-- dump date 20140619_095357 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_762705.1 115313982 4307671 1..1476 1 NC_008369.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1476 dnaA 4307671 dnaA Francisella tularensis subsp. holarctica OSU18 chromosomal replication initiation protein YP_762705.1 1 D 393011 CDS YP_762706.1 115313983 4307672 1513..2616 1 NC_008369.1 DNA nucleotidyltransferase (DNA-directed); DNA-directed DNA polymerase 2616 dnaN 4307672 dnaN Francisella tularensis subsp. holarctica OSU18 DNA-directed DNA polymerase YP_762706.1 1513 D 393011 CDS YP_762707.1 115313984 4307674 complement(join(3062..3613,3613..3942)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1; ISFtu1 transposase 3942 isftu1 4307674 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_762707.1 3062 R 393011 CDS YP_762708.1 115313985 4307675 3933..4670 1 NC_008369.1 CPA1 family monovalent cation:proton (H+) antiporter-1 4670 4307675 FTH_0005 Francisella tularensis subsp. holarctica OSU18 CPA1 family monovalent cation:proton (H+) antiporter-1 YP_762708.1 3933 D 393011 CDS YP_762709.1 115313986 4307678 6907..7830 1 NC_008369.1 possble periplasmic serine protease; protease 7830 4307678 FTH_0008 Francisella tularensis subsp. holarctica OSU18 protease YP_762709.1 6907 D 393011 CDS YP_762710.1 115313987 4307679 7884..8459 1 NC_008369.1 outer membrane protein OmpH 8459 4307679 FTH_0009 Francisella tularensis subsp. holarctica OSU18 outer membrane protein OmpH YP_762710.1 7884 D 393011 CDS YP_762711.1 115313988 4307680 8595..9017 1 NC_008369.1 sulfur transferase 9017 4307680 FTH_0010 Francisella tularensis subsp. holarctica OSU18 sulfur transferase YP_762711.1 8595 D 393011 CDS YP_762712.1 115313989 4307681 9045..9494 1 NC_008369.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 9494 secB1 4307681 secB1 Francisella tularensis subsp. holarctica OSU18 preprotein translocase subunit SecB YP_762712.1 9045 D 393011 CDS YP_762713.1 115313990 4307682 9516..10595 1 NC_008369.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 10595 recA 4307682 recA Francisella tularensis subsp. holarctica OSU18 recombinase A YP_762713.1 9516 D 393011 CDS YP_762714.1 115313991 4307683 10582..11034 1 NC_008369.1 OraA/RecX protein 11034 4307683 FTH_0013 Francisella tularensis subsp. holarctica OSU18 OraA/RecX protein YP_762714.1 10582 D 393011 CDS YP_762715.1 115313992 4307684 11207..11683 1 NC_008369.1 single-stranded DNA binding protein 11683 ssb 4307684 ssb Francisella tularensis subsp. holarctica OSU18 single-stranded DNA binding protein YP_762715.1 11207 D 393011 CDS YP_762716.1 115313993 4307685 11789..12946 1 NC_008369.1 acetate kinase 12946 ackA 4307685 ackA Francisella tularensis subsp. holarctica OSU18 acetate kinase YP_762716.1 11789 D 393011 CDS YP_762717.1 115313994 4307686 12956..15052 1 NC_008369.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 15052 pta 4307686 pta Francisella tularensis subsp. holarctica OSU18 phosphate acetyltransferase YP_762717.1 12956 D 393011 CDS YP_762718.1 115313995 4307688 complement(join(15937..16488,16488..16817)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 16817 isftu1 4307688 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_762718.1 15937 R 393011 CDS YP_762719.1 115313996 4307690 complement(17312..19084) 1 NC_008369.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 19084 aspS 4307690 aspS Francisella tularensis subsp. holarctica OSU18 aspartyl-tRNA synthetase YP_762719.1 17312 R 393011 CDS YP_762720.1 115313997 4307691 complement(19258..20439) 1 NC_008369.1 major facilitator transporter 20439 4307691 FTH_0021 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_762720.1 19258 R 393011 CDS YP_762721.1 115313998 4307695 complement(22907..24109) 1 NC_008369.1 HAAAP family serine/threonine permease 24109 4307695 FTH_0024 Francisella tularensis subsp. holarctica OSU18 HAAAP family serine/threonine permease YP_762721.1 22907 R 393011 CDS YP_762722.1 115313999 4307696 complement(24457..24690) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 24690 4307696 FTH_0025 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762722.1 24457 R 393011 CDS YP_762723.1 115314000 4307698 complement(26074..26994) 1 NC_008369.1 aspartate transcarbamylase; aspartate carbamoyltransferase 26994 pyrB 4307698 pyrB Francisella tularensis subsp. holarctica OSU18 aspartate carbamoyltransferase YP_762723.1 26074 R 393011 CDS YP_762724.1 115314001 4307699 complement(27136..30423) 1 NC_008369.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 30423 carB 4307699 carB Francisella tularensis subsp. holarctica OSU18 carbamoyl phosphate synthase large subunit YP_762724.1 27136 R 393011 CDS YP_762725.1 115314002 4307700 complement(30428..31594) 1 NC_008369.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 31594 carA 4307700 carA Francisella tularensis subsp. holarctica OSU18 carbamoyl phosphate synthase small subunit YP_762725.1 30428 R 393011 CDS YP_762726.1 115314003 4307701 32011..33066 1 NC_008369.1 acid phosphomonoesterase; acid phosphatase 33066 4307701 FTH_0030 Francisella tularensis subsp. holarctica OSU18 acid phosphatase YP_762726.1 32011 D 393011 CDS YP_762727.1 115314004 4307702 complement(33190..33870) 1 NC_008369.1 catalyzes the S-adenosylmethionine-dependent transmethylation of thiopurine compounds; may be involved in selenium cycling by forming dimethylselenide and/or dimethyldiselenide; thiopurine S-methyltransferase 33870 tpmT 4307702 tpmT Francisella tularensis subsp. holarctica OSU18 thiopurine S-methyltransferase YP_762727.1 33190 R 393011 CDS YP_762728.1 115314005 4307703 34002..35348 1 NC_008369.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; dihydroorotase 35348 pyrC 4307703 pyrC Francisella tularensis subsp. holarctica OSU18 dihydroorotase YP_762728.1 34002 D 393011 CDS YP_762729.1 115314006 4307704 complement(35376..36416) 1 NC_008369.1 hypothetical protein 36416 4307704 FTH_0033 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762729.1 35376 R 393011 CDS YP_762730.1 115314007 4307706 36953..37231 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 37231 4307706 FTH_0035 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762730.1 36953 D 393011 CDS YP_762731.1 115314008 4307707 37620..38171 1 NC_008369.1 hypothetical protein 38171 4307707 FTH_0036 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762731.1 37620 D 393011 CDS YP_762732.1 115314009 4307708 complement(38287..39351) 1 NC_008369.1 hypothetical protein 39351 4307708 FTH_0037 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762732.1 38287 R 393011 CDS YP_762733.1 115314010 4307709 complement(39326..40291) 1 NC_008369.1 HlyD family secretion protein 40291 4307709 FTH_0038 Francisella tularensis subsp. holarctica OSU18 HlyD family secretion protein YP_762733.1 39326 R 393011 CDS YP_762734.1 115314011 4307710 complement(40380..40787) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 40787 4307710 FTH_0039 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762734.1 40380 R 393011 CDS YP_762735.1 115314012 4307711 40913..41782 1 NC_008369.1 LysR family transcriptional regulator 41782 lysR 4307711 lysR Francisella tularensis subsp. holarctica OSU18 LysR family transcriptional regulator YP_762735.1 40913 D 393011 CDS YP_762736.1 115314013 4307714 43410..43958 1 NC_008369.1 chorismate mutase 43958 4307714 FTH_0043 Francisella tularensis subsp. holarctica OSU18 chorismate mutase YP_762736.1 43410 D 393011 CDS YP_762737.1 115314014 4307715 complement(44013..47387) 1 NC_008369.1 transglutaminase 47387 4307715 FTH_0044 Francisella tularensis subsp. holarctica OSU18 transglutaminase YP_762737.1 44013 R 393011 CDS YP_762738.1 115314015 4307716 47654..48298 1 NC_008369.1 OMP decarboxylase; orotidine-5'-phosphate decarboxylase 48298 pyrF 4307716 pyrF Francisella tularensis subsp. holarctica OSU18 orotidine-5'-phosphate decarboxylase YP_762738.1 47654 D 393011 CDS YP_762739.1 115314016 4307186 48288..49046 1 NC_008369.1 DHOdehase; dihydroorotate oxidase 49046 pyrD 4307186 pyrD Francisella tularensis subsp. holarctica OSU18 dihydroorotate oxidase YP_762739.1 48288 D 393011 CDS YP_762740.1 115314017 4307187 complement(49410..49580) 1 NC_008369.1 hypothetical protein 49580 4307187 FTH_0047 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762740.1 49410 R 393011 CDS YP_762741.1 115314018 4307188 complement(49584..50246) 1 NC_008369.1 hydroxyphenylpyruvate synthase; prephenate dehydrogenase 50246 tyrA 4307188 tyrA Francisella tularensis subsp. holarctica OSU18 prephenate dehydrogenase YP_762741.1 49584 R 393011 CDS YP_762742.1 115314019 4307189 complement(50514..50951) 1 NC_008369.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 50951 dtd 4307189 dtd Francisella tularensis subsp. holarctica OSU18 D-tyrosyl-tRNA(Tyr) deacylase YP_762742.1 50514 R 393011 CDS YP_762743.1 115314020 4307192 complement(join(54129..54680,54680..55009)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1; ISFtu1 transposase 55009 isftu1 4307192 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_762743.1 54129 R 393011 CDS YP_762744.1 115314021 4307193 complement(55033..55584) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 55584 4307193 FTH_0053 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762744.1 55033 R 393011 CDS YP_762745.1 115314022 4307194 complement(55855..56520) 1 NC_008369.1 nitroreductase 56520 4307194 FTH_0054 Francisella tularensis subsp. holarctica OSU18 nitroreductase YP_762745.1 55855 R 393011 CDS YP_762746.1 115314023 4307195 56745..56864 1 NC_008369.1 hypothetical protein 56864 4307195 FTH_0055 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762746.1 56745 D 393011 CDS YP_762747.1 115314024 4307196 56923..57615 1 NC_008369.1 hypothetical protein 57615 4307196 FTH_0056 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762747.1 56923 D 393011 CDS YP_762748.1 115314025 4307197 complement(57612..58817) 1 NC_008369.1 HAAAP family aromatic amino acid transporter 58817 4307197 FTH_0057 Francisella tularensis subsp. holarctica OSU18 HAAAP family aromatic amino acid transporter YP_762748.1 57612 R 393011 CDS YP_762749.1 115314026 4307198 58917..59534 1 NC_008369.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 59534 gidB 4307198 gidB Francisella tularensis subsp. holarctica OSU18 16S rRNA methyltransferase GidB YP_762749.1 58917 D 393011 CDS YP_762750.1 115314027 4307199 59531..60199 1 NC_008369.1 hypothetical protein 60199 4307199 FTH_0059 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762750.1 59531 D 393011 CDS YP_762751.1 115314028 4307200 complement(60192..61076) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 61076 4307200 FTH_0060 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762751.1 60192 R 393011 CDS YP_762752.1 115314029 4307202 62277..63413 1 NC_008369.1 major facilitator transporter 63413 4307202 FTH_0062 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_762752.1 62277 D 393011 CDS YP_762753.1 115314030 4307204 65894..66490 1 NC_008369.1 phosphoheptose isomerase 66490 gmhA 4307204 gmhA Francisella tularensis subsp. holarctica OSU18 phosphoheptose isomerase YP_762753.1 65894 D 393011 CDS YP_762754.1 115314031 4307205 66498..66854 1 NC_008369.1 outer membrane lipoprotein 66854 omlA 4307205 omlA Francisella tularensis subsp. holarctica OSU18 outer membrane lipoprotein YP_762754.1 66498 D 393011 CDS YP_762755.1 115314032 4307206 complement(66928..67200) 1 NC_008369.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 67200 rpsT 4307206 rpsT Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S20 YP_762755.1 66928 R 393011 CDS YP_762756.1 115314033 4307207 67470..69254 1 NC_008369.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 69254 lepA 4307207 lepA Francisella tularensis subsp. holarctica OSU18 GTP-binding protein LepA YP_762756.1 67470 D 393011 CDS YP_762757.1 115314034 4307208 69202..70347 1 NC_008369.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 70347 mnmA 4307208 mnmA Francisella tularensis subsp. holarctica OSU18 tRNA-specific 2-thiouridylase MnmA YP_762757.1 69202 D 393011 CDS YP_762758.1 115314035 4307209 complement(70367..71347) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 71347 4307209 FTH_0069 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762758.1 70367 R 393011 CDS YP_762759.1 115314036 4307210 complement(71441..71959) 1 NC_008369.1 PDF; peptide deformylase 71959 def 4307210 def Francisella tularensis subsp. holarctica OSU18 peptide deformylase YP_762759.1 71441 R 393011 CDS YP_762760.1 115314037 4307211 complement(71962..72405) 1 NC_008369.1 riboflavin synthase beta subunit 72405 ribH 4307211 ribH Francisella tularensis subsp. holarctica OSU18 riboflavin synthase beta subunit YP_762760.1 71962 R 393011 CDS YP_762761.1 115314038 4307212 complement(72415..73626) 1 NC_008369.1 riboflavin biosynthesis protein; GTP-cyclohydrolase II 73626 ribA 4307212 ribA Francisella tularensis subsp. holarctica OSU18 GTP-cyclohydrolase II YP_762761.1 72415 R 393011 CDS YP_762762.1 115314039 4307213 complement(73619..74224) 1 NC_008369.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 74224 ribB 4307213 ribB Francisella tularensis subsp. holarctica OSU18 riboflavin synthase subunit alpha YP_762762.1 73619 R 393011 CDS YP_762763.1 115314040 4307214 complement(74217..75284) 1 NC_008369.1 bifunctional riboflavin-specific deaminase and HTP reductase; bifunctional 5-amino-6-(5-phosphoribosylamino)uracil reductase/ diaminohydroxyphosphoribosylaminopyrimidine deaminase 75284 ribD 4307214 ribD Francisella tularensis subsp. holarctica OSU18 bifunctional 5-amino-6-(5-phosphoribosylamino)uracil reductase/ diaminohydroxyphosphoribosylaminopyrimidine deaminase YP_762763.1 74217 R 393011 CDS YP_762764.1 115314041 4307218 complement(78255..78848) 1 NC_008369.1 cytochrome b561 78848 cybB 4307218 cybB Francisella tularensis subsp. holarctica OSU18 cytochrome b561 YP_762764.1 78255 R 393011 CDS YP_762765.1 115314042 4307220 79820..80971 1 NC_008369.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 80971 nhaA 4307220 nhaA Francisella tularensis subsp. holarctica OSU18 pH-dependent sodium/proton antiporter YP_762765.1 79820 D 393011 CDS YP_762766.1 115314043 4307221 81036..81755 1 NC_008369.1 hypothetical protein 81755 4307221 FTH_0081 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762766.1 81036 D 393011 CDS YP_762767.1 115314044 4307222 complement(81761..82501) 1 NC_008369.1 acyltransferase 82501 4307222 FTH_0082 Francisella tularensis subsp. holarctica OSU18 acyltransferase YP_762767.1 81761 R 393011 CDS YP_762768.1 115314045 4307223 complement(82515..83267) 1 NC_008369.1 acyltransferase 83267 4307223 FTH_0083 Francisella tularensis subsp. holarctica OSU18 acyltransferase YP_762768.1 82515 R 393011 CDS YP_762769.1 115314046 4307224 complement(83430..83753) 1 NC_008369.1 ferredoxin 83753 4307224 FTH_0084 Francisella tularensis subsp. holarctica OSU18 ferredoxin YP_762769.1 83430 R 393011 CDS YP_762770.1 115314047 4307225 83984..84625 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 84625 4307225 FTH_0085 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762770.1 83984 D 393011 CDS YP_762771.1 115314048 4307227 complement(85358..86518) 1 NC_008369.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 86518 purT 4307227 purT Francisella tularensis subsp. holarctica OSU18 phosphoribosylglycinamide formyltransferase 2 YP_762771.1 85358 R 393011 CDS YP_762772.1 115314049 4307228 complement(86572..88764) 1 NC_008369.1 1,4-beta-poly-N-acetylglucosaminidase; chitinase 88764 4307228 FTH_0088 Francisella tularensis subsp. holarctica OSU18 chitinase YP_762772.1 86572 R 393011 CDS YP_762773.1 115314050 4307229 complement(89015..91594) 1 NC_008369.1 caseinolytic protease; endopeptidase Clp 91594 clpB 4307229 clpB Francisella tularensis subsp. holarctica OSU18 endopeptidase Clp YP_762773.1 89015 R 393011 CDS YP_762774.1 115314051 4307231 92540..92893 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 92893 4307231 FTH_0091 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762774.1 92540 D 393011 CDS YP_762775.1 115314052 4307232 complement(92948..93757) 1 NC_008369.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 93757 trpA 4307232 trpA Francisella tularensis subsp. holarctica OSU18 tryptophan synthase subunit alpha YP_762775.1 92948 R 393011 CDS YP_762776.1 115314053 4307233 complement(93757..94947) 1 NC_008369.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 94947 trpB 4307233 trpB Francisella tularensis subsp. holarctica OSU18 tryptophan synthase subunit beta YP_762776.1 93757 R 393011 CDS YP_762777.1 115314054 4307234 complement(95034..96539) 1 NC_008369.1 carboxypeptidase 96539 4307234 FTH_0094 Francisella tularensis subsp. holarctica OSU18 carboxypeptidase YP_762777.1 95034 R 393011 CDS YP_762778.1 115314055 4307235 complement(96475..97893) 1 NC_008369.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 97893 4307235 FTH_0095 Francisella tularensis subsp. holarctica OSU18 chloride channel protein YP_762778.1 96475 R 393011 CDS YP_762779.1 115314056 4307237 complement(98364..98774) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 98774 4307237 FTH_0097 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762779.1 98364 R 393011 CDS YP_762780.1 115314057 4307238 complement(98795..99187) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 99187 4307238 FTH_0098 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762780.1 98795 R 393011 CDS YP_762781.1 115314058 4307240 join(99988..100317,100317..100868) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 100868 isftu1 4307240 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_762781.1 99988 D 393011 CDS YP_762782.1 115314059 4307243 102493..103083 1 NC_008369.1 IglA2; intracellular growth locus A protein 103083 iglA2 4307243 iglA2 Francisella tularensis subsp. holarctica OSU18 intracellular growth locus A protein YP_762782.1 102493 D 393011 CDS YP_762783.1 115314060 4307244 103073..104617 1 NC_008369.1 IglB2; intracellular growth locus B protein 104617 iglB2 4307244 iglB2 Francisella tularensis subsp. holarctica OSU18 intracellular growth locus B protein YP_762783.1 103073 D 393011 CDS YP_762784.1 115314061 4307245 104628..105263 1 NC_008369.1 IglC2; intracellular growth locus C protein 105263 iglC2 4307245 iglC2 Francisella tularensis subsp. holarctica OSU18 intracellular growth locus C protein YP_762784.1 104628 D 393011 CDS YP_762785.1 115314062 4307246 105284..106480 1 NC_008369.1 IglD2; intracellular growth locus D protein 106480 iglD2 4307246 iglD2 Francisella tularensis subsp. holarctica OSU18 intracellular growth locus D protein YP_762785.1 105284 D 393011 CDS YP_762786.1 115314063 4307247 complement(106487..107062) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 107062 4307247 FTH_0107 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762786.1 106487 R 393011 CDS YP_762787.1 115314064 4307248 complement(107080..111066) 1 NC_008369.1 PdpC2; conserved in Francisella genomes; protein PdpC 111066 pdpC2 4307248 pdpC2 Francisella tularensis subsp. holarctica OSU18 protein PdpC YP_762787.1 107080 R 393011 CDS YP_762788.1 115314065 4307249 complement(111106..111879) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 111879 4307249 FTH_0109 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762788.1 111106 R 393011 CDS YP_762789.1 115314066 4307250 complement(111845..112996) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 112996 4307250 FTH_0110 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762789.1 111845 R 393011 CDS YP_762790.1 115314067 4307251 complement(113018..113641) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 113641 4307251 FTH_0111 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762790.1 113018 R 393011 CDS YP_762791.1 115314068 4307252 complement(113654..115084) 1 NC_008369.1 hypothetical protein 115084 4307252 FTH_0112 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762791.1 113654 R 393011 CDS YP_762792.1 115314069 4307253 complement(115097..115618) 1 NC_008369.1 hypothetical protein 115618 4307253 FTH_0113 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762792.1 115097 R 393011 CDS YP_762793.1 115314070 4307255 complement(117355..117849) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 117849 4307255 FTH_0115 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762793.1 117355 R 393011 CDS YP_762794.1 115314071 4307256 complement(117862..118239) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 118239 4307256 FTH_0116 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762794.1 117862 R 393011 CDS YP_762795.1 115314072 4307257 complement(118229..121510) 1 NC_008369.1 PdpB2; conserved in Francisella genomes; protein PdpB 121510 pdpB2 4307257 pdpB2 Francisella tularensis subsp. holarctica OSU18 protein PdpB YP_762795.1 118229 R 393011 CDS YP_762796.1 115314073 4307258 complement(121515..123977) 1 NC_008369.1 PdpA2; conserved in Francisella genomes; protein PdpA 123977 pdpA2 4307258 pdpA2 Francisella tularensis subsp. holarctica OSU18 protein PdpA YP_762796.1 121515 R 393011 CDS YP_762797.1 115314074 4307264 129549..130265 1 NC_008369.1 formate dehydrogenase 130265 4307264 FTH_0119 Francisella tularensis subsp. holarctica OSU18 formate dehydrogenase YP_762797.1 129549 D 393011 CDS YP_762798.1 115314075 4307267 complement(132582..133469) 1 NC_008369.1 branched-chain amino acid aminotransferase; branched-chain-amino-acid transaminase 133469 ilvE 4307267 ilvE Francisella tularensis subsp. holarctica OSU18 branched-chain-amino-acid transaminase YP_762798.1 132582 R 393011 CDS YP_762799.1 115314076 4307268 complement(133870..136503) 1 NC_008369.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 136503 ppdK 4307268 ppdK Francisella tularensis subsp. holarctica OSU18 pyruvate phosphate dikinase YP_762799.1 133870 R 393011 CDS YP_762800.1 115314077 4307269 complement(137330..139573) 1 NC_008369.1 FeoB family ferrous iron (Fe2+) uptake protein 139573 4307269 FTH_0124 Francisella tularensis subsp. holarctica OSU18 FeoB family ferrous iron (Fe2+) uptake protein YP_762800.1 137330 R 393011 CDS YP_762801.1 115314078 4307270 complement(139674..140162) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 140162 4307270 FTH_0125 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762801.1 139674 R 393011 CDS YP_762802.1 115314079 4307271 complement(join(140119..140670,140670..140999)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 140999 isftu1 4307271 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_762802.1 140119 R 393011 CDS YP_762803.1 115314080 4307274 complement(142771..143739) 1 NC_008369.1 LpsA; lipopolysaccharide biosynthesis protein 143739 4307274 FTH_0129 Francisella tularensis subsp. holarctica OSU18 lipopolysaccharide biosynthesis protein YP_762803.1 142771 R 393011 CDS YP_762804.1 115314081 4307275 143928..145778 1 NC_008369.1 ribonuclease II 145778 4307275 FTH_0130 Francisella tularensis subsp. holarctica OSU18 ribonuclease II YP_762804.1 143928 D 393011 CDS YP_762805.1 115314082 4307276 146115..146783 1 NC_008369.1 carboxylesterase/phospholipase family protein 146783 4307276 FTH_0131 Francisella tularensis subsp. holarctica OSU18 carboxylesterase/phospholipase family protein YP_762805.1 146115 D 393011 CDS YP_762806.1 115314083 4307277 146780..147682 1 NC_008369.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 147682 hemC 4307277 hemC Francisella tularensis subsp. holarctica OSU18 porphobilinogen deaminase YP_762806.1 146780 D 393011 CDS YP_762807.1 115314084 4307278 147683..148018 1 NC_008369.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 148018 4307278 FTH_0133 Francisella tularensis subsp. holarctica OSU18 camphor resistance protein CrcB YP_762807.1 147683 D 393011 CDS YP_762808.1 115314085 4307279 148071..148478 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 148478 4307279 FTH_0134 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762808.1 148071 D 393011 CDS YP_762809.1 115314086 4307280 148618..148779 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 148779 4307280 FTH_0135 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762809.1 148618 D 393011 CDS YP_762810.1 115314087 4307281 148856..149209 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 149209 4307281 FTH_0136 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762810.1 148856 D 393011 CDS YP_762811.1 115314088 4307282 complement(149206..149379) 1 NC_008369.1 hypothetical protein 149379 4307282 FTH_0137 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762811.1 149206 R 393011 CDS YP_762812.1 115314089 4307283 149508..151307 1 NC_008369.1 ABC transporter ATP-binding protein 151307 4307283 FTH_0138 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_762812.1 149508 D 393011 CDS YP_762813.1 115314090 4307284 151326..152642 1 NC_008369.1 ABC transporter ATP-binding protein 152642 4307284 FTH_0139 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_762813.1 151326 D 393011 CDS YP_762814.1 115314091 4307286 154351..156237 1 NC_008369.1 CPA1 family sodium:proton (Na+:H+) antiporter-1 156237 4307286 FTH_0141 Francisella tularensis subsp. holarctica OSU18 CPA1 family sodium:proton (Na+:H+) antiporter-1 YP_762814.1 154351 D 393011 CDS YP_762815.1 115314092 4307287 156222..156761 1 NC_008369.1 carbonic anhydrase; carbonate dehydratase 156761 4307287 FTH_0142 Francisella tularensis subsp. holarctica OSU18 carbonate dehydratase YP_762815.1 156222 D 393011 CDS YP_762816.1 115314093 4307288 156712..157356 1 NC_008369.1 outer membrane lipoprotein 157356 lolB 4307288 lolB Francisella tularensis subsp. holarctica OSU18 outer membrane lipoprotein YP_762816.1 156712 D 393011 CDS YP_762817.1 115314094 4307289 157344..158171 1 NC_008369.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 158171 ipk 4307289 ipk Francisella tularensis subsp. holarctica OSU18 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_762817.1 157344 D 393011 CDS YP_762818.1 115314095 4307291 158360..158680 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 158680 4307291 FTH_0145 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762818.1 158360 D 393011 CDS YP_762819.1 115314096 4307292 join(158704..159033,159033..159584) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 159584 isftu1 4307292 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_762819.1 158704 D 393011 CDS YP_762820.1 115314097 4307293 159556..159825 1 NC_008369.1 hypothetical protein 159825 4307293 FTH_0147 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762820.1 159556 D 393011 CDS YP_762821.1 115314098 4307295 complement(160142..160345) 1 NC_008369.1 hypothetical protein 160345 4307295 FTH_0149 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762821.1 160142 R 393011 CDS YP_762822.1 115314099 4307296 complement(160426..161421) 1 NC_008369.1 PiT family inorganic phosphate transporter 161421 4307296 FTH_0150 Francisella tularensis subsp. holarctica OSU18 PiT family inorganic phosphate transporter YP_762822.1 160426 R 393011 CDS YP_762823.1 115314100 4307297 complement(161439..162095) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 162095 4307297 FTH_0151 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762823.1 161439 R 393011 CDS YP_762824.1 115314101 4307299 complement(163884..164660) 1 NC_008369.1 hydrolase subunit 164660 ybgK 4307299 ybgK Francisella tularensis subsp. holarctica OSU18 hydrolase subunit YP_762824.1 163884 R 393011 CDS YP_762825.1 115314102 4307300 complement(164781..165398) 1 NC_008369.1 LamB/YcsF family protein 165398 4307300 FTH_0154 Francisella tularensis subsp. holarctica OSU18 LamB/YcsF family protein YP_762825.1 164781 R 393011 CDS YP_762826.1 115314103 4307978 complement(165398..166015) 1 NC_008369.1 hypothetical protein 166015 4307978 FTH_0155 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762826.1 165398 R 393011 CDS YP_762827.1 115314104 4307980 complement(join(167091..167642,167642..167971)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 167971 isftu1 4307980 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_762827.1 167091 R 393011 CDS YP_762828.1 115314105 4307982 complement(168331..169167) 1 NC_008369.1 universal stress protein 169167 usp 4307982 usp Francisella tularensis subsp. holarctica OSU18 universal stress protein YP_762828.1 168331 R 393011 CDS YP_762829.1 115314106 4307983 complement(169243..171984) 1 NC_008369.1 DNA/RNA helicase 171984 4307983 FTH_0160 Francisella tularensis subsp. holarctica OSU18 DNA/RNA helicase YP_762829.1 169243 R 393011 CDS YP_762830.1 115314107 4307984 complement(171968..172747) 1 NC_008369.1 hypothetical protein 172747 4307984 FTH_0161 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762830.1 171968 R 393011 CDS YP_762831.1 115314108 4307985 complement(172819..173382) 1 NC_008369.1 hypothetical protein 173382 4307985 FTH_0162 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762831.1 172819 R 393011 CDS YP_762832.1 115314109 4307986 173459..173635 1 NC_008369.1 hypothetical protein 173635 4307986 FTH_0163 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762832.1 173459 D 393011 CDS YP_762833.1 115314110 4307987 173724..174194 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 174194 4307987 FTH_0164 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762833.1 173724 D 393011 CDS YP_762834.1 115314111 4307988 complement(174205..175077) 1 NC_008369.1 tetrapyrrole methyltransferase 175077 4307988 FTH_0165 Francisella tularensis subsp. holarctica OSU18 tetrapyrrole methyltransferase YP_762834.1 174205 R 393011 CDS YP_762835.1 115314112 4307990 complement(176517..177290) 1 NC_008369.1 5-dehydroshikimate reductase; shikimate dehydrogenase 177290 aroE1 4307990 aroE1 Francisella tularensis subsp. holarctica OSU18 shikimate dehydrogenase YP_762835.1 176517 R 393011 CDS YP_762836.1 115314113 4307991 177417..177875 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 177875 4307991 FTH_0168 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762836.1 177417 D 393011 CDS YP_762837.1 115314114 4307992 177972..178106 1 NC_008369.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 178106 rpmH 4307992 rpmH Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L34 YP_762837.1 177972 D 393011 CDS YP_762838.1 115314115 4307993 178096..178449 1 NC_008369.1 ribonuclease P 178449 rnpA 4307993 rnpA Francisella tularensis subsp. holarctica OSU18 ribonuclease P YP_762838.1 178096 D 393011 CDS YP_762839.1 115314116 4307994 178461..178673 1 NC_008369.1 hypothetical protein 178673 4307994 FTH_0171 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762839.1 178461 D 393011 CDS YP_762840.1 115314117 4307995 178682..180337 1 NC_008369.1 inner membrane protein 180337 4307995 FTH_0172 Francisella tularensis subsp. holarctica OSU18 inner membrane protein YP_762840.1 178682 D 393011 CDS YP_762841.1 115314118 4307996 180344..181243 1 NC_008369.1 acyltransferase 181243 4307996 FTH_0173 Francisella tularensis subsp. holarctica OSU18 acyltransferase YP_762841.1 180344 D 393011 CDS YP_762842.1 115314119 4307997 181304..182227 1 NC_008369.1 acyltransferase 182227 4307997 FTH_0174 Francisella tularensis subsp. holarctica OSU18 acyltransferase YP_762842.1 181304 D 393011 CDS YP_762843.1 115314120 4307998 182240..182647 1 NC_008369.1 type IV pilus assembly protein 182647 4307998 FTH_0175 Francisella tularensis subsp. holarctica OSU18 type IV pilus assembly protein YP_762843.1 182240 D 393011 CDS YP_762844.1 115314121 4307999 182687..183256 1 NC_008369.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 183256 efp 4307999 efp Francisella tularensis subsp. holarctica OSU18 elongation factor P YP_762844.1 182687 D 393011 CDS YP_762845.1 115314122 4308000 183259..183795 1 NC_008369.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 183795 4308000 FTH_0177 Francisella tularensis subsp. holarctica OSU18 oligoribonuclease YP_762845.1 183259 D 393011 CDS YP_762846.1 115314123 4308003 complement(184909..186027) 1 NC_008369.1 ABC transporter ATP-binding protein 186027 4308003 FTH_0180 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_762846.1 184909 R 393011 CDS YP_762847.1 115314124 4308004 complement(186095..186835) 1 NC_008369.1 hypothetical protein 186835 4308004 FTH_0181 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762847.1 186095 R 393011 CDS YP_762848.1 115314125 4308005 complement(186914..187012) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 187012 4308005 FTH_0182 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762848.1 186914 R 393011 CDS YP_762849.1 115314126 4308006 complement(187028..188221) 1 NC_008369.1 cytochrome d ubiquinol oxidase subunit II 188221 cydB 4308006 cydB Francisella tularensis subsp. holarctica OSU18 cytochrome d ubiquinol oxidase subunit II YP_762849.1 187028 R 393011 CDS YP_762850.1 115314127 4308007 complement(188232..189986) 1 NC_008369.1 cytochrome d ubiquinol oxidase subunit I 189986 cydA 4308007 cydA Francisella tularensis subsp. holarctica OSU18 cytochrome d ubiquinol oxidase subunit I YP_762850.1 188232 R 393011 CDS YP_762851.1 115314128 4308008 complement(190439..191806) 1 NC_008369.1 major facilitator transporter 191806 4308008 FTH_0185 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_762851.1 190439 R 393011 CDS YP_762852.1 115314129 4308009 192166..193068 1 NC_008369.1 cytochrome o ubiquinol oxidase subunit II 193068 cyoA 4308009 cyoA Francisella tularensis subsp. holarctica OSU18 cytochrome o ubiquinol oxidase subunit II YP_762852.1 192166 D 393011 CDS YP_762853.1 115314130 4308010 193107..195137 1 NC_008369.1 cytochrome o ubiquinol oxidase subunit I 195137 cyoB 4308010 cyoB Francisella tularensis subsp. holarctica OSU18 cytochrome o ubiquinol oxidase subunit I YP_762853.1 193107 D 393011 CDS YP_762854.1 115314131 4308011 195134..195736 1 NC_008369.1 cytochrome o ubiquinol oxidase subunit III 195736 cyoC 4308011 cyoC Francisella tularensis subsp. holarctica OSU18 cytochrome o ubiquinol oxidase subunit III YP_762854.1 195134 D 393011 CDS YP_762855.1 115314132 4308012 195738..196070 1 NC_008369.1 cytochrome o ubiquinol oxidase subunit IV 196070 cyoD 4308012 cyoD Francisella tularensis subsp. holarctica OSU18 cytochrome o ubiquinol oxidase subunit IV YP_762855.1 195738 D 393011 CDS YP_762856.1 115314133 4308013 196101..196949 1 NC_008369.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 196949 cyoE 4308013 cyoE Francisella tularensis subsp. holarctica OSU18 protoheme IX farnesyltransferase YP_762856.1 196101 D 393011 CDS YP_762857.1 115314134 4308014 complement(197094..198137) 1 NC_008369.1 UDP-3-[O-3-hydroxymyristoyl] glucosamine N-acyltransferase 198137 lpxD 4308014 lpxD Francisella tularensis subsp. holarctica OSU18 UDP-3-[O-3-hydroxymyristoyl] glucosamine N-acyltransferase YP_762857.1 197094 R 393011 CDS YP_762858.1 115314135 4308015 complement(198212..198907) 1 NC_008369.1 hypothetical protein 198907 4308015 FTH_0192 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762858.1 198212 R 393011 CDS YP_762859.1 115314136 4308016 complement(198907..199758) 1 NC_008369.1 pyridoxamine kinase; pyridoxal kinase 199758 pdxY 4308016 pdxY Francisella tularensis subsp. holarctica OSU18 pyridoxal kinase YP_762859.1 198907 R 393011 CDS YP_762860.1 115314137 4308017 complement(199765..200199) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 200199 4308017 FTH_0194 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762860.1 199765 R 393011 CDS YP_762861.1 115314138 4308018 200345..201301 1 NC_008369.1 MoxR family ATPase 201301 moxR 4308018 moxR Francisella tularensis subsp. holarctica OSU18 MoxR family ATPase YP_762861.1 200345 D 393011 CDS YP_762862.1 115314139 4308019 201314..202225 1 NC_008369.1 hypothetical protein 202225 4308019 FTH_0196 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762862.1 201314 D 393011 CDS YP_762863.1 115314140 4308020 202215..202691 1 NC_008369.1 hypothetical protein 202691 4308020 FTH_0197 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762863.1 202215 D 393011 CDS YP_762864.1 115314141 4308021 202670..203689 1 NC_008369.1 hypothetical protein 203689 4308021 FTH_0198 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762864.1 202670 D 393011 CDS YP_762865.1 115314142 4308022 203691..204689 1 NC_008369.1 hypothetical protein 204689 4308022 FTH_0199 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762865.1 203691 D 393011 CDS YP_762866.1 115314143 4308023 204698..205414 1 NC_008369.1 hypothetical protein 205414 4308023 FTH_0200 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762866.1 204698 D 393011 CDS YP_762867.1 115314144 4308024 205404..207029 1 NC_008369.1 hypothetical protein 207029 4308024 FTH_0201 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762867.1 205404 D 393011 CDS YP_762868.1 115314145 4308025 207030..207704 1 NC_008369.1 5-oxoprolyl-peptidase; pyroglutamyl-peptidase I 207704 pcp 4308025 pcp Francisella tularensis subsp. holarctica OSU18 pyroglutamyl-peptidase I YP_762868.1 207030 D 393011 CDS YP_762869.1 115314146 4308026 207712..208194 1 NC_008369.1 putative cytochrome c-type biogenesis protein 208194 4308026 FTH_0203 Francisella tularensis subsp. holarctica OSU18 putative cytochrome c-type biogenesis protein YP_762869.1 207712 D 393011 CDS YP_762870.1 115314147 4308027 208225..208665 1 NC_008369.1 DNA nucleotidyltransferase (DNA-directed); DNA polymerase III subunit chi 208665 holC 4308027 holC Francisella tularensis subsp. holarctica OSU18 DNA polymerase III subunit chi YP_762870.1 208225 D 393011 CDS YP_762871.1 115314148 4308028 208797..211556 1 NC_008369.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 211556 valS 4308028 valS Francisella tularensis subsp. holarctica OSU18 valyl-tRNA synthetase YP_762871.1 208797 D 393011 CDS YP_762872.1 115314149 4308029 211585..212472 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 212472 4308029 FTH_0206 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762872.1 211585 D 393011 CDS YP_762873.1 115314150 4308030 212427..213413 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 213413 4308030 FTH_0207 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762873.1 212427 D 393011 CDS YP_762874.1 115314151 4308032 complement(213910..215067) 1 NC_008369.1 cytochrome b2; L-lactate dehydrogenase 215067 lldD 4308032 lldD Francisella tularensis subsp. holarctica OSU18 L-lactate dehydrogenase YP_762874.1 213910 R 393011 CDS YP_762875.1 115314152 4308033 complement(215057..215740) 1 NC_008369.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 215740 nfnB 4308033 nfnB Francisella tularensis subsp. holarctica OSU18 dihydropteridine reductase YP_762875.1 215057 R 393011 CDS YP_762876.1 115314153 4308034 215880..216257 1 NC_008369.1 MutT/nudix hydrolase 216257 4308034 FTH_0211 Francisella tularensis subsp. holarctica OSU18 MutT/nudix hydrolase YP_762876.1 215880 D 393011 CDS YP_762877.1 115314154 4308035 216430..217821 1 NC_008369.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 217821 fumC 4308035 fumC Francisella tularensis subsp. holarctica OSU18 fumarate hydratase YP_762877.1 216430 D 393011 CDS YP_762878.1 115314155 4308036 217951..219357 1 NC_008369.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 219357 gltX 4308036 gltX Francisella tularensis subsp. holarctica OSU18 glutamyl-tRNA synthetase YP_762878.1 217951 D 393011 CDS YP_762879.1 115314156 4308039 221382..222674 1 NC_008369.1 APC family amino acid-polyamine-organocation transporter 222674 4308039 FTH_0216 Francisella tularensis subsp. holarctica OSU18 APC family amino acid-polyamine-organocation transporter YP_762879.1 221382 D 393011 CDS YP_762880.1 115314157 4308041 complement(223168..224091) 1 NC_008369.1 hypothetical protein 224091 4308041 FTH_0217 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762880.1 223168 R 393011 CDS YP_762881.1 115314158 4308042 complement(224173..224715) 1 NC_008369.1 tetrahydrofolate dehydrogenase; dihydrofolate reductase type I 224715 folA 4308042 folA Francisella tularensis subsp. holarctica OSU18 dihydrofolate reductase type I YP_762881.1 224173 R 393011 CDS YP_762882.1 115314159 4308043 224908..225627 1 NC_008369.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 225627 rpsB 4308043 rpsB Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S2 YP_762882.1 224908 D 393011 CDS YP_762883.1 115314160 4308044 225649..226518 1 NC_008369.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 226518 tsf 4308044 tsf Francisella tularensis subsp. holarctica OSU18 elongation factor Ts YP_762883.1 225649 D 393011 CDS YP_762884.1 115314161 4308045 226522..227271 1 NC_008369.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 227271 pyrH 4308045 pyrH Francisella tularensis subsp. holarctica OSU18 uridylate kinase YP_762884.1 226522 D 393011 CDS YP_762885.1 115314162 4308046 227301..227858 1 NC_008369.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 227858 frr 4308046 frr Francisella tularensis subsp. holarctica OSU18 ribosome recycling factor YP_762885.1 227301 D 393011 CDS YP_762886.1 115314163 4308047 227891..228664 1 NC_008369.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 228664 uppS 4308047 uppS Francisella tularensis subsp. holarctica OSU18 undecaprenyl pyrophosphate synthase YP_762886.1 227891 D 393011 CDS YP_762887.1 115314164 4308048 228678..229472 1 NC_008369.1 CDP-diacylglycerol synthase; phosphatidate cytidylyltransferase 229472 4308048 FTH_0224 Francisella tularensis subsp. holarctica OSU18 phosphatidate cytidylyltransferase YP_762887.1 228678 D 393011 CDS YP_762888.1 115314165 4308049 229482..229928 1 NC_008369.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 229928 dut 4308049 dut Francisella tularensis subsp. holarctica OSU18 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_762888.1 229482 D 393011 CDS YP_762889.1 115314166 4308050 229932..230528 1 NC_008369.1 3-phosphatidyl-1'-glycerol-3??-phosphate synthase; phosphatidylglycerophosphate synthetase 230528 pgsA 4308050 pgsA Francisella tularensis subsp. holarctica OSU18 phosphatidylglycerophosphate synthetase YP_762889.1 229932 D 393011 CDS YP_762890.1 115314167 4308051 230663..231037 1 NC_008369.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 231037 rpsL 4308051 rpsL Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S12 YP_762890.1 230663 D 393011 CDS YP_762891.1 115314168 4308052 231076..231549 1 NC_008369.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 231549 rpsG 4308052 rpsG Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S7 YP_762891.1 231076 D 393011 CDS YP_762892.1 115314169 4308053 231564..233678 1 NC_008369.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 233678 fusA 4308053 fusA Francisella tularensis subsp. holarctica OSU18 elongation factor G YP_762892.1 231564 D 393011 CDS YP_762893.1 115314170 4308054 233699..234016 1 NC_008369.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 234016 rpsJ 4308054 rpsJ Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S10 YP_762893.1 233699 D 393011 CDS YP_762894.1 115314171 4308055 234120..234752 1 NC_008369.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 234752 rplC 4308055 rplC Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L3 YP_762894.1 234120 D 393011 CDS YP_762895.1 115314172 4308056 234785..235408 1 NC_008369.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 235408 rplD 4308056 rplD Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L4 YP_762895.1 234785 D 393011 CDS YP_762896.1 115314173 4308057 235405..235704 1 NC_008369.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 235704 rplW 4308057 rplW Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L23 YP_762896.1 235405 D 393011 CDS YP_762897.1 115314174 4308058 235726..236550 1 NC_008369.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 236550 rplB 4308058 rplB Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L2 YP_762897.1 235726 D 393011 CDS YP_762898.1 115314175 4308059 236565..236843 1 NC_008369.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 236843 rpsS 4308059 rpsS Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S19 YP_762898.1 236565 D 393011 CDS YP_762899.2 394894298 4308060 236859..237194 1 NC_008369.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 237194 rplV 4308060 rplV Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L22 YP_762899.2 236859 D 393011 CDS YP_762900.1 115314177 4308061 237209..237880 1 NC_008369.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 237880 rpsC 4308061 rpsC Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S3 YP_762900.1 237209 D 393011 CDS YP_762901.1 115314178 4308062 237880..238293 1 NC_008369.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 238293 rplP 4308062 rplP Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L16 YP_762901.1 237880 D 393011 CDS YP_762902.1 115314179 4308063 238293..238493 1 NC_008369.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 238493 rpmC 4308063 rpmC Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L29 YP_762902.1 238293 D 393011 CDS YP_762903.1 115314180 4308064 238506..238757 1 NC_008369.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 238757 rpsQ 4308064 rpsQ Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S17 YP_762903.1 238506 D 393011 CDS YP_762904.1 115314181 4308065 238849..239217 1 NC_008369.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 239217 rplN 4308065 rplN Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L14 YP_762904.1 238849 D 393011 CDS YP_762905.1 115314182 4308066 239239..239556 1 NC_008369.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 239556 rplX 4308066 rplX Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L24 YP_762905.1 239239 D 393011 CDS YP_762906.1 115314183 4308067 239568..240107 1 NC_008369.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 240107 rplE 4308067 rplE Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L5 YP_762906.1 239568 D 393011 CDS YP_762907.1 115314184 4308068 240126..240431 1 NC_008369.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 240431 rpsN 4308068 rpsN Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S14 YP_762907.1 240126 D 393011 CDS YP_762908.1 115314185 4308069 240448..240846 1 NC_008369.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 240846 rpsH 4308069 rpsH Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S8 YP_762908.1 240448 D 393011 CDS YP_762909.1 115314186 4308070 240865..241401 1 NC_008369.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 241401 rplF 4308070 rplF Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L6 YP_762909.1 240865 D 393011 CDS YP_762910.1 115314187 4307140 241424..241777 1 NC_008369.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 241777 rplR 4307140 rplR Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L18 YP_762910.1 241424 D 393011 CDS YP_762911.1 115314188 4307141 241805..242305 1 NC_008369.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 242305 rpsE 4307141 rpsE Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S5 YP_762911.1 241805 D 393011 CDS YP_762912.1 115314189 4307142 242312..242497 1 NC_008369.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 242497 rpmD 4307142 rpmD Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L30 YP_762912.1 242312 D 393011 CDS YP_762913.1 115314190 4307143 242504..242935 1 NC_008369.1 late assembly protein; 50S ribosomal protein L15 242935 rplO 4307143 rplO Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L15 YP_762913.1 242504 D 393011 CDS YP_762914.1 115314191 4307144 242946..244271 1 NC_008369.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 244271 secY 4307144 secY Francisella tularensis subsp. holarctica OSU18 preprotein translocase subunit SecY YP_762914.1 242946 D 393011 CDS YP_762915.1 115314192 4307146 244525..244881 1 NC_008369.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 244881 rpsM 4307146 rpsM Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S13 YP_762915.1 244525 D 393011 CDS YP_762916.1 115314193 4307147 244920..245309 1 NC_008369.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 245309 rpsK 4307147 rpsK Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S11 YP_762916.1 244920 D 393011 CDS YP_762917.1 115314194 4307148 245331..245951 1 NC_008369.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 245951 rpsD 4307148 rpsD Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S4 YP_762917.1 245331 D 393011 CDS YP_762918.1 115314195 4307149 246009..246980 1 NC_008369.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 246980 rpoA1 4307149 rpoA1 Francisella tularensis subsp. holarctica OSU18 DNA-directed RNA polymerase subunit alpha YP_762918.1 246009 D 393011 CDS YP_762919.1 115314196 4307150 247025..247462 1 NC_008369.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 247462 rplQ 4307150 rplQ Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L17 YP_762919.1 247025 D 393011 CDS YP_762920.1 115314197 4307154 249278..250273 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 250273 4307154 FTH_0261 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762920.1 249278 D 393011 CDS YP_762921.1 115314198 4307155 complement(join(250469..251020,251020..251349)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 251349 isftu1 4307155 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_762921.1 250469 R 393011 CDS YP_762922.1 115314199 4307161 complement(256600..257949) 1 NC_008369.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 257949 4307161 FTH_0268 Francisella tularensis subsp. holarctica OSU18 glutamate dehydrogenase YP_762922.1 256600 R 393011 CDS YP_762923.1 115314200 4307164 260000..261169 1 NC_008369.1 DAP decarboxylase; diaminopimelate decarboxylase 261169 lysA1 4307164 lysA1 Francisella tularensis subsp. holarctica OSU18 diaminopimelate decarboxylase YP_762923.1 260000 D 393011 CDS YP_762924.1 115314201 4307165 261181..262560 1 NC_008369.1 APC family amino acid-polyamine-organocation transporter 262560 gabP 4307165 gabP Francisella tularensis subsp. holarctica OSU18 APC family amino acid-polyamine-organocation transporter YP_762924.1 261181 D 393011 CDS YP_762925.1 115314202 4307167 complement(263037..263609) 1 NC_008369.1 6-O-methylguanine-DNA methyltransferase; methylated-DNA--[protein]-cysteine S-methyltransferase 263609 4307167 FTH_0274 Francisella tularensis subsp. holarctica OSU18 methylated-DNA--[protein]-cysteine S-methyltransferase YP_762925.1 263037 R 393011 CDS YP_762926.1 115314203 4307168 263639..264358 1 NC_008369.1 hypothetical protein 264358 4307168 FTH_0275 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762926.1 263639 D 393011 CDS YP_762927.1 115314204 4307169 264361..265779 1 NC_008369.1 pyruvate/2-oxoglutarate dehydrogenase 265779 4307169 FTH_0276 Francisella tularensis subsp. holarctica OSU18 pyruvate/2-oxoglutarate dehydrogenase YP_762927.1 264361 D 393011 CDS YP_762928.1 115314205 4307170 265776..266345 1 NC_008369.1 phosphatidylglycerophosphate synthase 266345 4307170 FTH_0277 Francisella tularensis subsp. holarctica OSU18 phosphatidylglycerophosphate synthase YP_762928.1 265776 D 393011 CDS YP_762929.1 115314206 4307171 266342..266671 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 266671 4307171 FTH_0278 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762929.1 266342 D 393011 CDS YP_762930.1 115314207 4307173 267656..268582 1 NC_008369.1 chaperone DnaJ 268582 dnaJ1 4307173 dnaJ1 Francisella tularensis subsp. holarctica OSU18 chaperone DnaJ YP_762930.1 267656 D 393011 CDS YP_762931.1 115314208 4307174 complement(268572..269456) 1 NC_008369.1 DMT superfamily drug/metabolite transporter 269456 4307174 FTH_0281 Francisella tularensis subsp. holarctica OSU18 DMT superfamily drug/metabolite transporter YP_762931.1 268572 R 393011 CDS YP_762932.1 115314209 4307175 269647..270843 1 NC_008369.1 HAAAP family hydroxy/aromatic amino acid permease 270843 4307175 FTH_0282 Francisella tularensis subsp. holarctica OSU18 HAAAP family hydroxy/aromatic amino acid permease YP_762932.1 269647 D 393011 CDS YP_762933.1 115314210 4307176 270877..271233 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 271233 4307176 FTH_0283 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762933.1 270877 D 393011 CDS YP_762934.1 115314211 4307177 271536..273545 1 NC_008369.1 GTP pyrophosphokinase; GTP diphosphokinase 273545 spoT1 4307177 spoT1 Francisella tularensis subsp. holarctica OSU18 GTP diphosphokinase YP_762934.1 271536 D 393011 CDS YP_762935.1 115314212 4307178 complement(273661..274293) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 274293 4307178 FTH_0285 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762935.1 273661 R 393011 CDS YP_762936.1 115314213 4307179 complement(274370..274948) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 274948 4307179 FTH_0286 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762936.1 274370 R 393011 CDS YP_762937.1 115314214 4307180 275036..275650 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 275650 4307180 FTH_0287 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762937.1 275036 D 393011 CDS YP_762938.1 115314215 4307181 complement(275657..276382) 1 NC_008369.1 hypothetical protein 276382 4307181 FTH_0288 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762938.1 275657 R 393011 CDS YP_762939.1 115314216 4307182 complement(276382..277260) 1 NC_008369.1 integrase/recombinase XerC 277260 xerC 4307182 xerC Francisella tularensis subsp. holarctica OSU18 integrase/recombinase XerC YP_762939.1 276382 R 393011 CDS YP_762940.1 115314217 4307183 complement(277270..278481) 1 NC_008369.1 HAAAP family hydroxy/aromatic amino acid permease 278481 4307183 FTH_0290 Francisella tularensis subsp. holarctica OSU18 HAAAP family hydroxy/aromatic amino acid permease YP_762940.1 277270 R 393011 CDS YP_762941.1 115314218 4307184 complement(278505..279509) 1 NC_008369.1 hypothetical protein 279509 4307184 FTH_0291 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762941.1 278505 R 393011 CDS YP_762942.1 115314219 4307185 complement(279515..279727) 1 NC_008369.1 hypothetical protein 279727 4307185 FTH_0292 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762942.1 279515 R 393011 CDS YP_762943.1 115314220 4307602 complement(279921..280364) 1 NC_008369.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 280364 secB2 4307602 secB2 Francisella tularensis subsp. holarctica OSU18 preprotein translocase subunit SecB YP_762943.1 279921 R 393011 CDS YP_762944.1 115314221 4307603 complement(280441..283008) 1 NC_008369.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 283008 mutS 4307603 mutS Francisella tularensis subsp. holarctica OSU18 DNA mismatch repair protein MutS YP_762944.1 280441 R 393011 CDS YP_762945.1 115314222 4307604 283142..284089 1 NC_008369.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 284089 accA 4307604 accA Francisella tularensis subsp. holarctica OSU18 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_762945.1 283142 D 393011 CDS YP_762946.1 115314223 4307605 284109..284612 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 284612 4307605 FTH_0296 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762946.1 284109 D 393011 CDS YP_762947.1 115314224 4307606 284593..285606 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 285606 4307606 FTH_0297 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762947.1 284593 D 393011 CDS YP_762948.1 115314225 4307607 285615..287576 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 287576 4307607 FTH_0298 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762948.1 285615 D 393011 CDS YP_762949.1 115314226 4307608 287573..288457 1 NC_008369.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 288457 murQ 4307608 murQ Francisella tularensis subsp. holarctica OSU18 N-acetylmuramic acid 6-phosphate etherase YP_762949.1 287573 D 393011 CDS YP_762950.1 115314227 4307609 288459..288854 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 288854 4307609 FTH_0300 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762950.1 288459 D 393011 CDS YP_762951.1 115314228 4307612 290668..291243 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 291243 4307612 FTH_0303 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762951.1 290668 D 393011 CDS YP_762952.1 115314229 4307613 291462..291635 1 NC_008369.1 hypothetical protein 291635 4307613 FTH_0304 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762952.1 291462 D 393011 CDS YP_762953.1 115314230 4307614 complement(291640..292938) 1 NC_008369.1 CPA1 family monovalent cation:proton (H+) antiporter-1 292938 nhaP 4307614 nhaP Francisella tularensis subsp. holarctica OSU18 CPA1 family monovalent cation:proton (H+) antiporter-1 YP_762953.1 291640 R 393011 CDS YP_762954.1 115314231 4307615 complement(292948..293673) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 293673 4307615 FTH_0306 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762954.1 292948 R 393011 CDS YP_762955.1 115314232 4307616 complement(293675..294679) 1 NC_008369.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 294679 trpS 4307616 trpS Francisella tularensis subsp. holarctica OSU18 tryptophanyl-tRNA synthetase YP_762955.1 293675 R 393011 CDS YP_762956.1 115314233 4307619 complement(294976..295590) 1 NC_008369.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 295590 coaE 4307619 coaE Francisella tularensis subsp. holarctica OSU18 dephospho-CoA kinase YP_762956.1 294976 R 393011 CDS YP_762957.1 115314234 4307620 295719..296855 1 NC_008369.1 hypothetical protein 296855 4307620 FTH_0309 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762957.1 295719 D 393011 CDS YP_762958.1 115314235 4307621 297139..299820 1 NC_008369.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 299820 aceE 4307621 aceE Francisella tularensis subsp. holarctica OSU18 pyruvate dehydrogenase subunit E1 YP_762958.1 297139 D 393011 CDS YP_762959.1 115314236 4307622 299838..301433 1 NC_008369.1 acetyl-CoA:dihydrolipoamide S-acetyltransferase; dihydrolipoamide acetyltransferase 301433 aceF 4307622 aceF Francisella tularensis subsp. holarctica OSU18 dihydrolipoamide acetyltransferase YP_762959.1 299838 D 393011 CDS YP_762960.1 115314237 4307623 301447..302859 1 NC_008369.1 dehydrolipoate dehydrogenase; dihydrolipoamide dehydrogenase 302859 lpd 4307623 lpd Francisella tularensis subsp. holarctica OSU18 dihydrolipoamide dehydrogenase YP_762960.1 301447 D 393011 CDS YP_762961.1 115314238 4307625 join(303229..303558,303558..304109) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 304109 isftu1 4307625 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_762961.1 303229 D 393011 CDS YP_762962.1 115314239 4307626 304237..304884 1 NC_008369.1 MutT/nudix family protein 304884 mutT 4307626 mutT Francisella tularensis subsp. holarctica OSU18 MutT/nudix family protein YP_762962.1 304237 D 393011 CDS YP_762963.1 115314240 4307627 304902..305255 1 NC_008369.1 arsenate reductase 305255 arsC1 4307627 arsC1 Francisella tularensis subsp. holarctica OSU18 arsenate reductase YP_762963.1 304902 D 393011 CDS YP_762964.1 115314241 4307628 complement(305279..305614) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 305614 4307628 FTH_0317 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762964.1 305279 R 393011 CDS YP_762965.1 115314242 4307629 complement(305791..306036) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 306036 4307629 FTH_0318 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762965.1 305791 R 393011 CDS YP_762966.1 115314243 4307630 complement(306114..307427) 1 NC_008369.1 NCS2 family xanthine:uracil symporter-2 307427 4307630 FTH_0319 Francisella tularensis subsp. holarctica OSU18 NCS2 family xanthine:uracil symporter-2 YP_762966.1 306114 R 393011 CDS YP_762967.1 115314244 4307631 complement(307494..309080) 1 NC_008369.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 309080 aspD 4307631 aspD Francisella tularensis subsp. holarctica OSU18 aspartate aminotransferase YP_762967.1 307494 R 393011 CDS YP_762968.1 115314245 4307634 complement(311989..313242) 1 NC_008369.1 OmpA family protein 313242 4307634 FTH_0323 Francisella tularensis subsp. holarctica OSU18 OmpA family protein YP_762968.1 311989 R 393011 CDS YP_762969.1 115314246 4307635 313434..313898 1 NC_008369.1 cyclophilin; peptidyl-prolyl isomerase 313898 4307635 FTH_0324 Francisella tularensis subsp. holarctica OSU18 peptidyl-prolyl isomerase YP_762969.1 313434 D 393011 CDS YP_762970.1 115314247 4307636 313879..314835 1 NC_008369.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 314835 ispH 4307636 ispH Francisella tularensis subsp. holarctica OSU18 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_762970.1 313879 D 393011 CDS YP_762971.1 115314248 4307637 314837..315199 1 NC_008369.1 chorismate mutase 315199 4307637 FTH_0326 Francisella tularensis subsp. holarctica OSU18 chorismate mutase YP_762971.1 314837 D 393011 CDS YP_762972.1 115314249 4307638 315214..316029 1 NC_008369.1 CDP-diglycerine-serine O-phosphatidyltransferase; CDP-alcohol phosphatidyltransferase 316029 4307638 FTH_0327 Francisella tularensis subsp. holarctica OSU18 CDP-alcohol phosphatidyltransferase YP_762972.1 315214 D 393011 CDS YP_762973.1 115314250 4307639 complement(316034..316240) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 316240 4307639 FTH_0328 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762973.1 316034 R 393011 CDS YP_762974.1 115314251 4307640 316410..317117 1 NC_008369.1 TolQ protein 317117 tolQ 4307640 tolQ Francisella tularensis subsp. holarctica OSU18 TolQ protein YP_762974.1 316410 D 393011 CDS YP_762975.1 115314252 4307641 317127..317573 1 NC_008369.1 TolR protein 317573 tolR 4307641 tolR Francisella tularensis subsp. holarctica OSU18 TolR protein YP_762975.1 317127 D 393011 CDS YP_762976.1 115314253 4307642 317560..318471 1 NC_008369.1 hypothetical protein 318471 4307642 FTH_0331 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762976.1 317560 D 393011 CDS YP_762977.1 115314254 4307643 318483..319790 1 NC_008369.1 TolB protein 319790 tolB 4307643 tolB Francisella tularensis subsp. holarctica OSU18 TolB protein YP_762977.1 318483 D 393011 CDS YP_762978.1 115314255 4307644 319800..320045 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 320045 4307644 FTH_0333 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762978.1 319800 D 393011 CDS YP_762979.1 115314256 4307645 320064..320687 1 NC_008369.1 OmpA family protein 320687 4307645 FTH_0334 Francisella tularensis subsp. holarctica OSU18 OmpA family protein YP_762979.1 320064 D 393011 CDS YP_762980.1 115314257 4307646 320794..322089 1 NC_008369.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 322089 rimO 4307646 rimO Francisella tularensis subsp. holarctica OSU18 ribosomal protein S12 methylthiotransferase YP_762980.1 320794 D 393011 CDS YP_762981.1 115314258 4307647 322098..322448 1 NC_008369.1 GNAT family acetyltransferase 322448 4307647 FTH_0336 Francisella tularensis subsp. holarctica OSU18 GNAT family acetyltransferase YP_762981.1 322098 D 393011 CDS YP_762982.1 115314259 4307648 join(322594..322923,322923..323474) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 323474 isftu1 4307648 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_762982.1 322594 D 393011 CDS YP_762983.1 115314260 4307649 323446..323655 1 NC_008369.1 hypothetical protein 323655 4307649 FTH_0338 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762983.1 323446 D 393011 CDS YP_762984.1 115314261 4307651 325135..326664 1 NC_008369.1 deoxyribodipyrimidine photo-lyase family protein 326664 4307651 FTH_0340 Francisella tularensis subsp. holarctica OSU18 deoxyribodipyrimidine photo-lyase family protein YP_762984.1 325135 D 393011 CDS YP_762985.1 115314262 4307652 326661..326798 1 NC_008369.1 hypothetical protein 326798 4307652 FTH_0341 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762985.1 326661 D 393011 CDS YP_762986.1 115314263 4307653 326924..327856 1 NC_008369.1 BASS family bile acid:sodium (Na+) symporter 327856 4307653 FTH_0342 Francisella tularensis subsp. holarctica OSU18 BASS family bile acid:sodium (Na+) symporter YP_762986.1 326924 D 393011 CDS YP_762987.1 115314264 4307657 329844..330830 1 NC_008369.1 hypothetical protein 330830 4307657 FTH_0345 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762987.1 329844 D 393011 CDS YP_762988.1 115314265 4307659 complement(332218..332643) 1 NC_008369.1 hypothetical protein 332643 4307659 FTH_0347 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762988.1 332218 R 393011 CDS YP_762989.1 115314266 4307660 complement(join(332615..333166,333166..333495)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 333495 isftu1 4307660 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_762989.1 332615 R 393011 CDS YP_762990.1 115314267 4307661 complement(333613..333972) 1 NC_008369.1 hypothetical protein 333972 4307661 FTH_0349 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762990.1 333613 R 393011 CDS YP_762991.1 115314268 4307662 complement(333986..334840) 1 NC_008369.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; 4-hydroxybenzoate polyprenyltransferase 334840 ubiA 4307662 ubiA Francisella tularensis subsp. holarctica OSU18 4-hydroxybenzoate polyprenyltransferase YP_762991.1 333986 R 393011 CDS YP_762992.1 115314269 4307663 complement(334843..335349) 1 NC_008369.1 chorismate lyase; 4-hydroxybenzoate synthetase 335349 4307663 FTH_0351 Francisella tularensis subsp. holarctica OSU18 4-hydroxybenzoate synthetase YP_762992.1 334843 R 393011 CDS YP_762993.1 115314270 4307664 335448..336155 1 NC_008369.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 336155 rph 4307664 rph Francisella tularensis subsp. holarctica OSU18 ribonuclease PH YP_762993.1 335448 D 393011 CDS YP_762994.1 115314271 4307665 complement(336209..336532) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 336532 4307665 FTH_0353 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762994.1 336209 R 393011 CDS YP_762995.1 115314272 4307666 complement(336637..336888) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 336888 4307666 FTH_0354 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_762995.1 336637 R 393011 CDS YP_762996.1 115314273 4307667 complement(336909..337544) 1 NC_008369.1 type IV pilus assembly protein 337544 4307667 FTH_0355 Francisella tularensis subsp. holarctica OSU18 type IV pilus assembly protein YP_762996.1 336909 R 393011 CDS YP_762997.1 115314274 4307668 complement(337649..338725) 1 NC_008369.1 putative metalloprotease; heat shock protein HtpX 338725 htpX 4307668 htpX Francisella tularensis subsp. holarctica OSU18 heat shock protein HtpX YP_762997.1 337649 R 393011 CDS YP_762998.1 115314275 4307669 complement(338729..339304) 1 NC_008369.1 LemA-like protein 339304 lemA 4307669 lemA Francisella tularensis subsp. holarctica OSU18 LemA-like protein YP_762998.1 338729 R 393011 CDS YP_762999.1 115314276 4306410 complement(344458..344823) 1 NC_008369.1 arsenic resistance operon repressor 344823 arsR 4306410 arsR Francisella tularensis subsp. holarctica OSU18 arsenic resistance operon repressor YP_762999.1 344458 R 393011 CDS YP_763000.1 115314277 4306411 344966..345619 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 345619 4306411 FTH_0363 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763000.1 344966 D 393011 CDS YP_763001.1 115314278 4306412 complement(345631..345762) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 345762 4306412 FTH_0364 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763001.1 345631 R 393011 CDS YP_763002.1 115314279 4306413 345939..346937 1 NC_008369.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 346937 gpsA 4306413 gpsA Francisella tularensis subsp. holarctica OSU18 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_763002.1 345939 D 393011 CDS YP_763003.1 115314280 4306414 complement(346938..347474) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 347474 4306414 FTH_0366 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763003.1 346938 R 393011 CDS YP_763004.1 115314281 4306415 complement(347479..348849) 1 NC_008369.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 348849 radA 4306415 radA Francisella tularensis subsp. holarctica OSU18 DNA repair protein RadA YP_763004.1 347479 R 393011 CDS YP_763005.1 115314282 4306416 complement(348857..349627) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 349627 4306416 FTH_0368 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763005.1 348857 R 393011 CDS YP_763006.1 115314283 4306417 complement(349624..350223) 1 NC_008369.1 DedA family protein 350223 4306417 FTH_0369 Francisella tularensis subsp. holarctica OSU18 DedA family protein YP_763006.1 349624 R 393011 CDS YP_763007.1 115314284 4306418 complement(350226..351284) 1 NC_008369.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 351284 4306418 FTH_0370 Francisella tularensis subsp. holarctica OSU18 chorismate synthase YP_763007.1 350226 R 393011 CDS YP_763008.1 115314285 4306419 complement(351425..352078) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 352078 4306419 FTH_0371 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763008.1 351425 R 393011 CDS YP_763009.1 115314286 4306420 complement(352097..352609) 1 NC_008369.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 352609 msrB 4306420 msrB Francisella tularensis subsp. holarctica OSU18 methionine sulfoxide reductase B YP_763009.1 352097 R 393011 CDS YP_763010.1 115314287 4306421 352770..353327 1 NC_008369.1 superoxide dismuate 353327 sodC 4306421 sodC Francisella tularensis subsp. holarctica OSU18 superoxide dismuate YP_763010.1 352770 D 393011 CDS YP_763011.1 115314288 4306422 353331..354122 1 NC_008369.1 sterol desaturase 354122 4306422 FTH_0374 Francisella tularensis subsp. holarctica OSU18 sterol desaturase YP_763011.1 353331 D 393011 CDS YP_763012.1 115314289 4306423 complement(354097..355491) 1 NC_008369.1 APC family amino acid-polyamine-organocation transporter 355491 4306423 FTH_0375 Francisella tularensis subsp. holarctica OSU18 APC family amino acid-polyamine-organocation transporter YP_763012.1 354097 R 393011 CDS YP_763013.1 115314290 4306424 355641..356003 1 NC_008369.1 mannose-6-phosphate isomerase 356003 4306424 FTH_0376 Francisella tularensis subsp. holarctica OSU18 mannose-6-phosphate isomerase YP_763013.1 355641 D 393011 CDS YP_763014.1 115314291 4306426 complement(357242..358432) 1 NC_008369.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 358432 4306426 FTH_0378 Francisella tularensis subsp. holarctica OSU18 aspartate aminotransferase YP_763014.1 357242 R 393011 CDS YP_763015.1 115314292 4306427 358635..359522 1 NC_008369.1 probable cobalt (Co2+), zinc (Zn2+), cadmium (Cd2+) CDF family cation diffusion facilitator; hypothetical protein 359522 4306427 FTH_0379 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763015.1 358635 D 393011 CDS YP_763016.1 115314293 4306428 359608..361257 1 NC_008369.1 ATPase involved in DNA repair; DNA repair protein RecN 361257 recN 4306428 recN Francisella tularensis subsp. holarctica OSU18 DNA repair protein RecN YP_763016.1 359608 D 393011 CDS YP_763017.1 115314294 4306429 complement(361558..361899) 1 NC_008369.1 hypothetical protein 361899 4306429 FTH_0381 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763017.1 361558 R 393011 CDS YP_763018.1 115314295 4306432 complement(364021..364428) 1 NC_008369.1 type IV pili fiber protein 364428 4306432 FTH_0384 Francisella tularensis subsp. holarctica OSU18 type IV pili fiber protein YP_763018.1 364021 R 393011 CDS YP_763019.1 115314296 4306433 364812..365531 1 NC_008369.1 lipid A 1-phosphatase 365531 lpxE 4306433 lpxE Francisella tularensis subsp. holarctica OSU18 lipid A 1-phosphatase YP_763019.1 364812 D 393011 CDS YP_763020.1 115314297 4306434 365671..366519 1 NC_008369.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 366519 4306434 FTH_0386 Francisella tularensis subsp. holarctica OSU18 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_763020.1 365671 D 393011 CDS YP_763021.1 115314298 4306435 366739..367782 1 NC_008369.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 367782 purM 4306435 purM Francisella tularensis subsp. holarctica OSU18 phosphoribosylaminoimidazole synthetase YP_763021.1 366739 D 393011 CDS YP_763022.1 115314299 4306436 367782..370094 1 NC_008369.1 phosphoribosylaminoimidazole-succinocarboxamide synthase 370094 purC/purD 4306436 purC/purD Francisella tularensis subsp. holarctica OSU18 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_763022.1 367782 D 393011 CDS YP_763023.1 115314300 4306437 370098..370673 1 NC_008369.1 2-amino-N-ribosylacetamide 5'-phosphate transformylase; phosphoribosylglycinamide formyltransferase 370673 purN 4306437 purN Francisella tularensis subsp. holarctica OSU18 phosphoribosylglycinamide formyltransferase YP_763023.1 370098 D 393011 CDS YP_763024.1 115314301 4306438 370790..371281 1 NC_008369.1 AIR carboxylase; phosphoribosylaminoimidazole carboxylase 371281 purE 4306438 purE Francisella tularensis subsp. holarctica OSU18 phosphoribosylaminoimidazole carboxylase YP_763024.1 370790 D 393011 CDS YP_763025.1 115314302 4306439 371285..372382 1 NC_008369.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 372382 purK 4306439 purK Francisella tularensis subsp. holarctica OSU18 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_763025.1 371285 D 393011 CDS YP_763026.1 115314303 4306442 373819..374349 1 NC_008369.1 intracellular septation protein A family protein 374349 4306442 FTH_0394 Francisella tularensis subsp. holarctica OSU18 intracellular septation protein A family protein YP_763026.1 373819 D 393011 CDS YP_763027.1 115314304 4306443 374423..374674 1 NC_008369.1 hypothetical protein 374674 4306443 FTH_0395 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763027.1 374423 D 393011 CDS YP_763028.1 115314305 4306444 complement(374663..375679) 1 NC_008369.1 glucose kinase; glucokinase 375679 glk 4306444 glk Francisella tularensis subsp. holarctica OSU18 glucokinase YP_763028.1 374663 R 393011 CDS YP_763029.1 115314306 4306445 375773..376525 1 NC_008369.1 menaquinone biosynthesis methyltransferase 376525 ubiE 4306445 ubiE Francisella tularensis subsp. holarctica OSU18 menaquinone biosynthesis methyltransferase YP_763029.1 375773 D 393011 CDS YP_763030.1 115314307 4306446 376509..377114 1 NC_008369.1 hypothetical protein 377114 4306446 FTH_0398 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763030.1 376509 D 393011 CDS YP_763031.1 115314308 4306447 377107..378765 1 NC_008369.1 ubiquinone biosynthesis protein 378765 ubiB 4306447 ubiB Francisella tularensis subsp. holarctica OSU18 ubiquinone biosynthesis protein YP_763031.1 377107 D 393011 CDS YP_763032.1 115314309 4306448 378771..379109 1 NC_008369.1 HIT family histidine triad protein 379109 hitA 4306448 hitA Francisella tularensis subsp. holarctica OSU18 HIT family histidine triad protein YP_763032.1 378771 D 393011 CDS YP_763033.1 115314310 4306449 complement(379126..379257) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 379257 4306449 FTH_0401 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763033.1 379126 R 393011 CDS YP_763034.1 115314311 4306450 complement(379624..380277) 1 NC_008369.1 glutamine phosphoribosylpyrophosphate amidotransferase; amidophosphoribosyltransferase 380277 4306450 FTH_0402 Francisella tularensis subsp. holarctica OSU18 amidophosphoribosyltransferase YP_763034.1 379624 R 393011 CDS YP_763035.1 115314312 4306451 380252..381082 1 NC_008369.1 hypothetical protein 381082 4306451 FTH_0403 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763035.1 380252 D 393011 CDS YP_763036.1 115314313 4306452 complement(381084..381959) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 381959 4306452 FTH_0404 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763036.1 381084 R 393011 CDS YP_763037.1 115314314 4306453 complement(382038..382886) 1 NC_008369.1 UDP-GlcNAc-enoylpyruvate reductase; UDP-N-acetylenolpyruvoylglucosamine reductase 382886 murB 4306453 murB Francisella tularensis subsp. holarctica OSU18 UDP-N-acetylenolpyruvoylglucosamine reductase YP_763037.1 382038 R 393011 CDS YP_763038.1 115314315 4306454 complement(382894..384198) 1 NC_008369.1 enoylpyruvate transferase; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 384198 murA 4306454 murA Francisella tularensis subsp. holarctica OSU18 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_763038.1 382894 R 393011 CDS YP_763039.1 115314316 4306455 complement(384167..385564) 1 NC_008369.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 385564 engA 4306455 engA Francisella tularensis subsp. holarctica OSU18 GTP-binding protein EngA YP_763039.1 384167 R 393011 CDS YP_763040.1 115314317 4306456 complement(385801..386319) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 386319 4306456 FTH_0408 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763040.1 385801 R 393011 CDS YP_763041.1 115314318 4306459 complement(388053..388301) 1 NC_008369.1 hypothetical protein 388301 4306459 FTH_0411 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763041.1 388053 R 393011 CDS YP_763042.1 115314319 4306460 complement(388382..390388) 1 NC_008369.1 M3 family oligopeptidase A 390388 prlC 4306460 prlC Francisella tularensis subsp. holarctica OSU18 M3 family oligopeptidase A YP_763042.1 388382 R 393011 CDS YP_763043.1 115314320 4306461 390480..390851 1 NC_008369.1 hypothetical protein 390851 4306461 FTH_0413 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763043.1 390480 D 393011 CDS YP_763044.1 115314321 4306462 390932..391381 1 NC_008369.1 17 kDa lipoprotein TUL4 391381 lpnA 4306462 lpnA Francisella tularensis subsp. holarctica OSU18 17 kDa lipoprotein TUL4 YP_763044.1 390932 D 393011 CDS YP_763045.1 115314322 4306464 392042..392545 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 392545 4306464 FTH_0416 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763045.1 392042 D 393011 CDS YP_763046.1 115314323 4306465 392578..393045 1 NC_008369.1 conserved in Francisella genomes; lipoprotein 393045 lpnB 4306465 lpnB Francisella tularensis subsp. holarctica OSU18 lipoprotein YP_763046.1 392578 D 393011 CDS YP_763047.1 115314324 4306466 393118..394560 1 NC_008369.1 type IV pilus glycosylation protein 394560 4306466 FTH_0418 Francisella tularensis subsp. holarctica OSU18 type IV pilus glycosylation protein YP_763047.1 393118 D 393011 CDS YP_763048.1 115314325 4306467 complement(394614..396908) 1 NC_008369.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining; maintains net negative superhelicity; DNA topoisomerase I 396908 topA 4306467 topA Francisella tularensis subsp. holarctica OSU18 DNA topoisomerase I YP_763048.1 394614 R 393011 CDS YP_763049.1 115314326 4306468 397107..397748 1 NC_008369.1 chmomosome partition protein A 397748 parA 4306468 parA Francisella tularensis subsp. holarctica OSU18 chmomosome partition protein A YP_763049.1 397107 D 393011 CDS YP_763050.1 115314327 4306469 397741..398655 1 NC_008369.1 chromosome partition protein B 398655 parB 4306469 parB Francisella tularensis subsp. holarctica OSU18 chromosome partition protein B YP_763050.1 397741 D 393011 CDS YP_763051.1 115314328 4306470 398669..399376 1 NC_008369.1 glutamine amidotransferase 399376 guaA1 4306470 guaA1 Francisella tularensis subsp. holarctica OSU18 glutamine amidotransferase YP_763051.1 398669 D 393011 CDS YP_763052.1 115314329 4306471 399379..400260 1 NC_008369.1 hypothetical protein 400260 4306471 FTH_0423 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763052.1 399379 D 393011 CDS YP_763053.1 115314330 4306473 complement(400907..401527) 1 NC_008369.1 ribosomal large subunit methyltransferase J 401527 rrmJ 4306473 rrmJ Francisella tularensis subsp. holarctica OSU18 ribosomal large subunit methyltransferase J YP_763053.1 400907 R 393011 CDS YP_763054.1 115314331 4306474 401685..402152 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 402152 4306474 FTH_0426 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763054.1 401685 D 393011 CDS YP_763055.1 115314332 4306475 complement(402147..402632) 1 NC_008369.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 402632 lspA 4306475 lspA Francisella tularensis subsp. holarctica OSU18 lipoprotein signal peptidase YP_763055.1 402147 R 393011 CDS YP_763056.1 115314333 4306476 complement(402619..405426) 1 NC_008369.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 405426 ileS 4306476 ileS Francisella tularensis subsp. holarctica OSU18 isoleucyl-tRNA synthetase YP_763056.1 402619 R 393011 CDS YP_763057.1 115314334 4306477 complement(405519..406439) 1 NC_008369.1 flavokinase; riboflavin biosynthesis protein RibF 406439 ribF 4306477 ribF Francisella tularensis subsp. holarctica OSU18 riboflavin biosynthesis protein RibF YP_763057.1 405519 R 393011 CDS YP_763058.1 115314335 4306478 406590..408404 1 NC_008369.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 408404 maeA 4306478 maeA Francisella tularensis subsp. holarctica OSU18 malate dehydrogenase YP_763058.1 406590 D 393011 CDS YP_763059.1 115314336 4306479 408567..410240 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 410240 4306479 FTH_0431 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763059.1 408567 D 393011 CDS YP_763060.1 115314337 4306480 410257..411702 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 411702 4306480 FTH_0432 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763060.1 410257 D 393011 CDS YP_763061.1 115314338 4306483 413833..414435 1 NC_008369.1 hypothetical protein 414435 4306483 FTH_0435 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763061.1 413833 D 393011 CDS YP_763062.1 115314339 4306484 complement(414432..415736) 1 NC_008369.1 major facilitator transporter 415736 4306484 FTH_0436 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_763062.1 414432 R 393011 CDS YP_763063.1 115314340 4306485 complement(415672..417696) 1 NC_008369.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 417696 metG 4306485 metG Francisella tularensis subsp. holarctica OSU18 methionyl-tRNA synthetase YP_763063.1 415672 R 393011 CDS YP_763064.1 115314341 4306488 complement(418266..418802) 1 NC_008369.1 hypothetical protein 418802 4306488 FTH_0438 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763064.1 418266 R 393011 CDS YP_763065.1 115314342 4306494 424390..424479 1 NC_008369.1 hypothetical protein 424479 4306494 FTH_0439 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763065.1 424390 D 393011 CDS YP_763066.1 115314343 4306496 complement(425572..426480) 1 NC_008369.1 hypothetical protein 426480 4306496 FTH_0441 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763066.1 425572 R 393011 CDS YP_763067.1 115314344 4306497 complement(426745..427401) 1 NC_008369.1 M50 family peptidase 427401 4306497 FTH_0442 Francisella tularensis subsp. holarctica OSU18 M50 family peptidase YP_763067.1 426745 R 393011 CDS YP_763068.1 115314345 4306498 427463..427612 1 NC_008369.1 hypothetical protein 427612 4306498 FTH_0443 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763068.1 427463 D 393011 CDS YP_763069.1 115314346 4306499 427609..427782 1 NC_008369.1 hypothetical protein 427782 4306499 FTH_0444 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763069.1 427609 D 393011 CDS YP_763070.1 115314347 4306500 428200..428319 1 NC_008369.1 hypothetical protein 428319 4306500 FTH_0445 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763070.1 428200 D 393011 CDS YP_763071.1 115314348 4306501 428606..428941 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 428941 4306501 FTH_0446 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763071.1 428606 D 393011 CDS YP_763072.1 115314349 4306502 complement(428914..429765) 1 NC_008369.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 429765 psd 4306502 psd Francisella tularensis subsp. holarctica OSU18 phosphatidylserine decarboxylase YP_763072.1 428914 R 393011 CDS YP_763073.1 115314350 4306503 429865..430845 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 430845 4306503 FTH_0448 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763073.1 429865 D 393011 CDS YP_763074.1 115314351 4306504 430854..431897 1 NC_008369.1 NadM-Nudix subfamily; involved in creation of nicotanimide adenine dinucleotide NAD from either biosynthetic or salvage pathways; bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase 431897 4306504 FTH_0449 Francisella tularensis subsp. holarctica OSU18 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase YP_763074.1 430854 D 393011 CDS YP_763075.1 115314352 4306505 431911..433278 1 NC_008369.1 N-acetylglucosamine-1-phosphate uridyltransferase; UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase 433278 glmU 4306505 glmU Francisella tularensis subsp. holarctica OSU18 UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase YP_763075.1 431911 D 393011 CDS YP_763076.1 115314353 4306506 433299..435137 1 NC_008369.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 435137 glmS 4306506 glmS Francisella tularensis subsp. holarctica OSU18 glucosamine--fructose-6-phosphate aminotransferase YP_763076.1 433299 D 393011 CDS YP_763077.1 115314354 4306507 435221..435742 1 NC_008369.1 acetyltransferase 435742 4306507 FTH_0452 Francisella tularensis subsp. holarctica OSU18 acetyltransferase YP_763077.1 435221 D 393011 CDS YP_763078.1 115314355 4306508 complement(435739..435936) 1 NC_008369.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 435936 rpsU 4306508 rpsU Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S21 YP_763078.1 435739 R 393011 CDS YP_763079.1 115314356 4306509 complement(435936..436139) 1 NC_008369.1 cold shock protein 436139 cspC 4306509 cspC Francisella tularensis subsp. holarctica OSU18 cold shock protein YP_763079.1 435936 R 393011 CDS YP_763080.1 115314357 4306510 complement(436387..436716) 1 NC_008369.1 hypothetical protein 436716 4306510 FTH_0455 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763080.1 436387 R 393011 CDS YP_763081.1 115314358 4306511 436843..437613 1 NC_008369.1 methionine aminopeptidase 437613 map 4306511 map Francisella tularensis subsp. holarctica OSU18 methionine aminopeptidase YP_763081.1 436843 D 393011 CDS YP_763082.1 115314359 4306512 437615..438463 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 438463 4306512 FTH_0457 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763082.1 437615 D 393011 CDS YP_763083.1 115314360 4306513 438557..439222 1 NC_008369.1 hypothetical protein 439222 4306513 FTH_0458 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763083.1 438557 D 393011 CDS YP_763084.1 115314361 4306514 439355..441580 1 NC_008369.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 441580 parC 4306514 parC Francisella tularensis subsp. holarctica OSU18 DNA topoisomerase IV subunit A YP_763084.1 439355 D 393011 CDS YP_763085.1 115314362 4306515 441580..442266 1 NC_008369.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 442266 4306515 FTH_0460 Francisella tularensis subsp. holarctica OSU18 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_763085.1 441580 D 393011 CDS YP_763086.1 115314363 4306516 complement(442253..442852) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 442852 4306516 FTH_0461 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763086.1 442253 R 393011 CDS YP_763087.1 115314364 4306517 complement(442845..443963) 1 NC_008369.1 BNR/Asp-box repeat-containing protein 443963 4306517 FTH_0462 Francisella tularensis subsp. holarctica OSU18 BNR/Asp-box repeat-containing protein YP_763087.1 442845 R 393011 CDS YP_763088.1 115314365 4306518 444162..446138 1 NC_008369.1 soluble lytic murein transglycosylase 446138 slt 4306518 slt Francisella tularensis subsp. holarctica OSU18 soluble lytic murein transglycosylase YP_763088.1 444162 D 393011 CDS YP_763089.1 115314366 4306520 complement(447265..447432) 1 NC_008369.1 hypothetical protein 447432 4306520 FTH_0465 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763089.1 447265 R 393011 CDS YP_763090.1 115314367 4306521 447551..447712 1 NC_008369.1 hypothetical protein 447712 4306521 FTH_0466 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763090.1 447551 D 393011 CDS YP_763091.1 115314368 4306522 448001..448384 1 NC_008369.1 hypothetical protein 448384 4306522 FTH_0467 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763091.1 448001 D 393011 CDS YP_763092.1 115314369 4306524 449512..452991 1 NC_008369.1 DNA nucleotidyltransferase (DNA-directed); DNA polymerase III subunit alpha 452991 dnaE 4306524 dnaE Francisella tularensis subsp. holarctica OSU18 DNA polymerase III subunit alpha YP_763092.1 449512 D 393011 CDS YP_763093.1 115314370 4306525 453067..453702 1 NC_008369.1 PDF; peptide deformylase 453702 def1 4306525 def1 Francisella tularensis subsp. holarctica OSU18 peptide deformylase YP_763093.1 453067 D 393011 CDS YP_763094.1 115314371 4306527 complement(454056..454172) 1 NC_008369.1 hypothetical protein 454172 4306527 FTH_0471 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763094.1 454056 R 393011 CDS YP_763095.1 115314372 4306528 454406..455668 1 NC_008369.1 lipoprotein ABC transporter ATP-binding protein 455668 lolC 4306528 lolC Francisella tularensis subsp. holarctica OSU18 lipoprotein ABC transporter ATP-binding protein YP_763095.1 454406 D 393011 CDS YP_763096.1 115314373 4306529 455661..456356 1 NC_008369.1 lipoprotein ABC transporter binding protein 456356 lolD 4306529 lolD Francisella tularensis subsp. holarctica OSU18 lipoprotein ABC transporter binding protein YP_763096.1 455661 D 393011 CDS YP_763097.1 115314374 4306530 456473..458614 1 NC_008369.1 lysine decarboxylase 458614 cadA 4306530 cadA Francisella tularensis subsp. holarctica OSU18 lysine decarboxylase YP_763097.1 456473 D 393011 CDS YP_763098.1 115314375 4306531 458705..459781 1 NC_008369.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 459781 gcvT 4306531 gcvT Francisella tularensis subsp. holarctica OSU18 glycine cleavage system aminomethyltransferase T YP_763098.1 458705 D 393011 CDS YP_763099.1 115314376 4306532 459837..460220 1 NC_008369.1 glycine cleavage system H protein 460220 gcvH1 4306532 gcvH1 Francisella tularensis subsp. holarctica OSU18 glycine cleavage system H protein YP_763099.1 459837 D 393011 CDS YP_763100.1 115314377 4306533 460285..461652 1 NC_008369.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein; glycine dehydrogenase subunit 1 461652 gcvP1 4306533 gcvP1 Francisella tularensis subsp. holarctica OSU18 glycine dehydrogenase subunit 1 YP_763100.1 460285 D 393011 CDS YP_763101.1 115314378 4306534 461658..463103 1 NC_008369.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; glycine dehydrogenase subunit 2 463103 gcvP2 4306534 gcvP2 Francisella tularensis subsp. holarctica OSU18 glycine dehydrogenase subunit 2 YP_763101.1 461658 D 393011 CDS YP_763102.1 115314379 4306535 complement(463223..464068) 1 NC_008369.1 5-dehydroshikimate reductase; shikimate dehydrogenase 464068 aroE2 4306535 aroE2 Francisella tularensis subsp. holarctica OSU18 shikimate dehydrogenase YP_763102.1 463223 R 393011 CDS YP_763103.1 115314380 4306536 complement(464094..467306) 1 NC_008369.1 alpha-dextrin endo-1,6-alpha-glucosidase; pullulanase 467306 pul 4306536 pul Francisella tularensis subsp. holarctica OSU18 pullulanase YP_763103.1 464094 R 393011 CDS YP_763104.1 115314381 4306537 complement(467340..469262) 1 NC_008369.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 469262 glgB 4306537 glgB Francisella tularensis subsp. holarctica OSU18 glycogen branching protein YP_763104.1 467340 R 393011 CDS YP_763105.1 115314382 4306538 469564..471198 1 NC_008369.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 471198 pgm 4306538 pgm Francisella tularensis subsp. holarctica OSU18 phosphoglucomutase YP_763105.1 469564 D 393011 CDS YP_763106.1 115314383 4306539 471232..472503 1 NC_008369.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 472503 glgC 4306539 glgC Francisella tularensis subsp. holarctica OSU18 glucose-1-phosphate adenylyltransferase YP_763106.1 471232 D 393011 CDS YP_763107.1 115314384 4306540 472513..473982 1 NC_008369.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 473982 glgA 4306540 glgA Francisella tularensis subsp. holarctica OSU18 glycogen synthase YP_763107.1 472513 D 393011 CDS YP_763108.1 115314385 4306541 474087..476360 1 NC_008369.1 amylophosphorylase; phosphorylase 476360 glgP 4306541 glgP Francisella tularensis subsp. holarctica OSU18 phosphorylase YP_763108.1 474087 D 393011 CDS YP_763109.1 115314386 4306542 476326..477867 1 NC_008369.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 477867 malQ 4306542 malQ Francisella tularensis subsp. holarctica OSU18 4-alpha-glucanotransferase YP_763109.1 476326 D 393011 CDS YP_763110.1 115314387 4306543 477941..478855 1 NC_008369.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 478855 glyQ 4306543 glyQ Francisella tularensis subsp. holarctica OSU18 glycyl-tRNA synthetase subunit alpha YP_763110.1 477941 D 393011 CDS YP_763111.1 115314388 4306544 479047..480525 1 NC_008369.1 murE synthetase; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 480525 murE 4306544 murE Francisella tularensis subsp. holarctica OSU18 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_763111.1 479047 D 393011 CDS YP_763112.1 115314389 4306545 480547..480942 1 NC_008369.1 hypothetical protein 480942 4306545 FTH_0489 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763112.1 480547 D 393011 CDS YP_763113.1 115314390 4306546 481295..482653 1 NC_008369.1 UDP-N--acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase 482653 murF 4306546 murF Francisella tularensis subsp. holarctica OSU18 UDP-N--acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase YP_763113.1 481295 D 393011 CDS YP_763114.1 115314391 4306547 482662..483480 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 483480 4306547 FTH_0491 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763114.1 482662 D 393011 CDS YP_763115.1 115314392 4306551 486545..487837 1 NC_008369.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 487837 thrC 4306551 thrC Francisella tularensis subsp. holarctica OSU18 threonine synthase YP_763115.1 486545 D 393011 CDS YP_763116.1 115314393 4306553 488425..488913 1 NC_008369.1 S-adenosyl-L-methionine decarboxylase; adenosylmethionine decarboxylase 488913 speH 4306553 speH Francisella tularensis subsp. holarctica OSU18 adenosylmethionine decarboxylase YP_763116.1 488425 D 393011 CDS YP_763117.1 115314394 4306554 488913..489782 1 NC_008369.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 489782 speE 4306554 speE Francisella tularensis subsp. holarctica OSU18 spermidine synthase YP_763117.1 488913 D 393011 CDS YP_763118.1 115314395 4307594 complement(494218..494934) 1 NC_008369.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 494934 lpxH 4307594 lpxH Francisella tularensis subsp. holarctica OSU18 UDP-2,3-diacylglucosamine hydrolase YP_763118.1 494218 R 393011 CDS YP_763119.1 115314396 4307595 complement(494924..495550) 1 NC_008369.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 495550 pyrE 4307595 pyrE Francisella tularensis subsp. holarctica OSU18 orotate phosphoribosyltransferase YP_763119.1 494924 R 393011 CDS YP_763120.1 115314397 4307596 495710..497080 1 NC_008369.1 UDP-N-acetylmuramate--L-alanine ligase 497080 murC 4307596 murC Francisella tularensis subsp. holarctica OSU18 UDP-N-acetylmuramate--L-alanine ligase YP_763120.1 495710 D 393011 CDS YP_763121.1 115314398 4307597 497077..497733 1 NC_008369.1 rRNA methyltransferase 497733 4307597 FTH_0506 Francisella tularensis subsp. holarctica OSU18 rRNA methyltransferase YP_763121.1 497077 D 393011 CDS YP_763122.1 115314399 4307598 complement(join(497711..498262,498262..498591)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 498591 isftu1 4307598 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763122.1 497711 R 393011 CDS YP_763123.1 115314400 4307599 498840..499520 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 499520 4307599 FTH_0508 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763123.1 498840 D 393011 CDS YP_763124.1 115314401 4307600 complement(499800..500036) 1 NC_008369.1 transcription regulator BolA 500036 4307600 FTH_0509 Francisella tularensis subsp. holarctica OSU18 transcription regulator BolA YP_763124.1 499800 R 393011 CDS YP_763125.1 115314402 4307601 complement(500053..500346) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 500346 4307601 FTH_0510 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763125.1 500053 R 393011 CDS YP_763126.1 115314403 4307568 complement(500346..501014) 1 NC_008369.1 hypothetical protein 501014 4307568 FTH_0511 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763126.1 500346 R 393011 CDS YP_763127.1 115314404 4307569 complement(501083..501616) 1 NC_008369.1 organic solvent ABC superfamily substrate-binding protein 501616 4307569 FTH_0512 Francisella tularensis subsp. holarctica OSU18 organic solvent ABC superfamily substrate-binding protein YP_763127.1 501083 R 393011 CDS YP_763128.1 115314405 4307570 complement(501616..502380) 1 NC_008369.1 toluene ABC transporter ATP-binding/membrane protein 502380 4307570 FTH_0513 Francisella tularensis subsp. holarctica OSU18 toluene ABC transporter ATP-binding/membrane protein YP_763128.1 501616 R 393011 CDS YP_763129.1 115314406 4307571 complement(502384..503187) 1 NC_008369.1 ABC transporter ATP-binding protein 503187 4307571 FTH_0514 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_763129.1 502384 R 393011 CDS YP_763130.1 115314407 4307572 complement(503201..503473) 1 NC_008369.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 503473 minE 4307572 minE Francisella tularensis subsp. holarctica OSU18 cell division topological specificity factor MinE YP_763130.1 503201 R 393011 CDS YP_763131.1 115314408 4307573 complement(503476..504300) 1 NC_008369.1 septum site-determining protein MinD 504300 minD 4307573 minD Francisella tularensis subsp. holarctica OSU18 septum site-determining protein MinD YP_763131.1 503476 R 393011 CDS YP_763132.1 115314409 4307574 complement(504340..505026) 1 NC_008369.1 septum site-determining protein MinC 505026 minC 4307574 minC Francisella tularensis subsp. holarctica OSU18 septum site-determining protein MinC YP_763132.1 504340 R 393011 CDS YP_763133.1 115314410 4307575 complement(505061..505216) 1 NC_008369.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 505216 rpmG 4307575 rpmG Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L33 YP_763133.1 505061 R 393011 CDS YP_763134.1 115314411 4307576 complement(505243..505479) 1 NC_008369.1 required for 70S ribosome assembly; 50S ribosomal protein L28 505479 rpmB 4307576 rpmB Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L28 YP_763134.1 505243 R 393011 CDS YP_763135.1 115314412 4307577 complement(505613..505957) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 505957 4307577 FTH_0520 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763135.1 505613 R 393011 CDS YP_763136.1 115314413 4307578 506087..508126 1 NC_008369.1 ATP-dependent DNA helicase RecG 508126 recG 4307578 recG Francisella tularensis subsp. holarctica OSU18 ATP-dependent DNA helicase RecG YP_763136.1 506087 D 393011 CDS YP_763137.1 115314414 4307579 508130..508327 1 NC_008369.1 hypothetical protein 508327 4307579 FTH_0522 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763137.1 508130 D 393011 CDS YP_763138.1 115314415 4307580 508573..508674 1 NC_008369.1 hypothetical protein 508674 4307580 FTH_0523 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763138.1 508573 D 393011 CDS YP_763139.1 115314416 4307581 508881..510395 1 NC_008369.1 fumarase; fumerate hydratase 510395 fumA 4307581 fumA Francisella tularensis subsp. holarctica OSU18 fumerate hydratase YP_763139.1 508881 D 393011 CDS YP_763140.1 115314417 4307582 510399..510539 1 NC_008369.1 hypothetical protein 510539 4307582 FTH_0525 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763140.1 510399 D 393011 CDS YP_763141.1 115314418 4307586 511603..511887 1 NC_008369.1 exci/endonuclease 511887 4307586 FTH_0529 Francisella tularensis subsp. holarctica OSU18 exci/endonuclease YP_763141.1 511603 D 393011 CDS YP_763142.1 115314419 4307588 512125..514998 1 NC_008369.1 type III restriction enzyme; type III site-specific deoxyribonuclease 514998 res 4307588 res Francisella tularensis subsp. holarctica OSU18 type III site-specific deoxyribonuclease YP_763142.1 512125 D 393011 CDS YP_763143.1 115314420 4307589 514995..515657 1 NC_008369.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 515657 ung 4307589 ung Francisella tularensis subsp. holarctica OSU18 uracil-DNA glycosylase YP_763143.1 514995 D 393011 CDS YP_763144.1 115314421 4307943 complement(516809..517354) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 517354 4307943 FTH_0534 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763144.1 516809 R 393011 CDS YP_763145.1 115314422 4307944 517613..520219 1 NC_008369.1 DNA gyrase; DNA gyrase subunit A 520219 gyrA 4307944 gyrA Francisella tularensis subsp. holarctica OSU18 DNA gyrase subunit A YP_763145.1 517613 D 393011 CDS YP_763146.1 115314423 4307945 520225..521385 1 NC_008369.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 521385 dxr 4307945 dxr Francisella tularensis subsp. holarctica OSU18 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_763146.1 520225 D 393011 CDS YP_763147.1 115314424 4307946 521391..523769 1 NC_008369.1 outer membrane protein/protective antigen 523769 4307946 FTH_0537 Francisella tularensis subsp. holarctica OSU18 outer membrane protein/protective antigen YP_763147.1 521391 D 393011 CDS YP_763148.1 115314425 4307947 523905..524408 1 NC_008369.1 outer membrane protein OmpH 524408 4307947 FTH_0538 Francisella tularensis subsp. holarctica OSU18 outer membrane protein OmpH YP_763148.1 523905 D 393011 CDS YP_763149.1 115314426 4307948 524427..525440 1 NC_008369.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 525440 lpxD 4307948 lpxD Francisella tularensis subsp. holarctica OSU18 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_763149.1 524427 D 393011 CDS YP_763150.1 115314427 4307949 525455..525946 1 NC_008369.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 525946 fabZ 4307949 fabZ Francisella tularensis subsp. holarctica OSU18 (3R)-hydroxymyristoyl-ACP dehydratase YP_763150.1 525455 D 393011 CDS YP_763151.1 115314428 4307950 525949..526728 1 NC_008369.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 526728 lpxA 4307950 lpxA Francisella tularensis subsp. holarctica OSU18 UDP-N-acetylglucosamine acyltransferase YP_763151.1 525949 D 393011 CDS YP_763152.1 115314429 4307951 526728..527870 1 NC_008369.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 527870 lpxB 4307951 lpxB Francisella tularensis subsp. holarctica OSU18 lipid-A-disaccharide synthase YP_763152.1 526728 D 393011 CDS YP_763153.1 115314430 4307952 527929..528516 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 528516 4307952 FTH_0543 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763153.1 527929 D 393011 CDS YP_763154.1 115314431 4307953 528607..528981 1 NC_008369.1 hypothetical protein 528981 4307953 FTH_0544 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763154.1 528607 D 393011 CDS YP_763155.1 115314432 4307954 529388..530431 1 NC_008369.1 glycosyl hydrolase 530431 4307954 FTH_0545 Francisella tularensis subsp. holarctica OSU18 glycosyl hydrolase YP_763155.1 529388 D 393011 CDS YP_763156.1 115314433 4307956 complement(530802..531611) 1 NC_008369.1 hypothetical protein 531611 4307956 FTH_0546 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763156.1 530802 R 393011 CDS YP_763157.1 115314434 4307957 complement(531681..532445) 1 NC_008369.1 CDP-diglyceride-choline O-phosphatidyltransferase; phosphatidylcholine synthase 532445 pcs 4307957 pcs Francisella tularensis subsp. holarctica OSU18 phosphatidylcholine synthase YP_763157.1 531681 R 393011 CDS YP_763158.1 115314435 4307958 complement(532493..533374) 1 NC_008369.1 farnesyl diphosphate synthetase; geranyltranstransferase 533374 ispA 4307958 ispA Francisella tularensis subsp. holarctica OSU18 geranyltranstransferase YP_763158.1 532493 R 393011 CDS YP_763159.1 115314436 4307959 complement(533371..534666) 1 NC_008369.1 3-deoxy-D-manno-octulosonic-acid transferase KdtA; 3-deoxy-D-manno-octulosonic-acid transferase 534666 waaA 4307959 waaA Francisella tularensis subsp. holarctica OSU18 3-deoxy-D-manno-octulosonic-acid transferase YP_763159.1 533371 R 393011 CDS YP_763160.1 115314437 4307960 complement(534771..535349) 1 NC_008369.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 535349 4307960 FTH_0550 Francisella tularensis subsp. holarctica OSU18 putative deoxyribonucleotide triphosphate pyrophosphatase YP_763160.1 534771 R 393011 CDS YP_763161.1 115314438 4307961 535456..536280 1 NC_008369.1 P5CR; pyrroline-5-carboxylate reductase 536280 proC 4307961 proC Francisella tularensis subsp. holarctica OSU18 pyrroline-5-carboxylate reductase YP_763161.1 535456 D 393011 CDS YP_763162.1 115314439 4307963 538038..538724 1 NC_008369.1 two-component response regulator 538724 4307963 FTH_0553 Francisella tularensis subsp. holarctica OSU18 two-component response regulator YP_763162.1 538038 D 393011 CDS YP_763163.1 115314440 4307964 538729..539592 1 NC_008369.1 bacterial leader peptidase I; signal peptidase I 539592 lepB 4307964 lepB Francisella tularensis subsp. holarctica OSU18 signal peptidase I YP_763163.1 538729 D 393011 CDS YP_763164.1 115314441 4307965 539599..540291 1 NC_008369.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 540291 rnc 4307965 rnc Francisella tularensis subsp. holarctica OSU18 ribonuclease III YP_763164.1 539599 D 393011 CDS YP_763165.1 115314442 4307966 540278..541186 1 NC_008369.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 541186 truB 4307966 truB Francisella tularensis subsp. holarctica OSU18 tRNA pseudouridine synthase B YP_763165.1 540278 D 393011 CDS YP_763166.1 115314443 4307967 541179..543431 1 NC_008369.1 VacB; ribonuclease R 543431 rnr 4307967 rnr Francisella tularensis subsp. holarctica OSU18 ribonuclease R YP_763166.1 541179 D 393011 CDS YP_763167.1 115314444 4307969 complement(544342..545085) 1 NC_008369.1 oxidoreductase 545085 4307969 FTH_0559 Francisella tularensis subsp. holarctica OSU18 oxidoreductase YP_763167.1 544342 R 393011 CDS YP_763168.1 115314445 4307970 complement(545087..545629) 1 NC_008369.1 hypothetical protein 545629 4307970 FTH_0560 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763168.1 545087 R 393011 CDS YP_763169.1 115314446 4307971 complement(545626..546171) 1 NC_008369.1 hypothetical protein 546171 4307971 FTH_0561 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763169.1 545626 R 393011 CDS YP_763170.1 115314447 4307972 complement(546128..547222) 1 NC_008369.1 CFA synthase; cyclopropane-fatty-acyl-phospholipid synthase 547222 cfa 4307972 cfa Francisella tularensis subsp. holarctica OSU18 cyclopropane-fatty-acyl-phospholipid synthase YP_763170.1 546128 R 393011 CDS YP_763171.1 115314448 4307973 complement(547409..547591) 1 NC_008369.1 hypothetical protein 547591 4307973 FTH_0563 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763171.1 547409 R 393011 CDS YP_763172.1 115314449 4307974 complement(547678..548184) 1 NC_008369.1 hypothetical protein 548184 4307974 FTH_0564 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763172.1 547678 R 393011 CDS YP_763173.1 115314450 4307975 complement(548178..549233) 1 NC_008369.1 oxidase 549233 4307975 FTH_0565 Francisella tularensis subsp. holarctica OSU18 oxidase YP_763173.1 548178 R 393011 CDS YP_763174.1 115314451 4307977 complement(550017..550358) 1 NC_008369.1 hypothetical protein 550358 4307977 FTH_0567 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763174.1 550017 R 393011 CDS YP_763175.1 115314452 4308073 552009..552545 1 NC_008369.1 outer membrane protein 26; conserved in Francisella genomes; hypothetical protein 552545 4308073 FTH_0570 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763175.1 552009 D 393011 CDS YP_763176.1 115314453 4308074 552663..553064 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 553064 4308074 FTH_0571 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763176.1 552663 D 393011 CDS YP_763177.1 115314454 4308075 553239..553847 1 NC_008369.1 hypothetical protein 553847 4308075 FTH_0572 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763177.1 553239 D 393011 CDS YP_763178.1 115314455 4308076 553904..555334 1 NC_008369.1 hypothetical protein 555334 4308076 FTH_0573 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763178.1 553904 D 393011 CDS YP_763179.1 115314456 4308077 555345..556328 1 NC_008369.1 hypothetical protein 556328 4308077 FTH_0574 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763179.1 555345 D 393011 CDS YP_763180.1 115314457 4308078 556334..557728 1 NC_008369.1 hypothetical protein 557728 4308078 FTH_0575 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763180.1 556334 D 393011 CDS YP_763181.1 115314458 4308082 560975..562390 1 NC_008369.1 niacin ribonucleotidase; putative nicotinate phosphoribosyltransferase 562390 pncB 4308082 pncB Francisella tularensis subsp. holarctica OSU18 putative nicotinate phosphoribosyltransferase YP_763181.1 560975 D 393011 CDS YP_763182.1 115314459 4308083 562475..562702 1 NC_008369.1 hypothetical protein 562702 4308083 FTH_0580 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763182.1 562475 D 393011 CDS YP_763183.1 115314460 4308084 562852..564132 1 NC_008369.1 major facilitator transporter 564132 4308084 FTH_0581 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_763183.1 562852 D 393011 CDS YP_763184.1 115314461 4308085 complement(564125..564613) 1 NC_008369.1 hypothetical protein 564613 4308085 FTH_0582 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763184.1 564125 R 393011 CDS YP_763185.1 115314462 4308086 complement(564675..565862) 1 NC_008369.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 565862 fadA 4308086 fadA Francisella tularensis subsp. holarctica OSU18 acetyl-CoA acetyltransferase YP_763185.1 564675 R 393011 CDS YP_763186.1 115314463 4308087 complement(565875..568571) 1 NC_008369.1 beta-hydroxyacyl dehydrogenase; bifunctional 3-hydroxacyl-CoA dehydrogenase/acyl-CoA-binding protein 568571 fadB/acbP 4308087 fadB/acbP Francisella tularensis subsp. holarctica OSU18 bifunctional 3-hydroxacyl-CoA dehydrogenase/acyl-CoA-binding protein YP_763186.1 565875 R 393011 CDS YP_763187.2 162139939 4308088 complement(568644..570884) 1 NC_008369.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 570884 fadE 4308088 fadE Francisella tularensis subsp. holarctica OSU18 acyl-CoA dehydrogenase YP_763187.2 568644 R 393011 CDS YP_763188.1 115314465 4308089 complement(570922..572610) 1 NC_008369.1 acyl-activating enzyme; long-chain-fatty-acid--CoA ligase 572610 fadD1 4308089 fadD1 Francisella tularensis subsp. holarctica OSU18 long-chain-fatty-acid--CoA ligase YP_763188.1 570922 R 393011 CDS YP_763189.1 115314466 4308090 572826..573173 1 NC_008369.1 arsenate reductase 573173 arsC2 4308090 arsC2 Francisella tularensis subsp. holarctica OSU18 arsenate reductase YP_763189.1 572826 D 393011 CDS YP_763190.1 115314467 4308091 573195..575438 1 NC_008369.1 dual-cofactor-specific isocitrate dehydrogenase; isocitrate dehydrogenase 575438 4308091 FTH_0588 Francisella tularensis subsp. holarctica OSU18 isocitrate dehydrogenase YP_763190.1 573195 D 393011 CDS YP_763191.1 115314468 4308092 575452..576339 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 576339 4308092 FTH_0589 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763191.1 575452 D 393011 CDS YP_763192.1 115314469 4308093 576359..580693 1 NC_008369.1 ATP-dependent helicase HrpA 580693 hrpA 4308093 hrpA Francisella tularensis subsp. holarctica OSU18 ATP-dependent helicase HrpA YP_763192.1 576359 D 393011 CDS YP_763193.1 115314470 4308095 581948..583684 1 NC_008369.1 dTDP-glucose 4,6-dehydratase 583684 4308095 FTH_0592 Francisella tularensis subsp. holarctica OSU18 dTDP-glucose 4,6-dehydratase YP_763193.1 581948 D 393011 CDS YP_763194.1 115314471 4308096 583677..584309 1 NC_008369.1 galactosyltransferase 584309 4308096 FTH_0593 Francisella tularensis subsp. holarctica OSU18 galactosyltransferase YP_763194.1 583677 D 393011 CDS YP_763195.1 115314472 4308097 584311..585102 1 NC_008369.1 galactowaldenase; UDP-glucose 4-epimerase 585102 4308097 FTH_0594 Francisella tularensis subsp. holarctica OSU18 UDP-glucose 4-epimerase YP_763195.1 584311 D 393011 CDS YP_763196.1 115314473 4308098 585092..586183 1 NC_008369.1 galacturonosyltransferase 586183 4308098 FTH_0595 Francisella tularensis subsp. holarctica OSU18 galacturonosyltransferase YP_763196.1 585092 D 393011 CDS YP_763197.1 115314474 4308099 586201..587511 1 NC_008369.1 UDP-N-acetyl-D-mannosaminuronate dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase 587511 wecC 4308099 wecC Francisella tularensis subsp. holarctica OSU18 UDP-glucose/GDP-mannose dehydrogenase YP_763197.1 586201 D 393011 CDS YP_763198.1 115314475 4308100 587499..588482 1 NC_008369.1 galactowaldenase; UDP-glucose 4-epimerase 588482 4308100 FTH_0597 Francisella tularensis subsp. holarctica OSU18 UDP-glucose 4-epimerase YP_763198.1 587499 D 393011 CDS YP_763199.1 115314476 4308101 588499..589728 1 NC_008369.1 O-antigen polymerase 589728 wzy 4308101 wzy Francisella tularensis subsp. holarctica OSU18 O-antigen polymerase YP_763199.1 588499 D 393011 CDS YP_763200.1 115314477 4308102 589725..590825 1 NC_008369.1 glycosyltransferase 590825 4308102 FTH_0599 Francisella tularensis subsp. holarctica OSU18 glycosyltransferase YP_763200.1 589725 D 393011 CDS YP_763201.1 115314478 4308103 590825..592711 1 NC_008369.1 asparagine synthetase (glutamine-hydrolyzing); asparagine synthase 592711 asnB 4308103 asnB Francisella tularensis subsp. holarctica OSU18 asparagine synthase YP_763201.1 590825 D 393011 CDS YP_763202.1 115314479 4308104 592704..593786 1 NC_008369.1 pyridoxal phosphate-dependent sugar transaminase; ECA biosynthesis protein 593786 wecE 4308104 wecE Francisella tularensis subsp. holarctica OSU18 ECA biosynthesis protein YP_763202.1 592704 D 393011 CDS YP_763203.1 115314480 4308105 593783..594508 1 NC_008369.1 hypothetical protein 594508 4308105 FTH_0602 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763203.1 593783 D 393011 CDS YP_763204.1 115314481 4308106 594513..596000 1 NC_008369.1 O-antigen transporter; PST family polysaccharide transporter 596000 4308106 FTH_0603 Francisella tularensis subsp. holarctica OSU18 PST family polysaccharide transporter YP_763204.1 594513 D 393011 CDS YP_763205.1 115314482 4308107 595993..596853 1 NC_008369.1 glycosyltransferase 596853 4308107 FTH_0604 Francisella tularensis subsp. holarctica OSU18 glycosyltransferase YP_763205.1 595993 D 393011 CDS YP_763206.1 115314483 4308108 596878..597762 1 NC_008369.1 dTDP-glucose diphosphorylase; glucose-1-phosphate thymidylyltransferase 597762 4308108 FTH_0605 Francisella tularensis subsp. holarctica OSU18 glucose-1-phosphate thymidylyltransferase YP_763206.1 596878 D 393011 CDS YP_763207.1 115314484 4308112 600574..601980 1 NC_008369.1 GDP-mannose phosphorylase; mannose-1-phosphate guanylyltransferase (GDP) 601980 manC 4308112 manC Francisella tularensis subsp. holarctica OSU18 mannose-1-phosphate guanylyltransferase (GDP) YP_763207.1 600574 D 393011 CDS YP_763208.1 115314485 4308113 602011..603495 1 NC_008369.1 phosphomannose mutase; phosphomannomutase 603495 manB 4308113 manB Francisella tularensis subsp. holarctica OSU18 phosphomannomutase YP_763208.1 602011 D 393011 CDS YP_763209.1 115314486 4308114 complement(604588..605850) 1 NC_008369.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 605850 rho 4308114 rho Francisella tularensis subsp. holarctica OSU18 transcription termination factor Rho YP_763209.1 604588 R 393011 CDS YP_763210.1 115314487 4308115 complement(605893..606216) 1 NC_008369.1 thioredoxin 606216 trxA1 4308115 trxA1 Francisella tularensis subsp. holarctica OSU18 thioredoxin YP_763210.1 605893 R 393011 CDS YP_763211.1 115314488 4308116 606405..607340 1 NC_008369.1 exopolypase; exopolyphosphatase 607340 ppx 4308116 ppx Francisella tularensis subsp. holarctica OSU18 exopolyphosphatase YP_763211.1 606405 D 393011 CDS YP_763212.1 115314489 4308118 608225..608341 1 NC_008369.1 hypothetical protein 608341 4308118 FTH_0615 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763212.1 608225 D 393011 CDS YP_763213.1 115314490 4308119 complement(608500..608685) 1 NC_008369.1 hypothetical protein 608685 4308119 FTH_0616 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763213.1 608500 R 393011 CDS YP_763214.1 115314491 4308120 608777..609679 1 NC_008369.1 recombination factor protein RarA 609679 4308120 FTH_0617 Francisella tularensis subsp. holarctica OSU18 recombination factor protein RarA YP_763214.1 608777 D 393011 CDS YP_763215.1 115314492 4308121 609767..610720 1 NC_008369.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 610720 rpoA2 4308121 rpoA2 Francisella tularensis subsp. holarctica OSU18 DNA-directed RNA polymerase subunit alpha YP_763215.1 609767 D 393011 CDS YP_763216.1 115314493 4308123 complement(610916..611065) 1 NC_008369.1 hypothetical protein 611065 4308123 FTH_0619 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763216.1 610916 R 393011 CDS YP_763217.1 115314494 4308124 complement(611339..611824) 1 NC_008369.1 bacterioferritin 611824 4308124 FTH_0620 Francisella tularensis subsp. holarctica OSU18 bacterioferritin YP_763217.1 611339 R 393011 CDS YP_763218.1 115314495 4308126 613273..613401 1 NC_008369.1 hypothetical protein 613401 4308126 FTH_0622 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763218.1 613273 D 393011 CDS YP_763219.1 115314496 4308127 613484..614251 1 NC_008369.1 magnesium (Mg2+)-dependent deoxyribonuclease 614251 tatD 4308127 tatD Francisella tularensis subsp. holarctica OSU18 magnesium (Mg2+)-dependent deoxyribonuclease YP_763219.1 613484 D 393011 CDS YP_763220.1 115314497 4308128 614377..615477 1 NC_008369.1 hypothetical protein 615477 4308128 FTH_0624 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763220.1 614377 D 393011 CDS YP_763221.1 115314498 4308130 616436..617359 1 NC_008369.1 multidrug ABC transporter ATP-binding protein 617359 4308130 FTH_0626 Francisella tularensis subsp. holarctica OSU18 multidrug ABC transporter ATP-binding protein YP_763221.1 616436 D 393011 CDS YP_763222.1 115314499 4308131 617368..618147 1 NC_008369.1 multidrug ABC transporter membrane protein 618147 4308131 FTH_0627 Francisella tularensis subsp. holarctica OSU18 multidrug ABC transporter membrane protein YP_763222.1 617368 D 393011 CDS YP_763223.1 115314500 4308132 complement(618151..619095) 1 NC_008369.1 glycosyl transferase family protein 619095 4308132 FTH_0628 Francisella tularensis subsp. holarctica OSU18 glycosyl transferase family protein YP_763223.1 618151 R 393011 CDS YP_763224.1 115314501 4308133 619286..620176 1 NC_008369.1 DPN kinase; NAD(+) kinase 620176 ppnK 4308133 ppnK Francisella tularensis subsp. holarctica OSU18 NAD(+) kinase YP_763224.1 619286 D 393011 CDS YP_763225.1 115314502 4308134 complement(620173..620808) 1 NC_008369.1 homoserine/threonine resistance transporter 620808 4308134 FTH_0630 Francisella tularensis subsp. holarctica OSU18 homoserine/threonine resistance transporter YP_763225.1 620173 R 393011 CDS YP_763226.1 115314503 4308135 620878..621567 1 NC_008369.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 621567 trmB 4308135 trmB Francisella tularensis subsp. holarctica OSU18 tRNA (guanine-N(7)-)-methyltransferase YP_763226.1 620878 D 393011 CDS YP_763227.1 115314504 4308136 621577..622293 1 NC_008369.1 hypothetical protein 622293 4308136 FTH_0632 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763227.1 621577 D 393011 CDS YP_763228.1 115314505 4308139 623903..624202 1 NC_008369.1 transcriptional regulator 624202 4308139 FTH_0635 Francisella tularensis subsp. holarctica OSU18 transcriptional regulator YP_763228.1 623903 D 393011 CDS YP_763229.1 115314506 4308140 624268..624771 1 NC_008369.1 rhodanese sulfurtransferase family protein 624771 4308140 FTH_0636 Francisella tularensis subsp. holarctica OSU18 rhodanese sulfurtransferase family protein YP_763229.1 624268 D 393011 CDS YP_763230.1 115314507 4308142 626530..627234 1 NC_008369.1 metal-dependent hydrolase 627234 4308142 FTH_0638 Francisella tularensis subsp. holarctica OSU18 metal-dependent hydrolase YP_763230.1 626530 D 393011 CDS YP_763231.1 115314508 4308143 627236..627985 1 NC_008369.1 hypothetical protein 627985 4308143 FTH_0639 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763231.1 627236 D 393011 CDS YP_763232.1 115314509 4308144 complement(627978..628598) 1 NC_008369.1 proline hydroxylase 628598 4308144 FTH_0640 Francisella tularensis subsp. holarctica OSU18 proline hydroxylase YP_763232.1 627978 R 393011 CDS YP_763233.1 115314510 4308145 complement(628638..629087) 1 NC_008369.1 hypothetical protein 629087 4308145 FTH_0641 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763233.1 628638 R 393011 CDS YP_763234.1 115314511 4308146 complement(629318..629818) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 629818 4308146 FTH_0642 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763234.1 629318 R 393011 CDS YP_763235.1 115314512 4308148 630412..630837 1 NC_008369.1 N utilization substance protein B 630837 nusB 4308148 nusB Francisella tularensis subsp. holarctica OSU18 N utilization substance protein B YP_763235.1 630412 D 393011 CDS YP_763236.1 115314513 4308149 complement(630821..631606) 1 NC_008369.1 aminohydrolase 631606 4308149 FTH_0645 Francisella tularensis subsp. holarctica OSU18 aminohydrolase YP_763236.1 630821 R 393011 CDS YP_763237.1 115314514 4308150 631760..632173 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 632173 4308150 FTH_0646 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763237.1 631760 D 393011 CDS YP_763238.1 115314515 4308151 complement(632319..633128) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 633128 4308151 FTH_0647 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763238.1 632319 R 393011 CDS YP_763239.1 115314516 4308152 complement(633236..633718) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 633718 4308152 FTH_0648 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763239.1 633236 R 393011 CDS YP_763240.1 115314517 4308154 complement(634996..636693) 1 NC_008369.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 636693 proS 4308154 proS Francisella tularensis subsp. holarctica OSU18 prolyl-tRNA synthetase YP_763240.1 634996 R 393011 CDS YP_763241.1 115314518 4308156 complement(638723..638950) 1 NC_008369.1 hypothetical protein 638950 4308156 FTH_0652 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763241.1 638723 R 393011 CDS YP_763242.1 115314519 4308157 complement(638953..639087) 1 NC_008369.1 hypothetical protein 639087 4308157 FTH_0653 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763242.1 638953 R 393011 CDS YP_763243.1 115314520 4308158 complement(639277..639807) 1 NC_008369.1 hypothetical protein 639807 4308158 FTH_0654 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763243.1 639277 R 393011 CDS YP_763244.1 115314521 4308159 complement(639809..639979) 1 NC_008369.1 hypothetical protein 639979 4308159 FTH_0655 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763244.1 639809 R 393011 CDS YP_763245.1 115314522 4308161 640505..640921 1 NC_008369.1 SufE family Fe-S protein 640921 4308161 FTH_0656 Francisella tularensis subsp. holarctica OSU18 SufE family Fe-S protein YP_763245.1 640505 D 393011 CDS YP_763246.1 115314523 4308162 640922..641671 1 NC_008369.1 hydroxymethylbilane hydrolyase (cyclizing); uroporphyrinogen-III synthase 641671 hemD 4308162 hemD Francisella tularensis subsp. holarctica OSU18 uroporphyrinogen-III synthase YP_763246.1 640922 D 393011 CDS YP_763247.1 115314524 4308163 641637..642722 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 642722 4308163 FTH_0658 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763247.1 641637 D 393011 CDS YP_763248.1 115314525 4308164 642719..643876 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 643876 4308164 FTH_0659 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763248.1 642719 D 393011 CDS YP_763249.1 115314526 4308165 643890..644648 1 NC_008369.1 glyoxalase II; hydroxyacylglutathione hydrolase 644648 gloB 4308165 gloB Francisella tularensis subsp. holarctica OSU18 hydroxyacylglutathione hydrolase YP_763249.1 643890 D 393011 CDS YP_763250.1 115314527 4308166 complement(644726..645433) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 645433 4308166 FTH_0661 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763250.1 644726 R 393011 CDS YP_763251.1 115314528 4308167 645542..645766 1 NC_008369.1 iron (Fe2+) transport protein A 645766 feoA 4308167 feoA Francisella tularensis subsp. holarctica OSU18 iron (Fe2+) transport protein A YP_763251.1 645542 D 393011 CDS YP_763252.1 115314529 4308168 645783..647417 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 647417 4308168 FTH_0663 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763252.1 645783 D 393011 CDS YP_763253.1 115314530 4308172 complement(647989..648654) 1 NC_008369.1 prophage repressor protein 648654 4308172 FTH_0664 Francisella tularensis subsp. holarctica OSU18 prophage repressor protein YP_763253.1 647989 R 393011 CDS YP_763254.1 115314531 4308173 648811..649179 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 649179 4308173 FTH_0665 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763254.1 648811 D 393011 CDS YP_763255.1 115314532 4308174 complement(649210..650082) 1 NC_008369.1 hypothetical protein 650082 4308174 FTH_0666 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763255.1 649210 R 393011 CDS YP_763256.1 115314533 4308175 650259..651845 1 NC_008369.1 glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase; glutamate synthase 651845 gltB 4308175 gltB Francisella tularensis subsp. holarctica OSU18 glutamate synthase YP_763256.1 650259 D 393011 CDS YP_763257.1 115314534 4308176 651925..655164 1 NC_008369.1 similar to Escherichia coli exonuclease V; exodeoxyribonuclease V 655164 recC 4308176 recC Francisella tularensis subsp. holarctica OSU18 exodeoxyribonuclease V YP_763257.1 651925 D 393011 CDS YP_763258.1 115314535 4308177 655106..655678 1 NC_008369.1 hypothetical protein 655678 4308177 FTH_0669 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763258.1 655106 D 393011 CDS YP_763259.1 115314536 4308178 655710..655805 1 NC_008369.1 hypothetical protein 655805 4308178 FTH_0670 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763259.1 655710 D 393011 CDS YP_763260.1 115314537 4308179 655821..657272 1 NC_008369.1 ATP-dependent DNA helicase 657272 4308179 FTH_0671 Francisella tularensis subsp. holarctica OSU18 ATP-dependent DNA helicase YP_763260.1 655821 D 393011 CDS YP_763261.1 115314538 4308180 657344..660997 1 NC_008369.1 similar to Escherichia coli exonuclease V; exodeoxyribonuclease V 660997 recB 4308180 recB Francisella tularensis subsp. holarctica OSU18 exodeoxyribonuclease V YP_763261.1 657344 D 393011 CDS YP_763262.1 115314539 4308181 660963..662831 1 NC_008369.1 similar to Escherichia coli exonuclease V; exodeoxyribonuclease V 662831 recD 4308181 recD Francisella tularensis subsp. holarctica OSU18 exodeoxyribonuclease V YP_763262.1 660963 D 393011 CDS YP_763263.1 115314540 4308182 complement(662840..663610) 1 NC_008369.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 663610 4308182 FTH_0674 Francisella tularensis subsp. holarctica OSU18 pantothenate kinase YP_763263.1 662840 R 393011 CDS YP_763264.1 115314541 4308183 complement(663614..663949) 1 NC_008369.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 663949 panD 4308183 panD Francisella tularensis subsp. holarctica OSU18 aspartate alpha-decarboxylase YP_763264.1 663614 R 393011 CDS YP_763265.1 115314542 4308184 complement(663943..664776) 1 NC_008369.1 pantoate activating enzyme; pantoate--beta-alanine ligase 664776 panC 4308184 panC Francisella tularensis subsp. holarctica OSU18 pantoate--beta-alanine ligase YP_763265.1 663943 R 393011 CDS YP_763266.1 115314543 4308185 complement(664715..665581) 1 NC_008369.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 665581 panB 4308185 panB Francisella tularensis subsp. holarctica OSU18 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_763266.1 664715 R 393011 CDS YP_763267.1 115314544 4308186 complement(665514..666227) 1 NC_008369.1 hypothetical protein 666227 4308186 FTH_0678 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763267.1 665514 R 393011 CDS YP_763268.1 115314545 4308187 666535..668571 1 NC_008369.1 DNA joinase; DNA ligase 668571 ligN 4308187 ligN Francisella tularensis subsp. holarctica OSU18 DNA ligase YP_763268.1 666535 D 393011 CDS YP_763269.1 115314546 4308189 complement(669999..670805) 1 NC_008369.1 polyamine ABC transporter ATP-binding protein 670805 potC 4308189 potC Francisella tularensis subsp. holarctica OSU18 polyamine ABC transporter ATP-binding protein YP_763269.1 669999 R 393011 CDS YP_763270.1 115314547 4308190 complement(670819..671736) 1 NC_008369.1 polyamine ABC transporter ATP-binding protein 671736 potB 4308190 potB Francisella tularensis subsp. holarctica OSU18 polyamine ABC transporter ATP-binding protein YP_763270.1 670819 R 393011 CDS YP_763271.1 115314548 4308191 complement(671700..672821) 1 NC_008369.1 polyamine ABC transporter ATP-binding protein 672821 potA 4308191 potA Francisella tularensis subsp. holarctica OSU18 polyamine ABC transporter ATP-binding protein YP_763271.1 671700 R 393011 CDS YP_763272.1 115314549 4308194 complement(674726..675148) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 675148 4308194 FTH_0686 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763272.1 674726 R 393011 CDS YP_763273.1 115314550 4308195 complement(675252..676001) 1 NC_008369.1 NAD(+) synthetase (glutamine-hydrolyzing); NAD(+) synthase 676001 nadE 4308195 nadE Francisella tularensis subsp. holarctica OSU18 NAD(+) synthase YP_763273.1 675252 R 393011 CDS YP_763274.1 115314551 4308196 complement(676130..677602) 1 NC_008369.1 outer membrane efflux protein 677602 4308196 FTH_0688 Francisella tularensis subsp. holarctica OSU18 outer membrane efflux protein YP_763274.1 676130 R 393011 CDS YP_763275.1 115314552 4308197 complement(677612..678634) 1 NC_008369.1 multidrug resistance efflux pump 678634 4308197 FTH_0689 Francisella tularensis subsp. holarctica OSU18 multidrug resistance efflux pump YP_763275.1 677612 R 393011 CDS YP_763276.1 115314553 4308198 complement(678656..680185) 1 NC_008369.1 possible multidrug efflux transporter; major facilitator transporter 680185 4308198 FTH_0690 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_763276.1 678656 R 393011 CDS YP_763277.1 115314554 4308199 680329..681177 1 NC_008369.1 AraC family transcription regulator 681177 4308199 FTH_0691 Francisella tularensis subsp. holarctica OSU18 AraC family transcription regulator YP_763277.1 680329 D 393011 CDS YP_763278.1 115314555 4308200 complement(681165..682856) 1 NC_008369.1 acyl-activating enzyme; long-chain-fatty-acid--CoA ligase 682856 caiC 4308200 caiC Francisella tularensis subsp. holarctica OSU18 long-chain-fatty-acid--CoA ligase YP_763278.1 681165 R 393011 CDS YP_763279.1 115314556 4308201 complement(682964..684451) 1 NC_008369.1 POT family proton (H+)-dependent oligopeptide transporter 684451 4308201 FTH_0693 Francisella tularensis subsp. holarctica OSU18 POT family proton (H+)-dependent oligopeptide transporter YP_763279.1 682964 R 393011 CDS YP_763280.1 115314557 4308202 complement(684681..685409) 1 NC_008369.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 685409 4308202 FTH_0694 Francisella tularensis subsp. holarctica OSU18 16S ribosomal RNA methyltransferase RsmE YP_763280.1 684681 R 393011 CDS YP_763281.1 115314558 4308203 685480..686166 1 NC_008369.1 hypothetical protein 686166 4308203 FTH_0695 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763281.1 685480 D 393011 CDS YP_763282.1 115314559 4308204 complement(686156..686854) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 686854 4308204 FTH_0696 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763282.1 686156 R 393011 CDS YP_763283.1 115314560 4308205 complement(686859..687584) 1 NC_008369.1 mycobacterial cell entry protein (mce); ABC transporter ATP-binding protein 687584 4308205 FTH_0697 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_763283.1 686859 R 393011 CDS YP_763284.1 115314561 4308206 complement(687594..688355) 1 NC_008369.1 ABC transporter ATP-binding protein 688355 4308206 FTH_0698 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_763284.1 687594 R 393011 CDS YP_763285.1 115314562 4308207 complement(688370..689470) 1 NC_008369.1 ABC transporter ATP-binding protein 689470 4308207 FTH_0699 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_763285.1 688370 R 393011 CDS YP_763286.1 115314563 4308208 complement(689545..690393) 1 NC_008369.1 hypothetical protein 690393 4308208 FTH_0700 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763286.1 689545 R 393011 CDS YP_763287.1 115314564 4308209 complement(690335..691333) 1 NC_008369.1 pseudouridine synthase; pseudouridylate synthase 691333 rluD 4308209 rluD Francisella tularensis subsp. holarctica OSU18 pseudouridylate synthase YP_763287.1 690335 R 393011 CDS YP_763288.1 115314565 4308210 691421..692245 1 NC_008369.1 hypothetical protein 692245 4308210 FTH_0702 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763288.1 691421 D 393011 CDS YP_763289.1 115314566 4308211 692322..694121 1 NC_008369.1 FAD-binding protein 694121 4308211 FTH_0703 Francisella tularensis subsp. holarctica OSU18 FAD-binding protein YP_763289.1 692322 D 393011 CDS YP_763290.1 115314567 4308213 complement(695922..697175) 1 NC_008369.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 697175 glyA 4308213 glyA Francisella tularensis subsp. holarctica OSU18 serine hydroxymethyltransferase YP_763290.1 695922 R 393011 CDS YP_763291.1 115314568 4308214 697279..697827 1 NC_008369.1 hypothetical protein 697827 4308214 FTH_0706 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763291.1 697279 D 393011 CDS YP_763292.1 115314569 4308215 complement(697842..699113) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 699113 4308215 FTH_0707 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763292.1 697842 R 393011 CDS YP_763293.1 115314570 4308216 complement(699299..699520) 1 NC_008369.1 hypothetical protein 699520 4308216 FTH_0708 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763293.1 699299 R 393011 CDS YP_763294.1 115314571 4308217 699513..700652 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 700652 4308217 FTH_0709 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763294.1 699513 D 393011 CDS YP_763295.1 115314572 4308218 complement(700678..701568) 1 NC_008369.1 glycosyltransferase 701568 4308218 FTH_0710 Francisella tularensis subsp. holarctica OSU18 glycosyltransferase YP_763295.1 700678 R 393011 CDS YP_763296.1 115314573 4308219 complement(701576..702664) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 702664 4308219 FTH_0711 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763296.1 701576 R 393011 CDS YP_763297.1 115314574 4308220 702834..703898 1 NC_008369.1 glycosyltransferase 703898 4308220 FTH_0712 Francisella tularensis subsp. holarctica OSU18 glycosyltransferase YP_763297.1 702834 D 393011 CDS YP_763298.1 115314575 4308221 complement(703975..704928) 1 NC_008369.1 choloylglycine family hydrolase 704928 4308221 FTH_0713 Francisella tularensis subsp. holarctica OSU18 choloylglycine family hydrolase YP_763298.1 703975 R 393011 CDS YP_763299.1 115314576 4308223 complement(706625..707821) 1 NC_008369.1 PP-loop superfamily ATPase 707821 mesJ 4308223 mesJ Francisella tularensis subsp. holarctica OSU18 PP-loop superfamily ATPase YP_763299.1 706625 R 393011 CDS YP_763300.1 115314577 4308224 complement(707822..709066) 1 NC_008369.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 709066 serA 4308224 serA Francisella tularensis subsp. holarctica OSU18 D-3-phosphoglycerate dehydrogenase YP_763300.1 707822 R 393011 CDS YP_763301.1 115314578 4308225 complement(709069..709893) 1 NC_008369.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 709893 thyA 4308225 thyA Francisella tularensis subsp. holarctica OSU18 thymidylate synthase YP_763301.1 709069 R 393011 CDS YP_763302.1 115314579 4308226 complement(709878..710684) 1 NC_008369.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 710684 lgt 4308226 lgt Francisella tularensis subsp. holarctica OSU18 prolipoprotein diacylglyceryl transferase YP_763302.1 709878 R 393011 CDS YP_763303.1 115314580 4308227 complement(710699..713230) 1 NC_008369.1 ribonuclease E 713230 cafA1 4308227 cafA1 Francisella tularensis subsp. holarctica OSU18 ribonuclease E YP_763303.1 710699 R 393011 CDS YP_763304.1 115314581 4308228 713480..714655 1 NC_008369.1 cysteine desulfarase 714655 iscS 4308228 iscS Francisella tularensis subsp. holarctica OSU18 cysteine desulfarase YP_763304.1 713480 D 393011 CDS YP_763305.1 115314582 4308229 714648..714977 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 714977 4308229 FTH_0721 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763305.1 714648 D 393011 CDS YP_763306.1 115314583 4308230 714961..715659 1 NC_008369.1 DNA repair protein RecO 715659 recO 4308230 recO Francisella tularensis subsp. holarctica OSU18 DNA repair protein RecO YP_763306.1 714961 D 393011 CDS YP_763307.1 115314584 4308231 complement(715735..716382) 1 NC_008369.1 DedA family protein 716382 dedA1 4308231 dedA1 Francisella tularensis subsp. holarctica OSU18 DedA family protein YP_763307.1 715735 R 393011 CDS YP_763308.1 115314585 4308232 complement(716438..717064) 1 NC_008369.1 DedA family protein 717064 dedA2 4308232 dedA2 Francisella tularensis subsp. holarctica OSU18 DedA family protein YP_763308.1 716438 R 393011 CDS YP_763309.1 115314586 4308233 complement(717071..717337) 1 NC_008369.1 hypothetical protein 717337 4308233 FTH_0725 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763309.1 717071 R 393011 CDS YP_763310.1 115314587 4308234 complement(717340..717888) 1 NC_008369.1 5,10-methenyltetrahydrofolate synthetase; 5-formyltetrahydrofolate cyclo-ligase 717888 4308234 FTH_0726 Francisella tularensis subsp. holarctica OSU18 5-formyltetrahydrofolate cyclo-ligase YP_763310.1 717340 R 393011 CDS YP_763311.1 115314588 4308235 718328..718864 1 NC_008369.1 hypothetical protein 718864 4308235 FTH_0727 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763311.1 718328 D 393011 CDS YP_763312.1 115314589 4308236 718873..720084 1 NC_008369.1 2-octaprenyl-6-methoxyphenyl hydroxylase 720084 ubiH 4308236 ubiH Francisella tularensis subsp. holarctica OSU18 2-octaprenyl-6-methoxyphenyl hydroxylase YP_763312.1 718873 D 393011 CDS YP_763313.1 115314590 4308237 720074..721309 1 NC_008369.1 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 721309 4308237 FTH_0729 Francisella tularensis subsp. holarctica OSU18 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase YP_763313.1 720074 D 393011 CDS YP_763314.1 115314591 4308238 721331..721792 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 721792 4308238 FTH_0730 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763314.1 721331 D 393011 CDS YP_763315.1 115314592 4308239 721812..722834 1 NC_008369.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 722834 queA 4308239 queA Francisella tularensis subsp. holarctica OSU18 S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_763315.1 721812 D 393011 CDS YP_763316.1 115314593 4308240 723469..724260 1 NC_008369.1 HAD superfamily haloacid dehalogenase hydrolase 724260 4308240 FTH_0732 Francisella tularensis subsp. holarctica OSU18 HAD superfamily haloacid dehalogenase hydrolase YP_763316.1 723469 D 393011 CDS YP_763317.1 115314594 4308241 complement(724514..725227) 1 NC_008369.1 hypothetical protein 725227 4308241 FTH_0733 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763317.1 724514 R 393011 CDS YP_763318.1 115314595 4308242 725343..725726 1 NC_008369.1 aldoketomutase; lactoylglutathione lyase 725726 gloA 4308242 gloA Francisella tularensis subsp. holarctica OSU18 lactoylglutathione lyase YP_763318.1 725343 D 393011 CDS YP_763319.1 115314596 4308244 join(726180..726509,726509..727060) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 727060 isftu1 4308244 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763319.1 726180 D 393011 CDS YP_763320.1 115314597 4308246 complement(729038..729763) 1 NC_008369.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 729763 rpiA 4308246 rpiA Francisella tularensis subsp. holarctica OSU18 ribose-5-phosphate isomerase A YP_763320.1 729038 R 393011 CDS YP_763321.1 115314598 4308247 complement(729714..731084) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 731084 4308247 FTH_0739 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763321.1 729714 R 393011 CDS YP_763322.1 115314599 4308248 complement(731098..731490) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 731490 4308248 FTH_0740 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763322.1 731098 R 393011 CDS YP_763323.1 115314600 4308249 complement(731502..733385) 1 NC_008369.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 733385 gidA 4308249 gidA Francisella tularensis subsp. holarctica OSU18 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_763323.1 731502 R 393011 CDS YP_763324.1 115314601 4308250 733528..734610 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 734610 4308250 FTH_0742 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763324.1 733528 D 393011 CDS YP_763325.1 115314602 4308251 734597..735502 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 735502 4308251 FTH_0743 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763325.1 734597 D 393011 CDS YP_763326.1 115314603 4308253 736528..737250 1 NC_008369.1 short chain dehydrogenase 737250 4308253 FTH_0745 Francisella tularensis subsp. holarctica OSU18 short chain dehydrogenase YP_763326.1 736528 D 393011 CDS YP_763327.1 115314604 4308254 737384..738832 1 NC_008369.1 similar to Escherichia coli exonuclease I; exodeoxyribonuclease I 738832 sbcB 4308254 sbcB Francisella tularensis subsp. holarctica OSU18 exodeoxyribonuclease I YP_763327.1 737384 D 393011 CDS YP_763328.1 115314605 4308255 738834..740840 1 NC_008369.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 740840 uvrB 4308255 uvrB Francisella tularensis subsp. holarctica OSU18 excinuclease ABC subunit B YP_763328.1 738834 D 393011 CDS YP_763329.1 115314606 4308256 740844..741674 1 NC_008369.1 hypothetical protein 741674 4308256 FTH_0748 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763329.1 740844 D 393011 CDS YP_763330.1 115314607 4308257 741674..742471 1 NC_008369.1 glutamate racemase 742471 murI 4308257 murI Francisella tularensis subsp. holarctica OSU18 glutamate racemase YP_763330.1 741674 D 393011 CDS YP_763331.1 115314608 4308258 742562..743839 1 NC_008369.1 major facilitator transporter 743839 4308258 FTH_0750 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_763331.1 742562 D 393011 CDS YP_763332.1 115314609 4308261 746372..747298 1 NC_008369.1 hypothetical protein 747298 4308261 FTH_0753 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763332.1 746372 D 393011 CDS YP_763333.1 115314610 4308262 747315..747827 1 NC_008369.1 hypothetical protein 747827 4308262 FTH_0754 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763333.1 747315 D 393011 CDS YP_763334.1 115314611 4308263 748009..749067 1 NC_008369.1 transglutaminase 749067 4308263 FTH_0755 Francisella tularensis subsp. holarctica OSU18 transglutaminase YP_763334.1 748009 D 393011 CDS YP_763335.1 115314612 4308265 750430..751815 1 NC_008369.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 751815 xseA 4308265 xseA Francisella tularensis subsp. holarctica OSU18 exodeoxyribonuclease VII large subunit YP_763335.1 750430 D 393011 CDS YP_763336.1 115314613 4308266 751799..751999 1 NC_008369.1 hypothetical protein 751999 4308266 FTH_0758 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763336.1 751799 D 393011 CDS YP_763337.1 115314614 4308268 complement(753612..754223) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 754223 4308268 FTH_0760 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763337.1 753612 R 393011 CDS YP_763338.1 115314615 4308269 complement(754490..755245) 1 NC_008369.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 755245 4308269 FTH_0761 Francisella tularensis subsp. holarctica OSU18 C32 tRNA thiolase YP_763338.1 754490 R 393011 CDS YP_763339.1 115314616 4308270 complement(755246..755719) 1 NC_008369.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 755719 smpB 4308270 smpB Francisella tularensis subsp. holarctica OSU18 SsrA-binding protein YP_763339.1 755246 R 393011 CDS YP_763340.1 115314617 4306877 755794..756225 1 NC_008369.1 hypothetical protein 756225 4306877 FTH_0763 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763340.1 755794 D 393011 CDS YP_763341.1 115314618 4306878 756225..756530 1 NC_008369.1 hypothetical protein 756530 4306878 FTH_0764 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763341.1 756225 D 393011 CDS YP_763342.1 115314619 4306879 756572..757777 1 NC_008369.1 glycine/D-amino acid oxidase 757777 4306879 FTH_0765 Francisella tularensis subsp. holarctica OSU18 glycine/D-amino acid oxidase YP_763342.1 756572 D 393011 CDS YP_763343.1 115314620 4306880 757812..758774 1 NC_008369.1 lipoprotein VacJ 758774 vacJ 4306880 vacJ Francisella tularensis subsp. holarctica OSU18 lipoprotein VacJ YP_763343.1 757812 D 393011 CDS YP_763344.1 115314621 4306881 758829..760634 1 NC_008369.1 gamma-glutamyltranspeptidase; gamma-glutamyltransferase 760634 ggt 4306881 ggt Francisella tularensis subsp. holarctica OSU18 gamma-glutamyltransferase YP_763344.1 758829 D 393011 CDS YP_763345.1 115314622 4306882 complement(760650..761402) 1 NC_008369.1 hypothetical protein 761402 4306882 FTH_0768 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763345.1 760650 R 393011 CDS YP_763346.1 115314623 4306883 complement(761574..763391) 1 NC_008369.1 GTP binding translational elongation factor Tu and G family protein 763391 typA 4306883 typA Francisella tularensis subsp. holarctica OSU18 GTP binding translational elongation factor Tu and G family protein YP_763346.1 761574 R 393011 CDS YP_763347.1 115314624 4306884 763811..765364 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 765364 4306884 FTH_0770 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763347.1 763811 D 393011 CDS YP_763348.1 115314625 4306886 767843..768613 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 768613 4306886 FTH_0772 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763348.1 767843 D 393011 CDS YP_763349.1 115314626 4306887 768683..768892 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 768892 4306887 FTH_0773 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763349.1 768683 D 393011 CDS YP_763350.1 115314627 4306891 complement(join(772124..772675,772675..773004)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 773004 isftu1 4306891 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763350.1 772124 R 393011 CDS YP_763351.1 115314628 4306892 complement(773234..774982) 1 NC_008369.1 lipoprotein 774982 4306892 FTH_0778 Francisella tularensis subsp. holarctica OSU18 lipoprotein YP_763351.1 773234 R 393011 CDS YP_763352.1 115314629 4306893 complement(775049..775921) 1 NC_008369.1 GTP-binding protein 775921 4306893 FTH_0779 Francisella tularensis subsp. holarctica OSU18 GTP-binding protein YP_763352.1 775049 R 393011 CDS YP_763353.1 115314630 4306894 775984..777117 1 NC_008369.1 L-glutamine amidohydrolase; N-acetylglucosamine-6-phosphate deacetylase 777117 nagA 4306894 nagA Francisella tularensis subsp. holarctica OSU18 N-acetylglucosamine-6-phosphate deacetylase YP_763353.1 775984 D 393011 CDS YP_763354.1 115314631 4306895 777121..777759 1 NC_008369.1 M22 family peptidase 777759 4306895 FTH_0781 Francisella tularensis subsp. holarctica OSU18 M22 family peptidase YP_763354.1 777121 D 393011 CDS YP_763355.1 115314632 4306896 777763..778569 1 NC_008369.1 glutamine amidotransferase; GMP synthase 778569 4306896 FTH_0782 Francisella tularensis subsp. holarctica OSU18 GMP synthase YP_763355.1 777763 D 393011 CDS YP_763356.1 115314633 4306897 778579..779772 1 NC_008369.1 aspartate aminotransferase; aspartate transaminase 779772 aat 4306897 aat Francisella tularensis subsp. holarctica OSU18 aspartate transaminase YP_763356.1 778579 D 393011 CDS YP_763357.1 115314634 4306898 779886..780779 1 NC_008369.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 780779 era 4306898 era Francisella tularensis subsp. holarctica OSU18 GTP-binding protein Era YP_763357.1 779886 D 393011 CDS YP_763358.1 115314635 4306899 780946..781209 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 781209 4306899 FTH_0785 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763358.1 780946 D 393011 CDS YP_763359.1 115314636 4306901 784188..784367 1 NC_008369.1 hypothetical protein 784367 4306901 FTH_0787 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763359.1 784188 D 393011 CDS YP_763360.1 115314637 4306902 complement(784549..785205) 1 NC_008369.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 785205 adk 4306902 adk Francisella tularensis subsp. holarctica OSU18 adenylate kinase YP_763360.1 784549 R 393011 CDS YP_763361.1 115314638 4306903 785332..786336 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 786336 4306903 FTH_0789 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763361.1 785332 D 393011 CDS YP_763362.1 115314639 4306904 786338..786901 1 NC_008369.1 Type IV pili associated protein 786901 pilN 4306904 pilN Francisella tularensis subsp. holarctica OSU18 Type IV pili associated protein YP_763362.1 786338 D 393011 CDS YP_763363.1 115314640 4306905 786895..787491 1 NC_008369.1 type IV pilus glycosylase 787491 4306905 FTH_0791 Francisella tularensis subsp. holarctica OSU18 type IV pilus glycosylase YP_763363.1 786895 D 393011 CDS YP_763364.1 115314641 4306906 787497..788087 1 NC_008369.1 type IV pilus assembly protein 788087 4306906 FTH_0792 Francisella tularensis subsp. holarctica OSU18 type IV pilus assembly protein YP_763364.1 787497 D 393011 CDS YP_763365.1 115314642 4306907 788100..789872 1 NC_008369.1 type IV pilus assembly protein 789872 pilQ 4306907 pilQ Francisella tularensis subsp. holarctica OSU18 type IV pilus assembly protein YP_763365.1 788100 D 393011 CDS YP_763366.1 115314643 4306908 789998..790528 1 NC_008369.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 790528 aroK 4306908 aroK Francisella tularensis subsp. holarctica OSU18 shikimate kinase I YP_763366.1 789998 D 393011 CDS YP_763367.1 115314644 4306909 790525..791604 1 NC_008369.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 791604 aroB 4306909 aroB Francisella tularensis subsp. holarctica OSU18 3-dehydroquinate synthase YP_763367.1 790525 D 393011 CDS YP_763368.1 115314645 4306910 791662..791787 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 791787 4306910 FTH_0796 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763368.1 791662 D 393011 CDS YP_763369.1 115314646 4306911 complement(791953..792336) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 792336 4306911 FTH_0797 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763369.1 791953 R 393011 CDS YP_763370.1 115314647 4306912 792550..792837 1 NC_008369.1 hypothetical protein 792837 4306912 FTH_0798 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763370.1 792550 D 393011 CDS YP_763371.1 115314648 4306913 792845..796918 1 NC_008369.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 796918 putA 4306913 putA Francisella tularensis subsp. holarctica OSU18 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_763371.1 792845 D 393011 CDS YP_763372.1 115314649 4306914 797078..798586 1 NC_008369.1 APC family amino acid-polyamine-organocation transporter 798586 4306914 FTH_0800 Francisella tularensis subsp. holarctica OSU18 APC family amino acid-polyamine-organocation transporter YP_763372.1 797078 D 393011 CDS YP_763373.1 115314650 4306915 798662..799846 1 NC_008369.1 major facilitator transporter 799846 4306915 FTH_0801 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_763373.1 798662 D 393011 CDS YP_763374.1 115314651 4306916 799859..801034 1 NC_008369.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase 801034 dfp 4306916 dfp Francisella tularensis subsp. holarctica OSU18 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase YP_763374.1 799859 D 393011 CDS YP_763375.1 115314652 4306918 complement(802118..802348) 1 NC_008369.1 cation transport regulator 802348 chaB 4306918 chaB Francisella tularensis subsp. holarctica OSU18 cation transport regulator YP_763375.1 802118 R 393011 CDS YP_763376.1 115314653 4306920 complement(803407..803613) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 803613 4306920 FTH_0806 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763376.1 803407 R 393011 CDS YP_763377.1 115314654 4306921 complement(803722..804165) 1 NC_008369.1 hypothetical protein 804165 4306921 FTH_0807 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763377.1 803722 R 393011 CDS YP_763378.1 115314655 4306922 804251..804508 1 NC_008369.1 hypothetical protein 804508 4306922 FTH_0808 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763378.1 804251 D 393011 CDS YP_763379.1 115314656 4306924 805426..805554 1 NC_008369.1 hypothetical protein 805554 4306924 FTH_0810 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763379.1 805426 D 393011 CDS YP_763380.1 115314657 4306927 complement(807886..808887) 1 NC_008369.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 808887 hemH 4306927 hemH Francisella tularensis subsp. holarctica OSU18 ferrochelatase YP_763380.1 807886 R 393011 CDS YP_763381.1 115314658 4306928 809021..809281 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 809281 4306928 FTH_0814 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763381.1 809021 D 393011 CDS YP_763382.1 115314659 4306929 809298..809633 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 809633 4306929 FTH_0815 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763382.1 809298 D 393011 CDS YP_763383.1 115314660 4306931 complement(810879..812108) 1 NC_008369.1 Type IV pili polytopic inner membrane protein 812108 pilC 4306931 pilC Francisella tularensis subsp. holarctica OSU18 Type IV pili polytopic inner membrane protein YP_763383.1 810879 R 393011 CDS YP_763384.1 115314661 4306932 complement(812123..813904) 1 NC_008369.1 type IV pilus assembly protein 813904 pilB 4306932 pilB Francisella tularensis subsp. holarctica OSU18 type IV pilus assembly protein YP_763384.1 812123 R 393011 CDS YP_763385.1 115314662 4306933 814062..814814 1 NC_008369.1 glycerophosphoryl diester phosphodiesterase 814814 glpQ 4306933 glpQ Francisella tularensis subsp. holarctica OSU18 glycerophosphoryl diester phosphodiesterase YP_763385.1 814062 D 393011 CDS YP_763386.1 115314663 4306934 complement(814803..815546) 1 NC_008369.1 competence/damage inducible protein CinA 815546 cinA 4306934 cinA Francisella tularensis subsp. holarctica OSU18 competence/damage inducible protein CinA YP_763386.1 814803 R 393011 CDS YP_763387.1 115314664 4306935 815670..818492 1 NC_008369.1 catalyze the formation of cyanophycin which may act to store excess nitrogen; cyanophycin synthetase 818492 cphA 4306935 cphA Francisella tularensis subsp. holarctica OSU18 cyanophycin synthetase YP_763387.1 815670 D 393011 CDS YP_763388.1 115314665 4306936 818518..820203 1 NC_008369.1 tetrahydrofolylpolyglutamate synthase 820203 4306936 FTH_0822 Francisella tularensis subsp. holarctica OSU18 tetrahydrofolylpolyglutamate synthase YP_763388.1 818518 D 393011 CDS YP_763389.1 115314666 4306937 complement(820208..820687) 1 NC_008369.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 820687 ispF 4306937 ispF Francisella tularensis subsp. holarctica OSU18 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_763389.1 820208 R 393011 CDS YP_763390.1 115314667 4306938 complement(820700..821458) 1 NC_008369.1 rhodanese domain-containing protein 821458 4306938 FTH_0824 Francisella tularensis subsp. holarctica OSU18 rhodanese domain-containing protein YP_763390.1 820700 R 393011 CDS YP_763391.1 115314668 4306940 complement(822715..824187) 1 NC_008369.1 D-methionine ABC transporter membrane/binding protein 824187 metIQ 4306940 metIQ Francisella tularensis subsp. holarctica OSU18 D-methionine ABC transporter membrane/binding protein YP_763391.1 822715 R 393011 CDS YP_763392.1 115314669 4306941 complement(824165..825217) 1 NC_008369.1 D-methionine ABC transporter ATP-binding protein 825217 metN 4306941 metN Francisella tularensis subsp. holarctica OSU18 D-methionine ABC transporter ATP-binding protein YP_763392.1 824165 R 393011 CDS YP_763393.1 115314670 4306942 complement(825204..825818) 1 NC_008369.1 hypothetical protein 825818 4306942 FTH_0828 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763393.1 825204 R 393011 CDS YP_763394.1 115314671 4306945 828211..829314 1 NC_008369.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 829314 tgt 4306945 tgt Francisella tularensis subsp. holarctica OSU18 queuine tRNA-ribosyltransferase YP_763394.1 828211 D 393011 CDS YP_763395.1 115314672 4306948 831189..831761 1 NC_008369.1 isochorismatase hydrolase family protein 831761 4306948 FTH_0834 Francisella tularensis subsp. holarctica OSU18 isochorismatase hydrolase family protein YP_763395.1 831189 D 393011 CDS YP_763396.1 115314673 4306949 831856..832053 1 NC_008369.1 hypothetical protein 832053 4306949 FTH_0835 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763396.1 831856 D 393011 CDS YP_763397.1 115314674 4306950 832316..832672 1 NC_008369.1 preprotein translocase subunit 832672 4306950 FTH_0836 Francisella tularensis subsp. holarctica OSU18 preprotein translocase subunit YP_763397.1 832316 D 393011 CDS YP_763398.1 115314675 4306951 832729..834666 1 NC_008369.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 834666 secD 4306951 secD Francisella tularensis subsp. holarctica OSU18 preprotein translocase subunit SecD YP_763398.1 832729 D 393011 CDS YP_763399.1 115314676 4306952 834685..835629 1 NC_008369.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 835629 secF 4306952 secF Francisella tularensis subsp. holarctica OSU18 preprotein translocase subunit SecF YP_763399.1 834685 D 393011 CDS YP_763400.1 115314677 4306953 835661..836191 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 836191 4306953 FTH_0839 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763400.1 835661 D 393011 CDS YP_763401.1 115314678 4306954 836215..837093 1 NC_008369.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 837093 rpoH 4306954 rpoH Francisella tularensis subsp. holarctica OSU18 RNA polymerase factor sigma-32 YP_763401.1 836215 D 393011 CDS YP_763402.1 115314679 4306955 837184..838461 1 NC_008369.1 3-enol-pyruvoylshikimate-5-phosphate synthase; 3-phosphoshikimate 1-carboxyvinyltransferase 838461 aroA 4306955 aroA Francisella tularensis subsp. holarctica OSU18 3-phosphoshikimate 1-carboxyvinyltransferase YP_763402.1 837184 D 393011 CDS YP_763403.1 115314680 4306956 838464..839054 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 839054 4306956 FTH_0842 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763403.1 838464 D 393011 CDS YP_763404.1 115314681 4306957 839029..839487 1 NC_008369.1 endoribonuclease H; ribonuclease H 839487 rnhA 4306957 rnhA Francisella tularensis subsp. holarctica OSU18 ribonuclease H YP_763404.1 839029 D 393011 CDS YP_763405.1 115314682 4306958 839489..840526 1 NC_008369.1 L-asparaginase 840526 ansA 4306958 ansA Francisella tularensis subsp. holarctica OSU18 L-asparaginase YP_763405.1 839489 D 393011 CDS YP_763406.1 115314683 4306959 840597..841283 1 NC_008369.1 carbonic anhydrase 841283 4306959 FTH_0845 Francisella tularensis subsp. holarctica OSU18 carbonic anhydrase YP_763406.1 840597 D 393011 CDS YP_763407.1 115314684 4306960 complement(841570..842175) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 842175 4306960 FTH_0846 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763407.1 841570 R 393011 CDS YP_763408.1 115314685 4306961 complement(842239..843111) 1 NC_008369.1 1-aminocyclopropane carboxylic acid deaminase; hypothetical protein 843111 4306961 FTH_0847 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763408.1 842239 R 393011 CDS YP_763409.1 115314686 4306962 complement(843120..843290) 1 NC_008369.1 rubredoxin 843290 4306962 FTH_0848 Francisella tularensis subsp. holarctica OSU18 rubredoxin YP_763409.1 843120 R 393011 CDS YP_763410.1 115314687 4306965 complement(846388..847662) 1 NC_008369.1 DAACS family dicarboxylate/amino acid:sodium or proton symporter 847662 4306965 FTH_0851 Francisella tularensis subsp. holarctica OSU18 DAACS family dicarboxylate/amino acid:sodium or proton symporter YP_763410.1 846388 R 393011 CDS YP_763411.1 115314688 4306966 847864..848892 1 NC_008369.1 phosphosugar isomerase 848892 4306966 FTH_0852 Francisella tularensis subsp. holarctica OSU18 phosphosugar isomerase YP_763411.1 847864 D 393011 CDS YP_763412.1 115314689 4306967 848917..850320 1 NC_008369.1 possible sugar transporter; major facilitator transporter 850320 4306967 FTH_0853 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_763412.1 848917 D 393011 CDS YP_763413.1 115314690 4306968 850475..850594 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 850594 4306968 FTH_0854 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763413.1 850475 D 393011 CDS YP_763414.1 115314691 4306970 complement(851198..852655) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 852655 4306970 FTH_0856 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763414.1 851198 R 393011 CDS YP_763415.1 115314692 4306975 856076..857293 1 NC_008369.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 857293 ispG 4306975 ispG Francisella tularensis subsp. holarctica OSU18 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_763415.1 856076 D 393011 CDS YP_763416.1 115314693 4306976 857308..858015 1 NC_008369.1 hypothetical protein 858015 4306976 FTH_0862 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763416.1 857308 D 393011 CDS YP_763417.1 115314694 4306977 858034..859827 1 NC_008369.1 M24 family aminopeptidase 859827 4306977 FTH_0863 Francisella tularensis subsp. holarctica OSU18 M24 family aminopeptidase YP_763417.1 858034 D 393011 CDS YP_763418.1 115314695 4306978 859925..860989 1 NC_008369.1 endonuclease 860989 4306978 FTH_0864 Francisella tularensis subsp. holarctica OSU18 endonuclease YP_763418.1 859925 D 393011 CDS YP_763419.1 115314696 4306979 complement(860980..861843) 1 NC_008369.1 cephalosporinase; beta-lactamase 861843 bla 4306979 bla Francisella tularensis subsp. holarctica OSU18 beta-lactamase YP_763419.1 860980 R 393011 CDS YP_763420.1 115314697 4306980 862272..863222 1 NC_008369.1 hypothetical protein 863222 4306980 FTH_0866 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763420.1 862272 D 393011 CDS YP_763421.1 115314698 4306982 complement(864039..865529) 1 NC_008369.1 apolipoprotein N-acyltransferase 865529 4306982 FTH_0868 Francisella tularensis subsp. holarctica OSU18 apolipoprotein N-acyltransferase YP_763421.1 864039 R 393011 CDS YP_763422.1 115314699 4306983 complement(865529..866371) 1 NC_008369.1 HCC family HlyC/CorC transporter 866371 4306983 FTH_0869 Francisella tularensis subsp. holarctica OSU18 HCC family HlyC/CorC transporter YP_763422.1 865529 R 393011 CDS YP_763423.1 115314700 4306984 complement(866361..866849) 1 NC_008369.1 hypothetical protein 866849 4306984 FTH_0870 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763423.1 866361 R 393011 CDS YP_763424.1 115314701 4306985 complement(866842..867825) 1 NC_008369.1 phosphate starvation-inducible protein PhoH 867825 phoH 4306985 phoH Francisella tularensis subsp. holarctica OSU18 phosphate starvation-inducible protein PhoH YP_763424.1 866842 R 393011 CDS YP_763425.1 115314702 4306986 complement(867829..869157) 1 NC_008369.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 869157 miaB 4306986 miaB Francisella tularensis subsp. holarctica OSU18 (dimethylallyl)adenosine tRNA methylthiotransferase YP_763425.1 867829 R 393011 CDS YP_763426.1 115314703 4306987 869380..870054 1 NC_008369.1 o-methyltransferase family protein 870054 4306987 FTH_0873 Francisella tularensis subsp. holarctica OSU18 o-methyltransferase family protein YP_763426.1 869380 D 393011 CDS YP_763427.1 115314704 4306989 870822..871415 1 NC_008369.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 871415 tdk 4306989 tdk Francisella tularensis subsp. holarctica OSU18 thymidine kinase YP_763427.1 870822 D 393011 CDS YP_763428.1 115314705 4306990 872078..873394 1 NC_008369.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 873394 tig 4306990 tig Francisella tularensis subsp. holarctica OSU18 trigger factor YP_763428.1 872078 D 393011 CDS YP_763429.1 115314706 4306991 873420..874025 1 NC_008369.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 874025 clpP 4306991 clpP Francisella tularensis subsp. holarctica OSU18 ATP-dependent Clp protease proteolytic subunit YP_763429.1 873420 D 393011 CDS YP_763430.1 115314707 4306992 874049..875302 1 NC_008369.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 875302 clpX 4306992 clpX Francisella tularensis subsp. holarctica OSU18 ATP-dependent protease ATP-binding subunit ClpX YP_763430.1 874049 D 393011 CDS YP_763431.1 115314708 4306993 875327..877651 1 NC_008369.1 ATP-dependent protease La; DNA-binding, ATP-dependent protease La 877651 lon 4306993 lon Francisella tularensis subsp. holarctica OSU18 DNA-binding, ATP-dependent protease La YP_763431.1 875327 D 393011 CDS YP_763432.1 115314709 4306994 877738..878010 1 NC_008369.1 histone-like protein HU form B; DNA-binding protein HU-beta 878010 4306994 FTH_0880 Francisella tularensis subsp. holarctica OSU18 DNA-binding protein HU-beta YP_763432.1 877738 D 393011 CDS YP_763433.1 115314710 4306995 878123..879556 1 NC_008369.1 hypothetical protein 879556 4306995 FTH_0881 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763433.1 878123 D 393011 CDS YP_763434.1 115314711 4306996 879557..880483 1 NC_008369.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 880483 miaA 4306996 miaA Francisella tularensis subsp. holarctica OSU18 tRNA delta(2)-isopentenylpyrophosphate transferase YP_763434.1 879557 D 393011 CDS YP_763435.1 115314712 4306997 880594..880923 1 NC_008369.1 host factor I for bacteriophage Q beta replication 880923 hfq 4306997 hfq Francisella tularensis subsp. holarctica OSU18 host factor I for bacteriophage Q beta replication YP_763435.1 880594 D 393011 CDS YP_763436.1 115314713 4306998 880975..882282 1 NC_008369.1 protease, GTP-binding subunit 882282 hflX 4306998 hflX Francisella tularensis subsp. holarctica OSU18 protease, GTP-binding subunit YP_763436.1 880975 D 393011 CDS YP_763437.1 115314714 4307000 883655..884722 1 NC_008369.1 membrane protease subunit HflK 884722 hflK 4307000 hflK Francisella tularensis subsp. holarctica OSU18 membrane protease subunit HflK YP_763437.1 883655 D 393011 CDS YP_763438.1 115314715 4307001 884724..885650 1 NC_008369.1 membrane protease subunit HflC 885650 hflC 4307001 hflC Francisella tularensis subsp. holarctica OSU18 membrane protease subunit HflC YP_763438.1 884724 D 393011 CDS YP_763439.1 115314716 4307002 885651..886136 1 NC_008369.1 phosphotyrosine phosphatase; low molecular weight (LMW) phosphotyrosine protein phosphatase 886136 wzb 4307002 wzb Francisella tularensis subsp. holarctica OSU18 low molecular weight (LMW) phosphotyrosine protein phosphatase YP_763439.1 885651 D 393011 CDS YP_763440.1 115314717 4307003 886133..886726 1 NC_008369.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 886726 engB 4307003 engB Francisella tularensis subsp. holarctica OSU18 ribosome biogenesis GTP-binding protein YsxC YP_763440.1 886133 D 393011 CDS YP_763441.1 115314718 4307005 888164..888514 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 888514 4307005 FTH_0891 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763441.1 888164 D 393011 CDS YP_763442.1 115314719 4307006 888556..888666 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 888666 4307006 FTH_0892 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763442.1 888556 D 393011 CDS YP_763443.1 115314720 4307009 891774..892091 1 NC_008369.1 acetohydroxy acid synthetase; acetolactate synthase 892091 ilvH 4307009 ilvH Francisella tularensis subsp. holarctica OSU18 acetolactate synthase YP_763443.1 891774 D 393011 CDS YP_763444.1 115314721 4307010 892119..893162 1 NC_008369.1 acetohydroxy acid isomeroreductase; ketol-acid reductoisomerase 893162 ilvC 4307010 ilvC Francisella tularensis subsp. holarctica OSU18 ketol-acid reductoisomerase YP_763444.1 892119 D 393011 CDS YP_763445.1 115314722 4307011 complement(893285..896710) 1 NC_008369.1 superfamily II helicase; transcription-repair coupling factor 896710 mfd 4307011 mfd Francisella tularensis subsp. holarctica OSU18 transcription-repair coupling factor YP_763445.1 893285 R 393011 CDS YP_763446.1 115314723 4307012 complement(896755..897441) 1 NC_008369.1 TEGT family gene transfer transporter 897441 4307012 FTH_0898 Francisella tularensis subsp. holarctica OSU18 TEGT family gene transfer transporter YP_763446.1 896755 R 393011 CDS YP_763447.1 115314724 4307013 complement(897557..898816) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 898816 4307013 FTH_0899 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763447.1 897557 R 393011 CDS YP_763448.1 115314725 4307014 complement(898816..899247) 1 NC_008369.1 hypothetical protein 899247 4307014 FTH_0900 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763448.1 898816 R 393011 CDS YP_763449.1 115314726 4307015 complement(899228..899884) 1 NC_008369.1 AP endonuclease class I; DNA-(apurinic or apyrimidinic site) lyase 899884 nth 4307015 nth Francisella tularensis subsp. holarctica OSU18 DNA-(apurinic or apyrimidinic site) lyase YP_763449.1 899228 R 393011 CDS YP_763450.1 115314727 4307016 complement(899877..900506) 1 NC_008369.1 NADH:ubiquinone oxidoreductase subunit RnfB 900506 rnfB 4307016 rnfB Francisella tularensis subsp. holarctica OSU18 NADH:ubiquinone oxidoreductase subunit RnfB YP_763450.1 899877 R 393011 CDS YP_763451.1 115314728 4307017 complement(900508..901152) 1 NC_008369.1 cofactor involved in the reduction of disulfides; glutaredoxin 901152 grxB 4307017 grxB Francisella tularensis subsp. holarctica OSU18 glutaredoxin YP_763451.1 900508 R 393011 CDS YP_763452.1 115314729 4307019 complement(902784..903284) 1 NC_008369.1 ferritin protein 903284 ftnA 4307019 ftnA Francisella tularensis subsp. holarctica OSU18 ferritin protein YP_763452.1 902784 R 393011 CDS YP_763453.1 115314730 4307020 903490..904473 1 NC_008369.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 904473 lipA 4307020 lipA Francisella tularensis subsp. holarctica OSU18 lipoyl synthase YP_763453.1 903490 D 393011 CDS YP_763454.1 115314731 4307021 904503..905162 1 NC_008369.1 isoprenoid biosynthesis protein with amidotransferase-like domain 905162 4307021 FTH_0907 Francisella tularensis subsp. holarctica OSU18 isoprenoid biosynthesis protein with amidotransferase-like domain YP_763454.1 904503 D 393011 CDS YP_763455.1 115314732 4307022 905178..905924 1 NC_008369.1 hypothetical protein 905924 4307022 FTH_0908 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763455.1 905178 D 393011 CDS YP_763456.1 115314733 4307023 906021..906536 1 NC_008369.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 906536 ruvC 4307023 ruvC Francisella tularensis subsp. holarctica OSU18 Holliday junction resolvase YP_763456.1 906021 D 393011 CDS YP_763457.1 115314734 4307024 906609..907808 1 NC_008369.1 major facilitator transporter 907808 4307024 FTH_0910 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_763457.1 906609 D 393011 CDS YP_763458.1 115314735 4307025 907821..908471 1 NC_008369.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 908471 ruvA 4307025 ruvA Francisella tularensis subsp. holarctica OSU18 Holliday junction DNA helicase RuvA YP_763458.1 907821 D 393011 CDS YP_763459.1 115314736 4307026 908497..909912 1 NC_008369.1 DNA recombination protein RmuC 909912 rmuC 4307026 rmuC Francisella tularensis subsp. holarctica OSU18 DNA recombination protein RmuC YP_763459.1 908497 D 393011 CDS YP_763460.1 115314737 4307027 910091..910540 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 910540 4307027 FTH_0913 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763460.1 910091 D 393011 CDS YP_763461.1 115314738 4307028 complement(910562..910858) 1 NC_008369.1 transcription regulator ArsR 910858 4307028 FTH_0914 Francisella tularensis subsp. holarctica OSU18 transcription regulator ArsR YP_763461.1 910562 R 393011 CDS YP_763462.1 115314739 4307030 911514..912326 1 NC_008369.1 hypothetical protein 912326 4307030 FTH_0916 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763462.1 911514 D 393011 CDS YP_763463.1 115314740 4307031 complement(912313..913449) 1 NC_008369.1 catalyzes the formation of histamine from L-histidine; histidine decarboxylase 913449 hdc 4307031 hdc Francisella tularensis subsp. holarctica OSU18 histidine decarboxylase YP_763463.1 912313 R 393011 CDS YP_763464.1 115314741 4307032 complement(913464..914162) 1 NC_008369.1 class II aldolase/adducin 914162 4307032 FTH_0918 Francisella tularensis subsp. holarctica OSU18 class II aldolase/adducin YP_763464.1 913464 R 393011 CDS YP_763465.1 115314742 4307033 complement(914253..914834) 1 NC_008369.1 DNA methylpurine-DNA glycosylase 914834 4307033 FTH_0919 Francisella tularensis subsp. holarctica OSU18 DNA methylpurine-DNA glycosylase YP_763465.1 914253 R 393011 CDS YP_763466.1 115314743 4307034 914962..915465 1 NC_008369.1 amidohydrolase 915465 4307034 FTH_0920 Francisella tularensis subsp. holarctica OSU18 amidohydrolase YP_763466.1 914962 D 393011 CDS YP_763467.1 115314744 4307035 915465..916097 1 NC_008369.1 NMC family nicotinamide mononucleotide uptake permease PnuC 916097 4307035 FTH_0921 Francisella tularensis subsp. holarctica OSU18 NMC family nicotinamide mononucleotide uptake permease PnuC YP_763467.1 915465 D 393011 CDS YP_763468.1 115314745 4307036 916216..917391 1 NC_008369.1 CPA2 family monovalent cation:proton (H+) antiporter-2 917391 4307036 FTH_0922 Francisella tularensis subsp. holarctica OSU18 CPA2 family monovalent cation:proton (H+) antiporter-2 YP_763468.1 916216 D 393011 CDS YP_763469.1 115314746 4307037 complement(917724..918188) 1 NC_008369.1 hypothetical protein 918188 4307037 FTH_0923 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763469.1 917724 R 393011 CDS YP_763470.1 115314747 4307041 922280..923248 1 NC_008369.1 phosphoribosyl diphosphate synthetase; ribose-phosphate diphosphokinase 923248 prsA 4307041 prsA Francisella tularensis subsp. holarctica OSU18 ribose-phosphate diphosphokinase YP_763470.1 922280 D 393011 CDS YP_763471.1 115314748 4307042 923348..923638 1 NC_008369.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 923638 rplY 4307042 rplY Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L25 YP_763471.1 923348 D 393011 CDS YP_763472.1 115314749 4307043 923734..924993 1 NC_008369.1 HCC family HlyC/CorC transporter 924993 4307043 FTH_0929 Francisella tularensis subsp. holarctica OSU18 HCC family HlyC/CorC transporter YP_763472.1 923734 D 393011 CDS YP_763473.1 115314750 4307046 complement(926592..926867) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 926867 4307046 FTH_0932 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763473.1 926592 R 393011 CDS YP_763474.1 115314751 4307047 complement(926882..927973) 1 NC_008369.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 927973 4307047 FTH_0933 Francisella tularensis subsp. holarctica OSU18 GTP-dependent nucleic acid-binding protein EngD YP_763474.1 926882 R 393011 CDS YP_763475.1 115314752 4307048 complement(927992..928567) 1 NC_008369.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 928567 pth 4307048 pth Francisella tularensis subsp. holarctica OSU18 peptidyl-tRNA hydrolase YP_763475.1 927992 R 393011 CDS YP_763476.1 115314753 4307049 complement(928560..929444) 1 NC_008369.1 cephalosporinase; beta-lactamase 929444 penP 4307049 penP Francisella tularensis subsp. holarctica OSU18 beta-lactamase YP_763476.1 928560 R 393011 CDS YP_763477.1 115314754 4307050 complement(929453..930298) 1 NC_008369.1 hypothetical protein 930298 4307050 FTH_0936 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763477.1 929453 R 393011 CDS YP_763478.1 115314755 4307051 complement(930338..931156) 1 NC_008369.1 prepilin peptidase 931156 pulO 4307051 pulO Francisella tularensis subsp. holarctica OSU18 prepilin peptidase YP_763478.1 930338 R 393011 CDS YP_763479.1 115314756 4307052 complement(931160..932575) 1 NC_008369.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 932575 4307052 FTH_0938 Francisella tularensis subsp. holarctica OSU18 soluble pyridine nucleotide transhydrogenase YP_763479.1 931160 R 393011 CDS YP_763480.1 115314757 4307054 complement(933891..935348) 1 NC_008369.1 POT family proton (H+)-dependent oligopeptide transporter 935348 4307054 FTH_0940 Francisella tularensis subsp. holarctica OSU18 POT family proton (H+)-dependent oligopeptide transporter YP_763480.1 933891 R 393011 CDS YP_763481.1 115314758 4307055 complement(935444..936811) 1 NC_008369.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 936811 hslU 4307055 hslU Francisella tularensis subsp. holarctica OSU18 ATP-dependent protease ATP-binding subunit HslU YP_763481.1 935444 R 393011 CDS YP_763482.1 115314759 4307056 complement(936819..937391) 1 NC_008369.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 937391 hslV 4307056 hslV Francisella tularensis subsp. holarctica OSU18 ATP-dependent protease peptidase subunit YP_763482.1 936819 R 393011 CDS YP_763483.1 115314760 4307057 937562..938311 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 938311 4307057 FTH_0943 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763483.1 937562 D 393011 CDS YP_763484.1 115314761 4307058 complement(938314..939216) 1 NC_008369.1 lipoate--protein ligase A 939216 lplA 4307058 lplA Francisella tularensis subsp. holarctica OSU18 lipoate--protein ligase A YP_763484.1 938314 R 393011 CDS YP_763485.1 115314762 4307059 939356..940546 1 NC_008369.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 940546 tyrS 4307059 tyrS Francisella tularensis subsp. holarctica OSU18 tyrosyl-tRNA synthetase YP_763485.1 939356 D 393011 CDS YP_763486.1 115314763 4307060 940543..940722 1 NC_008369.1 hypothetical protein 940722 4307060 FTH_0946 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763486.1 940543 D 393011 CDS YP_763487.1 115314764 4307061 complement(join(940950..941501,941501..941830)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 941830 isftu1 4307061 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763487.1 940950 R 393011 CDS YP_763488.1 115314765 4307062 942179..943066 1 NC_008369.1 cytochrome b2; L-lactate dehydrogenase (cytochrome) 943066 lldA 4307062 lldA Francisella tularensis subsp. holarctica OSU18 L-lactate dehydrogenase (cytochrome) YP_763488.1 942179 D 393011 CDS YP_763489.1 115314766 4307063 943089..943265 1 NC_008369.1 pyruvate decarboxylase 943265 4307063 FTH_0949 Francisella tularensis subsp. holarctica OSU18 pyruvate decarboxylase YP_763489.1 943089 D 393011 CDS YP_763490.1 115314767 4307064 943506..944885 1 NC_008369.1 FAD/FMN-dehydrogenase 944885 4307064 FTH_0950 Francisella tularensis subsp. holarctica OSU18 FAD/FMN-dehydrogenase YP_763490.1 943506 D 393011 CDS YP_763491.1 115314768 4307066 946210..947367 1 NC_008369.1 iron (Fe2+)-dependent alcohol dehydrogenase 947367 4307066 FTH_0952 Francisella tularensis subsp. holarctica OSU18 iron (Fe2+)-dependent alcohol dehydrogenase YP_763491.1 946210 D 393011 CDS YP_763492.1 115314769 4307067 947590..948435 1 NC_008369.1 50S ribosomal protein L11 methyltransferase 948435 prmA 4307067 prmA Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L11 methyltransferase YP_763492.1 947590 D 393011 CDS YP_763493.1 115314770 4307068 948425..949408 1 NC_008369.1 tRNA-dihydrouridine synthase 949408 4307068 FTH_0954 Francisella tularensis subsp. holarctica OSU18 tRNA-dihydrouridine synthase YP_763493.1 948425 D 393011 CDS YP_763494.1 115314771 4307069 949638..951965 1 NC_008369.1 type I restriction enzyme; type I site-specific deoxyribonuclease 951965 4307069 FTH_0955 Francisella tularensis subsp. holarctica OSU18 type I site-specific deoxyribonuclease YP_763494.1 949638 D 393011 CDS YP_763495.1 115314772 4307070 952207..952593 1 NC_008369.1 hypothetical protein 952593 4307070 FTH_0956 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763495.1 952207 D 393011 CDS YP_763496.1 115314773 4307072 953302..954417 1 NC_008369.1 hypothetical protein 954417 4307072 FTH_0958 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763496.1 953302 D 393011 CDS YP_763497.1 115314774 4307073 954575..954712 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 954712 4307073 FTH_0959 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763497.1 954575 D 393011 CDS YP_763498.1 115314775 4307074 complement(954732..955781) 1 NC_008369.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 955781 dinB 4307074 dinB Francisella tularensis subsp. holarctica OSU18 DNA polymerase IV YP_763498.1 954732 R 393011 CDS YP_763499.1 115314776 4307075 complement(955788..956390) 1 NC_008369.1 DJ-1/PfpI family protein 956390 4307075 FTH_0961 Francisella tularensis subsp. holarctica OSU18 DJ-1/PfpI family protein YP_763499.1 955788 R 393011 CDS YP_763500.1 115314777 4307076 956501..957547 1 NC_008369.1 ABC transporter ATP-binding protein 957547 4307076 FTH_0962 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_763500.1 956501 D 393011 CDS YP_763501.1 115314778 4307077 complement(957544..958776) 1 NC_008369.1 ribonucleotide reductase; bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta 958776 4307077 FTH_0963 Francisella tularensis subsp. holarctica OSU18 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta YP_763501.1 957544 R 393011 CDS YP_763502.1 115314779 4307078 complement(958783..959043) 1 NC_008369.1 glutaredoxin 959043 grxA 4307078 grxA Francisella tularensis subsp. holarctica OSU18 glutaredoxin YP_763502.1 958783 R 393011 CDS YP_763503.1 115314780 4307079 complement(959047..960819) 1 NC_008369.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 960819 nrdA 4307079 nrdA Francisella tularensis subsp. holarctica OSU18 ribonucleotide-diphosphate reductase subunit alpha YP_763503.1 959047 R 393011 CDS YP_763504.1 115314781 4307080 complement(961023..962033) 1 NC_008369.1 Catalyzes the reversible oxidation of malate to oxaloacetate; malate dehydrogenase 962033 mdh 4307080 mdh Francisella tularensis subsp. holarctica OSU18 malate dehydrogenase YP_763504.1 961023 R 393011 CDS YP_763505.1 115314782 4307081 962142..962657 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 962657 4307081 FTH_0967 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763505.1 962142 D 393011 CDS YP_763506.1 115314783 4307082 962673..963308 1 NC_008369.1 ubiquinone biosynthesis protein 963308 4307082 FTH_0968 Francisella tularensis subsp. holarctica OSU18 ubiquinone biosynthesis protein YP_763506.1 962673 D 393011 CDS YP_763507.1 115314784 4307083 complement(963317..963886) 1 NC_008369.1 hypothetical protein 963886 4307083 FTH_0969 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763507.1 963317 R 393011 CDS YP_763508.1 115314785 4307085 join(964509..964838,964838..965389) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 965389 isftu1 4307085 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763508.1 964509 D 393011 CDS YP_763509.1 115314786 4307086 complement(965674..967164) 1 NC_008369.1 hypothetical protein 967164 4307086 FTH_0972 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763509.1 965674 R 393011 CDS YP_763510.1 115314787 4307087 complement(967219..967818) 1 NC_008369.1 phosphatase 967818 4307087 FTH_0973 Francisella tularensis subsp. holarctica OSU18 phosphatase YP_763510.1 967219 R 393011 CDS YP_763511.1 115314788 4307088 967896..968495 1 NC_008369.1 peroxiredoxin 968495 ahpC 4307088 ahpC Francisella tularensis subsp. holarctica OSU18 peroxiredoxin YP_763511.1 967896 D 393011 CDS YP_763512.1 115314789 4307090 970042..970308 1 NC_008369.1 phosphonoacetate hydrolase 970308 phnA 4307090 phnA Francisella tularensis subsp. holarctica OSU18 phosphonoacetate hydrolase YP_763512.1 970042 D 393011 CDS YP_763513.1 115314790 4307091 970381..970596 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 970596 4307091 FTH_0977 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763513.1 970381 D 393011 CDS YP_763514.1 115314791 4307092 970600..971211 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 971211 4307092 FTH_0978 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763514.1 970600 D 393011 CDS YP_763515.1 115314792 4307094 972129..972845 1 NC_008369.1 DNA nucleotidyltransferase (DNA-directed); DNA-directed DNA polymerase 972845 dnaQ 4307094 dnaQ Francisella tularensis subsp. holarctica OSU18 DNA-directed DNA polymerase YP_763515.1 972129 D 393011 CDS YP_763516.1 115314793 4307095 972839..973312 1 NC_008369.1 D-alanyl-D-alanine carboxypeptidase 973312 vanY 4307095 vanY Francisella tularensis subsp. holarctica OSU18 D-alanyl-D-alanine carboxypeptidase YP_763516.1 972839 D 393011 CDS YP_763517.1 115314794 4307096 973272..974708 1 NC_008369.1 hypothetical protein 974708 4307096 FTH_0982 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763517.1 973272 D 393011 CDS YP_763518.1 115314795 4307097 974996..975169 1 NC_008369.1 hypothetical protein 975169 4307097 FTH_0983 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763518.1 974996 D 393011 CDS YP_763519.1 115314796 4307101 977182..977454 1 NC_008369.1 hypothetical protein 977454 4307101 FTH_0987 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763519.1 977182 D 393011 CDS YP_763520.1 115314797 4307102 977468..978199 1 NC_008369.1 hypothetical protein 978199 4307102 FTH_0988 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763520.1 977468 D 393011 CDS YP_763521.1 115314798 4307103 complement(978202..979071) 1 NC_008369.1 oxidative stress transcriptional regulator 979071 4307103 FTH_0989 Francisella tularensis subsp. holarctica OSU18 oxidative stress transcriptional regulator YP_763521.1 978202 R 393011 CDS YP_763522.1 115314799 4307104 979169..979693 1 NC_008369.1 AhpC/TSA family protein 979693 4307104 FTH_0990 Francisella tularensis subsp. holarctica OSU18 AhpC/TSA family protein YP_763522.1 979169 D 393011 CDS YP_763523.1 115314800 4307105 979696..980307 1 NC_008369.1 short chain dehydrogenase 980307 4307105 FTH_0991 Francisella tularensis subsp. holarctica OSU18 short chain dehydrogenase YP_763523.1 979696 D 393011 CDS YP_763524.1 115314801 4307106 complement(980324..980989) 1 NC_008369.1 CMP kinase; cytidylate kinase 980989 cmk 4307106 cmk Francisella tularensis subsp. holarctica OSU18 cytidylate kinase YP_763524.1 980324 R 393011 CDS YP_763525.1 115314802 4307107 complement(980976..982028) 1 NC_008369.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 982028 serC 4307107 serC Francisella tularensis subsp. holarctica OSU18 phosphoserine aminotransferase YP_763525.1 980976 R 393011 CDS YP_763526.1 115314803 4307108 complement(982103..982357) 1 NC_008369.1 hypothetical protein 982357 4307108 FTH_0994 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763526.1 982103 R 393011 CDS YP_763527.1 115314804 4307109 join(982348..982677,982677..983228) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 983228 isftu1 4307109 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763527.1 982348 D 393011 CDS YP_763528.1 115314805 4307110 complement(983206..984261) 1 NC_008369.1 hypothetical protein 984261 4307110 FTH_0996 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763528.1 983206 R 393011 CDS YP_763529.1 115314806 4307111 complement(984286..985212) 1 NC_008369.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 985212 hemF 4307111 hemF Francisella tularensis subsp. holarctica OSU18 coproporphyrinogen III oxidase YP_763529.1 984286 R 393011 CDS YP_763530.1 115314807 4307113 986279..986632 1 NC_008369.1 hypothetical protein 986632 4307113 FTH_0999 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763530.1 986279 D 393011 CDS YP_763531.1 115314808 4307114 986720..987082 1 NC_008369.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 987082 rpsF 4307114 rpsF Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S6 YP_763531.1 986720 D 393011 CDS YP_763532.1 115314809 4307115 987098..987316 1 NC_008369.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 987316 rpsR 4307115 rpsR Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S18 YP_763532.1 987098 D 393011 CDS YP_763533.1 115314810 4307116 987326..987790 1 NC_008369.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 987790 rplI 4307116 rplI Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L9 YP_763533.1 987326 D 393011 CDS YP_763534.1 115314811 4307117 987878..989275 1 NC_008369.1 replicative DNA helicase 989275 dnaB 4307117 dnaB Francisella tularensis subsp. holarctica OSU18 replicative DNA helicase YP_763534.1 987878 D 393011 CDS YP_763535.1 115314812 4307118 989306..990418 1 NC_008369.1 Fe-S-cluster oxidoreductase 990418 4307118 FTH_1004 Francisella tularensis subsp. holarctica OSU18 Fe-S-cluster oxidoreductase YP_763535.1 989306 D 393011 CDS YP_763536.1 115314813 4307119 990408..991313 1 NC_008369.1 type IV pilus assembly protein 991313 pilF 4307119 pilF Francisella tularensis subsp. holarctica OSU18 type IV pilus assembly protein YP_763536.1 990408 D 393011 CDS YP_763537.1 115314814 4307120 991306..992121 1 NC_008369.1 pseudouridine synthase; pseudouridylate synthase 992121 rluB 4307120 rluB Francisella tularensis subsp. holarctica OSU18 pseudouridylate synthase YP_763537.1 991306 D 393011 CDS YP_763538.1 115314815 4307121 992121..992546 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 992546 4307121 FTH_1007 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763538.1 992121 D 393011 CDS YP_763539.1 115314816 4307122 992524..992964 1 NC_008369.1 acetyl-CoA:dihydrolipoamide S-acetyltransferase; dihydrolipoyllysine-residue acetyltransferase 992964 4307122 FTH_1008 Francisella tularensis subsp. holarctica OSU18 dihydrolipoyllysine-residue acetyltransferase YP_763539.1 992524 D 393011 CDS YP_763540.1 115314817 4307124 994168..994311 1 NC_008369.1 hypothetical protein 994311 4307124 FTH_1010 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763540.1 994168 D 393011 CDS YP_763541.1 115314818 4307125 994341..994478 1 NC_008369.1 hypothetical protein 994478 4307125 FTH_1011 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763541.1 994341 D 393011 CDS YP_763542.1 115314819 4307126 994739..994945 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 994945 4307126 FTH_1012 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763542.1 994739 D 393011 CDS YP_763543.1 115314820 4307127 995393..995545 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 995545 4307127 FTH_1013 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763543.1 995393 D 393011 CDS YP_763544.1 115314821 4307130 998453..999019 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 999019 4307130 FTH_1016 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763544.1 998453 D 393011 CDS YP_763545.1 115314822 4307131 999071..999436 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 999436 4307131 FTH_1017 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763545.1 999071 D 393011 CDS YP_763546.1 115314823 4307132 1000103..1000726 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1000726 4307132 FTH_1018 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763546.1 1000103 D 393011 CDS YP_763547.1 115314824 4307133 1000807..1001238 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1001238 4307133 FTH_1019 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763547.1 1000807 D 393011 CDS YP_763548.1 115314825 4307134 1001328..1002305 1 NC_008369.1 octaprenyl-diphosphate synthase 1002305 ispB 4307134 ispB Francisella tularensis subsp. holarctica OSU18 octaprenyl-diphosphate synthase YP_763548.1 1001328 D 393011 CDS YP_763549.1 115314826 4307135 complement(1002323..1003135) 1 NC_008369.1 cyclophilin; peptidyl-prolyl isomerase 1003135 4307135 FTH_1021 Francisella tularensis subsp. holarctica OSU18 peptidyl-prolyl isomerase YP_763549.1 1002323 R 393011 CDS YP_763550.1 115314827 4307136 complement(1003149..1003952) 1 NC_008369.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1003952 4307136 FTH_1022 Francisella tularensis subsp. holarctica OSU18 C32 tRNA thiolase YP_763550.1 1003149 R 393011 CDS YP_763551.1 115314828 4307137 complement(1003945..1004361) 1 NC_008369.1 hypothetical protein 1004361 4307137 FTH_1023 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763551.1 1003945 R 393011 CDS YP_763552.1 115314829 4307138 complement(1004377..1004988) 1 NC_008369.1 hypothetical protein 1004988 4307138 FTH_1024 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763552.1 1004377 R 393011 CDS YP_763553.1 115314830 4307139 complement(1004989..1006392) 1 NC_008369.1 D-alanyl-D-alanine carboxypeptidase; serine-type D-Ala-D-Ala carboxypeptidase 1006392 dacB 4307139 dacB Francisella tularensis subsp. holarctica OSU18 serine-type D-Ala-D-Ala carboxypeptidase YP_763553.1 1004989 R 393011 CDS YP_763554.1 115314831 4306670 1006648..1006845 1 NC_008369.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1006845 rpsU 4306670 rpsU Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S21 YP_763554.1 1006648 D 393011 CDS YP_763555.1 115314832 4306671 1006906..1007352 1 NC_008369.1 GatB domain-containing protein 1007352 4306671 FTH_1027 Francisella tularensis subsp. holarctica OSU18 GatB domain-containing protein YP_763555.1 1006906 D 393011 CDS YP_763556.1 115314833 4306672 1007373..1009190 1 NC_008369.1 DNA primase 1009190 dnaG 4306672 dnaG Francisella tularensis subsp. holarctica OSU18 DNA primase YP_763556.1 1007373 D 393011 CDS YP_763557.1 115314834 4306673 1009215..1010948 1 NC_008369.1 RNA polymerase sigma-70 factor 1010948 rpoD 4306673 rpoD Francisella tularensis subsp. holarctica OSU18 RNA polymerase sigma-70 factor YP_763557.1 1009215 D 393011 CDS YP_763558.1 115314835 4306674 1011055..1012305 1 NC_008369.1 beta-NADH dehydrogenase dinucleotide; NADH dehydrogenase 1012305 ndh 4306674 ndh Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase YP_763558.1 1011055 D 393011 CDS YP_763559.1 115314836 4306677 1016050..1016145 1 NC_008369.1 hypothetical protein 1016145 4306677 FTH_1033 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763559.1 1016050 D 393011 CDS YP_763560.1 115314837 4306678 complement(1016363..1016983) 1 NC_008369.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 1016983 lipB 4306678 lipB Francisella tularensis subsp. holarctica OSU18 lipoate-protein ligase B YP_763560.1 1016363 R 393011 CDS YP_763561.1 115314838 4306679 complement(1016993..1017277) 1 NC_008369.1 hypothetical protein 1017277 4306679 FTH_1035 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763561.1 1016993 R 393011 CDS YP_763562.1 115314839 4306680 complement(1017310..1018644) 1 NC_008369.1 D-alanyl-D-alanine carboxypeptidase; serine-type D-Ala-D-Ala carboxypeptidase 1018644 4306680 FTH_1036 Francisella tularensis subsp. holarctica OSU18 serine-type D-Ala-D-Ala carboxypeptidase YP_763562.1 1017310 R 393011 CDS YP_763563.1 115314840 4306681 1018801..1019322 1 NC_008369.1 diphosphate phosphohydrolase; inorganic pyrophosphatase 1019322 ppa 4306681 ppa Francisella tularensis subsp. holarctica OSU18 inorganic pyrophosphatase YP_763563.1 1018801 D 393011 CDS YP_763564.1 115314841 4306682 1019413..1019961 1 NC_008369.1 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 1019961 kdsC 4306682 kdsC Francisella tularensis subsp. holarctica OSU18 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_763564.1 1019413 D 393011 CDS YP_763565.1 115314842 4306683 1019969..1020595 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1020595 4306683 FTH_1039 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763565.1 1019969 D 393011 CDS YP_763566.1 115314843 4306684 1020582..1021415 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1021415 4306684 FTH_1040 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763566.1 1020582 D 393011 CDS YP_763567.1 115314844 4306685 1021489..1022220 1 NC_008369.1 ABC transporter ATP-binding protein 1022220 4306685 FTH_1041 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_763567.1 1021489 D 393011 CDS YP_763568.1 115314845 4306686 1022269..1022862 1 NC_008369.1 fumarylacetoacetate hydrolase family protein 1022862 4306686 FTH_1042 Francisella tularensis subsp. holarctica OSU18 fumarylacetoacetate hydrolase family protein YP_763568.1 1022269 D 393011 CDS YP_763569.1 115314846 4306687 1022875..1024707 1 NC_008369.1 bifunctional phosphorylase/lipase 1024707 4306687 FTH_1043 Francisella tularensis subsp. holarctica OSU18 bifunctional phosphorylase/lipase YP_763569.1 1022875 D 393011 CDS YP_763570.1 115314847 4306688 1024710..1025486 1 NC_008369.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1025486 truA 4306688 truA Francisella tularensis subsp. holarctica OSU18 tRNA pseudouridine synthase A YP_763570.1 1024710 D 393011 CDS YP_763571.1 115314848 4306690 1027173..1028723 1 NC_008369.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1028723 guaA 4306690 guaA Francisella tularensis subsp. holarctica OSU18 GMP synthase YP_763571.1 1027173 D 393011 CDS YP_763572.1 115314849 4306691 1028805..1030652 1 NC_008369.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1030652 dxs 4306691 dxs Francisella tularensis subsp. holarctica OSU18 1-deoxy-D-xylulose-5-phosphate synthase YP_763572.1 1028805 D 393011 CDS YP_763573.1 115314850 4306692 1030668..1031003 1 NC_008369.1 hypothetical protein 1031003 4306692 FTH_1048 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763573.1 1030668 D 393011 CDS YP_763574.1 115314851 4306693 1031025..1031654 1 NC_008369.1 lipase 1031654 4306693 FTH_1049 Francisella tularensis subsp. holarctica OSU18 lipase YP_763574.1 1031025 D 393011 CDS YP_763575.1 115314852 4306694 complement(1031664..1032254) 1 NC_008369.1 hypothetical protein 1032254 4306694 FTH_1050 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763575.1 1031664 R 393011 CDS YP_763576.1 115314853 4306695 1032372..1033097 1 NC_008369.1 short chain dehydrogenase family protein 1033097 4306695 FTH_1051 Francisella tularensis subsp. holarctica OSU18 short chain dehydrogenase family protein YP_763576.1 1032372 D 393011 CDS YP_763577.1 115314854 4306696 1033161..1034207 1 NC_008369.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1034207 ruvB 4306696 ruvB Francisella tularensis subsp. holarctica OSU18 Holliday junction DNA helicase RuvB YP_763577.1 1033161 D 393011 CDS YP_763578.1 115314855 4306698 complement(1035190..1035378) 1 NC_008369.1 hypothetical protein 1035378 4306698 FTH_1054 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763578.1 1035190 R 393011 CDS YP_763579.1 115314856 4306699 complement(1035490..1035693) 1 NC_008369.1 transcriptional regulator 1035693 4306699 FTH_1055 Francisella tularensis subsp. holarctica OSU18 transcriptional regulator YP_763579.1 1035490 R 393011 CDS YP_763580.1 115314857 4306701 1036371..1036499 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1036499 4306701 FTH_1057 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763580.1 1036371 D 393011 CDS YP_763581.1 115314858 4306704 1038548..1038733 1 NC_008369.1 hypothetical protein 1038733 4306704 FTH_1060 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763581.1 1038548 D 393011 CDS YP_763582.1 115314859 4306705 1038756..1038887 1 NC_008369.1 hypothetical protein 1038887 4306705 FTH_1061 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763582.1 1038756 D 393011 CDS YP_763583.1 115314860 4306708 complement(1040380..1040733) 1 NC_008369.1 hypothetical protein 1040733 4306708 FTH_1064 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763583.1 1040380 R 393011 CDS YP_763584.1 115314861 4306710 complement(1041960..1042712) 1 NC_008369.1 rRNA methyltransferase 1042712 spoU 4306710 spoU Francisella tularensis subsp. holarctica OSU18 rRNA methyltransferase YP_763584.1 1041960 R 393011 CDS YP_763585.1 115314862 4306712 complement(1044801..1045277) 1 NC_008369.1 tryptophan-rich sensory protein 1045277 tspO 4306712 tspO Francisella tularensis subsp. holarctica OSU18 tryptophan-rich sensory protein YP_763585.1 1044801 R 393011 CDS YP_763586.1 115314863 4306713 1045406..1046260 1 NC_008369.1 this fusion consists of methionine sulfoxide B reductase at the N-terminus and A at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion protein of these enzymes with thioredoxin provides protection against oxidative stress in Neisseria gonorrhoeae; bifunctional methionine sulfoxide reductase B/A protein 1046260 msrA1 4306713 msrA1 Francisella tularensis subsp. holarctica OSU18 bifunctional methionine sulfoxide reductase B/A protein YP_763586.1 1045406 D 393011 CDS YP_763587.1 115314864 4306715 complement(1047720..1048841) 1 NC_008369.1 thioredoxin family protein 1048841 4306715 FTH_1071 Francisella tularensis subsp. holarctica OSU18 thioredoxin family protein YP_763587.1 1047720 R 393011 CDS YP_763588.1 115314865 4306718 complement(1050329..1050736) 1 NC_008369.1 hypothetical protein 1050736 4306718 FTH_1074 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763588.1 1050329 R 393011 CDS YP_763589.1 115314866 4306719 1050809..1051102 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1051102 4306719 FTH_1075 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763589.1 1050809 D 393011 CDS YP_763590.1 115314867 4306720 1051129..1051461 1 NC_008369.1 hypothetical protein 1051461 4306720 FTH_1076 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763590.1 1051129 D 393011 CDS YP_763591.1 115314868 4306722 complement(1053011..1053457) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1053457 4306722 FTH_1078 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763591.1 1053011 R 393011 CDS YP_763592.1 115314869 4306723 1053613..1056210 1 NC_008369.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1056210 alaS 4306723 alaS Francisella tularensis subsp. holarctica OSU18 alanyl-tRNA synthetase YP_763592.1 1053613 D 393011 CDS YP_763593.1 115314870 4306724 1056218..1057600 1 NC_008369.1 outer membrane protein TolC 1057600 4306724 FTH_1080 Francisella tularensis subsp. holarctica OSU18 outer membrane protein TolC YP_763593.1 1056218 D 393011 CDS YP_763594.1 115314871 4306725 1057603..1058982 1 NC_008369.1 cytosol aminopeptidase; leucyl aminopeptidase 1058982 4306725 FTH_1081 Francisella tularensis subsp. holarctica OSU18 leucyl aminopeptidase YP_763594.1 1057603 D 393011 CDS YP_763595.1 115314872 4306726 1059062..1060081 1 NC_008369.1 dihydroxyacetone transferase; transaldolase B 1060081 talA 4306726 talA Francisella tularensis subsp. holarctica OSU18 transaldolase B YP_763595.1 1059062 D 393011 CDS YP_763596.1 115314873 4306730 complement(1062136..1062771) 1 NC_008369.1 NMC family nicotinamide mononucleotide uptake permease PnuC 1062771 4306730 FTH_1086 Francisella tularensis subsp. holarctica OSU18 NMC family nicotinamide mononucleotide uptake permease PnuC YP_763596.1 1062136 R 393011 CDS YP_763597.1 115314874 4306731 complement(1062811..1063332) 1 NC_008369.1 nicotinamidase 1063332 4306731 FTH_1087 Francisella tularensis subsp. holarctica OSU18 nicotinamidase YP_763597.1 1062811 R 393011 CDS YP_763598.1 115314875 4306732 1063940..1064686 1 NC_008369.1 hypothetical protein 1064686 4306732 FTH_1088 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763598.1 1063940 D 393011 CDS YP_763599.1 115314876 4306733 1064680..1066695 1 NC_008369.1 ATP-dependent DNA helicase 1066695 uvrD1 4306733 uvrD1 Francisella tularensis subsp. holarctica OSU18 ATP-dependent DNA helicase YP_763599.1 1064680 D 393011 CDS YP_763600.1 115314877 4306734 1066751..1067581 1 NC_008369.1 hypothetical protein 1067581 4306734 FTH_1090 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763600.1 1066751 D 393011 CDS YP_763601.1 115314878 4306735 complement(1067712..1068698) 1 NC_008369.1 rhodanese sulfurtransferase 1068698 4306735 FTH_1091 Francisella tularensis subsp. holarctica OSU18 rhodanese sulfurtransferase YP_763601.1 1067712 R 393011 CDS YP_763602.1 115314879 4306736 1068892..1069752 1 NC_008369.1 Required for efficient pilin antigenic variation; recombination associated protein 1069752 rdgC 4306736 rdgC Francisella tularensis subsp. holarctica OSU18 recombination associated protein YP_763602.1 1068892 D 393011 CDS YP_763603.1 115314880 4306737 1069757..1070014 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1070014 4306737 FTH_1093 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763603.1 1069757 D 393011 CDS YP_763604.1 115314881 4306738 complement(1070030..1070452) 1 NC_008369.1 hypothetical protein 1070452 4306738 FTH_1094 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763604.1 1070030 R 393011 CDS YP_763605.1 115314882 4306739 1070678..1071481 1 NC_008369.1 hypothetical protein 1071481 4306739 FTH_1095 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763605.1 1070678 D 393011 CDS YP_763606.1 115314883 4306741 1072648..1073463 1 NC_008369.1 hypothetical protein 1073463 4306741 FTH_1097 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763606.1 1072648 D 393011 CDS YP_763607.1 115314884 4306742 1073444..1073830 1 NC_008369.1 hypothetical protein 1073830 4306742 FTH_1098 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763607.1 1073444 D 393011 CDS YP_763608.1 115314885 4306743 complement(1073954..1075228) 1 NC_008369.1 transcriptional regulator 1075228 hipA 4306743 hipA Francisella tularensis subsp. holarctica OSU18 transcriptional regulator YP_763608.1 1073954 R 393011 CDS YP_763609.1 115314886 4306744 complement(1075213..1075440) 1 NC_008369.1 transcriptional regulator 1075440 4306744 FTH_1100 Francisella tularensis subsp. holarctica OSU18 transcriptional regulator YP_763609.1 1075213 R 393011 CDS YP_763610.1 115314887 4306745 1075705..1075914 1 NC_008369.1 hypothetical protein 1075914 4306745 FTH_1101 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763610.1 1075705 D 393011 CDS YP_763611.1 115314888 4306746 1076138..1076227 1 NC_008369.1 hypothetical protein 1076227 4306746 FTH_1102 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763611.1 1076138 D 393011 CDS YP_763612.1 115314889 4306747 complement(join(1076228..1076779,1076779..1077108)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1077108 isftu1 4306747 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763612.1 1076228 R 393011 CDS YP_763613.1 115314890 4306748 1077099..1077368 1 NC_008369.1 hypothetical protein 1077368 4306748 FTH_1104 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763613.1 1077099 D 393011 CDS YP_763614.1 115314891 4306749 1077461..1077952 1 NC_008369.1 acetyltransferase 1077952 4306749 FTH_1105 Francisella tularensis subsp. holarctica OSU18 acetyltransferase YP_763614.1 1077461 D 393011 CDS YP_763615.1 115314892 4306751 complement(1079210..1079998) 1 NC_008369.1 inositol 1-phosphatase; inositol-phosphate phosphatase 1079998 suhB 4306751 suhB Francisella tularensis subsp. holarctica OSU18 inositol-phosphate phosphatase YP_763615.1 1079210 R 393011 CDS YP_763616.1 115314893 4306752 complement(1080085..1081137) 1 NC_008369.1 hypothetical protein 1081137 4306752 FTH_1108 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763616.1 1080085 R 393011 CDS YP_763617.1 115314894 4306753 complement(1081227..1082435) 1 NC_008369.1 hypothetical protein 1082435 4306753 FTH_1109 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763617.1 1081227 R 393011 CDS YP_763618.1 115314895 4306755 complement(1083233..1083547) 1 NC_008369.1 hypothetical protein 1083547 4306755 FTH_1111 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763618.1 1083233 R 393011 CDS YP_763619.1 115314896 4306756 complement(1083598..1084857) 1 NC_008369.1 beta-ketoacyl-ACP synthase; 3-oxoacyl-ACP synthase 1084857 fabF 4306756 fabF Francisella tularensis subsp. holarctica OSU18 3-oxoacyl-ACP synthase YP_763619.1 1083598 R 393011 CDS YP_763620.1 115314897 4306757 complement(1084937..1085275) 1 NC_008369.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1085275 acpP 4306757 acpP Francisella tularensis subsp. holarctica OSU18 acyl carrier protein YP_763620.1 1084937 R 393011 CDS YP_763621.1 115314898 4306758 complement(1085318..1086061) 1 NC_008369.1 3-oxoacyl-(acyl-carrier-protein) reductase 1086061 fabG 4306758 fabG Francisella tularensis subsp. holarctica OSU18 3-oxoacyl-(acyl-carrier-protein) reductase YP_763621.1 1085318 R 393011 CDS YP_763622.1 115314899 4306759 complement(1086075..1086995) 1 NC_008369.1 [acyl-carrier-protein] S-malonyltransferase 1086995 fabD 4306759 fabD Francisella tularensis subsp. holarctica OSU18 [acyl-carrier-protein] S-malonyltransferase YP_763622.1 1086075 R 393011 CDS YP_763623.1 115314900 4306760 complement(1087043..1088014) 1 NC_008369.1 beta-ketoacyl-ACP synthase; 3-oxoacyl-ACP synthase 1088014 fabH 4306760 fabH Francisella tularensis subsp. holarctica OSU18 3-oxoacyl-ACP synthase YP_763623.1 1087043 R 393011 CDS YP_763624.1 115314901 4306761 complement(1088111..1089157) 1 NC_008369.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 1089157 plsX 4306761 plsX Francisella tularensis subsp. holarctica OSU18 putative glycerol-3-phosphate acyltransferase PlsX YP_763624.1 1088111 R 393011 CDS YP_763625.1 115314902 4306762 complement(1089256..1089438) 1 NC_008369.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1089438 rpmF 4306762 rpmF Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L32 YP_763625.1 1089256 R 393011 CDS YP_763626.1 115314903 4306763 complement(1089482..1089985) 1 NC_008369.1 hypothetical protein 1089985 4306763 FTH_1119 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763626.1 1089482 R 393011 CDS YP_763627.1 115314904 4306764 1090124..1092115 1 NC_008369.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1092115 tktA 4306764 tktA Francisella tularensis subsp. holarctica OSU18 transketolase YP_763627.1 1090124 D 393011 CDS YP_763628.1 115314905 4306765 1092096..1093154 1 NC_008369.1 GAPDH; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 1093154 gapA 4306765 gapA Francisella tularensis subsp. holarctica OSU18 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) YP_763628.1 1092096 D 393011 CDS YP_763629.1 115314906 4306766 1093173..1094351 1 NC_008369.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1094351 pgk 4306766 pgk Francisella tularensis subsp. holarctica OSU18 phosphoglycerate kinase YP_763629.1 1093173 D 393011 CDS YP_763630.1 115314907 4306767 1094367..1095803 1 NC_008369.1 phosphoenol transphosphorylase; pyruvate kinase 1095803 pykA 4306767 pykA Francisella tularensis subsp. holarctica OSU18 pyruvate kinase YP_763630.1 1094367 D 393011 CDS YP_763631.1 115314908 4306768 1095822..1096886 1 NC_008369.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 1096886 fba 4306768 fba Francisella tularensis subsp. holarctica OSU18 fructose-1,6-bisphosphate aldolase YP_763631.1 1095822 D 393011 CDS YP_763632.1 115314909 4306773 1101418..1102008 1 NC_008369.1 IglA1; intracellular growth locus A protein 1102008 iglA1 4306773 iglA1 Francisella tularensis subsp. holarctica OSU18 intracellular growth locus A protein YP_763632.1 1101418 D 393011 CDS YP_763633.1 115314910 4306774 1101998..1103542 1 NC_008369.1 IglB1; intracellular growth locus B protein 1103542 iglB1 4306774 iglB1 Francisella tularensis subsp. holarctica OSU18 intracellular growth locus B protein YP_763633.1 1101998 D 393011 CDS YP_763634.1 115314911 4306775 1103559..1104188 1 NC_008369.1 IglC1; intracellular growth locus C protein 1104188 iglC1 4306775 iglC1 Francisella tularensis subsp. holarctica OSU18 intracellular growth locus C protein YP_763634.1 1103559 D 393011 CDS YP_763635.1 115314912 4306776 1104200..1105405 1 NC_008369.1 IglD1; intracellular growth locus D protein 1105405 iglD1 4306776 iglD1 Francisella tularensis subsp. holarctica OSU18 intracellular growth locus D protein YP_763635.1 1104200 D 393011 CDS YP_763636.1 115314913 4306777 complement(1105412..1105987) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1105987 4306777 FTH_1133 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763636.1 1105412 R 393011 CDS YP_763637.1 115314914 4306778 complement(1106005..1109991) 1 NC_008369.1 PdpC1; conserved in Francisella genomes; protein PdpC 1109991 pdpC1 4306778 pdpC1 Francisella tularensis subsp. holarctica OSU18 protein PdpC YP_763637.1 1106005 R 393011 CDS YP_763638.1 115314915 4306779 complement(1110031..1110804) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1110804 4306779 FTH_1135 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763638.1 1110031 R 393011 CDS YP_763639.1 115314916 4306780 complement(1110770..1111921) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1111921 4306780 FTH_1136 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763639.1 1110770 R 393011 CDS YP_763640.1 115314917 4306781 complement(1111943..1112566) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1112566 4306781 FTH_1137 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763640.1 1111943 R 393011 CDS YP_763641.1 115314918 4306782 complement(1112579..1114009) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1114009 4306782 FTH_1138 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763641.1 1112579 R 393011 CDS YP_763642.1 115314919 4306783 complement(1114022..1114543) 1 NC_008369.1 hypothetical protein 1114543 4306783 FTH_1139 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763642.1 1114022 R 393011 CDS YP_763643.1 115314920 4306784 complement(1114611..1116275) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1116275 4306784 FTH_1140 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763643.1 1114611 R 393011 CDS YP_763644.1 115314921 4306785 complement(1116280..1116774) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1116774 4306785 FTH_1141 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763644.1 1116280 R 393011 CDS YP_763645.1 115314922 4306786 complement(1116787..1117164) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1117164 4306786 FTH_1142 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763645.1 1116787 R 393011 CDS YP_763646.1 115314923 4306787 complement(1117154..1120435) 1 NC_008369.1 PdpB1; conserved in Francisella genomes; hypothetical protein 1120435 pdpB1 4306787 pdpB1 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763646.1 1117154 R 393011 CDS YP_763647.1 115314924 4306788 complement(1120440..1122902) 1 NC_008369.1 PdpA1; conserved in Francisella genomes; hypothetical protein 1122902 pdpA1 4306788 pdpA1 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763647.1 1120440 R 393011 CDS YP_763648.1 115314925 4306794 complement(1128471..1129040) 1 NC_008369.1 hypothetical protein 1129040 4306794 FTH_1146 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763648.1 1128471 R 393011 CDS YP_763649.1 115314926 4306795 complement(1129058..1129240) 1 NC_008369.1 hypothetical protein 1129240 4306795 FTH_1147 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763649.1 1129058 R 393011 CDS YP_763650.1 115314927 4306796 complement(1129302..1130225) 1 NC_008369.1 beta-thionase; cystathionine beta-synthase 1130225 cysK 4306796 cysK Francisella tularensis subsp. holarctica OSU18 cystathionine beta-synthase YP_763650.1 1129302 R 393011 CDS YP_763651.1 115314928 4306799 1132553..1132747 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1132747 4306799 FTH_1151 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763651.1 1132553 D 393011 CDS YP_763652.1 115314929 4306800 complement(1132757..1134109) 1 NC_008369.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 1134109 trmE 4306800 trmE Francisella tularensis subsp. holarctica OSU18 tRNA modification GTPase TrmE YP_763652.1 1132757 R 393011 CDS YP_763653.1 115314930 4306801 complement(1134115..1134252) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1134252 4306801 FTH_1153 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763653.1 1134115 R 393011 CDS YP_763654.1 115314931 4306802 1134290..1134382 1 NC_008369.1 hypothetical protein 1134382 4306802 FTH_1154 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763654.1 1134290 D 393011 CDS YP_763655.1 115314932 4306803 1134479..1134775 1 NC_008369.1 sigma 54 modulation protein/SE30A ribosomal protein 1134775 4306803 FTH_1155 Francisella tularensis subsp. holarctica OSU18 sigma 54 modulation protein/SE30A ribosomal protein YP_763655.1 1134479 D 393011 CDS YP_763656.1 115314933 4306804 1134812..1135267 1 NC_008369.1 SSPTS family porter component IIA 1135267 4306804 FTH_1156 Francisella tularensis subsp. holarctica OSU18 SSPTS family porter component IIA YP_763656.1 1134812 D 393011 CDS YP_763657.1 115314934 4306805 1135260..1136003 1 NC_008369.1 rRNA methyltransferase 1136003 lasT 4306805 lasT Francisella tularensis subsp. holarctica OSU18 rRNA methyltransferase YP_763657.1 1135260 D 393011 CDS YP_763658.1 115314935 4306806 1136005..1136568 1 NC_008369.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1136568 rnhB 4306806 rnhB Francisella tularensis subsp. holarctica OSU18 ribonuclease HII YP_763658.1 1136005 D 393011 CDS YP_763659.1 115314936 4306807 1136561..1137832 1 NC_008369.1 SSS family solute/sodium (Na+) symporter 1137832 4306807 FTH_1159 Francisella tularensis subsp. holarctica OSU18 SSS family solute/sodium (Na+) symporter YP_763659.1 1136561 D 393011 CDS YP_763660.1 115314937 4306808 complement(1137829..1138236) 1 NC_008369.1 stringent starvation protein subunit B; ClpXP protease specificity-enhancing factor 1138236 mglB 4306808 mglB Francisella tularensis subsp. holarctica OSU18 ClpXP protease specificity-enhancing factor YP_763660.1 1137829 R 393011 CDS YP_763661.1 115314938 4306809 complement(1138238..1138855) 1 NC_008369.1 stringent starvation protein subunit A; macrophage growth locus protein subunit A 1138855 mglA 4306809 mglA Francisella tularensis subsp. holarctica OSU18 macrophage growth locus protein subunit A YP_763661.1 1138238 R 393011 CDS YP_763662.2 394894297 4306810 complement(1138915..1139304) 1 NC_008369.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 1139304 rpsI 4306810 rpsI Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S9 YP_763662.2 1138915 R 393011 CDS YP_763663.1 115314940 4306811 complement(1139320..1139748) 1 NC_008369.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 1139748 rplM 4306811 rplM Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L13 YP_763663.1 1139320 R 393011 CDS YP_763664.1 115314941 4306812 complement(1139887..1141071) 1 NC_008369.1 hypothetical protein 1141071 hemY 4306812 hemY Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763664.1 1139887 R 393011 CDS YP_763665.1 115314942 4306813 complement(1141064..1142230) 1 NC_008369.1 membrane-bound murein transglycosylase 1142230 mltA 4306813 mltA Francisella tularensis subsp. holarctica OSU18 membrane-bound murein transglycosylase YP_763665.1 1141064 R 393011 CDS YP_763666.1 115314943 4306814 1142319..1142906 1 NC_008369.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 1142906 grpE 4306814 grpE Francisella tularensis subsp. holarctica OSU18 heat shock protein GrpE YP_763666.1 1142319 D 393011 CDS YP_763667.1 115314944 4306815 1143007..1144935 1 NC_008369.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 1144935 dnaK 4306815 dnaK Francisella tularensis subsp. holarctica OSU18 molecular chaperone DnaK YP_763667.1 1143007 D 393011 CDS YP_763668.1 115314945 4306816 1144961..1146139 1 NC_008369.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 1146139 dnaJ2 4306816 dnaJ2 Francisella tularensis subsp. holarctica OSU18 chaperone protein DnaJ YP_763668.1 1144961 D 393011 CDS YP_763669.1 115314946 4306817 complement(1146153..1146941) 1 NC_008369.1 LysR family transcriptional regulator 1146941 4306817 FTH_1169 Francisella tularensis subsp. holarctica OSU18 LysR family transcriptional regulator YP_763669.1 1146153 R 393011 CDS YP_763670.1 115314947 4306818 1147034..1147282 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1147282 4306818 FTH_1170 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763670.1 1147034 D 393011 CDS YP_763671.1 115314948 4306819 join(1147306..1147635,1147635..1148186) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1148186 isftu1 4306819 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763671.1 1147306 D 393011 CDS YP_763672.1 115314949 4306820 1148213..1149070 1 NC_008369.1 DMT superfamily drug/metabolite transporter 1149070 4306820 FTH_1172 Francisella tularensis subsp. holarctica OSU18 DMT superfamily drug/metabolite transporter YP_763672.1 1148213 D 393011 CDS YP_763673.1 115314950 4306821 1149156..1150169 1 NC_008369.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1150169 pheS 4306821 pheS Francisella tularensis subsp. holarctica OSU18 phenylalanyl-tRNA synthetase subunit alpha YP_763673.1 1149156 D 393011 CDS YP_763674.1 115314951 4306822 1150190..1152562 1 NC_008369.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1152562 pheT 4306822 pheT Francisella tularensis subsp. holarctica OSU18 phenylalanyl-tRNA synthetase subunit beta YP_763674.1 1150190 D 393011 CDS YP_763675.1 115314952 4306823 complement(1152605..1153036) 1 NC_008369.1 ferric (Fe3+) uptake regulator protein 1153036 fur1 4306823 fur1 Francisella tularensis subsp. holarctica OSU18 ferric (Fe3+) uptake regulator protein YP_763675.1 1152605 R 393011 CDS YP_763676.1 115314953 4306824 1153178..1154395 1 NC_008369.1 GTP-binding protein 1154395 4306824 FTH_1176 Francisella tularensis subsp. holarctica OSU18 GTP-binding protein YP_763676.1 1153178 D 393011 CDS YP_763677.1 115314954 4306825 1154398..1155144 1 NC_008369.1 ZIP family zinc (Zn2+)-iron (Fe2+) permease 1155144 zupT 4306825 zupT Francisella tularensis subsp. holarctica OSU18 ZIP family zinc (Zn2+)-iron (Fe2+) permease YP_763677.1 1154398 D 393011 CDS YP_763678.1 115314955 4306826 complement(1155166..1156155) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1156155 4306826 FTH_1178 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763678.1 1155166 R 393011 CDS YP_763679.1 115314956 4306827 complement(1156323..1157753) 1 NC_008369.1 cardiolipin synthase 1157753 4306827 FTH_1179 Francisella tularensis subsp. holarctica OSU18 cardiolipin synthase YP_763679.1 1156323 R 393011 CDS YP_763680.1 115314957 4306828 complement(1157845..1159272) 1 NC_008369.1 cardiolipin synthase 1159272 4306828 FTH_1180 Francisella tularensis subsp. holarctica OSU18 cardiolipin synthase YP_763680.1 1157845 R 393011 CDS YP_763681.1 115314958 4306830 1160653..1161513 1 NC_008369.1 chromosome partitioning ATPase 1161513 4306830 FTH_1182 Francisella tularensis subsp. holarctica OSU18 chromosome partitioning ATPase YP_763681.1 1160653 D 393011 CDS YP_763682.1 115314959 4306831 1161525..1162091 1 NC_008369.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1162091 dcd 4306831 dcd Francisella tularensis subsp. holarctica OSU18 deoxycytidine triphosphate deaminase YP_763682.1 1161525 D 393011 CDS YP_763683.1 115314960 4306833 complement(1163348..1163923) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1163923 4306833 FTH_1185 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763683.1 1163348 R 393011 CDS YP_763684.1 115314961 4306834 complement(1163931..1166372) 1 NC_008369.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 1166372 leuS 4306834 leuS Francisella tularensis subsp. holarctica OSU18 leucyl-tRNA synthetase YP_763684.1 1163931 R 393011 CDS YP_763685.1 115314962 4306835 complement(1166480..1168375) 1 NC_008369.1 hypothetical protein 1168375 4306835 FTH_1187 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763685.1 1166480 R 393011 CDS YP_763686.1 115314963 4306836 complement(1168387..1168485) 1 NC_008369.1 hypothetical protein 1168485 4306836 FTH_1188 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763686.1 1168387 R 393011 CDS YP_763687.1 115314964 4306837 complement(1168504..1168761) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1168761 4306837 FTH_1189 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763687.1 1168504 R 393011 CDS YP_763688.1 115314965 4306838 complement(1168884..1169009) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1169009 4306838 FTH_1190 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763688.1 1168884 R 393011 CDS YP_763689.1 115314966 4306839 complement(1168963..1169082) 1 NC_008369.1 hypothetical protein 1169082 4306839 FTH_1191 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763689.1 1168963 R 393011 CDS YP_763690.1 115314967 4306840 complement(1169175..1169585) 1 NC_008369.1 crossover junction endoribonuclease; hypothetical protein 1169585 4306840 FTH_1192 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763690.1 1169175 R 393011 CDS YP_763691.1 115314968 4306841 complement(1169587..1170171) 1 NC_008369.1 hypothetical protein 1170171 4306841 FTH_1193 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763691.1 1169587 R 393011 CDS YP_763692.1 115314969 4306843 complement(1170805..1171176) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1171176 4306843 FTH_1195 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763692.1 1170805 R 393011 CDS YP_763693.1 115314970 4306844 complement(1171857..1172981) 1 NC_008369.1 hypothetical protein 1172981 4306844 FTH_1196 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763693.1 1171857 R 393011 CDS YP_763694.1 115314971 4306845 complement(1173314..1174555) 1 NC_008369.1 hypothetical protein 1174555 4306845 FTH_1197 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763694.1 1173314 R 393011 CDS YP_763695.1 115314972 4306846 1174785..1176152 1 NC_008369.1 APC family amino acid-polyamine-organocation transporter 1176152 4306846 FTH_1198 Francisella tularensis subsp. holarctica OSU18 APC family amino acid-polyamine-organocation transporter YP_763695.1 1174785 D 393011 CDS YP_763696.1 115314973 4306847 1176204..1176809 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1176809 4306847 FTH_1199 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763696.1 1176204 D 393011 CDS YP_763697.1 115314974 4306848 1176813..1177106 1 NC_008369.1 transcriptional regulator 1177106 4306848 FTH_1200 Francisella tularensis subsp. holarctica OSU18 transcriptional regulator YP_763697.1 1176813 D 393011 CDS YP_763698.1 115314975 4306849 complement(1177231..1177512) 1 NC_008369.1 hypothetical protein 1177512 4306849 FTH_1201 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763698.1 1177231 R 393011 CDS YP_763699.1 115314976 4306850 complement(1177505..1177831) 1 NC_008369.1 thioredoxin 1177831 trxA2 4306850 trxA2 Francisella tularensis subsp. holarctica OSU18 thioredoxin YP_763699.1 1177505 R 393011 CDS YP_763700.1 115314977 4306851 complement(1177835..1178524) 1 NC_008369.1 hypothetical protein 1178524 4306851 FTH_1203 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763700.1 1177835 R 393011 CDS YP_763701.1 115314978 4306853 complement(1179491..1180645) 1 NC_008369.1 ABC transporter ATP-binding protein 1180645 4306853 FTH_1205 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_763701.1 1179491 R 393011 CDS YP_763702.1 115314979 4306854 complement(1180649..1181398) 1 NC_008369.1 ABC transporter ATP-binding protein 1181398 4306854 FTH_1206 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_763702.1 1180649 R 393011 CDS YP_763703.1 115314980 4306855 complement(1181437..1182882) 1 NC_008369.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 1182882 4306855 FTH_1207 Francisella tularensis subsp. holarctica OSU18 cysteine desulfurase activator complex subunit SufB YP_763703.1 1181437 R 393011 CDS YP_763704.1 115314981 4306856 complement(1182889..1183299) 1 NC_008369.1 transcriptional regulator 1183299 4306856 FTH_1208 Francisella tularensis subsp. holarctica OSU18 transcriptional regulator YP_763704.1 1182889 R 393011 CDS YP_763705.1 115314982 4306857 1183452..1184825 1 NC_008369.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 1184825 trkA 4306857 trkA Francisella tularensis subsp. holarctica OSU18 potassium transporter peripheral membrane protein YP_763705.1 1183452 D 393011 CDS YP_763706.1 115314983 4306858 1184884..1186305 1 NC_008369.1 APC family amino acid-polyamine-organocation transporter 1186305 4306858 FTH_1210 Francisella tularensis subsp. holarctica OSU18 APC family amino acid-polyamine-organocation transporter YP_763706.1 1184884 D 393011 CDS YP_763707.1 115314984 4306859 1186310..1186696 1 NC_008369.1 hypothetical protein 1186696 4306859 FTH_1211 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763707.1 1186310 D 393011 CDS YP_763708.1 115314985 4306860 1186689..1187237 1 NC_008369.1 hypothetical protein 1187237 4306860 FTH_1212 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763708.1 1186689 D 393011 CDS YP_763709.1 115314986 4306861 complement(1187267..1187485) 1 NC_008369.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1187485 infA 4306861 infA Francisella tularensis subsp. holarctica OSU18 translation initiation factor IF-1 YP_763709.1 1187267 R 393011 CDS YP_763710.1 115314987 4306862 1187579..1188484 1 NC_008369.1 hypothetical protein 1188484 4306862 FTH_1214 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763710.1 1187579 D 393011 CDS YP_763711.1 115314988 4306863 1188481..1188747 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1188747 4306863 FTH_1215 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763711.1 1188481 D 393011 CDS YP_763712.1 115314989 4306864 1188828..1190204 1 NC_008369.1 type II general secretory pathway signal recognition particle protein Ffh 1190204 ffh 4306864 ffh Francisella tularensis subsp. holarctica OSU18 type II general secretory pathway signal recognition particle protein Ffh YP_763712.1 1188828 D 393011 CDS YP_763713.1 115314990 4306865 1190236..1191348 1 NC_008369.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1191348 aroG 4306865 aroG Francisella tularensis subsp. holarctica OSU18 phospho-2-dehydro-3-deoxyheptonate aldolase YP_763713.1 1190236 D 393011 CDS YP_763714.1 115314991 4306867 complement(join(1191536..1192087,1192087..1192416)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1192416 isftu1 4306867 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763714.1 1191536 R 393011 CDS YP_763715.1 115314992 4306868 complement(1192664..1192996) 1 NC_008369.1 hypothetical protein 1192996 4306868 FTH_1220 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763715.1 1192664 R 393011 CDS YP_763716.1 115314993 4306869 1193278..1194066 1 NC_008369.1 similar to Escherichia coli exonuclease III; exodeoxyribonuclease III 1194066 xthA 4306869 xthA Francisella tularensis subsp. holarctica OSU18 exodeoxyribonuclease III YP_763716.1 1193278 D 393011 CDS YP_763717.1 115314994 4306870 1194087..1194794 1 NC_008369.1 short chain dehydrogenase 1194794 4306870 FTH_1222 Francisella tularensis subsp. holarctica OSU18 short chain dehydrogenase YP_763717.1 1194087 D 393011 CDS YP_763718.1 115314995 4306871 1194797..1195300 1 NC_008369.1 kinase 1195300 4306871 FTH_1223 Francisella tularensis subsp. holarctica OSU18 kinase YP_763718.1 1194797 D 393011 CDS YP_763719.1 115314996 4306872 1195300..1196019 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1196019 4306872 FTH_1224 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763719.1 1195300 D 393011 CDS YP_763720.1 115314997 4306873 1196057..1197418 1 NC_008369.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 1197418 gor 4306873 gor Francisella tularensis subsp. holarctica OSU18 glutathione reductase YP_763720.1 1196057 D 393011 CDS YP_763721.1 115314998 4306874 1197429..1197749 1 NC_008369.1 hypothetical protein 1197749 4306874 FTH_1226 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763721.1 1197429 D 393011 CDS YP_763722.1 115314999 4306876 1198745..1200286 1 NC_008369.1 POT family proton dependent peptide transporter 1200286 4306876 FTH_1228 Francisella tularensis subsp. holarctica OSU18 POT family proton dependent peptide transporter YP_763722.1 1198745 D 393011 CDS YP_763723.1 115315000 4307515 complement(1200283..1201608) 1 NC_008369.1 ATP-dependent RNA helicase 1201608 rhlE 4307515 rhlE Francisella tularensis subsp. holarctica OSU18 ATP-dependent RNA helicase YP_763723.1 1200283 R 393011 CDS YP_763724.1 115315001 4307516 1201735..1202355 1 NC_008369.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 1202355 folE 4307516 folE Francisella tularensis subsp. holarctica OSU18 GTP cyclohydrolase I YP_763724.1 1201735 D 393011 CDS YP_763725.1 115315002 4307517 1202586..1203062 1 NC_008369.1 hypothetical protein 1203062 4307517 FTH_1231 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763725.1 1202586 D 393011 CDS YP_763726.1 115315003 4307518 1203202..1203633 1 NC_008369.1 hypothetical protein 1203633 4307518 FTH_1232 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763726.1 1203202 D 393011 CDS YP_763727.1 115315004 4307520 1204752..1205756 1 NC_008369.1 oxidoreductase 1205756 4307520 FTH_1234 Francisella tularensis subsp. holarctica OSU18 oxidoreductase YP_763727.1 1204752 D 393011 CDS YP_763728.1 115315005 4307522 complement(1206977..1207531) 1 NC_008369.1 anthranilate synthase component II 1207531 trpG1 4307522 trpG1 Francisella tularensis subsp. holarctica OSU18 anthranilate synthase component II YP_763728.1 1206977 R 393011 CDS YP_763729.1 115315006 4307523 complement(1207533..1209296) 1 NC_008369.1 anthranilate synthase component I; anthranilate synthase 1209296 trpE1 4307523 trpE1 Francisella tularensis subsp. holarctica OSU18 anthranilate synthase YP_763729.1 1207533 R 393011 CDS YP_763730.1 115315007 4307524 complement(1209289..1210671) 1 NC_008369.1 acyl-activating enzyme; long-chain-fatty-acid--CoA ligase 1210671 fadD2 4307524 fadD2 Francisella tularensis subsp. holarctica OSU18 long-chain-fatty-acid--CoA ligase YP_763730.1 1209289 R 393011 CDS YP_763731.1 115315008 4307525 1210741..1211094 1 NC_008369.1 dihydroneopterin aldolase 1211094 folB 4307525 folB Francisella tularensis subsp. holarctica OSU18 dihydroneopterin aldolase YP_763731.1 1210741 D 393011 CDS YP_763732.1 115315009 4307526 1211096..1212361 1 NC_008369.1 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase 1212361 folK/folP 4307526 folK/folP Francisella tularensis subsp. holarctica OSU18 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase YP_763732.1 1211096 D 393011 CDS YP_763733.1 115315010 4307527 1212374..1213294 1 NC_008369.1 esterase 1213294 4307527 FTH_1241 Francisella tularensis subsp. holarctica OSU18 esterase YP_763733.1 1212374 D 393011 CDS YP_763734.1 115315011 4307528 1213310..1213810 1 NC_008369.1 hypothetical protein 1213810 4307528 FTH_1242 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763734.1 1213310 D 393011 CDS YP_763735.1 115315012 4307530 complement(1214972..1216258) 1 NC_008369.1 7,8-diamino-pelargonic acid aminotransferase; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1216258 bioA 4307530 bioA Francisella tularensis subsp. holarctica OSU18 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_763735.1 1214972 R 393011 CDS YP_763736.1 115315013 4307531 1216349..1217290 1 NC_008369.1 biotin synthetase; biotin synthase 1217290 bioB 4307531 bioB Francisella tularensis subsp. holarctica OSU18 biotin synthase YP_763736.1 1216349 D 393011 CDS YP_763737.1 115315014 4307532 1217284..1218411 1 NC_008369.1 7-KAP synthetase; 8-amino-7-oxononanoate synthase 1218411 bioF 4307532 bioF Francisella tularensis subsp. holarctica OSU18 8-amino-7-oxononanoate synthase YP_763737.1 1217284 D 393011 CDS YP_763738.1 115315015 4307533 1218389..1219126 1 NC_008369.1 biotin synthesis protein BioC 1219126 bioC 4307533 bioC Francisella tularensis subsp. holarctica OSU18 biotin synthesis protein BioC YP_763738.1 1218389 D 393011 CDS YP_763739.1 115315016 4307534 1219130..1219789 1 NC_008369.1 DTB synthetase; dethiobiotin synthetase 1219789 bioD 4307534 bioD Francisella tularensis subsp. holarctica OSU18 dethiobiotin synthetase YP_763739.1 1219130 D 393011 CDS YP_763740.1 115315017 4307535 complement(1219897..1220712) 1 NC_008369.1 acetyl-CoA carboxylase biotin holoenzyme synthetase; biotin--[acetyl-CoA-carboxylase] ligase 1220712 birA1 4307535 birA1 Francisella tularensis subsp. holarctica OSU18 biotin--[acetyl-CoA-carboxylase] ligase YP_763740.1 1219897 R 393011 CDS YP_763741.1 115315018 4307536 complement(1220735..1221619) 1 NC_008369.1 ROK family protein 1221619 4307536 FTH_1250 Francisella tularensis subsp. holarctica OSU18 ROK family protein YP_763741.1 1220735 R 393011 CDS YP_763742.1 115315019 4307538 1223331..1223885 1 NC_008369.1 converts acetoacetate to acetone and carbon dioxide; acetoacetate decarboxylase 1223885 adc 4307538 adc Francisella tularensis subsp. holarctica OSU18 acetoacetate decarboxylase YP_763742.1 1223331 D 393011 CDS YP_763743.1 115315020 4307540 1224750..1226417 1 NC_008369.1 beta-hexosaminidase; beta-N-acetylhexosaminidase 1226417 4307540 FTH_1254 Francisella tularensis subsp. holarctica OSU18 beta-N-acetylhexosaminidase YP_763743.1 1224750 D 393011 CDS YP_763744.1 115315021 4307541 complement(1226438..1227733) 1 NC_008369.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 1227733 hemL 4307541 hemL Francisella tularensis subsp. holarctica OSU18 glutamate-1-semialdehyde aminotransferase YP_763744.1 1226438 R 393011 CDS YP_763745.1 115315022 4307542 complement(1227723..1228697) 1 NC_008369.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 1228697 gshB 4307542 gshB Francisella tularensis subsp. holarctica OSU18 glutathione synthetase YP_763745.1 1227723 R 393011 CDS YP_763746.1 115315023 4307543 complement(1228701..1229642) 1 NC_008369.1 formylmethionyl-transfer ribonucleic synthetase; methionyl-tRNA formyltransferase 1229642 fmt 4307543 fmt Francisella tularensis subsp. holarctica OSU18 methionyl-tRNA formyltransferase YP_763746.1 1228701 R 393011 CDS YP_763747.1 115315024 4307544 complement(1229647..1230045) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1230045 4307544 FTH_1258 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763747.1 1229647 R 393011 CDS YP_763748.1 115315025 4307545 complement(1230147..1232300) 1 NC_008369.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1232300 rlmL 4307545 rlmL Francisella tularensis subsp. holarctica OSU18 23S rRNA m(2)G2445 methyltransferase YP_763748.1 1230147 R 393011 CDS YP_763749.1 115315026 4307546 complement(1232375..1232929) 1 NC_008369.1 fatty acid hydroxylase 1232929 4307546 FTH_1260 Francisella tularensis subsp. holarctica OSU18 fatty acid hydroxylase YP_763749.1 1232375 R 393011 CDS YP_763750.1 115315027 4307549 1233650..1233772 1 NC_008369.1 hypothetical protein 1233772 4307549 FTH_1262 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763750.1 1233650 D 393011 CDS YP_763751.1 115315028 4307550 complement(1233894..1234403) 1 NC_008369.1 hypothetical protein 1234403 4307550 FTH_1263 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763751.1 1233894 R 393011 CDS YP_763752.1 115315029 4307551 complement(join(1234360..1234911,1234911..1235240)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1235240 isftu1 4307551 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763752.1 1234360 R 393011 CDS YP_763753.1 115315030 4307553 1236505..1236975 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1236975 4307553 FTH_1266 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763753.1 1236505 D 393011 CDS YP_763754.1 115315031 4307554 1237112..1237936 1 NC_008369.1 short-chain dehydrogenase/reductase; oxidoreductase 1237936 4307554 FTH_1267 Francisella tularensis subsp. holarctica OSU18 oxidoreductase YP_763754.1 1237112 D 393011 CDS YP_763755.1 115315032 4307556 complement(1239543..1240415) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1240415 4307556 FTH_1269 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763755.1 1239543 R 393011 CDS YP_763756.1 115315033 4307557 join(1240583..1240912,1240912..1241463) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1241463 isftu1 4307557 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763756.1 1240583 D 393011 CDS YP_763757.1 115315034 4307558 complement(1241491..1241940) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1241940 4307558 FTH_1271 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763757.1 1241491 R 393011 CDS YP_763758.1 115315035 4307559 complement(1241949..1242344) 1 NC_008369.1 hypothetical protein 1242344 4307559 FTH_1272 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763758.1 1241949 R 393011 CDS YP_763759.1 115315036 4307561 1243285..1244016 1 NC_008369.1 phenol hydroxylase; phenol 2-monooxygenase 1244016 poxF 4307561 poxF Francisella tularensis subsp. holarctica OSU18 phenol 2-monooxygenase YP_763759.1 1243285 D 393011 CDS YP_763760.2 162139938 4307562 1244138..1244356 1 NC_008369.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1244356 rpmE 4307562 rpmE Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L31 YP_763760.2 1244138 D 393011 CDS YP_763761.1 115315038 4307563 complement(1244565..1246070) 1 NC_008369.1 gamma-glutamyl-L-cysteine synthetase; glutamate--cysteine ligase 1246070 gshA 4307563 gshA Francisella tularensis subsp. holarctica OSU18 glutamate--cysteine ligase YP_763761.1 1244565 R 393011 CDS YP_763762.1 115315039 4307564 complement(1246123..1247664) 1 NC_008369.1 virulence factor transporter MviN 1247664 mviN 4307564 mviN Francisella tularensis subsp. holarctica OSU18 virulence factor transporter MviN YP_763762.1 1246123 R 393011 CDS YP_763763.1 115315040 4307565 complement(1247725..1248756) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1248756 4307565 FTH_1278 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763763.1 1247725 R 393011 CDS YP_763764.1 115315041 4307566 complement(1248839..1249249) 1 NC_008369.1 ATP-binding protein 1249249 4307566 FTH_1279 Francisella tularensis subsp. holarctica OSU18 ATP-binding protein YP_763764.1 1248839 R 393011 CDS YP_763765.1 115315042 4307567 complement(1249227..1250408) 1 NC_008369.1 7,8-dihydrofolate synthetase; dihydrofolate synthase 1250408 folC 4307567 folC Francisella tularensis subsp. holarctica OSU18 dihydrofolate synthase YP_763765.1 1249227 R 393011 CDS YP_763766.1 115315043 4306339 complement(1250423..1251331) 1 NC_008369.1 acetyl-CoA carboxylase subunit beta 1251331 accD 4306339 accD Francisella tularensis subsp. holarctica OSU18 acetyl-CoA carboxylase subunit beta YP_763766.1 1250423 R 393011 CDS YP_763767.1 115315044 4306340 complement(1251367..1251789) 1 NC_008369.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1251789 ndk 4306340 ndk Francisella tularensis subsp. holarctica OSU18 nucleoside diphosphate kinase YP_763767.1 1251367 R 393011 CDS YP_763768.1 115315045 4306341 complement(1251862..1253502) 1 NC_008369.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1253502 pyrG 4306341 pyrG Francisella tularensis subsp. holarctica OSU18 CTP synthetase YP_763768.1 1251862 R 393011 CDS YP_763769.1 115315046 4306343 complement(1255601..1256533) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1256533 4306343 FTH_1285 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763769.1 1255601 R 393011 CDS YP_763770.1 115315047 4306344 join(1256980..1257309,1257309..1257860) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1257860 isftu1 4306344 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763770.1 1256980 D 393011 CDS YP_763771.1 115315048 4306345 complement(1258056..1259021) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1259021 4306345 FTH_1287 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763771.1 1258056 R 393011 CDS YP_763772.1 115315049 4306347 complement(1260307..1260885) 1 NC_008369.1 hypothetical protein 1260885 4306347 FTH_1289 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763772.1 1260307 R 393011 CDS YP_763773.1 115315050 4306348 complement(1260866..1261159) 1 NC_008369.1 hypothetical protein 1261159 4306348 FTH_1290 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763773.1 1260866 R 393011 CDS YP_763774.1 115315051 4306351 complement(1267838..1269019) 1 NC_008369.1 outer membrane protein FopA 1269019 fopA 4306351 fopA Francisella tularensis subsp. holarctica OSU18 outer membrane protein FopA YP_763774.1 1267838 R 393011 CDS YP_763775.1 115315052 4306352 complement(1269126..1269371) 1 NC_008369.1 ferredoxin 1269371 fdx 4306352 fdx Francisella tularensis subsp. holarctica OSU18 ferredoxin YP_763775.1 1269126 R 393011 CDS YP_763776.1 115315053 4306353 complement(1269376..1269864) 1 NC_008369.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1269864 coaD 4306353 coaD Francisella tularensis subsp. holarctica OSU18 phosphopantetheine adenylyltransferase YP_763776.1 1269376 R 393011 CDS YP_763777.1 115315054 4306354 complement(1269876..1270427) 1 NC_008369.1 hypothetical protein 1270427 4306354 FTH_1296 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763777.1 1269876 R 393011 CDS YP_763778.1 115315055 4306355 complement(1270441..1270797) 1 NC_008369.1 HesB family protein 1270797 4306355 FTH_1297 Francisella tularensis subsp. holarctica OSU18 HesB family protein YP_763778.1 1270441 R 393011 CDS YP_763779.1 115315056 4306356 complement(1270818..1272041) 1 NC_008369.1 selenocysteine beta-lyase; selenocysteine lyase 1272041 csdB 4306356 csdB Francisella tularensis subsp. holarctica OSU18 selenocysteine lyase YP_763779.1 1270818 R 393011 CDS YP_763780.1 115315057 4306357 complement(1272144..1273517) 1 NC_008369.1 L-hydroxyaminoacid dehydratase; L-serine ammonia-lyase 1273517 sdaA/tdcB 4306357 sdaA/tdcB Francisella tularensis subsp. holarctica OSU18 L-serine ammonia-lyase YP_763780.1 1272144 R 393011 CDS YP_763781.1 115315058 4306358 complement(1273573..1274241) 1 NC_008369.1 hypothetical protein 1274241 4306358 FTH_1300 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763781.1 1273573 R 393011 CDS YP_763782.1 115315059 4306359 complement(1274267..1275109) 1 NC_008369.1 prephenate dehydratase 1275109 pheA 4306359 pheA Francisella tularensis subsp. holarctica OSU18 prephenate dehydratase YP_763782.1 1274267 R 393011 CDS YP_763783.1 115315060 4306361 complement(1276885..1277982) 1 NC_008369.1 alanine racemase 1277982 alr 4306361 alr Francisella tularensis subsp. holarctica OSU18 alanine racemase YP_763783.1 1276885 R 393011 CDS YP_763784.1 115315061 4306363 complement(1279608..1280315) 1 NC_008369.1 hypothetical protein 1280315 4306363 FTH_1305 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763784.1 1279608 R 393011 CDS YP_763785.1 115315062 4306364 complement(1280327..1280725) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1280725 4306364 FTH_1306 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763785.1 1280327 R 393011 CDS YP_763786.1 115315063 4306365 1280805..1281827 1 NC_008369.1 hypothetical protein 1281827 4306365 FTH_1307 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763786.1 1280805 D 393011 CDS YP_763787.1 115315064 4306371 complement(1286784..1288868) 1 NC_008369.1 glycyl translase; glycine--tRNA ligase 1288868 glyS 4306371 glyS Francisella tularensis subsp. holarctica OSU18 glycine--tRNA ligase YP_763787.1 1286784 R 393011 CDS YP_763788.1 115315065 4306372 1289061..1289735 1 NC_008369.1 TatD family deoxyribonuclease 1289735 4306372 FTH_1314 Francisella tularensis subsp. holarctica OSU18 TatD family deoxyribonuclease YP_763788.1 1289061 D 393011 CDS YP_763789.1 115315066 4307717 1289739..1290788 1 NC_008369.1 DNA replication and repair protein RecF 1290788 recF 4307717 recF Francisella tularensis subsp. holarctica OSU18 DNA replication and repair protein RecF YP_763789.1 1289739 D 393011 CDS YP_763790.1 115315067 4307719 1291133..1291339 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1291339 4307719 FTH_1317 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763790.1 1291133 D 393011 CDS YP_763791.1 115315068 4307720 complement(1291342..1292259) 1 NC_008369.1 hypothetical protein 1292259 4307720 FTH_1318 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763791.1 1291342 R 393011 CDS YP_763792.1 115315069 4307722 complement(1293732..1294595) 1 NC_008369.1 glucose-1-phosphate uridylyltransferase; UTP--glucose-1-phosphate uridylyltransferase 1294595 galU 4307722 galU Francisella tularensis subsp. holarctica OSU18 UTP--glucose-1-phosphate uridylyltransferase YP_763792.1 1293732 R 393011 CDS YP_763793.1 115315070 4307723 complement(1294612..1295751) 1 NC_008369.1 hypothetical protein 1295751 4307723 FTH_1321 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763793.1 1294612 R 393011 CDS YP_763794.1 115315071 4307724 complement(1295842..1296411) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1296411 4307724 FTH_1322 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763794.1 1295842 R 393011 CDS YP_763795.1 115315072 4307727 complement(1297279..1297479) 1 NC_008369.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1297479 rpsU 4307727 rpsU Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S21 YP_763795.1 1297279 R 393011 CDS YP_763796.1 115315073 4307728 1297856..1298053 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1298053 4307728 FTH_1325 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763796.1 1297856 D 393011 CDS YP_763797.1 115315074 4307729 1298252..1298455 1 NC_008369.1 cold shock protein 1298455 cspA 4307729 cspA Francisella tularensis subsp. holarctica OSU18 cold shock protein YP_763797.1 1298252 D 393011 CDS YP_763798.1 115315075 4307730 complement(1298526..1299512) 1 NC_008369.1 hypothetical protein 1299512 4307730 FTH_1327 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763798.1 1298526 R 393011 CDS YP_763799.1 115315076 4307731 1299702..1300700 1 NC_008369.1 hypothetical protein 1300700 4307731 FTH_1328 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763799.1 1299702 D 393011 CDS YP_763800.1 115315077 4307732 complement(1300724..1301443) 1 NC_008369.1 transcriptional regulator 1301443 4307732 FTH_1329 Francisella tularensis subsp. holarctica OSU18 transcriptional regulator YP_763800.1 1300724 R 393011 CDS YP_763801.1 115315078 4307733 1301642..1301842 1 NC_008369.1 hypothetical protein 1301842 4307733 FTH_1330 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763801.1 1301642 D 393011 CDS YP_763802.1 115315079 4307735 1302682..1303485 1 NC_008369.1 hypothetical protein 1303485 4307735 FTH_1332 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763802.1 1302682 D 393011 CDS YP_763803.1 115315080 4307736 1303582..1304073 1 NC_008369.1 hypothetical protein 1304073 4307736 FTH_1333 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763803.1 1303582 D 393011 CDS YP_763804.1 115315081 4307737 complement(join(1304170..1304721,1304721..1305050)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1305050 isftu1 4307737 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763804.1 1304170 R 393011 CDS YP_763805.1 115315082 4307738 complement(1305426..1306241) 1 NC_008369.1 hypothetical protein 1306241 4307738 FTH_1335 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763805.1 1305426 R 393011 CDS YP_763806.1 115315083 4307739 1306681..1306914 1 NC_008369.1 hypothetical protein 1306914 4307739 FTH_1336 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763806.1 1306681 D 393011 CDS YP_763807.1 115315084 4307742 1312344..1312712 1 NC_008369.1 ribosome-associated heat shock protein Hsp15; heat shock protein 15 (HSP15) 1312712 hslR 4307742 hslR Francisella tularensis subsp. holarctica OSU18 heat shock protein 15 (HSP15) YP_763807.1 1312344 D 393011 CDS YP_763808.1 115315085 4307743 complement(1312747..1314240) 1 NC_008369.1 sugar kinase 1314240 4307743 FTH_1340 Francisella tularensis subsp. holarctica OSU18 sugar kinase YP_763808.1 1312747 R 393011 CDS YP_763809.1 115315086 4307744 1314408..1314536 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1314536 4307744 FTH_1341 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763809.1 1314408 D 393011 CDS YP_763810.1 115315087 4307745 complement(1314547..1315167) 1 NC_008369.1 hypothetical protein 1315167 4307745 FTH_1342 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763810.1 1314547 R 393011 CDS YP_763811.1 115315088 4307748 complement(1317498..1317968) 1 NC_008369.1 glutathione peroxidase 1317968 4307748 FTH_1345 Francisella tularensis subsp. holarctica OSU18 glutathione peroxidase YP_763811.1 1317498 R 393011 CDS YP_763812.1 115315089 4307749 complement(1317997..1318287) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1318287 4307749 FTH_1346 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763812.1 1317997 R 393011 CDS YP_763813.1 115315090 4307750 1318441..1318887 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1318887 4307750 FTH_1347 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763813.1 1318441 D 393011 CDS YP_763814.1 115315091 4307753 complement(1320976..1322463) 1 NC_008369.1 L-aspartate oxidase 1322463 nadB 4307753 nadB Francisella tularensis subsp. holarctica OSU18 L-aspartate oxidase YP_763814.1 1320976 R 393011 CDS YP_763815.1 115315092 4307754 complement(1322466..1323329) 1 NC_008369.1 nicotinate-nucleotide pyrophosphorylase (carboxylating); nicotinate-nucleotide diphosphorylase (carboxylating) 1323329 nadC 4307754 nadC Francisella tularensis subsp. holarctica OSU18 nicotinate-nucleotide diphosphorylase (carboxylating) YP_763815.1 1322466 R 393011 CDS YP_763816.1 115315093 4307755 complement(1323338..1324363) 1 NC_008369.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 1324363 nadA 4307755 nadA Francisella tularensis subsp. holarctica OSU18 quinolinate synthetase YP_763816.1 1323338 R 393011 CDS YP_763817.1 115315094 4307756 complement(1324384..1324956) 1 NC_008369.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1324956 gmk 4307756 gmk Francisella tularensis subsp. holarctica OSU18 guanylate kinase YP_763817.1 1324384 R 393011 CDS YP_763818.1 115315095 4307757 complement(1325073..1326782) 1 NC_008369.1 ATP-dependent RNA helicase 1326782 4307757 FTH_1354 Francisella tularensis subsp. holarctica OSU18 ATP-dependent RNA helicase YP_763818.1 1325073 R 393011 CDS YP_763819.1 115315096 4307758 complement(1326817..1327095) 1 NC_008369.1 cyclophilin; peptidyl-prolyl isomerase 1327095 4307758 FTH_1355 Francisella tularensis subsp. holarctica OSU18 peptidyl-prolyl isomerase YP_763819.1 1326817 R 393011 CDS YP_763820.1 115315097 4307761 1330087..1331112 1 NC_008369.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 1331112 galT 4307761 galT Francisella tularensis subsp. holarctica OSU18 galactose-1-phosphate uridylyltransferase YP_763820.1 1330087 D 393011 CDS YP_763821.1 115315098 4307762 1331115..1332263 1 NC_008369.1 galactokinase 1332263 galK 4307762 galK Francisella tularensis subsp. holarctica OSU18 galactokinase YP_763821.1 1331115 D 393011 CDS YP_763822.1 115315099 4307763 complement(1332260..1332655) 1 NC_008369.1 hypothetical protein 1332655 4307763 FTH_1360 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763822.1 1332260 R 393011 CDS YP_763823.1 115315100 4307764 complement(1332648..1333400) 1 NC_008369.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1333400 kdsB 4307764 kdsB Francisella tularensis subsp. holarctica OSU18 3-deoxy-manno-octulosonate cytidylyltransferase YP_763823.1 1332648 R 393011 CDS YP_763824.1 115315101 4307765 complement(1333393..1333581) 1 NC_008369.1 hypothetical protein 1333581 4307765 FTH_1362 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763824.1 1333393 R 393011 CDS YP_763825.1 115315102 4307767 complement(join(1334210..1334761,1334761..1335090)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1335090 isftu1 4307767 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763825.1 1334210 R 393011 CDS YP_763826.1 115315103 4307768 complement(1335382..1336086) 1 NC_008369.1 hypothetical protein 1336086 4307768 FTH_1365 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763826.1 1335382 R 393011 CDS YP_763827.1 115315104 4307769 complement(1336128..1336484) 1 NC_008369.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1336484 rplT 4307769 rplT Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L20 YP_763827.1 1336128 R 393011 CDS YP_763828.1 115315105 4307770 complement(1336520..1336717) 1 NC_008369.1 50S ribosomal protein L35 1336717 rpmI 4307770 rpmI Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L35 YP_763828.1 1336520 R 393011 CDS YP_763829.1 115315106 4307771 complement(1336760..1337227) 1 NC_008369.1 elongation factor (EF); protein-synthesizing GTPase 1337227 infC 4307771 infC Francisella tularensis subsp. holarctica OSU18 protein-synthesizing GTPase YP_763829.1 1336760 R 393011 CDS YP_763830.1 115315107 4307772 complement(1337303..1339207) 1 NC_008369.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1339207 thrS 4307772 thrS Francisella tularensis subsp. holarctica OSU18 threonyl-tRNA synthetase YP_763830.1 1337303 R 393011 CDS YP_763831.1 115315108 4307773 1339714..1341438 1 NC_008369.1 conserved in Francisella genomes; multifunctional chitinase 1341438 4307773 FTH_1370 Francisella tularensis subsp. holarctica OSU18 multifunctional chitinase YP_763831.1 1339714 D 393011 CDS YP_763832.1 115315109 4307774 complement(1341524..1341820) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1341820 4307774 FTH_1371 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763832.1 1341524 R 393011 CDS YP_763833.1 115315110 4307775 complement(1341810..1342190) 1 NC_008369.1 glycine cleavage system protein H 1342190 gcvH2 4307775 gcvH2 Francisella tularensis subsp. holarctica OSU18 glycine cleavage system protein H YP_763833.1 1341810 R 393011 CDS YP_763834.1 115315111 4307776 1342294..1343409 1 NC_008369.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 1343409 murG 4307776 murG Francisella tularensis subsp. holarctica OSU18 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_763834.1 1342294 D 393011 CDS YP_763835.1 115315112 4307777 1343419..1343757 1 NC_008369.1 hypothetical protein 1343757 4307777 FTH_1374 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763835.1 1343419 D 393011 CDS YP_763836.1 115315113 4307778 1343757..1344359 1 NC_008369.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1344359 recR 4307778 recR Francisella tularensis subsp. holarctica OSU18 recombination protein RecR YP_763836.1 1343757 D 393011 CDS YP_763837.1 115315114 4307779 complement(1344367..1346490) 1 NC_008369.1 (ppGpp)ase; guanosine-3',5'-bis(diphosphate) 3'-diphosphatase 1346490 spoT2 4307779 spoT2 Francisella tularensis subsp. holarctica OSU18 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase YP_763837.1 1344367 R 393011 CDS YP_763838.1 115315115 4307780 complement(1346550..1347761) 1 NC_008369.1 hypothetical protein 1347761 4307780 FTH_1377 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763838.1 1346550 R 393011 CDS YP_763839.1 115315116 4307781 complement(1347763..1348227) 1 NC_008369.1 capsule biosynthesis protein CapC 1348227 4307781 FTH_1378 Francisella tularensis subsp. holarctica OSU18 capsule biosynthesis protein CapC YP_763839.1 1347763 R 393011 CDS YP_763840.1 115315117 4307782 complement(1348252..1349469) 1 NC_008369.1 probable poly-gamma-glutamate synthesis protein; capsule biosynthesis protein 1349469 4307782 FTH_1379 Francisella tularensis subsp. holarctica OSU18 capsule biosynthesis protein YP_763840.1 1348252 R 393011 CDS YP_763841.1 115315118 4307783 complement(1349545..1350801) 1 NC_008369.1 major facilitator transporter 1350801 4307783 FTH_1380 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_763841.1 1349545 R 393011 CDS YP_763842.1 115315119 4307789 complement(1351473..1352336) 1 NC_008369.1 L-asparaginase; asparaginase 1352336 ans 4307789 ans Francisella tularensis subsp. holarctica OSU18 asparaginase YP_763842.1 1351473 R 393011 CDS YP_763843.1 115315120 4307790 complement(1352552..1353370) 1 NC_008369.1 possible cyanophycinase; peptidase 1353370 4307790 FTH_1382 Francisella tularensis subsp. holarctica OSU18 peptidase YP_763843.1 1352552 R 393011 CDS YP_763844.1 115315121 4307791 1353573..1354679 1 NC_008369.1 sugar kinase 1354679 4307791 FTH_1383 Francisella tularensis subsp. holarctica OSU18 sugar kinase YP_763844.1 1353573 D 393011 CDS YP_763845.1 115315122 4307792 complement(1354961..1355623) 1 NC_008369.1 HAD superfamily haloacid dehalogenase hydrolase 1355623 4307792 FTH_1384 Francisella tularensis subsp. holarctica OSU18 HAD superfamily haloacid dehalogenase hydrolase YP_763845.1 1354961 R 393011 CDS YP_763846.1 115315123 4307793 complement(1355642..1356655) 1 NC_008369.1 glycosyl transferases group 1 family protein 1356655 4307793 FTH_1385 Francisella tularensis subsp. holarctica OSU18 glycosyl transferases group 1 family protein YP_763846.1 1355642 R 393011 CDS YP_763847.1 115315124 4307794 complement(1356658..1357665) 1 NC_008369.1 glycosyltransferase 1357665 4307794 FTH_1386 Francisella tularensis subsp. holarctica OSU18 glycosyltransferase YP_763847.1 1356658 R 393011 CDS YP_763848.1 115315125 4307795 complement(1357682..1358641) 1 NC_008369.1 glycosyltransferase 1358641 4307795 FTH_1387 Francisella tularensis subsp. holarctica OSU18 glycosyltransferase YP_763848.1 1357682 R 393011 CDS YP_763849.1 115315126 4307796 complement(1358650..1359411) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1359411 4307796 FTH_1388 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763849.1 1358650 R 393011 CDS YP_763850.1 115315127 4307797 complement(1359415..1360098) 1 NC_008369.1 hypothetical protein 1360098 4307797 FTH_1389 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763850.1 1359415 R 393011 CDS YP_763851.1 115315128 4307798 complement(1360037..1361323) 1 NC_008369.1 bifunctional phosphoserine phosphatase/sugar nucleotidyltransferase 1361323 4307798 FTH_1390 Francisella tularensis subsp. holarctica OSU18 bifunctional phosphoserine phosphatase/sugar nucleotidyltransferase YP_763851.1 1360037 R 393011 CDS YP_763852.1 115315129 4307799 complement(1361337..1363028) 1 NC_008369.1 ABC transporter ATP-binding protein 1363028 4307799 FTH_1391 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_763852.1 1361337 R 393011 CDS YP_763853.1 115315130 4307800 complement(1363025..1364254) 1 NC_008369.1 glycosyltransferase I (outer core) 1364254 waaG 4307800 waaG Francisella tularensis subsp. holarctica OSU18 glycosyltransferase I (outer core) YP_763853.1 1363025 R 393011 CDS YP_763854.1 115315131 4307801 complement(1364258..1365277) 1 NC_008369.1 galactowaldenase; UDP-glucose 4-epimerase 1365277 galE 4307801 galE Francisella tularensis subsp. holarctica OSU18 UDP-glucose 4-epimerase YP_763854.1 1364258 R 393011 CDS YP_763855.1 115315132 4307802 complement(1365270..1366664) 1 NC_008369.1 sugar transferase 1366664 4307802 FTH_1394 Francisella tularensis subsp. holarctica OSU18 sugar transferase YP_763855.1 1365270 R 393011 CDS YP_763856.1 115315133 4307803 complement(1366645..1367313) 1 NC_008369.1 D-ribulose phosphate-3-epimerase; D-ribulose-phosphate 3-epimerase 1367313 rpe 4307803 rpe Francisella tularensis subsp. holarctica OSU18 D-ribulose-phosphate 3-epimerase YP_763856.1 1366645 R 393011 CDS YP_763857.1 115315134 4307804 1367438..1368421 1 NC_008369.1 arabinose phosphate isomerase; arabinose-5-phosphate isomerase 1368421 kdsD 4307804 kdsD Francisella tularensis subsp. holarctica OSU18 arabinose-5-phosphate isomerase YP_763857.1 1367438 D 393011 CDS YP_763858.1 115315135 4307805 complement(1368425..1369015) 1 NC_008369.1 hypothetical protein 1369015 4307805 FTH_1397 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763858.1 1368425 R 393011 CDS YP_763859.1 115315136 4307808 complement(1370525..1370854) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1370854 4307808 FTH_1400 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763859.1 1370525 R 393011 CDS YP_763860.1 115315137 4307811 complement(1372832..1373614) 1 NC_008369.1 enoyl-ACP reductase; enoyl-[acyl-carrier-protein] reductase (NADH) 1373614 fabI 4307811 fabI Francisella tularensis subsp. holarctica OSU18 enoyl-[acyl-carrier-protein] reductase (NADH) YP_763860.1 1372832 R 393011 CDS YP_763861.1 115315138 4307812 1373900..1374613 1 NC_008369.1 hypothetical protein 1374613 4307812 FTH_1404 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763861.1 1373900 D 393011 CDS YP_763862.1 115315139 4307813 1374603..1374872 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1374872 4307813 FTH_1405 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763862.1 1374603 D 393011 CDS YP_763863.1 115315140 4307816 complement(1376856..1377230) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1377230 4307816 FTH_1409 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763863.1 1376856 R 393011 CDS YP_763864.1 115315141 4307817 complement(1377297..1379135) 1 NC_008369.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1379135 uvrC 4307817 uvrC Francisella tularensis subsp. holarctica OSU18 excinuclease ABC subunit C YP_763864.1 1377297 R 393011 CDS YP_763865.1 115315142 4307818 1379244..1380338 1 NC_008369.1 RNase D; ribonuclease III 1380338 rnd 4307818 rnd Francisella tularensis subsp. holarctica OSU18 ribonuclease III YP_763865.1 1379244 D 393011 CDS YP_763866.1 115315143 4307819 1380367..1381581 1 NC_008369.1 major facilitator transporter 1381581 4307819 FTH_1412 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_763866.1 1380367 D 393011 CDS YP_763867.1 115315144 4307820 complement(1381578..1381955) 1 NC_008369.1 hypothetical protein 1381955 4307820 FTH_1413 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763867.1 1381578 R 393011 CDS YP_763868.1 115315145 4307821 complement(1382342..1382596) 1 NC_008369.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1382596 rpmA 4307821 rpmA Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L27 YP_763868.1 1382342 R 393011 CDS YP_763869.1 115315146 4307822 complement(1382627..1382941) 1 NC_008369.1 50S ribosomal protein L21 1382941 rplU 4307822 rplU Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L21 YP_763869.1 1382627 R 393011 CDS YP_763870.1 115315147 4307825 complement(1385004..1387724) 1 NC_008369.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1387724 secA 4307825 secA Francisella tularensis subsp. holarctica OSU18 preprotein translocase subunit SecA YP_763870.1 1385004 R 393011 CDS YP_763871.1 115315148 4307826 1387892..1388884 1 NC_008369.1 hypothetical protein 1388884 4307826 FTH_1419 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763871.1 1387892 D 393011 CDS YP_763872.1 115315149 4307827 1388888..1389337 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1389337 4307827 FTH_1420 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763872.1 1388888 D 393011 CDS YP_763873.1 115315150 4307828 complement(1389334..1390056) 1 NC_008369.1 inosine phosphorylase; purine nucleoside phosphorylase 1390056 deoD 4307828 deoD Francisella tularensis subsp. holarctica OSU18 purine nucleoside phosphorylase YP_763873.1 1389334 R 393011 CDS YP_763874.1 115315151 4307829 complement(join(1390129..1390680,1390680..1391009)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1391009 isftu1 4307829 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763874.1 1390129 R 393011 CDS YP_763875.1 115315152 4307831 complement(1392037..1393983) 1 NC_008369.1 M41 family endopeptidase FtsH/HflB 1393983 ftsH/hflB 4307831 ftsH/hflB Francisella tularensis subsp. holarctica OSU18 M41 family endopeptidase FtsH/HflB YP_763875.1 1392037 R 393011 CDS YP_763876.1 115315153 4307834 complement(1396443..1399265) 1 NC_008369.1 UvrABC excinuclease subunit A 1399265 uvrA 4307834 uvrA Francisella tularensis subsp. holarctica OSU18 UvrABC excinuclease subunit A YP_763876.1 1396443 R 393011 CDS YP_763877.1 115315154 4307835 complement(1399304..1399786) 1 NC_008369.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1399786 greA 4307835 greA Francisella tularensis subsp. holarctica OSU18 transcription elongation factor GreA YP_763877.1 1399304 R 393011 CDS YP_763878.1 115315155 4307836 complement(1399820..1400404) 1 NC_008369.1 type IV pilus assembly protein 1400404 4307836 FTH_1429 Francisella tularensis subsp. holarctica OSU18 type IV pilus assembly protein YP_763878.1 1399820 R 393011 CDS YP_763879.1 115315156 4307837 complement(1400405..1402030) 1 NC_008369.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1402030 pgi 4307837 pgi Francisella tularensis subsp. holarctica OSU18 glucose-6-phosphate isomerase YP_763879.1 1400405 R 393011 CDS YP_763880.1 115315157 4307838 complement(1402017..1402670) 1 NC_008369.1 thiamine kinase; thiamine diphosphokinase 1402670 4307838 FTH_1431 Francisella tularensis subsp. holarctica OSU18 thiamine diphosphokinase YP_763880.1 1402017 R 393011 CDS YP_763881.1 115315158 4307839 complement(1402736..1404196) 1 NC_008369.1 IMP oxidoreductase; IMP dehydrogenase 1404196 guaB 4307839 guaB Francisella tularensis subsp. holarctica OSU18 IMP dehydrogenase YP_763881.1 1402736 R 393011 CDS YP_763882.1 115315159 4307840 complement(1404297..1405736) 1 NC_008369.1 cytosol aminopeptidase 1405736 pepA 4307840 pepA Francisella tularensis subsp. holarctica OSU18 cytosol aminopeptidase YP_763882.1 1404297 R 393011 CDS YP_763883.1 115315160 4307841 1405902..1406984 1 NC_008369.1 hypothetical protein 1406984 4307841 FTH_1434 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763883.1 1405902 D 393011 CDS YP_763884.1 115315161 4307842 1406984..1408045 1 NC_008369.1 hypothetical protein 1408045 4307842 FTH_1435 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763884.1 1406984 D 393011 CDS YP_763885.1 115315162 4307843 1408053..1409306 1 NC_008369.1 M16 family peptidase 1409306 4307843 FTH_1436 Francisella tularensis subsp. holarctica OSU18 M16 family peptidase YP_763885.1 1408053 D 393011 CDS YP_763886.1 115315163 4307844 1409313..1410536 1 NC_008369.1 M16 family peptidase 1410536 4307844 FTH_1437 Francisella tularensis subsp. holarctica OSU18 M16 family peptidase YP_763886.1 1409313 D 393011 CDS YP_763887.1 115315164 4307845 1410537..1411115 1 NC_008369.1 N6-adenine-specific methyltransferase 1411115 4307845 FTH_1438 Francisella tularensis subsp. holarctica OSU18 N6-adenine-specific methyltransferase YP_763887.1 1410537 D 393011 CDS YP_763888.1 115315165 4307846 1411149..1411799 1 NC_008369.1 hypothetical protein 1411799 4307846 FTH_1439 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763888.1 1411149 D 393011 CDS YP_763889.1 115315166 4307847 complement(1411852..1412463) 1 NC_008369.1 tRNA-(ms(2)io(6)a)-hydroxylase 1412463 miaE 4307847 miaE Francisella tularensis subsp. holarctica OSU18 tRNA-(ms(2)io(6)a)-hydroxylase YP_763889.1 1411852 R 393011 CDS YP_763890.1 115315167 4307848 1412578..1413381 1 NC_008369.1 pyrimidine phosphorylase; uridine phosphorylase 1413381 udp 4307848 udp Francisella tularensis subsp. holarctica OSU18 uridine phosphorylase YP_763890.1 1412578 D 393011 CDS YP_763891.1 115315168 4307849 1413402..1413803 1 NC_008369.1 cytidine aminohydrolase; cytidine deaminase 1413803 cdd 4307849 cdd Francisella tularensis subsp. holarctica OSU18 cytidine deaminase YP_763891.1 1413402 D 393011 CDS YP_763892.1 115315169 4307851 complement(1413995..1417030) 1 NC_008369.1 bifunctional FAD/FMN dehydrogenase/Fe-S oxidoreductase 1417030 4307851 FTH_1443 Francisella tularensis subsp. holarctica OSU18 bifunctional FAD/FMN dehydrogenase/Fe-S oxidoreductase YP_763892.1 1413995 R 393011 CDS YP_763893.1 115315170 4307852 1417237..1418787 1 NC_008369.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 1418787 gpmI 4307852 gpmI Francisella tularensis subsp. holarctica OSU18 phosphoglyceromutase YP_763893.1 1417237 D 393011 CDS YP_763894.1 115315171 4307853 1418802..1420082 1 NC_008369.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1420082 serS 4307853 serS Francisella tularensis subsp. holarctica OSU18 seryl-tRNA synthetase YP_763894.1 1418802 D 393011 CDS YP_763895.1 115315172 4307854 1420192..1421091 1 NC_008369.1 D-fructokinase; fructokinase 1421091 4307854 FTH_1446 Francisella tularensis subsp. holarctica OSU18 fructokinase YP_763895.1 1420192 D 393011 CDS YP_763896.1 115315173 4307855 1421169..1422428 1 NC_008369.1 MOP/MATE superfamily multidrug/oligosaccharidyl-lipid/polysaccharide flippase 1422428 4307855 FTH_1447 Francisella tularensis subsp. holarctica OSU18 MOP/MATE superfamily multidrug/oligosaccharidyl-lipid/polysaccharide flippase YP_763896.1 1421169 D 393011 CDS YP_763897.1 115315174 4307856 complement(1422432..1422632) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1422632 4307856 FTH_1448 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763897.1 1422432 R 393011 CDS YP_763898.1 115315175 4307857 complement(1422660..1423169) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1423169 4307857 FTH_1449 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763898.1 1422660 R 393011 CDS YP_763899.1 115315176 4307858 1423546..1425327 1 NC_008369.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1425327 cydD 4307858 cydD Francisella tularensis subsp. holarctica OSU18 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_763899.1 1423546 D 393011 CDS YP_763900.1 115315177 4307859 1425324..1426973 1 NC_008369.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1426973 cydC 4307859 cydC Francisella tularensis subsp. holarctica OSU18 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_763900.1 1425324 D 393011 CDS YP_763901.1 115315178 4307860 complement(1426975..1428225) 1 NC_008369.1 DAACS family dicarboxylate/amino acid:sodium or proton symporter 1428225 dctA 4307860 dctA Francisella tularensis subsp. holarctica OSU18 DAACS family dicarboxylate/amino acid:sodium or proton symporter YP_763901.1 1426975 R 393011 CDS YP_763902.1 115315179 4307861 complement(1428364..1428744) 1 NC_008369.1 translation initiation inhibitor; endoribonuclease L-PSP 1428744 tdcF 4307861 tdcF Francisella tularensis subsp. holarctica OSU18 endoribonuclease L-PSP YP_763902.1 1428364 R 393011 CDS YP_763903.1 115315180 4307862 complement(1428744..1430288) 1 NC_008369.1 SulP family sulfate permease 1430288 4307862 FTH_1454 Francisella tularensis subsp. holarctica OSU18 SulP family sulfate permease YP_763903.1 1428744 R 393011 CDS YP_763904.1 115315181 4307864 1431274..1432497 1 NC_008369.1 proline/betaine transporter; major facilitator transporter 1432497 4307864 FTH_1456 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_763904.1 1431274 D 393011 CDS YP_763905.1 115315182 4307865 complement(1432481..1433806) 1 NC_008369.1 deoxy-GTPase; dGTPase 1433806 dgt 4307865 dgt Francisella tularensis subsp. holarctica OSU18 dGTPase YP_763905.1 1432481 R 393011 CDS YP_763906.1 115315183 4307866 complement(1433910..1436135) 1 NC_008369.1 catalase 1436135 katG 4307866 katG Francisella tularensis subsp. holarctica OSU18 catalase YP_763906.1 1433910 R 393011 CDS YP_763907.1 115315184 4307867 complement(join(1436904..1437455,1437455..1437784)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1437784 isftu1 4307867 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763907.1 1436904 R 393011 CDS YP_763908.1 115315185 4307869 complement(1438866..1440260) 1 NC_008369.1 possible D-Ala-D-Ala carboxypeptidase C; peptidase 1440260 4307869 FTH_1461 Francisella tularensis subsp. holarctica OSU18 peptidase YP_763908.1 1438866 R 393011 CDS YP_763909.1 115315186 4307870 complement(1440276..1441592) 1 NC_008369.1 major facilitator superfamily glycerol-3-phosphate uniporter 1441592 glpT 4307870 glpT Francisella tularensis subsp. holarctica OSU18 major facilitator superfamily glycerol-3-phosphate uniporter YP_763909.1 1440276 R 393011 CDS YP_763910.1 115315187 4307871 complement(1441699..1442733) 1 NC_008369.1 glycerophosphoryl diester phosphodiesterase; glycerophosphodiester phosphodiesterase 1442733 ugpQ 4307871 ugpQ Francisella tularensis subsp. holarctica OSU18 glycerophosphodiester phosphodiesterase YP_763910.1 1441699 R 393011 CDS YP_763911.1 115315188 4307873 1443833..1444765 1 NC_008369.1 ABC transporter ATP-binding protein 1444765 4307873 FTH_1465 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_763911.1 1443833 D 393011 CDS YP_763912.1 115315189 4307876 complement(1446762..1447106) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1447106 4307876 FTH_1468 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763912.1 1446762 R 393011 CDS YP_763913.1 115315190 4307878 complement(1448113..1448757) 1 NC_008369.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 1448757 upp 4307878 upp Francisella tularensis subsp. holarctica OSU18 uracil phosphoribosyltransferase YP_763913.1 1448113 R 393011 CDS YP_763914.1 115315191 4307879 complement(1448934..1451216) 1 NC_008369.1 chitinase 1451216 4307879 FTH_1471 Francisella tularensis subsp. holarctica OSU18 chitinase YP_763914.1 1448934 R 393011 CDS YP_763915.1 115315192 4307880 1451733..1452947 1 NC_008369.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 1452947 kbl 4307880 kbl Francisella tularensis subsp. holarctica OSU18 2-amino-3-ketobutyrate coenzyme A ligase YP_763915.1 1451733 D 393011 CDS YP_763916.1 115315193 4307881 1452970..1454025 1 NC_008369.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 1454025 tdh 4307881 tdh Francisella tularensis subsp. holarctica OSU18 L-threonine 3-dehydrogenase YP_763916.1 1452970 D 393011 CDS YP_763917.1 115315194 4307882 1454027..1455172 1 NC_008369.1 HAAAP family serine permease 1455172 4307882 FTH_1474 Francisella tularensis subsp. holarctica OSU18 HAAAP family serine permease YP_763917.1 1454027 D 393011 CDS YP_763918.1 115315195 4307883 complement(1455296..1455985) 1 NC_008369.1 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1455985 ispD 4307883 ispD Francisella tularensis subsp. holarctica OSU18 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_763918.1 1455296 R 393011 CDS YP_763919.1 115315196 4307884 complement(1455975..1456265) 1 NC_008369.1 cell division initiator protein FtsB 1456265 ftsB 4307884 ftsB Francisella tularensis subsp. holarctica OSU18 cell division initiator protein FtsB YP_763919.1 1455975 R 393011 CDS YP_763920.1 115315197 4307885 complement(1456273..1457643) 1 NC_008369.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1457643 eno 4307885 eno Francisella tularensis subsp. holarctica OSU18 phosphopyruvate hydratase YP_763920.1 1456273 R 393011 CDS YP_763921.1 115315198 4307886 complement(1457752..1459005) 1 NC_008369.1 major facilitator transporter 1459005 4307886 FTH_1478 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_763921.1 1457752 R 393011 CDS YP_763922.1 115315199 4307887 complement(1459093..1459887) 1 NC_008369.1 nicotinamide mononucleotide transporter 1459887 4307887 FTH_1479 Francisella tularensis subsp. holarctica OSU18 nicotinamide mononucleotide transporter YP_763922.1 1459093 R 393011 CDS YP_763923.1 115315200 4307888 complement(1459970..1460605) 1 NC_008369.1 bifunctional transcriptional regulator/sugar kinase 1460605 4307888 FTH_1480 Francisella tularensis subsp. holarctica OSU18 bifunctional transcriptional regulator/sugar kinase YP_763923.1 1459970 R 393011 CDS YP_763924.1 115315201 4307889 complement(1460615..1461964) 1 NC_008369.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 1461964 rumA 4307889 rumA Francisella tularensis subsp. holarctica OSU18 23S rRNA 5-methyluridine methyltransferase YP_763924.1 1460615 R 393011 CDS YP_763925.1 115315202 4307890 complement(1462053..1462625) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1462625 4307890 FTH_1482 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763925.1 1462053 R 393011 CDS YP_763926.1 115315203 4307892 complement(1462890..1463108) 1 NC_008369.1 DNA-dependent RNA polymerase; DNA-directed RNA polymerase 1463108 rpoZ 4307892 rpoZ Francisella tularensis subsp. holarctica OSU18 DNA-directed RNA polymerase YP_763926.1 1462890 R 393011 CDS YP_763927.1 115315204 4307893 complement(1463101..1463766) 1 NC_008369.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1463766 udk 4307893 udk Francisella tularensis subsp. holarctica OSU18 uridine kinase YP_763927.1 1463101 R 393011 CDS YP_763928.1 115315205 4307894 complement(1463777..1464625) 1 NC_008369.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1464625 kdsA 4307894 kdsA Francisella tularensis subsp. holarctica OSU18 2-dehydro-3-deoxyphosphooctonate aldolase YP_763928.1 1463777 R 393011 CDS YP_763929.1 115315206 4307895 complement(1464635..1464985) 1 NC_008369.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 1464985 4307895 FTH_1486 Francisella tularensis subsp. holarctica OSU18 iron-sulfur cluster insertion protein ErpA YP_763929.1 1464635 R 393011 CDS YP_763930.1 115315207 4307896 complement(1464991..1467072) 1 NC_008369.1 polynucleotide phosphorylase; polynucleotide phosphorylase/polyadenylase 1467072 pnp 4307896 pnp Francisella tularensis subsp. holarctica OSU18 polynucleotide phosphorylase/polyadenylase YP_763930.1 1464991 R 393011 CDS YP_763931.1 115315208 4307897 complement(1467129..1467395) 1 NC_008369.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1467395 rpsO 4307897 rpsO Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S15 YP_763931.1 1467129 R 393011 CDS YP_763932.1 115315209 4307898 complement(1467501..1469195) 1 NC_008369.1 penicillin binding protein (3 or 1B); peptidoglycan glycosyltransferase 1469195 ftsI 4307898 ftsI Francisella tularensis subsp. holarctica OSU18 peptidoglycan glycosyltransferase YP_763932.1 1467501 R 393011 CDS YP_763933.1 115315210 4307899 complement(1469188..1469538) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1469538 4307899 FTH_1490 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763933.1 1469188 R 393011 CDS YP_763934.1 115315211 4307900 complement(1469535..1470452) 1 NC_008369.1 S-adenosyl-methyltransferase MraW 1470452 mraW 4307900 mraW Francisella tularensis subsp. holarctica OSU18 S-adenosyl-methyltransferase MraW YP_763934.1 1469535 R 393011 CDS YP_763935.1 115315212 4307901 complement(1470458..1472557) 1 NC_008369.1 acyl-coenzyme A synthetase 1472557 4307901 FTH_1492 Francisella tularensis subsp. holarctica OSU18 acyl-coenzyme A synthetase YP_763935.1 1470458 R 393011 CDS YP_763936.1 115315213 4307902 1472650..1473474 1 NC_008369.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 1473474 mutM 4307902 mutM Francisella tularensis subsp. holarctica OSU18 formamidopyrimidine-DNA glycosylase YP_763936.1 1472650 D 393011 CDS YP_763937.1 115315214 4307903 join(1473545..1473874,1473874..1474425) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1474425 isftu1 4307903 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763937.1 1473545 D 393011 CDS YP_763938.2 229575956 4307904 complement(1474433..1474972) 1 NC_008369.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 1474972 4307904 FTH_1495 Francisella tularensis subsp. holarctica OSU18 glutamine amidotransferase subunit PdxT YP_763938.2 1474433 R 393011 CDS YP_763939.1 115315216 4307905 complement(1474975..1475838) 1 NC_008369.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 1475838 4307905 FTH_1496 Francisella tularensis subsp. holarctica OSU18 pyridoxal biosynthesis lyase PdxS YP_763939.1 1474975 R 393011 CDS YP_763940.1 115315217 4307906 complement(1475968..1478379) 1 NC_008369.1 DNA gyrase; DNA topoisomerase 1478379 gyrB 4307906 gyrB Francisella tularensis subsp. holarctica OSU18 DNA topoisomerase YP_763940.1 1475968 R 393011 CDS YP_763941.1 115315218 4307907 1478561..1479361 1 NC_008369.1 hypothetical protein 1479361 4307907 FTH_1498 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763941.1 1478561 D 393011 CDS YP_763942.1 115315219 4307908 1479395..1480378 1 NC_008369.1 tRNA-dihydrouridine synthase A 1480378 dusA 4307908 dusA Francisella tularensis subsp. holarctica OSU18 tRNA-dihydrouridine synthase A YP_763942.1 1479395 D 393011 CDS YP_763943.1 115315220 4307909 complement(1480385..1481152) 1 NC_008369.1 hypothetical protein 1481152 4307909 FTH_1500 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763943.1 1480385 R 393011 CDS YP_763944.1 115315221 4307910 complement(1481651..1481899) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1481899 4307910 FTH_1501 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763944.1 1481651 R 393011 CDS YP_763945.1 115315222 4307911 1481820..1482134 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1482134 4307911 FTH_1502 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763945.1 1481820 D 393011 CDS YP_763946.1 115315223 4307912 complement(1482142..1484055) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1484055 4307912 FTH_1503 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763946.1 1482142 R 393011 CDS YP_763947.1 115315224 4307913 1484225..1485388 1 NC_008369.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1485388 sucC 4307913 sucC Francisella tularensis subsp. holarctica OSU18 succinyl-CoA synthetase subunit beta YP_763947.1 1484225 D 393011 CDS YP_763948.1 115315225 4307914 1485420..1486292 1 NC_008369.1 succinate thiokinase; succinate--CoA ligase (ADP-forming) 1486292 sucD 4307914 sucD Francisella tularensis subsp. holarctica OSU18 succinate--CoA ligase (ADP-forming) YP_763948.1 1485420 D 393011 CDS YP_763949.1 115315226 4307915 1486402..1486827 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1486827 4307915 FTH_1506 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763949.1 1486402 D 393011 CDS YP_763950.1 115315227 4307916 complement(1486986..1487207) 1 NC_008369.1 hypothetical protein 1487207 4307916 FTH_1507 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763950.1 1486986 R 393011 CDS YP_763951.1 115315228 4307917 1487211..1488251 1 NC_008369.1 hypothetical protein 1488251 4307917 FTH_1508 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763951.1 1487211 D 393011 CDS YP_763952.1 115315229 4307918 complement(1488383..1489600) 1 NC_008369.1 alanine:alanine ligase (ADP-forming); D-alanine--D-alanine ligase 1489600 ddlA 4307918 ddlA Francisella tularensis subsp. holarctica OSU18 D-alanine--D-alanine ligase YP_763952.1 1488383 R 393011 CDS YP_763953.1 115315230 4307920 1491277..1492197 1 NC_008369.1 L-asparaginase; asparaginase 1492197 aspG 4307920 aspG Francisella tularensis subsp. holarctica OSU18 asparaginase YP_763953.1 1491277 D 393011 CDS YP_763954.1 115315231 4307923 1493787..1494509 1 NC_008369.1 CutC family copper (Cu2+) homeostasis protein 1494509 cutC 4307923 cutC Francisella tularensis subsp. holarctica OSU18 CutC family copper (Cu2+) homeostasis protein YP_763954.1 1493787 D 393011 CDS YP_763955.1 115315232 4307924 complement(1494524..1495690) 1 NC_008369.1 arabinose permease; major facilitator transporter 1495690 araJ 4307924 araJ Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_763955.1 1494524 R 393011 CDS YP_763956.1 115315233 4307925 1495801..1496727 1 NC_008369.1 LysR family transcriptional regulator 1496727 4307925 FTH_1516 Francisella tularensis subsp. holarctica OSU18 LysR family transcriptional regulator YP_763956.1 1495801 D 393011 CDS YP_763957.1 115315234 4307926 1496768..1497442 1 NC_008369.1 phosphoglycolate phosphatase 1497442 gph 4307926 gph Francisella tularensis subsp. holarctica OSU18 phosphoglycolate phosphatase YP_763957.1 1496768 D 393011 CDS YP_763958.1 115315235 4307928 1498794..1499744 1 NC_008369.1 NADP--thioredoxin reductase; thioredoxin reductase 1499744 trxB 4307928 trxB Francisella tularensis subsp. holarctica OSU18 thioredoxin reductase YP_763958.1 1498794 D 393011 CDS YP_763959.1 115315236 4307932 complement(1502895..1504697) 1 NC_008369.1 DNA mismatch repair protein 1504697 mutL 4307932 mutL Francisella tularensis subsp. holarctica OSU18 DNA mismatch repair protein YP_763959.1 1502895 R 393011 CDS YP_763960.1 115315237 4307934 complement(1505436..1506155) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1506155 4307934 FTH_1525 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763960.1 1505436 R 393011 CDS YP_763961.1 115315238 4307935 1506309..1507196 1 NC_008369.1 GTP-binding protein 1507196 4307935 FTH_1526 Francisella tularensis subsp. holarctica OSU18 GTP-binding protein YP_763961.1 1506309 D 393011 CDS YP_763962.1 115315239 4307936 1507415..1508230 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1508230 4307936 FTH_1527 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763962.1 1507415 D 393011 CDS YP_763963.1 115315240 4307937 complement(1508483..1509664) 1 NC_008369.1 putrescine ABC transporter ATP-binding protein 1509664 potF 4307937 potF Francisella tularensis subsp. holarctica OSU18 putrescine ABC transporter ATP-binding protein YP_763963.1 1508483 R 393011 CDS YP_763964.1 115315241 4307938 1509748..1511157 1 NC_008369.1 probable glutamate:gamma-aminobutyric acid transporter; gamma-glutamate APC transporter 1511157 xasA 4307938 xasA Francisella tularensis subsp. holarctica OSU18 gamma-glutamate APC transporter YP_763964.1 1509748 D 393011 CDS YP_763965.1 115315242 4307939 1511259..1512365 1 NC_008369.1 PerM family protein 1512365 4307939 FTH_1530 Francisella tularensis subsp. holarctica OSU18 PerM family protein YP_763965.1 1511259 D 393011 CDS YP_763966.1 115315243 4307940 1512359..1514101 1 NC_008369.1 single-stranded-DNA-specific exonuclease RecJ 1514101 recJ 4307940 recJ Francisella tularensis subsp. holarctica OSU18 single-stranded-DNA-specific exonuclease RecJ YP_763966.1 1512359 D 393011 CDS YP_763967.1 115315244 4307941 1514098..1514880 1 NC_008369.1 acetyl-CoA carboxylase biotin holoenzyme synthetase; biotin--[acetyl-CoA-carboxylase] ligase 1514880 birA2 4307941 birA2 Francisella tularensis subsp. holarctica OSU18 biotin--[acetyl-CoA-carboxylase] ligase YP_763967.1 1514098 D 393011 CDS YP_763968.1 115315245 4307942 1514877..1515800 1 NC_008369.1 lysine translase; lysine--tRNA ligase 1515800 poxA 4307942 poxA Francisella tularensis subsp. holarctica OSU18 lysine--tRNA ligase YP_763968.1 1514877 D 393011 CDS YP_763969.1 115315246 4306558 complement(1517809..1518489) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1518489 4306558 FTH_1536 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763969.1 1517809 R 393011 CDS YP_763970.1 115315247 4306559 complement(1518583..1519938) 1 NC_008369.1 acetyl-CoA carboxylase biotin carboxylase subunit 1519938 accC 4306559 accC Francisella tularensis subsp. holarctica OSU18 acetyl-CoA carboxylase biotin carboxylase subunit YP_763970.1 1518583 R 393011 CDS YP_763971.1 115315248 4306560 complement(1520003..1520476) 1 NC_008369.1 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 1520476 accB 4306560 accB Francisella tularensis subsp. holarctica OSU18 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_763971.1 1520003 R 393011 CDS YP_763972.1 115315249 4306561 complement(1520481..1520918) 1 NC_008369.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 1520918 aroD 4306561 aroD Francisella tularensis subsp. holarctica OSU18 3-dehydroquinate dehydratase YP_763972.1 1520481 R 393011 CDS YP_763973.1 115315250 4306562 complement(1520922..1521749) 1 NC_008369.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 1521749 apaH 4306562 apaH Francisella tularensis subsp. holarctica OSU18 diadenosine tetraphosphatase YP_763973.1 1520922 R 393011 CDS YP_763974.1 115315251 4306563 complement(1521761..1522549) 1 NC_008369.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1522549 ksgA 4306563 ksgA Francisella tularensis subsp. holarctica OSU18 dimethyladenosine transferase YP_763974.1 1521761 R 393011 CDS YP_763975.1 115315252 4306564 complement(1522551..1523978) 1 NC_008369.1 cyclophilin; peptidyl-prolyl isomerase 1523978 surA 4306564 surA Francisella tularensis subsp. holarctica OSU18 peptidyl-prolyl isomerase YP_763975.1 1522551 R 393011 CDS YP_763976.1 115315253 4306565 complement(1523960..1526566) 1 NC_008369.1 organic solvent tolerance protein 1526566 ostA 4306565 ostA Francisella tularensis subsp. holarctica OSU18 organic solvent tolerance protein YP_763976.1 1523960 R 393011 CDS YP_763977.1 115315254 4306566 1526692..1528437 1 NC_008369.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1528437 argS 4306566 argS Francisella tularensis subsp. holarctica OSU18 arginyl-tRNA synthetase YP_763977.1 1526692 D 393011 CDS YP_763978.1 115315255 4306567 complement(1528489..1528875) 1 NC_008369.1 hypothetical protein 1528875 4306567 FTH_1545 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763978.1 1528489 R 393011 CDS YP_763979.1 115315256 4306568 complement(1529294..1530214) 1 NC_008369.1 L-asparaginase; asparaginase 1530214 ansB 4306568 ansB Francisella tularensis subsp. holarctica OSU18 asparaginase YP_763979.1 1529294 R 393011 CDS YP_763980.1 115315257 4306569 complement(1530475..1530942) 1 NC_008369.1 tRNA/rRNA methyltransferase 1530942 yibK 4306569 yibK Francisella tularensis subsp. holarctica OSU18 tRNA/rRNA methyltransferase YP_763980.1 1530475 R 393011 CDS YP_763981.1 115315258 4306570 complement(1530946..1531920) 1 NC_008369.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 1531920 hemB 4306570 hemB Francisella tularensis subsp. holarctica OSU18 delta-aminolevulinic acid dehydratase YP_763981.1 1530946 R 393011 CDS YP_763982.1 115315259 4306571 complement(1531928..1532206) 1 NC_008369.1 RNA-binding protein 1532206 yhbY 4306571 yhbY Francisella tularensis subsp. holarctica OSU18 RNA-binding protein YP_763982.1 1531928 R 393011 CDS YP_763983.1 115315260 4306572 complement(1532217..1533128) 1 NC_008369.1 DNA nucleotidyltransferase (DNA-directed); DNA polymerase III, delta prime subunit 1533128 holB 4306572 holB Francisella tularensis subsp. holarctica OSU18 DNA polymerase III, delta prime subunit YP_763983.1 1532217 R 393011 CDS YP_763984.1 115315261 4306573 complement(1533136..1534152) 1 NC_008369.1 SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease 1534152 sohB 4306573 sohB Francisella tularensis subsp. holarctica OSU18 putative periplasmic protease YP_763984.1 1533136 R 393011 CDS YP_763985.1 115315262 4306574 complement(1534164..1534796) 1 NC_008369.1 glutathione S-transferase 1534796 gst 4306574 gst Francisella tularensis subsp. holarctica OSU18 glutathione S-transferase YP_763985.1 1534164 R 393011 CDS YP_763986.1 115315263 4306575 1534882..1535196 1 NC_008369.1 dissimilatory sulfite reductase subunit gamma 1535196 dsrC 4306575 dsrC Francisella tularensis subsp. holarctica OSU18 dissimilatory sulfite reductase subunit gamma YP_763986.1 1534882 D 393011 CDS YP_763987.1 115315264 4306576 1535187..1535480 1 NC_008369.1 hypothetical protein 1535480 4306576 FTH_1554 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763987.1 1535187 D 393011 CDS YP_763988.1 115315265 4306577 1535572..1537332 1 NC_008369.1 amylophosphorylase; phosphorylase 1537332 4306577 FTH_1555 Francisella tularensis subsp. holarctica OSU18 phosphorylase YP_763988.1 1535572 D 393011 CDS YP_763989.1 115315266 4306578 complement(join(1537617..1538168,1538168..1538497)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1538497 isftu1 4306578 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_763989.1 1537617 R 393011 CDS YP_763990.1 115315267 4306580 complement(1538656..1539612) 1 NC_008369.1 glycosyl transferase family protein 1539612 wcaA 4306580 wcaA Francisella tularensis subsp. holarctica OSU18 glycosyl transferase family protein YP_763990.1 1538656 R 393011 CDS YP_763991.1 115315268 4306581 1539711..1540517 1 NC_008369.1 hypothetical protein 1540517 4306581 FTH_1559 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763991.1 1539711 D 393011 CDS YP_763992.1 115315269 4306582 complement(1540525..1541730) 1 NC_008369.1 cell division protein FtsW 1541730 ftsW 4306582 ftsW Francisella tularensis subsp. holarctica OSU18 cell division protein FtsW YP_763992.1 1540525 R 393011 CDS YP_763993.1 115315270 4306583 complement(1541740..1542990) 1 NC_008369.1 D-glutamate ligase; UDP-N-acetylmuramoylalanine--D-glutamate ligase 1542990 murD 4306583 murD Francisella tularensis subsp. holarctica OSU18 UDP-N-acetylmuramoylalanine--D-glutamate ligase YP_763993.1 1541740 R 393011 CDS YP_763994.1 115315271 4306584 complement(1542990..1544087) 1 NC_008369.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1544087 mraY 4306584 mraY Francisella tularensis subsp. holarctica OSU18 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_763994.1 1542990 R 393011 CDS YP_763995.1 115315272 4306585 complement(1544162..1545754) 1 NC_008369.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 1545754 pckA 4306585 pckA Francisella tularensis subsp. holarctica OSU18 phosphoenolpyruvate carboxykinase YP_763995.1 1544162 R 393011 CDS YP_763996.1 115315273 4306586 1545899..1547545 1 NC_008369.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 1547545 glnS 4306586 glnS Francisella tularensis subsp. holarctica OSU18 glutaminyl-tRNA synthetase YP_763996.1 1545899 D 393011 CDS YP_763997.1 115315274 4306589 complement(1549595..1551436) 1 NC_008369.1 ABC transporter ATP-binding protein 1551436 4306589 FTH_1567 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_763997.1 1549595 R 393011 CDS YP_763998.1 115315275 4307301 complement(1551470..1552696) 1 NC_008369.1 major facilitator superfamily tetracycline exporter 1552696 tet 4307301 tet Francisella tularensis subsp. holarctica OSU18 major facilitator superfamily tetracycline exporter YP_763998.1 1551470 R 393011 CDS YP_763999.1 115315276 4307302 complement(1552779..1553822) 1 NC_008369.1 hypothetical protein 1553822 4307302 FTH_1569 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_763999.1 1552779 R 393011 CDS YP_764000.1 115315277 4307303 1554094..1555287 1 NC_008369.1 major facilitator superfamily bicyclomycin exporter 1555287 4307303 FTH_1570 Francisella tularensis subsp. holarctica OSU18 major facilitator superfamily bicyclomycin exporter YP_764000.1 1554094 D 393011 CDS YP_764001.1 115315278 4307304 1555317..1555961 1 NC_008369.1 hypothetical protein 1555961 4307304 FTH_1571 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764001.1 1555317 D 393011 CDS YP_764002.1 115315279 4307307 1557931..1559637 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1559637 4307307 FTH_1574 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764002.1 1557931 D 393011 CDS YP_764003.1 115315280 4307308 complement(join(1559638..1560189,1560189..1560518)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1; ISFtu1 transposase 1560518 isftu1 4307308 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_764003.1 1559638 R 393011 CDS YP_764004.1 115315281 4307310 complement(1561948..1562673) 1 NC_008369.1 hypothetical protein 1562673 4307310 FTH_1577 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764004.1 1561948 R 393011 CDS YP_764005.1 115315282 4307311 complement(1562854..1563849) 1 NC_008369.1 LysR family transcriptional regulator 1563849 4307311 FTH_1578 Francisella tularensis subsp. holarctica OSU18 LysR family transcriptional regulator YP_764005.1 1562854 R 393011 CDS YP_764006.1 115315283 4307312 1564386..1566500 1 NC_008369.1 chitinase 1566500 4307312 FTH_1579 Francisella tularensis subsp. holarctica OSU18 chitinase YP_764006.1 1564386 D 393011 CDS YP_764007.1 115315284 4307314 1569018..1569713 1 NC_008369.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 1569713 ubiG 4307314 ubiG Francisella tularensis subsp. holarctica OSU18 3-demethylubiquinone-9 3-methyltransferase YP_764007.1 1569018 D 393011 CDS YP_764008.1 115315285 4307315 1569716..1570459 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1570459 4307315 FTH_1582 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764008.1 1569716 D 393011 CDS YP_764009.1 115315286 4307316 1570456..1570692 1 NC_008369.1 hypothetical protein 1570692 4307316 FTH_1583 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764009.1 1570456 D 393011 CDS YP_764010.1 115315287 4307318 1572345..1572626 1 NC_008369.1 hypothetical protein 1572626 4307318 FTH_1585 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764010.1 1572345 D 393011 CDS YP_764011.1 115315288 4307319 complement(1572640..1572879) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1572879 4307319 FTH_1586 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764011.1 1572640 R 393011 CDS YP_764012.1 115315289 4307321 complement(1573746..1575254) 1 NC_008369.1 ATP:glycerol 3-phosphotransferase; glycerol kinase 1575254 glpK 4307321 glpK Francisella tularensis subsp. holarctica OSU18 glycerol kinase YP_764012.1 1573746 R 393011 CDS YP_764013.1 115315290 4307322 complement(1575323..1576579) 1 NC_008369.1 major facilitator transporter 1576579 4307322 FTH_1589 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_764013.1 1575323 R 393011 CDS YP_764014.1 115315291 4307323 complement(1576694..1577305) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1577305 4307323 FTH_1590 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764014.1 1576694 R 393011 CDS YP_764015.1 115315292 4307324 1577439..1578641 1 NC_008369.1 major facilitator transporter 1578641 4307324 FTH_1591 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_764015.1 1577439 D 393011 CDS YP_764016.1 115315293 4307330 complement(1584063..1586285) 1 NC_008369.1 DNA helicase II 1586285 uvrD2 4307330 uvrD2 Francisella tularensis subsp. holarctica OSU18 DNA helicase II YP_764016.1 1584063 R 393011 CDS YP_764017.1 115315294 4307331 complement(1586376..1587407) 1 NC_008369.1 signal recognition particle receptor FtsY 1587407 ftsY 4307331 ftsY Francisella tularensis subsp. holarctica OSU18 signal recognition particle receptor FtsY YP_764017.1 1586376 R 393011 CDS YP_764018.1 115315295 4307332 complement(1587404..1588720) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1588720 4307332 FTH_1599 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764018.1 1587404 R 393011 CDS YP_764019.1 115315296 4307333 complement(1588795..1590372) 1 NC_008369.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 1590372 prfC 4307333 prfC Francisella tularensis subsp. holarctica OSU18 peptide chain release factor 3 YP_764019.1 1588795 R 393011 CDS YP_764020.1 115315297 4307334 complement(1590434..1591063) 1 NC_008369.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1591063 tmk 4307334 tmk Francisella tularensis subsp. holarctica OSU18 thymidylate kinase YP_764020.1 1590434 R 393011 CDS YP_764021.1 115315298 4307335 complement(1591076..1592278) 1 NC_008369.1 CNT family concentrative nucleoside transporter, membrane protein 1592278 nupC1 4307335 nupC1 Francisella tularensis subsp. holarctica OSU18 CNT family concentrative nucleoside transporter, membrane protein YP_764021.1 1591076 R 393011 CDS YP_764022.1 115315299 4307336 complement(1592297..1593496) 1 NC_008369.1 nucleoside transporter 1593496 nupC2 4307336 nupC2 Francisella tularensis subsp. holarctica OSU18 nucleoside transporter YP_764022.1 1592297 R 393011 CDS YP_764023.1 115315300 4307337 complement(1593486..1594247) 1 NC_008369.1 deoxyriboaldolase; deoxyribose-phosphate aldolase 1594247 deoC 4307337 deoC Francisella tularensis subsp. holarctica OSU18 deoxyribose-phosphate aldolase YP_764023.1 1593486 R 393011 CDS YP_764024.1 115315301 4307338 complement(1594210..1595454) 1 NC_008369.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 1595454 deoB 4307338 deoB Francisella tularensis subsp. holarctica OSU18 phosphopentomutase YP_764024.1 1594210 R 393011 CDS YP_764025.1 115315302 4307339 complement(1595459..1596223) 1 NC_008369.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 1596223 4307339 FTH_1606 Francisella tularensis subsp. holarctica OSU18 pantothenate kinase YP_764025.1 1595459 R 393011 CDS YP_764026.1 115315303 4307340 complement(1596243..1598936) 1 NC_008369.1 DNA nucleotidyltransferase (DNA-directed); DNA polymerase I 1598936 polA 4307340 polA Francisella tularensis subsp. holarctica OSU18 DNA polymerase I YP_764026.1 1596243 R 393011 CDS YP_764027.1 115315304 4307341 complement(1599032..1600000) 1 NC_008369.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 1600000 lpxK 4307341 lpxK Francisella tularensis subsp. holarctica OSU18 tetraacyldisaccharide 4'-kinase YP_764027.1 1599032 R 393011 CDS YP_764028.1 115315305 4307342 complement(1600006..1601835) 1 NC_008369.1 ABC transporter ATP-binding protein 1601835 valA 4307342 valA Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_764028.1 1600006 R 393011 CDS YP_764029.1 115315306 4307343 1601940..1603022 1 NC_008369.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 1603022 cca 4307343 cca Francisella tularensis subsp. holarctica OSU18 tRNA CCA-pyrophosphorylase YP_764029.1 1601940 D 393011 CDS YP_764030.1 115315307 4307344 1603062..1603553 1 NC_008369.1 disulfide bond formation protein 1603553 dsbB 4307344 dsbB Francisella tularensis subsp. holarctica OSU18 disulfide bond formation protein YP_764030.1 1603062 D 393011 CDS YP_764031.1 115315308 4307345 1603566..1604939 1 NC_008369.1 RND efflux transporter 1604939 4307345 FTH_1612 Francisella tularensis subsp. holarctica OSU18 RND efflux transporter YP_764031.1 1603566 D 393011 CDS YP_764032.1 115315309 4307346 1604939..1608052 1 NC_008369.1 resistance-nodulation-cell division acriflavin:proton (H+) antiporter 1608052 4307346 FTH_1613 Francisella tularensis subsp. holarctica OSU18 resistance-nodulation-cell division acriflavin:proton (H+) antiporter YP_764032.1 1604939 D 393011 CDS YP_764033.1 115315310 4307347 1608184..1609464 1 NC_008369.1 major facilitator transporter 1609464 4307347 FTH_1614 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_764033.1 1608184 D 393011 CDS YP_764034.1 115315311 4307348 1609709..1610290 1 NC_008369.1 hypothetical protein 1610290 4307348 FTH_1615 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764034.1 1609709 D 393011 CDS YP_764035.1 115315312 4307350 complement(1611736..1612749) 1 NC_008369.1 possible microcin C7 resistance protein; hypothetical protein 1612749 4307350 FTH_1617 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764035.1 1611736 R 393011 CDS YP_764036.1 115315313 4307353 join(1614317..1614646,1614646..1615197) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1615197 isftu1 4307353 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_764036.1 1614317 D 393011 CDS YP_764037.1 115315314 4307354 1615249..1615500 1 NC_008369.1 hypothetical protein 1615500 4307354 FTH_1621 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764037.1 1615249 D 393011 CDS YP_764038.1 115315315 4307355 1615568..1616962 1 NC_008369.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1616962 cysS 4307355 cysS Francisella tularensis subsp. holarctica OSU18 cysteinyl-tRNA synthetase YP_764038.1 1615568 D 393011 CDS YP_764039.1 115315316 4307356 1616966..1617910 1 NC_008369.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1617910 hemK 4307356 hemK Francisella tularensis subsp. holarctica OSU18 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_764039.1 1616966 D 393011 CDS YP_764040.1 115315317 4307357 1617966..1619153 1 NC_008369.1 major facilitator transporter 1619153 4307357 FTH_1624 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_764040.1 1617966 D 393011 CDS YP_764041.1 115315318 4307358 1619167..1619658 1 NC_008369.1 acetyltransferase 1619658 4307358 FTH_1625 Francisella tularensis subsp. holarctica OSU18 acetyltransferase YP_764041.1 1619167 D 393011 CDS YP_764042.1 115315319 4307359 join(1619804..1620133,1620133..1620684) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1620684 isftu1 4307359 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_764042.1 1619804 D 393011 CDS YP_764043.1 115315320 4307360 complement(1620997..1621848) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1621848 4307360 FTH_1627 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764043.1 1620997 R 393011 CDS YP_764044.1 115315321 4307361 complement(1621852..1622781) 1 NC_008369.1 hypothetical protein 1622781 4307361 FTH_1628 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764044.1 1621852 R 393011 CDS YP_764045.1 115315322 4307362 complement(1622800..1623036) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1623036 4307362 FTH_1629 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764045.1 1622800 R 393011 CDS YP_764046.1 115315323 4307363 complement(1623187..1623507) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1623507 4307363 FTH_1630 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764046.1 1623187 R 393011 CDS YP_764047.1 115315324 4307364 complement(1623620..1624093) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1624093 4307364 FTH_1631 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764047.1 1623620 R 393011 CDS YP_764048.1 115315325 4307365 complement(1624301..1625491) 1 NC_008369.1 hypothetical protein 1625491 4307365 FTH_1632 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764048.1 1624301 R 393011 CDS YP_764049.1 115315326 4307366 complement(1625488..1626291) 1 NC_008369.1 hypothetical protein 1626291 4307366 FTH_1633 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764049.1 1625488 R 393011 CDS YP_764050.1 115315327 4307367 complement(1626275..1626622) 1 NC_008369.1 hypothetical protein 1626622 4307367 FTH_1634 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764050.1 1626275 R 393011 CDS YP_764051.1 115315328 4307369 complement(1628006..1629685) 1 NC_008369.1 glycosyltransferase 1629685 4307369 FTH_1636 Francisella tularensis subsp. holarctica OSU18 glycosyltransferase YP_764051.1 1628006 R 393011 CDS YP_764052.1 115315329 4307370 complement(1629756..1631222) 1 NC_008369.1 SSS family solute/sodium (Na+) symporter 1631222 putP 4307370 putP Francisella tularensis subsp. holarctica OSU18 SSS family solute/sodium (Na+) symporter YP_764052.1 1629756 R 393011 CDS YP_764053.1 115315330 4307371 complement(1631529..1632515) 1 NC_008369.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 1632515 glpX 4307371 glpX Francisella tularensis subsp. holarctica OSU18 fructose 1,6-bisphosphatase II YP_764053.1 1631529 R 393011 CDS YP_764054.1 115315331 4307372 complement(1632535..1633173) 1 NC_008369.1 alpha/beta fold family hydrolase 1633173 4307372 FTH_1639 Francisella tularensis subsp. holarctica OSU18 alpha/beta fold family hydrolase YP_764054.1 1632535 R 393011 CDS YP_764055.1 115315332 4307373 complement(1633182..1634636) 1 NC_008369.1 amino acid APC transporter 1634636 4307373 FTH_1640 Francisella tularensis subsp. holarctica OSU18 amino acid APC transporter YP_764055.1 1633182 R 393011 CDS YP_764056.1 115315333 4307374 complement(1634883..1635551) 1 NC_008369.1 hypothetical protein 1635551 4307374 FTH_1641 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764056.1 1634883 R 393011 CDS YP_764057.1 115315334 4307375 1635673..1638174 1 NC_008369.1 cell division protein 1638174 ftsK 4307375 ftsK Francisella tularensis subsp. holarctica OSU18 cell division protein YP_764057.1 1635673 D 393011 CDS YP_764058.1 115315335 4307376 1638175..1638792 1 NC_008369.1 lipoprotein releasing system subunit A, outer membrane lipoproteins carrier 1638792 lolA 4307376 lolA Francisella tularensis subsp. holarctica OSU18 lipoprotein releasing system subunit A, outer membrane lipoproteins carrier YP_764058.1 1638175 D 393011 CDS YP_764059.1 115315336 4307377 complement(1639186..1639389) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1639389 4307377 FTH_1644 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764059.1 1639186 R 393011 CDS YP_764060.1 115315337 4307378 1639501..1640955 1 NC_008369.1 Trk family K+ transporter membrane protein 1640955 trkH 4307378 trkH Francisella tularensis subsp. holarctica OSU18 Trk family K+ transporter membrane protein YP_764060.1 1639501 D 393011 CDS YP_764061.1 115315338 4307379 complement(1640970..1641515) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1641515 4307379 FTH_1646 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764061.1 1640970 R 393011 CDS YP_764062.1 115315339 4307381 complement(1642259..1642408) 1 NC_008369.1 hypothetical protein 1642408 4307381 FTH_1648 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764062.1 1642259 R 393011 CDS YP_764063.1 115315340 4307384 join(1643918..1644247,1644247..1644798) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1644798 isftu1 4307384 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_764063.1 1643918 D 393011 CDS YP_764064.1 115315341 4307385 complement(1644918..1646552) 1 NC_008369.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 1646552 groEL 4307385 groEL Francisella tularensis subsp. holarctica OSU18 chaperonin GroEL YP_764064.1 1644918 R 393011 CDS YP_764065.1 115315342 4307386 complement(1646590..1646877) 1 NC_008369.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1646877 groES 4307386 groES Francisella tularensis subsp. holarctica OSU18 co-chaperonin GroES YP_764065.1 1646590 R 393011 CDS YP_764066.1 115315343 4307387 complement(1647047..1647187) 1 NC_008369.1 hypothetical protein 1647187 4307387 FTH_1653 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764066.1 1647047 R 393011 CDS YP_764067.1 115315344 4307388 1647210..1647554 1 NC_008369.1 hypothetical protein 1647554 4307388 FTH_1654 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764067.1 1647210 D 393011 CDS YP_764068.1 115315345 4307390 complement(1647647..1647778) 1 NC_008369.1 hypothetical protein 1647778 4307390 FTH_1655 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764068.1 1647647 R 393011 CDS YP_764069.1 115315346 4307391 1648165..1648959 1 NC_008369.1 hypothetical protein 1648959 4307391 FTH_1656 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764069.1 1648165 D 393011 CDS YP_764070.1 115315347 4307392 complement(join(1649010..1649561,1649561..1649890)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1649890 isftu1 4307392 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_764070.1 1649010 R 393011 CDS YP_764071.1 115315348 4307393 1649881..1650381 1 NC_008369.1 hypothetical protein 1650381 4307393 FTH_1658 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764071.1 1649881 D 393011 CDS YP_764072.1 115315349 4307394 complement(1650372..1651226) 1 NC_008369.1 hemK methylase 1651226 4307394 FTH_1659 Francisella tularensis subsp. holarctica OSU18 hemK methylase YP_764072.1 1650372 R 393011 CDS YP_764073.1 115315350 4307395 complement(1651219..1652304) 1 NC_008369.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1652304 prfA 4307395 prfA Francisella tularensis subsp. holarctica OSU18 peptide chain release factor 1 YP_764073.1 1651219 R 393011 CDS YP_764074.1 115315351 4307396 complement(1652305..1653555) 1 NC_008369.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1653555 hemA 4307396 hemA Francisella tularensis subsp. holarctica OSU18 glutamyl-tRNA reductase YP_764074.1 1652305 R 393011 CDS YP_764075.1 115315352 4307397 1653729..1654367 1 NC_008369.1 hypothetical protein 1654367 4307397 FTH_1662 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764075.1 1653729 D 393011 CDS YP_764076.1 115315353 4307398 1654370..1655740 1 NC_008369.1 hypothetical protein 1655740 4307398 FTH_1663 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764076.1 1654370 D 393011 CDS YP_764077.1 115315354 4307399 1655740..1656921 1 NC_008369.1 major facilitator transporter 1656921 4307399 FTH_1664 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_764077.1 1655740 D 393011 CDS YP_764078.1 115315355 4307400 1657011..1658894 1 NC_008369.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 1658894 parE 4307400 parE Francisella tularensis subsp. holarctica OSU18 DNA topoisomerase IV subunit B YP_764078.1 1657011 D 393011 CDS YP_764079.1 115315356 4307401 complement(1658942..1659466) 1 NC_008369.1 N-acetyl-anhydromuranmyl-L-alanine amidase 1659466 ampD 4307401 ampD Francisella tularensis subsp. holarctica OSU18 N-acetyl-anhydromuranmyl-L-alanine amidase YP_764079.1 1658942 R 393011 CDS YP_764080.1 115315357 4307402 1659540..1660166 1 NC_008369.1 PAP2 family protein 1660166 4307402 FTH_1667 Francisella tularensis subsp. holarctica OSU18 PAP2 family protein YP_764080.1 1659540 D 393011 CDS YP_764081.1 115315358 4307403 complement(1660176..1660643) 1 NC_008369.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 1660643 4307403 FTH_1668 Francisella tularensis subsp. holarctica OSU18 dinucleoside polyphosphate hydrolase YP_764081.1 1660176 R 393011 CDS YP_764082.1 115315359 4307404 1660806..1662329 1 NC_008369.1 hypothetical protein 1662329 4307404 FTH_1669 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764082.1 1660806 D 393011 CDS YP_764083.1 115315360 4307405 1662447..1663331 1 NC_008369.1 licB-like transmembrane protein 1663331 4307405 FTH_1670 Francisella tularensis subsp. holarctica OSU18 licB-like transmembrane protein YP_764083.1 1662447 D 393011 CDS YP_764084.1 115315361 4307406 complement(1663328..1663912) 1 NC_008369.1 acid phosphomonoesterase; acid phosphatase 1663912 4307406 FTH_1671 Francisella tularensis subsp. holarctica OSU18 acid phosphatase YP_764084.1 1663328 R 393011 CDS YP_764085.1 115315362 4307407 complement(1663917..1664768) 1 NC_008369.1 oxidoreductase 1664768 4307407 FTH_1672 Francisella tularensis subsp. holarctica OSU18 oxidoreductase YP_764085.1 1663917 R 393011 CDS YP_764086.1 115315363 4307408 complement(1664885..1665763) 1 NC_008369.1 site specific recombinase XerD 1665763 xerD 4307408 xerD Francisella tularensis subsp. holarctica OSU18 site specific recombinase XerD YP_764086.1 1664885 R 393011 CDS YP_764087.1 115315364 4307409 complement(1665929..1666276) 1 NC_008369.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1666276 rplS 4307409 rplS Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L19 YP_764087.1 1665929 R 393011 CDS YP_764088.1 115315365 4307410 complement(1666276..1667040) 1 NC_008369.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 1667040 trmD 4307410 trmD Francisella tularensis subsp. holarctica OSU18 tRNA (guanine-N(1)-)-methyltransferase YP_764088.1 1666276 R 393011 CDS YP_764089.1 115315366 4307411 complement(1667437..1667946) 1 NC_008369.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 1667946 rimM 4307411 rimM Francisella tularensis subsp. holarctica OSU18 16S rRNA-processing protein RimM YP_764089.1 1667437 R 393011 CDS YP_764090.1 115315367 4307412 complement(1667989..1668237) 1 NC_008369.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 1668237 rpsP 4307412 rpsP Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S16 YP_764090.1 1667989 R 393011 CDS YP_764091.1 115315368 4307413 1668530..1669690 1 NC_008369.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1669690 metK 4307413 metK Francisella tularensis subsp. holarctica OSU18 S-adenosylmethionine synthetase YP_764091.1 1668530 D 393011 CDS YP_764092.1 115315369 4307414 complement(1669902..1671068) 1 NC_008369.1 fatty acid desaturase 1671068 4307414 FTH_1679 Francisella tularensis subsp. holarctica OSU18 fatty acid desaturase YP_764092.1 1669902 R 393011 CDS YP_764093.1 115315370 4307415 complement(1671182..1672192) 1 NC_008369.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 1672192 gcp 4307415 gcp Francisella tularensis subsp. holarctica OSU18 putative DNA-binding/iron metalloprotein/AP endonuclease YP_764093.1 1671182 R 393011 CDS YP_764094.1 115315371 4307416 complement(1672192..1672428) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1672428 4307416 FTH_1681 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764094.1 1672192 R 393011 CDS YP_764095.1 115315372 4307417 complement(1672531..1676784) 1 NC_008369.1 DNA-dependent RNA polymerase; DNA-directed RNA polymerase 1676784 rpoC 4307417 rpoC Francisella tularensis subsp. holarctica OSU18 DNA-directed RNA polymerase YP_764095.1 1672531 R 393011 CDS YP_764096.1 115315373 4307418 complement(1676846..1680922) 1 NC_008369.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1680922 rpoB 4307418 rpoB Francisella tularensis subsp. holarctica OSU18 DNA-directed RNA polymerase subunit beta YP_764096.1 1676846 R 393011 CDS YP_764097.1 115315374 4307419 complement(1680946..1681044) 1 NC_008369.1 hypothetical protein 1681044 4307419 FTH_1684 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764097.1 1680946 R 393011 CDS YP_764098.1 115315375 4307420 complement(1681076..1681453) 1 NC_008369.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1681453 rplL 4307420 rplL Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L7/L12 YP_764098.1 1681076 R 393011 CDS YP_764099.1 115315376 4307421 complement(1681515..1682033) 1 NC_008369.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1682033 rplJ 4307421 rplJ Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L10 YP_764099.1 1681515 R 393011 CDS YP_764100.2 394894296 4307422 complement(1682203..1682898) 1 NC_008369.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 1682898 rplA 4307422 rplA Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L1 YP_764100.2 1682203 R 393011 CDS YP_764101.1 115315378 4307423 complement(1682901..1683335) 1 NC_008369.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 1683335 rplK 4307423 rplK Francisella tularensis subsp. holarctica OSU18 50S ribosomal protein L11 YP_764101.1 1682901 R 393011 CDS YP_764102.1 115315379 4307424 complement(1683404..1683937) 1 NC_008369.1 transcription antitermination protein NusG 1683937 nusG 4307424 nusG Francisella tularensis subsp. holarctica OSU18 transcription antitermination protein NusG YP_764102.1 1683404 R 393011 CDS YP_764103.1 115315380 4307427 complement(1684613..1685797) 1 NC_008369.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1685797 tufA 4307427 tufA Francisella tularensis subsp. holarctica OSU18 elongation factor Tu YP_764103.1 1684613 R 393011 CDS YP_764104.1 115315381 4307432 complement(1687676..1688173) 1 NC_008369.1 MscS family small conductance mechanosenstive ion channel protein 1688173 4307432 FTH_1693 Francisella tularensis subsp. holarctica OSU18 MscS family small conductance mechanosenstive ion channel protein YP_764104.1 1687676 R 393011 CDS YP_764105.1 115315382 4307433 complement(1688151..1688864) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1688864 4307433 FTH_1694 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764105.1 1688151 R 393011 CDS YP_764106.1 115315383 4307434 complement(1688868..1689632) 1 NC_008369.1 glycerol uptake facilitator protein 1689632 glpF 4307434 glpF Francisella tularensis subsp. holarctica OSU18 glycerol uptake facilitator protein YP_764106.1 1688868 R 393011 CDS YP_764107.1 115315384 4307435 complement(1689642..1691174) 1 NC_008369.1 glycerol-3-phosphate dehydrogenase 1691174 glpA 4307435 glpA Francisella tularensis subsp. holarctica OSU18 glycerol-3-phosphate dehydrogenase YP_764107.1 1689642 R 393011 CDS YP_764108.1 115315385 4307438 complement(1693021..1694301) 1 NC_008369.1 hypothetical protein 1694301 4307438 FTH_1699 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764108.1 1693021 R 393011 CDS YP_764109.1 115315386 4307440 1695374..1696801 1 NC_008369.1 sensor kinase 1696801 qseC 4307440 qseC Francisella tularensis subsp. holarctica OSU18 sensor kinase YP_764109.1 1695374 D 393011 CDS YP_764110.1 115315387 4307441 complement(1696798..1697679) 1 NC_008369.1 hypothetical protein 1697679 4307441 FTH_1702 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764110.1 1696798 R 393011 CDS YP_764111.1 115315388 4307443 1699281..1700243 1 NC_008369.1 cytochrome d ubiquinol oxidase subunit II 1700243 4307443 FTH_1704 Francisella tularensis subsp. holarctica OSU18 cytochrome d ubiquinol oxidase subunit II YP_764111.1 1699281 D 393011 CDS YP_764112.1 115315389 4307444 1700254..1700688 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1700688 4307444 FTH_1705 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764112.1 1700254 D 393011 CDS YP_764113.1 115315390 4307447 complement(1702885..1705698) 1 NC_008369.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1705698 acnA 4307447 acnA Francisella tularensis subsp. holarctica OSU18 aconitate hydratase YP_764113.1 1702885 R 393011 CDS YP_764114.1 115315391 4307448 complement(1705803..1706681) 1 NC_008369.1 hypothetical protein 1706681 4307448 FTH_1709 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764114.1 1705803 R 393011 CDS YP_764115.1 115315392 4307449 1706751..1707128 1 NC_008369.1 hypothetical protein 1707128 4307449 FTH_1710 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764115.1 1706751 D 393011 CDS YP_764116.1 115315393 4307450 1707133..1708275 1 NC_008369.1 coprogen oxidase; coproporphyrinogen oxidase 1708275 hemN 4307450 hemN Francisella tularensis subsp. holarctica OSU18 coproporphyrinogen oxidase YP_764116.1 1707133 D 393011 CDS YP_764117.1 115315394 4307451 complement(1708272..1708748) 1 NC_008369.1 hypothetical protein 1708748 4307451 FTH_1712 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764117.1 1708272 R 393011 CDS YP_764118.1 115315395 4307452 complement(1708831..1709193) 1 NC_008369.1 hypothetical protein 1709193 4307452 FTH_1713 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764118.1 1708831 R 393011 CDS YP_764119.1 115315396 4307453 complement(1709171..1709785) 1 NC_008369.1 LysR family transcriptional regulator 1709785 4307453 FTH_1714 Francisella tularensis subsp. holarctica OSU18 LysR family transcriptional regulator YP_764119.1 1709171 R 393011 CDS YP_764120.1 115315397 4307455 complement(1709954..1710307) 1 NC_008369.1 preprotein translocase subunit SecG 1710307 secG 4307455 secG Francisella tularensis subsp. holarctica OSU18 preprotein translocase subunit SecG YP_764120.1 1709954 R 393011 CDS YP_764121.1 115315398 4307456 complement(1710295..1711056) 1 NC_008369.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1711056 tpiA 4307456 tpiA Francisella tularensis subsp. holarctica OSU18 triosephosphate isomerase YP_764121.1 1710295 R 393011 CDS YP_764122.1 115315399 4307457 complement(1711059..1712390) 1 NC_008369.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1712390 glmM 4307457 glmM Francisella tularensis subsp. holarctica OSU18 phosphoglucosamine mutase YP_764122.1 1711059 R 393011 CDS YP_764123.1 115315400 4307458 complement(1712401..1712928) 1 NC_008369.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1712928 apt 4307458 apt Francisella tularensis subsp. holarctica OSU18 adenine phosphoribosyltransferase YP_764123.1 1712401 R 393011 CDS YP_764124.1 115315401 4307459 complement(1712968..1714437) 1 NC_008369.1 dihydrolipoamide S-succinyltransferase; dihydrolipoyllysine-residue succinyltransferase 1714437 sucB 4307459 sucB Francisella tularensis subsp. holarctica OSU18 dihydrolipoyllysine-residue succinyltransferase YP_764124.1 1712968 R 393011 CDS YP_764125.1 115315402 4307460 complement(1714463..1717276) 1 NC_008369.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 1717276 sucA 4307460 sucA Francisella tularensis subsp. holarctica OSU18 2-oxoglutarate dehydrogenase E1 component YP_764125.1 1714463 R 393011 CDS YP_764126.1 115315403 4307461 complement(1717306..1718007) 1 NC_008369.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 1718007 sdhB 4307461 sdhB Francisella tularensis subsp. holarctica OSU18 succinate dehydrogenase iron-sulfur subunit YP_764126.1 1717306 R 393011 CDS YP_764127.1 115315404 4307462 complement(1718025..1719818) 1 NC_008369.1 fumarate dehydrogenase; succinate dehydrogenase 1719818 sdhA 4307462 sdhA Francisella tularensis subsp. holarctica OSU18 succinate dehydrogenase YP_764127.1 1718025 R 393011 CDS YP_764128.1 115315405 4307463 complement(1719831..1720199) 1 NC_008369.1 fumarate dehydrogenase; succinate dehydrogenase 1720199 sdhD 4307463 sdhD Francisella tularensis subsp. holarctica OSU18 succinate dehydrogenase YP_764128.1 1719831 R 393011 CDS YP_764129.1 115315406 4307464 complement(1720175..1720648) 1 NC_008369.1 fumarate dehydrogenase; succinate dehydrogenase 1720648 sdhC 4307464 sdhC Francisella tularensis subsp. holarctica OSU18 succinate dehydrogenase YP_764129.1 1720175 R 393011 CDS YP_764130.1 115315407 4307465 1720891..1722165 1 NC_008369.1 (R)-citric synthase; citrate (Si)-synthase 1722165 gltA 4307465 gltA Francisella tularensis subsp. holarctica OSU18 citrate (Si)-synthase YP_764130.1 1720891 D 393011 CDS YP_764131.1 115315408 4307466 1722254..1723519 1 NC_008369.1 AmpG-signal transducer; major facilitator transporter 1723519 ampG 4307466 ampG Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_764131.1 1722254 D 393011 CDS YP_764132.1 115315409 4307467 1723531..1723716 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1723716 4307467 FTH_1727 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764132.1 1723531 D 393011 CDS YP_764133.1 115315410 4307468 complement(1723724..1724302) 1 NC_008369.1 superoxide dismutase 1724302 sodB 4307468 sodB Francisella tularensis subsp. holarctica OSU18 superoxide dismutase YP_764133.1 1723724 R 393011 CDS YP_764134.1 115315411 4307469 1724438..1724767 1 NC_008369.1 glutaredoxin-like protein 1724767 4307469 FTH_1729 Francisella tularensis subsp. holarctica OSU18 glutaredoxin-like protein YP_764134.1 1724438 D 393011 CDS YP_764135.1 115315412 4307470 complement(1724784..1727627) 1 NC_008369.1 hypothetical protein 1727627 4307470 FTH_1730 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764135.1 1724784 R 393011 CDS YP_764136.1 115315413 4307471 complement(1727838..1728275) 1 NC_008369.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit epsilon 1728275 atpC 4307471 atpC Francisella tularensis subsp. holarctica OSU18 F0F1 ATP synthase subunit epsilon YP_764136.1 1727838 R 393011 CDS YP_764137.1 115315414 4307472 complement(1728288..1729664) 1 NC_008369.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 1729664 atpD 4307472 atpD Francisella tularensis subsp. holarctica OSU18 F0F1 ATP synthase subunit beta YP_764137.1 1728288 R 393011 CDS YP_764138.1 115315415 4307473 complement(1729674..1730570) 1 NC_008369.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 1730570 atpG 4307473 atpG Francisella tularensis subsp. holarctica OSU18 F0F1 ATP synthase subunit gamma YP_764138.1 1729674 R 393011 CDS YP_764139.1 115315416 4307474 complement(1730585..1732126) 1 NC_008369.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 1732126 atpA 4307474 atpA Francisella tularensis subsp. holarctica OSU18 F0F1 ATP synthase subunit alpha YP_764139.1 1730585 R 393011 CDS YP_764140.1 115315417 4307475 complement(1732145..1732669) 1 NC_008369.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 1732669 atpH 4307475 atpH Francisella tularensis subsp. holarctica OSU18 F0F1 ATP synthase subunit delta YP_764140.1 1732145 R 393011 CDS YP_764141.1 115315418 4307476 complement(1732689..1733159) 1 NC_008369.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 1733159 atpF 4307476 atpF Francisella tularensis subsp. holarctica OSU18 F0F1 ATP synthase subunit B YP_764141.1 1732689 R 393011 CDS YP_764142.1 115315419 4307477 complement(1733205..1733510) 1 NC_008369.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 1733510 atpE 4307477 atpE Francisella tularensis subsp. holarctica OSU18 F0F1 ATP synthase subunit C YP_764142.1 1733205 R 393011 CDS YP_764143.1 115315420 4307478 complement(1733561..1734352) 1 NC_008369.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 1734352 atpB 4307478 atpB Francisella tularensis subsp. holarctica OSU18 F0F1 ATP synthase subunit A YP_764143.1 1733561 R 393011 CDS YP_764144.1 115315421 4307479 complement(1734405..1734836) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1734836 4307479 FTH_1739 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764144.1 1734405 R 393011 CDS YP_764145.1 115315422 4307480 1734913..1736217 1 NC_008369.1 major facilitator transporter 1736217 4307480 FTH_1740 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_764145.1 1734913 D 393011 CDS YP_764146.1 115315423 4307481 complement(1736219..1737148) 1 NC_008369.1 pseudouridine synthase; ribosomal large subunit pseudouridine synthase C 1737148 rluC 4307481 rluC Francisella tularensis subsp. holarctica OSU18 ribosomal large subunit pseudouridine synthase C YP_764146.1 1736219 R 393011 CDS YP_764147.1 115315424 4307482 complement(1737141..1738208) 1 NC_008369.1 ATPase 1738208 4307482 FTH_1742 Francisella tularensis subsp. holarctica OSU18 ATPase YP_764147.1 1737141 R 393011 CDS YP_764148.1 115315425 4307483 complement(1738211..1739509) 1 NC_008369.1 major facilitator transporter 1739509 4307483 FTH_1743 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_764148.1 1738211 R 393011 CDS YP_764149.1 115315426 4307484 complement(1739516..1740781) 1 NC_008369.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 1740781 hisS 4307484 hisS Francisella tularensis subsp. holarctica OSU18 histidyl-tRNA synthetase YP_764149.1 1739516 R 393011 CDS YP_764150.1 115315427 4307485 complement(1740789..1741220) 1 NC_008369.1 ribosome-binding factor A 1741220 rbfA 4307485 rbfA Francisella tularensis subsp. holarctica OSU18 ribosome-binding factor A YP_764150.1 1740789 R 393011 CDS YP_764151.1 115315428 4307486 complement(1741223..1743763) 1 NC_008369.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1743763 infB 4307486 infB Francisella tularensis subsp. holarctica OSU18 translation initiation factor IF-2 YP_764151.1 1741223 R 393011 CDS YP_764152.1 115315429 4307487 complement(1743802..1745271) 1 NC_008369.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 1745271 nusA 4307487 nusA Francisella tularensis subsp. holarctica OSU18 transcription elongation factor NusA YP_764152.1 1743802 R 393011 CDS YP_764153.1 115315430 4307488 complement(1745289..1745747) 1 NC_008369.1 hypothetical protein 1745747 4307488 FTH_1748 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764153.1 1745289 R 393011 CDS YP_764154.1 115315431 4307490 complement(1745967..1747001) 1 NC_008369.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 1747001 hemE 4307490 hemE Francisella tularensis subsp. holarctica OSU18 uroporphyrinogen decarboxylase YP_764154.1 1745967 R 393011 CDS YP_764155.1 115315432 4307492 complement(join(1748493..1749044,1749044..1749373)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1749373 isftu1 4307492 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_764155.1 1748493 R 393011 CDS YP_764156.1 115315433 4307493 complement(1749514..1749708) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1749708 4307493 FTH_1752 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764156.1 1749514 R 393011 CDS YP_764157.1 115315434 4307494 complement(1749784..1751241) 1 NC_008369.1 coenzyme Q reductase; NADH dehydrogenase (ubiquinone) 1751241 nuoN 4307494 nuoN Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase (ubiquinone) YP_764157.1 1749784 R 393011 CDS YP_764158.1 115315435 4307495 complement(1751251..1752840) 1 NC_008369.1 coenzyme Q reductase; NADH dehydrogenase I subunit M 1752840 nuoM 4307495 nuoM Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase I subunit M YP_764158.1 1751251 R 393011 CDS YP_764159.1 115315436 4307496 complement(1752866..1754875) 1 NC_008369.1 coenzyme Q reductase; NADH dehydrogenase I subunit L 1754875 nuoL 4307496 nuoL Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase I subunit L YP_764159.1 1752866 R 393011 CDS YP_764160.1 115315437 4307497 complement(1754885..1755217) 1 NC_008369.1 coenzyme Q reductase; NADH dehydrogenase (ubiquinone) 1755217 nuoK 4307497 nuoK Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase (ubiquinone) YP_764160.1 1754885 R 393011 CDS YP_764161.1 115315438 4307498 complement(1755195..1755800) 1 NC_008369.1 coenzyme Q reductase; NADH dehydrogenase I subunit J 1755800 nuoJ 4307498 nuoJ Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase I subunit J YP_764161.1 1755195 R 393011 CDS YP_764162.1 115315439 4307499 complement(1755805..1756293) 1 NC_008369.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 1756293 nuoI 4307499 nuoI Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase subunit I YP_764162.1 1755805 R 393011 CDS YP_764163.1 115315440 4307500 complement(1756307..1757317) 1 NC_008369.1 coenzyme Q reductase; NADH dehydrogenase I subunit H 1757317 nuoH 4307500 nuoH Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase I subunit H YP_764163.1 1756307 R 393011 CDS YP_764164.1 115315441 4307501 complement(1757319..1759685) 1 NC_008369.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit G 1759685 nuoG 4307501 nuoG Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase subunit G YP_764164.1 1757319 R 393011 CDS YP_764165.1 115315442 4307502 complement(1759703..1760977) 1 NC_008369.1 coenzyme Q reductase; NADH dehydrogenase (ubiquinone) 1760977 nuoF 4307502 nuoF Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase (ubiquinone) YP_764165.1 1759703 R 393011 CDS YP_764166.1 115315443 4307503 complement(1760984..1761472) 1 NC_008369.1 coenzyme Q reductase; NADH dehydrogenase I subunit E 1761472 nuoE 4307503 nuoE Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase I subunit E YP_764166.1 1760984 R 393011 CDS YP_764167.1 115315444 4307504 complement(1761482..1762735) 1 NC_008369.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 1762735 nuoD 4307504 nuoD Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase subunit D YP_764167.1 1761482 R 393011 CDS YP_764168.1 115315445 4307505 complement(1762757..1763407) 1 NC_008369.1 coenzyme Q reductase; NADH dehydrogenase (ubiquinone) 1763407 nuoC 4307505 nuoC Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase (ubiquinone) YP_764168.1 1762757 R 393011 CDS YP_764169.1 115315446 4307506 complement(1763404..1763880) 1 NC_008369.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 1763880 nuoB 4307506 nuoB Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase subunit B YP_764169.1 1763404 R 393011 CDS YP_764170.1 115315447 4307507 complement(1763871..1764269) 1 NC_008369.1 NADH dehydrogenase I subunit A 1764269 nuoA 4307507 nuoA Francisella tularensis subsp. holarctica OSU18 NADH dehydrogenase I subunit A YP_764170.1 1763871 R 393011 CDS YP_764171.1 115315448 4307508 1764478..1764900 1 NC_008369.1 ferric uptake regulation protein 1764900 fur2 4307508 fur2 Francisella tularensis subsp. holarctica OSU18 ferric uptake regulation protein YP_764171.1 1764478 D 393011 CDS YP_764172.1 115315449 4307509 1765154..1767073 1 NC_008369.1 siderophore biosynthesis IucA / IucC family protein 1767073 iucA/iucC 4307509 iucA/iucC Francisella tularensis subsp. holarctica OSU18 siderophore biosynthesis IucA / IucC family protein YP_764172.1 1765154 D 393011 CDS YP_764173.1 115315450 4307510 1767080..1768342 1 NC_008369.1 major facilitator superfamily multidrug resistance protein 1768342 4307510 FTH_1769 Francisella tularensis subsp. holarctica OSU18 major facilitator superfamily multidrug resistance protein YP_764173.1 1767080 D 393011 CDS YP_764174.1 115315451 4307511 1768335..1769588 1 NC_008369.1 DAP decarboxylase; diaminopimelate decarboxylase 1769588 lysA2 4307511 lysA2 Francisella tularensis subsp. holarctica OSU18 diaminopimelate decarboxylase YP_764174.1 1768335 D 393011 CDS YP_764175.1 115315452 4307512 1769604..1770794 1 NC_008369.1 major facilitator transporter 1770794 4307512 FTH_1771 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_764175.1 1769604 D 393011 CDS YP_764176.1 115315453 4307513 1770880..1772409 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1772409 4307513 FTH_1772 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764176.1 1770880 D 393011 CDS YP_764177.1 115315454 4307514 1772457..1772819 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1772819 4307514 FTH_1773 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764177.1 1772457 D 393011 CDS YP_764178.1 115315455 4306373 1773068..1773949 1 NC_008369.1 phospholipase/acyltransferase 1773949 4306373 FTH_1774 Francisella tularensis subsp. holarctica OSU18 phospholipase/acyltransferase YP_764178.1 1773068 D 393011 CDS YP_764179.1 115315456 4306374 complement(1773965..1774372) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1774372 4306374 FTH_1775 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764179.1 1773965 R 393011 CDS YP_764180.1 115315457 4306375 complement(1774387..1775808) 1 NC_008369.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 1775808 gatB 4306375 gatB Francisella tularensis subsp. holarctica OSU18 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_764180.1 1774387 R 393011 CDS YP_764181.1 115315458 4306376 complement(1775811..1777256) 1 NC_008369.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 1777256 gatA 4306376 gatA Francisella tularensis subsp. holarctica OSU18 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_764181.1 1775811 R 393011 CDS YP_764182.1 115315459 4306377 complement(1777265..1777546) 1 NC_008369.1 Glu-tRNAGln amidotransferase C subunit 1777546 gatC 4306377 gatC Francisella tularensis subsp. holarctica OSU18 Glu-tRNAGln amidotransferase C subunit YP_764182.1 1777265 R 393011 CDS YP_764183.1 115315460 4306380 complement(1780333..1780911) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1780911 4306380 FTH_1781 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764183.1 1780333 R 393011 CDS YP_764184.1 115315461 4306381 complement(1780945..1782243) 1 NC_008369.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1782243 purB 4306381 purB Francisella tularensis subsp. holarctica OSU18 adenylosuccinate lyase YP_764184.1 1780945 R 393011 CDS YP_764185.1 115315462 4306383 1783429..1783827 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1783827 4306383 FTH_1784 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764185.1 1783429 D 393011 CDS YP_764186.1 115315463 4306384 1784070..1784852 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1784852 4306384 FTH_1785 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764186.1 1784070 D 393011 CDS YP_764187.1 115315464 4306385 complement(1784870..1785730) 1 NC_008369.1 galactose mutarotase 1785730 4306385 FTH_1786 Francisella tularensis subsp. holarctica OSU18 galactose mutarotase YP_764187.1 1784870 R 393011 CDS YP_764188.1 115315465 4306388 complement(1787847..1791719) 1 NC_008369.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 1791719 purL 4306388 purL Francisella tularensis subsp. holarctica OSU18 phosphoribosylformylglycinamidine synthase YP_764188.1 1787847 R 393011 CDS YP_764189.1 115315466 4306389 complement(1791719..1793209) 1 NC_008369.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 1793209 purF 4306389 purF Francisella tularensis subsp. holarctica OSU18 amidophosphoribosyltransferase YP_764189.1 1791719 R 393011 CDS YP_764190.1 115315467 4306391 complement(1794619..1795263) 1 NC_008369.1 phosphopantetheinyl transferase 1795263 4306391 FTH_1792 Francisella tularensis subsp. holarctica OSU18 phosphopantetheinyl transferase YP_764190.1 1794619 R 393011 CDS YP_764191.1 115315468 4306392 complement(1795269..1796798) 1 NC_008369.1 outer membrane protein tolC 1796798 tolC 4306392 tolC Francisella tularensis subsp. holarctica OSU18 outer membrane protein tolC YP_764191.1 1795269 R 393011 CDS YP_764192.1 115315469 4306393 complement(1796807..1797427) 1 NC_008369.1 L-isoaspartyl protein carboxyl methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase 1797427 pcm 4306393 pcm Francisella tularensis subsp. holarctica OSU18 protein-L-isoaspartate(D-aspartate) O-methyltransferase YP_764192.1 1796807 R 393011 CDS YP_764193.1 115315470 4306394 1797747..1799078 1 NC_008369.1 hypothetical protein 1799078 yegQ 4306394 yegQ Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764193.1 1797747 D 393011 CDS YP_764194.1 115315471 4306395 complement(1799118..1800299) 1 NC_008369.1 major facilitator superfamily multidrug resistance protein 1800299 4306395 FTH_1796 Francisella tularensis subsp. holarctica OSU18 major facilitator superfamily multidrug resistance protein YP_764194.1 1799118 R 393011 CDS YP_764195.1 115315472 4306396 1800474..1801901 1 NC_008369.1 NhaD family Na(+)/H(+) antiporter 1801901 nhaD 4306396 nhaD Francisella tularensis subsp. holarctica OSU18 NhaD family Na(+)/H(+) antiporter YP_764195.1 1800474 D 393011 CDS YP_764196.1 115315473 4306398 complement(1803541..1805415) 1 NC_008369.1 APC family amino acid-polyamine-organocation transporter 1805415 4306398 FTH_1799 Francisella tularensis subsp. holarctica OSU18 APC family amino acid-polyamine-organocation transporter YP_764196.1 1803541 R 393011 CDS YP_764197.1 115315474 4306399 complement(1805422..1806426) 1 NC_008369.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1806426 obgE 4306399 obgE Francisella tularensis subsp. holarctica OSU18 GTPase ObgE YP_764197.1 1805422 R 393011 CDS YP_764198.1 115315475 4306400 complement(1806502..1807698) 1 NC_008369.1 HAAAP family tyrosine/H(+) symporter 1807698 4306400 FTH_1801 Francisella tularensis subsp. holarctica OSU18 HAAAP family tyrosine/H(+) symporter YP_764198.1 1806502 R 393011 CDS YP_764199.1 115315476 4306401 1807825..1808136 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1808136 4306401 FTH_1802 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764199.1 1807825 D 393011 CDS YP_764200.1 115315477 4306405 complement(1812499..1813053) 1 NC_008369.1 K(+)-importing ATPase; potassium-transporting ATPase 1813053 kdpC 4306405 kdpC Francisella tularensis subsp. holarctica OSU18 potassium-transporting ATPase YP_764200.1 1812499 R 393011 CDS YP_764201.1 115315478 4306590 complement(1815057..1816778) 1 NC_008369.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 1816778 kdpA 4306590 kdpA Francisella tularensis subsp. holarctica OSU18 potassium-transporting ATPase subunit A YP_764201.1 1815057 R 393011 CDS YP_764202.1 115315479 4306595 complement(1820331..1820900) 1 NC_008369.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 1820900 leuD 4306595 leuD Francisella tularensis subsp. holarctica OSU18 isopropylmalate isomerase small subunit YP_764202.1 1820331 R 393011 CDS YP_764203.1 115315480 4306596 complement(1820903..1822306) 1 NC_008369.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 1822306 4306596 FTH_1814 Francisella tularensis subsp. holarctica OSU18 isopropylmalate isomerase large subunit YP_764203.1 1820903 R 393011 CDS YP_764204.1 115315481 4306597 join(1822584..1822913,1822913..1823464) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1823464 isftu1 4306597 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_764204.1 1822584 D 393011 CDS YP_764205.1 115315482 4306598 complement(1823661..1824656) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1824656 4306598 FTH_1816 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764205.1 1823661 R 393011 CDS YP_764206.1 115315483 4306600 complement(1826061..1827458) 1 NC_008369.1 hypothetical protein 1827458 4306600 FTH_1818 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764206.1 1826061 R 393011 CDS YP_764207.1 115315484 4306601 complement(1827622..1828140) 1 NC_008369.1 outer membrane lipoprotein 1828140 blc 4306601 blc Francisella tularensis subsp. holarctica OSU18 outer membrane lipoprotein YP_764207.1 1827622 R 393011 CDS YP_764208.1 115315485 4306602 1828226..1829203 1 NC_008369.1 DNA nucleotidyltransferase (DNA-directed); DNA polymerase III subunit delta 1829203 holA 4306602 holA Francisella tularensis subsp. holarctica OSU18 DNA polymerase III subunit delta YP_764208.1 1828226 D 393011 CDS YP_764209.1 115315486 4306603 1829323..1830360 1 NC_008369.1 glutamine synthetase 1830360 glnA 4306603 glnA Francisella tularensis subsp. holarctica OSU18 glutamine synthetase YP_764209.1 1829323 D 393011 CDS YP_764210.1 115315487 4306604 1830442..1831983 1 NC_008369.1 L-glutamine amidohydrolase; glutaminase 1831983 glsA 4306604 glsA Francisella tularensis subsp. holarctica OSU18 glutaminase YP_764210.1 1830442 D 393011 CDS YP_764211.1 115315488 4306606 1832967..1833509 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1833509 4306606 FTH_1824 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764211.1 1832967 D 393011 CDS YP_764212.1 115315489 4306607 complement(1833894..1835624) 1 NC_008369.1 lysine translase; lysyl-tRNA synthetase 1835624 lysU 4306607 lysU Francisella tularensis subsp. holarctica OSU18 lysyl-tRNA synthetase YP_764212.1 1833894 R 393011 CDS YP_764213.1 115315490 4306608 complement(1835637..1835732) 1 NC_008369.1 hypothetical protein 1835732 4306608 FTH_1826 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764213.1 1835637 R 393011 CDS YP_764214.1 115315491 4306609 complement(1835754..1836731) 1 NC_008369.1 peptide chain release factor 2 1836731 prfB 4306609 prfB Francisella tularensis subsp. holarctica OSU18 peptide chain release factor 2 YP_764214.1 1835754 R 393011 CDS YP_764215.1 115315492 4306610 1837004..1838641 1 NC_008369.1 DNA nucleotidyltransferase (DNA-directed); DNA polymerase III subunit gamma and tau 1838641 dnaX 4306610 dnaX Francisella tularensis subsp. holarctica OSU18 DNA polymerase III subunit gamma and tau YP_764215.1 1837004 D 393011 CDS YP_764216.1 115315493 4306611 complement(1838655..1839515) 1 NC_008369.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 1839515 lpxC 4306611 lpxC Francisella tularensis subsp. holarctica OSU18 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_764216.1 1838655 R 393011 CDS YP_764217.1 115315494 4306612 complement(1839538..1840683) 1 NC_008369.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1840683 ftsZ 4306612 ftsZ Francisella tularensis subsp. holarctica OSU18 cell division protein FtsZ YP_764217.1 1839538 R 393011 CDS YP_764218.1 115315495 4306613 complement(1840727..1841989) 1 NC_008369.1 cell division protein FtsA 1841989 ftsA 4306613 ftsA Francisella tularensis subsp. holarctica OSU18 cell division protein FtsA YP_764218.1 1840727 R 393011 CDS YP_764219.1 115315496 4306614 complement(1842091..1842774) 1 NC_008369.1 cell division protein FtsQ 1842774 ftsQ 4306614 ftsQ Francisella tularensis subsp. holarctica OSU18 cell division protein FtsQ YP_764219.1 1842091 R 393011 CDS YP_764220.1 115315497 4306615 complement(1842771..1843661) 1 NC_008369.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 1843661 ddlB 4306615 ddlB Francisella tularensis subsp. holarctica OSU18 D-alanyl-alanine synthetase A YP_764220.1 1842771 R 393011 CDS YP_764221.1 115315498 4306616 complement(1843665..1844126) 1 NC_008369.1 cytosine/adenosine deaminase 1844126 4306616 FTH_1834 Francisella tularensis subsp. holarctica OSU18 cytosine/adenosine deaminase YP_764221.1 1843665 R 393011 CDS YP_764222.1 115315499 4306617 1844220..1845944 1 NC_008369.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1845944 rpsA 4306617 rpsA Francisella tularensis subsp. holarctica OSU18 30S ribosomal protein S1 YP_764222.1 1844220 D 393011 CDS YP_764223.1 115315500 4306618 1846061..1846603 1 NC_008369.1 Sua5/YciO/YrdC family protein 1846603 4306618 FTH_1836 Francisella tularensis subsp. holarctica OSU18 Sua5/YciO/YrdC family protein YP_764223.1 1846061 D 393011 CDS YP_764224.1 115315501 4306619 1846701..1847237 1 NC_008369.1 hypothetical protein 1847237 4306619 FTH_1837 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764224.1 1846701 D 393011 CDS YP_764225.1 115315502 4306620 complement(1847623..1848513) 1 NC_008369.1 putative acyltransferase 1848513 4306620 FTH_1838 Francisella tularensis subsp. holarctica OSU18 putative acyltransferase YP_764225.1 1847623 R 393011 CDS YP_764226.1 115315503 4306624 1854004..1854786 1 NC_008369.1 ABC transporter ATP-binding protein 1854786 4306624 FTH_1842 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_764226.1 1854004 D 393011 CDS YP_764227.1 115315504 4306625 complement(1854780..1855349) 1 NC_008369.1 hypothetical protein 1855349 4306625 FTH_1843 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764227.1 1854780 R 393011 CDS YP_764228.1 115315505 4306626 complement(1855442..1856272) 1 NC_008369.1 hypothetical protein 1856272 4306626 FTH_1844 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764228.1 1855442 R 393011 CDS YP_764229.1 115315506 4306627 complement(1856342..1856737) 1 NC_008369.1 hypothetical protein 1856737 4306627 FTH_1845 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764229.1 1856342 R 393011 CDS YP_764230.1 115315507 4306628 complement(join(1856697..1857248,1857248..1857577)) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1857577 isftu1 4306628 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_764230.1 1856697 R 393011 CDS YP_764231.1 115315508 4306631 complement(1859495..1861042) 1 NC_008369.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1861042 purH 4306631 purH Francisella tularensis subsp. holarctica OSU18 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_764231.1 1859495 R 393011 CDS YP_764232.1 115315509 4306632 1861219..1862505 1 NC_008369.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 1862505 purA 4306632 purA Francisella tularensis subsp. holarctica OSU18 adenylosuccinate synthetase YP_764232.1 1861219 D 393011 CDS YP_764233.1 115315510 4306633 1862509..1863042 1 NC_008369.1 guanine phosphoribosyltransferase; hypoxanthine phosphoribosyltransferase 1863042 hpt 4306633 hpt Francisella tularensis subsp. holarctica OSU18 hypoxanthine phosphoribosyltransferase YP_764233.1 1862509 D 393011 CDS YP_764234.1 115315511 4306635 complement(1863872..1864714) 1 NC_008369.1 cation ABC transporter ATP-binding protein 1864714 4306635 FTH_1853 Francisella tularensis subsp. holarctica OSU18 cation ABC transporter ATP-binding protein YP_764234.1 1863872 R 393011 CDS YP_764235.1 115315512 4306636 complement(1864656..1865384) 1 NC_008369.1 ABC transporter ATP-binding protein 1865384 4306636 FTH_1854 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_764235.1 1864656 R 393011 CDS YP_764236.1 115315513 4306637 complement(1865335..1866252) 1 NC_008369.1 ABC transporter ATP-binding protein 1866252 4306637 FTH_1855 Francisella tularensis subsp. holarctica OSU18 ABC transporter ATP-binding protein YP_764236.1 1865335 R 393011 CDS YP_764237.1 115315514 4306639 complement(1867664..1868128) 1 NC_008369.1 outer membrane lipoprotein 1868128 4306639 FTH_1857 Francisella tularensis subsp. holarctica OSU18 outer membrane lipoprotein YP_764237.1 1867664 R 393011 CDS YP_764238.1 115315515 4306640 complement(1868139..1868735) 1 NC_008369.1 trp repressor binding protein 1868735 wrbA 4306640 wrbA Francisella tularensis subsp. holarctica OSU18 trp repressor binding protein YP_764238.1 1868139 R 393011 CDS YP_764239.1 115315516 4306641 1868742..1869929 1 NC_008369.1 BN family tRNA processing ribonuclease 1869929 rbn 4306641 rbn Francisella tularensis subsp. holarctica OSU18 BN family tRNA processing ribonuclease YP_764239.1 1868742 D 393011 CDS YP_764240.1 115315517 4306642 1869948..1870523 1 NC_008369.1 PnuC family nicotinamide mononucleotide transporter 1870523 4306642 FTH_1860 Francisella tularensis subsp. holarctica OSU18 PnuC family nicotinamide mononucleotide transporter YP_764240.1 1869948 D 393011 CDS YP_764241.1 115315518 4306643 1870520..1872673 1 NC_008369.1 replication factor Y; primosomal protein N' 1872673 priA 4306643 priA Francisella tularensis subsp. holarctica OSU18 primosomal protein N' YP_764241.1 1870520 D 393011 CDS YP_764242.1 115315519 4306644 join(1872803..1873132,1873132..1873683) 1 NC_008369.1 ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase 1873683 isftu1 4306644 isftu1 Francisella tularensis subsp. holarctica OSU18 ISFtu1 transposase YP_764242.1 1872803 D 393011 CDS YP_764243.1 115315520 4306646 complement(1874518..1876197) 1 NC_008369.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 1876197 4306646 FTH_1864 Francisella tularensis subsp. holarctica OSU18 putative ABC transporter ATP-binding protein YP_764243.1 1874518 R 393011 CDS YP_764244.1 115315521 4306647 1876410..1877651 1 NC_008369.1 major facilitator transporter 1877651 4306647 FTH_1865 Francisella tularensis subsp. holarctica OSU18 major facilitator transporter YP_764244.1 1876410 D 393011 CDS YP_764245.1 115315522 4306648 complement(1877738..1877938) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1877938 4306648 FTH_1866 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764245.1 1877738 R 393011 CDS YP_764246.1 115315523 4306649 complement(1877950..1878162) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1878162 4306649 FTH_1867 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764246.1 1877950 R 393011 CDS YP_764247.1 115315524 4306650 1878322..1879188 1 NC_008369.1 zinc (Zn2+)-dependent hydrolase 1879188 4306650 FTH_1868 Francisella tularensis subsp. holarctica OSU18 zinc (Zn2+)-dependent hydrolase YP_764247.1 1878322 D 393011 CDS YP_764248.1 115315525 4306655 complement(1882720..1885296) 1 NC_008369.1 amino-oligopeptidase; aminopeptidase N 1885296 pepN 4306655 pepN Francisella tularensis subsp. holarctica OSU18 aminopeptidase N YP_764248.1 1882720 R 393011 CDS YP_764249.1 115315526 4306656 1885498..1885926 1 NC_008369.1 heat shock protein 1885926 hsp 4306656 hsp Francisella tularensis subsp. holarctica OSU18 heat shock protein YP_764249.1 1885498 D 393011 CDS YP_764250.1 115315527 4306657 complement(1885923..1887284) 1 NC_008369.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1887284 trpC/trpF 4306657 trpC/trpF Francisella tularensis subsp. holarctica OSU18 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_764250.1 1885923 R 393011 CDS YP_764251.1 115315528 4306659 complement(1887794..1888483) 1 NC_008369.1 peptide Met(O) reductase; protein-methionine-S-oxide reductase 1888483 msrA2 4306659 msrA2 Francisella tularensis subsp. holarctica OSU18 protein-methionine-S-oxide reductase YP_764251.1 1887794 R 393011 CDS YP_764252.1 115315529 4306660 complement(1888567..1888935) 1 NC_008369.1 hypothetical protein 1888935 4306660 FTH_1878 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764252.1 1888567 R 393011 CDS YP_764253.1 115315530 4306661 complement(1888928..1889269) 1 NC_008369.1 hypothetical protein 1889269 4306661 FTH_1879 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764253.1 1888928 R 393011 CDS YP_764254.1 115315531 4306662 complement(1889338..1889739) 1 NC_008369.1 conserved in Francisella genomes; hypothetical protein 1889739 4306662 FTH_1880 Francisella tularensis subsp. holarctica OSU18 hypothetical protein YP_764254.1 1889338 R 393011 CDS YP_764255.1 115315532 4306663 complement(1889840..1890865) 1 NC_008369.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1890865 trpD 4306663 trpD Francisella tularensis subsp. holarctica OSU18 anthranilate phosphoribosyltransferase YP_764255.1 1889840 R 393011 CDS YP_764256.1 115315533 4306664 complement(1890850..1891428) 1 NC_008369.1 glutamine amido-transferase; anthranilate synthase component II 1891428 trpG2 4306664 trpG2 Francisella tularensis subsp. holarctica OSU18 anthranilate synthase component II YP_764256.1 1890850 R 393011 CDS YP_764257.1 115315534 4306665 complement(1891432..1892976) 1 NC_008369.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1892976 trpE2 4306665 trpE2 Francisella tularensis subsp. holarctica OSU18 anthranilate synthase component I YP_764257.1 1891432 R 393011 CDS YP_764258.1 115315535 4306666 complement(1892985..1893272) 1 NC_008369.1 trp operon repressor 1893272 trpR 4306666 trpR Francisella tularensis subsp. holarctica OSU18 trp operon repressor YP_764258.1 1892985 R 393011 CDS YP_764259.1 115315536 4306669 complement(1893746..1895242) 1 NC_008369.1 ribonuclease G 1895242 cafA2 4306669 cafA2 Francisella tularensis subsp. holarctica OSU18 ribonuclease G YP_764259.1 1893746 R 393011 CDS