 376619003214 TrkA-N domain; Region: TrkA_N; pfam02254 376619003215 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 376619003216 inner membrane protein, pseudogene 376619003217 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 376619003218 rRNA binding site [nucleotide binding]; other site 376619003219 predicted 30S ribosome binding site; other site 376619003220 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 376619003221 signal recognition particle protein; Provisional; Region: PRK10867 376619003222 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 376619003223 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 376619003224 P loop; other site 376619003225 GTP binding site [chemical binding]; other site 376619003226 Signal peptide binding domain; Region: SRP_SPB; pfam02978 376619003227 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 376619003228 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 376619003229 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619003230 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619003231 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619003232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619003233 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 376619003234 conserved cys residue [active] 376619003235 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 376619003236 active site 376619003237 Zn binding site [ion binding]; other site 376619003238 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 376619003239 putative active site [active] 376619003240 putative catalytic site [active] 376619003241 putative DNA binding site [nucleotide binding]; other site 376619003242 putative phosphate binding site [ion binding]; other site 376619003243 metal binding site A [ion binding]; metal-binding site 376619003244 putative AP binding site [nucleotide binding]; other site 376619003245 putative metal binding site B [ion binding]; other site 376619003246 short chain dehydrogenase; Provisional; Region: PRK07577 376619003247 classical (c) SDRs; Region: SDR_c; cd05233 376619003248 NAD(P) binding site [chemical binding]; other site 376619003249 active site 376619003250 AAA domain; Region: AAA_17; pfam13207 376619003251 AAA domain; Region: AAA_18; pfam13238 376619003252 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 376619003253 glutathione reductase; Validated; Region: PRK06116 376619003254 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 376619003255 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 376619003256 Uncharacterized conserved protein [Function unknown]; Region: COG0393 376619003257 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619003258 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619003259 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619003260 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 376619003261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619003262 putative substrate translocation pore; other site 376619003263 POT family; Region: PTR2; cl17359 376619003264 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 376619003265 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 376619003266 ATP binding site [chemical binding]; other site 376619003267 Mg++ binding site [ion binding]; other site 376619003268 motif III; other site 376619003269 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 376619003270 nucleotide binding region [chemical binding]; other site 376619003271 ATP-binding site [chemical binding]; other site 376619003272 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 376619003273 GTP cyclohydrolase I; Provisional; Region: PLN03044 376619003274 active site 376619003275 hypothetical protein 376619003276 conserved hypothetical protein, pseudogene 376619003277 hypothetical protein 376619003278 conserved hypothetical membrane protein,pseudogene 376619003279 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 376619003280 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 376619003281 active site 376619003282 catalytic tetrad [active] 376619003283 major facilitator superfamily (MFS) transport protein, pseudogene 376619003284 hypothetical protein 376619003285 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 376619003286 Glutamine amidotransferase class-I; Region: GATase; pfam00117 376619003287 glutamine binding [chemical binding]; other site 376619003288 catalytic triad [active] 376619003289 aminodeoxychorismate synthase; Provisional; Region: PRK07508 376619003290 chorismate binding enzyme; Region: Chorismate_bind; cl10555 376619003291 Aminotransferase class IV; Region: Aminotran_4; pfam01063 376619003292 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 376619003293 substrate-cofactor binding pocket; other site 376619003294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 376619003295 catalytic residue [active] 376619003296 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 376619003297 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 376619003298 acyl-activating enzyme (AAE) consensus motif; other site 376619003299 AMP binding site [chemical binding]; other site 376619003300 active site 376619003301 CoA binding site [chemical binding]; other site 376619003302 Dihydroneopterin aldolase; Region: FolB; smart00905 376619003303 active site 376619003304 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 376619003305 catalytic center binding site [active] 376619003306 ATP binding site [chemical binding]; other site 376619003307 dihydropteroate synthase; Region: DHPS; TIGR01496 376619003308 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 376619003309 substrate binding pocket [chemical binding]; other site 376619003310 dimer interface [polypeptide binding]; other site 376619003311 inhibitor binding site; inhibition site 376619003312 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 376619003313 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 376619003314 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 376619003315 active site 2 [active] 376619003316 active site 1 [active] 376619003317 adenosine deaminase 376619003318 adenosine deaminase 376619003319 adenosine deaminase 376619003320 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 376619003321 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 376619003322 inhibitor-cofactor binding pocket; inhibition site 376619003323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 376619003324 catalytic residue [active] 376619003325 biotin synthase; Region: bioB; TIGR00433 376619003326 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 376619003327 FeS/SAM binding site; other site 376619003328 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 376619003329 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 376619003330 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 376619003331 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 376619003332 catalytic residue [active] 376619003333 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 376619003334 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 376619003335 AAA domain; Region: AAA_26; pfam13500 376619003336 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 376619003337 dimerization interface [polypeptide binding]; other site 376619003338 putative DNA binding site [nucleotide binding]; other site 376619003339 putative Zn2+ binding site [ion binding]; other site 376619003340 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 376619003341 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 376619003342 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 376619003343 nucleotide binding site [chemical binding]; other site 376619003344 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 376619003345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619003346 putative substrate translocation pore; other site 376619003347 acetoacetate decarboxylase; Provisional; Region: PRK02265 376619003348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 376619003349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 376619003350 NAD(P) binding site [chemical binding]; other site 376619003351 active site 376619003352 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 376619003353 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 376619003354 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 376619003355 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 376619003356 inhibitor-cofactor binding pocket; inhibition site 376619003357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 376619003358 catalytic residue [active] 376619003359 glutathione synthetase; Provisional; Region: PRK05246 376619003360 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 376619003361 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 376619003362 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 376619003363 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 376619003364 putative active site [active] 376619003365 substrate binding site [chemical binding]; other site 376619003366 putative cosubstrate binding site; other site 376619003367 catalytic site [active] 376619003368 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 376619003369 substrate binding site [chemical binding]; other site 376619003370 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 376619003371 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 376619003372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 376619003373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 376619003374 S-adenosylmethionine binding site [chemical binding]; other site 376619003375 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 376619003376 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 376619003377 active site 376619003378 nucleic acid binding site [nucleotide binding]; other site 376619003379 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619003380 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619003381 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619003382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619003383 HI0933-like protein; Region: HI0933_like; pfam03486 376619003384 HI0933-like protein; Region: HI0933_like; pfam03486 376619003385 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 376619003386 short chain dehydrogenase; Provisional; Region: PRK05993 376619003387 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 376619003388 NADP binding site [chemical binding]; other site 376619003389 active site 376619003390 steroid binding site; other site 376619003391 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 376619003392 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 376619003393 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619003394 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619003395 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619003396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619003397 SnoaL-like domain; Region: SnoaL_2; pfam12680 376619003398 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 376619003399 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619003400 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619003401 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619003402 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 376619003403 ferredoxin-NADP reductase; Provisional; Region: PRK10926 376619003404 FAD binding pocket [chemical binding]; other site 376619003405 FAD binding motif [chemical binding]; other site 376619003406 phosphate binding motif [ion binding]; other site 376619003407 beta-alpha-beta structure motif; other site 376619003408 NAD binding pocket [chemical binding]; other site 376619003409 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 376619003410 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 376619003411 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 376619003412 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 376619003413 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 376619003414 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 376619003415 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 376619003416 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 376619003417 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 376619003418 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 376619003419 active site 376619003420 multimer interface [polypeptide binding]; other site 376619003421 CTP synthetase; Validated; Region: pyrG; PRK05380 376619003422 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 376619003423 Catalytic site [active] 376619003424 active site 376619003425 UTP binding site [chemical binding]; other site 376619003426 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 376619003427 active site 376619003428 putative oxyanion hole; other site 376619003429 catalytic triad [active] 376619003430 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 376619003431 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 376619003432 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619003433 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619003434 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619003435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619003436 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 376619003437 hypothetical protein 376619003438 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619003439 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619003440 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 376619003441 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 376619003442 conserved hypothetical protein 376619003443 conserved hypothetical protein, pseudogene 376619003444 hypothetical protein 376619003445 hypothetical protein 376619003446 CRISPR/Cas system-associated protein Cas9; Region: Csx12; cd09704 376619003447 CRISPR/Cas system-associated protein Cas9; Region: Csx12; cd09704 376619003448 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 376619003449 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 376619003450 ligand binding site [chemical binding]; other site 376619003451 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 376619003452 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 376619003453 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 376619003454 active site 376619003455 (T/H)XGH motif; other site 376619003456 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 376619003457 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 376619003458 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 376619003459 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 376619003460 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 376619003461 catalytic residue [active] 376619003462 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 376619003463 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 376619003464 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 376619003465 Protein of unknown function DUF45; Region: DUF45; pfam01863 376619003466 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 376619003467 Prephenate dehydratase; Region: PDT; pfam00800 376619003468 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 376619003469 putative L-Phe binding site [chemical binding]; other site 376619003470 amino acid permease family protein, pseudogene 376619003471 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 376619003472 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 376619003473 active site 376619003474 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 376619003475 dimer interface [polypeptide binding]; other site 376619003476 substrate binding site [chemical binding]; other site 376619003477 catalytic residues [active] 376619003478 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 376619003479 POT family; Region: PTR2; cl17359 376619003480 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 376619003481 putative C-terminal domain interface [polypeptide binding]; other site 376619003482 putative GSH binding site [chemical binding]; other site 376619003483 putative dimer interface [polypeptide binding]; other site 376619003484 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 376619003485 dimer interface [polypeptide binding]; other site 376619003486 substrate binding pocket (H-site) [chemical binding]; other site 376619003487 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 376619003488 putative N-terminal domain interface [polypeptide binding]; other site 376619003489 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 376619003490 hypothetical protein; Provisional; Region: PRK14013 376619003491 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 376619003492 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 376619003493 conserved hypothetical membrane protein,pseudogene 376619003494 hypothetical protein 376619003495 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619003496 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619003497 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619003498 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619003499 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619003500 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619003501 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619003502 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 376619003503 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 376619003504 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 376619003505 active site 376619003506 recombination protein F; Reviewed; Region: recF; PRK00064 376619003507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 376619003508 Walker A/P-loop; other site 376619003509 ATP binding site [chemical binding]; other site 376619003510 Q-loop/lid; other site 376619003511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 376619003512 ABC transporter signature motif; other site 376619003513 Walker B; other site 376619003514 D-loop; other site 376619003515 H-loop/switch region; other site 376619003516 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 376619003517 EamA-like transporter family; Region: EamA; pfam00892 376619003518 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 376619003519 EamA-like transporter family; Region: EamA; pfam00892 376619003520 Acetyl-coenzyme A synthetase, pseudogene 376619003521 acetyl-CoA synthetase 376619003522 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 376619003523 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 376619003524 active site 376619003525 tetramer interface; other site 376619003526 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 376619003527 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 376619003528 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 376619003529 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 376619003530 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 376619003531 DNA-binding site [nucleotide binding]; DNA binding site 376619003532 RNA-binding motif; other site 376619003533 Radical SAM superfamily; Region: Radical_SAM; pfam04055 376619003534 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 376619003535 FeS/SAM binding site; other site 376619003536 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 376619003537 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 376619003538 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 376619003539 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 376619003540 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 376619003541 non-specific DNA interactions [nucleotide binding]; other site 376619003542 DNA binding site [nucleotide binding] 376619003543 sequence specific DNA binding site [nucleotide binding]; other site 376619003544 putative cAMP binding site [chemical binding]; other site 376619003545 Bacterial transcriptional regulator; Region: IclR; pfam01614 376619003546 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 376619003547 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 376619003548 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 376619003549 Fusaric acid resistance protein family; Region: FUSC; pfam04632 376619003550 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619003551 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619003552 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619003553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619003554 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 376619003555 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 376619003556 Organic solvent tolerance protein; Region: OstA_C; pfam04453 376619003557 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 376619003558 RNA binding surface [nucleotide binding]; other site 376619003559 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 376619003560 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 376619003561 putative substrate binding site [chemical binding]; other site 376619003562 putative ATP binding site [chemical binding]; other site 376619003563 Putative serine esterase (DUF676); Region: DUF676; pfam05057 376619003564 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 376619003565 mandelate racemase/muconate lactonizing enzyme family protein 376619003566 mandelate racemase/muconate lactonizing enzyme family protein, pseudogene 376619003567 conserved hypothetical protein 376619003568 conserved hypothetical protein 376619003569 conserved hypothetical membrane protein 376619003570 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 376619003571 catalytic residues [active] 376619003572 dimer interface [polypeptide binding]; other site 376619003573 Chorismate mutase type II; Region: CM_2; smart00830 376619003574 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619003575 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619003576 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619003577 adenosine deaminase, pseudogene 376619003578 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 376619003579 L-aspartate oxidase; Provisional; Region: PRK06175 376619003580 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 376619003581 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 376619003582 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 376619003583 dimerization interface [polypeptide binding]; other site 376619003584 active site 376619003585 quinolinate synthetase; Provisional; Region: PRK09375 376619003586 Guanylate kinase; Region: Guanylate_kin; pfam00625 376619003587 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 376619003588 catalytic site [active] 376619003589 G-X2-G-X-G-K; other site 376619003590 helicase 45; Provisional; Region: PTZ00424 376619003591 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 376619003592 ATP binding site [chemical binding]; other site 376619003593 Mg++ binding site [ion binding]; other site 376619003594 motif III; other site 376619003595 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 376619003596 nucleotide binding region [chemical binding]; other site 376619003597 ATP-binding site [chemical binding]; other site 376619003598 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 376619003599 putative RNA binding site [nucleotide binding]; other site 376619003600 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 376619003601 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 376619003602 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 376619003603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619003604 putative substrate translocation pore; other site 376619003605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619003606 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 376619003607 putative substrate translocation pore; other site 376619003608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619003609 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 376619003610 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 376619003611 dimer interface [polypeptide binding]; other site 376619003612 active site 376619003613 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 376619003614 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 376619003615 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 376619003616 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 376619003617 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 376619003618 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 376619003619 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 376619003620 Ligand binding site; other site 376619003621 oligomer interface; other site 376619003622 Uncharacterized conserved protein [Function unknown]; Region: COG2835 376619003623 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 376619003624 active site 376619003625 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619003626 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619003627 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619003628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619003629 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 376619003630 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 376619003631 23S rRNA binding site [nucleotide binding]; other site 376619003632 L21 binding site [polypeptide binding]; other site 376619003633 L13 binding site [polypeptide binding]; other site 376619003634 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 376619003635 translation initiation factor IF-3; Region: infC; TIGR00168 376619003636 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 376619003637 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 376619003638 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 376619003639 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 376619003640 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 376619003641 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 376619003642 active site 376619003643 dimer interface [polypeptide binding]; other site 376619003644 motif 1; other site 376619003645 motif 2; other site 376619003646 motif 3; other site 376619003647 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 376619003648 anticodon binding site; other site 376619003649 Chitin binding domain; Region: Chitin_bind_3; pfam03067 376619003650 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 376619003651 aromatic chitin/cellulose binding site residues [chemical binding]; other site 376619003652 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 376619003653 lipoyl attachment site [posttranslational modification]; other site 376619003654 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 376619003655 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 376619003656 homodimer interface [polypeptide binding]; other site 376619003657 active site 376619003658 hypothetical protein; Validated; Region: PRK00153 376619003659 recombination protein RecR; Provisional; Region: PRK13844 376619003660 RecR protein; Region: RecR; pfam02132 376619003661 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 376619003662 putative active site [active] 376619003663 putative metal-binding site [ion binding]; other site 376619003664 tetramer interface [polypeptide binding]; other site 376619003665 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 376619003666 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 376619003667 Zn2+ binding site [ion binding]; other site 376619003668 Mg2+ binding site [ion binding]; other site 376619003669 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 376619003670 synthetase active site [active] 376619003671 NTP binding site [chemical binding]; other site 376619003672 metal binding site [ion binding]; metal-binding site 376619003673 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 376619003674 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 376619003675 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 376619003676 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 376619003677 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 376619003678 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 376619003679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619003680 metabolite-proton symporter; Region: 2A0106; TIGR00883 376619003681 putative substrate translocation pore; other site 376619003682 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 376619003683 catalytic nucleophile [active] 376619003684 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 376619003685 proposed catalytic triad [active] 376619003686 active site nucleophile [active] 376619003687 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 376619003688 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 376619003689 substrate binding site [chemical binding]; other site 376619003690 ATP binding site [chemical binding]; other site 376619003691 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 376619003692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 376619003693 motif II; other site 376619003694 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 376619003695 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 376619003696 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 376619003697 active site 376619003698 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 376619003699 active site 376619003700 LicD family; Region: LicD; pfam04991 376619003701 Methyltransferase domain; Region: Methyltransf_23; pfam13489 376619003702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 376619003703 S-adenosylmethionine binding site [chemical binding]; other site 376619003704 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 376619003705 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 376619003706 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 376619003707 active site 376619003708 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 376619003709 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 376619003710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 376619003711 Walker A/P-loop; other site 376619003712 ATP binding site [chemical binding]; other site 376619003713 Q-loop/lid; other site 376619003714 ABC transporter signature motif; other site 376619003715 Walker B; other site 376619003716 D-loop; other site 376619003717 H-loop/switch region; other site 376619003718 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 376619003719 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 376619003720 putative ADP-binding pocket [chemical binding]; other site 376619003721 UDP-glucose 4-epimerase; Region: PLN02240 376619003722 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 376619003723 NAD binding site [chemical binding]; other site 376619003724 homodimer interface [polypeptide binding]; other site 376619003725 active site 376619003726 substrate binding site [chemical binding]; other site 376619003727 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 376619003728 Bacterial sugar transferase; Region: Bac_transf; pfam02397 376619003729 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 376619003730 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 376619003731 substrate binding site [chemical binding]; other site 376619003732 hexamer interface [polypeptide binding]; other site 376619003733 metal binding site [ion binding]; metal-binding site 376619003734 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 376619003735 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 376619003736 putative active site [active] 376619003737 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 376619003738 DoxX; Region: DoxX; pfam07681 376619003739 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 376619003740 hypothetical protein; Provisional; Region: PRK05409 376619003741 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 376619003742 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 376619003743 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619003744 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619003745 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619003746 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 376619003747 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 376619003748 NAD binding site [chemical binding]; other site 376619003749 homotetramer interface [polypeptide binding]; other site 376619003750 homodimer interface [polypeptide binding]; other site 376619003751 substrate binding site [chemical binding]; other site 376619003752 active site 376619003753 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 376619003754 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619003755 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619003756 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619003757 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619003758 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619003759 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619003760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619003761 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 376619003762 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 376619003763 GIY-YIG motif/motif A; other site 376619003764 active site 376619003765 catalytic site [active] 376619003766 putative DNA binding site [nucleotide binding]; other site 376619003767 metal binding site [ion binding]; metal-binding site 376619003768 UvrB/uvrC motif; Region: UVR; pfam02151 376619003769 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 376619003770 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 376619003771 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 376619003772 catalytic site [active] 376619003773 putative active site [active] 376619003774 putative substrate binding site [chemical binding]; other site 376619003775 HRDC domain; Region: HRDC; pfam00570 376619003776 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 376619003777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619003778 putative substrate translocation pore; other site 376619003779 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 376619003780 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 376619003781 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 376619003782 glycerate kinase 376619003783 glycerate kinase, pseudogene 376619003784 DNA-3-methyladenine glycosylase I (pseudogene) 376619003785 3-methyladenine DNA glycosylase 376619003786 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 376619003787 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 376619003788 ATP binding site [chemical binding]; other site 376619003789 putative Mg++ binding site [ion binding]; other site 376619003790 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 376619003791 SEC-C motif; Region: SEC-C; pfam02810 376619003792 LPP20 lipoprotein; Region: LPP20; cl15824 376619003793 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 376619003794 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619003795 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619003796 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619003797 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619003798 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619003799 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619003800 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619003801 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 376619003802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 376619003803 Walker A motif; other site 376619003804 ATP binding site [chemical binding]; other site 376619003805 Walker B motif; other site 376619003806 arginine finger; other site 376619003807 Peptidase family M41; Region: Peptidase_M41; pfam01434 376619003808 putative transporter; Provisional; Region: PRK10504 376619003809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619003810 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619003811 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619003812 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619003813 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 376619003814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 376619003815 Walker A motif; other site 376619003816 ATP binding site [chemical binding]; other site 376619003817 Walker B motif; other site 376619003818 arginine finger; other site 376619003819 Peptidase family M41; Region: Peptidase_M41; pfam01434 376619003820 putative transporter; Provisional; Region: PRK10504 376619003821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619003822 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619003823 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619003824 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619003825 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 376619003826 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 376619003827 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 376619003828 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 376619003829 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 376619003830 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 376619003831 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 376619003832 Type II transport protein GspH; Region: GspH; pfam12019 376619003833 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 376619003834 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 376619003835 active site 376619003836 dimer interface [polypeptide binding]; other site 376619003837 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 376619003838 dimer interface [polypeptide binding]; other site 376619003839 active site 376619003840 Thiamine pyrophosphokinase; Region: TPK; cd07995 376619003841 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 376619003842 active site 376619003843 dimerization interface [polypeptide binding]; other site 376619003844 thiamine binding site [chemical binding]; other site 376619003845 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 376619003846 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 376619003847 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 376619003848 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 376619003849 active site 376619003850 multifunctional aminopeptidase A; Provisional; Region: PRK00913 376619003851 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 376619003852 interface (dimer of trimers) [polypeptide binding]; other site 376619003853 Substrate-binding/catalytic site; other site 376619003854 Zn-binding sites [ion binding]; other site 376619003855 Predicted permeases [General function prediction only]; Region: COG0795 376619003856 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 376619003857 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 376619003858 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 376619003859 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 376619003860 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 376619003861 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 376619003862 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 376619003863 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 376619003864 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 376619003865 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 376619003866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 376619003867 Predicted membrane protein [Function unknown]; Region: COG2860 376619003868 UPF0126 domain; Region: UPF0126; pfam03458 376619003869 UPF0126 domain; Region: UPF0126; pfam03458 376619003870 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 376619003871 active site 376619003872 dinuclear metal binding site [ion binding]; other site 376619003873 dimerization interface [polypeptide binding]; other site 376619003874 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 376619003875 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 376619003876 active site 376619003877 catalytic motif [active] 376619003878 Zn binding site [ion binding]; other site 376619003879 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 376619003880 FAD binding domain; Region: FAD_binding_4; pfam01565 376619003881 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 376619003882 phosphoglyceromutase; Provisional; Region: PRK05434 376619003883 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 376619003884 seryl-tRNA synthetase; Provisional; Region: PRK05431 376619003885 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 376619003886 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 376619003887 dimer interface [polypeptide binding]; other site 376619003888 active site 376619003889 motif 1; other site 376619003890 motif 2; other site 376619003891 motif 3; other site 376619003892 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 376619003893 ROK family; Region: ROK; pfam00480 376619003894 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 376619003895 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 376619003896 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 376619003897 Walker A/P-loop; other site 376619003898 ATP binding site [chemical binding]; other site 376619003899 Q-loop/lid; other site 376619003900 ABC transporter signature motif; other site 376619003901 Walker B; other site 376619003902 D-loop; other site 376619003903 H-loop/switch region; other site 376619003904 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 376619003905 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 376619003906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 376619003907 Walker A/P-loop; other site 376619003908 ATP binding site [chemical binding]; other site 376619003909 Q-loop/lid; other site 376619003910 ABC transporter signature motif; other site 376619003911 Walker B; other site 376619003912 D-loop; other site 376619003913 H-loop/switch region; other site 376619003914 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 376619003915 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 376619003916 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 376619003917 homotrimer interaction site [polypeptide binding]; other site 376619003918 putative active site [active] 376619003919 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 376619003920 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 376619003921 Sulfate transporter family; Region: Sulfate_transp; pfam00916 376619003922 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 376619003923 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619003924 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619003925 hypothetical protein 376619003926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619003927 metabolite-proton symporter; Region: 2A0106; TIGR00883 376619003928 putative substrate translocation pore; other site 376619003929 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 376619003930 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 376619003931 Zn2+ binding site [ion binding]; other site 376619003932 Mg2+ binding site [ion binding]; other site 376619003933 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 376619003934 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 376619003935 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 376619003936 heme binding site [chemical binding]; other site 376619003937 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 376619003938 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619003939 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619003940 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619003941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619003942 classical (c) SDRs; Region: SDR_c; cd05233 376619003943 active site 376619003944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 376619003945 D-alanyl-D-alanine carboxypeptidase (Penicillin binding protein) family protein, pseudogene 376619003946 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 376619003947 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 376619003948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619003949 putative substrate translocation pore; other site 376619003950 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 376619003951 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 376619003952 active site 376619003953 catalytic site [active] 376619003954 metal binding site [ion binding]; metal-binding site 376619003955 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 376619003956 HlyD family secretion protein; Region: HlyD_3; pfam13437 376619003957 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 376619003958 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 376619003959 Walker A/P-loop; other site 376619003960 ATP binding site [chemical binding]; other site 376619003961 Q-loop/lid; other site 376619003962 ABC transporter signature motif; other site 376619003963 Walker B; other site 376619003964 D-loop; other site 376619003965 H-loop/switch region; other site 376619003966 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 376619003967 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 376619003968 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 376619003969 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619003970 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619003971 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619003972 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 376619003973 putative substrate binding pocket [chemical binding]; other site 376619003974 trimer interface [polypeptide binding]; other site 376619003975 formyltetrahydrofolate deformylase, pseudogene 376619003976 amino acid-binding ACT 376619003977 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 376619003978 active site 376619003979 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 376619003980 Glyco_18 domain; Region: Glyco_18; smart00636 376619003981 active site 376619003982 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 376619003983 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 376619003984 aromatic chitin/cellulose binding site residues [chemical binding]; other site 376619003985 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 376619003986 aromatic chitin/cellulose binding site residues [chemical binding]; other site 376619003987 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 376619003988 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 376619003989 substrate-cofactor binding pocket; other site 376619003990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 376619003991 catalytic residue [active] 376619003992 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 376619003993 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 376619003994 NAD(P) binding site [chemical binding]; other site 376619003995 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 376619003996 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 376619003997 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 376619003998 substrate binding site; other site 376619003999 dimer interface; other site 376619004000 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 376619004001 Septum formation initiator; Region: DivIC; cl17659 376619004002 enolase; Provisional; Region: eno; PRK00077 376619004003 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 376619004004 dimer interface [polypeptide binding]; other site 376619004005 metal binding site [ion binding]; metal-binding site 376619004006 substrate binding pocket [chemical binding]; other site 376619004007 Major Facilitator Superfamily; Region: MFS_1; pfam07690 376619004008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004009 putative substrate translocation pore; other site 376619004010 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 376619004011 glucose kinase, pseudogene 376619004012 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 376619004013 TRAM domain; Region: TRAM; pfam01938 376619004014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 376619004015 S-adenosylmethionine binding site [chemical binding]; other site 376619004016 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 376619004017 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 376619004018 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 376619004019 ATP-binding site [chemical binding]; other site 376619004020 Sugar specificity; other site 376619004021 Pyrimidine base specificity; other site 376619004022 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 376619004023 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 376619004024 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 376619004025 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 376619004026 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 376619004027 oligomer interface [polypeptide binding]; other site 376619004028 RNA binding site [nucleotide binding]; other site 376619004029 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 376619004030 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 376619004031 RNase E interface [polypeptide binding]; other site 376619004032 trimer interface [polypeptide binding]; other site 376619004033 active site 376619004034 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 376619004035 putative nucleic acid binding region [nucleotide binding]; other site 376619004036 G-X-X-G motif; other site 376619004037 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 376619004038 RNA binding site [nucleotide binding]; other site 376619004039 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 376619004040 16S/18S rRNA binding site [nucleotide binding]; other site 376619004041 S13e-L30e interaction site [polypeptide binding]; other site 376619004042 25S rRNA binding site [nucleotide binding]; other site 376619004043 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 376619004044 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 376619004045 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 376619004046 Cell division protein FtsL; Region: FtsL; cl11433 376619004047 MraW methylase family; Region: Methyltransf_5; cl17771 376619004048 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 376619004049 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 376619004050 AMP-binding enzyme; Region: AMP-binding; pfam00501 376619004051 acyl-activating enzyme (AAE) consensus motif; other site 376619004052 putative AMP binding site [chemical binding]; other site 376619004053 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 376619004054 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 376619004055 DNA binding site [nucleotide binding] 376619004056 catalytic residue [active] 376619004057 H2TH interface [polypeptide binding]; other site 376619004058 putative catalytic residues [active] 376619004059 turnover-facilitating residue; other site 376619004060 intercalation triad [nucleotide binding]; other site 376619004061 8OG recognition residue [nucleotide binding]; other site 376619004062 putative reading head residues; other site 376619004063 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 376619004064 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 376619004065 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619004066 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619004067 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619004068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619004069 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 376619004070 predicted active site [active] 376619004071 catalytic triad [active] 376619004072 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 376619004073 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 376619004074 active site 376619004075 multimer interface [polypeptide binding]; other site 376619004076 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 376619004077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 376619004078 ATP binding site [chemical binding]; other site 376619004079 Mg2+ binding site [ion binding]; other site 376619004080 G-X-G motif; other site 376619004081 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 376619004082 anchoring element; other site 376619004083 dimer interface [polypeptide binding]; other site 376619004084 ATP binding site [chemical binding]; other site 376619004085 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 376619004086 active site 376619004087 putative metal-binding site [ion binding]; other site 376619004088 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 376619004089 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 376619004090 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 376619004091 FMN binding site [chemical binding]; other site 376619004092 active site 376619004093 catalytic residues [active] 376619004094 substrate binding site [chemical binding]; other site 376619004095 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 376619004096 TIGR03546 family protein; Region: TIGR03546 376619004097 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 376619004098 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 376619004099 CoA-ligase; Region: Ligase_CoA; pfam00549 376619004100 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 376619004101 CoA binding domain; Region: CoA_binding; smart00881 376619004102 CoA-ligase; Region: Ligase_CoA; pfam00549 376619004103 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 376619004104 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 376619004105 hypothetical protein; Provisional; Region: PRK07206 376619004106 ATP-grasp domain; Region: ATP-grasp_4; cl17255 376619004107 Di-tripeptide transporter 376619004108 Di-tripeptide transporter 376619004109 Di-tripeptide transporter 376619004110 Asparaginase 2 family protein 376619004111 hypothetical protein 376619004112 hypothetical protein 376619004113 conserved hypothetical protein 376619004114 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 376619004115 MFS transport protein AraJ; Provisional; Region: PRK10091 376619004116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004117 putative substrate translocation pore; other site 376619004118 Transcriptional regulator [Transcription]; Region: LysR; COG0583 376619004119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 376619004120 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 376619004121 putative effector binding pocket; other site 376619004122 dimerization interface [polypeptide binding]; other site 376619004123 phosphoglycolate phosphatase; Provisional; Region: PRK13222 376619004124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 376619004125 motif II; other site 376619004126 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 376619004127 PLD-like domain; Region: PLDc_2; pfam13091 376619004128 putative active site [active] 376619004129 catalytic site [active] 376619004130 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 376619004131 PLD-like domain; Region: PLDc_2; pfam13091 376619004132 putative active site [active] 376619004133 putative catalytic site [active] 376619004134 thioredoxin reductase; Provisional; Region: PRK10262 376619004135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 376619004136 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 376619004137 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619004138 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619004139 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619004140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004141 Major Facilitator Superfamily; Region: MFS_1; pfam07690 376619004142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004143 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 376619004144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 376619004145 ATP binding site [chemical binding]; other site 376619004146 Mg2+ binding site [ion binding]; other site 376619004147 G-X-G motif; other site 376619004148 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 376619004149 ATP binding site [chemical binding]; other site 376619004150 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 376619004151 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 376619004152 Predicted GTPases [General function prediction only]; Region: COG1162 376619004153 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 376619004154 RNA binding site [nucleotide binding]; other site 376619004155 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 376619004156 GTPase/Zn-binding domain interface [polypeptide binding]; other site 376619004157 GTP/Mg2+ binding site [chemical binding]; other site 376619004158 G4 box; other site 376619004159 G5 box; other site 376619004160 G1 box; other site 376619004161 Switch I region; other site 376619004162 G2 box; other site 376619004163 G3 box; other site 376619004164 Switch II region; other site 376619004165 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 376619004166 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 376619004167 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 376619004168 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 376619004169 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 376619004170 Domain of unknown function DUF20; Region: UPF0118; pfam01594 376619004171 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 376619004172 DHH family; Region: DHH; pfam01368 376619004173 DHHA1 domain; Region: DHHA1; pfam02272 376619004174 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 376619004175 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 376619004176 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 376619004177 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 376619004178 motif 1; other site 376619004179 dimer interface [polypeptide binding]; other site 376619004180 active site 376619004181 motif 2; other site 376619004182 motif 3; other site 376619004183 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 376619004184 Mechanosensitive ion channel; Region: MS_channel; pfam00924 376619004185 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619004186 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619004187 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619004188 Helix-turn-helix domain; Region: HTH_25; pfam13413 376619004189 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 376619004190 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 376619004191 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 376619004192 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 376619004193 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 376619004194 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 376619004195 carboxyltransferase (CT) interaction site; other site 376619004196 biotinylation site [posttranslational modification]; other site 376619004197 Dehydroquinase class II; Region: DHquinase_II; pfam01220 376619004198 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 376619004199 trimer interface [polypeptide binding]; other site 376619004200 active site 376619004201 dimer interface [polypeptide binding]; other site 376619004202 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 376619004203 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 376619004204 active site 376619004205 metal binding site [ion binding]; metal-binding site 376619004206 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 376619004207 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 376619004208 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 376619004209 SurA N-terminal domain; Region: SurA_N; pfam09312 376619004210 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 376619004211 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 376619004212 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 376619004213 Organic solvent tolerance protein; Region: OstA_C; pfam04453 376619004214 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 376619004215 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 376619004216 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 376619004217 active site 376619004218 HIGH motif; other site 376619004219 nucleotide binding site [chemical binding]; other site 376619004220 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 376619004221 KMSK motif region; other site 376619004222 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 376619004223 tRNA binding surface [nucleotide binding]; other site 376619004224 anticodon binding site; other site 376619004225 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 376619004226 active site 376619004227 homodimer interface [polypeptide binding]; other site 376619004228 homotetramer interface [polypeptide binding]; other site 376619004229 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 376619004230 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 376619004231 dimer interface [polypeptide binding]; other site 376619004232 active site 376619004233 Schiff base residues; other site 376619004234 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 376619004235 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 376619004236 DNA polymerase III subunit delta'; Validated; Region: PRK08485 376619004237 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 376619004238 putative inner membrane peptidase; Provisional; Region: PRK11778 376619004239 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 376619004240 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 376619004241 tandem repeat interface [polypeptide binding]; other site 376619004242 oligomer interface [polypeptide binding]; other site 376619004243 active site residues [active] 376619004244 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 376619004245 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 376619004246 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 376619004247 dimer interface [polypeptide binding]; other site 376619004248 N-terminal domain interface [polypeptide binding]; other site 376619004249 DsrC like protein; Region: DsrC; pfam04358 376619004250 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 376619004251 oxidative damage protection protein; Provisional; Region: PRK05408 376619004252 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 376619004253 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 376619004254 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619004255 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619004256 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619004257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619004258 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 376619004259 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 376619004260 Ligand binding site; other site 376619004261 Putative Catalytic site; other site 376619004262 DXD motif; other site 376619004263 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 376619004264 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 376619004265 putative active site [active] 376619004266 YdjC motif; other site 376619004267 Mg binding site [ion binding]; other site 376619004268 putative homodimer interface [polypeptide binding]; other site 376619004269 cell division protein FtsW; Region: ftsW; TIGR02614 376619004270 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 376619004271 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 376619004272 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 376619004273 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 376619004274 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 376619004275 Mg++ binding site [ion binding]; other site 376619004276 putative catalytic motif [active] 376619004277 putative substrate binding site [chemical binding]; other site 376619004278 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 376619004279 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 376619004280 active site 376619004281 metal-binding site [ion binding] 376619004282 nucleotide-binding site [chemical binding]; other site 376619004283 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 376619004284 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 376619004285 active site 376619004286 HIGH motif; other site 376619004287 nucleotide binding site [chemical binding]; other site 376619004288 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 376619004289 KMSKS motif; other site 376619004290 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 376619004291 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 376619004292 POT family; Region: PTR2; cl17359 376619004293 ABC transporter ATPase component; Reviewed; Region: PRK11147 376619004294 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 376619004295 Walker A/P-loop; other site 376619004296 ATP binding site [chemical binding]; other site 376619004297 Q-loop/lid; other site 376619004298 ABC transporter signature motif; other site 376619004299 Walker B; other site 376619004300 D-loop; other site 376619004301 H-loop/switch region; other site 376619004302 ABC transporter; Region: ABC_tran_2; pfam12848 376619004303 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 376619004304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004305 Major Facilitator Superfamily; Region: MFS_1; pfam07690 376619004306 putative substrate translocation pore; other site 376619004307 Predicted membrane protein [Function unknown]; Region: COG4129 376619004308 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 376619004309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004310 putative substrate translocation pore; other site 376619004311 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 376619004312 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 376619004313 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 376619004314 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619004315 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619004316 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619004317 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619004318 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619004319 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619004320 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619004321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619004322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 376619004323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 376619004324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 376619004325 dimerization interface [polypeptide binding]; other site 376619004326 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 376619004327 aromatic chitin/cellulose binding site residues [chemical binding]; other site 376619004328 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 376619004329 aromatic chitin/cellulose binding site residues [chemical binding]; other site 376619004330 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 376619004331 active site 376619004332 VacJ like lipoprotein; Region: VacJ; cl01073 376619004333 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 376619004334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 376619004335 S-adenosylmethionine binding site [chemical binding]; other site 376619004336 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 376619004337 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 376619004338 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619004339 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619004340 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619004341 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619004342 glycerol kinase; Provisional; Region: glpK; PRK00047 376619004343 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 376619004344 N- and C-terminal domain interface [polypeptide binding]; other site 376619004345 active site 376619004346 MgATP binding site [chemical binding]; other site 376619004347 catalytic site [active] 376619004348 metal binding site [ion binding]; metal-binding site 376619004349 glycerol binding site [chemical binding]; other site 376619004350 homotetramer interface [polypeptide binding]; other site 376619004351 homodimer interface [polypeptide binding]; other site 376619004352 FBP binding site [chemical binding]; other site 376619004353 protein IIAGlc interface [polypeptide binding]; other site 376619004354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004355 putative substrate translocation pore; other site 376619004356 Major Facilitator Superfamily; Region: MFS_1; pfam07690 376619004357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004358 Major Facilitator Superfamily; Region: MFS_1; pfam07690 376619004359 putative substrate translocation pore; other site 376619004360 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 376619004361 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 376619004362 Walker A/P-loop; other site 376619004363 ATP binding site [chemical binding]; other site 376619004364 Q-loop/lid; other site 376619004365 ABC transporter signature motif; other site 376619004366 Walker B; other site 376619004367 D-loop; other site 376619004368 H-loop/switch region; other site 376619004369 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 376619004370 oligopeptide transporter, subunit C, ABC transporter, membrane protein, pseudogene 376619004371 oligopeptide transport system permease protein 376619004372 oligopeptide transporter, subunit B, ABC transporter, membrane protein, pseudogene 376619004373 oligopeptide transport system permease protein 376619004374 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 376619004375 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 376619004376 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 376619004377 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619004378 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619004379 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619004380 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 376619004381 Part of AAA domain; Region: AAA_19; pfam13245 376619004382 Family description; Region: UvrD_C_2; pfam13538 376619004383 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 376619004384 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 376619004385 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 376619004386 GTP binding site [chemical binding]; other site 376619004387 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 376619004388 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 376619004389 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 376619004390 G1 box; other site 376619004391 putative GEF interaction site [polypeptide binding]; other site 376619004392 GTP/Mg2+ binding site [chemical binding]; other site 376619004393 Switch I region; other site 376619004394 G2 box; other site 376619004395 G3 box; other site 376619004396 Switch II region; other site 376619004397 G4 box; other site 376619004398 G5 box; other site 376619004399 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 376619004400 thymidylate kinase; Validated; Region: tmk; PRK00698 376619004401 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 376619004402 TMP-binding site; other site 376619004403 ATP-binding site [chemical binding]; other site 376619004404 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 376619004405 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 376619004406 Nucleoside recognition; Region: Gate; pfam07670 376619004407 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 376619004408 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 376619004409 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 376619004410 Nucleoside recognition; Region: Gate; pfam07670 376619004411 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 376619004412 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 376619004413 intersubunit interface [polypeptide binding]; other site 376619004414 active site 376619004415 catalytic residue [active] 376619004416 phosphopentomutase; Provisional; Region: PRK05362 376619004417 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 376619004418 pantothenate kinase; Reviewed; Region: PRK13324 376619004419 DNA polymerase I; Provisional; Region: PRK05755 376619004420 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 376619004421 active site 376619004422 metal binding site 1 [ion binding]; metal-binding site 376619004423 putative 5' ssDNA interaction site; other site 376619004424 metal binding site 3; metal-binding site 376619004425 metal binding site 2 [ion binding]; metal-binding site 376619004426 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 376619004427 putative DNA binding site [nucleotide binding]; other site 376619004428 putative metal binding site [ion binding]; other site 376619004429 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 376619004430 active site 376619004431 catalytic site [active] 376619004432 substrate binding site [chemical binding]; other site 376619004433 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 376619004434 active site 376619004435 DNA binding site [nucleotide binding] 376619004436 catalytic site [active] 376619004437 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 376619004438 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 376619004439 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 376619004440 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 376619004441 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 376619004442 Walker A/P-loop; other site 376619004443 ATP binding site [chemical binding]; other site 376619004444 Q-loop/lid; other site 376619004445 ABC transporter signature motif; other site 376619004446 Walker B; other site 376619004447 D-loop; other site 376619004448 H-loop/switch region; other site 376619004449 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 376619004450 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 376619004451 active site 376619004452 NTP binding site [chemical binding]; other site 376619004453 metal binding triad [ion binding]; metal-binding site 376619004454 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 376619004455 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 376619004456 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 376619004457 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 376619004458 HlyD family secretion protein; Region: HlyD_3; pfam13437 376619004459 multidrug efflux protein; Reviewed; Region: PRK09579 376619004460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004461 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 376619004462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004463 hypothetical protein 376619004464 transposase, IS982 family 376619004465 Transposase, pseudogene 376619004466 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 376619004467 dimer interface [polypeptide binding]; other site 376619004468 catalytic triad [active] 376619004469 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 376619004470 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619004471 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619004472 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619004473 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619004474 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619004475 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619004476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619004477 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 376619004478 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 376619004479 active site 376619004480 HIGH motif; other site 376619004481 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 376619004482 KMSKS motif; other site 376619004483 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 376619004484 tRNA binding surface [nucleotide binding]; other site 376619004485 anticodon binding site; other site 376619004486 HemK family putative methylases; Region: hemK_fam; TIGR00536 376619004487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 376619004488 S-adenosylmethionine binding site [chemical binding]; other site 376619004489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004490 Major Facilitator Superfamily; Region: MFS_1; pfam07690 376619004491 putative substrate translocation pore; other site 376619004492 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 376619004493 Coenzyme A binding pocket [chemical binding]; other site 376619004494 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619004495 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619004496 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619004497 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619004498 hypothetical protein 376619004499 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 376619004500 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 376619004501 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 376619004502 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 376619004503 Domain of unknown function DUF21; Region: DUF21; pfam01595 376619004504 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 376619004505 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 376619004506 DXD motif; other site 376619004507 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 376619004508 Na binding site [ion binding]; other site 376619004509 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 376619004510 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 376619004511 putative active site [active] 376619004512 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 376619004513 lysine transporter; Provisional; Region: PRK10836 376619004514 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 376619004515 active site 376619004516 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 376619004517 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 376619004518 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 376619004519 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 376619004520 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 376619004521 Cation transport protein; Region: TrkH; cl17365 376619004522 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 376619004523 ProQ/FINO family; Region: ProQ; smart00945 376619004524 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 376619004525 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 376619004526 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 376619004527 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 376619004528 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 376619004529 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619004530 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619004531 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619004532 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619004533 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 376619004534 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 376619004535 ring oligomerisation interface [polypeptide binding]; other site 376619004536 ATP/Mg binding site [chemical binding]; other site 376619004537 stacking interactions; other site 376619004538 hinge regions; other site 376619004539 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 376619004540 oligomerisation interface [polypeptide binding]; other site 376619004541 mobile loop; other site 376619004542 roof hairpin; other site 376619004543 Predicted membrane protein [Function unknown]; Region: COG4125 376619004544 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 376619004545 hypothetical protein; Validated; Region: PRK02101 376619004546 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619004547 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619004548 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619004549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619004550 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 376619004551 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 376619004552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 376619004553 peptide chain release factor 1; Validated; Region: prfA; PRK00591 376619004554 This domain is found in peptide chain release factors; Region: PCRF; smart00937 376619004555 RF-1 domain; Region: RF-1; pfam00472 376619004556 glutamyl-tRNA reductase; Provisional; Region: PRK13940 376619004557 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 376619004558 tRNA; other site 376619004559 putative tRNA binding site [nucleotide binding]; other site 376619004560 putative NADP binding site [chemical binding]; other site 376619004561 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 376619004562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 376619004563 TPR motif; other site 376619004564 binding surface 376619004565 Tetratricopeptide repeat; Region: TPR_16; pfam13432 376619004566 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 376619004567 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 376619004568 Trp docking motif [polypeptide binding]; other site 376619004569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004570 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 376619004571 putative substrate translocation pore; other site 376619004572 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 376619004573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 376619004574 Mg2+ binding site [ion binding]; other site 376619004575 G-X-G motif; other site 376619004576 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 376619004577 anchoring element; other site 376619004578 dimer interface [polypeptide binding]; other site 376619004579 ATP binding site [chemical binding]; other site 376619004580 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 376619004581 active site 376619004582 metal binding site [ion binding]; metal-binding site 376619004583 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 376619004584 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 376619004585 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 376619004586 amidase catalytic site [active] 376619004587 Zn binding residues [ion binding]; other site 376619004588 substrate binding site [chemical binding]; other site 376619004589 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 376619004590 active site 376619004591 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 376619004592 putative active site [active] 376619004593 Ap4A binding site [chemical binding]; other site 376619004594 nudix motif; other site 376619004595 putative metal binding site [ion binding]; other site 376619004596 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 376619004597 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 376619004598 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 376619004599 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 376619004600 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 376619004601 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 376619004602 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 376619004603 active site 376619004604 DNA binding site [nucleotide binding] 376619004605 Int/Topo IB signature motif; other site 376619004606 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 376619004607 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 376619004608 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 376619004609 RimM N-terminal domain; Region: RimM; pfam01782 376619004610 PRC-barrel domain; Region: PRC; pfam05239 376619004611 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 376619004612 S-adenosylmethionine synthetase; Validated; Region: PRK05250 376619004613 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 376619004614 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 376619004615 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 376619004616 Fatty acid desaturase; Region: FA_desaturase; pfam00487 376619004617 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 376619004618 Di-iron ligands [ion binding]; other site 376619004619 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 376619004620 UGMP family protein; Validated; Region: PRK09604 376619004621 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 376619004622 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 376619004623 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 376619004624 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 376619004625 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 376619004626 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 376619004627 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 376619004628 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 376619004629 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 376619004630 cleft; other site 376619004631 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 376619004632 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 376619004633 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 376619004634 DNA binding site [nucleotide binding] 376619004635 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 376619004636 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 376619004637 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 376619004638 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 376619004639 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 376619004640 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 376619004641 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 376619004642 RPB3 interaction site [polypeptide binding]; other site 376619004643 RPB1 interaction site [polypeptide binding]; other site 376619004644 RPB11 interaction site [polypeptide binding]; other site 376619004645 RPB10 interaction site [polypeptide binding]; other site 376619004646 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 376619004647 core dimer interface [polypeptide binding]; other site 376619004648 peripheral dimer interface [polypeptide binding]; other site 376619004649 L10 interface [polypeptide binding]; other site 376619004650 L11 interface [polypeptide binding]; other site 376619004651 putative EF-Tu interaction site [polypeptide binding]; other site 376619004652 putative EF-G interaction site [polypeptide binding]; other site 376619004653 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 376619004654 23S rRNA interface [nucleotide binding]; other site 376619004655 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 376619004656 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 376619004657 mRNA/rRNA interface [nucleotide binding]; other site 376619004658 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 376619004659 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 376619004660 23S rRNA interface [nucleotide binding]; other site 376619004661 L7/L12 interface [polypeptide binding]; other site 376619004662 putative thiostrepton binding site; other site 376619004663 L25 interface [polypeptide binding]; other site 376619004664 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 376619004665 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 376619004666 putative homodimer interface [polypeptide binding]; other site 376619004667 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 376619004668 heterodimer interface [polypeptide binding]; other site 376619004669 homodimer interface [polypeptide binding]; other site 376619004670 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 376619004671 elongation factor Tu; Reviewed; Region: PRK00049 376619004672 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 376619004673 G1 box; other site 376619004674 GEF interaction site [polypeptide binding]; other site 376619004675 GTP/Mg2+ binding site [chemical binding]; other site 376619004676 Switch I region; other site 376619004677 G2 box; other site 376619004678 G3 box; other site 376619004679 Switch II region; other site 376619004680 G4 box; other site 376619004681 G5 box; other site 376619004682 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 376619004683 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 376619004684 Antibiotic Binding Site [chemical binding]; other site 376619004685 AAA domain; Region: AAA_30; pfam13604 376619004686 Family description; Region: UvrD_C_2; pfam13538 376619004687 Mechanosensitive ion channel; Region: MS_channel; pfam00924 376619004688 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 376619004689 amphipathic channel; other site 376619004690 Asn-Pro-Ala signature motifs; other site 376619004691 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 376619004692 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619004693 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619004694 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619004695 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619004696 ATP-grasp domain; Region: ATP-grasp_4; cl17255 376619004697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 376619004698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 376619004699 dimer interface [polypeptide binding]; other site 376619004700 phosphorylation site [posttranslational modification] 376619004701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 376619004702 ATP binding site [chemical binding]; other site 376619004703 Mg2+ binding site [ion binding]; other site 376619004704 G-X-G motif; other site 376619004705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 376619004706 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 376619004707 NAD(P) binding site [chemical binding]; other site 376619004708 active site 376619004709 cytochrome oxidase bd-II, subunit I, pseudogene 376619004710 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 376619004711 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 376619004712 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 376619004713 deoxyribodipyrimidine photolyase 376619004714 hypothetical protein 376619004715 conserved hypothetical protein, pseudogene 376619004716 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 376619004717 ATP binding site [chemical binding]; other site 376619004718 Walker B motif; other site 376619004719 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 376619004720 aconitate hydratase; Validated; Region: PRK09277 376619004721 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 376619004722 substrate binding site [chemical binding]; other site 376619004723 ligand binding site [chemical binding]; other site 376619004724 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 376619004725 substrate binding site [chemical binding]; other site 376619004726 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 376619004727 Predicted membrane protein [Function unknown]; Region: COG2246 376619004728 GtrA-like protein; Region: GtrA; pfam04138 376619004729 HemN family oxidoreductase; Provisional; Region: PRK05660 376619004730 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 376619004731 FeS/SAM binding site; other site 376619004732 HemN C-terminal domain; Region: HemN_C; pfam06969 376619004733 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 376619004734 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 376619004735 hypothetical protein 376619004736 transcriptional regulator, pseudogene 376619004737 Preprotein translocase SecG subunit; Region: SecG; pfam03840 376619004738 triosephosphate isomerase; Provisional; Region: PRK14567 376619004739 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 376619004740 substrate binding site [chemical binding]; other site 376619004741 dimer interface [polypeptide binding]; other site 376619004742 catalytic triad [active] 376619004743 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 376619004744 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 376619004745 active site 376619004746 substrate binding site [chemical binding]; other site 376619004747 metal binding site [ion binding]; metal-binding site 376619004748 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 376619004749 active site 376619004750 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 376619004751 E3 interaction surface; other site 376619004752 lipoyl attachment site [posttranslational modification]; other site 376619004753 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 376619004754 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 376619004755 E3 interaction surface; other site 376619004756 lipoyl attachment site [posttranslational modification]; other site 376619004757 e3 binding domain; Region: E3_binding; pfam02817 376619004758 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 376619004759 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 376619004760 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 376619004761 TPP-binding site [chemical binding]; other site 376619004762 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 376619004763 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 376619004764 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 376619004765 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 376619004766 L-aspartate oxidase; Provisional; Region: PRK06175 376619004767 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 376619004768 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 376619004769 SdhC subunit interface [polypeptide binding]; other site 376619004770 proximal heme binding site [chemical binding]; other site 376619004771 cardiolipin binding site; other site 376619004772 Iron-sulfur protein interface; other site 376619004773 proximal quinone binding site [chemical binding]; other site 376619004774 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 376619004775 Iron-sulfur protein interface; other site 376619004776 proximal quinone binding site [chemical binding]; other site 376619004777 SdhD (CybS) interface [polypeptide binding]; other site 376619004778 proximal heme binding site [chemical binding]; other site 376619004779 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 376619004780 dimer interface [polypeptide binding]; other site 376619004781 Citrate synthase; Region: Citrate_synt; pfam00285 376619004782 active site 376619004783 citrylCoA binding site [chemical binding]; other site 376619004784 NADH binding [chemical binding]; other site 376619004785 cationic pore residues; other site 376619004786 oxalacetate/citrate binding site [chemical binding]; other site 376619004787 coenzyme A binding site [chemical binding]; other site 376619004788 catalytic triad [active] 376619004789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004790 muropeptide transporter; Reviewed; Region: ampG; PRK11902 376619004791 putative substrate translocation pore; other site 376619004792 superoxide dismutase; Provisional; Region: PRK10543 376619004793 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 376619004794 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 376619004795 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 376619004796 putative GSH binding site [chemical binding]; other site 376619004797 catalytic residues [active] 376619004798 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 376619004799 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 376619004800 putative active site [active] 376619004801 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 376619004802 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 376619004803 gamma subunit interface [polypeptide binding]; other site 376619004804 epsilon subunit interface [polypeptide binding]; other site 376619004805 LBP interface [polypeptide binding]; other site 376619004806 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 376619004807 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 376619004808 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 376619004809 alpha subunit interaction interface [polypeptide binding]; other site 376619004810 Walker A motif; other site 376619004811 ATP binding site [chemical binding]; other site 376619004812 Walker B motif; other site 376619004813 inhibitor binding site; inhibition site 376619004814 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 376619004815 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 376619004816 core domain interface [polypeptide binding]; other site 376619004817 delta subunit interface [polypeptide binding]; other site 376619004818 epsilon subunit interface [polypeptide binding]; other site 376619004819 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 376619004820 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 376619004821 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 376619004822 beta subunit interaction interface [polypeptide binding]; other site 376619004823 Walker A motif; other site 376619004824 ATP binding site [chemical binding]; other site 376619004825 Walker B motif; other site 376619004826 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 376619004827 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 376619004828 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 376619004829 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 376619004830 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 376619004831 F0F1 ATP synthase subunit C; Provisional; Region: PRK13464 376619004832 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 376619004833 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 376619004834 Major Facilitator Superfamily; Region: MFS_1; pfam07690 376619004835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004836 putative substrate translocation pore; other site 376619004837 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 376619004838 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 376619004839 RNA binding surface [nucleotide binding]; other site 376619004840 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 376619004841 active site 376619004842 Predicted ATPase [General function prediction only]; Region: COG1485 376619004843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004844 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 376619004845 putative substrate translocation pore; other site 376619004846 histidyl-tRNA synthetase; Region: hisS; TIGR00442 376619004847 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 376619004848 dimer interface [polypeptide binding]; other site 376619004849 motif 1; other site 376619004850 active site 376619004851 motif 2; other site 376619004852 motif 3; other site 376619004853 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 376619004854 anticodon binding site; other site 376619004855 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 376619004856 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 376619004857 translation initiation factor IF-2; Region: IF-2; TIGR00487 376619004858 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 376619004859 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 376619004860 G1 box; other site 376619004861 putative GEF interaction site [polypeptide binding]; other site 376619004862 GTP/Mg2+ binding site [chemical binding]; other site 376619004863 Switch I region; other site 376619004864 G2 box; other site 376619004865 G3 box; other site 376619004866 Switch II region; other site 376619004867 G4 box; other site 376619004868 G5 box; other site 376619004869 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 376619004870 Translation-initiation factor 2; Region: IF-2; pfam11987 376619004871 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 376619004872 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 376619004873 NusA N-terminal domain; Region: NusA_N; pfam08529 376619004874 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 376619004875 RNA binding site [nucleotide binding]; other site 376619004876 homodimer interface [polypeptide binding]; other site 376619004877 NusA-like KH domain; Region: KH_5; pfam13184 376619004878 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 376619004879 G-X-X-G motif; other site 376619004880 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 376619004881 ribosome maturation protein RimP; Reviewed; Region: PRK00092 376619004882 hypothetical protein; Provisional; Region: PRK14641 376619004883 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 376619004884 putative oligomer interface [polypeptide binding]; other site 376619004885 putative RNA binding site [nucleotide binding]; other site 376619004886 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 376619004887 substrate binding site [chemical binding]; other site 376619004888 active site 376619004889 ComM-related protein 376619004890 chelatase family protein, pseudogene 376619004891 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619004892 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619004893 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619004894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619004895 conserved hypothetical protein 376619004896 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 376619004897 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 376619004898 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 376619004899 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 376619004900 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 376619004901 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 376619004902 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 376619004903 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 376619004904 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 376619004905 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 376619004906 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 376619004907 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 376619004908 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 376619004909 NADH dehydrogenase subunit G; Validated; Region: PRK09129 376619004910 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 376619004911 catalytic loop [active] 376619004912 iron binding site [ion binding]; other site 376619004913 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 376619004914 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 376619004915 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 376619004916 SLBB domain; Region: SLBB; pfam10531 376619004917 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 376619004918 NADH dehydrogenase subunit E; Validated; Region: PRK07539 376619004919 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 376619004920 putative dimer interface [polypeptide binding]; other site 376619004921 [2Fe-2S] cluster binding site [ion binding]; other site 376619004922 NADH dehydrogenase subunit D; Validated; Region: PRK06075 376619004923 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 376619004924 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 376619004925 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 376619004926 NADH dehydrogenase subunit B; Validated; Region: PRK06411 376619004927 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 376619004928 ferric uptake regulator; Provisional; Region: fur; PRK09462 376619004929 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 376619004930 metal binding site 2 [ion binding]; metal-binding site 376619004931 putative DNA binding helix; other site 376619004932 metal binding site 1 [ion binding]; metal-binding site 376619004933 dimer interface [polypeptide binding]; other site 376619004934 structural Zn2+ binding site [ion binding]; other site 376619004935 IucA / IucC family; Region: IucA_IucC; pfam04183 376619004936 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 376619004937 Major Facilitator Superfamily; Region: MFS_1; pfam07690 376619004938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004939 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 376619004940 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 376619004941 dimer interface [polypeptide binding]; other site 376619004942 active site 376619004943 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 376619004944 catalytic residues [active] 376619004945 substrate binding site [chemical binding]; other site 376619004946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619004947 putative substrate translocation pore; other site 376619004948 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 376619004949 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 376619004950 oxyanion hole [active] 376619004951 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 376619004952 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 376619004953 catalytic triad [active] 376619004954 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 376619004955 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 376619004956 GatB domain; Region: GatB_Yqey; smart00845 376619004957 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 376619004958 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 376619004959 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 376619004960 HlyD family secretion protein; Region: HlyD_3; pfam13437 376619004961 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 376619004962 adenylosuccinate lyase; Provisional; Region: PRK07492 376619004963 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 376619004964 tetramer interface [polypeptide binding]; other site 376619004965 active site 376619004966 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619004967 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619004968 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619004969 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 376619004970 active site 376619004971 catalytic residues [active] 376619004972 restriction endonuclease, pseudogene 376619004973 hypothetical protein 376619004974 modification methylase, fragment 376619004975 hypothetical protein 376619004976 modification methylase, pseudogene 376619004977 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 376619004978 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 376619004979 dimerization interface [polypeptide binding]; other site 376619004980 ATP binding site [chemical binding]; other site 376619004981 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 376619004982 dimerization interface [polypeptide binding]; other site 376619004983 ATP binding site [chemical binding]; other site 376619004984 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 376619004985 putative active site [active] 376619004986 catalytic triad [active] 376619004987 amidophosphoribosyltransferase; Provisional; Region: PRK09246 376619004988 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 376619004989 active site 376619004990 tetramer interface [polypeptide binding]; other site 376619004991 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 376619004992 active site 376619004993 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 376619004994 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 376619004995 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 376619004996 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 376619004997 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 376619004998 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 376619004999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 376619005000 putative protease; Provisional; Region: PRK15452 376619005001 Peptidase family U32; Region: Peptidase_U32; pfam01136 376619005002 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 376619005003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619005004 putative substrate translocation pore; other site 376619005005 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 376619005006 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 376619005007 putative ABC transporter ATP-binding protein 376619005008 ABC transporter, ATP-binding protein,pseudogene 376619005009 ABC-type uncharacterized transport system permease 376619005010 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 376619005011 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 376619005012 GTP1/OBG; Region: GTP1_OBG; pfam01018 376619005013 Obg GTPase; Region: Obg; cd01898 376619005014 G1 box; other site 376619005015 GTP/Mg2+ binding site [chemical binding]; other site 376619005016 Switch I region; other site 376619005017 G2 box; other site 376619005018 G3 box; other site 376619005019 Switch II region; other site 376619005020 G4 box; other site 376619005021 G5 box; other site 376619005022 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 376619005023 aromatic amino acid transport protein; Region: araaP; TIGR00837 376619005024 transcriptional regulatory protein, pseudogene 376619005025 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 376619005026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 376619005027 dimer interface [polypeptide binding]; other site 376619005028 phosphorylation site [posttranslational modification] 376619005029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 376619005030 ATP binding site [chemical binding]; other site 376619005031 Mg2+ binding site [ion binding]; other site 376619005032 G-X-G motif; other site 376619005033 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 376619005034 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 376619005035 Ligand Binding Site [chemical binding]; other site 376619005036 K+-transporting ATPase, c chain; Region: KdpC; cl00944 376619005037 Soluble P-type ATPase [General function prediction only]; Region: COG4087 376619005038 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 376619005039 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 376619005040 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 376619005041 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 376619005042 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619005043 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619005044 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 376619005045 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619005046 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619005047 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619005048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619005049 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 376619005050 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 376619005051 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 376619005052 substrate binding site [chemical binding]; other site 376619005053 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 376619005054 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 376619005055 substrate binding site [chemical binding]; other site 376619005056 ligand binding site [chemical binding]; other site 376619005057 hypothetical protein 376619005058 Transposase; Region: HTH_Tnp_IS630; pfam01710 376619005059 Helix-turn-helix domain; Region: HTH_28; pfam13518 376619005060 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619005061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619005062 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 376619005063 hypothetical protein 376619005064 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619005065 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 376619005066 hypothetical protein 376619005067 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 376619005068 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 376619005069 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 376619005070 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 376619005071 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 376619005072 glutamine synthetase; Region: PLN02284 376619005073 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 376619005074 Eps15 homology domain; Region: EH; smart00027 376619005075 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 376619005076 Glutaminase; Region: Glutaminase; cl00907 376619005077 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 376619005078 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 376619005079 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 376619005080 hypothetical protein; Provisional; Region: PRK05208 376619005081 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 376619005082 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 376619005083 dimer interface [polypeptide binding]; other site 376619005084 putative anticodon binding site; other site 376619005085 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 376619005086 motif 1; other site 376619005087 active site 376619005088 motif 2; other site 376619005089 motif 3; other site 376619005090 This domain is found in peptide chain release factors; Region: PCRF; smart00937 376619005091 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 376619005092 RF-1 domain; Region: RF-1; pfam00472 376619005093 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 376619005094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 376619005095 Walker A motif; other site 376619005096 ATP binding site [chemical binding]; other site 376619005097 Walker B motif; other site 376619005098 DNA polymerase III subunit delta'; Validated; Region: PRK08485 376619005099 arginine finger; other site 376619005100 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 376619005101 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 376619005102 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 376619005103 cell division protein FtsZ; Validated; Region: PRK09330 376619005104 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 376619005105 nucleotide binding site [chemical binding]; other site 376619005106 SulA interaction site; other site 376619005107 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 376619005108 Cell division protein FtsA; Region: FtsA; smart00842 376619005109 Cell division protein FtsA; Region: FtsA; pfam14450 376619005110 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 376619005111 Cell division protein FtsQ; Region: FtsQ; pfam03799 376619005112 D-alanyl-alanine synthetase A; Provisional; Region: PRK14569 376619005113 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 376619005114 ATP-grasp domain; Region: ATP-grasp_4; cl17255 376619005115 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 376619005116 nucleoside/Zn binding site; other site 376619005117 dimer interface [polypeptide binding]; other site 376619005118 catalytic motif [active] 376619005119 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 376619005120 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 376619005121 RNA binding site [nucleotide binding]; other site 376619005122 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 376619005123 RNA binding site [nucleotide binding]; other site 376619005124 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 376619005125 RNA binding site [nucleotide binding]; other site 376619005126 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 376619005127 RNA binding site [nucleotide binding]; other site 376619005128 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 376619005129 RNA binding site [nucleotide binding]; other site 376619005130 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 376619005131 RNA binding site [nucleotide binding]; other site 376619005132 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 376619005133 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 376619005134 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 376619005135 putative acyl-acceptor binding pocket; other site 376619005136 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 376619005137 Competence protein; Region: Competence; pfam03772 376619005138 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 376619005139 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 376619005140 ATP-grasp domain; Region: ATP-grasp_4; cl17255 376619005141 ABC transporter, membrane protein, pseudogene 376619005142 nitrate ABC transporter, permease protein 376619005143 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 376619005144 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 376619005145 Walker A/P-loop; other site 376619005146 ATP binding site [chemical binding]; other site 376619005147 Q-loop/lid; other site 376619005148 ABC transporter signature motif; other site 376619005149 Walker B; other site 376619005150 D-loop; other site 376619005151 H-loop/switch region; other site 376619005152 YGGT family; Region: YGGT; pfam02325 376619005153 YGGT family; Region: YGGT; pfam02325 376619005154 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 376619005155 putative active site [active] 376619005156 Zn binding site [ion binding]; other site 376619005157 hypothetical membrane protein, fragment 376619005158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 376619005159 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619005160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619005161 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 376619005162 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 376619005163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 376619005164 hypothetical protein 376619005165 Transporter protein, pseudogene 376619005166 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 376619005167 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 376619005168 purine monophosphate binding site [chemical binding]; other site 376619005169 dimer interface [polypeptide binding]; other site 376619005170 putative catalytic residues [active] 376619005171 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 376619005172 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 376619005173 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 376619005174 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 376619005175 GDP-binding site [chemical binding]; other site 376619005176 ACT binding site; other site 376619005177 IMP binding site; other site 376619005178 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 376619005179 active site 376619005180 dienelactone hydrolase family protein 376619005181 dienelactone hydrolase family protein,pseudogene 376619005182 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 376619005183 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 376619005184 dimer interface [polypeptide binding]; other site 376619005185 putative PBP binding regions; other site 376619005186 ABC-ATPase subunit interface; other site 376619005187 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 376619005188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 376619005189 Walker A/P-loop; other site 376619005190 ATP binding site [chemical binding]; other site 376619005191 Q-loop/lid; other site 376619005192 ABC transporter signature motif; other site 376619005193 Walker B; other site 376619005194 D-loop; other site 376619005195 H-loop/switch region; other site 376619005196 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 376619005197 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 376619005198 intersubunit interface [polypeptide binding]; other site 376619005199 hypothetical protein 376619005200 major facilitator superfamily (MFS) transport protein, pseudogene 376619005201 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 376619005202 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 376619005203 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 376619005204 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 376619005205 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 376619005206 primosome assembly protein PriA; Validated; Region: PRK05580 376619005207 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 376619005208 ATP binding site [chemical binding]; other site 376619005209 putative Mg++ binding site [ion binding]; other site 376619005210 helicase superfamily c-terminal domain; Region: HELICc; smart00490 376619005211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 376619005212 DDE superfamily endonuclease; Region: DDE_3; pfam13358 376619005213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 376619005214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 376619005215 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 376619005216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 376619005217 Walker A/P-loop; other site 376619005218 ATP binding site [chemical binding]; other site 376619005219 Q-loop/lid; other site 376619005220 ABC transporter signature motif; other site 376619005221 Walker B; other site 376619005222 D-loop; other site 376619005223 H-loop/switch region; other site 376619005224 ABC transporter; Region: ABC_tran_2; pfam12848 376619005225 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 376619005226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 376619005227 metabolite-proton symporter; Region: 2A0106; TIGR00883 376619005228 putative substrate translocation pore; other site 376619005229 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 376619005230 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 376619005231 LysE type translocator; Region: LysE; cl00565 376619005232 replication initiation inhibitor 376619005233 chromosome initiation inhibitor, pseudogene 376619005234 Transposase, pseudogene 376619005235 aminopeptidase N; Provisional; Region: pepN; PRK14015 376619005236 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 376619005237 active site 376619005238 Zn binding site [ion binding]; other site 376619005239 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 376619005240 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 376619005241 putative dimer interface [polypeptide binding]; other site 376619005242 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 376619005243 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 376619005244 active site 376619005245 ribulose/triose binding site [chemical binding]; other site 376619005246 phosphate binding site [ion binding]; other site 376619005247 substrate (anthranilate) binding pocket [chemical binding]; other site 376619005248 product (indole) binding pocket [chemical binding]; other site 376619005249 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 376619005250 active site 376619005251 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 376619005252 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 376619005253 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 376619005254 anthranilate synthase component II, pseudogene 376619005255 glutamine amidotransferase of anthranilate synthase 376619005256 anthranilate synthase component I; Provisional; Region: PRK13564 376619005257 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 376619005258 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 376619005259 Trp repressor protein; Region: Trp_repressor; cl17266 376619005260 ribonuclease G; Provisional; Region: PRK11712 376619005261 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 376619005262 homodimer interface [polypeptide binding]; other site 376619005263 oligonucleotide binding site [chemical binding]; other site