-- dump date 20140619_095355 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 393011000001 SEQ_END SEQ_END NC_008369.1 1895727 1895727 DR NC_008369.1; contig end 1895727..1895727 Francisella tularensis subsp. holarctica OSU18 YP_762705.1 CDS dnaA NC_008369.1 1 1476 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1..1476 Francisella tularensis subsp. holarctica OSU18 4307671 YP_762706.1 CDS dnaN NC_008369.1 1513 2616 D DNA nucleotidyltransferase (DNA-directed); DNA-directed DNA polymerase 1513..2616 Francisella tularensis subsp. holarctica OSU18 4307672 YP_762707.1 CDS isftu1 NC_008369.1 3062 3942 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1; ISFtu1 transposase complement(join(3062..3613,3613..3942)) Francisella tularensis subsp. holarctica OSU18 4307674 YP_762708.1 CDS FTH_0005 NC_008369.1 3933 4670 D CPA1 family monovalent cation:proton (H+) antiporter-1 3933..4670 Francisella tularensis subsp. holarctica OSU18 4307675 YP_762709.1 CDS FTH_0008 NC_008369.1 6907 7830 D possble periplasmic serine protease; protease 6907..7830 Francisella tularensis subsp. holarctica OSU18 4307678 YP_762710.1 CDS FTH_0009 NC_008369.1 7884 8459 D outer membrane protein OmpH 7884..8459 Francisella tularensis subsp. holarctica OSU18 4307679 YP_762711.1 CDS FTH_0010 NC_008369.1 8595 9017 D sulfur transferase 8595..9017 Francisella tularensis subsp. holarctica OSU18 4307680 YP_762712.1 CDS secB1 NC_008369.1 9045 9494 D molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 9045..9494 Francisella tularensis subsp. holarctica OSU18 4307681 YP_762713.1 CDS recA NC_008369.1 9516 10595 D catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 9516..10595 Francisella tularensis subsp. holarctica OSU18 4307682 YP_762714.1 CDS FTH_0013 NC_008369.1 10582 11034 D OraA/RecX protein 10582..11034 Francisella tularensis subsp. holarctica OSU18 4307683 YP_762715.1 CDS ssb NC_008369.1 11207 11683 D single-stranded DNA binding protein 11207..11683 Francisella tularensis subsp. holarctica OSU18 4307684 YP_762716.1 CDS ackA NC_008369.1 11789 12946 D acetate kinase 11789..12946 Francisella tularensis subsp. holarctica OSU18 4307685 YP_762717.1 CDS pta NC_008369.1 12956 15052 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 12956..15052 Francisella tularensis subsp. holarctica OSU18 4307686 YP_762718.1 CDS isftu1 NC_008369.1 15937 16817 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(15937..16488,16488..16817)) Francisella tularensis subsp. holarctica OSU18 4307688 YP_762719.1 CDS aspS NC_008369.1 17312 19084 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(17312..19084) Francisella tularensis subsp. holarctica OSU18 4307690 YP_762720.1 CDS FTH_0021 NC_008369.1 19258 20439 R major facilitator transporter complement(19258..20439) Francisella tularensis subsp. holarctica OSU18 4307691 YP_762721.1 CDS FTH_0024 NC_008369.1 22907 24109 R HAAAP family serine/threonine permease complement(22907..24109) Francisella tularensis subsp. holarctica OSU18 4307695 YP_762722.1 CDS FTH_0025 NC_008369.1 24457 24690 R conserved in Francisella genomes; hypothetical protein complement(24457..24690) Francisella tularensis subsp. holarctica OSU18 4307696 YP_762723.1 CDS pyrB NC_008369.1 26074 26994 R aspartate transcarbamylase; aspartate carbamoyltransferase complement(26074..26994) Francisella tularensis subsp. holarctica OSU18 4307698 YP_762724.1 CDS carB NC_008369.1 27136 30423 R four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit complement(27136..30423) Francisella tularensis subsp. holarctica OSU18 4307699 YP_762725.1 CDS carA NC_008369.1 30428 31594 R catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit complement(30428..31594) Francisella tularensis subsp. holarctica OSU18 4307700 YP_762726.1 CDS FTH_0030 NC_008369.1 32011 33066 D acid phosphomonoesterase; acid phosphatase 32011..33066 Francisella tularensis subsp. holarctica OSU18 4307701 YP_762727.1 CDS tpmT NC_008369.1 33190 33870 R catalyzes the S-adenosylmethionine-dependent transmethylation of thiopurine compounds; may be involved in selenium cycling by forming dimethylselenide and/or dimethyldiselenide; thiopurine S-methyltransferase complement(33190..33870) Francisella tularensis subsp. holarctica OSU18 4307702 YP_762728.1 CDS pyrC NC_008369.1 34002 35348 D Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; dihydroorotase 34002..35348 Francisella tularensis subsp. holarctica OSU18 4307703 YP_762729.1 CDS FTH_0033 NC_008369.1 35376 36416 R hypothetical protein complement(35376..36416) Francisella tularensis subsp. holarctica OSU18 4307704 YP_762730.1 CDS FTH_0035 NC_008369.1 36953 37231 D conserved in Francisella genomes; hypothetical protein 36953..37231 Francisella tularensis subsp. holarctica OSU18 4307706 YP_762731.1 CDS FTH_0036 NC_008369.1 37620 38171 D hypothetical protein 37620..38171 Francisella tularensis subsp. holarctica OSU18 4307707 YP_762732.1 CDS FTH_0037 NC_008369.1 38287 39351 R hypothetical protein complement(38287..39351) Francisella tularensis subsp. holarctica OSU18 4307708 YP_762733.1 CDS FTH_0038 NC_008369.1 39326 40291 R HlyD family secretion protein complement(39326..40291) Francisella tularensis subsp. holarctica OSU18 4307709 YP_762734.1 CDS FTH_0039 NC_008369.1 40380 40787 R conserved in Francisella genomes; hypothetical protein complement(40380..40787) Francisella tularensis subsp. holarctica OSU18 4307710 YP_762735.1 CDS lysR NC_008369.1 40913 41782 D LysR family transcriptional regulator 40913..41782 Francisella tularensis subsp. holarctica OSU18 4307711 YP_762736.1 CDS FTH_0043 NC_008369.1 43410 43958 D chorismate mutase 43410..43958 Francisella tularensis subsp. holarctica OSU18 4307714 YP_762737.1 CDS FTH_0044 NC_008369.1 44013 47387 R transglutaminase complement(44013..47387) Francisella tularensis subsp. holarctica OSU18 4307715 YP_762738.1 CDS pyrF NC_008369.1 47654 48298 D OMP decarboxylase; orotidine-5'-phosphate decarboxylase 47654..48298 Francisella tularensis subsp. holarctica OSU18 4307716 YP_762739.1 CDS pyrD NC_008369.1 48288 49046 D DHOdehase; dihydroorotate oxidase 48288..49046 Francisella tularensis subsp. holarctica OSU18 4307186 YP_762740.1 CDS FTH_0047 NC_008369.1 49410 49580 R hypothetical protein complement(49410..49580) Francisella tularensis subsp. holarctica OSU18 4307187 YP_762741.1 CDS tyrA NC_008369.1 49584 50246 R hydroxyphenylpyruvate synthase; prephenate dehydrogenase complement(49584..50246) Francisella tularensis subsp. holarctica OSU18 4307188 YP_762742.1 CDS dtd NC_008369.1 50514 50951 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(50514..50951) Francisella tularensis subsp. holarctica OSU18 4307189 YP_762743.1 CDS isftu1 NC_008369.1 54129 55009 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1; ISFtu1 transposase complement(join(54129..54680,54680..55009)) Francisella tularensis subsp. holarctica OSU18 4307192 YP_762744.1 CDS FTH_0053 NC_008369.1 55033 55584 R conserved in Francisella genomes; hypothetical protein complement(55033..55584) Francisella tularensis subsp. holarctica OSU18 4307193 YP_762745.1 CDS FTH_0054 NC_008369.1 55855 56520 R nitroreductase complement(55855..56520) Francisella tularensis subsp. holarctica OSU18 4307194 YP_762746.1 CDS FTH_0055 NC_008369.1 56745 56864 D hypothetical protein 56745..56864 Francisella tularensis subsp. holarctica OSU18 4307195 YP_762747.1 CDS FTH_0056 NC_008369.1 56923 57615 D hypothetical protein 56923..57615 Francisella tularensis subsp. holarctica OSU18 4307196 YP_762748.1 CDS FTH_0057 NC_008369.1 57612 58817 R HAAAP family aromatic amino acid transporter complement(57612..58817) Francisella tularensis subsp. holarctica OSU18 4307197 YP_762749.1 CDS gidB NC_008369.1 58917 59534 D glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 58917..59534 Francisella tularensis subsp. holarctica OSU18 4307198 YP_762750.1 CDS FTH_0059 NC_008369.1 59531 60199 D hypothetical protein 59531..60199 Francisella tularensis subsp. holarctica OSU18 4307199 YP_762751.1 CDS FTH_0060 NC_008369.1 60192 61076 R conserved in Francisella genomes; hypothetical protein complement(60192..61076) Francisella tularensis subsp. holarctica OSU18 4307200 YP_762752.1 CDS FTH_0062 NC_008369.1 62277 63413 D major facilitator transporter 62277..63413 Francisella tularensis subsp. holarctica OSU18 4307202 YP_762753.1 CDS gmhA NC_008369.1 65894 66490 D phosphoheptose isomerase 65894..66490 Francisella tularensis subsp. holarctica OSU18 4307204 YP_762754.1 CDS omlA NC_008369.1 66498 66854 D outer membrane lipoprotein 66498..66854 Francisella tularensis subsp. holarctica OSU18 4307205 YP_762755.1 CDS rpsT NC_008369.1 66928 67200 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(66928..67200) Francisella tularensis subsp. holarctica OSU18 4307206 YP_762756.1 CDS lepA NC_008369.1 67470 69254 D binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 67470..69254 Francisella tularensis subsp. holarctica OSU18 4307207 YP_762757.1 CDS mnmA NC_008369.1 69202 70347 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 69202..70347 Francisella tularensis subsp. holarctica OSU18 4307208 YP_762758.1 CDS FTH_0069 NC_008369.1 70367 71347 R conserved in Francisella genomes; hypothetical protein complement(70367..71347) Francisella tularensis subsp. holarctica OSU18 4307209 YP_762759.1 CDS def NC_008369.1 71441 71959 R PDF; peptide deformylase complement(71441..71959) Francisella tularensis subsp. holarctica OSU18 4307210 YP_762760.1 CDS ribH NC_008369.1 71962 72405 R riboflavin synthase beta subunit complement(71962..72405) Francisella tularensis subsp. holarctica OSU18 4307211 YP_762761.1 CDS ribA NC_008369.1 72415 73626 R riboflavin biosynthesis protein; GTP-cyclohydrolase II complement(72415..73626) Francisella tularensis subsp. holarctica OSU18 4307212 YP_762762.1 CDS ribB NC_008369.1 73619 74224 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(73619..74224) Francisella tularensis subsp. holarctica OSU18 4307213 YP_762763.1 CDS ribD NC_008369.1 74217 75284 R bifunctional riboflavin-specific deaminase and HTP reductase; bifunctional 5-amino-6-(5-phosphoribosylamino)uracil reductase/ diaminohydroxyphosphoribosylaminopyrimidine deaminase complement(74217..75284) Francisella tularensis subsp. holarctica OSU18 4307214 YP_762764.1 CDS cybB NC_008369.1 78255 78848 R cytochrome b561 complement(78255..78848) Francisella tularensis subsp. holarctica OSU18 4307218 YP_762765.1 CDS nhaA NC_008369.1 79820 80971 D exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 79820..80971 Francisella tularensis subsp. holarctica OSU18 4307220 YP_762766.1 CDS FTH_0081 NC_008369.1 81036 81755 D hypothetical protein 81036..81755 Francisella tularensis subsp. holarctica OSU18 4307221 YP_762767.1 CDS FTH_0082 NC_008369.1 81761 82501 R acyltransferase complement(81761..82501) Francisella tularensis subsp. holarctica OSU18 4307222 YP_762768.1 CDS FTH_0083 NC_008369.1 82515 83267 R acyltransferase complement(82515..83267) Francisella tularensis subsp. holarctica OSU18 4307223 YP_762769.1 CDS FTH_0084 NC_008369.1 83430 83753 R ferredoxin complement(83430..83753) Francisella tularensis subsp. holarctica OSU18 4307224 YP_762770.1 CDS FTH_0085 NC_008369.1 83984 84625 D conserved in Francisella genomes; hypothetical protein 83984..84625 Francisella tularensis subsp. holarctica OSU18 4307225 YP_762771.1 CDS purT NC_008369.1 85358 86518 R non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 complement(85358..86518) Francisella tularensis subsp. holarctica OSU18 4307227 YP_762772.1 CDS FTH_0088 NC_008369.1 86572 88764 R 1,4-beta-poly-N-acetylglucosaminidase; chitinase complement(86572..88764) Francisella tularensis subsp. holarctica OSU18 4307228 YP_762773.1 CDS clpB NC_008369.1 89015 91594 R caseinolytic protease; endopeptidase Clp complement(89015..91594) Francisella tularensis subsp. holarctica OSU18 4307229 YP_762774.1 CDS FTH_0091 NC_008369.1 92540 92893 D conserved in Francisella genomes; hypothetical protein 92540..92893 Francisella tularensis subsp. holarctica OSU18 4307231 YP_762775.1 CDS trpA NC_008369.1 92948 93757 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(92948..93757) Francisella tularensis subsp. holarctica OSU18 4307232 YP_762776.1 CDS trpB NC_008369.1 93757 94947 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(93757..94947) Francisella tularensis subsp. holarctica OSU18 4307233 YP_762777.1 CDS FTH_0094 NC_008369.1 95034 96539 R carboxypeptidase complement(95034..96539) Francisella tularensis subsp. holarctica OSU18 4307234 YP_762778.1 CDS FTH_0095 NC_008369.1 96475 97893 R Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein complement(96475..97893) Francisella tularensis subsp. holarctica OSU18 4307235 YP_762779.1 CDS FTH_0097 NC_008369.1 98364 98774 R conserved in Francisella genomes; hypothetical protein complement(98364..98774) Francisella tularensis subsp. holarctica OSU18 4307237 YP_762780.1 CDS FTH_0098 NC_008369.1 98795 99187 R conserved in Francisella genomes; hypothetical protein complement(98795..99187) Francisella tularensis subsp. holarctica OSU18 4307238 YP_762781.1 CDS isftu1 NC_008369.1 99988 100868 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(99988..100317,100317..100868) Francisella tularensis subsp. holarctica OSU18 4307240 YP_762782.1 CDS iglA2 NC_008369.1 102493 103083 D IglA2; intracellular growth locus A protein 102493..103083 Francisella tularensis subsp. holarctica OSU18 4307243 YP_762783.1 CDS iglB2 NC_008369.1 103073 104617 D IglB2; intracellular growth locus B protein 103073..104617 Francisella tularensis subsp. holarctica OSU18 4307244 YP_762784.1 CDS iglC2 NC_008369.1 104628 105263 D IglC2; intracellular growth locus C protein 104628..105263 Francisella tularensis subsp. holarctica OSU18 4307245 YP_762785.1 CDS iglD2 NC_008369.1 105284 106480 D IglD2; intracellular growth locus D protein 105284..106480 Francisella tularensis subsp. holarctica OSU18 4307246 YP_762786.1 CDS FTH_0107 NC_008369.1 106487 107062 R conserved in Francisella genomes; hypothetical protein complement(106487..107062) Francisella tularensis subsp. holarctica OSU18 4307247 YP_762787.1 CDS pdpC2 NC_008369.1 107080 111066 R PdpC2; conserved in Francisella genomes; protein PdpC complement(107080..111066) Francisella tularensis subsp. holarctica OSU18 4307248 YP_762788.1 CDS FTH_0109 NC_008369.1 111106 111879 R conserved in Francisella genomes; hypothetical protein complement(111106..111879) Francisella tularensis subsp. holarctica OSU18 4307249 YP_762789.1 CDS FTH_0110 NC_008369.1 111845 112996 R conserved in Francisella genomes; hypothetical protein complement(111845..112996) Francisella tularensis subsp. holarctica OSU18 4307250 YP_762790.1 CDS FTH_0111 NC_008369.1 113018 113641 R conserved in Francisella genomes; hypothetical protein complement(113018..113641) Francisella tularensis subsp. holarctica OSU18 4307251 YP_762791.1 CDS FTH_0112 NC_008369.1 113654 115084 R hypothetical protein complement(113654..115084) Francisella tularensis subsp. holarctica OSU18 4307252 YP_762792.1 CDS FTH_0113 NC_008369.1 115097 115618 R hypothetical protein complement(115097..115618) Francisella tularensis subsp. holarctica OSU18 4307253 YP_762793.1 CDS FTH_0115 NC_008369.1 117355 117849 R conserved in Francisella genomes; hypothetical protein complement(117355..117849) Francisella tularensis subsp. holarctica OSU18 4307255 YP_762794.1 CDS FTH_0116 NC_008369.1 117862 118239 R conserved in Francisella genomes; hypothetical protein complement(117862..118239) Francisella tularensis subsp. holarctica OSU18 4307256 YP_762795.1 CDS pdpB2 NC_008369.1 118229 121510 R PdpB2; conserved in Francisella genomes; protein PdpB complement(118229..121510) Francisella tularensis subsp. holarctica OSU18 4307257 YP_762796.1 CDS pdpA2 NC_008369.1 121515 123977 R PdpA2; conserved in Francisella genomes; protein PdpA complement(121515..123977) Francisella tularensis subsp. holarctica OSU18 4307258 YP_762797.1 CDS FTH_0119 NC_008369.1 129549 130265 D formate dehydrogenase 129549..130265 Francisella tularensis subsp. holarctica OSU18 4307264 YP_762798.1 CDS ilvE NC_008369.1 132582 133469 R branched-chain amino acid aminotransferase; branched-chain-amino-acid transaminase complement(132582..133469) Francisella tularensis subsp. holarctica OSU18 4307267 YP_762799.1 CDS ppdK NC_008369.1 133870 136503 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase complement(133870..136503) Francisella tularensis subsp. holarctica OSU18 4307268 YP_762800.1 CDS FTH_0124 NC_008369.1 137330 139573 R FeoB family ferrous iron (Fe2+) uptake protein complement(137330..139573) Francisella tularensis subsp. holarctica OSU18 4307269 YP_762801.1 CDS FTH_0125 NC_008369.1 139674 140162 R conserved in Francisella genomes; hypothetical protein complement(139674..140162) Francisella tularensis subsp. holarctica OSU18 4307270 YP_762802.1 CDS isftu1 NC_008369.1 140119 140999 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(140119..140670,140670..140999)) Francisella tularensis subsp. holarctica OSU18 4307271 YP_762803.1 CDS FTH_0129 NC_008369.1 142771 143739 R LpsA; lipopolysaccharide biosynthesis protein complement(142771..143739) Francisella tularensis subsp. holarctica OSU18 4307274 YP_762804.1 CDS FTH_0130 NC_008369.1 143928 145778 D ribonuclease II 143928..145778 Francisella tularensis subsp. holarctica OSU18 4307275 YP_762805.1 CDS FTH_0131 NC_008369.1 146115 146783 D carboxylesterase/phospholipase family protein 146115..146783 Francisella tularensis subsp. holarctica OSU18 4307276 YP_762806.1 CDS hemC NC_008369.1 146780 147682 D transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 146780..147682 Francisella tularensis subsp. holarctica OSU18 4307277 YP_762807.1 CDS FTH_0133 NC_008369.1 147683 148018 D may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 147683..148018 Francisella tularensis subsp. holarctica OSU18 4307278 YP_762808.1 CDS FTH_0134 NC_008369.1 148071 148478 D conserved in Francisella genomes; hypothetical protein 148071..148478 Francisella tularensis subsp. holarctica OSU18 4307279 YP_762809.1 CDS FTH_0135 NC_008369.1 148618 148779 D conserved in Francisella genomes; hypothetical protein 148618..148779 Francisella tularensis subsp. holarctica OSU18 4307280 YP_762810.1 CDS FTH_0136 NC_008369.1 148856 149209 D conserved in Francisella genomes; hypothetical protein 148856..149209 Francisella tularensis subsp. holarctica OSU18 4307281 YP_762811.1 CDS FTH_0137 NC_008369.1 149206 149379 R hypothetical protein complement(149206..149379) Francisella tularensis subsp. holarctica OSU18 4307282 YP_762812.1 CDS FTH_0138 NC_008369.1 149508 151307 D ABC transporter ATP-binding protein 149508..151307 Francisella tularensis subsp. holarctica OSU18 4307283 YP_762813.1 CDS FTH_0139 NC_008369.1 151326 152642 D ABC transporter ATP-binding protein 151326..152642 Francisella tularensis subsp. holarctica OSU18 4307284 YP_762814.1 CDS FTH_0141 NC_008369.1 154351 156237 D CPA1 family sodium:proton (Na+:H+) antiporter-1 154351..156237 Francisella tularensis subsp. holarctica OSU18 4307286 YP_762815.1 CDS FTH_0142 NC_008369.1 156222 156761 D carbonic anhydrase; carbonate dehydratase 156222..156761 Francisella tularensis subsp. holarctica OSU18 4307287 YP_762816.1 CDS lolB NC_008369.1 156712 157356 D outer membrane lipoprotein 156712..157356 Francisella tularensis subsp. holarctica OSU18 4307288 YP_762817.1 CDS ipk NC_008369.1 157344 158171 D An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 157344..158171 Francisella tularensis subsp. holarctica OSU18 4307289 YP_762818.1 CDS FTH_0145 NC_008369.1 158360 158680 D conserved in Francisella genomes; hypothetical protein 158360..158680 Francisella tularensis subsp. holarctica OSU18 4307291 YP_762819.1 CDS isftu1 NC_008369.1 158704 159584 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(158704..159033,159033..159584) Francisella tularensis subsp. holarctica OSU18 4307292 YP_762820.1 CDS FTH_0147 NC_008369.1 159556 159825 D hypothetical protein 159556..159825 Francisella tularensis subsp. holarctica OSU18 4307293 YP_762821.1 CDS FTH_0149 NC_008369.1 160142 160345 R hypothetical protein complement(160142..160345) Francisella tularensis subsp. holarctica OSU18 4307295 YP_762822.1 CDS FTH_0150 NC_008369.1 160426 161421 R PiT family inorganic phosphate transporter complement(160426..161421) Francisella tularensis subsp. holarctica OSU18 4307296 YP_762823.1 CDS FTH_0151 NC_008369.1 161439 162095 R conserved in Francisella genomes; hypothetical protein complement(161439..162095) Francisella tularensis subsp. holarctica OSU18 4307297 YP_762824.1 CDS ybgK NC_008369.1 163884 164660 R hydrolase subunit complement(163884..164660) Francisella tularensis subsp. holarctica OSU18 4307299 YP_762825.1 CDS FTH_0154 NC_008369.1 164781 165398 R LamB/YcsF family protein complement(164781..165398) Francisella tularensis subsp. holarctica OSU18 4307300 YP_762826.1 CDS FTH_0155 NC_008369.1 165398 166015 R hypothetical protein complement(165398..166015) Francisella tularensis subsp. holarctica OSU18 4307978 YP_762827.1 CDS isftu1 NC_008369.1 167091 167971 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(167091..167642,167642..167971)) Francisella tularensis subsp. holarctica OSU18 4307980 YP_762828.1 CDS usp NC_008369.1 168331 169167 R universal stress protein complement(168331..169167) Francisella tularensis subsp. holarctica OSU18 4307982 YP_762829.1 CDS FTH_0160 NC_008369.1 169243 171984 R DNA/RNA helicase complement(169243..171984) Francisella tularensis subsp. holarctica OSU18 4307983 YP_762830.1 CDS FTH_0161 NC_008369.1 171968 172747 R hypothetical protein complement(171968..172747) Francisella tularensis subsp. holarctica OSU18 4307984 YP_762831.1 CDS FTH_0162 NC_008369.1 172819 173382 R hypothetical protein complement(172819..173382) Francisella tularensis subsp. holarctica OSU18 4307985 YP_762832.1 CDS FTH_0163 NC_008369.1 173459 173635 D hypothetical protein 173459..173635 Francisella tularensis subsp. holarctica OSU18 4307986 YP_762833.1 CDS FTH_0164 NC_008369.1 173724 174194 D conserved in Francisella genomes; hypothetical protein 173724..174194 Francisella tularensis subsp. holarctica OSU18 4307987 YP_762834.1 CDS FTH_0165 NC_008369.1 174205 175077 R tetrapyrrole methyltransferase complement(174205..175077) Francisella tularensis subsp. holarctica OSU18 4307988 YP_762835.1 CDS aroE1 NC_008369.1 176517 177290 R 5-dehydroshikimate reductase; shikimate dehydrogenase complement(176517..177290) Francisella tularensis subsp. holarctica OSU18 4307990 YP_762836.1 CDS FTH_0168 NC_008369.1 177417 177875 D conserved in Francisella genomes; hypothetical protein 177417..177875 Francisella tularensis subsp. holarctica OSU18 4307991 YP_762837.1 CDS rpmH NC_008369.1 177972 178106 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 177972..178106 Francisella tularensis subsp. holarctica OSU18 4307992 YP_762838.1 CDS rnpA NC_008369.1 178096 178449 D ribonuclease P 178096..178449 Francisella tularensis subsp. holarctica OSU18 4307993 YP_762839.1 CDS FTH_0171 NC_008369.1 178461 178673 D hypothetical protein 178461..178673 Francisella tularensis subsp. holarctica OSU18 4307994 YP_762840.1 CDS FTH_0172 NC_008369.1 178682 180337 D inner membrane protein 178682..180337 Francisella tularensis subsp. holarctica OSU18 4307995 YP_762841.1 CDS FTH_0173 NC_008369.1 180344 181243 D acyltransferase 180344..181243 Francisella tularensis subsp. holarctica OSU18 4307996 YP_762842.1 CDS FTH_0174 NC_008369.1 181304 182227 D acyltransferase 181304..182227 Francisella tularensis subsp. holarctica OSU18 4307997 YP_762843.1 CDS FTH_0175 NC_008369.1 182240 182647 D type IV pilus assembly protein 182240..182647 Francisella tularensis subsp. holarctica OSU18 4307998 YP_762844.1 CDS efp NC_008369.1 182687 183256 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 182687..183256 Francisella tularensis subsp. holarctica OSU18 4307999 YP_762845.1 CDS FTH_0177 NC_008369.1 183259 183795 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 183259..183795 Francisella tularensis subsp. holarctica OSU18 4308000 YP_762846.1 CDS FTH_0180 NC_008369.1 184909 186027 R ABC transporter ATP-binding protein complement(184909..186027) Francisella tularensis subsp. holarctica OSU18 4308003 YP_762847.1 CDS FTH_0181 NC_008369.1 186095 186835 R hypothetical protein complement(186095..186835) Francisella tularensis subsp. holarctica OSU18 4308004 YP_762848.1 CDS FTH_0182 NC_008369.1 186914 187012 R conserved in Francisella genomes; hypothetical protein complement(186914..187012) Francisella tularensis subsp. holarctica OSU18 4308005 YP_762849.1 CDS cydB NC_008369.1 187028 188221 R cytochrome d ubiquinol oxidase subunit II complement(187028..188221) Francisella tularensis subsp. holarctica OSU18 4308006 YP_762850.1 CDS cydA NC_008369.1 188232 189986 R cytochrome d ubiquinol oxidase subunit I complement(188232..189986) Francisella tularensis subsp. holarctica OSU18 4308007 YP_762851.1 CDS FTH_0185 NC_008369.1 190439 191806 R major facilitator transporter complement(190439..191806) Francisella tularensis subsp. holarctica OSU18 4308008 YP_762852.1 CDS cyoA NC_008369.1 192166 193068 D cytochrome o ubiquinol oxidase subunit II 192166..193068 Francisella tularensis subsp. holarctica OSU18 4308009 YP_762853.1 CDS cyoB NC_008369.1 193107 195137 D cytochrome o ubiquinol oxidase subunit I 193107..195137 Francisella tularensis subsp. holarctica OSU18 4308010 YP_762854.1 CDS cyoC NC_008369.1 195134 195736 D cytochrome o ubiquinol oxidase subunit III 195134..195736 Francisella tularensis subsp. holarctica OSU18 4308011 YP_762855.1 CDS cyoD NC_008369.1 195738 196070 D cytochrome o ubiquinol oxidase subunit IV 195738..196070 Francisella tularensis subsp. holarctica OSU18 4308012 YP_762856.1 CDS cyoE NC_008369.1 196101 196949 D converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 196101..196949 Francisella tularensis subsp. holarctica OSU18 4308013 YP_762857.1 CDS lpxD NC_008369.1 197094 198137 R UDP-3-[O-3-hydroxymyristoyl] glucosamine N-acyltransferase complement(197094..198137) Francisella tularensis subsp. holarctica OSU18 4308014 YP_762858.1 CDS FTH_0192 NC_008369.1 198212 198907 R hypothetical protein complement(198212..198907) Francisella tularensis subsp. holarctica OSU18 4308015 YP_762859.1 CDS pdxY NC_008369.1 198907 199758 R pyridoxamine kinase; pyridoxal kinase complement(198907..199758) Francisella tularensis subsp. holarctica OSU18 4308016 YP_762860.1 CDS FTH_0194 NC_008369.1 199765 200199 R conserved in Francisella genomes; hypothetical protein complement(199765..200199) Francisella tularensis subsp. holarctica OSU18 4308017 YP_762861.1 CDS moxR NC_008369.1 200345 201301 D MoxR family ATPase 200345..201301 Francisella tularensis subsp. holarctica OSU18 4308018 YP_762862.1 CDS FTH_0196 NC_008369.1 201314 202225 D hypothetical protein 201314..202225 Francisella tularensis subsp. holarctica OSU18 4308019 YP_762863.1 CDS FTH_0197 NC_008369.1 202215 202691 D hypothetical protein 202215..202691 Francisella tularensis subsp. holarctica OSU18 4308020 YP_762864.1 CDS FTH_0198 NC_008369.1 202670 203689 D hypothetical protein 202670..203689 Francisella tularensis subsp. holarctica OSU18 4308021 YP_762865.1 CDS FTH_0199 NC_008369.1 203691 204689 D hypothetical protein 203691..204689 Francisella tularensis subsp. holarctica OSU18 4308022 YP_762866.1 CDS FTH_0200 NC_008369.1 204698 205414 D hypothetical protein 204698..205414 Francisella tularensis subsp. holarctica OSU18 4308023 YP_762867.1 CDS FTH_0201 NC_008369.1 205404 207029 D hypothetical protein 205404..207029 Francisella tularensis subsp. holarctica OSU18 4308024 YP_762868.1 CDS pcp NC_008369.1 207030 207704 D 5-oxoprolyl-peptidase; pyroglutamyl-peptidase I 207030..207704 Francisella tularensis subsp. holarctica OSU18 4308025 YP_762869.1 CDS FTH_0203 NC_008369.1 207712 208194 D putative cytochrome c-type biogenesis protein 207712..208194 Francisella tularensis subsp. holarctica OSU18 4308026 YP_762870.1 CDS holC NC_008369.1 208225 208665 D DNA nucleotidyltransferase (DNA-directed); DNA polymerase III subunit chi 208225..208665 Francisella tularensis subsp. holarctica OSU18 4308027 YP_762871.1 CDS valS NC_008369.1 208797 211556 D valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 208797..211556 Francisella tularensis subsp. holarctica OSU18 4308028 YP_762872.1 CDS FTH_0206 NC_008369.1 211585 212472 D conserved in Francisella genomes; hypothetical protein 211585..212472 Francisella tularensis subsp. holarctica OSU18 4308029 YP_762873.1 CDS FTH_0207 NC_008369.1 212427 213413 D conserved in Francisella genomes; hypothetical protein 212427..213413 Francisella tularensis subsp. holarctica OSU18 4308030 YP_762874.1 CDS lldD NC_008369.1 213910 215067 R cytochrome b2; L-lactate dehydrogenase complement(213910..215067) Francisella tularensis subsp. holarctica OSU18 4308032 YP_762875.1 CDS nfnB NC_008369.1 215057 215740 R catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase complement(215057..215740) Francisella tularensis subsp. holarctica OSU18 4308033 YP_762876.1 CDS FTH_0211 NC_008369.1 215880 216257 D MutT/nudix hydrolase 215880..216257 Francisella tularensis subsp. holarctica OSU18 4308034 YP_762877.1 CDS fumC NC_008369.1 216430 217821 D class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 216430..217821 Francisella tularensis subsp. holarctica OSU18 4308035 YP_762878.1 CDS gltX NC_008369.1 217951 219357 D Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 217951..219357 Francisella tularensis subsp. holarctica OSU18 4308036 YP_762879.1 CDS FTH_0216 NC_008369.1 221382 222674 D APC family amino acid-polyamine-organocation transporter 221382..222674 Francisella tularensis subsp. holarctica OSU18 4308039 YP_762880.1 CDS FTH_0217 NC_008369.1 223168 224091 R hypothetical protein complement(223168..224091) Francisella tularensis subsp. holarctica OSU18 4308041 YP_762881.1 CDS folA NC_008369.1 224173 224715 R tetrahydrofolate dehydrogenase; dihydrofolate reductase type I complement(224173..224715) Francisella tularensis subsp. holarctica OSU18 4308042 YP_762882.1 CDS rpsB NC_008369.1 224908 225627 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 224908..225627 Francisella tularensis subsp. holarctica OSU18 4308043 YP_762883.1 CDS tsf NC_008369.1 225649 226518 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 225649..226518 Francisella tularensis subsp. holarctica OSU18 4308044 YP_762884.1 CDS pyrH NC_008369.1 226522 227271 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 226522..227271 Francisella tularensis subsp. holarctica OSU18 4308045 YP_762885.1 CDS frr NC_008369.1 227301 227858 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 227301..227858 Francisella tularensis subsp. holarctica OSU18 4308046 YP_762886.1 CDS uppS NC_008369.1 227891 228664 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 227891..228664 Francisella tularensis subsp. holarctica OSU18 4308047 YP_762887.1 CDS FTH_0224 NC_008369.1 228678 229472 D CDP-diacylglycerol synthase; phosphatidate cytidylyltransferase 228678..229472 Francisella tularensis subsp. holarctica OSU18 4308048 YP_762888.1 CDS dut NC_008369.1 229482 229928 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 229482..229928 Francisella tularensis subsp. holarctica OSU18 4308049 YP_762889.1 CDS pgsA NC_008369.1 229932 230528 D 3-phosphatidyl-1'-glycerol-3??-phosphate synthase; phosphatidylglycerophosphate synthetase 229932..230528 Francisella tularensis subsp. holarctica OSU18 4308050 YP_762890.1 CDS rpsL NC_008369.1 230663 231037 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 230663..231037 Francisella tularensis subsp. holarctica OSU18 4308051 YP_762891.1 CDS rpsG NC_008369.1 231076 231549 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 231076..231549 Francisella tularensis subsp. holarctica OSU18 4308052 YP_762892.1 CDS fusA NC_008369.1 231564 233678 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 231564..233678 Francisella tularensis subsp. holarctica OSU18 4308053 YP_762893.1 CDS rpsJ NC_008369.1 233699 234016 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 233699..234016 Francisella tularensis subsp. holarctica OSU18 4308054 YP_762894.1 CDS rplC NC_008369.1 234120 234752 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 234120..234752 Francisella tularensis subsp. holarctica OSU18 4308055 YP_762895.1 CDS rplD NC_008369.1 234785 235408 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 234785..235408 Francisella tularensis subsp. holarctica OSU18 4308056 YP_762896.1 CDS rplW NC_008369.1 235405 235704 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 235405..235704 Francisella tularensis subsp. holarctica OSU18 4308057 YP_762897.1 CDS rplB NC_008369.1 235726 236550 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 235726..236550 Francisella tularensis subsp. holarctica OSU18 4308058 YP_762898.1 CDS rpsS NC_008369.1 236565 236843 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 236565..236843 Francisella tularensis subsp. holarctica OSU18 4308059 YP_762899.2 CDS rplV NC_008369.1 236859 237194 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 236859..237194 Francisella tularensis subsp. holarctica OSU18 4308060 YP_762900.1 CDS rpsC NC_008369.1 237209 237880 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 237209..237880 Francisella tularensis subsp. holarctica OSU18 4308061 YP_762901.1 CDS rplP NC_008369.1 237880 238293 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 237880..238293 Francisella tularensis subsp. holarctica OSU18 4308062 YP_762902.1 CDS rpmC NC_008369.1 238293 238493 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 238293..238493 Francisella tularensis subsp. holarctica OSU18 4308063 YP_762903.1 CDS rpsQ NC_008369.1 238506 238757 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 238506..238757 Francisella tularensis subsp. holarctica OSU18 4308064 YP_762904.1 CDS rplN NC_008369.1 238849 239217 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 238849..239217 Francisella tularensis subsp. holarctica OSU18 4308065 YP_762905.1 CDS rplX NC_008369.1 239239 239556 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 239239..239556 Francisella tularensis subsp. holarctica OSU18 4308066 YP_762906.1 CDS rplE NC_008369.1 239568 240107 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 239568..240107 Francisella tularensis subsp. holarctica OSU18 4308067 YP_762907.1 CDS rpsN NC_008369.1 240126 240431 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 240126..240431 Francisella tularensis subsp. holarctica OSU18 4308068 YP_762908.1 CDS rpsH NC_008369.1 240448 240846 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 240448..240846 Francisella tularensis subsp. holarctica OSU18 4308069 YP_762909.1 CDS rplF NC_008369.1 240865 241401 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 240865..241401 Francisella tularensis subsp. holarctica OSU18 4308070 YP_762910.1 CDS rplR NC_008369.1 241424 241777 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 241424..241777 Francisella tularensis subsp. holarctica OSU18 4307140 YP_762911.1 CDS rpsE NC_008369.1 241805 242305 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 241805..242305 Francisella tularensis subsp. holarctica OSU18 4307141 YP_762912.1 CDS rpmD NC_008369.1 242312 242497 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 242312..242497 Francisella tularensis subsp. holarctica OSU18 4307142 YP_762913.1 CDS rplO NC_008369.1 242504 242935 D late assembly protein; 50S ribosomal protein L15 242504..242935 Francisella tularensis subsp. holarctica OSU18 4307143 YP_762914.1 CDS secY NC_008369.1 242946 244271 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 242946..244271 Francisella tularensis subsp. holarctica OSU18 4307144 YP_762915.1 CDS rpsM NC_008369.1 244525 244881 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 244525..244881 Francisella tularensis subsp. holarctica OSU18 4307146 YP_762916.1 CDS rpsK NC_008369.1 244920 245309 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 244920..245309 Francisella tularensis subsp. holarctica OSU18 4307147 YP_762917.1 CDS rpsD NC_008369.1 245331 245951 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 245331..245951 Francisella tularensis subsp. holarctica OSU18 4307148 YP_762918.1 CDS rpoA1 NC_008369.1 246009 246980 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 246009..246980 Francisella tularensis subsp. holarctica OSU18 4307149 YP_762919.1 CDS rplQ NC_008369.1 247025 247462 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 247025..247462 Francisella tularensis subsp. holarctica OSU18 4307150 YP_762920.1 CDS FTH_0261 NC_008369.1 249278 250273 D conserved in Francisella genomes; hypothetical protein 249278..250273 Francisella tularensis subsp. holarctica OSU18 4307154 YP_762921.1 CDS isftu1 NC_008369.1 250469 251349 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(250469..251020,251020..251349)) Francisella tularensis subsp. holarctica OSU18 4307155 YP_762922.1 CDS FTH_0268 NC_008369.1 256600 257949 R converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase complement(256600..257949) Francisella tularensis subsp. holarctica OSU18 4307161 YP_762923.1 CDS lysA1 NC_008369.1 260000 261169 D DAP decarboxylase; diaminopimelate decarboxylase 260000..261169 Francisella tularensis subsp. holarctica OSU18 4307164 YP_762924.1 CDS gabP NC_008369.1 261181 262560 D APC family amino acid-polyamine-organocation transporter 261181..262560 Francisella tularensis subsp. holarctica OSU18 4307165 YP_762925.1 CDS FTH_0274 NC_008369.1 263037 263609 R 6-O-methylguanine-DNA methyltransferase; methylated-DNA--[protein]-cysteine S-methyltransferase complement(263037..263609) Francisella tularensis subsp. holarctica OSU18 4307167 YP_762926.1 CDS FTH_0275 NC_008369.1 263639 264358 D hypothetical protein 263639..264358 Francisella tularensis subsp. holarctica OSU18 4307168 YP_762927.1 CDS FTH_0276 NC_008369.1 264361 265779 D pyruvate/2-oxoglutarate dehydrogenase 264361..265779 Francisella tularensis subsp. holarctica OSU18 4307169 YP_762928.1 CDS FTH_0277 NC_008369.1 265776 266345 D phosphatidylglycerophosphate synthase 265776..266345 Francisella tularensis subsp. holarctica OSU18 4307170 YP_762929.1 CDS FTH_0278 NC_008369.1 266342 266671 D conserved in Francisella genomes; hypothetical protein 266342..266671 Francisella tularensis subsp. holarctica OSU18 4307171 YP_762930.1 CDS dnaJ1 NC_008369.1 267656 268582 D chaperone DnaJ 267656..268582 Francisella tularensis subsp. holarctica OSU18 4307173 YP_762931.1 CDS FTH_0281 NC_008369.1 268572 269456 R DMT superfamily drug/metabolite transporter complement(268572..269456) Francisella tularensis subsp. holarctica OSU18 4307174 YP_762932.1 CDS FTH_0282 NC_008369.1 269647 270843 D HAAAP family hydroxy/aromatic amino acid permease 269647..270843 Francisella tularensis subsp. holarctica OSU18 4307175 YP_762933.1 CDS FTH_0283 NC_008369.1 270877 271233 D conserved in Francisella genomes; hypothetical protein 270877..271233 Francisella tularensis subsp. holarctica OSU18 4307176 YP_762934.1 CDS spoT1 NC_008369.1 271536 273545 D GTP pyrophosphokinase; GTP diphosphokinase 271536..273545 Francisella tularensis subsp. holarctica OSU18 4307177 YP_762935.1 CDS FTH_0285 NC_008369.1 273661 274293 R conserved in Francisella genomes; hypothetical protein complement(273661..274293) Francisella tularensis subsp. holarctica OSU18 4307178 YP_762936.1 CDS FTH_0286 NC_008369.1 274370 274948 R conserved in Francisella genomes; hypothetical protein complement(274370..274948) Francisella tularensis subsp. holarctica OSU18 4307179 YP_762937.1 CDS FTH_0287 NC_008369.1 275036 275650 D conserved in Francisella genomes; hypothetical protein 275036..275650 Francisella tularensis subsp. holarctica OSU18 4307180 YP_762938.1 CDS FTH_0288 NC_008369.1 275657 276382 R hypothetical protein complement(275657..276382) Francisella tularensis subsp. holarctica OSU18 4307181 YP_762939.1 CDS xerC NC_008369.1 276382 277260 R integrase/recombinase XerC complement(276382..277260) Francisella tularensis subsp. holarctica OSU18 4307182 YP_762940.1 CDS FTH_0290 NC_008369.1 277270 278481 R HAAAP family hydroxy/aromatic amino acid permease complement(277270..278481) Francisella tularensis subsp. holarctica OSU18 4307183 YP_762941.1 CDS FTH_0291 NC_008369.1 278505 279509 R hypothetical protein complement(278505..279509) Francisella tularensis subsp. holarctica OSU18 4307184 YP_762942.1 CDS FTH_0292 NC_008369.1 279515 279727 R hypothetical protein complement(279515..279727) Francisella tularensis subsp. holarctica OSU18 4307185 YP_762943.1 CDS secB2 NC_008369.1 279921 280364 R molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB complement(279921..280364) Francisella tularensis subsp. holarctica OSU18 4307602 YP_762944.1 CDS mutS NC_008369.1 280441 283008 R This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS complement(280441..283008) Francisella tularensis subsp. holarctica OSU18 4307603 YP_762945.1 CDS accA NC_008369.1 283142 284089 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 283142..284089 Francisella tularensis subsp. holarctica OSU18 4307604 YP_762946.1 CDS FTH_0296 NC_008369.1 284109 284612 D conserved in Francisella genomes; hypothetical protein 284109..284612 Francisella tularensis subsp. holarctica OSU18 4307605 YP_762947.1 CDS FTH_0297 NC_008369.1 284593 285606 D conserved in Francisella genomes; hypothetical protein 284593..285606 Francisella tularensis subsp. holarctica OSU18 4307606 YP_762948.1 CDS FTH_0298 NC_008369.1 285615 287576 D conserved in Francisella genomes; hypothetical protein 285615..287576 Francisella tularensis subsp. holarctica OSU18 4307607 YP_762949.1 CDS murQ NC_008369.1 287573 288457 D catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 287573..288457 Francisella tularensis subsp. holarctica OSU18 4307608 YP_762950.1 CDS FTH_0300 NC_008369.1 288459 288854 D conserved in Francisella genomes; hypothetical protein 288459..288854 Francisella tularensis subsp. holarctica OSU18 4307609 YP_762951.1 CDS FTH_0303 NC_008369.1 290668 291243 D conserved in Francisella genomes; hypothetical protein 290668..291243 Francisella tularensis subsp. holarctica OSU18 4307612 YP_762952.1 CDS FTH_0304 NC_008369.1 291462 291635 D hypothetical protein 291462..291635 Francisella tularensis subsp. holarctica OSU18 4307613 YP_762953.1 CDS nhaP NC_008369.1 291640 292938 R CPA1 family monovalent cation:proton (H+) antiporter-1 complement(291640..292938) Francisella tularensis subsp. holarctica OSU18 4307614 YP_762954.1 CDS FTH_0306 NC_008369.1 292948 293673 R conserved in Francisella genomes; hypothetical protein complement(292948..293673) Francisella tularensis subsp. holarctica OSU18 4307615 YP_762955.1 CDS trpS NC_008369.1 293675 294679 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(293675..294679) Francisella tularensis subsp. holarctica OSU18 4307616 YP_762956.1 CDS coaE NC_008369.1 294976 295590 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(294976..295590) Francisella tularensis subsp. holarctica OSU18 4307619 YP_762957.1 CDS FTH_0309 NC_008369.1 295719 296855 D hypothetical protein 295719..296855 Francisella tularensis subsp. holarctica OSU18 4307620 YP_762958.1 CDS aceE NC_008369.1 297139 299820 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 297139..299820 Francisella tularensis subsp. holarctica OSU18 4307621 YP_762959.1 CDS aceF NC_008369.1 299838 301433 D acetyl-CoA:dihydrolipoamide S-acetyltransferase; dihydrolipoamide acetyltransferase 299838..301433 Francisella tularensis subsp. holarctica OSU18 4307622 YP_762960.1 CDS lpd NC_008369.1 301447 302859 D dehydrolipoate dehydrogenase; dihydrolipoamide dehydrogenase 301447..302859 Francisella tularensis subsp. holarctica OSU18 4307623 YP_762961.1 CDS isftu1 NC_008369.1 303229 304109 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(303229..303558,303558..304109) Francisella tularensis subsp. holarctica OSU18 4307625 YP_762962.1 CDS mutT NC_008369.1 304237 304884 D MutT/nudix family protein 304237..304884 Francisella tularensis subsp. holarctica OSU18 4307626 YP_762963.1 CDS arsC1 NC_008369.1 304902 305255 D arsenate reductase 304902..305255 Francisella tularensis subsp. holarctica OSU18 4307627 YP_762964.1 CDS FTH_0317 NC_008369.1 305279 305614 R conserved in Francisella genomes; hypothetical protein complement(305279..305614) Francisella tularensis subsp. holarctica OSU18 4307628 YP_762965.1 CDS FTH_0318 NC_008369.1 305791 306036 R conserved in Francisella genomes; hypothetical protein complement(305791..306036) Francisella tularensis subsp. holarctica OSU18 4307629 YP_762966.1 CDS FTH_0319 NC_008369.1 306114 307427 R NCS2 family xanthine:uracil symporter-2 complement(306114..307427) Francisella tularensis subsp. holarctica OSU18 4307630 YP_762967.1 CDS aspD NC_008369.1 307494 309080 R catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase complement(307494..309080) Francisella tularensis subsp. holarctica OSU18 4307631 YP_762968.1 CDS FTH_0323 NC_008369.1 311989 313242 R OmpA family protein complement(311989..313242) Francisella tularensis subsp. holarctica OSU18 4307634 YP_762969.1 CDS FTH_0324 NC_008369.1 313434 313898 D cyclophilin; peptidyl-prolyl isomerase 313434..313898 Francisella tularensis subsp. holarctica OSU18 4307635 YP_762970.1 CDS ispH NC_008369.1 313879 314835 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 313879..314835 Francisella tularensis subsp. holarctica OSU18 4307636 YP_762971.1 CDS FTH_0326 NC_008369.1 314837 315199 D chorismate mutase 314837..315199 Francisella tularensis subsp. holarctica OSU18 4307637 YP_762972.1 CDS FTH_0327 NC_008369.1 315214 316029 D CDP-diglycerine-serine O-phosphatidyltransferase; CDP-alcohol phosphatidyltransferase 315214..316029 Francisella tularensis subsp. holarctica OSU18 4307638 YP_762973.1 CDS FTH_0328 NC_008369.1 316034 316240 R conserved in Francisella genomes; hypothetical protein complement(316034..316240) Francisella tularensis subsp. holarctica OSU18 4307639 YP_762974.1 CDS tolQ NC_008369.1 316410 317117 D TolQ protein 316410..317117 Francisella tularensis subsp. holarctica OSU18 4307640 YP_762975.1 CDS tolR NC_008369.1 317127 317573 D TolR protein 317127..317573 Francisella tularensis subsp. holarctica OSU18 4307641 YP_762976.1 CDS FTH_0331 NC_008369.1 317560 318471 D hypothetical protein 317560..318471 Francisella tularensis subsp. holarctica OSU18 4307642 YP_762977.1 CDS tolB NC_008369.1 318483 319790 D TolB protein 318483..319790 Francisella tularensis subsp. holarctica OSU18 4307643 YP_762978.1 CDS FTH_0333 NC_008369.1 319800 320045 D conserved in Francisella genomes; hypothetical protein 319800..320045 Francisella tularensis subsp. holarctica OSU18 4307644 YP_762979.1 CDS FTH_0334 NC_008369.1 320064 320687 D OmpA family protein 320064..320687 Francisella tularensis subsp. holarctica OSU18 4307645 YP_762980.1 CDS rimO NC_008369.1 320794 322089 D catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 320794..322089 Francisella tularensis subsp. holarctica OSU18 4307646 YP_762981.1 CDS FTH_0336 NC_008369.1 322098 322448 D GNAT family acetyltransferase 322098..322448 Francisella tularensis subsp. holarctica OSU18 4307647 YP_762982.1 CDS isftu1 NC_008369.1 322594 323474 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(322594..322923,322923..323474) Francisella tularensis subsp. holarctica OSU18 4307648 YP_762983.1 CDS FTH_0338 NC_008369.1 323446 323655 D hypothetical protein 323446..323655 Francisella tularensis subsp. holarctica OSU18 4307649 YP_762984.1 CDS FTH_0340 NC_008369.1 325135 326664 D deoxyribodipyrimidine photo-lyase family protein 325135..326664 Francisella tularensis subsp. holarctica OSU18 4307651 YP_762985.1 CDS FTH_0341 NC_008369.1 326661 326798 D hypothetical protein 326661..326798 Francisella tularensis subsp. holarctica OSU18 4307652 YP_762986.1 CDS FTH_0342 NC_008369.1 326924 327856 D BASS family bile acid:sodium (Na+) symporter 326924..327856 Francisella tularensis subsp. holarctica OSU18 4307653 YP_762987.1 CDS FTH_0345 NC_008369.1 329844 330830 D hypothetical protein 329844..330830 Francisella tularensis subsp. holarctica OSU18 4307657 YP_762988.1 CDS FTH_0347 NC_008369.1 332218 332643 R hypothetical protein complement(332218..332643) Francisella tularensis subsp. holarctica OSU18 4307659 YP_762989.1 CDS isftu1 NC_008369.1 332615 333495 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(332615..333166,333166..333495)) Francisella tularensis subsp. holarctica OSU18 4307660 YP_762990.1 CDS FTH_0349 NC_008369.1 333613 333972 R hypothetical protein complement(333613..333972) Francisella tularensis subsp. holarctica OSU18 4307661 YP_762991.1 CDS ubiA NC_008369.1 333986 334840 R UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; 4-hydroxybenzoate polyprenyltransferase complement(333986..334840) Francisella tularensis subsp. holarctica OSU18 4307662 YP_762992.1 CDS FTH_0351 NC_008369.1 334843 335349 R chorismate lyase; 4-hydroxybenzoate synthetase complement(334843..335349) Francisella tularensis subsp. holarctica OSU18 4307663 YP_762993.1 CDS rph NC_008369.1 335448 336155 D RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 335448..336155 Francisella tularensis subsp. holarctica OSU18 4307664 YP_762994.1 CDS FTH_0353 NC_008369.1 336209 336532 R conserved in Francisella genomes; hypothetical protein complement(336209..336532) Francisella tularensis subsp. holarctica OSU18 4307665 YP_762995.1 CDS FTH_0354 NC_008369.1 336637 336888 R conserved in Francisella genomes; hypothetical protein complement(336637..336888) Francisella tularensis subsp. holarctica OSU18 4307666 YP_762996.1 CDS FTH_0355 NC_008369.1 336909 337544 R type IV pilus assembly protein complement(336909..337544) Francisella tularensis subsp. holarctica OSU18 4307667 YP_762997.1 CDS htpX NC_008369.1 337649 338725 R putative metalloprotease; heat shock protein HtpX complement(337649..338725) Francisella tularensis subsp. holarctica OSU18 4307668 YP_762998.1 CDS lemA NC_008369.1 338729 339304 R LemA-like protein complement(338729..339304) Francisella tularensis subsp. holarctica OSU18 4307669 YP_762999.1 CDS arsR NC_008369.1 344458 344823 R arsenic resistance operon repressor complement(344458..344823) Francisella tularensis subsp. holarctica OSU18 4306410 YP_763000.1 CDS FTH_0363 NC_008369.1 344966 345619 D conserved in Francisella genomes; hypothetical protein 344966..345619 Francisella tularensis subsp. holarctica OSU18 4306411 YP_763001.1 CDS FTH_0364 NC_008369.1 345631 345762 R conserved in Francisella genomes; hypothetical protein complement(345631..345762) Francisella tularensis subsp. holarctica OSU18 4306412 YP_763002.1 CDS gpsA NC_008369.1 345939 346937 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 345939..346937 Francisella tularensis subsp. holarctica OSU18 4306413 YP_763003.1 CDS FTH_0366 NC_008369.1 346938 347474 R conserved in Francisella genomes; hypothetical protein complement(346938..347474) Francisella tularensis subsp. holarctica OSU18 4306414 YP_763004.1 CDS radA NC_008369.1 347479 348849 R Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA complement(347479..348849) Francisella tularensis subsp. holarctica OSU18 4306415 YP_763005.1 CDS FTH_0368 NC_008369.1 348857 349627 R conserved in Francisella genomes; hypothetical protein complement(348857..349627) Francisella tularensis subsp. holarctica OSU18 4306416 YP_763006.1 CDS FTH_0369 NC_008369.1 349624 350223 R DedA family protein complement(349624..350223) Francisella tularensis subsp. holarctica OSU18 4306417 YP_763007.1 CDS FTH_0370 NC_008369.1 350226 351284 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(350226..351284) Francisella tularensis subsp. holarctica OSU18 4306418 YP_763008.1 CDS FTH_0371 NC_008369.1 351425 352078 R conserved in Francisella genomes; hypothetical protein complement(351425..352078) Francisella tularensis subsp. holarctica OSU18 4306419 YP_763009.1 CDS msrB NC_008369.1 352097 352609 R this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B complement(352097..352609) Francisella tularensis subsp. holarctica OSU18 4306420 YP_763010.1 CDS sodC NC_008369.1 352770 353327 D superoxide dismuate 352770..353327 Francisella tularensis subsp. holarctica OSU18 4306421 YP_763011.1 CDS FTH_0374 NC_008369.1 353331 354122 D sterol desaturase 353331..354122 Francisella tularensis subsp. holarctica OSU18 4306422 YP_763012.1 CDS FTH_0375 NC_008369.1 354097 355491 R APC family amino acid-polyamine-organocation transporter complement(354097..355491) Francisella tularensis subsp. holarctica OSU18 4306423 YP_763013.1 CDS FTH_0376 NC_008369.1 355641 356003 D mannose-6-phosphate isomerase 355641..356003 Francisella tularensis subsp. holarctica OSU18 4306424 YP_763014.1 CDS FTH_0378 NC_008369.1 357242 358432 R catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase complement(357242..358432) Francisella tularensis subsp. holarctica OSU18 4306426 YP_763015.1 CDS FTH_0379 NC_008369.1 358635 359522 D probable cobalt (Co2+), zinc (Zn2+), cadmium (Cd2+) CDF family cation diffusion facilitator; hypothetical protein 358635..359522 Francisella tularensis subsp. holarctica OSU18 4306427 YP_763016.1 CDS recN NC_008369.1 359608 361257 D ATPase involved in DNA repair; DNA repair protein RecN 359608..361257 Francisella tularensis subsp. holarctica OSU18 4306428 YP_763017.1 CDS FTH_0381 NC_008369.1 361558 361899 R hypothetical protein complement(361558..361899) Francisella tularensis subsp. holarctica OSU18 4306429 YP_763018.1 CDS FTH_0384 NC_008369.1 364021 364428 R type IV pili fiber protein complement(364021..364428) Francisella tularensis subsp. holarctica OSU18 4306432 YP_763019.1 CDS lpxE NC_008369.1 364812 365531 D lipid A 1-phosphatase 364812..365531 Francisella tularensis subsp. holarctica OSU18 4306433 YP_763020.1 CDS FTH_0386 NC_008369.1 365671 366519 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 365671..366519 Francisella tularensis subsp. holarctica OSU18 4306434 YP_763021.1 CDS purM NC_008369.1 366739 367782 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 366739..367782 Francisella tularensis subsp. holarctica OSU18 4306435 YP_763022.1 CDS purC/purD NC_008369.1 367782 370094 D phosphoribosylaminoimidazole-succinocarboxamide synthase 367782..370094 Francisella tularensis subsp. holarctica OSU18 4306436 YP_763023.1 CDS purN NC_008369.1 370098 370673 D 2-amino-N-ribosylacetamide 5'-phosphate transformylase; phosphoribosylglycinamide formyltransferase 370098..370673 Francisella tularensis subsp. holarctica OSU18 4306437 YP_763024.1 CDS purE NC_008369.1 370790 371281 D AIR carboxylase; phosphoribosylaminoimidazole carboxylase 370790..371281 Francisella tularensis subsp. holarctica OSU18 4306438 YP_763025.1 CDS purK NC_008369.1 371285 372382 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 371285..372382 Francisella tularensis subsp. holarctica OSU18 4306439 YP_763026.1 CDS FTH_0394 NC_008369.1 373819 374349 D intracellular septation protein A family protein 373819..374349 Francisella tularensis subsp. holarctica OSU18 4306442 YP_763027.1 CDS FTH_0395 NC_008369.1 374423 374674 D hypothetical protein 374423..374674 Francisella tularensis subsp. holarctica OSU18 4306443 YP_763028.1 CDS glk NC_008369.1 374663 375679 R glucose kinase; glucokinase complement(374663..375679) Francisella tularensis subsp. holarctica OSU18 4306444 YP_763029.1 CDS ubiE NC_008369.1 375773 376525 D menaquinone biosynthesis methyltransferase 375773..376525 Francisella tularensis subsp. holarctica OSU18 4306445 YP_763030.1 CDS FTH_0398 NC_008369.1 376509 377114 D hypothetical protein 376509..377114 Francisella tularensis subsp. holarctica OSU18 4306446 YP_763031.1 CDS ubiB NC_008369.1 377107 378765 D ubiquinone biosynthesis protein 377107..378765 Francisella tularensis subsp. holarctica OSU18 4306447 YP_763032.1 CDS hitA NC_008369.1 378771 379109 D HIT family histidine triad protein 378771..379109 Francisella tularensis subsp. holarctica OSU18 4306448 YP_763033.1 CDS FTH_0401 NC_008369.1 379126 379257 R conserved in Francisella genomes; hypothetical protein complement(379126..379257) Francisella tularensis subsp. holarctica OSU18 4306449 YP_763034.1 CDS FTH_0402 NC_008369.1 379624 380277 R glutamine phosphoribosylpyrophosphate amidotransferase; amidophosphoribosyltransferase complement(379624..380277) Francisella tularensis subsp. holarctica OSU18 4306450 YP_763035.1 CDS FTH_0403 NC_008369.1 380252 381082 D hypothetical protein 380252..381082 Francisella tularensis subsp. holarctica OSU18 4306451 YP_763036.1 CDS FTH_0404 NC_008369.1 381084 381959 R conserved in Francisella genomes; hypothetical protein complement(381084..381959) Francisella tularensis subsp. holarctica OSU18 4306452 YP_763037.1 CDS murB NC_008369.1 382038 382886 R UDP-GlcNAc-enoylpyruvate reductase; UDP-N-acetylenolpyruvoylglucosamine reductase complement(382038..382886) Francisella tularensis subsp. holarctica OSU18 4306453 YP_763038.1 CDS murA NC_008369.1 382894 384198 R enoylpyruvate transferase; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(382894..384198) Francisella tularensis subsp. holarctica OSU18 4306454 YP_763039.1 CDS engA NC_008369.1 384167 385564 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(384167..385564) Francisella tularensis subsp. holarctica OSU18 4306455 YP_763040.1 CDS FTH_0408 NC_008369.1 385801 386319 R conserved in Francisella genomes; hypothetical protein complement(385801..386319) Francisella tularensis subsp. holarctica OSU18 4306456 YP_763041.1 CDS FTH_0411 NC_008369.1 388053 388301 R hypothetical protein complement(388053..388301) Francisella tularensis subsp. holarctica OSU18 4306459 YP_763042.1 CDS prlC NC_008369.1 388382 390388 R M3 family oligopeptidase A complement(388382..390388) Francisella tularensis subsp. holarctica OSU18 4306460 YP_763043.1 CDS FTH_0413 NC_008369.1 390480 390851 D hypothetical protein 390480..390851 Francisella tularensis subsp. holarctica OSU18 4306461 YP_763044.1 CDS lpnA NC_008369.1 390932 391381 D 17 kDa lipoprotein TUL4 390932..391381 Francisella tularensis subsp. holarctica OSU18 4306462 YP_763045.1 CDS FTH_0416 NC_008369.1 392042 392545 D conserved in Francisella genomes; hypothetical protein 392042..392545 Francisella tularensis subsp. holarctica OSU18 4306464 YP_763046.1 CDS lpnB NC_008369.1 392578 393045 D conserved in Francisella genomes; lipoprotein 392578..393045 Francisella tularensis subsp. holarctica OSU18 4306465 YP_763047.1 CDS FTH_0418 NC_008369.1 393118 394560 D type IV pilus glycosylation protein 393118..394560 Francisella tularensis subsp. holarctica OSU18 4306466 YP_763048.1 CDS topA NC_008369.1 394614 396908 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining; maintains net negative superhelicity; DNA topoisomerase I complement(394614..396908) Francisella tularensis subsp. holarctica OSU18 4306467 YP_763049.1 CDS parA NC_008369.1 397107 397748 D chmomosome partition protein A 397107..397748 Francisella tularensis subsp. holarctica OSU18 4306468 YP_763050.1 CDS parB NC_008369.1 397741 398655 D chromosome partition protein B 397741..398655 Francisella tularensis subsp. holarctica OSU18 4306469 YP_763051.1 CDS guaA1 NC_008369.1 398669 399376 D glutamine amidotransferase 398669..399376 Francisella tularensis subsp. holarctica OSU18 4306470 YP_763052.1 CDS FTH_0423 NC_008369.1 399379 400260 D hypothetical protein 399379..400260 Francisella tularensis subsp. holarctica OSU18 4306471 YP_763053.1 CDS rrmJ NC_008369.1 400907 401527 R ribosomal large subunit methyltransferase J complement(400907..401527) Francisella tularensis subsp. holarctica OSU18 4306473 YP_763054.1 CDS FTH_0426 NC_008369.1 401685 402152 D conserved in Francisella genomes; hypothetical protein 401685..402152 Francisella tularensis subsp. holarctica OSU18 4306474 YP_763055.1 CDS lspA NC_008369.1 402147 402632 R lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase complement(402147..402632) Francisella tularensis subsp. holarctica OSU18 4306475 YP_763056.1 CDS ileS NC_008369.1 402619 405426 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase complement(402619..405426) Francisella tularensis subsp. holarctica OSU18 4306476 YP_763057.1 CDS ribF NC_008369.1 405519 406439 R flavokinase; riboflavin biosynthesis protein RibF complement(405519..406439) Francisella tularensis subsp. holarctica OSU18 4306477 YP_763058.1 CDS maeA NC_008369.1 406590 408404 D malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 406590..408404 Francisella tularensis subsp. holarctica OSU18 4306478 YP_763059.1 CDS FTH_0431 NC_008369.1 408567 410240 D conserved in Francisella genomes; hypothetical protein 408567..410240 Francisella tularensis subsp. holarctica OSU18 4306479 YP_763060.1 CDS FTH_0432 NC_008369.1 410257 411702 D conserved in Francisella genomes; hypothetical protein 410257..411702 Francisella tularensis subsp. holarctica OSU18 4306480 YP_763061.1 CDS FTH_0435 NC_008369.1 413833 414435 D hypothetical protein 413833..414435 Francisella tularensis subsp. holarctica OSU18 4306483 YP_763062.1 CDS FTH_0436 NC_008369.1 414432 415736 R major facilitator transporter complement(414432..415736) Francisella tularensis subsp. holarctica OSU18 4306484 YP_763063.1 CDS metG NC_008369.1 415672 417696 R methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase complement(415672..417696) Francisella tularensis subsp. holarctica OSU18 4306485 YP_763064.1 CDS FTH_0438 NC_008369.1 418266 418802 R hypothetical protein complement(418266..418802) Francisella tularensis subsp. holarctica OSU18 4306488 YP_763065.1 CDS FTH_0439 NC_008369.1 424390 424479 D hypothetical protein 424390..424479 Francisella tularensis subsp. holarctica OSU18 4306494 YP_763066.1 CDS FTH_0441 NC_008369.1 425572 426480 R hypothetical protein complement(425572..426480) Francisella tularensis subsp. holarctica OSU18 4306496 YP_763067.1 CDS FTH_0442 NC_008369.1 426745 427401 R M50 family peptidase complement(426745..427401) Francisella tularensis subsp. holarctica OSU18 4306497 YP_763068.1 CDS FTH_0443 NC_008369.1 427463 427612 D hypothetical protein 427463..427612 Francisella tularensis subsp. holarctica OSU18 4306498 YP_763069.1 CDS FTH_0444 NC_008369.1 427609 427782 D hypothetical protein 427609..427782 Francisella tularensis subsp. holarctica OSU18 4306499 YP_763070.1 CDS FTH_0445 NC_008369.1 428200 428319 D hypothetical protein 428200..428319 Francisella tularensis subsp. holarctica OSU18 4306500 YP_763071.1 CDS FTH_0446 NC_008369.1 428606 428941 D conserved in Francisella genomes; hypothetical protein 428606..428941 Francisella tularensis subsp. holarctica OSU18 4306501 YP_763072.1 CDS psd NC_008369.1 428914 429765 R catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase complement(428914..429765) Francisella tularensis subsp. holarctica OSU18 4306502 YP_763073.1 CDS FTH_0448 NC_008369.1 429865 430845 D conserved in Francisella genomes; hypothetical protein 429865..430845 Francisella tularensis subsp. holarctica OSU18 4306503 YP_763074.1 CDS FTH_0449 NC_008369.1 430854 431897 D NadM-Nudix subfamily; involved in creation of nicotanimide adenine dinucleotide NAD from either biosynthetic or salvage pathways; bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase 430854..431897 Francisella tularensis subsp. holarctica OSU18 4306504 YP_763075.1 CDS glmU NC_008369.1 431911 433278 D N-acetylglucosamine-1-phosphate uridyltransferase; UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase 431911..433278 Francisella tularensis subsp. holarctica OSU18 4306505 YP_763076.1 CDS glmS NC_008369.1 433299 435137 D Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 433299..435137 Francisella tularensis subsp. holarctica OSU18 4306506 YP_763077.1 CDS FTH_0452 NC_008369.1 435221 435742 D acetyltransferase 435221..435742 Francisella tularensis subsp. holarctica OSU18 4306507 YP_763078.1 CDS rpsU NC_008369.1 435739 435936 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(435739..435936) Francisella tularensis subsp. holarctica OSU18 4306508 YP_763079.1 CDS cspC NC_008369.1 435936 436139 R cold shock protein complement(435936..436139) Francisella tularensis subsp. holarctica OSU18 4306509 YP_763080.1 CDS FTH_0455 NC_008369.1 436387 436716 R hypothetical protein complement(436387..436716) Francisella tularensis subsp. holarctica OSU18 4306510 YP_763081.1 CDS map NC_008369.1 436843 437613 D methionine aminopeptidase 436843..437613 Francisella tularensis subsp. holarctica OSU18 4306511 YP_763082.1 CDS FTH_0457 NC_008369.1 437615 438463 D conserved in Francisella genomes; hypothetical protein 437615..438463 Francisella tularensis subsp. holarctica OSU18 4306512 YP_763083.1 CDS FTH_0458 NC_008369.1 438557 439222 D hypothetical protein 438557..439222 Francisella tularensis subsp. holarctica OSU18 4306513 YP_763084.1 CDS parC NC_008369.1 439355 441580 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 439355..441580 Francisella tularensis subsp. holarctica OSU18 4306514 YP_763085.1 CDS FTH_0460 NC_008369.1 441580 442266 D enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 441580..442266 Francisella tularensis subsp. holarctica OSU18 4306515 YP_763086.1 CDS FTH_0461 NC_008369.1 442253 442852 R conserved in Francisella genomes; hypothetical protein complement(442253..442852) Francisella tularensis subsp. holarctica OSU18 4306516 YP_763087.1 CDS FTH_0462 NC_008369.1 442845 443963 R BNR/Asp-box repeat-containing protein complement(442845..443963) Francisella tularensis subsp. holarctica OSU18 4306517 YP_763088.1 CDS slt NC_008369.1 444162 446138 D soluble lytic murein transglycosylase 444162..446138 Francisella tularensis subsp. holarctica OSU18 4306518 YP_763089.1 CDS FTH_0465 NC_008369.1 447265 447432 R hypothetical protein complement(447265..447432) Francisella tularensis subsp. holarctica OSU18 4306520 YP_763090.1 CDS FTH_0466 NC_008369.1 447551 447712 D hypothetical protein 447551..447712 Francisella tularensis subsp. holarctica OSU18 4306521 YP_763091.1 CDS FTH_0467 NC_008369.1 448001 448384 D hypothetical protein 448001..448384 Francisella tularensis subsp. holarctica OSU18 4306522 YP_763092.1 CDS dnaE NC_008369.1 449512 452991 D DNA nucleotidyltransferase (DNA-directed); DNA polymerase III subunit alpha 449512..452991 Francisella tularensis subsp. holarctica OSU18 4306524 YP_763093.1 CDS def1 NC_008369.1 453067 453702 D PDF; peptide deformylase 453067..453702 Francisella tularensis subsp. holarctica OSU18 4306525 YP_763094.1 CDS FTH_0471 NC_008369.1 454056 454172 R hypothetical protein complement(454056..454172) Francisella tularensis subsp. holarctica OSU18 4306527 YP_763095.1 CDS lolC NC_008369.1 454406 455668 D lipoprotein ABC transporter ATP-binding protein 454406..455668 Francisella tularensis subsp. holarctica OSU18 4306528 YP_763096.1 CDS lolD NC_008369.1 455661 456356 D lipoprotein ABC transporter binding protein 455661..456356 Francisella tularensis subsp. holarctica OSU18 4306529 YP_763097.1 CDS cadA NC_008369.1 456473 458614 D lysine decarboxylase 456473..458614 Francisella tularensis subsp. holarctica OSU18 4306530 YP_763098.1 CDS gcvT NC_008369.1 458705 459781 D catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 458705..459781 Francisella tularensis subsp. holarctica OSU18 4306531 YP_763099.1 CDS gcvH1 NC_008369.1 459837 460220 D glycine cleavage system H protein 459837..460220 Francisella tularensis subsp. holarctica OSU18 4306532 YP_763100.1 CDS gcvP1 NC_008369.1 460285 461652 D acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein; glycine dehydrogenase subunit 1 460285..461652 Francisella tularensis subsp. holarctica OSU18 4306533 YP_763101.1 CDS gcvP2 NC_008369.1 461658 463103 D acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; glycine dehydrogenase subunit 2 461658..463103 Francisella tularensis subsp. holarctica OSU18 4306534 YP_763102.1 CDS aroE2 NC_008369.1 463223 464068 R 5-dehydroshikimate reductase; shikimate dehydrogenase complement(463223..464068) Francisella tularensis subsp. holarctica OSU18 4306535 YP_763103.1 CDS pul NC_008369.1 464094 467306 R alpha-dextrin endo-1,6-alpha-glucosidase; pullulanase complement(464094..467306) Francisella tularensis subsp. holarctica OSU18 4306536 YP_763104.1 CDS glgB NC_008369.1 467340 469262 R catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein complement(467340..469262) Francisella tularensis subsp. holarctica OSU18 4306537 YP_763105.1 CDS pgm NC_008369.1 469564 471198 D catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 469564..471198 Francisella tularensis subsp. holarctica OSU18 4306538 YP_763106.1 CDS glgC NC_008369.1 471232 472503 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 471232..472503 Francisella tularensis subsp. holarctica OSU18 4306539 YP_763107.1 CDS glgA NC_008369.1 472513 473982 D catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 472513..473982 Francisella tularensis subsp. holarctica OSU18 4306540 YP_763108.1 CDS glgP NC_008369.1 474087 476360 D amylophosphorylase; phosphorylase 474087..476360 Francisella tularensis subsp. holarctica OSU18 4306541 YP_763109.1 CDS malQ NC_008369.1 476326 477867 D amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 476326..477867 Francisella tularensis subsp. holarctica OSU18 4306542 YP_763110.1 CDS glyQ NC_008369.1 477941 478855 D glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 477941..478855 Francisella tularensis subsp. holarctica OSU18 4306543 YP_763111.1 CDS murE NC_008369.1 479047 480525 D murE synthetase; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 479047..480525 Francisella tularensis subsp. holarctica OSU18 4306544 YP_763112.1 CDS FTH_0489 NC_008369.1 480547 480942 D hypothetical protein 480547..480942 Francisella tularensis subsp. holarctica OSU18 4306545 YP_763113.1 CDS murF NC_008369.1 481295 482653 D UDP-N--acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase 481295..482653 Francisella tularensis subsp. holarctica OSU18 4306546 YP_763114.1 CDS FTH_0491 NC_008369.1 482662 483480 D conserved in Francisella genomes; hypothetical protein 482662..483480 Francisella tularensis subsp. holarctica OSU18 4306547 YP_763115.1 CDS thrC NC_008369.1 486545 487837 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 486545..487837 Francisella tularensis subsp. holarctica OSU18 4306551 YP_763116.1 CDS speH NC_008369.1 488425 488913 D S-adenosyl-L-methionine decarboxylase; adenosylmethionine decarboxylase 488425..488913 Francisella tularensis subsp. holarctica OSU18 4306553 YP_763117.1 CDS speE NC_008369.1 488913 489782 D catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 488913..489782 Francisella tularensis subsp. holarctica OSU18 4306554 YP_763118.1 CDS lpxH NC_008369.1 494218 494934 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(494218..494934) Francisella tularensis subsp. holarctica OSU18 4307594 YP_763119.1 CDS pyrE NC_008369.1 494924 495550 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(494924..495550) Francisella tularensis subsp. holarctica OSU18 4307595 YP_763120.1 CDS murC NC_008369.1 495710 497080 D UDP-N-acetylmuramate--L-alanine ligase 495710..497080 Francisella tularensis subsp. holarctica OSU18 4307596 YP_763121.1 CDS FTH_0506 NC_008369.1 497077 497733 D rRNA methyltransferase 497077..497733 Francisella tularensis subsp. holarctica OSU18 4307597 YP_763122.1 CDS isftu1 NC_008369.1 497711 498591 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(497711..498262,498262..498591)) Francisella tularensis subsp. holarctica OSU18 4307598 YP_763123.1 CDS FTH_0508 NC_008369.1 498840 499520 D conserved in Francisella genomes; hypothetical protein 498840..499520 Francisella tularensis subsp. holarctica OSU18 4307599 YP_763124.1 CDS FTH_0509 NC_008369.1 499800 500036 R transcription regulator BolA complement(499800..500036) Francisella tularensis subsp. holarctica OSU18 4307600 YP_763125.1 CDS FTH_0510 NC_008369.1 500053 500346 R conserved in Francisella genomes; hypothetical protein complement(500053..500346) Francisella tularensis subsp. holarctica OSU18 4307601 YP_763126.1 CDS FTH_0511 NC_008369.1 500346 501014 R hypothetical protein complement(500346..501014) Francisella tularensis subsp. holarctica OSU18 4307568 YP_763127.1 CDS FTH_0512 NC_008369.1 501083 501616 R organic solvent ABC superfamily substrate-binding protein complement(501083..501616) Francisella tularensis subsp. holarctica OSU18 4307569 YP_763128.1 CDS FTH_0513 NC_008369.1 501616 502380 R toluene ABC transporter ATP-binding/membrane protein complement(501616..502380) Francisella tularensis subsp. holarctica OSU18 4307570 YP_763129.1 CDS FTH_0514 NC_008369.1 502384 503187 R ABC transporter ATP-binding protein complement(502384..503187) Francisella tularensis subsp. holarctica OSU18 4307571 YP_763130.1 CDS minE NC_008369.1 503201 503473 R works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE complement(503201..503473) Francisella tularensis subsp. holarctica OSU18 4307572 YP_763131.1 CDS minD NC_008369.1 503476 504300 R septum site-determining protein MinD complement(503476..504300) Francisella tularensis subsp. holarctica OSU18 4307573 YP_763132.1 CDS minC NC_008369.1 504340 505026 R septum site-determining protein MinC complement(504340..505026) Francisella tularensis subsp. holarctica OSU18 4307574 YP_763133.1 CDS rpmG NC_008369.1 505061 505216 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(505061..505216) Francisella tularensis subsp. holarctica OSU18 4307575 YP_763134.1 CDS rpmB NC_008369.1 505243 505479 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(505243..505479) Francisella tularensis subsp. holarctica OSU18 4307576 YP_763135.1 CDS FTH_0520 NC_008369.1 505613 505957 R conserved in Francisella genomes; hypothetical protein complement(505613..505957) Francisella tularensis subsp. holarctica OSU18 4307577 YP_763136.1 CDS recG NC_008369.1 506087 508126 D ATP-dependent DNA helicase RecG 506087..508126 Francisella tularensis subsp. holarctica OSU18 4307578 YP_763137.1 CDS FTH_0522 NC_008369.1 508130 508327 D hypothetical protein 508130..508327 Francisella tularensis subsp. holarctica OSU18 4307579 YP_763138.1 CDS FTH_0523 NC_008369.1 508573 508674 D hypothetical protein 508573..508674 Francisella tularensis subsp. holarctica OSU18 4307580 YP_763139.1 CDS fumA NC_008369.1 508881 510395 D fumarase; fumerate hydratase 508881..510395 Francisella tularensis subsp. holarctica OSU18 4307581 YP_763140.1 CDS FTH_0525 NC_008369.1 510399 510539 D hypothetical protein 510399..510539 Francisella tularensis subsp. holarctica OSU18 4307582 YP_763141.1 CDS FTH_0529 NC_008369.1 511603 511887 D exci/endonuclease 511603..511887 Francisella tularensis subsp. holarctica OSU18 4307586 YP_763142.1 CDS res NC_008369.1 512125 514998 D type III restriction enzyme; type III site-specific deoxyribonuclease 512125..514998 Francisella tularensis subsp. holarctica OSU18 4307588 YP_763143.1 CDS ung NC_008369.1 514995 515657 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 514995..515657 Francisella tularensis subsp. holarctica OSU18 4307589 YP_763144.1 CDS FTH_0534 NC_008369.1 516809 517354 R conserved in Francisella genomes; hypothetical protein complement(516809..517354) Francisella tularensis subsp. holarctica OSU18 4307943 YP_763145.1 CDS gyrA NC_008369.1 517613 520219 D DNA gyrase; DNA gyrase subunit A 517613..520219 Francisella tularensis subsp. holarctica OSU18 4307944 YP_763146.1 CDS dxr NC_008369.1 520225 521385 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 520225..521385 Francisella tularensis subsp. holarctica OSU18 4307945 YP_763147.1 CDS FTH_0537 NC_008369.1 521391 523769 D outer membrane protein/protective antigen 521391..523769 Francisella tularensis subsp. holarctica OSU18 4307946 YP_763148.1 CDS FTH_0538 NC_008369.1 523905 524408 D outer membrane protein OmpH 523905..524408 Francisella tularensis subsp. holarctica OSU18 4307947 YP_763149.1 CDS lpxD NC_008369.1 524427 525440 D adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 524427..525440 Francisella tularensis subsp. holarctica OSU18 4307948 YP_763150.1 CDS fabZ NC_008369.1 525455 525946 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 525455..525946 Francisella tularensis subsp. holarctica OSU18 4307949 YP_763151.1 CDS lpxA NC_008369.1 525949 526728 D catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 525949..526728 Francisella tularensis subsp. holarctica OSU18 4307950 YP_763152.1 CDS lpxB NC_008369.1 526728 527870 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 526728..527870 Francisella tularensis subsp. holarctica OSU18 4307951 YP_763153.1 CDS FTH_0543 NC_008369.1 527929 528516 D conserved in Francisella genomes; hypothetical protein 527929..528516 Francisella tularensis subsp. holarctica OSU18 4307952 YP_763154.1 CDS FTH_0544 NC_008369.1 528607 528981 D hypothetical protein 528607..528981 Francisella tularensis subsp. holarctica OSU18 4307953 YP_763155.1 CDS FTH_0545 NC_008369.1 529388 530431 D glycosyl hydrolase 529388..530431 Francisella tularensis subsp. holarctica OSU18 4307954 YP_763156.1 CDS FTH_0546 NC_008369.1 530802 531611 R hypothetical protein complement(530802..531611) Francisella tularensis subsp. holarctica OSU18 4307956 YP_763157.1 CDS pcs NC_008369.1 531681 532445 R CDP-diglyceride-choline O-phosphatidyltransferase; phosphatidylcholine synthase complement(531681..532445) Francisella tularensis subsp. holarctica OSU18 4307957 YP_763158.1 CDS ispA NC_008369.1 532493 533374 R farnesyl diphosphate synthetase; geranyltranstransferase complement(532493..533374) Francisella tularensis subsp. holarctica OSU18 4307958 YP_763159.1 CDS waaA NC_008369.1 533371 534666 R 3-deoxy-D-manno-octulosonic-acid transferase KdtA; 3-deoxy-D-manno-octulosonic-acid transferase complement(533371..534666) Francisella tularensis subsp. holarctica OSU18 4307959 YP_763160.1 CDS FTH_0550 NC_008369.1 534771 535349 R HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase complement(534771..535349) Francisella tularensis subsp. holarctica OSU18 4307960 YP_763161.1 CDS proC NC_008369.1 535456 536280 D P5CR; pyrroline-5-carboxylate reductase 535456..536280 Francisella tularensis subsp. holarctica OSU18 4307961 YP_763162.1 CDS FTH_0553 NC_008369.1 538038 538724 D two-component response regulator 538038..538724 Francisella tularensis subsp. holarctica OSU18 4307963 YP_763163.1 CDS lepB NC_008369.1 538729 539592 D bacterial leader peptidase I; signal peptidase I 538729..539592 Francisella tularensis subsp. holarctica OSU18 4307964 YP_763164.1 CDS rnc NC_008369.1 539599 540291 D cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 539599..540291 Francisella tularensis subsp. holarctica OSU18 4307965 YP_763165.1 CDS truB NC_008369.1 540278 541186 D catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 540278..541186 Francisella tularensis subsp. holarctica OSU18 4307966 YP_763166.1 CDS rnr NC_008369.1 541179 543431 D VacB; ribonuclease R 541179..543431 Francisella tularensis subsp. holarctica OSU18 4307967 YP_763167.1 CDS FTH_0559 NC_008369.1 544342 545085 R oxidoreductase complement(544342..545085) Francisella tularensis subsp. holarctica OSU18 4307969 YP_763168.1 CDS FTH_0560 NC_008369.1 545087 545629 R hypothetical protein complement(545087..545629) Francisella tularensis subsp. holarctica OSU18 4307970 YP_763169.1 CDS FTH_0561 NC_008369.1 545626 546171 R hypothetical protein complement(545626..546171) Francisella tularensis subsp. holarctica OSU18 4307971 YP_763170.1 CDS cfa NC_008369.1 546128 547222 R CFA synthase; cyclopropane-fatty-acyl-phospholipid synthase complement(546128..547222) Francisella tularensis subsp. holarctica OSU18 4307972 YP_763171.1 CDS FTH_0563 NC_008369.1 547409 547591 R hypothetical protein complement(547409..547591) Francisella tularensis subsp. holarctica OSU18 4307973 YP_763172.1 CDS FTH_0564 NC_008369.1 547678 548184 R hypothetical protein complement(547678..548184) Francisella tularensis subsp. holarctica OSU18 4307974 YP_763173.1 CDS FTH_0565 NC_008369.1 548178 549233 R oxidase complement(548178..549233) Francisella tularensis subsp. holarctica OSU18 4307975 YP_763174.1 CDS FTH_0567 NC_008369.1 550017 550358 R hypothetical protein complement(550017..550358) Francisella tularensis subsp. holarctica OSU18 4307977 YP_763175.1 CDS FTH_0570 NC_008369.1 552009 552545 D outer membrane protein 26; conserved in Francisella genomes; hypothetical protein 552009..552545 Francisella tularensis subsp. holarctica OSU18 4308073 YP_763176.1 CDS FTH_0571 NC_008369.1 552663 553064 D conserved in Francisella genomes; hypothetical protein 552663..553064 Francisella tularensis subsp. holarctica OSU18 4308074 YP_763177.1 CDS FTH_0572 NC_008369.1 553239 553847 D hypothetical protein 553239..553847 Francisella tularensis subsp. holarctica OSU18 4308075 YP_763178.1 CDS FTH_0573 NC_008369.1 553904 555334 D hypothetical protein 553904..555334 Francisella tularensis subsp. holarctica OSU18 4308076 YP_763179.1 CDS FTH_0574 NC_008369.1 555345 556328 D hypothetical protein 555345..556328 Francisella tularensis subsp. holarctica OSU18 4308077 YP_763180.1 CDS FTH_0575 NC_008369.1 556334 557728 D hypothetical protein 556334..557728 Francisella tularensis subsp. holarctica OSU18 4308078 YP_763181.1 CDS pncB NC_008369.1 560975 562390 D niacin ribonucleotidase; putative nicotinate phosphoribosyltransferase 560975..562390 Francisella tularensis subsp. holarctica OSU18 4308082 YP_763182.1 CDS FTH_0580 NC_008369.1 562475 562702 D hypothetical protein 562475..562702 Francisella tularensis subsp. holarctica OSU18 4308083 YP_763183.1 CDS FTH_0581 NC_008369.1 562852 564132 D major facilitator transporter 562852..564132 Francisella tularensis subsp. holarctica OSU18 4308084 YP_763184.1 CDS FTH_0582 NC_008369.1 564125 564613 R hypothetical protein complement(564125..564613) Francisella tularensis subsp. holarctica OSU18 4308085 YP_763185.1 CDS fadA NC_008369.1 564675 565862 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(564675..565862) Francisella tularensis subsp. holarctica OSU18 4308086 YP_763186.1 CDS fadB/acbP NC_008369.1 565875 568571 R beta-hydroxyacyl dehydrogenase; bifunctional 3-hydroxacyl-CoA dehydrogenase/acyl-CoA-binding protein complement(565875..568571) Francisella tularensis subsp. holarctica OSU18 4308087 YP_763187.2 CDS fadE NC_008369.1 568644 570884 R functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase complement(568644..570884) Francisella tularensis subsp. holarctica OSU18 4308088 YP_763188.1 CDS fadD1 NC_008369.1 570922 572610 R acyl-activating enzyme; long-chain-fatty-acid--CoA ligase complement(570922..572610) Francisella tularensis subsp. holarctica OSU18 4308089 YP_763189.1 CDS arsC2 NC_008369.1 572826 573173 D arsenate reductase 572826..573173 Francisella tularensis subsp. holarctica OSU18 4308090 YP_763190.1 CDS FTH_0588 NC_008369.1 573195 575438 D dual-cofactor-specific isocitrate dehydrogenase; isocitrate dehydrogenase 573195..575438 Francisella tularensis subsp. holarctica OSU18 4308091 YP_763191.1 CDS FTH_0589 NC_008369.1 575452 576339 D conserved in Francisella genomes; hypothetical protein 575452..576339 Francisella tularensis subsp. holarctica OSU18 4308092 YP_763192.1 CDS hrpA NC_008369.1 576359 580693 D ATP-dependent helicase HrpA 576359..580693 Francisella tularensis subsp. holarctica OSU18 4308093 YP_763193.1 CDS FTH_0592 NC_008369.1 581948 583684 D dTDP-glucose 4,6-dehydratase 581948..583684 Francisella tularensis subsp. holarctica OSU18 4308095 YP_763194.1 CDS FTH_0593 NC_008369.1 583677 584309 D galactosyltransferase 583677..584309 Francisella tularensis subsp. holarctica OSU18 4308096 YP_763195.1 CDS FTH_0594 NC_008369.1 584311 585102 D galactowaldenase; UDP-glucose 4-epimerase 584311..585102 Francisella tularensis subsp. holarctica OSU18 4308097 YP_763196.1 CDS FTH_0595 NC_008369.1 585092 586183 D galacturonosyltransferase 585092..586183 Francisella tularensis subsp. holarctica OSU18 4308098 YP_763197.1 CDS wecC NC_008369.1 586201 587511 D UDP-N-acetyl-D-mannosaminuronate dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase 586201..587511 Francisella tularensis subsp. holarctica OSU18 4308099 YP_763198.1 CDS FTH_0597 NC_008369.1 587499 588482 D galactowaldenase; UDP-glucose 4-epimerase 587499..588482 Francisella tularensis subsp. holarctica OSU18 4308100 YP_763199.1 CDS wzy NC_008369.1 588499 589728 D O-antigen polymerase 588499..589728 Francisella tularensis subsp. holarctica OSU18 4308101 YP_763200.1 CDS FTH_0599 NC_008369.1 589725 590825 D glycosyltransferase 589725..590825 Francisella tularensis subsp. holarctica OSU18 4308102 YP_763201.1 CDS asnB NC_008369.1 590825 592711 D asparagine synthetase (glutamine-hydrolyzing); asparagine synthase 590825..592711 Francisella tularensis subsp. holarctica OSU18 4308103 YP_763202.1 CDS wecE NC_008369.1 592704 593786 D pyridoxal phosphate-dependent sugar transaminase; ECA biosynthesis protein 592704..593786 Francisella tularensis subsp. holarctica OSU18 4308104 YP_763203.1 CDS FTH_0602 NC_008369.1 593783 594508 D hypothetical protein 593783..594508 Francisella tularensis subsp. holarctica OSU18 4308105 YP_763204.1 CDS FTH_0603 NC_008369.1 594513 596000 D O-antigen transporter; PST family polysaccharide transporter 594513..596000 Francisella tularensis subsp. holarctica OSU18 4308106 YP_763205.1 CDS FTH_0604 NC_008369.1 595993 596853 D glycosyltransferase 595993..596853 Francisella tularensis subsp. holarctica OSU18 4308107 YP_763206.1 CDS FTH_0605 NC_008369.1 596878 597762 D dTDP-glucose diphosphorylase; glucose-1-phosphate thymidylyltransferase 596878..597762 Francisella tularensis subsp. holarctica OSU18 4308108 YP_763207.1 CDS manC NC_008369.1 600574 601980 D GDP-mannose phosphorylase; mannose-1-phosphate guanylyltransferase (GDP) 600574..601980 Francisella tularensis subsp. holarctica OSU18 4308112 YP_763208.1 CDS manB NC_008369.1 602011 603495 D phosphomannose mutase; phosphomannomutase 602011..603495 Francisella tularensis subsp. holarctica OSU18 4308113 YP_763209.1 CDS rho NC_008369.1 604588 605850 R An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho complement(604588..605850) Francisella tularensis subsp. holarctica OSU18 4308114 YP_763210.1 CDS trxA1 NC_008369.1 605893 606216 R thioredoxin complement(605893..606216) Francisella tularensis subsp. holarctica OSU18 4308115 YP_763211.1 CDS ppx NC_008369.1 606405 607340 D exopolypase; exopolyphosphatase 606405..607340 Francisella tularensis subsp. holarctica OSU18 4308116 YP_763212.1 CDS FTH_0615 NC_008369.1 608225 608341 D hypothetical protein 608225..608341 Francisella tularensis subsp. holarctica OSU18 4308118 YP_763213.1 CDS FTH_0616 NC_008369.1 608500 608685 R hypothetical protein complement(608500..608685) Francisella tularensis subsp. holarctica OSU18 4308119 YP_763214.1 CDS FTH_0617 NC_008369.1 608777 609679 D recombination factor protein RarA 608777..609679 Francisella tularensis subsp. holarctica OSU18 4308120 YP_763215.1 CDS rpoA2 NC_008369.1 609767 610720 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 609767..610720 Francisella tularensis subsp. holarctica OSU18 4308121 YP_763216.1 CDS FTH_0619 NC_008369.1 610916 611065 R hypothetical protein complement(610916..611065) Francisella tularensis subsp. holarctica OSU18 4308123 YP_763217.1 CDS FTH_0620 NC_008369.1 611339 611824 R bacterioferritin complement(611339..611824) Francisella tularensis subsp. holarctica OSU18 4308124 YP_763218.1 CDS FTH_0622 NC_008369.1 613273 613401 D hypothetical protein 613273..613401 Francisella tularensis subsp. holarctica OSU18 4308126 YP_763219.1 CDS tatD NC_008369.1 613484 614251 D magnesium (Mg2+)-dependent deoxyribonuclease 613484..614251 Francisella tularensis subsp. holarctica OSU18 4308127 YP_763220.1 CDS FTH_0624 NC_008369.1 614377 615477 D hypothetical protein 614377..615477 Francisella tularensis subsp. holarctica OSU18 4308128 YP_763221.1 CDS FTH_0626 NC_008369.1 616436 617359 D multidrug ABC transporter ATP-binding protein 616436..617359 Francisella tularensis subsp. holarctica OSU18 4308130 YP_763222.1 CDS FTH_0627 NC_008369.1 617368 618147 D multidrug ABC transporter membrane protein 617368..618147 Francisella tularensis subsp. holarctica OSU18 4308131 YP_763223.1 CDS FTH_0628 NC_008369.1 618151 619095 R glycosyl transferase family protein complement(618151..619095) Francisella tularensis subsp. holarctica OSU18 4308132 YP_763224.1 CDS ppnK NC_008369.1 619286 620176 D DPN kinase; NAD(+) kinase 619286..620176 Francisella tularensis subsp. holarctica OSU18 4308133 YP_763225.1 CDS FTH_0630 NC_008369.1 620173 620808 R homoserine/threonine resistance transporter complement(620173..620808) Francisella tularensis subsp. holarctica OSU18 4308134 YP_763226.1 CDS trmB NC_008369.1 620878 621567 D tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 620878..621567 Francisella tularensis subsp. holarctica OSU18 4308135 YP_763227.1 CDS FTH_0632 NC_008369.1 621577 622293 D hypothetical protein 621577..622293 Francisella tularensis subsp. holarctica OSU18 4308136 YP_763228.1 CDS FTH_0635 NC_008369.1 623903 624202 D transcriptional regulator 623903..624202 Francisella tularensis subsp. holarctica OSU18 4308139 YP_763229.1 CDS FTH_0636 NC_008369.1 624268 624771 D rhodanese sulfurtransferase family protein 624268..624771 Francisella tularensis subsp. holarctica OSU18 4308140 YP_763230.1 CDS FTH_0638 NC_008369.1 626530 627234 D metal-dependent hydrolase 626530..627234 Francisella tularensis subsp. holarctica OSU18 4308142 YP_763231.1 CDS FTH_0639 NC_008369.1 627236 627985 D hypothetical protein 627236..627985 Francisella tularensis subsp. holarctica OSU18 4308143 YP_763232.1 CDS FTH_0640 NC_008369.1 627978 628598 R proline hydroxylase complement(627978..628598) Francisella tularensis subsp. holarctica OSU18 4308144 YP_763233.1 CDS FTH_0641 NC_008369.1 628638 629087 R hypothetical protein complement(628638..629087) Francisella tularensis subsp. holarctica OSU18 4308145 YP_763234.1 CDS FTH_0642 NC_008369.1 629318 629818 R conserved in Francisella genomes; hypothetical protein complement(629318..629818) Francisella tularensis subsp. holarctica OSU18 4308146 YP_763235.1 CDS nusB NC_008369.1 630412 630837 D N utilization substance protein B 630412..630837 Francisella tularensis subsp. holarctica OSU18 4308148 YP_763236.1 CDS FTH_0645 NC_008369.1 630821 631606 R aminohydrolase complement(630821..631606) Francisella tularensis subsp. holarctica OSU18 4308149 YP_763237.1 CDS FTH_0646 NC_008369.1 631760 632173 D conserved in Francisella genomes; hypothetical protein 631760..632173 Francisella tularensis subsp. holarctica OSU18 4308150 YP_763238.1 CDS FTH_0647 NC_008369.1 632319 633128 R conserved in Francisella genomes; hypothetical protein complement(632319..633128) Francisella tularensis subsp. holarctica OSU18 4308151 YP_763239.1 CDS FTH_0648 NC_008369.1 633236 633718 R conserved in Francisella genomes; hypothetical protein complement(633236..633718) Francisella tularensis subsp. holarctica OSU18 4308152 YP_763240.1 CDS proS NC_008369.1 634996 636693 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(634996..636693) Francisella tularensis subsp. holarctica OSU18 4308154 YP_763241.1 CDS FTH_0652 NC_008369.1 638723 638950 R hypothetical protein complement(638723..638950) Francisella tularensis subsp. holarctica OSU18 4308156 YP_763242.1 CDS FTH_0653 NC_008369.1 638953 639087 R hypothetical protein complement(638953..639087) Francisella tularensis subsp. holarctica OSU18 4308157 YP_763243.1 CDS FTH_0654 NC_008369.1 639277 639807 R hypothetical protein complement(639277..639807) Francisella tularensis subsp. holarctica OSU18 4308158 YP_763244.1 CDS FTH_0655 NC_008369.1 639809 639979 R hypothetical protein complement(639809..639979) Francisella tularensis subsp. holarctica OSU18 4308159 YP_763245.1 CDS FTH_0656 NC_008369.1 640505 640921 D SufE family Fe-S protein 640505..640921 Francisella tularensis subsp. holarctica OSU18 4308161 YP_763246.1 CDS hemD NC_008369.1 640922 641671 D hydroxymethylbilane hydrolyase (cyclizing); uroporphyrinogen-III synthase 640922..641671 Francisella tularensis subsp. holarctica OSU18 4308162 YP_763247.1 CDS FTH_0658 NC_008369.1 641637 642722 D conserved in Francisella genomes; hypothetical protein 641637..642722 Francisella tularensis subsp. holarctica OSU18 4308163 YP_763248.1 CDS FTH_0659 NC_008369.1 642719 643876 D conserved in Francisella genomes; hypothetical protein 642719..643876 Francisella tularensis subsp. holarctica OSU18 4308164 YP_763249.1 CDS gloB NC_008369.1 643890 644648 D glyoxalase II; hydroxyacylglutathione hydrolase 643890..644648 Francisella tularensis subsp. holarctica OSU18 4308165 YP_763250.1 CDS FTH_0661 NC_008369.1 644726 645433 R conserved in Francisella genomes; hypothetical protein complement(644726..645433) Francisella tularensis subsp. holarctica OSU18 4308166 YP_763251.1 CDS feoA NC_008369.1 645542 645766 D iron (Fe2+) transport protein A 645542..645766 Francisella tularensis subsp. holarctica OSU18 4308167 YP_763252.1 CDS FTH_0663 NC_008369.1 645783 647417 D conserved in Francisella genomes; hypothetical protein 645783..647417 Francisella tularensis subsp. holarctica OSU18 4308168 YP_763253.1 CDS FTH_0664 NC_008369.1 647989 648654 R prophage repressor protein complement(647989..648654) Francisella tularensis subsp. holarctica OSU18 4308172 YP_763254.1 CDS FTH_0665 NC_008369.1 648811 649179 D conserved in Francisella genomes; hypothetical protein 648811..649179 Francisella tularensis subsp. holarctica OSU18 4308173 YP_763255.1 CDS FTH_0666 NC_008369.1 649210 650082 R hypothetical protein complement(649210..650082) Francisella tularensis subsp. holarctica OSU18 4308174 YP_763256.1 CDS gltB NC_008369.1 650259 651845 D glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase; glutamate synthase 650259..651845 Francisella tularensis subsp. holarctica OSU18 4308175 YP_763257.1 CDS recC NC_008369.1 651925 655164 D similar to Escherichia coli exonuclease V; exodeoxyribonuclease V 651925..655164 Francisella tularensis subsp. holarctica OSU18 4308176 YP_763258.1 CDS FTH_0669 NC_008369.1 655106 655678 D hypothetical protein 655106..655678 Francisella tularensis subsp. holarctica OSU18 4308177 YP_763259.1 CDS FTH_0670 NC_008369.1 655710 655805 D hypothetical protein 655710..655805 Francisella tularensis subsp. holarctica OSU18 4308178 YP_763260.1 CDS FTH_0671 NC_008369.1 655821 657272 D ATP-dependent DNA helicase 655821..657272 Francisella tularensis subsp. holarctica OSU18 4308179 YP_763261.1 CDS recB NC_008369.1 657344 660997 D similar to Escherichia coli exonuclease V; exodeoxyribonuclease V 657344..660997 Francisella tularensis subsp. holarctica OSU18 4308180 YP_763262.1 CDS recD NC_008369.1 660963 662831 D similar to Escherichia coli exonuclease V; exodeoxyribonuclease V 660963..662831 Francisella tularensis subsp. holarctica OSU18 4308181 YP_763263.1 CDS FTH_0674 NC_008369.1 662840 663610 R type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase complement(662840..663610) Francisella tularensis subsp. holarctica OSU18 4308182 YP_763264.1 CDS panD NC_008369.1 663614 663949 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(663614..663949) Francisella tularensis subsp. holarctica OSU18 4308183 YP_763265.1 CDS panC NC_008369.1 663943 664776 R pantoate activating enzyme; pantoate--beta-alanine ligase complement(663943..664776) Francisella tularensis subsp. holarctica OSU18 4308184 YP_763266.1 CDS panB NC_008369.1 664715 665581 R catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase complement(664715..665581) Francisella tularensis subsp. holarctica OSU18 4308185 YP_763267.1 CDS FTH_0678 NC_008369.1 665514 666227 R hypothetical protein complement(665514..666227) Francisella tularensis subsp. holarctica OSU18 4308186 YP_763268.1 CDS ligN NC_008369.1 666535 668571 D DNA joinase; DNA ligase 666535..668571 Francisella tularensis subsp. holarctica OSU18 4308187 YP_763269.1 CDS potC NC_008369.1 669999 670805 R polyamine ABC transporter ATP-binding protein complement(669999..670805) Francisella tularensis subsp. holarctica OSU18 4308189 YP_763270.1 CDS potB NC_008369.1 670819 671736 R polyamine ABC transporter ATP-binding protein complement(670819..671736) Francisella tularensis subsp. holarctica OSU18 4308190 YP_763271.1 CDS potA NC_008369.1 671700 672821 R polyamine ABC transporter ATP-binding protein complement(671700..672821) Francisella tularensis subsp. holarctica OSU18 4308191 YP_763272.1 CDS FTH_0686 NC_008369.1 674726 675148 R conserved in Francisella genomes; hypothetical protein complement(674726..675148) Francisella tularensis subsp. holarctica OSU18 4308194 YP_763273.1 CDS nadE NC_008369.1 675252 676001 R NAD(+) synthetase (glutamine-hydrolyzing); NAD(+) synthase complement(675252..676001) Francisella tularensis subsp. holarctica OSU18 4308195 YP_763274.1 CDS FTH_0688 NC_008369.1 676130 677602 R outer membrane efflux protein complement(676130..677602) Francisella tularensis subsp. holarctica OSU18 4308196 YP_763275.1 CDS FTH_0689 NC_008369.1 677612 678634 R multidrug resistance efflux pump complement(677612..678634) Francisella tularensis subsp. holarctica OSU18 4308197 YP_763276.1 CDS FTH_0690 NC_008369.1 678656 680185 R possible multidrug efflux transporter; major facilitator transporter complement(678656..680185) Francisella tularensis subsp. holarctica OSU18 4308198 YP_763277.1 CDS FTH_0691 NC_008369.1 680329 681177 D AraC family transcription regulator 680329..681177 Francisella tularensis subsp. holarctica OSU18 4308199 YP_763278.1 CDS caiC NC_008369.1 681165 682856 R acyl-activating enzyme; long-chain-fatty-acid--CoA ligase complement(681165..682856) Francisella tularensis subsp. holarctica OSU18 4308200 YP_763279.1 CDS FTH_0693 NC_008369.1 682964 684451 R POT family proton (H+)-dependent oligopeptide transporter complement(682964..684451) Francisella tularensis subsp. holarctica OSU18 4308201 YP_763280.1 CDS FTH_0694 NC_008369.1 684681 685409 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(684681..685409) Francisella tularensis subsp. holarctica OSU18 4308202 YP_763281.1 CDS FTH_0695 NC_008369.1 685480 686166 D hypothetical protein 685480..686166 Francisella tularensis subsp. holarctica OSU18 4308203 YP_763282.1 CDS FTH_0696 NC_008369.1 686156 686854 R conserved in Francisella genomes; hypothetical protein complement(686156..686854) Francisella tularensis subsp. holarctica OSU18 4308204 YP_763283.1 CDS FTH_0697 NC_008369.1 686859 687584 R mycobacterial cell entry protein (mce); ABC transporter ATP-binding protein complement(686859..687584) Francisella tularensis subsp. holarctica OSU18 4308205 YP_763284.1 CDS FTH_0698 NC_008369.1 687594 688355 R ABC transporter ATP-binding protein complement(687594..688355) Francisella tularensis subsp. holarctica OSU18 4308206 YP_763285.1 CDS FTH_0699 NC_008369.1 688370 689470 R ABC transporter ATP-binding protein complement(688370..689470) Francisella tularensis subsp. holarctica OSU18 4308207 YP_763286.1 CDS FTH_0700 NC_008369.1 689545 690393 R hypothetical protein complement(689545..690393) Francisella tularensis subsp. holarctica OSU18 4308208 YP_763287.1 CDS rluD NC_008369.1 690335 691333 R pseudouridine synthase; pseudouridylate synthase complement(690335..691333) Francisella tularensis subsp. holarctica OSU18 4308209 YP_763288.1 CDS FTH_0702 NC_008369.1 691421 692245 D hypothetical protein 691421..692245 Francisella tularensis subsp. holarctica OSU18 4308210 YP_763289.1 CDS FTH_0703 NC_008369.1 692322 694121 D FAD-binding protein 692322..694121 Francisella tularensis subsp. holarctica OSU18 4308211 YP_763290.1 CDS glyA NC_008369.1 695922 697175 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(695922..697175) Francisella tularensis subsp. holarctica OSU18 4308213 YP_763291.1 CDS FTH_0706 NC_008369.1 697279 697827 D hypothetical protein 697279..697827 Francisella tularensis subsp. holarctica OSU18 4308214 YP_763292.1 CDS FTH_0707 NC_008369.1 697842 699113 R conserved in Francisella genomes; hypothetical protein complement(697842..699113) Francisella tularensis subsp. holarctica OSU18 4308215 YP_763293.1 CDS FTH_0708 NC_008369.1 699299 699520 R hypothetical protein complement(699299..699520) Francisella tularensis subsp. holarctica OSU18 4308216 YP_763294.1 CDS FTH_0709 NC_008369.1 699513 700652 D conserved in Francisella genomes; hypothetical protein 699513..700652 Francisella tularensis subsp. holarctica OSU18 4308217 YP_763295.1 CDS FTH_0710 NC_008369.1 700678 701568 R glycosyltransferase complement(700678..701568) Francisella tularensis subsp. holarctica OSU18 4308218 YP_763296.1 CDS FTH_0711 NC_008369.1 701576 702664 R conserved in Francisella genomes; hypothetical protein complement(701576..702664) Francisella tularensis subsp. holarctica OSU18 4308219 YP_763297.1 CDS FTH_0712 NC_008369.1 702834 703898 D glycosyltransferase 702834..703898 Francisella tularensis subsp. holarctica OSU18 4308220 YP_763298.1 CDS FTH_0713 NC_008369.1 703975 704928 R choloylglycine family hydrolase complement(703975..704928) Francisella tularensis subsp. holarctica OSU18 4308221 YP_763299.1 CDS mesJ NC_008369.1 706625 707821 R PP-loop superfamily ATPase complement(706625..707821) Francisella tularensis subsp. holarctica OSU18 4308223 YP_763300.1 CDS serA NC_008369.1 707822 709066 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(707822..709066) Francisella tularensis subsp. holarctica OSU18 4308224 YP_763301.1 CDS thyA NC_008369.1 709069 709893 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(709069..709893) Francisella tularensis subsp. holarctica OSU18 4308225 YP_763302.1 CDS lgt NC_008369.1 709878 710684 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(709878..710684) Francisella tularensis subsp. holarctica OSU18 4308226 YP_763303.1 CDS cafA1 NC_008369.1 710699 713230 R ribonuclease E complement(710699..713230) Francisella tularensis subsp. holarctica OSU18 4308227 YP_763304.1 CDS iscS NC_008369.1 713480 714655 D cysteine desulfarase 713480..714655 Francisella tularensis subsp. holarctica OSU18 4308228 YP_763305.1 CDS FTH_0721 NC_008369.1 714648 714977 D conserved in Francisella genomes; hypothetical protein 714648..714977 Francisella tularensis subsp. holarctica OSU18 4308229 YP_763306.1 CDS recO NC_008369.1 714961 715659 D DNA repair protein RecO 714961..715659 Francisella tularensis subsp. holarctica OSU18 4308230 YP_763307.1 CDS dedA1 NC_008369.1 715735 716382 R DedA family protein complement(715735..716382) Francisella tularensis subsp. holarctica OSU18 4308231 YP_763308.1 CDS dedA2 NC_008369.1 716438 717064 R DedA family protein complement(716438..717064) Francisella tularensis subsp. holarctica OSU18 4308232 YP_763309.1 CDS FTH_0725 NC_008369.1 717071 717337 R hypothetical protein complement(717071..717337) Francisella tularensis subsp. holarctica OSU18 4308233 YP_763310.1 CDS FTH_0726 NC_008369.1 717340 717888 R 5,10-methenyltetrahydrofolate synthetase; 5-formyltetrahydrofolate cyclo-ligase complement(717340..717888) Francisella tularensis subsp. holarctica OSU18 4308234 YP_763311.1 CDS FTH_0727 NC_008369.1 718328 718864 D hypothetical protein 718328..718864 Francisella tularensis subsp. holarctica OSU18 4308235 YP_763312.1 CDS ubiH NC_008369.1 718873 720084 D 2-octaprenyl-6-methoxyphenyl hydroxylase 718873..720084 Francisella tularensis subsp. holarctica OSU18 4308236 YP_763313.1 CDS FTH_0729 NC_008369.1 720074 721309 D 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 720074..721309 Francisella tularensis subsp. holarctica OSU18 4308237 YP_763314.1 CDS FTH_0730 NC_008369.1 721331 721792 D conserved in Francisella genomes; hypothetical protein 721331..721792 Francisella tularensis subsp. holarctica OSU18 4308238 YP_763315.1 CDS queA NC_008369.1 721812 722834 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 721812..722834 Francisella tularensis subsp. holarctica OSU18 4308239 YP_763316.1 CDS FTH_0732 NC_008369.1 723469 724260 D HAD superfamily haloacid dehalogenase hydrolase 723469..724260 Francisella tularensis subsp. holarctica OSU18 4308240 YP_763317.1 CDS FTH_0733 NC_008369.1 724514 725227 R hypothetical protein complement(724514..725227) Francisella tularensis subsp. holarctica OSU18 4308241 YP_763318.1 CDS gloA NC_008369.1 725343 725726 D aldoketomutase; lactoylglutathione lyase 725343..725726 Francisella tularensis subsp. holarctica OSU18 4308242 YP_763319.1 CDS isftu1 NC_008369.1 726180 727060 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(726180..726509,726509..727060) Francisella tularensis subsp. holarctica OSU18 4308244 YP_763320.1 CDS rpiA NC_008369.1 729038 729763 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(729038..729763) Francisella tularensis subsp. holarctica OSU18 4308246 YP_763321.1 CDS FTH_0739 NC_008369.1 729714 731084 R conserved in Francisella genomes; hypothetical protein complement(729714..731084) Francisella tularensis subsp. holarctica OSU18 4308247 YP_763322.1 CDS FTH_0740 NC_008369.1 731098 731490 R conserved in Francisella genomes; hypothetical protein complement(731098..731490) Francisella tularensis subsp. holarctica OSU18 4308248 YP_763323.1 CDS gidA NC_008369.1 731502 733385 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA complement(731502..733385) Francisella tularensis subsp. holarctica OSU18 4308249 YP_763324.1 CDS FTH_0742 NC_008369.1 733528 734610 D conserved in Francisella genomes; hypothetical protein 733528..734610 Francisella tularensis subsp. holarctica OSU18 4308250 YP_763325.1 CDS FTH_0743 NC_008369.1 734597 735502 D conserved in Francisella genomes; hypothetical protein 734597..735502 Francisella tularensis subsp. holarctica OSU18 4308251 YP_763326.1 CDS FTH_0745 NC_008369.1 736528 737250 D short chain dehydrogenase 736528..737250 Francisella tularensis subsp. holarctica OSU18 4308253 YP_763327.1 CDS sbcB NC_008369.1 737384 738832 D similar to Escherichia coli exonuclease I; exodeoxyribonuclease I 737384..738832 Francisella tularensis subsp. holarctica OSU18 4308254 YP_763328.1 CDS uvrB NC_008369.1 738834 740840 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 738834..740840 Francisella tularensis subsp. holarctica OSU18 4308255 YP_763329.1 CDS FTH_0748 NC_008369.1 740844 741674 D hypothetical protein 740844..741674 Francisella tularensis subsp. holarctica OSU18 4308256 YP_763330.1 CDS murI NC_008369.1 741674 742471 D glutamate racemase 741674..742471 Francisella tularensis subsp. holarctica OSU18 4308257 YP_763331.1 CDS FTH_0750 NC_008369.1 742562 743839 D major facilitator transporter 742562..743839 Francisella tularensis subsp. holarctica OSU18 4308258 YP_763332.1 CDS FTH_0753 NC_008369.1 746372 747298 D hypothetical protein 746372..747298 Francisella tularensis subsp. holarctica OSU18 4308261 YP_763333.1 CDS FTH_0754 NC_008369.1 747315 747827 D hypothetical protein 747315..747827 Francisella tularensis subsp. holarctica OSU18 4308262 YP_763334.1 CDS FTH_0755 NC_008369.1 748009 749067 D transglutaminase 748009..749067 Francisella tularensis subsp. holarctica OSU18 4308263 YP_763335.1 CDS xseA NC_008369.1 750430 751815 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 750430..751815 Francisella tularensis subsp. holarctica OSU18 4308265 YP_763336.1 CDS FTH_0758 NC_008369.1 751799 751999 D hypothetical protein 751799..751999 Francisella tularensis subsp. holarctica OSU18 4308266 YP_763337.1 CDS FTH_0760 NC_008369.1 753612 754223 R conserved in Francisella genomes; hypothetical protein complement(753612..754223) Francisella tularensis subsp. holarctica OSU18 4308268 YP_763338.1 CDS FTH_0761 NC_008369.1 754490 755245 R TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase complement(754490..755245) Francisella tularensis subsp. holarctica OSU18 4308269 YP_763339.1 CDS smpB NC_008369.1 755246 755719 R binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein complement(755246..755719) Francisella tularensis subsp. holarctica OSU18 4308270 YP_763340.1 CDS FTH_0763 NC_008369.1 755794 756225 D hypothetical protein 755794..756225 Francisella tularensis subsp. holarctica OSU18 4306877 YP_763341.1 CDS FTH_0764 NC_008369.1 756225 756530 D hypothetical protein 756225..756530 Francisella tularensis subsp. holarctica OSU18 4306878 YP_763342.1 CDS FTH_0765 NC_008369.1 756572 757777 D glycine/D-amino acid oxidase 756572..757777 Francisella tularensis subsp. holarctica OSU18 4306879 YP_763343.1 CDS vacJ NC_008369.1 757812 758774 D lipoprotein VacJ 757812..758774 Francisella tularensis subsp. holarctica OSU18 4306880 YP_763344.1 CDS ggt NC_008369.1 758829 760634 D gamma-glutamyltranspeptidase; gamma-glutamyltransferase 758829..760634 Francisella tularensis subsp. holarctica OSU18 4306881 YP_763345.1 CDS FTH_0768 NC_008369.1 760650 761402 R hypothetical protein complement(760650..761402) Francisella tularensis subsp. holarctica OSU18 4306882 YP_763346.1 CDS typA NC_008369.1 761574 763391 R GTP binding translational elongation factor Tu and G family protein complement(761574..763391) Francisella tularensis subsp. holarctica OSU18 4306883 YP_763347.1 CDS FTH_0770 NC_008369.1 763811 765364 D conserved in Francisella genomes; hypothetical protein 763811..765364 Francisella tularensis subsp. holarctica OSU18 4306884 YP_763348.1 CDS FTH_0772 NC_008369.1 767843 768613 D conserved in Francisella genomes; hypothetical protein 767843..768613 Francisella tularensis subsp. holarctica OSU18 4306886 YP_763349.1 CDS FTH_0773 NC_008369.1 768683 768892 D conserved in Francisella genomes; hypothetical protein 768683..768892 Francisella tularensis subsp. holarctica OSU18 4306887 YP_763350.1 CDS isftu1 NC_008369.1 772124 773004 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(772124..772675,772675..773004)) Francisella tularensis subsp. holarctica OSU18 4306891 YP_763351.1 CDS FTH_0778 NC_008369.1 773234 774982 R lipoprotein complement(773234..774982) Francisella tularensis subsp. holarctica OSU18 4306892 YP_763352.1 CDS FTH_0779 NC_008369.1 775049 775921 R GTP-binding protein complement(775049..775921) Francisella tularensis subsp. holarctica OSU18 4306893 YP_763353.1 CDS nagA NC_008369.1 775984 777117 D L-glutamine amidohydrolase; N-acetylglucosamine-6-phosphate deacetylase 775984..777117 Francisella tularensis subsp. holarctica OSU18 4306894 YP_763354.1 CDS FTH_0781 NC_008369.1 777121 777759 D M22 family peptidase 777121..777759 Francisella tularensis subsp. holarctica OSU18 4306895 YP_763355.1 CDS FTH_0782 NC_008369.1 777763 778569 D glutamine amidotransferase; GMP synthase 777763..778569 Francisella tularensis subsp. holarctica OSU18 4306896 YP_763356.1 CDS aat NC_008369.1 778579 779772 D aspartate aminotransferase; aspartate transaminase 778579..779772 Francisella tularensis subsp. holarctica OSU18 4306897 YP_763357.1 CDS era NC_008369.1 779886 780779 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 779886..780779 Francisella tularensis subsp. holarctica OSU18 4306898 YP_763358.1 CDS FTH_0785 NC_008369.1 780946 781209 D conserved in Francisella genomes; hypothetical protein 780946..781209 Francisella tularensis subsp. holarctica OSU18 4306899 YP_763359.1 CDS FTH_0787 NC_008369.1 784188 784367 D hypothetical protein 784188..784367 Francisella tularensis subsp. holarctica OSU18 4306901 YP_763360.1 CDS adk NC_008369.1 784549 785205 R essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase complement(784549..785205) Francisella tularensis subsp. holarctica OSU18 4306902 YP_763361.1 CDS FTH_0789 NC_008369.1 785332 786336 D conserved in Francisella genomes; hypothetical protein 785332..786336 Francisella tularensis subsp. holarctica OSU18 4306903 YP_763362.1 CDS pilN NC_008369.1 786338 786901 D Type IV pili associated protein 786338..786901 Francisella tularensis subsp. holarctica OSU18 4306904 YP_763363.1 CDS FTH_0791 NC_008369.1 786895 787491 D type IV pilus glycosylase 786895..787491 Francisella tularensis subsp. holarctica OSU18 4306905 YP_763364.1 CDS FTH_0792 NC_008369.1 787497 788087 D type IV pilus assembly protein 787497..788087 Francisella tularensis subsp. holarctica OSU18 4306906 YP_763365.1 CDS pilQ NC_008369.1 788100 789872 D type IV pilus assembly protein 788100..789872 Francisella tularensis subsp. holarctica OSU18 4306907 YP_763366.1 CDS aroK NC_008369.1 789998 790528 D type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 789998..790528 Francisella tularensis subsp. holarctica OSU18 4306908 YP_763367.1 CDS aroB NC_008369.1 790525 791604 D catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 790525..791604 Francisella tularensis subsp. holarctica OSU18 4306909 YP_763368.1 CDS FTH_0796 NC_008369.1 791662 791787 D conserved in Francisella genomes; hypothetical protein 791662..791787 Francisella tularensis subsp. holarctica OSU18 4306910 YP_763369.1 CDS FTH_0797 NC_008369.1 791953 792336 R conserved in Francisella genomes; hypothetical protein complement(791953..792336) Francisella tularensis subsp. holarctica OSU18 4306911 YP_763370.1 CDS FTH_0798 NC_008369.1 792550 792837 D hypothetical protein 792550..792837 Francisella tularensis subsp. holarctica OSU18 4306912 YP_763371.1 CDS putA NC_008369.1 792845 796918 D proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 792845..796918 Francisella tularensis subsp. holarctica OSU18 4306913 YP_763372.1 CDS FTH_0800 NC_008369.1 797078 798586 D APC family amino acid-polyamine-organocation transporter 797078..798586 Francisella tularensis subsp. holarctica OSU18 4306914 YP_763373.1 CDS FTH_0801 NC_008369.1 798662 799846 D major facilitator transporter 798662..799846 Francisella tularensis subsp. holarctica OSU18 4306915 YP_763374.1 CDS dfp NC_008369.1 799859 801034 D bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase 799859..801034 Francisella tularensis subsp. holarctica OSU18 4306916 YP_763375.1 CDS chaB NC_008369.1 802118 802348 R cation transport regulator complement(802118..802348) Francisella tularensis subsp. holarctica OSU18 4306918 YP_763376.1 CDS FTH_0806 NC_008369.1 803407 803613 R conserved in Francisella genomes; hypothetical protein complement(803407..803613) Francisella tularensis subsp. holarctica OSU18 4306920 YP_763377.1 CDS FTH_0807 NC_008369.1 803722 804165 R hypothetical protein complement(803722..804165) Francisella tularensis subsp. holarctica OSU18 4306921 YP_763378.1 CDS FTH_0808 NC_008369.1 804251 804508 D hypothetical protein 804251..804508 Francisella tularensis subsp. holarctica OSU18 4306922 YP_763379.1 CDS FTH_0810 NC_008369.1 805426 805554 D hypothetical protein 805426..805554 Francisella tularensis subsp. holarctica OSU18 4306924 YP_763380.1 CDS hemH NC_008369.1 807886 808887 R protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase complement(807886..808887) Francisella tularensis subsp. holarctica OSU18 4306927 YP_763381.1 CDS FTH_0814 NC_008369.1 809021 809281 D conserved in Francisella genomes; hypothetical protein 809021..809281 Francisella tularensis subsp. holarctica OSU18 4306928 YP_763382.1 CDS FTH_0815 NC_008369.1 809298 809633 D conserved in Francisella genomes; hypothetical protein 809298..809633 Francisella tularensis subsp. holarctica OSU18 4306929 YP_763383.1 CDS pilC NC_008369.1 810879 812108 R Type IV pili polytopic inner membrane protein complement(810879..812108) Francisella tularensis subsp. holarctica OSU18 4306931 YP_763384.1 CDS pilB NC_008369.1 812123 813904 R type IV pilus assembly protein complement(812123..813904) Francisella tularensis subsp. holarctica OSU18 4306932 YP_763385.1 CDS glpQ NC_008369.1 814062 814814 D glycerophosphoryl diester phosphodiesterase 814062..814814 Francisella tularensis subsp. holarctica OSU18 4306933 YP_763386.1 CDS cinA NC_008369.1 814803 815546 R competence/damage inducible protein CinA complement(814803..815546) Francisella tularensis subsp. holarctica OSU18 4306934 YP_763387.1 CDS cphA NC_008369.1 815670 818492 D catalyze the formation of cyanophycin which may act to store excess nitrogen; cyanophycin synthetase 815670..818492 Francisella tularensis subsp. holarctica OSU18 4306935 YP_763388.1 CDS FTH_0822 NC_008369.1 818518 820203 D tetrahydrofolylpolyglutamate synthase 818518..820203 Francisella tularensis subsp. holarctica OSU18 4306936 YP_763389.1 CDS ispF NC_008369.1 820208 820687 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(820208..820687) Francisella tularensis subsp. holarctica OSU18 4306937 YP_763390.1 CDS FTH_0824 NC_008369.1 820700 821458 R rhodanese domain-containing protein complement(820700..821458) Francisella tularensis subsp. holarctica OSU18 4306938 YP_763391.1 CDS metIQ NC_008369.1 822715 824187 R D-methionine ABC transporter membrane/binding protein complement(822715..824187) Francisella tularensis subsp. holarctica OSU18 4306940 YP_763392.1 CDS metN NC_008369.1 824165 825217 R D-methionine ABC transporter ATP-binding protein complement(824165..825217) Francisella tularensis subsp. holarctica OSU18 4306941 YP_763393.1 CDS FTH_0828 NC_008369.1 825204 825818 R hypothetical protein complement(825204..825818) Francisella tularensis subsp. holarctica OSU18 4306942 YP_763394.1 CDS tgt NC_008369.1 828211 829314 D Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 828211..829314 Francisella tularensis subsp. holarctica OSU18 4306945 YP_763395.1 CDS FTH_0834 NC_008369.1 831189 831761 D isochorismatase hydrolase family protein 831189..831761 Francisella tularensis subsp. holarctica OSU18 4306948 YP_763396.1 CDS FTH_0835 NC_008369.1 831856 832053 D hypothetical protein 831856..832053 Francisella tularensis subsp. holarctica OSU18 4306949 YP_763397.1 CDS FTH_0836 NC_008369.1 832316 832672 D preprotein translocase subunit 832316..832672 Francisella tularensis subsp. holarctica OSU18 4306950 YP_763398.1 CDS secD NC_008369.1 832729 834666 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 832729..834666 Francisella tularensis subsp. holarctica OSU18 4306951 YP_763399.1 CDS secF NC_008369.1 834685 835629 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 834685..835629 Francisella tularensis subsp. holarctica OSU18 4306952 YP_763400.1 CDS FTH_0839 NC_008369.1 835661 836191 D conserved in Francisella genomes; hypothetical protein 835661..836191 Francisella tularensis subsp. holarctica OSU18 4306953 YP_763401.1 CDS rpoH NC_008369.1 836215 837093 D binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 836215..837093 Francisella tularensis subsp. holarctica OSU18 4306954 YP_763402.1 CDS aroA NC_008369.1 837184 838461 D 3-enol-pyruvoylshikimate-5-phosphate synthase; 3-phosphoshikimate 1-carboxyvinyltransferase 837184..838461 Francisella tularensis subsp. holarctica OSU18 4306955 YP_763403.1 CDS FTH_0842 NC_008369.1 838464 839054 D conserved in Francisella genomes; hypothetical protein 838464..839054 Francisella tularensis subsp. holarctica OSU18 4306956 YP_763404.1 CDS rnhA NC_008369.1 839029 839487 D endoribonuclease H; ribonuclease H 839029..839487 Francisella tularensis subsp. holarctica OSU18 4306957 YP_763405.1 CDS ansA NC_008369.1 839489 840526 D L-asparaginase 839489..840526 Francisella tularensis subsp. holarctica OSU18 4306958 YP_763406.1 CDS FTH_0845 NC_008369.1 840597 841283 D carbonic anhydrase 840597..841283 Francisella tularensis subsp. holarctica OSU18 4306959 YP_763407.1 CDS FTH_0846 NC_008369.1 841570 842175 R conserved in Francisella genomes; hypothetical protein complement(841570..842175) Francisella tularensis subsp. holarctica OSU18 4306960 YP_763408.1 CDS FTH_0847 NC_008369.1 842239 843111 R 1-aminocyclopropane carboxylic acid deaminase; hypothetical protein complement(842239..843111) Francisella tularensis subsp. holarctica OSU18 4306961 YP_763409.1 CDS FTH_0848 NC_008369.1 843120 843290 R rubredoxin complement(843120..843290) Francisella tularensis subsp. holarctica OSU18 4306962 YP_763410.1 CDS FTH_0851 NC_008369.1 846388 847662 R DAACS family dicarboxylate/amino acid:sodium or proton symporter complement(846388..847662) Francisella tularensis subsp. holarctica OSU18 4306965 YP_763411.1 CDS FTH_0852 NC_008369.1 847864 848892 D phosphosugar isomerase 847864..848892 Francisella tularensis subsp. holarctica OSU18 4306966 YP_763412.1 CDS FTH_0853 NC_008369.1 848917 850320 D possible sugar transporter; major facilitator transporter 848917..850320 Francisella tularensis subsp. holarctica OSU18 4306967 YP_763413.1 CDS FTH_0854 NC_008369.1 850475 850594 D conserved in Francisella genomes; hypothetical protein 850475..850594 Francisella tularensis subsp. holarctica OSU18 4306968 YP_763414.1 CDS FTH_0856 NC_008369.1 851198 852655 R conserved in Francisella genomes; hypothetical protein complement(851198..852655) Francisella tularensis subsp. holarctica OSU18 4306970 YP_763415.1 CDS ispG NC_008369.1 856076 857293 D catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 856076..857293 Francisella tularensis subsp. holarctica OSU18 4306975 YP_763416.1 CDS FTH_0862 NC_008369.1 857308 858015 D hypothetical protein 857308..858015 Francisella tularensis subsp. holarctica OSU18 4306976 YP_763417.1 CDS FTH_0863 NC_008369.1 858034 859827 D M24 family aminopeptidase 858034..859827 Francisella tularensis subsp. holarctica OSU18 4306977 YP_763418.1 CDS FTH_0864 NC_008369.1 859925 860989 D endonuclease 859925..860989 Francisella tularensis subsp. holarctica OSU18 4306978 YP_763419.1 CDS bla NC_008369.1 860980 861843 R cephalosporinase; beta-lactamase complement(860980..861843) Francisella tularensis subsp. holarctica OSU18 4306979 YP_763420.1 CDS FTH_0866 NC_008369.1 862272 863222 D hypothetical protein 862272..863222 Francisella tularensis subsp. holarctica OSU18 4306980 YP_763421.1 CDS FTH_0868 NC_008369.1 864039 865529 R apolipoprotein N-acyltransferase complement(864039..865529) Francisella tularensis subsp. holarctica OSU18 4306982 YP_763422.1 CDS FTH_0869 NC_008369.1 865529 866371 R HCC family HlyC/CorC transporter complement(865529..866371) Francisella tularensis subsp. holarctica OSU18 4306983 YP_763423.1 CDS FTH_0870 NC_008369.1 866361 866849 R hypothetical protein complement(866361..866849) Francisella tularensis subsp. holarctica OSU18 4306984 YP_763424.1 CDS phoH NC_008369.1 866842 867825 R phosphate starvation-inducible protein PhoH complement(866842..867825) Francisella tularensis subsp. holarctica OSU18 4306985 YP_763425.1 CDS miaB NC_008369.1 867829 869157 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(867829..869157) Francisella tularensis subsp. holarctica OSU18 4306986 YP_763426.1 CDS FTH_0873 NC_008369.1 869380 870054 D o-methyltransferase family protein 869380..870054 Francisella tularensis subsp. holarctica OSU18 4306987 YP_763427.1 CDS tdk NC_008369.1 870822 871415 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 870822..871415 Francisella tularensis subsp. holarctica OSU18 4306989 YP_763428.1 CDS tig NC_008369.1 872078 873394 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 872078..873394 Francisella tularensis subsp. holarctica OSU18 4306990 YP_763429.1 CDS clpP NC_008369.1 873420 874025 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 873420..874025 Francisella tularensis subsp. holarctica OSU18 4306991 YP_763430.1 CDS clpX NC_008369.1 874049 875302 D binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 874049..875302 Francisella tularensis subsp. holarctica OSU18 4306992 YP_763431.1 CDS lon NC_008369.1 875327 877651 D ATP-dependent protease La; DNA-binding, ATP-dependent protease La 875327..877651 Francisella tularensis subsp. holarctica OSU18 4306993 YP_763432.1 CDS FTH_0880 NC_008369.1 877738 878010 D histone-like protein HU form B; DNA-binding protein HU-beta 877738..878010 Francisella tularensis subsp. holarctica OSU18 4306994 YP_763433.1 CDS FTH_0881 NC_008369.1 878123 879556 D hypothetical protein 878123..879556 Francisella tularensis subsp. holarctica OSU18 4306995 YP_763434.1 CDS miaA NC_008369.1 879557 880483 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 879557..880483 Francisella tularensis subsp. holarctica OSU18 4306996 YP_763435.1 CDS hfq NC_008369.1 880594 880923 D host factor I for bacteriophage Q beta replication 880594..880923 Francisella tularensis subsp. holarctica OSU18 4306997 YP_763436.1 CDS hflX NC_008369.1 880975 882282 D protease, GTP-binding subunit 880975..882282 Francisella tularensis subsp. holarctica OSU18 4306998 YP_763437.1 CDS hflK NC_008369.1 883655 884722 D membrane protease subunit HflK 883655..884722 Francisella tularensis subsp. holarctica OSU18 4307000 YP_763438.1 CDS hflC NC_008369.1 884724 885650 D membrane protease subunit HflC 884724..885650 Francisella tularensis subsp. holarctica OSU18 4307001 YP_763439.1 CDS wzb NC_008369.1 885651 886136 D phosphotyrosine phosphatase; low molecular weight (LMW) phosphotyrosine protein phosphatase 885651..886136 Francisella tularensis subsp. holarctica OSU18 4307002 YP_763440.1 CDS engB NC_008369.1 886133 886726 D binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 886133..886726 Francisella tularensis subsp. holarctica OSU18 4307003 YP_763441.1 CDS FTH_0891 NC_008369.1 888164 888514 D conserved in Francisella genomes; hypothetical protein 888164..888514 Francisella tularensis subsp. holarctica OSU18 4307005 YP_763442.1 CDS FTH_0892 NC_008369.1 888556 888666 D conserved in Francisella genomes; hypothetical protein 888556..888666 Francisella tularensis subsp. holarctica OSU18 4307006 YP_763443.1 CDS ilvH NC_008369.1 891774 892091 D acetohydroxy acid synthetase; acetolactate synthase 891774..892091 Francisella tularensis subsp. holarctica OSU18 4307009 YP_763444.1 CDS ilvC NC_008369.1 892119 893162 D acetohydroxy acid isomeroreductase; ketol-acid reductoisomerase 892119..893162 Francisella tularensis subsp. holarctica OSU18 4307010 YP_763445.1 CDS mfd NC_008369.1 893285 896710 R superfamily II helicase; transcription-repair coupling factor complement(893285..896710) Francisella tularensis subsp. holarctica OSU18 4307011 YP_763446.1 CDS FTH_0898 NC_008369.1 896755 897441 R TEGT family gene transfer transporter complement(896755..897441) Francisella tularensis subsp. holarctica OSU18 4307012 YP_763447.1 CDS FTH_0899 NC_008369.1 897557 898816 R conserved in Francisella genomes; hypothetical protein complement(897557..898816) Francisella tularensis subsp. holarctica OSU18 4307013 YP_763448.1 CDS FTH_0900 NC_008369.1 898816 899247 R hypothetical protein complement(898816..899247) Francisella tularensis subsp. holarctica OSU18 4307014 YP_763449.1 CDS nth NC_008369.1 899228 899884 R AP endonuclease class I; DNA-(apurinic or apyrimidinic site) lyase complement(899228..899884) Francisella tularensis subsp. holarctica OSU18 4307015 YP_763450.1 CDS rnfB NC_008369.1 899877 900506 R NADH:ubiquinone oxidoreductase subunit RnfB complement(899877..900506) Francisella tularensis subsp. holarctica OSU18 4307016 YP_763451.1 CDS grxB NC_008369.1 900508 901152 R cofactor involved in the reduction of disulfides; glutaredoxin complement(900508..901152) Francisella tularensis subsp. holarctica OSU18 4307017 YP_763452.1 CDS ftnA NC_008369.1 902784 903284 R ferritin protein complement(902784..903284) Francisella tularensis subsp. holarctica OSU18 4307019 YP_763453.1 CDS lipA NC_008369.1 903490 904473 D catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 903490..904473 Francisella tularensis subsp. holarctica OSU18 4307020 YP_763454.1 CDS FTH_0907 NC_008369.1 904503 905162 D isoprenoid biosynthesis protein with amidotransferase-like domain 904503..905162 Francisella tularensis subsp. holarctica OSU18 4307021 YP_763455.1 CDS FTH_0908 NC_008369.1 905178 905924 D hypothetical protein 905178..905924 Francisella tularensis subsp. holarctica OSU18 4307022 YP_763456.1 CDS ruvC NC_008369.1 906021 906536 D endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 906021..906536 Francisella tularensis subsp. holarctica OSU18 4307023 YP_763457.1 CDS FTH_0910 NC_008369.1 906609 907808 D major facilitator transporter 906609..907808 Francisella tularensis subsp. holarctica OSU18 4307024 YP_763458.1 CDS ruvA NC_008369.1 907821 908471 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 907821..908471 Francisella tularensis subsp. holarctica OSU18 4307025 YP_763459.1 CDS rmuC NC_008369.1 908497 909912 D DNA recombination protein RmuC 908497..909912 Francisella tularensis subsp. holarctica OSU18 4307026 YP_763460.1 CDS FTH_0913 NC_008369.1 910091 910540 D conserved in Francisella genomes; hypothetical protein 910091..910540 Francisella tularensis subsp. holarctica OSU18 4307027 YP_763461.1 CDS FTH_0914 NC_008369.1 910562 910858 R transcription regulator ArsR complement(910562..910858) Francisella tularensis subsp. holarctica OSU18 4307028 YP_763462.1 CDS FTH_0916 NC_008369.1 911514 912326 D hypothetical protein 911514..912326 Francisella tularensis subsp. holarctica OSU18 4307030 YP_763463.1 CDS hdc NC_008369.1 912313 913449 R catalyzes the formation of histamine from L-histidine; histidine decarboxylase complement(912313..913449) Francisella tularensis subsp. holarctica OSU18 4307031 YP_763464.1 CDS FTH_0918 NC_008369.1 913464 914162 R class II aldolase/adducin complement(913464..914162) Francisella tularensis subsp. holarctica OSU18 4307032 YP_763465.1 CDS FTH_0919 NC_008369.1 914253 914834 R DNA methylpurine-DNA glycosylase complement(914253..914834) Francisella tularensis subsp. holarctica OSU18 4307033 YP_763466.1 CDS FTH_0920 NC_008369.1 914962 915465 D amidohydrolase 914962..915465 Francisella tularensis subsp. holarctica OSU18 4307034 YP_763467.1 CDS FTH_0921 NC_008369.1 915465 916097 D NMC family nicotinamide mononucleotide uptake permease PnuC 915465..916097 Francisella tularensis subsp. holarctica OSU18 4307035 YP_763468.1 CDS FTH_0922 NC_008369.1 916216 917391 D CPA2 family monovalent cation:proton (H+) antiporter-2 916216..917391 Francisella tularensis subsp. holarctica OSU18 4307036 YP_763469.1 CDS FTH_0923 NC_008369.1 917724 918188 R hypothetical protein complement(917724..918188) Francisella tularensis subsp. holarctica OSU18 4307037 YP_763470.1 CDS prsA NC_008369.1 922280 923248 D phosphoribosyl diphosphate synthetase; ribose-phosphate diphosphokinase 922280..923248 Francisella tularensis subsp. holarctica OSU18 4307041 YP_763471.1 CDS rplY NC_008369.1 923348 923638 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 923348..923638 Francisella tularensis subsp. holarctica OSU18 4307042 YP_763472.1 CDS FTH_0929 NC_008369.1 923734 924993 D HCC family HlyC/CorC transporter 923734..924993 Francisella tularensis subsp. holarctica OSU18 4307043 YP_763473.1 CDS FTH_0932 NC_008369.1 926592 926867 R conserved in Francisella genomes; hypothetical protein complement(926592..926867) Francisella tularensis subsp. holarctica OSU18 4307046 YP_763474.1 CDS FTH_0933 NC_008369.1 926882 927973 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(926882..927973) Francisella tularensis subsp. holarctica OSU18 4307047 YP_763475.1 CDS pth NC_008369.1 927992 928567 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(927992..928567) Francisella tularensis subsp. holarctica OSU18 4307048 YP_763476.1 CDS penP NC_008369.1 928560 929444 R cephalosporinase; beta-lactamase complement(928560..929444) Francisella tularensis subsp. holarctica OSU18 4307049 YP_763477.1 CDS FTH_0936 NC_008369.1 929453 930298 R hypothetical protein complement(929453..930298) Francisella tularensis subsp. holarctica OSU18 4307050 YP_763478.1 CDS pulO NC_008369.1 930338 931156 R prepilin peptidase complement(930338..931156) Francisella tularensis subsp. holarctica OSU18 4307051 YP_763479.1 CDS FTH_0938 NC_008369.1 931160 932575 R catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase complement(931160..932575) Francisella tularensis subsp. holarctica OSU18 4307052 YP_763480.1 CDS FTH_0940 NC_008369.1 933891 935348 R POT family proton (H+)-dependent oligopeptide transporter complement(933891..935348) Francisella tularensis subsp. holarctica OSU18 4307054 YP_763481.1 CDS hslU NC_008369.1 935444 936811 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU complement(935444..936811) Francisella tularensis subsp. holarctica OSU18 4307055 YP_763482.1 CDS hslV NC_008369.1 936819 937391 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit complement(936819..937391) Francisella tularensis subsp. holarctica OSU18 4307056 YP_763483.1 CDS FTH_0943 NC_008369.1 937562 938311 D conserved in Francisella genomes; hypothetical protein 937562..938311 Francisella tularensis subsp. holarctica OSU18 4307057 YP_763484.1 CDS lplA NC_008369.1 938314 939216 R lipoate--protein ligase A complement(938314..939216) Francisella tularensis subsp. holarctica OSU18 4307058 YP_763485.1 CDS tyrS NC_008369.1 939356 940546 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 939356..940546 Francisella tularensis subsp. holarctica OSU18 4307059 YP_763486.1 CDS FTH_0946 NC_008369.1 940543 940722 D hypothetical protein 940543..940722 Francisella tularensis subsp. holarctica OSU18 4307060 YP_763487.1 CDS isftu1 NC_008369.1 940950 941830 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(940950..941501,941501..941830)) Francisella tularensis subsp. holarctica OSU18 4307061 YP_763488.1 CDS lldA NC_008369.1 942179 943066 D cytochrome b2; L-lactate dehydrogenase (cytochrome) 942179..943066 Francisella tularensis subsp. holarctica OSU18 4307062 YP_763489.1 CDS FTH_0949 NC_008369.1 943089 943265 D pyruvate decarboxylase 943089..943265 Francisella tularensis subsp. holarctica OSU18 4307063 YP_763490.1 CDS FTH_0950 NC_008369.1 943506 944885 D FAD/FMN-dehydrogenase 943506..944885 Francisella tularensis subsp. holarctica OSU18 4307064 YP_763491.1 CDS FTH_0952 NC_008369.1 946210 947367 D iron (Fe2+)-dependent alcohol dehydrogenase 946210..947367 Francisella tularensis subsp. holarctica OSU18 4307066 YP_763492.1 CDS prmA NC_008369.1 947590 948435 D 50S ribosomal protein L11 methyltransferase 947590..948435 Francisella tularensis subsp. holarctica OSU18 4307067 YP_763493.1 CDS FTH_0954 NC_008369.1 948425 949408 D tRNA-dihydrouridine synthase 948425..949408 Francisella tularensis subsp. holarctica OSU18 4307068 YP_763494.1 CDS FTH_0955 NC_008369.1 949638 951965 D type I restriction enzyme; type I site-specific deoxyribonuclease 949638..951965 Francisella tularensis subsp. holarctica OSU18 4307069 YP_763495.1 CDS FTH_0956 NC_008369.1 952207 952593 D hypothetical protein 952207..952593 Francisella tularensis subsp. holarctica OSU18 4307070 YP_763496.1 CDS FTH_0958 NC_008369.1 953302 954417 D hypothetical protein 953302..954417 Francisella tularensis subsp. holarctica OSU18 4307072 YP_763497.1 CDS FTH_0959 NC_008369.1 954575 954712 D conserved in Francisella genomes; hypothetical protein 954575..954712 Francisella tularensis subsp. holarctica OSU18 4307073 YP_763498.1 CDS dinB NC_008369.1 954732 955781 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(954732..955781) Francisella tularensis subsp. holarctica OSU18 4307074 YP_763499.1 CDS FTH_0961 NC_008369.1 955788 956390 R DJ-1/PfpI family protein complement(955788..956390) Francisella tularensis subsp. holarctica OSU18 4307075 YP_763500.1 CDS FTH_0962 NC_008369.1 956501 957547 D ABC transporter ATP-binding protein 956501..957547 Francisella tularensis subsp. holarctica OSU18 4307076 YP_763501.1 CDS FTH_0963 NC_008369.1 957544 958776 R ribonucleotide reductase; bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta complement(957544..958776) Francisella tularensis subsp. holarctica OSU18 4307077 YP_763502.1 CDS grxA NC_008369.1 958783 959043 R glutaredoxin complement(958783..959043) Francisella tularensis subsp. holarctica OSU18 4307078 YP_763503.1 CDS nrdA NC_008369.1 959047 960819 R Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha complement(959047..960819) Francisella tularensis subsp. holarctica OSU18 4307079 YP_763504.1 CDS mdh NC_008369.1 961023 962033 R Catalyzes the reversible oxidation of malate to oxaloacetate; malate dehydrogenase complement(961023..962033) Francisella tularensis subsp. holarctica OSU18 4307080 YP_763505.1 CDS FTH_0967 NC_008369.1 962142 962657 D conserved in Francisella genomes; hypothetical protein 962142..962657 Francisella tularensis subsp. holarctica OSU18 4307081 YP_763506.1 CDS FTH_0968 NC_008369.1 962673 963308 D ubiquinone biosynthesis protein 962673..963308 Francisella tularensis subsp. holarctica OSU18 4307082 YP_763507.1 CDS FTH_0969 NC_008369.1 963317 963886 R hypothetical protein complement(963317..963886) Francisella tularensis subsp. holarctica OSU18 4307083 YP_763508.1 CDS isftu1 NC_008369.1 964509 965389 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(964509..964838,964838..965389) Francisella tularensis subsp. holarctica OSU18 4307085 YP_763509.1 CDS FTH_0972 NC_008369.1 965674 967164 R hypothetical protein complement(965674..967164) Francisella tularensis subsp. holarctica OSU18 4307086 YP_763510.1 CDS FTH_0973 NC_008369.1 967219 967818 R phosphatase complement(967219..967818) Francisella tularensis subsp. holarctica OSU18 4307087 YP_763511.1 CDS ahpC NC_008369.1 967896 968495 D peroxiredoxin 967896..968495 Francisella tularensis subsp. holarctica OSU18 4307088 YP_763512.1 CDS phnA NC_008369.1 970042 970308 D phosphonoacetate hydrolase 970042..970308 Francisella tularensis subsp. holarctica OSU18 4307090 YP_763513.1 CDS FTH_0977 NC_008369.1 970381 970596 D conserved in Francisella genomes; hypothetical protein 970381..970596 Francisella tularensis subsp. holarctica OSU18 4307091 YP_763514.1 CDS FTH_0978 NC_008369.1 970600 971211 D conserved in Francisella genomes; hypothetical protein 970600..971211 Francisella tularensis subsp. holarctica OSU18 4307092 YP_763515.1 CDS dnaQ NC_008369.1 972129 972845 D DNA nucleotidyltransferase (DNA-directed); DNA-directed DNA polymerase 972129..972845 Francisella tularensis subsp. holarctica OSU18 4307094 YP_763516.1 CDS vanY NC_008369.1 972839 973312 D D-alanyl-D-alanine carboxypeptidase 972839..973312 Francisella tularensis subsp. holarctica OSU18 4307095 YP_763517.1 CDS FTH_0982 NC_008369.1 973272 974708 D hypothetical protein 973272..974708 Francisella tularensis subsp. holarctica OSU18 4307096 YP_763518.1 CDS FTH_0983 NC_008369.1 974996 975169 D hypothetical protein 974996..975169 Francisella tularensis subsp. holarctica OSU18 4307097 YP_763519.1 CDS FTH_0987 NC_008369.1 977182 977454 D hypothetical protein 977182..977454 Francisella tularensis subsp. holarctica OSU18 4307101 YP_763520.1 CDS FTH_0988 NC_008369.1 977468 978199 D hypothetical protein 977468..978199 Francisella tularensis subsp. holarctica OSU18 4307102 YP_763521.1 CDS FTH_0989 NC_008369.1 978202 979071 R oxidative stress transcriptional regulator complement(978202..979071) Francisella tularensis subsp. holarctica OSU18 4307103 YP_763522.1 CDS FTH_0990 NC_008369.1 979169 979693 D AhpC/TSA family protein 979169..979693 Francisella tularensis subsp. holarctica OSU18 4307104 YP_763523.1 CDS FTH_0991 NC_008369.1 979696 980307 D short chain dehydrogenase 979696..980307 Francisella tularensis subsp. holarctica OSU18 4307105 YP_763524.1 CDS cmk NC_008369.1 980324 980989 R CMP kinase; cytidylate kinase complement(980324..980989) Francisella tularensis subsp. holarctica OSU18 4307106 YP_763525.1 CDS serC NC_008369.1 980976 982028 R catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase complement(980976..982028) Francisella tularensis subsp. holarctica OSU18 4307107 YP_763526.1 CDS FTH_0994 NC_008369.1 982103 982357 R hypothetical protein complement(982103..982357) Francisella tularensis subsp. holarctica OSU18 4307108 YP_763527.1 CDS isftu1 NC_008369.1 982348 983228 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(982348..982677,982677..983228) Francisella tularensis subsp. holarctica OSU18 4307109 YP_763528.1 CDS FTH_0996 NC_008369.1 983206 984261 R hypothetical protein complement(983206..984261) Francisella tularensis subsp. holarctica OSU18 4307110 YP_763529.1 CDS hemF NC_008369.1 984286 985212 R catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase complement(984286..985212) Francisella tularensis subsp. holarctica OSU18 4307111 YP_763530.1 CDS FTH_0999 NC_008369.1 986279 986632 D hypothetical protein 986279..986632 Francisella tularensis subsp. holarctica OSU18 4307113 YP_763531.1 CDS rpsF NC_008369.1 986720 987082 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 986720..987082 Francisella tularensis subsp. holarctica OSU18 4307114 YP_763532.1 CDS rpsR NC_008369.1 987098 987316 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 987098..987316 Francisella tularensis subsp. holarctica OSU18 4307115 YP_763533.1 CDS rplI NC_008369.1 987326 987790 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 987326..987790 Francisella tularensis subsp. holarctica OSU18 4307116 YP_763534.1 CDS dnaB NC_008369.1 987878 989275 D replicative DNA helicase 987878..989275 Francisella tularensis subsp. holarctica OSU18 4307117 YP_763535.1 CDS FTH_1004 NC_008369.1 989306 990418 D Fe-S-cluster oxidoreductase 989306..990418 Francisella tularensis subsp. holarctica OSU18 4307118 YP_763536.1 CDS pilF NC_008369.1 990408 991313 D type IV pilus assembly protein 990408..991313 Francisella tularensis subsp. holarctica OSU18 4307119 YP_763537.1 CDS rluB NC_008369.1 991306 992121 D pseudouridine synthase; pseudouridylate synthase 991306..992121 Francisella tularensis subsp. holarctica OSU18 4307120 YP_763538.1 CDS FTH_1007 NC_008369.1 992121 992546 D conserved in Francisella genomes; hypothetical protein 992121..992546 Francisella tularensis subsp. holarctica OSU18 4307121 YP_763539.1 CDS FTH_1008 NC_008369.1 992524 992964 D acetyl-CoA:dihydrolipoamide S-acetyltransferase; dihydrolipoyllysine-residue acetyltransferase 992524..992964 Francisella tularensis subsp. holarctica OSU18 4307122 YP_763540.1 CDS FTH_1010 NC_008369.1 994168 994311 D hypothetical protein 994168..994311 Francisella tularensis subsp. holarctica OSU18 4307124 YP_763541.1 CDS FTH_1011 NC_008369.1 994341 994478 D hypothetical protein 994341..994478 Francisella tularensis subsp. holarctica OSU18 4307125 YP_763542.1 CDS FTH_1012 NC_008369.1 994739 994945 D conserved in Francisella genomes; hypothetical protein 994739..994945 Francisella tularensis subsp. holarctica OSU18 4307126 YP_763543.1 CDS FTH_1013 NC_008369.1 995393 995545 D conserved in Francisella genomes; hypothetical protein 995393..995545 Francisella tularensis subsp. holarctica OSU18 4307127 YP_763544.1 CDS FTH_1016 NC_008369.1 998453 999019 D conserved in Francisella genomes; hypothetical protein 998453..999019 Francisella tularensis subsp. holarctica OSU18 4307130 YP_763545.1 CDS FTH_1017 NC_008369.1 999071 999436 D conserved in Francisella genomes; hypothetical protein 999071..999436 Francisella tularensis subsp. holarctica OSU18 4307131 YP_763546.1 CDS FTH_1018 NC_008369.1 1000103 1000726 D conserved in Francisella genomes; hypothetical protein 1000103..1000726 Francisella tularensis subsp. holarctica OSU18 4307132 YP_763547.1 CDS FTH_1019 NC_008369.1 1000807 1001238 D conserved in Francisella genomes; hypothetical protein 1000807..1001238 Francisella tularensis subsp. holarctica OSU18 4307133 YP_763548.1 CDS ispB NC_008369.1 1001328 1002305 D octaprenyl-diphosphate synthase 1001328..1002305 Francisella tularensis subsp. holarctica OSU18 4307134 YP_763549.1 CDS FTH_1021 NC_008369.1 1002323 1003135 R cyclophilin; peptidyl-prolyl isomerase complement(1002323..1003135) Francisella tularensis subsp. holarctica OSU18 4307135 YP_763550.1 CDS FTH_1022 NC_008369.1 1003149 1003952 R TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase complement(1003149..1003952) Francisella tularensis subsp. holarctica OSU18 4307136 YP_763551.1 CDS FTH_1023 NC_008369.1 1003945 1004361 R hypothetical protein complement(1003945..1004361) Francisella tularensis subsp. holarctica OSU18 4307137 YP_763552.1 CDS FTH_1024 NC_008369.1 1004377 1004988 R hypothetical protein complement(1004377..1004988) Francisella tularensis subsp. holarctica OSU18 4307138 YP_763553.1 CDS dacB NC_008369.1 1004989 1006392 R D-alanyl-D-alanine carboxypeptidase; serine-type D-Ala-D-Ala carboxypeptidase complement(1004989..1006392) Francisella tularensis subsp. holarctica OSU18 4307139 YP_763554.1 CDS rpsU NC_008369.1 1006648 1006845 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1006648..1006845 Francisella tularensis subsp. holarctica OSU18 4306670 YP_763555.1 CDS FTH_1027 NC_008369.1 1006906 1007352 D GatB domain-containing protein 1006906..1007352 Francisella tularensis subsp. holarctica OSU18 4306671 YP_763556.1 CDS dnaG NC_008369.1 1007373 1009190 D DNA primase 1007373..1009190 Francisella tularensis subsp. holarctica OSU18 4306672 YP_763557.1 CDS rpoD NC_008369.1 1009215 1010948 D RNA polymerase sigma-70 factor 1009215..1010948 Francisella tularensis subsp. holarctica OSU18 4306673 YP_763558.1 CDS ndh NC_008369.1 1011055 1012305 D beta-NADH dehydrogenase dinucleotide; NADH dehydrogenase 1011055..1012305 Francisella tularensis subsp. holarctica OSU18 4306674 YP_763559.1 CDS FTH_1033 NC_008369.1 1016050 1016145 D hypothetical protein 1016050..1016145 Francisella tularensis subsp. holarctica OSU18 4306677 YP_763560.1 CDS lipB NC_008369.1 1016363 1016983 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(1016363..1016983) Francisella tularensis subsp. holarctica OSU18 4306678 YP_763561.1 CDS FTH_1035 NC_008369.1 1016993 1017277 R hypothetical protein complement(1016993..1017277) Francisella tularensis subsp. holarctica OSU18 4306679 YP_763562.1 CDS FTH_1036 NC_008369.1 1017310 1018644 R D-alanyl-D-alanine carboxypeptidase; serine-type D-Ala-D-Ala carboxypeptidase complement(1017310..1018644) Francisella tularensis subsp. holarctica OSU18 4306680 YP_763563.1 CDS ppa NC_008369.1 1018801 1019322 D diphosphate phosphohydrolase; inorganic pyrophosphatase 1018801..1019322 Francisella tularensis subsp. holarctica OSU18 4306681 YP_763564.1 CDS kdsC NC_008369.1 1019413 1019961 D 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 1019413..1019961 Francisella tularensis subsp. holarctica OSU18 4306682 YP_763565.1 CDS FTH_1039 NC_008369.1 1019969 1020595 D conserved in Francisella genomes; hypothetical protein 1019969..1020595 Francisella tularensis subsp. holarctica OSU18 4306683 YP_763566.1 CDS FTH_1040 NC_008369.1 1020582 1021415 D conserved in Francisella genomes; hypothetical protein 1020582..1021415 Francisella tularensis subsp. holarctica OSU18 4306684 YP_763567.1 CDS FTH_1041 NC_008369.1 1021489 1022220 D ABC transporter ATP-binding protein 1021489..1022220 Francisella tularensis subsp. holarctica OSU18 4306685 YP_763568.1 CDS FTH_1042 NC_008369.1 1022269 1022862 D fumarylacetoacetate hydrolase family protein 1022269..1022862 Francisella tularensis subsp. holarctica OSU18 4306686 YP_763569.1 CDS FTH_1043 NC_008369.1 1022875 1024707 D bifunctional phosphorylase/lipase 1022875..1024707 Francisella tularensis subsp. holarctica OSU18 4306687 YP_763570.1 CDS truA NC_008369.1 1024710 1025486 D mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1024710..1025486 Francisella tularensis subsp. holarctica OSU18 4306688 YP_763571.1 CDS guaA NC_008369.1 1027173 1028723 D contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1027173..1028723 Francisella tularensis subsp. holarctica OSU18 4306690 YP_763572.1 CDS dxs NC_008369.1 1028805 1030652 D catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1028805..1030652 Francisella tularensis subsp. holarctica OSU18 4306691 YP_763573.1 CDS FTH_1048 NC_008369.1 1030668 1031003 D hypothetical protein 1030668..1031003 Francisella tularensis subsp. holarctica OSU18 4306692 YP_763574.1 CDS FTH_1049 NC_008369.1 1031025 1031654 D lipase 1031025..1031654 Francisella tularensis subsp. holarctica OSU18 4306693 YP_763575.1 CDS FTH_1050 NC_008369.1 1031664 1032254 R hypothetical protein complement(1031664..1032254) Francisella tularensis subsp. holarctica OSU18 4306694 YP_763576.1 CDS FTH_1051 NC_008369.1 1032372 1033097 D short chain dehydrogenase family protein 1032372..1033097 Francisella tularensis subsp. holarctica OSU18 4306695 YP_763577.1 CDS ruvB NC_008369.1 1033161 1034207 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1033161..1034207 Francisella tularensis subsp. holarctica OSU18 4306696 YP_763578.1 CDS FTH_1054 NC_008369.1 1035190 1035378 R hypothetical protein complement(1035190..1035378) Francisella tularensis subsp. holarctica OSU18 4306698 YP_763579.1 CDS FTH_1055 NC_008369.1 1035490 1035693 R transcriptional regulator complement(1035490..1035693) Francisella tularensis subsp. holarctica OSU18 4306699 YP_763580.1 CDS FTH_1057 NC_008369.1 1036371 1036499 D conserved in Francisella genomes; hypothetical protein 1036371..1036499 Francisella tularensis subsp. holarctica OSU18 4306701 YP_763581.1 CDS FTH_1060 NC_008369.1 1038548 1038733 D hypothetical protein 1038548..1038733 Francisella tularensis subsp. holarctica OSU18 4306704 YP_763582.1 CDS FTH_1061 NC_008369.1 1038756 1038887 D hypothetical protein 1038756..1038887 Francisella tularensis subsp. holarctica OSU18 4306705 YP_763583.1 CDS FTH_1064 NC_008369.1 1040380 1040733 R hypothetical protein complement(1040380..1040733) Francisella tularensis subsp. holarctica OSU18 4306708 YP_763584.1 CDS spoU NC_008369.1 1041960 1042712 R rRNA methyltransferase complement(1041960..1042712) Francisella tularensis subsp. holarctica OSU18 4306710 YP_763585.1 CDS tspO NC_008369.1 1044801 1045277 R tryptophan-rich sensory protein complement(1044801..1045277) Francisella tularensis subsp. holarctica OSU18 4306712 YP_763586.1 CDS msrA1 NC_008369.1 1045406 1046260 D this fusion consists of methionine sulfoxide B reductase at the N-terminus and A at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion protein of these enzymes with thioredoxin provides protection against oxidative stress in Neisseria gonorrhoeae; bifunctional methionine sulfoxide reductase B/A protein 1045406..1046260 Francisella tularensis subsp. holarctica OSU18 4306713 YP_763587.1 CDS FTH_1071 NC_008369.1 1047720 1048841 R thioredoxin family protein complement(1047720..1048841) Francisella tularensis subsp. holarctica OSU18 4306715 YP_763588.1 CDS FTH_1074 NC_008369.1 1050329 1050736 R hypothetical protein complement(1050329..1050736) Francisella tularensis subsp. holarctica OSU18 4306718 YP_763589.1 CDS FTH_1075 NC_008369.1 1050809 1051102 D conserved in Francisella genomes; hypothetical protein 1050809..1051102 Francisella tularensis subsp. holarctica OSU18 4306719 YP_763590.1 CDS FTH_1076 NC_008369.1 1051129 1051461 D hypothetical protein 1051129..1051461 Francisella tularensis subsp. holarctica OSU18 4306720 YP_763591.1 CDS FTH_1078 NC_008369.1 1053011 1053457 R conserved in Francisella genomes; hypothetical protein complement(1053011..1053457) Francisella tularensis subsp. holarctica OSU18 4306722 YP_763592.1 CDS alaS NC_008369.1 1053613 1056210 D Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1053613..1056210 Francisella tularensis subsp. holarctica OSU18 4306723 YP_763593.1 CDS FTH_1080 NC_008369.1 1056218 1057600 D outer membrane protein TolC 1056218..1057600 Francisella tularensis subsp. holarctica OSU18 4306724 YP_763594.1 CDS FTH_1081 NC_008369.1 1057603 1058982 D cytosol aminopeptidase; leucyl aminopeptidase 1057603..1058982 Francisella tularensis subsp. holarctica OSU18 4306725 YP_763595.1 CDS talA NC_008369.1 1059062 1060081 D dihydroxyacetone transferase; transaldolase B 1059062..1060081 Francisella tularensis subsp. holarctica OSU18 4306726 YP_763596.1 CDS FTH_1086 NC_008369.1 1062136 1062771 R NMC family nicotinamide mononucleotide uptake permease PnuC complement(1062136..1062771) Francisella tularensis subsp. holarctica OSU18 4306730 YP_763597.1 CDS FTH_1087 NC_008369.1 1062811 1063332 R nicotinamidase complement(1062811..1063332) Francisella tularensis subsp. holarctica OSU18 4306731 YP_763598.1 CDS FTH_1088 NC_008369.1 1063940 1064686 D hypothetical protein 1063940..1064686 Francisella tularensis subsp. holarctica OSU18 4306732 YP_763599.1 CDS uvrD1 NC_008369.1 1064680 1066695 D ATP-dependent DNA helicase 1064680..1066695 Francisella tularensis subsp. holarctica OSU18 4306733 YP_763600.1 CDS FTH_1090 NC_008369.1 1066751 1067581 D hypothetical protein 1066751..1067581 Francisella tularensis subsp. holarctica OSU18 4306734 YP_763601.1 CDS FTH_1091 NC_008369.1 1067712 1068698 R rhodanese sulfurtransferase complement(1067712..1068698) Francisella tularensis subsp. holarctica OSU18 4306735 YP_763602.1 CDS rdgC NC_008369.1 1068892 1069752 D Required for efficient pilin antigenic variation; recombination associated protein 1068892..1069752 Francisella tularensis subsp. holarctica OSU18 4306736 YP_763603.1 CDS FTH_1093 NC_008369.1 1069757 1070014 D conserved in Francisella genomes; hypothetical protein 1069757..1070014 Francisella tularensis subsp. holarctica OSU18 4306737 YP_763604.1 CDS FTH_1094 NC_008369.1 1070030 1070452 R hypothetical protein complement(1070030..1070452) Francisella tularensis subsp. holarctica OSU18 4306738 YP_763605.1 CDS FTH_1095 NC_008369.1 1070678 1071481 D hypothetical protein 1070678..1071481 Francisella tularensis subsp. holarctica OSU18 4306739 YP_763606.1 CDS FTH_1097 NC_008369.1 1072648 1073463 D hypothetical protein 1072648..1073463 Francisella tularensis subsp. holarctica OSU18 4306741 YP_763607.1 CDS FTH_1098 NC_008369.1 1073444 1073830 D hypothetical protein 1073444..1073830 Francisella tularensis subsp. holarctica OSU18 4306742 YP_763608.1 CDS hipA NC_008369.1 1073954 1075228 R transcriptional regulator complement(1073954..1075228) Francisella tularensis subsp. holarctica OSU18 4306743 YP_763609.1 CDS FTH_1100 NC_008369.1 1075213 1075440 R transcriptional regulator complement(1075213..1075440) Francisella tularensis subsp. holarctica OSU18 4306744 YP_763610.1 CDS FTH_1101 NC_008369.1 1075705 1075914 D hypothetical protein 1075705..1075914 Francisella tularensis subsp. holarctica OSU18 4306745 YP_763611.1 CDS FTH_1102 NC_008369.1 1076138 1076227 D hypothetical protein 1076138..1076227 Francisella tularensis subsp. holarctica OSU18 4306746 YP_763612.1 CDS isftu1 NC_008369.1 1076228 1077108 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(1076228..1076779,1076779..1077108)) Francisella tularensis subsp. holarctica OSU18 4306747 YP_763613.1 CDS FTH_1104 NC_008369.1 1077099 1077368 D hypothetical protein 1077099..1077368 Francisella tularensis subsp. holarctica OSU18 4306748 YP_763614.1 CDS FTH_1105 NC_008369.1 1077461 1077952 D acetyltransferase 1077461..1077952 Francisella tularensis subsp. holarctica OSU18 4306749 YP_763615.1 CDS suhB NC_008369.1 1079210 1079998 R inositol 1-phosphatase; inositol-phosphate phosphatase complement(1079210..1079998) Francisella tularensis subsp. holarctica OSU18 4306751 YP_763616.1 CDS FTH_1108 NC_008369.1 1080085 1081137 R hypothetical protein complement(1080085..1081137) Francisella tularensis subsp. holarctica OSU18 4306752 YP_763617.1 CDS FTH_1109 NC_008369.1 1081227 1082435 R hypothetical protein complement(1081227..1082435) Francisella tularensis subsp. holarctica OSU18 4306753 YP_763618.1 CDS FTH_1111 NC_008369.1 1083233 1083547 R hypothetical protein complement(1083233..1083547) Francisella tularensis subsp. holarctica OSU18 4306755 YP_763619.1 CDS fabF NC_008369.1 1083598 1084857 R beta-ketoacyl-ACP synthase; 3-oxoacyl-ACP synthase complement(1083598..1084857) Francisella tularensis subsp. holarctica OSU18 4306756 YP_763620.1 CDS acpP NC_008369.1 1084937 1085275 R carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein complement(1084937..1085275) Francisella tularensis subsp. holarctica OSU18 4306757 YP_763621.1 CDS fabG NC_008369.1 1085318 1086061 R 3-oxoacyl-(acyl-carrier-protein) reductase complement(1085318..1086061) Francisella tularensis subsp. holarctica OSU18 4306758 YP_763622.1 CDS fabD NC_008369.1 1086075 1086995 R [acyl-carrier-protein] S-malonyltransferase complement(1086075..1086995) Francisella tularensis subsp. holarctica OSU18 4306759 YP_763623.1 CDS fabH NC_008369.1 1087043 1088014 R beta-ketoacyl-ACP synthase; 3-oxoacyl-ACP synthase complement(1087043..1088014) Francisella tularensis subsp. holarctica OSU18 4306760 YP_763624.1 CDS plsX NC_008369.1 1088111 1089157 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX complement(1088111..1089157) Francisella tularensis subsp. holarctica OSU18 4306761 YP_763625.1 CDS rpmF NC_008369.1 1089256 1089438 R some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 complement(1089256..1089438) Francisella tularensis subsp. holarctica OSU18 4306762 YP_763626.1 CDS FTH_1119 NC_008369.1 1089482 1089985 R hypothetical protein complement(1089482..1089985) Francisella tularensis subsp. holarctica OSU18 4306763 YP_763627.1 CDS tktA NC_008369.1 1090124 1092115 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1090124..1092115 Francisella tularensis subsp. holarctica OSU18 4306764 YP_763628.1 CDS gapA NC_008369.1 1092096 1093154 D GAPDH; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 1092096..1093154 Francisella tularensis subsp. holarctica OSU18 4306765 YP_763629.1 CDS pgk NC_008369.1 1093173 1094351 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1093173..1094351 Francisella tularensis subsp. holarctica OSU18 4306766 YP_763630.1 CDS pykA NC_008369.1 1094367 1095803 D phosphoenol transphosphorylase; pyruvate kinase 1094367..1095803 Francisella tularensis subsp. holarctica OSU18 4306767 YP_763631.1 CDS fba NC_008369.1 1095822 1096886 D class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 1095822..1096886 Francisella tularensis subsp. holarctica OSU18 4306768 YP_763632.1 CDS iglA1 NC_008369.1 1101418 1102008 D IglA1; intracellular growth locus A protein 1101418..1102008 Francisella tularensis subsp. holarctica OSU18 4306773 YP_763633.1 CDS iglB1 NC_008369.1 1101998 1103542 D IglB1; intracellular growth locus B protein 1101998..1103542 Francisella tularensis subsp. holarctica OSU18 4306774 YP_763634.1 CDS iglC1 NC_008369.1 1103559 1104188 D IglC1; intracellular growth locus C protein 1103559..1104188 Francisella tularensis subsp. holarctica OSU18 4306775 YP_763635.1 CDS iglD1 NC_008369.1 1104200 1105405 D IglD1; intracellular growth locus D protein 1104200..1105405 Francisella tularensis subsp. holarctica OSU18 4306776 YP_763636.1 CDS FTH_1133 NC_008369.1 1105412 1105987 R conserved in Francisella genomes; hypothetical protein complement(1105412..1105987) Francisella tularensis subsp. holarctica OSU18 4306777 YP_763637.1 CDS pdpC1 NC_008369.1 1106005 1109991 R PdpC1; conserved in Francisella genomes; protein PdpC complement(1106005..1109991) Francisella tularensis subsp. holarctica OSU18 4306778 YP_763638.1 CDS FTH_1135 NC_008369.1 1110031 1110804 R conserved in Francisella genomes; hypothetical protein complement(1110031..1110804) Francisella tularensis subsp. holarctica OSU18 4306779 YP_763639.1 CDS FTH_1136 NC_008369.1 1110770 1111921 R conserved in Francisella genomes; hypothetical protein complement(1110770..1111921) Francisella tularensis subsp. holarctica OSU18 4306780 YP_763640.1 CDS FTH_1137 NC_008369.1 1111943 1112566 R conserved in Francisella genomes; hypothetical protein complement(1111943..1112566) Francisella tularensis subsp. holarctica OSU18 4306781 YP_763641.1 CDS FTH_1138 NC_008369.1 1112579 1114009 R conserved in Francisella genomes; hypothetical protein complement(1112579..1114009) Francisella tularensis subsp. holarctica OSU18 4306782 YP_763642.1 CDS FTH_1139 NC_008369.1 1114022 1114543 R hypothetical protein complement(1114022..1114543) Francisella tularensis subsp. holarctica OSU18 4306783 YP_763643.1 CDS FTH_1140 NC_008369.1 1114611 1116275 R conserved in Francisella genomes; hypothetical protein complement(1114611..1116275) Francisella tularensis subsp. holarctica OSU18 4306784 YP_763644.1 CDS FTH_1141 NC_008369.1 1116280 1116774 R conserved in Francisella genomes; hypothetical protein complement(1116280..1116774) Francisella tularensis subsp. holarctica OSU18 4306785 YP_763645.1 CDS FTH_1142 NC_008369.1 1116787 1117164 R conserved in Francisella genomes; hypothetical protein complement(1116787..1117164) Francisella tularensis subsp. holarctica OSU18 4306786 YP_763646.1 CDS pdpB1 NC_008369.1 1117154 1120435 R PdpB1; conserved in Francisella genomes; hypothetical protein complement(1117154..1120435) Francisella tularensis subsp. holarctica OSU18 4306787 YP_763647.1 CDS pdpA1 NC_008369.1 1120440 1122902 R PdpA1; conserved in Francisella genomes; hypothetical protein complement(1120440..1122902) Francisella tularensis subsp. holarctica OSU18 4306788 YP_763648.1 CDS FTH_1146 NC_008369.1 1128471 1129040 R hypothetical protein complement(1128471..1129040) Francisella tularensis subsp. holarctica OSU18 4306794 YP_763649.1 CDS FTH_1147 NC_008369.1 1129058 1129240 R hypothetical protein complement(1129058..1129240) Francisella tularensis subsp. holarctica OSU18 4306795 YP_763650.1 CDS cysK NC_008369.1 1129302 1130225 R beta-thionase; cystathionine beta-synthase complement(1129302..1130225) Francisella tularensis subsp. holarctica OSU18 4306796 YP_763651.1 CDS FTH_1151 NC_008369.1 1132553 1132747 D conserved in Francisella genomes; hypothetical protein 1132553..1132747 Francisella tularensis subsp. holarctica OSU18 4306799 YP_763652.1 CDS trmE NC_008369.1 1132757 1134109 R in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE complement(1132757..1134109) Francisella tularensis subsp. holarctica OSU18 4306800 YP_763653.1 CDS FTH_1153 NC_008369.1 1134115 1134252 R conserved in Francisella genomes; hypothetical protein complement(1134115..1134252) Francisella tularensis subsp. holarctica OSU18 4306801 YP_763654.1 CDS FTH_1154 NC_008369.1 1134290 1134382 D hypothetical protein 1134290..1134382 Francisella tularensis subsp. holarctica OSU18 4306802 YP_763655.1 CDS FTH_1155 NC_008369.1 1134479 1134775 D sigma 54 modulation protein/SE30A ribosomal protein 1134479..1134775 Francisella tularensis subsp. holarctica OSU18 4306803 YP_763656.1 CDS FTH_1156 NC_008369.1 1134812 1135267 D SSPTS family porter component IIA 1134812..1135267 Francisella tularensis subsp. holarctica OSU18 4306804 YP_763657.1 CDS lasT NC_008369.1 1135260 1136003 D rRNA methyltransferase 1135260..1136003 Francisella tularensis subsp. holarctica OSU18 4306805 YP_763658.1 CDS rnhB NC_008369.1 1136005 1136568 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1136005..1136568 Francisella tularensis subsp. holarctica OSU18 4306806 YP_763659.1 CDS FTH_1159 NC_008369.1 1136561 1137832 D SSS family solute/sodium (Na+) symporter 1136561..1137832 Francisella tularensis subsp. holarctica OSU18 4306807 YP_763660.1 CDS mglB NC_008369.1 1137829 1138236 R stringent starvation protein subunit B; ClpXP protease specificity-enhancing factor complement(1137829..1138236) Francisella tularensis subsp. holarctica OSU18 4306808 YP_763661.1 CDS mglA NC_008369.1 1138238 1138855 R stringent starvation protein subunit A; macrophage growth locus protein subunit A complement(1138238..1138855) Francisella tularensis subsp. holarctica OSU18 4306809 YP_763662.2 CDS rpsI NC_008369.1 1138915 1139304 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(1138915..1139304) Francisella tularensis subsp. holarctica OSU18 4306810 YP_763663.1 CDS rplM NC_008369.1 1139320 1139748 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(1139320..1139748) Francisella tularensis subsp. holarctica OSU18 4306811 YP_763664.1 CDS hemY NC_008369.1 1139887 1141071 R hypothetical protein complement(1139887..1141071) Francisella tularensis subsp. holarctica OSU18 4306812 YP_763665.1 CDS mltA NC_008369.1 1141064 1142230 R membrane-bound murein transglycosylase complement(1141064..1142230) Francisella tularensis subsp. holarctica OSU18 4306813 YP_763666.1 CDS grpE NC_008369.1 1142319 1142906 D with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 1142319..1142906 Francisella tularensis subsp. holarctica OSU18 4306814 YP_763667.1 CDS dnaK NC_008369.1 1143007 1144935 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 1143007..1144935 Francisella tularensis subsp. holarctica OSU18 4306815 YP_763668.1 CDS dnaJ2 NC_008369.1 1144961 1146139 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 1144961..1146139 Francisella tularensis subsp. holarctica OSU18 4306816 YP_763669.1 CDS FTH_1169 NC_008369.1 1146153 1146941 R LysR family transcriptional regulator complement(1146153..1146941) Francisella tularensis subsp. holarctica OSU18 4306817 YP_763670.1 CDS FTH_1170 NC_008369.1 1147034 1147282 D conserved in Francisella genomes; hypothetical protein 1147034..1147282 Francisella tularensis subsp. holarctica OSU18 4306818 YP_763671.1 CDS isftu1 NC_008369.1 1147306 1148186 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(1147306..1147635,1147635..1148186) Francisella tularensis subsp. holarctica OSU18 4306819 YP_763672.1 CDS FTH_1172 NC_008369.1 1148213 1149070 D DMT superfamily drug/metabolite transporter 1148213..1149070 Francisella tularensis subsp. holarctica OSU18 4306820 YP_763673.1 CDS pheS NC_008369.1 1149156 1150169 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1149156..1150169 Francisella tularensis subsp. holarctica OSU18 4306821 YP_763674.1 CDS pheT NC_008369.1 1150190 1152562 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1150190..1152562 Francisella tularensis subsp. holarctica OSU18 4306822 YP_763675.1 CDS fur1 NC_008369.1 1152605 1153036 R ferric (Fe3+) uptake regulator protein complement(1152605..1153036) Francisella tularensis subsp. holarctica OSU18 4306823 YP_763676.1 CDS FTH_1176 NC_008369.1 1153178 1154395 D GTP-binding protein 1153178..1154395 Francisella tularensis subsp. holarctica OSU18 4306824 YP_763677.1 CDS zupT NC_008369.1 1154398 1155144 D ZIP family zinc (Zn2+)-iron (Fe2+) permease 1154398..1155144 Francisella tularensis subsp. holarctica OSU18 4306825 YP_763678.1 CDS FTH_1178 NC_008369.1 1155166 1156155 R conserved in Francisella genomes; hypothetical protein complement(1155166..1156155) Francisella tularensis subsp. holarctica OSU18 4306826 YP_763679.1 CDS FTH_1179 NC_008369.1 1156323 1157753 R cardiolipin synthase complement(1156323..1157753) Francisella tularensis subsp. holarctica OSU18 4306827 YP_763680.1 CDS FTH_1180 NC_008369.1 1157845 1159272 R cardiolipin synthase complement(1157845..1159272) Francisella tularensis subsp. holarctica OSU18 4306828 YP_763681.1 CDS FTH_1182 NC_008369.1 1160653 1161513 D chromosome partitioning ATPase 1160653..1161513 Francisella tularensis subsp. holarctica OSU18 4306830 YP_763682.1 CDS dcd NC_008369.1 1161525 1162091 D Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1161525..1162091 Francisella tularensis subsp. holarctica OSU18 4306831 YP_763683.1 CDS FTH_1185 NC_008369.1 1163348 1163923 R conserved in Francisella genomes; hypothetical protein complement(1163348..1163923) Francisella tularensis subsp. holarctica OSU18 4306833 YP_763684.1 CDS leuS NC_008369.1 1163931 1166372 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(1163931..1166372) Francisella tularensis subsp. holarctica OSU18 4306834 YP_763685.1 CDS FTH_1187 NC_008369.1 1166480 1168375 R hypothetical protein complement(1166480..1168375) Francisella tularensis subsp. holarctica OSU18 4306835 YP_763686.1 CDS FTH_1188 NC_008369.1 1168387 1168485 R hypothetical protein complement(1168387..1168485) Francisella tularensis subsp. holarctica OSU18 4306836 YP_763687.1 CDS FTH_1189 NC_008369.1 1168504 1168761 R conserved in Francisella genomes; hypothetical protein complement(1168504..1168761) Francisella tularensis subsp. holarctica OSU18 4306837 YP_763688.1 CDS FTH_1190 NC_008369.1 1168884 1169009 R conserved in Francisella genomes; hypothetical protein complement(1168884..1169009) Francisella tularensis subsp. holarctica OSU18 4306838 YP_763689.1 CDS FTH_1191 NC_008369.1 1168963 1169082 R hypothetical protein complement(1168963..1169082) Francisella tularensis subsp. holarctica OSU18 4306839 YP_763690.1 CDS FTH_1192 NC_008369.1 1169175 1169585 R crossover junction endoribonuclease; hypothetical protein complement(1169175..1169585) Francisella tularensis subsp. holarctica OSU18 4306840 YP_763691.1 CDS FTH_1193 NC_008369.1 1169587 1170171 R hypothetical protein complement(1169587..1170171) Francisella tularensis subsp. holarctica OSU18 4306841 YP_763692.1 CDS FTH_1195 NC_008369.1 1170805 1171176 R conserved in Francisella genomes; hypothetical protein complement(1170805..1171176) Francisella tularensis subsp. holarctica OSU18 4306843 YP_763693.1 CDS FTH_1196 NC_008369.1 1171857 1172981 R hypothetical protein complement(1171857..1172981) Francisella tularensis subsp. holarctica OSU18 4306844 YP_763694.1 CDS FTH_1197 NC_008369.1 1173314 1174555 R hypothetical protein complement(1173314..1174555) Francisella tularensis subsp. holarctica OSU18 4306845 YP_763695.1 CDS FTH_1198 NC_008369.1 1174785 1176152 D APC family amino acid-polyamine-organocation transporter 1174785..1176152 Francisella tularensis subsp. holarctica OSU18 4306846 YP_763696.1 CDS FTH_1199 NC_008369.1 1176204 1176809 D conserved in Francisella genomes; hypothetical protein 1176204..1176809 Francisella tularensis subsp. holarctica OSU18 4306847 YP_763697.1 CDS FTH_1200 NC_008369.1 1176813 1177106 D transcriptional regulator 1176813..1177106 Francisella tularensis subsp. holarctica OSU18 4306848 YP_763698.1 CDS FTH_1201 NC_008369.1 1177231 1177512 R hypothetical protein complement(1177231..1177512) Francisella tularensis subsp. holarctica OSU18 4306849 YP_763699.1 CDS trxA2 NC_008369.1 1177505 1177831 R thioredoxin complement(1177505..1177831) Francisella tularensis subsp. holarctica OSU18 4306850 YP_763700.1 CDS FTH_1203 NC_008369.1 1177835 1178524 R hypothetical protein complement(1177835..1178524) Francisella tularensis subsp. holarctica OSU18 4306851 YP_763701.1 CDS FTH_1205 NC_008369.1 1179491 1180645 R ABC transporter ATP-binding protein complement(1179491..1180645) Francisella tularensis subsp. holarctica OSU18 4306853 YP_763702.1 CDS FTH_1206 NC_008369.1 1180649 1181398 R ABC transporter ATP-binding protein complement(1180649..1181398) Francisella tularensis subsp. holarctica OSU18 4306854 YP_763703.1 CDS FTH_1207 NC_008369.1 1181437 1182882 R with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB complement(1181437..1182882) Francisella tularensis subsp. holarctica OSU18 4306855 YP_763704.1 CDS FTH_1208 NC_008369.1 1182889 1183299 R transcriptional regulator complement(1182889..1183299) Francisella tularensis subsp. holarctica OSU18 4306856 YP_763705.1 CDS trkA NC_008369.1 1183452 1184825 D involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 1183452..1184825 Francisella tularensis subsp. holarctica OSU18 4306857 YP_763706.1 CDS FTH_1210 NC_008369.1 1184884 1186305 D APC family amino acid-polyamine-organocation transporter 1184884..1186305 Francisella tularensis subsp. holarctica OSU18 4306858 YP_763707.1 CDS FTH_1211 NC_008369.1 1186310 1186696 D hypothetical protein 1186310..1186696 Francisella tularensis subsp. holarctica OSU18 4306859 YP_763708.1 CDS FTH_1212 NC_008369.1 1186689 1187237 D hypothetical protein 1186689..1187237 Francisella tularensis subsp. holarctica OSU18 4306860 YP_763709.1 CDS infA NC_008369.1 1187267 1187485 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(1187267..1187485) Francisella tularensis subsp. holarctica OSU18 4306861 YP_763710.1 CDS FTH_1214 NC_008369.1 1187579 1188484 D hypothetical protein 1187579..1188484 Francisella tularensis subsp. holarctica OSU18 4306862 YP_763711.1 CDS FTH_1215 NC_008369.1 1188481 1188747 D conserved in Francisella genomes; hypothetical protein 1188481..1188747 Francisella tularensis subsp. holarctica OSU18 4306863 YP_763712.1 CDS ffh NC_008369.1 1188828 1190204 D type II general secretory pathway signal recognition particle protein Ffh 1188828..1190204 Francisella tularensis subsp. holarctica OSU18 4306864 YP_763713.1 CDS aroG NC_008369.1 1190236 1191348 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1190236..1191348 Francisella tularensis subsp. holarctica OSU18 4306865 YP_763714.1 CDS isftu1 NC_008369.1 1191536 1192416 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(1191536..1192087,1192087..1192416)) Francisella tularensis subsp. holarctica OSU18 4306867 YP_763715.1 CDS FTH_1220 NC_008369.1 1192664 1192996 R hypothetical protein complement(1192664..1192996) Francisella tularensis subsp. holarctica OSU18 4306868 YP_763716.1 CDS xthA NC_008369.1 1193278 1194066 D similar to Escherichia coli exonuclease III; exodeoxyribonuclease III 1193278..1194066 Francisella tularensis subsp. holarctica OSU18 4306869 YP_763717.1 CDS FTH_1222 NC_008369.1 1194087 1194794 D short chain dehydrogenase 1194087..1194794 Francisella tularensis subsp. holarctica OSU18 4306870 YP_763718.1 CDS FTH_1223 NC_008369.1 1194797 1195300 D kinase 1194797..1195300 Francisella tularensis subsp. holarctica OSU18 4306871 YP_763719.1 CDS FTH_1224 NC_008369.1 1195300 1196019 D conserved in Francisella genomes; hypothetical protein 1195300..1196019 Francisella tularensis subsp. holarctica OSU18 4306872 YP_763720.1 CDS gor NC_008369.1 1196057 1197418 D catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 1196057..1197418 Francisella tularensis subsp. holarctica OSU18 4306873 YP_763721.1 CDS FTH_1226 NC_008369.1 1197429 1197749 D hypothetical protein 1197429..1197749 Francisella tularensis subsp. holarctica OSU18 4306874 YP_763722.1 CDS FTH_1228 NC_008369.1 1198745 1200286 D POT family proton dependent peptide transporter 1198745..1200286 Francisella tularensis subsp. holarctica OSU18 4306876 YP_763723.1 CDS rhlE NC_008369.1 1200283 1201608 R ATP-dependent RNA helicase complement(1200283..1201608) Francisella tularensis subsp. holarctica OSU18 4307515 YP_763724.1 CDS folE NC_008369.1 1201735 1202355 D involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 1201735..1202355 Francisella tularensis subsp. holarctica OSU18 4307516 YP_763725.1 CDS FTH_1231 NC_008369.1 1202586 1203062 D hypothetical protein 1202586..1203062 Francisella tularensis subsp. holarctica OSU18 4307517 YP_763726.1 CDS FTH_1232 NC_008369.1 1203202 1203633 D hypothetical protein 1203202..1203633 Francisella tularensis subsp. holarctica OSU18 4307518 YP_763727.1 CDS FTH_1234 NC_008369.1 1204752 1205756 D oxidoreductase 1204752..1205756 Francisella tularensis subsp. holarctica OSU18 4307520 YP_763728.1 CDS trpG1 NC_008369.1 1206977 1207531 R anthranilate synthase component II complement(1206977..1207531) Francisella tularensis subsp. holarctica OSU18 4307522 YP_763729.1 CDS trpE1 NC_008369.1 1207533 1209296 R anthranilate synthase component I; anthranilate synthase complement(1207533..1209296) Francisella tularensis subsp. holarctica OSU18 4307523 YP_763730.1 CDS fadD2 NC_008369.1 1209289 1210671 R acyl-activating enzyme; long-chain-fatty-acid--CoA ligase complement(1209289..1210671) Francisella tularensis subsp. holarctica OSU18 4307524 YP_763731.1 CDS folB NC_008369.1 1210741 1211094 D dihydroneopterin aldolase 1210741..1211094 Francisella tularensis subsp. holarctica OSU18 4307525 YP_763732.1 CDS folK/folP NC_008369.1 1211096 1212361 D 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase 1211096..1212361 Francisella tularensis subsp. holarctica OSU18 4307526 YP_763733.1 CDS FTH_1241 NC_008369.1 1212374 1213294 D esterase 1212374..1213294 Francisella tularensis subsp. holarctica OSU18 4307527 YP_763734.1 CDS FTH_1242 NC_008369.1 1213310 1213810 D hypothetical protein 1213310..1213810 Francisella tularensis subsp. holarctica OSU18 4307528 YP_763735.1 CDS bioA NC_008369.1 1214972 1216258 R 7,8-diamino-pelargonic acid aminotransferase; adenosylmethionine-8-amino-7-oxononanoate aminotransferase complement(1214972..1216258) Francisella tularensis subsp. holarctica OSU18 4307530 YP_763736.1 CDS bioB NC_008369.1 1216349 1217290 D biotin synthetase; biotin synthase 1216349..1217290 Francisella tularensis subsp. holarctica OSU18 4307531 YP_763737.1 CDS bioF NC_008369.1 1217284 1218411 D 7-KAP synthetase; 8-amino-7-oxononanoate synthase 1217284..1218411 Francisella tularensis subsp. holarctica OSU18 4307532 YP_763738.1 CDS bioC NC_008369.1 1218389 1219126 D biotin synthesis protein BioC 1218389..1219126 Francisella tularensis subsp. holarctica OSU18 4307533 YP_763739.1 CDS bioD NC_008369.1 1219130 1219789 D DTB synthetase; dethiobiotin synthetase 1219130..1219789 Francisella tularensis subsp. holarctica OSU18 4307534 YP_763740.1 CDS birA1 NC_008369.1 1219897 1220712 R acetyl-CoA carboxylase biotin holoenzyme synthetase; biotin--[acetyl-CoA-carboxylase] ligase complement(1219897..1220712) Francisella tularensis subsp. holarctica OSU18 4307535 YP_763741.1 CDS FTH_1250 NC_008369.1 1220735 1221619 R ROK family protein complement(1220735..1221619) Francisella tularensis subsp. holarctica OSU18 4307536 YP_763742.1 CDS adc NC_008369.1 1223331 1223885 D converts acetoacetate to acetone and carbon dioxide; acetoacetate decarboxylase 1223331..1223885 Francisella tularensis subsp. holarctica OSU18 4307538 YP_763743.1 CDS FTH_1254 NC_008369.1 1224750 1226417 D beta-hexosaminidase; beta-N-acetylhexosaminidase 1224750..1226417 Francisella tularensis subsp. holarctica OSU18 4307540 YP_763744.1 CDS hemL NC_008369.1 1226438 1227733 R Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(1226438..1227733) Francisella tularensis subsp. holarctica OSU18 4307541 YP_763745.1 CDS gshB NC_008369.1 1227723 1228697 R catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase complement(1227723..1228697) Francisella tularensis subsp. holarctica OSU18 4307542 YP_763746.1 CDS fmt NC_008369.1 1228701 1229642 R formylmethionyl-transfer ribonucleic synthetase; methionyl-tRNA formyltransferase complement(1228701..1229642) Francisella tularensis subsp. holarctica OSU18 4307543 YP_763747.1 CDS FTH_1258 NC_008369.1 1229647 1230045 R conserved in Francisella genomes; hypothetical protein complement(1229647..1230045) Francisella tularensis subsp. holarctica OSU18 4307544 YP_763748.1 CDS rlmL NC_008369.1 1230147 1232300 R catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase complement(1230147..1232300) Francisella tularensis subsp. holarctica OSU18 4307545 YP_763749.1 CDS FTH_1260 NC_008369.1 1232375 1232929 R fatty acid hydroxylase complement(1232375..1232929) Francisella tularensis subsp. holarctica OSU18 4307546 YP_763750.1 CDS FTH_1262 NC_008369.1 1233650 1233772 D hypothetical protein 1233650..1233772 Francisella tularensis subsp. holarctica OSU18 4307549 YP_763751.1 CDS FTH_1263 NC_008369.1 1233894 1234403 R hypothetical protein complement(1233894..1234403) Francisella tularensis subsp. holarctica OSU18 4307550 YP_763752.1 CDS isftu1 NC_008369.1 1234360 1235240 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(1234360..1234911,1234911..1235240)) Francisella tularensis subsp. holarctica OSU18 4307551 YP_763753.1 CDS FTH_1266 NC_008369.1 1236505 1236975 D conserved in Francisella genomes; hypothetical protein 1236505..1236975 Francisella tularensis subsp. holarctica OSU18 4307553 YP_763754.1 CDS FTH_1267 NC_008369.1 1237112 1237936 D short-chain dehydrogenase/reductase; oxidoreductase 1237112..1237936 Francisella tularensis subsp. holarctica OSU18 4307554 YP_763755.1 CDS FTH_1269 NC_008369.1 1239543 1240415 R conserved in Francisella genomes; hypothetical protein complement(1239543..1240415) Francisella tularensis subsp. holarctica OSU18 4307556 YP_763756.1 CDS isftu1 NC_008369.1 1240583 1241463 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(1240583..1240912,1240912..1241463) Francisella tularensis subsp. holarctica OSU18 4307557 YP_763757.1 CDS FTH_1271 NC_008369.1 1241491 1241940 R conserved in Francisella genomes; hypothetical protein complement(1241491..1241940) Francisella tularensis subsp. holarctica OSU18 4307558 YP_763758.1 CDS FTH_1272 NC_008369.1 1241949 1242344 R hypothetical protein complement(1241949..1242344) Francisella tularensis subsp. holarctica OSU18 4307559 YP_763759.1 CDS poxF NC_008369.1 1243285 1244016 D phenol hydroxylase; phenol 2-monooxygenase 1243285..1244016 Francisella tularensis subsp. holarctica OSU18 4307561 YP_763760.2 CDS rpmE NC_008369.1 1244138 1244356 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1244138..1244356 Francisella tularensis subsp. holarctica OSU18 4307562 YP_763761.1 CDS gshA NC_008369.1 1244565 1246070 R gamma-glutamyl-L-cysteine synthetase; glutamate--cysteine ligase complement(1244565..1246070) Francisella tularensis subsp. holarctica OSU18 4307563 YP_763762.1 CDS mviN NC_008369.1 1246123 1247664 R virulence factor transporter MviN complement(1246123..1247664) Francisella tularensis subsp. holarctica OSU18 4307564 YP_763763.1 CDS FTH_1278 NC_008369.1 1247725 1248756 R conserved in Francisella genomes; hypothetical protein complement(1247725..1248756) Francisella tularensis subsp. holarctica OSU18 4307565 YP_763764.1 CDS FTH_1279 NC_008369.1 1248839 1249249 R ATP-binding protein complement(1248839..1249249) Francisella tularensis subsp. holarctica OSU18 4307566 YP_763765.1 CDS folC NC_008369.1 1249227 1250408 R 7,8-dihydrofolate synthetase; dihydrofolate synthase complement(1249227..1250408) Francisella tularensis subsp. holarctica OSU18 4307567 YP_763766.1 CDS accD NC_008369.1 1250423 1251331 R acetyl-CoA carboxylase subunit beta complement(1250423..1251331) Francisella tularensis subsp. holarctica OSU18 4306339 YP_763767.1 CDS ndk NC_008369.1 1251367 1251789 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(1251367..1251789) Francisella tularensis subsp. holarctica OSU18 4306340 YP_763768.1 CDS pyrG NC_008369.1 1251862 1253502 R CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(1251862..1253502) Francisella tularensis subsp. holarctica OSU18 4306341 YP_763769.1 CDS FTH_1285 NC_008369.1 1255601 1256533 R conserved in Francisella genomes; hypothetical protein complement(1255601..1256533) Francisella tularensis subsp. holarctica OSU18 4306343 YP_763770.1 CDS isftu1 NC_008369.1 1256980 1257860 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(1256980..1257309,1257309..1257860) Francisella tularensis subsp. holarctica OSU18 4306344 YP_763771.1 CDS FTH_1287 NC_008369.1 1258056 1259021 R conserved in Francisella genomes; hypothetical protein complement(1258056..1259021) Francisella tularensis subsp. holarctica OSU18 4306345 YP_763772.1 CDS FTH_1289 NC_008369.1 1260307 1260885 R hypothetical protein complement(1260307..1260885) Francisella tularensis subsp. holarctica OSU18 4306347 YP_763773.1 CDS FTH_1290 NC_008369.1 1260866 1261159 R hypothetical protein complement(1260866..1261159) Francisella tularensis subsp. holarctica OSU18 4306348 YP_763774.1 CDS fopA NC_008369.1 1267838 1269019 R outer membrane protein FopA complement(1267838..1269019) Francisella tularensis subsp. holarctica OSU18 4306351 YP_763775.1 CDS fdx NC_008369.1 1269126 1269371 R ferredoxin complement(1269126..1269371) Francisella tularensis subsp. holarctica OSU18 4306352 YP_763776.1 CDS coaD NC_008369.1 1269376 1269864 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(1269376..1269864) Francisella tularensis subsp. holarctica OSU18 4306353 YP_763777.1 CDS FTH_1296 NC_008369.1 1269876 1270427 R hypothetical protein complement(1269876..1270427) Francisella tularensis subsp. holarctica OSU18 4306354 YP_763778.1 CDS FTH_1297 NC_008369.1 1270441 1270797 R HesB family protein complement(1270441..1270797) Francisella tularensis subsp. holarctica OSU18 4306355 YP_763779.1 CDS csdB NC_008369.1 1270818 1272041 R selenocysteine beta-lyase; selenocysteine lyase complement(1270818..1272041) Francisella tularensis subsp. holarctica OSU18 4306356 YP_763780.1 CDS sdaA/tdcB NC_008369.1 1272144 1273517 R L-hydroxyaminoacid dehydratase; L-serine ammonia-lyase complement(1272144..1273517) Francisella tularensis subsp. holarctica OSU18 4306357 YP_763781.1 CDS FTH_1300 NC_008369.1 1273573 1274241 R hypothetical protein complement(1273573..1274241) Francisella tularensis subsp. holarctica OSU18 4306358 YP_763782.1 CDS pheA NC_008369.1 1274267 1275109 R prephenate dehydratase complement(1274267..1275109) Francisella tularensis subsp. holarctica OSU18 4306359 YP_763783.1 CDS alr NC_008369.1 1276885 1277982 R alanine racemase complement(1276885..1277982) Francisella tularensis subsp. holarctica OSU18 4306361 YP_763784.1 CDS FTH_1305 NC_008369.1 1279608 1280315 R hypothetical protein complement(1279608..1280315) Francisella tularensis subsp. holarctica OSU18 4306363 YP_763785.1 CDS FTH_1306 NC_008369.1 1280327 1280725 R conserved in Francisella genomes; hypothetical protein complement(1280327..1280725) Francisella tularensis subsp. holarctica OSU18 4306364 YP_763786.1 CDS FTH_1307 NC_008369.1 1280805 1281827 D hypothetical protein 1280805..1281827 Francisella tularensis subsp. holarctica OSU18 4306365 YP_763787.1 CDS glyS NC_008369.1 1286784 1288868 R glycyl translase; glycine--tRNA ligase complement(1286784..1288868) Francisella tularensis subsp. holarctica OSU18 4306371 YP_763788.1 CDS FTH_1314 NC_008369.1 1289061 1289735 D TatD family deoxyribonuclease 1289061..1289735 Francisella tularensis subsp. holarctica OSU18 4306372 YP_763789.1 CDS recF NC_008369.1 1289739 1290788 D DNA replication and repair protein RecF 1289739..1290788 Francisella tularensis subsp. holarctica OSU18 4307717 YP_763790.1 CDS FTH_1317 NC_008369.1 1291133 1291339 D conserved in Francisella genomes; hypothetical protein 1291133..1291339 Francisella tularensis subsp. holarctica OSU18 4307719 YP_763791.1 CDS FTH_1318 NC_008369.1 1291342 1292259 R hypothetical protein complement(1291342..1292259) Francisella tularensis subsp. holarctica OSU18 4307720 YP_763792.1 CDS galU NC_008369.1 1293732 1294595 R glucose-1-phosphate uridylyltransferase; UTP--glucose-1-phosphate uridylyltransferase complement(1293732..1294595) Francisella tularensis subsp. holarctica OSU18 4307722 YP_763793.1 CDS FTH_1321 NC_008369.1 1294612 1295751 R hypothetical protein complement(1294612..1295751) Francisella tularensis subsp. holarctica OSU18 4307723 YP_763794.1 CDS FTH_1322 NC_008369.1 1295842 1296411 R conserved in Francisella genomes; hypothetical protein complement(1295842..1296411) Francisella tularensis subsp. holarctica OSU18 4307724 YP_763795.1 CDS rpsU NC_008369.1 1297279 1297479 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(1297279..1297479) Francisella tularensis subsp. holarctica OSU18 4307727 YP_763796.1 CDS FTH_1325 NC_008369.1 1297856 1298053 D conserved in Francisella genomes; hypothetical protein 1297856..1298053 Francisella tularensis subsp. holarctica OSU18 4307728 YP_763797.1 CDS cspA NC_008369.1 1298252 1298455 D cold shock protein 1298252..1298455 Francisella tularensis subsp. holarctica OSU18 4307729 YP_763798.1 CDS FTH_1327 NC_008369.1 1298526 1299512 R hypothetical protein complement(1298526..1299512) Francisella tularensis subsp. holarctica OSU18 4307730 YP_763799.1 CDS FTH_1328 NC_008369.1 1299702 1300700 D hypothetical protein 1299702..1300700 Francisella tularensis subsp. holarctica OSU18 4307731 YP_763800.1 CDS FTH_1329 NC_008369.1 1300724 1301443 R transcriptional regulator complement(1300724..1301443) Francisella tularensis subsp. holarctica OSU18 4307732 YP_763801.1 CDS FTH_1330 NC_008369.1 1301642 1301842 D hypothetical protein 1301642..1301842 Francisella tularensis subsp. holarctica OSU18 4307733 YP_763802.1 CDS FTH_1332 NC_008369.1 1302682 1303485 D hypothetical protein 1302682..1303485 Francisella tularensis subsp. holarctica OSU18 4307735 YP_763803.1 CDS FTH_1333 NC_008369.1 1303582 1304073 D hypothetical protein 1303582..1304073 Francisella tularensis subsp. holarctica OSU18 4307736 YP_763804.1 CDS isftu1 NC_008369.1 1304170 1305050 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(1304170..1304721,1304721..1305050)) Francisella tularensis subsp. holarctica OSU18 4307737 YP_763805.1 CDS FTH_1335 NC_008369.1 1305426 1306241 R hypothetical protein complement(1305426..1306241) Francisella tularensis subsp. holarctica OSU18 4307738 YP_763806.1 CDS FTH_1336 NC_008369.1 1306681 1306914 D hypothetical protein 1306681..1306914 Francisella tularensis subsp. holarctica OSU18 4307739 YP_763807.1 CDS hslR NC_008369.1 1312344 1312712 D ribosome-associated heat shock protein Hsp15; heat shock protein 15 (HSP15) 1312344..1312712 Francisella tularensis subsp. holarctica OSU18 4307742 YP_763808.1 CDS FTH_1340 NC_008369.1 1312747 1314240 R sugar kinase complement(1312747..1314240) Francisella tularensis subsp. holarctica OSU18 4307743 YP_763809.1 CDS FTH_1341 NC_008369.1 1314408 1314536 D conserved in Francisella genomes; hypothetical protein 1314408..1314536 Francisella tularensis subsp. holarctica OSU18 4307744 YP_763810.1 CDS FTH_1342 NC_008369.1 1314547 1315167 R hypothetical protein complement(1314547..1315167) Francisella tularensis subsp. holarctica OSU18 4307745 YP_763811.1 CDS FTH_1345 NC_008369.1 1317498 1317968 R glutathione peroxidase complement(1317498..1317968) Francisella tularensis subsp. holarctica OSU18 4307748 YP_763812.1 CDS FTH_1346 NC_008369.1 1317997 1318287 R conserved in Francisella genomes; hypothetical protein complement(1317997..1318287) Francisella tularensis subsp. holarctica OSU18 4307749 YP_763813.1 CDS FTH_1347 NC_008369.1 1318441 1318887 D conserved in Francisella genomes; hypothetical protein 1318441..1318887 Francisella tularensis subsp. holarctica OSU18 4307750 YP_763814.1 CDS nadB NC_008369.1 1320976 1322463 R L-aspartate oxidase complement(1320976..1322463) Francisella tularensis subsp. holarctica OSU18 4307753 YP_763815.1 CDS nadC NC_008369.1 1322466 1323329 R nicotinate-nucleotide pyrophosphorylase (carboxylating); nicotinate-nucleotide diphosphorylase (carboxylating) complement(1322466..1323329) Francisella tularensis subsp. holarctica OSU18 4307754 YP_763816.1 CDS nadA NC_008369.1 1323338 1324363 R 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase complement(1323338..1324363) Francisella tularensis subsp. holarctica OSU18 4307755 YP_763817.1 CDS gmk NC_008369.1 1324384 1324956 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(1324384..1324956) Francisella tularensis subsp. holarctica OSU18 4307756 YP_763818.1 CDS FTH_1354 NC_008369.1 1325073 1326782 R ATP-dependent RNA helicase complement(1325073..1326782) Francisella tularensis subsp. holarctica OSU18 4307757 YP_763819.1 CDS FTH_1355 NC_008369.1 1326817 1327095 R cyclophilin; peptidyl-prolyl isomerase complement(1326817..1327095) Francisella tularensis subsp. holarctica OSU18 4307758 YP_763820.1 CDS galT NC_008369.1 1330087 1331112 D catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 1330087..1331112 Francisella tularensis subsp. holarctica OSU18 4307761 YP_763821.1 CDS galK NC_008369.1 1331115 1332263 D galactokinase 1331115..1332263 Francisella tularensis subsp. holarctica OSU18 4307762 YP_763822.1 CDS FTH_1360 NC_008369.1 1332260 1332655 R hypothetical protein complement(1332260..1332655) Francisella tularensis subsp. holarctica OSU18 4307763 YP_763823.1 CDS kdsB NC_008369.1 1332648 1333400 R CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase complement(1332648..1333400) Francisella tularensis subsp. holarctica OSU18 4307764 YP_763824.1 CDS FTH_1362 NC_008369.1 1333393 1333581 R hypothetical protein complement(1333393..1333581) Francisella tularensis subsp. holarctica OSU18 4307765 YP_763825.1 CDS isftu1 NC_008369.1 1334210 1335090 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(1334210..1334761,1334761..1335090)) Francisella tularensis subsp. holarctica OSU18 4307767 YP_763826.1 CDS FTH_1365 NC_008369.1 1335382 1336086 R hypothetical protein complement(1335382..1336086) Francisella tularensis subsp. holarctica OSU18 4307768 YP_763827.1 CDS rplT NC_008369.1 1336128 1336484 R binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 complement(1336128..1336484) Francisella tularensis subsp. holarctica OSU18 4307769 YP_763828.1 CDS rpmI NC_008369.1 1336520 1336717 R 50S ribosomal protein L35 complement(1336520..1336717) Francisella tularensis subsp. holarctica OSU18 4307770 YP_763829.1 CDS infC NC_008369.1 1336760 1337227 R elongation factor (EF); protein-synthesizing GTPase complement(1336760..1337227) Francisella tularensis subsp. holarctica OSU18 4307771 YP_763830.1 CDS thrS NC_008369.1 1337303 1339207 R catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase complement(1337303..1339207) Francisella tularensis subsp. holarctica OSU18 4307772 YP_763831.1 CDS FTH_1370 NC_008369.1 1339714 1341438 D conserved in Francisella genomes; multifunctional chitinase 1339714..1341438 Francisella tularensis subsp. holarctica OSU18 4307773 YP_763832.1 CDS FTH_1371 NC_008369.1 1341524 1341820 R conserved in Francisella genomes; hypothetical protein complement(1341524..1341820) Francisella tularensis subsp. holarctica OSU18 4307774 YP_763833.1 CDS gcvH2 NC_008369.1 1341810 1342190 R glycine cleavage system protein H complement(1341810..1342190) Francisella tularensis subsp. holarctica OSU18 4307775 YP_763834.1 CDS murG NC_008369.1 1342294 1343409 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 1342294..1343409 Francisella tularensis subsp. holarctica OSU18 4307776 YP_763835.1 CDS FTH_1374 NC_008369.1 1343419 1343757 D hypothetical protein 1343419..1343757 Francisella tularensis subsp. holarctica OSU18 4307777 YP_763836.1 CDS recR NC_008369.1 1343757 1344359 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1343757..1344359 Francisella tularensis subsp. holarctica OSU18 4307778 YP_763837.1 CDS spoT2 NC_008369.1 1344367 1346490 R (ppGpp)ase; guanosine-3',5'-bis(diphosphate) 3'-diphosphatase complement(1344367..1346490) Francisella tularensis subsp. holarctica OSU18 4307779 YP_763838.1 CDS FTH_1377 NC_008369.1 1346550 1347761 R hypothetical protein complement(1346550..1347761) Francisella tularensis subsp. holarctica OSU18 4307780 YP_763839.1 CDS FTH_1378 NC_008369.1 1347763 1348227 R capsule biosynthesis protein CapC complement(1347763..1348227) Francisella tularensis subsp. holarctica OSU18 4307781 YP_763840.1 CDS FTH_1379 NC_008369.1 1348252 1349469 R probable poly-gamma-glutamate synthesis protein; capsule biosynthesis protein complement(1348252..1349469) Francisella tularensis subsp. holarctica OSU18 4307782 YP_763841.1 CDS FTH_1380 NC_008369.1 1349545 1350801 R major facilitator transporter complement(1349545..1350801) Francisella tularensis subsp. holarctica OSU18 4307783 YP_763842.1 CDS ans NC_008369.1 1351473 1352336 R L-asparaginase; asparaginase complement(1351473..1352336) Francisella tularensis subsp. holarctica OSU18 4307789 YP_763843.1 CDS FTH_1382 NC_008369.1 1352552 1353370 R possible cyanophycinase; peptidase complement(1352552..1353370) Francisella tularensis subsp. holarctica OSU18 4307790 YP_763844.1 CDS FTH_1383 NC_008369.1 1353573 1354679 D sugar kinase 1353573..1354679 Francisella tularensis subsp. holarctica OSU18 4307791 YP_763845.1 CDS FTH_1384 NC_008369.1 1354961 1355623 R HAD superfamily haloacid dehalogenase hydrolase complement(1354961..1355623) Francisella tularensis subsp. holarctica OSU18 4307792 YP_763846.1 CDS FTH_1385 NC_008369.1 1355642 1356655 R glycosyl transferases group 1 family protein complement(1355642..1356655) Francisella tularensis subsp. holarctica OSU18 4307793 YP_763847.1 CDS FTH_1386 NC_008369.1 1356658 1357665 R glycosyltransferase complement(1356658..1357665) Francisella tularensis subsp. holarctica OSU18 4307794 YP_763848.1 CDS FTH_1387 NC_008369.1 1357682 1358641 R glycosyltransferase complement(1357682..1358641) Francisella tularensis subsp. holarctica OSU18 4307795 YP_763849.1 CDS FTH_1388 NC_008369.1 1358650 1359411 R conserved in Francisella genomes; hypothetical protein complement(1358650..1359411) Francisella tularensis subsp. holarctica OSU18 4307796 YP_763850.1 CDS FTH_1389 NC_008369.1 1359415 1360098 R hypothetical protein complement(1359415..1360098) Francisella tularensis subsp. holarctica OSU18 4307797 YP_763851.1 CDS FTH_1390 NC_008369.1 1360037 1361323 R bifunctional phosphoserine phosphatase/sugar nucleotidyltransferase complement(1360037..1361323) Francisella tularensis subsp. holarctica OSU18 4307798 YP_763852.1 CDS FTH_1391 NC_008369.1 1361337 1363028 R ABC transporter ATP-binding protein complement(1361337..1363028) Francisella tularensis subsp. holarctica OSU18 4307799 YP_763853.1 CDS waaG NC_008369.1 1363025 1364254 R glycosyltransferase I (outer core) complement(1363025..1364254) Francisella tularensis subsp. holarctica OSU18 4307800 YP_763854.1 CDS galE NC_008369.1 1364258 1365277 R galactowaldenase; UDP-glucose 4-epimerase complement(1364258..1365277) Francisella tularensis subsp. holarctica OSU18 4307801 YP_763855.1 CDS FTH_1394 NC_008369.1 1365270 1366664 R sugar transferase complement(1365270..1366664) Francisella tularensis subsp. holarctica OSU18 4307802 YP_763856.1 CDS rpe NC_008369.1 1366645 1367313 R D-ribulose phosphate-3-epimerase; D-ribulose-phosphate 3-epimerase complement(1366645..1367313) Francisella tularensis subsp. holarctica OSU18 4307803 YP_763857.1 CDS kdsD NC_008369.1 1367438 1368421 D arabinose phosphate isomerase; arabinose-5-phosphate isomerase 1367438..1368421 Francisella tularensis subsp. holarctica OSU18 4307804 YP_763858.1 CDS FTH_1397 NC_008369.1 1368425 1369015 R hypothetical protein complement(1368425..1369015) Francisella tularensis subsp. holarctica OSU18 4307805 YP_763859.1 CDS FTH_1400 NC_008369.1 1370525 1370854 R conserved in Francisella genomes; hypothetical protein complement(1370525..1370854) Francisella tularensis subsp. holarctica OSU18 4307808 YP_763860.1 CDS fabI NC_008369.1 1372832 1373614 R enoyl-ACP reductase; enoyl-[acyl-carrier-protein] reductase (NADH) complement(1372832..1373614) Francisella tularensis subsp. holarctica OSU18 4307811 YP_763861.1 CDS FTH_1404 NC_008369.1 1373900 1374613 D hypothetical protein 1373900..1374613 Francisella tularensis subsp. holarctica OSU18 4307812 YP_763862.1 CDS FTH_1405 NC_008369.1 1374603 1374872 D conserved in Francisella genomes; hypothetical protein 1374603..1374872 Francisella tularensis subsp. holarctica OSU18 4307813 YP_763863.1 CDS FTH_1409 NC_008369.1 1376856 1377230 R conserved in Francisella genomes; hypothetical protein complement(1376856..1377230) Francisella tularensis subsp. holarctica OSU18 4307816 YP_763864.1 CDS uvrC NC_008369.1 1377297 1379135 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C complement(1377297..1379135) Francisella tularensis subsp. holarctica OSU18 4307817 YP_763865.1 CDS rnd NC_008369.1 1379244 1380338 D RNase D; ribonuclease III 1379244..1380338 Francisella tularensis subsp. holarctica OSU18 4307818 YP_763866.1 CDS FTH_1412 NC_008369.1 1380367 1381581 D major facilitator transporter 1380367..1381581 Francisella tularensis subsp. holarctica OSU18 4307819 YP_763867.1 CDS FTH_1413 NC_008369.1 1381578 1381955 R hypothetical protein complement(1381578..1381955) Francisella tularensis subsp. holarctica OSU18 4307820 YP_763868.1 CDS rpmA NC_008369.1 1382342 1382596 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(1382342..1382596) Francisella tularensis subsp. holarctica OSU18 4307821 YP_763869.1 CDS rplU NC_008369.1 1382627 1382941 R 50S ribosomal protein L21 complement(1382627..1382941) Francisella tularensis subsp. holarctica OSU18 4307822 YP_763870.1 CDS secA NC_008369.1 1385004 1387724 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(1385004..1387724) Francisella tularensis subsp. holarctica OSU18 4307825 YP_763871.1 CDS FTH_1419 NC_008369.1 1387892 1388884 D hypothetical protein 1387892..1388884 Francisella tularensis subsp. holarctica OSU18 4307826 YP_763872.1 CDS FTH_1420 NC_008369.1 1388888 1389337 D conserved in Francisella genomes; hypothetical protein 1388888..1389337 Francisella tularensis subsp. holarctica OSU18 4307827 YP_763873.1 CDS deoD NC_008369.1 1389334 1390056 R inosine phosphorylase; purine nucleoside phosphorylase complement(1389334..1390056) Francisella tularensis subsp. holarctica OSU18 4307828 YP_763874.1 CDS isftu1 NC_008369.1 1390129 1391009 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(1390129..1390680,1390680..1391009)) Francisella tularensis subsp. holarctica OSU18 4307829 YP_763875.1 CDS ftsH/hflB NC_008369.1 1392037 1393983 R M41 family endopeptidase FtsH/HflB complement(1392037..1393983) Francisella tularensis subsp. holarctica OSU18 4307831 YP_763876.1 CDS uvrA NC_008369.1 1396443 1399265 R UvrABC excinuclease subunit A complement(1396443..1399265) Francisella tularensis subsp. holarctica OSU18 4307834 YP_763877.1 CDS greA NC_008369.1 1399304 1399786 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1399304..1399786) Francisella tularensis subsp. holarctica OSU18 4307835 YP_763878.1 CDS FTH_1429 NC_008369.1 1399820 1400404 R type IV pilus assembly protein complement(1399820..1400404) Francisella tularensis subsp. holarctica OSU18 4307836 YP_763879.1 CDS pgi NC_008369.1 1400405 1402030 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(1400405..1402030) Francisella tularensis subsp. holarctica OSU18 4307837 YP_763880.1 CDS FTH_1431 NC_008369.1 1402017 1402670 R thiamine kinase; thiamine diphosphokinase complement(1402017..1402670) Francisella tularensis subsp. holarctica OSU18 4307838 YP_763881.1 CDS guaB NC_008369.1 1402736 1404196 R IMP oxidoreductase; IMP dehydrogenase complement(1402736..1404196) Francisella tularensis subsp. holarctica OSU18 4307839 YP_763882.1 CDS pepA NC_008369.1 1404297 1405736 R cytosol aminopeptidase complement(1404297..1405736) Francisella tularensis subsp. holarctica OSU18 4307840 YP_763883.1 CDS FTH_1434 NC_008369.1 1405902 1406984 D hypothetical protein 1405902..1406984 Francisella tularensis subsp. holarctica OSU18 4307841 YP_763884.1 CDS FTH_1435 NC_008369.1 1406984 1408045 D hypothetical protein 1406984..1408045 Francisella tularensis subsp. holarctica OSU18 4307842 YP_763885.1 CDS FTH_1436 NC_008369.1 1408053 1409306 D M16 family peptidase 1408053..1409306 Francisella tularensis subsp. holarctica OSU18 4307843 YP_763886.1 CDS FTH_1437 NC_008369.1 1409313 1410536 D M16 family peptidase 1409313..1410536 Francisella tularensis subsp. holarctica OSU18 4307844 YP_763887.1 CDS FTH_1438 NC_008369.1 1410537 1411115 D N6-adenine-specific methyltransferase 1410537..1411115 Francisella tularensis subsp. holarctica OSU18 4307845 YP_763888.1 CDS FTH_1439 NC_008369.1 1411149 1411799 D hypothetical protein 1411149..1411799 Francisella tularensis subsp. holarctica OSU18 4307846 YP_763889.1 CDS miaE NC_008369.1 1411852 1412463 R tRNA-(ms(2)io(6)a)-hydroxylase complement(1411852..1412463) Francisella tularensis subsp. holarctica OSU18 4307847 YP_763890.1 CDS udp NC_008369.1 1412578 1413381 D pyrimidine phosphorylase; uridine phosphorylase 1412578..1413381 Francisella tularensis subsp. holarctica OSU18 4307848 YP_763891.1 CDS cdd NC_008369.1 1413402 1413803 D cytidine aminohydrolase; cytidine deaminase 1413402..1413803 Francisella tularensis subsp. holarctica OSU18 4307849 YP_763892.1 CDS FTH_1443 NC_008369.1 1413995 1417030 R bifunctional FAD/FMN dehydrogenase/Fe-S oxidoreductase complement(1413995..1417030) Francisella tularensis subsp. holarctica OSU18 4307851 YP_763893.1 CDS gpmI NC_008369.1 1417237 1418787 D catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 1417237..1418787 Francisella tularensis subsp. holarctica OSU18 4307852 YP_763894.1 CDS serS NC_008369.1 1418802 1420082 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1418802..1420082 Francisella tularensis subsp. holarctica OSU18 4307853 YP_763895.1 CDS FTH_1446 NC_008369.1 1420192 1421091 D D-fructokinase; fructokinase 1420192..1421091 Francisella tularensis subsp. holarctica OSU18 4307854 YP_763896.1 CDS FTH_1447 NC_008369.1 1421169 1422428 D MOP/MATE superfamily multidrug/oligosaccharidyl-lipid/polysaccharide flippase 1421169..1422428 Francisella tularensis subsp. holarctica OSU18 4307855 YP_763897.1 CDS FTH_1448 NC_008369.1 1422432 1422632 R conserved in Francisella genomes; hypothetical protein complement(1422432..1422632) Francisella tularensis subsp. holarctica OSU18 4307856 YP_763898.1 CDS FTH_1449 NC_008369.1 1422660 1423169 R conserved in Francisella genomes; hypothetical protein complement(1422660..1423169) Francisella tularensis subsp. holarctica OSU18 4307857 YP_763899.1 CDS cydD NC_008369.1 1423546 1425327 D in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1423546..1425327 Francisella tularensis subsp. holarctica OSU18 4307858 YP_763900.1 CDS cydC NC_008369.1 1425324 1426973 D in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1425324..1426973 Francisella tularensis subsp. holarctica OSU18 4307859 YP_763901.1 CDS dctA NC_008369.1 1426975 1428225 R DAACS family dicarboxylate/amino acid:sodium or proton symporter complement(1426975..1428225) Francisella tularensis subsp. holarctica OSU18 4307860 YP_763902.1 CDS tdcF NC_008369.1 1428364 1428744 R translation initiation inhibitor; endoribonuclease L-PSP complement(1428364..1428744) Francisella tularensis subsp. holarctica OSU18 4307861 YP_763903.1 CDS FTH_1454 NC_008369.1 1428744 1430288 R SulP family sulfate permease complement(1428744..1430288) Francisella tularensis subsp. holarctica OSU18 4307862 YP_763904.1 CDS FTH_1456 NC_008369.1 1431274 1432497 D proline/betaine transporter; major facilitator transporter 1431274..1432497 Francisella tularensis subsp. holarctica OSU18 4307864 YP_763905.1 CDS dgt NC_008369.1 1432481 1433806 R deoxy-GTPase; dGTPase complement(1432481..1433806) Francisella tularensis subsp. holarctica OSU18 4307865 YP_763906.1 CDS katG NC_008369.1 1433910 1436135 R catalase complement(1433910..1436135) Francisella tularensis subsp. holarctica OSU18 4307866 YP_763907.1 CDS isftu1 NC_008369.1 1436904 1437784 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(1436904..1437455,1437455..1437784)) Francisella tularensis subsp. holarctica OSU18 4307867 YP_763908.1 CDS FTH_1461 NC_008369.1 1438866 1440260 R possible D-Ala-D-Ala carboxypeptidase C; peptidase complement(1438866..1440260) Francisella tularensis subsp. holarctica OSU18 4307869 YP_763909.1 CDS glpT NC_008369.1 1440276 1441592 R major facilitator superfamily glycerol-3-phosphate uniporter complement(1440276..1441592) Francisella tularensis subsp. holarctica OSU18 4307870 YP_763910.1 CDS ugpQ NC_008369.1 1441699 1442733 R glycerophosphoryl diester phosphodiesterase; glycerophosphodiester phosphodiesterase complement(1441699..1442733) Francisella tularensis subsp. holarctica OSU18 4307871 YP_763911.1 CDS FTH_1465 NC_008369.1 1443833 1444765 D ABC transporter ATP-binding protein 1443833..1444765 Francisella tularensis subsp. holarctica OSU18 4307873 YP_763912.1 CDS FTH_1468 NC_008369.1 1446762 1447106 R conserved in Francisella genomes; hypothetical protein complement(1446762..1447106) Francisella tularensis subsp. holarctica OSU18 4307876 YP_763913.1 CDS upp NC_008369.1 1448113 1448757 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(1448113..1448757) Francisella tularensis subsp. holarctica OSU18 4307878 YP_763914.1 CDS FTH_1471 NC_008369.1 1448934 1451216 R chitinase complement(1448934..1451216) Francisella tularensis subsp. holarctica OSU18 4307879 YP_763915.1 CDS kbl NC_008369.1 1451733 1452947 D catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 1451733..1452947 Francisella tularensis subsp. holarctica OSU18 4307880 YP_763916.1 CDS tdh NC_008369.1 1452970 1454025 D converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 1452970..1454025 Francisella tularensis subsp. holarctica OSU18 4307881 YP_763917.1 CDS FTH_1474 NC_008369.1 1454027 1455172 D HAAAP family serine permease 1454027..1455172 Francisella tularensis subsp. holarctica OSU18 4307882 YP_763918.1 CDS ispD NC_008369.1 1455296 1455985 R 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(1455296..1455985) Francisella tularensis subsp. holarctica OSU18 4307883 YP_763919.1 CDS ftsB NC_008369.1 1455975 1456265 R cell division initiator protein FtsB complement(1455975..1456265) Francisella tularensis subsp. holarctica OSU18 4307884 YP_763920.1 CDS eno NC_008369.1 1456273 1457643 R enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase complement(1456273..1457643) Francisella tularensis subsp. holarctica OSU18 4307885 YP_763921.1 CDS FTH_1478 NC_008369.1 1457752 1459005 R major facilitator transporter complement(1457752..1459005) Francisella tularensis subsp. holarctica OSU18 4307886 YP_763922.1 CDS FTH_1479 NC_008369.1 1459093 1459887 R nicotinamide mononucleotide transporter complement(1459093..1459887) Francisella tularensis subsp. holarctica OSU18 4307887 YP_763923.1 CDS FTH_1480 NC_008369.1 1459970 1460605 R bifunctional transcriptional regulator/sugar kinase complement(1459970..1460605) Francisella tularensis subsp. holarctica OSU18 4307888 YP_763924.1 CDS rumA NC_008369.1 1460615 1461964 R in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase complement(1460615..1461964) Francisella tularensis subsp. holarctica OSU18 4307889 YP_763925.1 CDS FTH_1482 NC_008369.1 1462053 1462625 R conserved in Francisella genomes; hypothetical protein complement(1462053..1462625) Francisella tularensis subsp. holarctica OSU18 4307890 YP_763926.1 CDS rpoZ NC_008369.1 1462890 1463108 R DNA-dependent RNA polymerase; DNA-directed RNA polymerase complement(1462890..1463108) Francisella tularensis subsp. holarctica OSU18 4307892 YP_763927.1 CDS udk NC_008369.1 1463101 1463766 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(1463101..1463766) Francisella tularensis subsp. holarctica OSU18 4307893 YP_763928.1 CDS kdsA NC_008369.1 1463777 1464625 R catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase complement(1463777..1464625) Francisella tularensis subsp. holarctica OSU18 4307894 YP_763929.1 CDS FTH_1486 NC_008369.1 1464635 1464985 R essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA complement(1464635..1464985) Francisella tularensis subsp. holarctica OSU18 4307895 YP_763930.1 CDS pnp NC_008369.1 1464991 1467072 R polynucleotide phosphorylase; polynucleotide phosphorylase/polyadenylase complement(1464991..1467072) Francisella tularensis subsp. holarctica OSU18 4307896 YP_763931.1 CDS rpsO NC_008369.1 1467129 1467395 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(1467129..1467395) Francisella tularensis subsp. holarctica OSU18 4307897 YP_763932.1 CDS ftsI NC_008369.1 1467501 1469195 R penicillin binding protein (3 or 1B); peptidoglycan glycosyltransferase complement(1467501..1469195) Francisella tularensis subsp. holarctica OSU18 4307898 YP_763933.1 CDS FTH_1490 NC_008369.1 1469188 1469538 R conserved in Francisella genomes; hypothetical protein complement(1469188..1469538) Francisella tularensis subsp. holarctica OSU18 4307899 YP_763934.1 CDS mraW NC_008369.1 1469535 1470452 R S-adenosyl-methyltransferase MraW complement(1469535..1470452) Francisella tularensis subsp. holarctica OSU18 4307900 YP_763935.1 CDS FTH_1492 NC_008369.1 1470458 1472557 R acyl-coenzyme A synthetase complement(1470458..1472557) Francisella tularensis subsp. holarctica OSU18 4307901 YP_763936.1 CDS mutM NC_008369.1 1472650 1473474 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 1472650..1473474 Francisella tularensis subsp. holarctica OSU18 4307902 YP_763937.1 CDS isftu1 NC_008369.1 1473545 1474425 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(1473545..1473874,1473874..1474425) Francisella tularensis subsp. holarctica OSU18 4307903 YP_763938.2 CDS FTH_1495 NC_008369.1 1474433 1474972 R with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT complement(1474433..1474972) Francisella tularensis subsp. holarctica OSU18 4307904 YP_763939.1 CDS FTH_1496 NC_008369.1 1474975 1475838 R with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS complement(1474975..1475838) Francisella tularensis subsp. holarctica OSU18 4307905 YP_763940.1 CDS gyrB NC_008369.1 1475968 1478379 R DNA gyrase; DNA topoisomerase complement(1475968..1478379) Francisella tularensis subsp. holarctica OSU18 4307906 YP_763941.1 CDS FTH_1498 NC_008369.1 1478561 1479361 D hypothetical protein 1478561..1479361 Francisella tularensis subsp. holarctica OSU18 4307907 YP_763942.1 CDS dusA NC_008369.1 1479395 1480378 D tRNA-dihydrouridine synthase A 1479395..1480378 Francisella tularensis subsp. holarctica OSU18 4307908 YP_763943.1 CDS FTH_1500 NC_008369.1 1480385 1481152 R hypothetical protein complement(1480385..1481152) Francisella tularensis subsp. holarctica OSU18 4307909 YP_763944.1 CDS FTH_1501 NC_008369.1 1481651 1481899 R conserved in Francisella genomes; hypothetical protein complement(1481651..1481899) Francisella tularensis subsp. holarctica OSU18 4307910 YP_763945.1 CDS FTH_1502 NC_008369.1 1481820 1482134 D conserved in Francisella genomes; hypothetical protein 1481820..1482134 Francisella tularensis subsp. holarctica OSU18 4307911 YP_763946.1 CDS FTH_1503 NC_008369.1 1482142 1484055 R conserved in Francisella genomes; hypothetical protein complement(1482142..1484055) Francisella tularensis subsp. holarctica OSU18 4307912 YP_763947.1 CDS sucC NC_008369.1 1484225 1485388 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1484225..1485388 Francisella tularensis subsp. holarctica OSU18 4307913 YP_763948.1 CDS sucD NC_008369.1 1485420 1486292 D succinate thiokinase; succinate--CoA ligase (ADP-forming) 1485420..1486292 Francisella tularensis subsp. holarctica OSU18 4307914 YP_763949.1 CDS FTH_1506 NC_008369.1 1486402 1486827 D conserved in Francisella genomes; hypothetical protein 1486402..1486827 Francisella tularensis subsp. holarctica OSU18 4307915 YP_763950.1 CDS FTH_1507 NC_008369.1 1486986 1487207 R hypothetical protein complement(1486986..1487207) Francisella tularensis subsp. holarctica OSU18 4307916 YP_763951.1 CDS FTH_1508 NC_008369.1 1487211 1488251 D hypothetical protein 1487211..1488251 Francisella tularensis subsp. holarctica OSU18 4307917 YP_763952.1 CDS ddlA NC_008369.1 1488383 1489600 R alanine:alanine ligase (ADP-forming); D-alanine--D-alanine ligase complement(1488383..1489600) Francisella tularensis subsp. holarctica OSU18 4307918 YP_763953.1 CDS aspG NC_008369.1 1491277 1492197 D L-asparaginase; asparaginase 1491277..1492197 Francisella tularensis subsp. holarctica OSU18 4307920 YP_763954.1 CDS cutC NC_008369.1 1493787 1494509 D CutC family copper (Cu2+) homeostasis protein 1493787..1494509 Francisella tularensis subsp. holarctica OSU18 4307923 YP_763955.1 CDS araJ NC_008369.1 1494524 1495690 R arabinose permease; major facilitator transporter complement(1494524..1495690) Francisella tularensis subsp. holarctica OSU18 4307924 YP_763956.1 CDS FTH_1516 NC_008369.1 1495801 1496727 D LysR family transcriptional regulator 1495801..1496727 Francisella tularensis subsp. holarctica OSU18 4307925 YP_763957.1 CDS gph NC_008369.1 1496768 1497442 D phosphoglycolate phosphatase 1496768..1497442 Francisella tularensis subsp. holarctica OSU18 4307926 YP_763958.1 CDS trxB NC_008369.1 1498794 1499744 D NADP--thioredoxin reductase; thioredoxin reductase 1498794..1499744 Francisella tularensis subsp. holarctica OSU18 4307928 YP_763959.1 CDS mutL NC_008369.1 1502895 1504697 R DNA mismatch repair protein complement(1502895..1504697) Francisella tularensis subsp. holarctica OSU18 4307932 YP_763960.1 CDS FTH_1525 NC_008369.1 1505436 1506155 R conserved in Francisella genomes; hypothetical protein complement(1505436..1506155) Francisella tularensis subsp. holarctica OSU18 4307934 YP_763961.1 CDS FTH_1526 NC_008369.1 1506309 1507196 D GTP-binding protein 1506309..1507196 Francisella tularensis subsp. holarctica OSU18 4307935 YP_763962.1 CDS FTH_1527 NC_008369.1 1507415 1508230 D conserved in Francisella genomes; hypothetical protein 1507415..1508230 Francisella tularensis subsp. holarctica OSU18 4307936 YP_763963.1 CDS potF NC_008369.1 1508483 1509664 R putrescine ABC transporter ATP-binding protein complement(1508483..1509664) Francisella tularensis subsp. holarctica OSU18 4307937 YP_763964.1 CDS xasA NC_008369.1 1509748 1511157 D probable glutamate:gamma-aminobutyric acid transporter; gamma-glutamate APC transporter 1509748..1511157 Francisella tularensis subsp. holarctica OSU18 4307938 YP_763965.1 CDS FTH_1530 NC_008369.1 1511259 1512365 D PerM family protein 1511259..1512365 Francisella tularensis subsp. holarctica OSU18 4307939 YP_763966.1 CDS recJ NC_008369.1 1512359 1514101 D single-stranded-DNA-specific exonuclease RecJ 1512359..1514101 Francisella tularensis subsp. holarctica OSU18 4307940 YP_763967.1 CDS birA2 NC_008369.1 1514098 1514880 D acetyl-CoA carboxylase biotin holoenzyme synthetase; biotin--[acetyl-CoA-carboxylase] ligase 1514098..1514880 Francisella tularensis subsp. holarctica OSU18 4307941 YP_763968.1 CDS poxA NC_008369.1 1514877 1515800 D lysine translase; lysine--tRNA ligase 1514877..1515800 Francisella tularensis subsp. holarctica OSU18 4307942 YP_763969.1 CDS FTH_1536 NC_008369.1 1517809 1518489 R conserved in Francisella genomes; hypothetical protein complement(1517809..1518489) Francisella tularensis subsp. holarctica OSU18 4306558 YP_763970.1 CDS accC NC_008369.1 1518583 1519938 R acetyl-CoA carboxylase biotin carboxylase subunit complement(1518583..1519938) Francisella tularensis subsp. holarctica OSU18 4306559 YP_763971.1 CDS accB NC_008369.1 1520003 1520476 R acetyl-CoA carboxylase biotin carboxyl carrier protein subunit complement(1520003..1520476) Francisella tularensis subsp. holarctica OSU18 4306560 YP_763972.1 CDS aroD NC_008369.1 1520481 1520918 R catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase complement(1520481..1520918) Francisella tularensis subsp. holarctica OSU18 4306561 YP_763973.1 CDS apaH NC_008369.1 1520922 1521749 R hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase complement(1520922..1521749) Francisella tularensis subsp. holarctica OSU18 4306562 YP_763974.1 CDS ksgA NC_008369.1 1521761 1522549 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(1521761..1522549) Francisella tularensis subsp. holarctica OSU18 4306563 YP_763975.1 CDS surA NC_008369.1 1522551 1523978 R cyclophilin; peptidyl-prolyl isomerase complement(1522551..1523978) Francisella tularensis subsp. holarctica OSU18 4306564 YP_763976.1 CDS ostA NC_008369.1 1523960 1526566 R organic solvent tolerance protein complement(1523960..1526566) Francisella tularensis subsp. holarctica OSU18 4306565 YP_763977.1 CDS argS NC_008369.1 1526692 1528437 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1526692..1528437 Francisella tularensis subsp. holarctica OSU18 4306566 YP_763978.1 CDS FTH_1545 NC_008369.1 1528489 1528875 R hypothetical protein complement(1528489..1528875) Francisella tularensis subsp. holarctica OSU18 4306567 YP_763979.1 CDS ansB NC_008369.1 1529294 1530214 R L-asparaginase; asparaginase complement(1529294..1530214) Francisella tularensis subsp. holarctica OSU18 4306568 YP_763980.1 CDS yibK NC_008369.1 1530475 1530942 R tRNA/rRNA methyltransferase complement(1530475..1530942) Francisella tularensis subsp. holarctica OSU18 4306569 YP_763981.1 CDS hemB NC_008369.1 1530946 1531920 R catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase complement(1530946..1531920) Francisella tularensis subsp. holarctica OSU18 4306570 YP_763982.1 CDS yhbY NC_008369.1 1531928 1532206 R RNA-binding protein complement(1531928..1532206) Francisella tularensis subsp. holarctica OSU18 4306571 YP_763983.1 CDS holB NC_008369.1 1532217 1533128 R DNA nucleotidyltransferase (DNA-directed); DNA polymerase III, delta prime subunit complement(1532217..1533128) Francisella tularensis subsp. holarctica OSU18 4306572 YP_763984.1 CDS sohB NC_008369.1 1533136 1534152 R SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease complement(1533136..1534152) Francisella tularensis subsp. holarctica OSU18 4306573 YP_763985.1 CDS gst NC_008369.1 1534164 1534796 R glutathione S-transferase complement(1534164..1534796) Francisella tularensis subsp. holarctica OSU18 4306574 YP_763986.1 CDS dsrC NC_008369.1 1534882 1535196 D dissimilatory sulfite reductase subunit gamma 1534882..1535196 Francisella tularensis subsp. holarctica OSU18 4306575 YP_763987.1 CDS FTH_1554 NC_008369.1 1535187 1535480 D hypothetical protein 1535187..1535480 Francisella tularensis subsp. holarctica OSU18 4306576 YP_763988.1 CDS FTH_1555 NC_008369.1 1535572 1537332 D amylophosphorylase; phosphorylase 1535572..1537332 Francisella tularensis subsp. holarctica OSU18 4306577 YP_763989.1 CDS isftu1 NC_008369.1 1537617 1538497 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(1537617..1538168,1538168..1538497)) Francisella tularensis subsp. holarctica OSU18 4306578 YP_763990.1 CDS wcaA NC_008369.1 1538656 1539612 R glycosyl transferase family protein complement(1538656..1539612) Francisella tularensis subsp. holarctica OSU18 4306580 YP_763991.1 CDS FTH_1559 NC_008369.1 1539711 1540517 D hypothetical protein 1539711..1540517 Francisella tularensis subsp. holarctica OSU18 4306581 YP_763992.1 CDS ftsW NC_008369.1 1540525 1541730 R cell division protein FtsW complement(1540525..1541730) Francisella tularensis subsp. holarctica OSU18 4306582 YP_763993.1 CDS murD NC_008369.1 1541740 1542990 R D-glutamate ligase; UDP-N-acetylmuramoylalanine--D-glutamate ligase complement(1541740..1542990) Francisella tularensis subsp. holarctica OSU18 4306583 YP_763994.1 CDS mraY NC_008369.1 1542990 1544087 R First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(1542990..1544087) Francisella tularensis subsp. holarctica OSU18 4306584 YP_763995.1 CDS pckA NC_008369.1 1544162 1545754 R PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase complement(1544162..1545754) Francisella tularensis subsp. holarctica OSU18 4306585 YP_763996.1 CDS glnS NC_008369.1 1545899 1547545 D catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 1545899..1547545 Francisella tularensis subsp. holarctica OSU18 4306586 YP_763997.1 CDS FTH_1567 NC_008369.1 1549595 1551436 R ABC transporter ATP-binding protein complement(1549595..1551436) Francisella tularensis subsp. holarctica OSU18 4306589 YP_763998.1 CDS tet NC_008369.1 1551470 1552696 R major facilitator superfamily tetracycline exporter complement(1551470..1552696) Francisella tularensis subsp. holarctica OSU18 4307301 YP_763999.1 CDS FTH_1569 NC_008369.1 1552779 1553822 R hypothetical protein complement(1552779..1553822) Francisella tularensis subsp. holarctica OSU18 4307302 YP_764000.1 CDS FTH_1570 NC_008369.1 1554094 1555287 D major facilitator superfamily bicyclomycin exporter 1554094..1555287 Francisella tularensis subsp. holarctica OSU18 4307303 YP_764001.1 CDS FTH_1571 NC_008369.1 1555317 1555961 D hypothetical protein 1555317..1555961 Francisella tularensis subsp. holarctica OSU18 4307304 YP_764002.1 CDS FTH_1574 NC_008369.1 1557931 1559637 D conserved in Francisella genomes; hypothetical protein 1557931..1559637 Francisella tularensis subsp. holarctica OSU18 4307307 YP_764003.1 CDS isftu1 NC_008369.1 1559638 1560518 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1; ISFtu1 transposase complement(join(1559638..1560189,1560189..1560518)) Francisella tularensis subsp. holarctica OSU18 4307308 YP_764004.1 CDS FTH_1577 NC_008369.1 1561948 1562673 R hypothetical protein complement(1561948..1562673) Francisella tularensis subsp. holarctica OSU18 4307310 YP_764005.1 CDS FTH_1578 NC_008369.1 1562854 1563849 R LysR family transcriptional regulator complement(1562854..1563849) Francisella tularensis subsp. holarctica OSU18 4307311 YP_764006.1 CDS FTH_1579 NC_008369.1 1564386 1566500 D chitinase 1564386..1566500 Francisella tularensis subsp. holarctica OSU18 4307312 YP_764007.1 CDS ubiG NC_008369.1 1569018 1569713 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 1569018..1569713 Francisella tularensis subsp. holarctica OSU18 4307314 YP_764008.1 CDS FTH_1582 NC_008369.1 1569716 1570459 D conserved in Francisella genomes; hypothetical protein 1569716..1570459 Francisella tularensis subsp. holarctica OSU18 4307315 YP_764009.1 CDS FTH_1583 NC_008369.1 1570456 1570692 D hypothetical protein 1570456..1570692 Francisella tularensis subsp. holarctica OSU18 4307316 YP_764010.1 CDS FTH_1585 NC_008369.1 1572345 1572626 D hypothetical protein 1572345..1572626 Francisella tularensis subsp. holarctica OSU18 4307318 YP_764011.1 CDS FTH_1586 NC_008369.1 1572640 1572879 R conserved in Francisella genomes; hypothetical protein complement(1572640..1572879) Francisella tularensis subsp. holarctica OSU18 4307319 YP_764012.1 CDS glpK NC_008369.1 1573746 1575254 R ATP:glycerol 3-phosphotransferase; glycerol kinase complement(1573746..1575254) Francisella tularensis subsp. holarctica OSU18 4307321 YP_764013.1 CDS FTH_1589 NC_008369.1 1575323 1576579 R major facilitator transporter complement(1575323..1576579) Francisella tularensis subsp. holarctica OSU18 4307322 YP_764014.1 CDS FTH_1590 NC_008369.1 1576694 1577305 R conserved in Francisella genomes; hypothetical protein complement(1576694..1577305) Francisella tularensis subsp. holarctica OSU18 4307323 YP_764015.1 CDS FTH_1591 NC_008369.1 1577439 1578641 D major facilitator transporter 1577439..1578641 Francisella tularensis subsp. holarctica OSU18 4307324 YP_764016.1 CDS uvrD2 NC_008369.1 1584063 1586285 R DNA helicase II complement(1584063..1586285) Francisella tularensis subsp. holarctica OSU18 4307330 YP_764017.1 CDS ftsY NC_008369.1 1586376 1587407 R signal recognition particle receptor FtsY complement(1586376..1587407) Francisella tularensis subsp. holarctica OSU18 4307331 YP_764018.1 CDS FTH_1599 NC_008369.1 1587404 1588720 R conserved in Francisella genomes; hypothetical protein complement(1587404..1588720) Francisella tularensis subsp. holarctica OSU18 4307332 YP_764019.1 CDS prfC NC_008369.1 1588795 1590372 R stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 complement(1588795..1590372) Francisella tularensis subsp. holarctica OSU18 4307333 YP_764020.1 CDS tmk NC_008369.1 1590434 1591063 R catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase complement(1590434..1591063) Francisella tularensis subsp. holarctica OSU18 4307334 YP_764021.1 CDS nupC1 NC_008369.1 1591076 1592278 R CNT family concentrative nucleoside transporter, membrane protein complement(1591076..1592278) Francisella tularensis subsp. holarctica OSU18 4307335 YP_764022.1 CDS nupC2 NC_008369.1 1592297 1593496 R nucleoside transporter complement(1592297..1593496) Francisella tularensis subsp. holarctica OSU18 4307336 YP_764023.1 CDS deoC NC_008369.1 1593486 1594247 R deoxyriboaldolase; deoxyribose-phosphate aldolase complement(1593486..1594247) Francisella tularensis subsp. holarctica OSU18 4307337 YP_764024.1 CDS deoB NC_008369.1 1594210 1595454 R catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase complement(1594210..1595454) Francisella tularensis subsp. holarctica OSU18 4307338 YP_764025.1 CDS FTH_1606 NC_008369.1 1595459 1596223 R type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase complement(1595459..1596223) Francisella tularensis subsp. holarctica OSU18 4307339 YP_764026.1 CDS polA NC_008369.1 1596243 1598936 R DNA nucleotidyltransferase (DNA-directed); DNA polymerase I complement(1596243..1598936) Francisella tularensis subsp. holarctica OSU18 4307340 YP_764027.1 CDS lpxK NC_008369.1 1599032 1600000 R transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase complement(1599032..1600000) Francisella tularensis subsp. holarctica OSU18 4307341 YP_764028.1 CDS valA NC_008369.1 1600006 1601835 R ABC transporter ATP-binding protein complement(1600006..1601835) Francisella tularensis subsp. holarctica OSU18 4307342 YP_764029.1 CDS cca NC_008369.1 1601940 1603022 D catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 1601940..1603022 Francisella tularensis subsp. holarctica OSU18 4307343 YP_764030.1 CDS dsbB NC_008369.1 1603062 1603553 D disulfide bond formation protein 1603062..1603553 Francisella tularensis subsp. holarctica OSU18 4307344 YP_764031.1 CDS FTH_1612 NC_008369.1 1603566 1604939 D RND efflux transporter 1603566..1604939 Francisella tularensis subsp. holarctica OSU18 4307345 YP_764032.1 CDS FTH_1613 NC_008369.1 1604939 1608052 D resistance-nodulation-cell division acriflavin:proton (H+) antiporter 1604939..1608052 Francisella tularensis subsp. holarctica OSU18 4307346 YP_764033.1 CDS FTH_1614 NC_008369.1 1608184 1609464 D major facilitator transporter 1608184..1609464 Francisella tularensis subsp. holarctica OSU18 4307347 YP_764034.1 CDS FTH_1615 NC_008369.1 1609709 1610290 D hypothetical protein 1609709..1610290 Francisella tularensis subsp. holarctica OSU18 4307348 YP_764035.1 CDS FTH_1617 NC_008369.1 1611736 1612749 R possible microcin C7 resistance protein; hypothetical protein complement(1611736..1612749) Francisella tularensis subsp. holarctica OSU18 4307350 YP_764036.1 CDS isftu1 NC_008369.1 1614317 1615197 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(1614317..1614646,1614646..1615197) Francisella tularensis subsp. holarctica OSU18 4307353 YP_764037.1 CDS FTH_1621 NC_008369.1 1615249 1615500 D hypothetical protein 1615249..1615500 Francisella tularensis subsp. holarctica OSU18 4307354 YP_764038.1 CDS cysS NC_008369.1 1615568 1616962 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1615568..1616962 Francisella tularensis subsp. holarctica OSU18 4307355 YP_764039.1 CDS hemK NC_008369.1 1616966 1617910 D involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1616966..1617910 Francisella tularensis subsp. holarctica OSU18 4307356 YP_764040.1 CDS FTH_1624 NC_008369.1 1617966 1619153 D major facilitator transporter 1617966..1619153 Francisella tularensis subsp. holarctica OSU18 4307357 YP_764041.1 CDS FTH_1625 NC_008369.1 1619167 1619658 D acetyltransferase 1619167..1619658 Francisella tularensis subsp. holarctica OSU18 4307358 YP_764042.1 CDS isftu1 NC_008369.1 1619804 1620684 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(1619804..1620133,1620133..1620684) Francisella tularensis subsp. holarctica OSU18 4307359 YP_764043.1 CDS FTH_1627 NC_008369.1 1620997 1621848 R conserved in Francisella genomes; hypothetical protein complement(1620997..1621848) Francisella tularensis subsp. holarctica OSU18 4307360 YP_764044.1 CDS FTH_1628 NC_008369.1 1621852 1622781 R hypothetical protein complement(1621852..1622781) Francisella tularensis subsp. holarctica OSU18 4307361 YP_764045.1 CDS FTH_1629 NC_008369.1 1622800 1623036 R conserved in Francisella genomes; hypothetical protein complement(1622800..1623036) Francisella tularensis subsp. holarctica OSU18 4307362 YP_764046.1 CDS FTH_1630 NC_008369.1 1623187 1623507 R conserved in Francisella genomes; hypothetical protein complement(1623187..1623507) Francisella tularensis subsp. holarctica OSU18 4307363 YP_764047.1 CDS FTH_1631 NC_008369.1 1623620 1624093 R conserved in Francisella genomes; hypothetical protein complement(1623620..1624093) Francisella tularensis subsp. holarctica OSU18 4307364 YP_764048.1 CDS FTH_1632 NC_008369.1 1624301 1625491 R hypothetical protein complement(1624301..1625491) Francisella tularensis subsp. holarctica OSU18 4307365 YP_764049.1 CDS FTH_1633 NC_008369.1 1625488 1626291 R hypothetical protein complement(1625488..1626291) Francisella tularensis subsp. holarctica OSU18 4307366 YP_764050.1 CDS FTH_1634 NC_008369.1 1626275 1626622 R hypothetical protein complement(1626275..1626622) Francisella tularensis subsp. holarctica OSU18 4307367 YP_764051.1 CDS FTH_1636 NC_008369.1 1628006 1629685 R glycosyltransferase complement(1628006..1629685) Francisella tularensis subsp. holarctica OSU18 4307369 YP_764052.1 CDS putP NC_008369.1 1629756 1631222 R SSS family solute/sodium (Na+) symporter complement(1629756..1631222) Francisella tularensis subsp. holarctica OSU18 4307370 YP_764053.1 CDS glpX NC_008369.1 1631529 1632515 R type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II complement(1631529..1632515) Francisella tularensis subsp. holarctica OSU18 4307371 YP_764054.1 CDS FTH_1639 NC_008369.1 1632535 1633173 R alpha/beta fold family hydrolase complement(1632535..1633173) Francisella tularensis subsp. holarctica OSU18 4307372 YP_764055.1 CDS FTH_1640 NC_008369.1 1633182 1634636 R amino acid APC transporter complement(1633182..1634636) Francisella tularensis subsp. holarctica OSU18 4307373 YP_764056.1 CDS FTH_1641 NC_008369.1 1634883 1635551 R hypothetical protein complement(1634883..1635551) Francisella tularensis subsp. holarctica OSU18 4307374 YP_764057.1 CDS ftsK NC_008369.1 1635673 1638174 D cell division protein 1635673..1638174 Francisella tularensis subsp. holarctica OSU18 4307375 YP_764058.1 CDS lolA NC_008369.1 1638175 1638792 D lipoprotein releasing system subunit A, outer membrane lipoproteins carrier 1638175..1638792 Francisella tularensis subsp. holarctica OSU18 4307376 YP_764059.1 CDS FTH_1644 NC_008369.1 1639186 1639389 R conserved in Francisella genomes; hypothetical protein complement(1639186..1639389) Francisella tularensis subsp. holarctica OSU18 4307377 YP_764060.1 CDS trkH NC_008369.1 1639501 1640955 D Trk family K+ transporter membrane protein 1639501..1640955 Francisella tularensis subsp. holarctica OSU18 4307378 YP_764061.1 CDS FTH_1646 NC_008369.1 1640970 1641515 R conserved in Francisella genomes; hypothetical protein complement(1640970..1641515) Francisella tularensis subsp. holarctica OSU18 4307379 YP_764062.1 CDS FTH_1648 NC_008369.1 1642259 1642408 R hypothetical protein complement(1642259..1642408) Francisella tularensis subsp. holarctica OSU18 4307381 YP_764063.1 CDS isftu1 NC_008369.1 1643918 1644798 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(1643918..1644247,1644247..1644798) Francisella tularensis subsp. holarctica OSU18 4307384 YP_764064.1 CDS groEL NC_008369.1 1644918 1646552 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL complement(1644918..1646552) Francisella tularensis subsp. holarctica OSU18 4307385 YP_764065.1 CDS groES NC_008369.1 1646590 1646877 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(1646590..1646877) Francisella tularensis subsp. holarctica OSU18 4307386 YP_764066.1 CDS FTH_1653 NC_008369.1 1647047 1647187 R hypothetical protein complement(1647047..1647187) Francisella tularensis subsp. holarctica OSU18 4307387 YP_764067.1 CDS FTH_1654 NC_008369.1 1647210 1647554 D hypothetical protein 1647210..1647554 Francisella tularensis subsp. holarctica OSU18 4307388 YP_764068.1 CDS FTH_1655 NC_008369.1 1647647 1647778 R hypothetical protein complement(1647647..1647778) Francisella tularensis subsp. holarctica OSU18 4307390 YP_764069.1 CDS FTH_1656 NC_008369.1 1648165 1648959 D hypothetical protein 1648165..1648959 Francisella tularensis subsp. holarctica OSU18 4307391 YP_764070.1 CDS isftu1 NC_008369.1 1649010 1649890 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(1649010..1649561,1649561..1649890)) Francisella tularensis subsp. holarctica OSU18 4307392 YP_764071.1 CDS FTH_1658 NC_008369.1 1649881 1650381 D hypothetical protein 1649881..1650381 Francisella tularensis subsp. holarctica OSU18 4307393 YP_764072.1 CDS FTH_1659 NC_008369.1 1650372 1651226 R hemK methylase complement(1650372..1651226) Francisella tularensis subsp. holarctica OSU18 4307394 YP_764073.1 CDS prfA NC_008369.1 1651219 1652304 R recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 complement(1651219..1652304) Francisella tularensis subsp. holarctica OSU18 4307395 YP_764074.1 CDS hemA NC_008369.1 1652305 1653555 R catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase complement(1652305..1653555) Francisella tularensis subsp. holarctica OSU18 4307396 YP_764075.1 CDS FTH_1662 NC_008369.1 1653729 1654367 D hypothetical protein 1653729..1654367 Francisella tularensis subsp. holarctica OSU18 4307397 YP_764076.1 CDS FTH_1663 NC_008369.1 1654370 1655740 D hypothetical protein 1654370..1655740 Francisella tularensis subsp. holarctica OSU18 4307398 YP_764077.1 CDS FTH_1664 NC_008369.1 1655740 1656921 D major facilitator transporter 1655740..1656921 Francisella tularensis subsp. holarctica OSU18 4307399 YP_764078.1 CDS parE NC_008369.1 1657011 1658894 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 1657011..1658894 Francisella tularensis subsp. holarctica OSU18 4307400 YP_764079.1 CDS ampD NC_008369.1 1658942 1659466 R N-acetyl-anhydromuranmyl-L-alanine amidase complement(1658942..1659466) Francisella tularensis subsp. holarctica OSU18 4307401 YP_764080.1 CDS FTH_1667 NC_008369.1 1659540 1660166 D PAP2 family protein 1659540..1660166 Francisella tularensis subsp. holarctica OSU18 4307402 YP_764081.1 CDS FTH_1668 NC_008369.1 1660176 1660643 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(1660176..1660643) Francisella tularensis subsp. holarctica OSU18 4307403 YP_764082.1 CDS FTH_1669 NC_008369.1 1660806 1662329 D hypothetical protein 1660806..1662329 Francisella tularensis subsp. holarctica OSU18 4307404 YP_764083.1 CDS FTH_1670 NC_008369.1 1662447 1663331 D licB-like transmembrane protein 1662447..1663331 Francisella tularensis subsp. holarctica OSU18 4307405 YP_764084.1 CDS FTH_1671 NC_008369.1 1663328 1663912 R acid phosphomonoesterase; acid phosphatase complement(1663328..1663912) Francisella tularensis subsp. holarctica OSU18 4307406 YP_764085.1 CDS FTH_1672 NC_008369.1 1663917 1664768 R oxidoreductase complement(1663917..1664768) Francisella tularensis subsp. holarctica OSU18 4307407 YP_764086.1 CDS xerD NC_008369.1 1664885 1665763 R site specific recombinase XerD complement(1664885..1665763) Francisella tularensis subsp. holarctica OSU18 4307408 YP_764087.1 CDS rplS NC_008369.1 1665929 1666276 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(1665929..1666276) Francisella tularensis subsp. holarctica OSU18 4307409 YP_764088.1 CDS trmD NC_008369.1 1666276 1667040 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(1666276..1667040) Francisella tularensis subsp. holarctica OSU18 4307410 YP_764089.1 CDS rimM NC_008369.1 1667437 1667946 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(1667437..1667946) Francisella tularensis subsp. holarctica OSU18 4307411 YP_764090.1 CDS rpsP NC_008369.1 1667989 1668237 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(1667989..1668237) Francisella tularensis subsp. holarctica OSU18 4307412 YP_764091.1 CDS metK NC_008369.1 1668530 1669690 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1668530..1669690 Francisella tularensis subsp. holarctica OSU18 4307413 YP_764092.1 CDS FTH_1679 NC_008369.1 1669902 1671068 R fatty acid desaturase complement(1669902..1671068) Francisella tularensis subsp. holarctica OSU18 4307414 YP_764093.1 CDS gcp NC_008369.1 1671182 1672192 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease complement(1671182..1672192) Francisella tularensis subsp. holarctica OSU18 4307415 YP_764094.1 CDS FTH_1681 NC_008369.1 1672192 1672428 R conserved in Francisella genomes; hypothetical protein complement(1672192..1672428) Francisella tularensis subsp. holarctica OSU18 4307416 YP_764095.1 CDS rpoC NC_008369.1 1672531 1676784 R DNA-dependent RNA polymerase; DNA-directed RNA polymerase complement(1672531..1676784) Francisella tularensis subsp. holarctica OSU18 4307417 YP_764096.1 CDS rpoB NC_008369.1 1676846 1680922 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(1676846..1680922) Francisella tularensis subsp. holarctica OSU18 4307418 YP_764097.1 CDS FTH_1684 NC_008369.1 1680946 1681044 R hypothetical protein complement(1680946..1681044) Francisella tularensis subsp. holarctica OSU18 4307419 YP_764098.1 CDS rplL NC_008369.1 1681076 1681453 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(1681076..1681453) Francisella tularensis subsp. holarctica OSU18 4307420 YP_764099.1 CDS rplJ NC_008369.1 1681515 1682033 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(1681515..1682033) Francisella tularensis subsp. holarctica OSU18 4307421 YP_764100.2 CDS rplA NC_008369.1 1682203 1682898 R in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 complement(1682203..1682898) Francisella tularensis subsp. holarctica OSU18 4307422 YP_764101.1 CDS rplK NC_008369.1 1682901 1683335 R binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 complement(1682901..1683335) Francisella tularensis subsp. holarctica OSU18 4307423 YP_764102.1 CDS nusG NC_008369.1 1683404 1683937 R transcription antitermination protein NusG complement(1683404..1683937) Francisella tularensis subsp. holarctica OSU18 4307424 YP_764103.1 CDS tufA NC_008369.1 1684613 1685797 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(1684613..1685797) Francisella tularensis subsp. holarctica OSU18 4307427 YP_764104.1 CDS FTH_1693 NC_008369.1 1687676 1688173 R MscS family small conductance mechanosenstive ion channel protein complement(1687676..1688173) Francisella tularensis subsp. holarctica OSU18 4307432 YP_764105.1 CDS FTH_1694 NC_008369.1 1688151 1688864 R conserved in Francisella genomes; hypothetical protein complement(1688151..1688864) Francisella tularensis subsp. holarctica OSU18 4307433 YP_764106.1 CDS glpF NC_008369.1 1688868 1689632 R glycerol uptake facilitator protein complement(1688868..1689632) Francisella tularensis subsp. holarctica OSU18 4307434 YP_764107.1 CDS glpA NC_008369.1 1689642 1691174 R glycerol-3-phosphate dehydrogenase complement(1689642..1691174) Francisella tularensis subsp. holarctica OSU18 4307435 YP_764108.1 CDS FTH_1699 NC_008369.1 1693021 1694301 R hypothetical protein complement(1693021..1694301) Francisella tularensis subsp. holarctica OSU18 4307438 YP_764109.1 CDS qseC NC_008369.1 1695374 1696801 D sensor kinase 1695374..1696801 Francisella tularensis subsp. holarctica OSU18 4307440 YP_764110.1 CDS FTH_1702 NC_008369.1 1696798 1697679 R hypothetical protein complement(1696798..1697679) Francisella tularensis subsp. holarctica OSU18 4307441 YP_764111.1 CDS FTH_1704 NC_008369.1 1699281 1700243 D cytochrome d ubiquinol oxidase subunit II 1699281..1700243 Francisella tularensis subsp. holarctica OSU18 4307443 YP_764112.1 CDS FTH_1705 NC_008369.1 1700254 1700688 D conserved in Francisella genomes; hypothetical protein 1700254..1700688 Francisella tularensis subsp. holarctica OSU18 4307444 YP_764113.1 CDS acnA NC_008369.1 1702885 1705698 R Catalyzes the conversion of citrate to isocitrate; aconitate hydratase complement(1702885..1705698) Francisella tularensis subsp. holarctica OSU18 4307447 YP_764114.1 CDS FTH_1709 NC_008369.1 1705803 1706681 R hypothetical protein complement(1705803..1706681) Francisella tularensis subsp. holarctica OSU18 4307448 YP_764115.1 CDS FTH_1710 NC_008369.1 1706751 1707128 D hypothetical protein 1706751..1707128 Francisella tularensis subsp. holarctica OSU18 4307449 YP_764116.1 CDS hemN NC_008369.1 1707133 1708275 D coprogen oxidase; coproporphyrinogen oxidase 1707133..1708275 Francisella tularensis subsp. holarctica OSU18 4307450 YP_764117.1 CDS FTH_1712 NC_008369.1 1708272 1708748 R hypothetical protein complement(1708272..1708748) Francisella tularensis subsp. holarctica OSU18 4307451 YP_764118.1 CDS FTH_1713 NC_008369.1 1708831 1709193 R hypothetical protein complement(1708831..1709193) Francisella tularensis subsp. holarctica OSU18 4307452 YP_764119.1 CDS FTH_1714 NC_008369.1 1709171 1709785 R LysR family transcriptional regulator complement(1709171..1709785) Francisella tularensis subsp. holarctica OSU18 4307453 YP_764120.1 CDS secG NC_008369.1 1709954 1710307 R preprotein translocase subunit SecG complement(1709954..1710307) Francisella tularensis subsp. holarctica OSU18 4307455 YP_764121.1 CDS tpiA NC_008369.1 1710295 1711056 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(1710295..1711056) Francisella tularensis subsp. holarctica OSU18 4307456 YP_764122.1 CDS glmM NC_008369.1 1711059 1712390 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(1711059..1712390) Francisella tularensis subsp. holarctica OSU18 4307457 YP_764123.1 CDS apt NC_008369.1 1712401 1712928 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(1712401..1712928) Francisella tularensis subsp. holarctica OSU18 4307458 YP_764124.1 CDS sucB NC_008369.1 1712968 1714437 R dihydrolipoamide S-succinyltransferase; dihydrolipoyllysine-residue succinyltransferase complement(1712968..1714437) Francisella tularensis subsp. holarctica OSU18 4307459 YP_764125.1 CDS sucA NC_008369.1 1714463 1717276 R SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component complement(1714463..1717276) Francisella tularensis subsp. holarctica OSU18 4307460 YP_764126.1 CDS sdhB NC_008369.1 1717306 1718007 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit complement(1717306..1718007) Francisella tularensis subsp. holarctica OSU18 4307461 YP_764127.1 CDS sdhA NC_008369.1 1718025 1719818 R fumarate dehydrogenase; succinate dehydrogenase complement(1718025..1719818) Francisella tularensis subsp. holarctica OSU18 4307462 YP_764128.1 CDS sdhD NC_008369.1 1719831 1720199 R fumarate dehydrogenase; succinate dehydrogenase complement(1719831..1720199) Francisella tularensis subsp. holarctica OSU18 4307463 YP_764129.1 CDS sdhC NC_008369.1 1720175 1720648 R fumarate dehydrogenase; succinate dehydrogenase complement(1720175..1720648) Francisella tularensis subsp. holarctica OSU18 4307464 YP_764130.1 CDS gltA NC_008369.1 1720891 1722165 D (R)-citric synthase; citrate (Si)-synthase 1720891..1722165 Francisella tularensis subsp. holarctica OSU18 4307465 YP_764131.1 CDS ampG NC_008369.1 1722254 1723519 D AmpG-signal transducer; major facilitator transporter 1722254..1723519 Francisella tularensis subsp. holarctica OSU18 4307466 YP_764132.1 CDS FTH_1727 NC_008369.1 1723531 1723716 D conserved in Francisella genomes; hypothetical protein 1723531..1723716 Francisella tularensis subsp. holarctica OSU18 4307467 YP_764133.1 CDS sodB NC_008369.1 1723724 1724302 R superoxide dismutase complement(1723724..1724302) Francisella tularensis subsp. holarctica OSU18 4307468 YP_764134.1 CDS FTH_1729 NC_008369.1 1724438 1724767 D glutaredoxin-like protein 1724438..1724767 Francisella tularensis subsp. holarctica OSU18 4307469 YP_764135.1 CDS FTH_1730 NC_008369.1 1724784 1727627 R hypothetical protein complement(1724784..1727627) Francisella tularensis subsp. holarctica OSU18 4307470 YP_764136.1 CDS atpC NC_008369.1 1727838 1728275 R produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit epsilon complement(1727838..1728275) Francisella tularensis subsp. holarctica OSU18 4307471 YP_764137.1 CDS atpD NC_008369.1 1728288 1729664 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(1728288..1729664) Francisella tularensis subsp. holarctica OSU18 4307472 YP_764138.1 CDS atpG NC_008369.1 1729674 1730570 R produces ATP from ADP in the presence of a proton gradient across the membrane; the gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma complement(1729674..1730570) Francisella tularensis subsp. holarctica OSU18 4307473 YP_764139.1 CDS atpA NC_008369.1 1730585 1732126 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(1730585..1732126) Francisella tularensis subsp. holarctica OSU18 4307474 YP_764140.1 CDS atpH NC_008369.1 1732145 1732669 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(1732145..1732669) Francisella tularensis subsp. holarctica OSU18 4307475 YP_764141.1 CDS atpF NC_008369.1 1732689 1733159 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B complement(1732689..1733159) Francisella tularensis subsp. holarctica OSU18 4307476 YP_764142.1 CDS atpE NC_008369.1 1733205 1733510 R produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(1733205..1733510) Francisella tularensis subsp. holarctica OSU18 4307477 YP_764143.1 CDS atpB NC_008369.1 1733561 1734352 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(1733561..1734352) Francisella tularensis subsp. holarctica OSU18 4307478 YP_764144.1 CDS FTH_1739 NC_008369.1 1734405 1734836 R conserved in Francisella genomes; hypothetical protein complement(1734405..1734836) Francisella tularensis subsp. holarctica OSU18 4307479 YP_764145.1 CDS FTH_1740 NC_008369.1 1734913 1736217 D major facilitator transporter 1734913..1736217 Francisella tularensis subsp. holarctica OSU18 4307480 YP_764146.1 CDS rluC NC_008369.1 1736219 1737148 R pseudouridine synthase; ribosomal large subunit pseudouridine synthase C complement(1736219..1737148) Francisella tularensis subsp. holarctica OSU18 4307481 YP_764147.1 CDS FTH_1742 NC_008369.1 1737141 1738208 R ATPase complement(1737141..1738208) Francisella tularensis subsp. holarctica OSU18 4307482 YP_764148.1 CDS FTH_1743 NC_008369.1 1738211 1739509 R major facilitator transporter complement(1738211..1739509) Francisella tularensis subsp. holarctica OSU18 4307483 YP_764149.1 CDS hisS NC_008369.1 1739516 1740781 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(1739516..1740781) Francisella tularensis subsp. holarctica OSU18 4307484 YP_764150.1 CDS rbfA NC_008369.1 1740789 1741220 R ribosome-binding factor A complement(1740789..1741220) Francisella tularensis subsp. holarctica OSU18 4307485 YP_764151.1 CDS infB NC_008369.1 1741223 1743763 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(1741223..1743763) Francisella tularensis subsp. holarctica OSU18 4307486 YP_764152.1 CDS nusA NC_008369.1 1743802 1745271 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(1743802..1745271) Francisella tularensis subsp. holarctica OSU18 4307487 YP_764153.1 CDS FTH_1748 NC_008369.1 1745289 1745747 R hypothetical protein complement(1745289..1745747) Francisella tularensis subsp. holarctica OSU18 4307488 YP_764154.1 CDS hemE NC_008369.1 1745967 1747001 R catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase complement(1745967..1747001) Francisella tularensis subsp. holarctica OSU18 4307490 YP_764155.1 CDS isftu1 NC_008369.1 1748493 1749373 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(1748493..1749044,1749044..1749373)) Francisella tularensis subsp. holarctica OSU18 4307492 YP_764156.1 CDS FTH_1752 NC_008369.1 1749514 1749708 R conserved in Francisella genomes; hypothetical protein complement(1749514..1749708) Francisella tularensis subsp. holarctica OSU18 4307493 YP_764157.1 CDS nuoN NC_008369.1 1749784 1751241 R coenzyme Q reductase; NADH dehydrogenase (ubiquinone) complement(1749784..1751241) Francisella tularensis subsp. holarctica OSU18 4307494 YP_764158.1 CDS nuoM NC_008369.1 1751251 1752840 R coenzyme Q reductase; NADH dehydrogenase I subunit M complement(1751251..1752840) Francisella tularensis subsp. holarctica OSU18 4307495 YP_764159.1 CDS nuoL NC_008369.1 1752866 1754875 R coenzyme Q reductase; NADH dehydrogenase I subunit L complement(1752866..1754875) Francisella tularensis subsp. holarctica OSU18 4307496 YP_764160.1 CDS nuoK NC_008369.1 1754885 1755217 R coenzyme Q reductase; NADH dehydrogenase (ubiquinone) complement(1754885..1755217) Francisella tularensis subsp. holarctica OSU18 4307497 YP_764161.1 CDS nuoJ NC_008369.1 1755195 1755800 R coenzyme Q reductase; NADH dehydrogenase I subunit J complement(1755195..1755800) Francisella tularensis subsp. holarctica OSU18 4307498 YP_764162.1 CDS nuoI NC_008369.1 1755805 1756293 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(1755805..1756293) Francisella tularensis subsp. holarctica OSU18 4307499 YP_764163.1 CDS nuoH NC_008369.1 1756307 1757317 R coenzyme Q reductase; NADH dehydrogenase I subunit H complement(1756307..1757317) Francisella tularensis subsp. holarctica OSU18 4307500 YP_764164.1 CDS nuoG NC_008369.1 1757319 1759685 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit G complement(1757319..1759685) Francisella tularensis subsp. holarctica OSU18 4307501 YP_764165.1 CDS nuoF NC_008369.1 1759703 1760977 R coenzyme Q reductase; NADH dehydrogenase (ubiquinone) complement(1759703..1760977) Francisella tularensis subsp. holarctica OSU18 4307502 YP_764166.1 CDS nuoE NC_008369.1 1760984 1761472 R coenzyme Q reductase; NADH dehydrogenase I subunit E complement(1760984..1761472) Francisella tularensis subsp. holarctica OSU18 4307503 YP_764167.1 CDS nuoD NC_008369.1 1761482 1762735 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D complement(1761482..1762735) Francisella tularensis subsp. holarctica OSU18 4307504 YP_764168.1 CDS nuoC NC_008369.1 1762757 1763407 R coenzyme Q reductase; NADH dehydrogenase (ubiquinone) complement(1762757..1763407) Francisella tularensis subsp. holarctica OSU18 4307505 YP_764169.1 CDS nuoB NC_008369.1 1763404 1763880 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(1763404..1763880) Francisella tularensis subsp. holarctica OSU18 4307506 YP_764170.1 CDS nuoA NC_008369.1 1763871 1764269 R NADH dehydrogenase I subunit A complement(1763871..1764269) Francisella tularensis subsp. holarctica OSU18 4307507 YP_764171.1 CDS fur2 NC_008369.1 1764478 1764900 D ferric uptake regulation protein 1764478..1764900 Francisella tularensis subsp. holarctica OSU18 4307508 YP_764172.1 CDS iucA/iucC NC_008369.1 1765154 1767073 D siderophore biosynthesis IucA / IucC family protein 1765154..1767073 Francisella tularensis subsp. holarctica OSU18 4307509 YP_764173.1 CDS FTH_1769 NC_008369.1 1767080 1768342 D major facilitator superfamily multidrug resistance protein 1767080..1768342 Francisella tularensis subsp. holarctica OSU18 4307510 YP_764174.1 CDS lysA2 NC_008369.1 1768335 1769588 D DAP decarboxylase; diaminopimelate decarboxylase 1768335..1769588 Francisella tularensis subsp. holarctica OSU18 4307511 YP_764175.1 CDS FTH_1771 NC_008369.1 1769604 1770794 D major facilitator transporter 1769604..1770794 Francisella tularensis subsp. holarctica OSU18 4307512 YP_764176.1 CDS FTH_1772 NC_008369.1 1770880 1772409 D conserved in Francisella genomes; hypothetical protein 1770880..1772409 Francisella tularensis subsp. holarctica OSU18 4307513 YP_764177.1 CDS FTH_1773 NC_008369.1 1772457 1772819 D conserved in Francisella genomes; hypothetical protein 1772457..1772819 Francisella tularensis subsp. holarctica OSU18 4307514 YP_764178.1 CDS FTH_1774 NC_008369.1 1773068 1773949 D phospholipase/acyltransferase 1773068..1773949 Francisella tularensis subsp. holarctica OSU18 4306373 YP_764179.1 CDS FTH_1775 NC_008369.1 1773965 1774372 R conserved in Francisella genomes; hypothetical protein complement(1773965..1774372) Francisella tularensis subsp. holarctica OSU18 4306374 YP_764180.1 CDS gatB NC_008369.1 1774387 1775808 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(1774387..1775808) Francisella tularensis subsp. holarctica OSU18 4306375 YP_764181.1 CDS gatA NC_008369.1 1775811 1777256 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(1775811..1777256) Francisella tularensis subsp. holarctica OSU18 4306376 YP_764182.1 CDS gatC NC_008369.1 1777265 1777546 R Glu-tRNAGln amidotransferase C subunit complement(1777265..1777546) Francisella tularensis subsp. holarctica OSU18 4306377 YP_764183.1 CDS FTH_1781 NC_008369.1 1780333 1780911 R conserved in Francisella genomes; hypothetical protein complement(1780333..1780911) Francisella tularensis subsp. holarctica OSU18 4306380 YP_764184.1 CDS purB NC_008369.1 1780945 1782243 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(1780945..1782243) Francisella tularensis subsp. holarctica OSU18 4306381 YP_764185.1 CDS FTH_1784 NC_008369.1 1783429 1783827 D conserved in Francisella genomes; hypothetical protein 1783429..1783827 Francisella tularensis subsp. holarctica OSU18 4306383 YP_764186.1 CDS FTH_1785 NC_008369.1 1784070 1784852 D conserved in Francisella genomes; hypothetical protein 1784070..1784852 Francisella tularensis subsp. holarctica OSU18 4306384 YP_764187.1 CDS FTH_1786 NC_008369.1 1784870 1785730 R galactose mutarotase complement(1784870..1785730) Francisella tularensis subsp. holarctica OSU18 4306385 YP_764188.1 CDS purL NC_008369.1 1787847 1791719 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(1787847..1791719) Francisella tularensis subsp. holarctica OSU18 4306388 YP_764189.1 CDS purF NC_008369.1 1791719 1793209 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(1791719..1793209) Francisella tularensis subsp. holarctica OSU18 4306389 YP_764190.1 CDS FTH_1792 NC_008369.1 1794619 1795263 R phosphopantetheinyl transferase complement(1794619..1795263) Francisella tularensis subsp. holarctica OSU18 4306391 YP_764191.1 CDS tolC NC_008369.1 1795269 1796798 R outer membrane protein tolC complement(1795269..1796798) Francisella tularensis subsp. holarctica OSU18 4306392 YP_764192.1 CDS pcm NC_008369.1 1796807 1797427 R L-isoaspartyl protein carboxyl methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase complement(1796807..1797427) Francisella tularensis subsp. holarctica OSU18 4306393 YP_764193.1 CDS yegQ NC_008369.1 1797747 1799078 D hypothetical protein 1797747..1799078 Francisella tularensis subsp. holarctica OSU18 4306394 YP_764194.1 CDS FTH_1796 NC_008369.1 1799118 1800299 R major facilitator superfamily multidrug resistance protein complement(1799118..1800299) Francisella tularensis subsp. holarctica OSU18 4306395 YP_764195.1 CDS nhaD NC_008369.1 1800474 1801901 D NhaD family Na(+)/H(+) antiporter 1800474..1801901 Francisella tularensis subsp. holarctica OSU18 4306396 YP_764196.1 CDS FTH_1799 NC_008369.1 1803541 1805415 R APC family amino acid-polyamine-organocation transporter complement(1803541..1805415) Francisella tularensis subsp. holarctica OSU18 4306398 YP_764197.1 CDS obgE NC_008369.1 1805422 1806426 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(1805422..1806426) Francisella tularensis subsp. holarctica OSU18 4306399 YP_764198.1 CDS FTH_1801 NC_008369.1 1806502 1807698 R HAAAP family tyrosine/H(+) symporter complement(1806502..1807698) Francisella tularensis subsp. holarctica OSU18 4306400 YP_764199.1 CDS FTH_1802 NC_008369.1 1807825 1808136 D conserved in Francisella genomes; hypothetical protein 1807825..1808136 Francisella tularensis subsp. holarctica OSU18 4306401 YP_764200.1 CDS kdpC NC_008369.1 1812499 1813053 R K(+)-importing ATPase; potassium-transporting ATPase complement(1812499..1813053) Francisella tularensis subsp. holarctica OSU18 4306405 YP_764201.1 CDS kdpA NC_008369.1 1815057 1816778 R catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A complement(1815057..1816778) Francisella tularensis subsp. holarctica OSU18 4306590 YP_764202.1 CDS leuD NC_008369.1 1820331 1820900 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(1820331..1820900) Francisella tularensis subsp. holarctica OSU18 4306595 YP_764203.1 CDS FTH_1814 NC_008369.1 1820903 1822306 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(1820903..1822306) Francisella tularensis subsp. holarctica OSU18 4306596 YP_764204.1 CDS isftu1 NC_008369.1 1822584 1823464 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(1822584..1822913,1822913..1823464) Francisella tularensis subsp. holarctica OSU18 4306597 YP_764205.1 CDS FTH_1816 NC_008369.1 1823661 1824656 R conserved in Francisella genomes; hypothetical protein complement(1823661..1824656) Francisella tularensis subsp. holarctica OSU18 4306598 YP_764206.1 CDS FTH_1818 NC_008369.1 1826061 1827458 R hypothetical protein complement(1826061..1827458) Francisella tularensis subsp. holarctica OSU18 4306600 YP_764207.1 CDS blc NC_008369.1 1827622 1828140 R outer membrane lipoprotein complement(1827622..1828140) Francisella tularensis subsp. holarctica OSU18 4306601 YP_764208.1 CDS holA NC_008369.1 1828226 1829203 D DNA nucleotidyltransferase (DNA-directed); DNA polymerase III subunit delta 1828226..1829203 Francisella tularensis subsp. holarctica OSU18 4306602 YP_764209.1 CDS glnA NC_008369.1 1829323 1830360 D glutamine synthetase 1829323..1830360 Francisella tularensis subsp. holarctica OSU18 4306603 YP_764210.1 CDS glsA NC_008369.1 1830442 1831983 D L-glutamine amidohydrolase; glutaminase 1830442..1831983 Francisella tularensis subsp. holarctica OSU18 4306604 YP_764211.1 CDS FTH_1824 NC_008369.1 1832967 1833509 D conserved in Francisella genomes; hypothetical protein 1832967..1833509 Francisella tularensis subsp. holarctica OSU18 4306606 YP_764212.1 CDS lysU NC_008369.1 1833894 1835624 R lysine translase; lysyl-tRNA synthetase complement(1833894..1835624) Francisella tularensis subsp. holarctica OSU18 4306607 YP_764213.1 CDS FTH_1826 NC_008369.1 1835637 1835732 R hypothetical protein complement(1835637..1835732) Francisella tularensis subsp. holarctica OSU18 4306608 YP_764214.1 CDS prfB NC_008369.1 1835754 1836731 R peptide chain release factor 2 complement(1835754..1836731) Francisella tularensis subsp. holarctica OSU18 4306609 YP_764215.1 CDS dnaX NC_008369.1 1837004 1838641 D DNA nucleotidyltransferase (DNA-directed); DNA polymerase III subunit gamma and tau 1837004..1838641 Francisella tularensis subsp. holarctica OSU18 4306610 YP_764216.1 CDS lpxC NC_008369.1 1838655 1839515 R zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase complement(1838655..1839515) Francisella tularensis subsp. holarctica OSU18 4306611 YP_764217.1 CDS ftsZ NC_008369.1 1839538 1840683 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(1839538..1840683) Francisella tularensis subsp. holarctica OSU18 4306612 YP_764218.1 CDS ftsA NC_008369.1 1840727 1841989 R cell division protein FtsA complement(1840727..1841989) Francisella tularensis subsp. holarctica OSU18 4306613 YP_764219.1 CDS ftsQ NC_008369.1 1842091 1842774 R cell division protein FtsQ complement(1842091..1842774) Francisella tularensis subsp. holarctica OSU18 4306614 YP_764220.1 CDS ddlB NC_008369.1 1842771 1843661 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(1842771..1843661) Francisella tularensis subsp. holarctica OSU18 4306615 YP_764221.1 CDS FTH_1834 NC_008369.1 1843665 1844126 R cytosine/adenosine deaminase complement(1843665..1844126) Francisella tularensis subsp. holarctica OSU18 4306616 YP_764222.1 CDS rpsA NC_008369.1 1844220 1845944 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1844220..1845944 Francisella tularensis subsp. holarctica OSU18 4306617 YP_764223.1 CDS FTH_1836 NC_008369.1 1846061 1846603 D Sua5/YciO/YrdC family protein 1846061..1846603 Francisella tularensis subsp. holarctica OSU18 4306618 YP_764224.1 CDS FTH_1837 NC_008369.1 1846701 1847237 D hypothetical protein 1846701..1847237 Francisella tularensis subsp. holarctica OSU18 4306619 YP_764225.1 CDS FTH_1838 NC_008369.1 1847623 1848513 R putative acyltransferase complement(1847623..1848513) Francisella tularensis subsp. holarctica OSU18 4306620 YP_764226.1 CDS FTH_1842 NC_008369.1 1854004 1854786 D ABC transporter ATP-binding protein 1854004..1854786 Francisella tularensis subsp. holarctica OSU18 4306624 YP_764227.1 CDS FTH_1843 NC_008369.1 1854780 1855349 R hypothetical protein complement(1854780..1855349) Francisella tularensis subsp. holarctica OSU18 4306625 YP_764228.1 CDS FTH_1844 NC_008369.1 1855442 1856272 R hypothetical protein complement(1855442..1856272) Francisella tularensis subsp. holarctica OSU18 4306626 YP_764229.1 CDS FTH_1845 NC_008369.1 1856342 1856737 R hypothetical protein complement(1856342..1856737) Francisella tularensis subsp. holarctica OSU18 4306627 YP_764230.1 CDS isftu1 NC_008369.1 1856697 1857577 R ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase complement(join(1856697..1857248,1857248..1857577)) Francisella tularensis subsp. holarctica OSU18 4306628 YP_764231.1 CDS purH NC_008369.1 1859495 1861042 R involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase complement(1859495..1861042) Francisella tularensis subsp. holarctica OSU18 4306631 YP_764232.1 CDS purA NC_008369.1 1861219 1862505 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 1861219..1862505 Francisella tularensis subsp. holarctica OSU18 4306632 YP_764233.1 CDS hpt NC_008369.1 1862509 1863042 D guanine phosphoribosyltransferase; hypoxanthine phosphoribosyltransferase 1862509..1863042 Francisella tularensis subsp. holarctica OSU18 4306633 YP_764234.1 CDS FTH_1853 NC_008369.1 1863872 1864714 R cation ABC transporter ATP-binding protein complement(1863872..1864714) Francisella tularensis subsp. holarctica OSU18 4306635 YP_764235.1 CDS FTH_1854 NC_008369.1 1864656 1865384 R ABC transporter ATP-binding protein complement(1864656..1865384) Francisella tularensis subsp. holarctica OSU18 4306636 YP_764236.1 CDS FTH_1855 NC_008369.1 1865335 1866252 R ABC transporter ATP-binding protein complement(1865335..1866252) Francisella tularensis subsp. holarctica OSU18 4306637 YP_764237.1 CDS FTH_1857 NC_008369.1 1867664 1868128 R outer membrane lipoprotein complement(1867664..1868128) Francisella tularensis subsp. holarctica OSU18 4306639 YP_764238.1 CDS wrbA NC_008369.1 1868139 1868735 R trp repressor binding protein complement(1868139..1868735) Francisella tularensis subsp. holarctica OSU18 4306640 YP_764239.1 CDS rbn NC_008369.1 1868742 1869929 D BN family tRNA processing ribonuclease 1868742..1869929 Francisella tularensis subsp. holarctica OSU18 4306641 YP_764240.1 CDS FTH_1860 NC_008369.1 1869948 1870523 D PnuC family nicotinamide mononucleotide transporter 1869948..1870523 Francisella tularensis subsp. holarctica OSU18 4306642 YP_764241.1 CDS priA NC_008369.1 1870520 1872673 D replication factor Y; primosomal protein N' 1870520..1872673 Francisella tularensis subsp. holarctica OSU18 4306643 YP_764242.1 CDS isftu1 NC_008369.1 1872803 1873683 D ISFtu1 transposase. Member of the IS630 Tc-1 mariner family. A programmed ribosomal frameshifting motif, 5'-AAAAAAAG-3', is located 325 nt from the 5' end (a.a. 109) which enables frameshifting to produce a single ORF (this is a regulatory mechanism associated with some transposases). Alignment of the frameshifted ORF with additional members of the IS630 family, and mariner elements, shows that this transposase shares conserved residues, including a fully conserved, Asp-Glu (DE) dipeptide, and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). The conserved dipeptide is only present if the ribosomal frameshift occurs.; ISFtu1 transposase join(1872803..1873132,1873132..1873683) Francisella tularensis subsp. holarctica OSU18 4306644 YP_764243.1 CDS FTH_1864 NC_008369.1 1874518 1876197 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein complement(1874518..1876197) Francisella tularensis subsp. holarctica OSU18 4306646 YP_764244.1 CDS FTH_1865 NC_008369.1 1876410 1877651 D major facilitator transporter 1876410..1877651 Francisella tularensis subsp. holarctica OSU18 4306647 YP_764245.1 CDS FTH_1866 NC_008369.1 1877738 1877938 R conserved in Francisella genomes; hypothetical protein complement(1877738..1877938) Francisella tularensis subsp. holarctica OSU18 4306648 YP_764246.1 CDS FTH_1867 NC_008369.1 1877950 1878162 R conserved in Francisella genomes; hypothetical protein complement(1877950..1878162) Francisella tularensis subsp. holarctica OSU18 4306649 YP_764247.1 CDS FTH_1868 NC_008369.1 1878322 1879188 D zinc (Zn2+)-dependent hydrolase 1878322..1879188 Francisella tularensis subsp. holarctica OSU18 4306650 YP_764248.1 CDS pepN NC_008369.1 1882720 1885296 R amino-oligopeptidase; aminopeptidase N complement(1882720..1885296) Francisella tularensis subsp. holarctica OSU18 4306655 YP_764249.1 CDS hsp NC_008369.1 1885498 1885926 D heat shock protein 1885498..1885926 Francisella tularensis subsp. holarctica OSU18 4306656 YP_764250.1 CDS trpC/trpF NC_008369.1 1885923 1887284 R monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase complement(1885923..1887284) Francisella tularensis subsp. holarctica OSU18 4306657 YP_764251.1 CDS msrA2 NC_008369.1 1887794 1888483 R peptide Met(O) reductase; protein-methionine-S-oxide reductase complement(1887794..1888483) Francisella tularensis subsp. holarctica OSU18 4306659 YP_764252.1 CDS FTH_1878 NC_008369.1 1888567 1888935 R hypothetical protein complement(1888567..1888935) Francisella tularensis subsp. holarctica OSU18 4306660 YP_764253.1 CDS FTH_1879 NC_008369.1 1888928 1889269 R hypothetical protein complement(1888928..1889269) Francisella tularensis subsp. holarctica OSU18 4306661 YP_764254.1 CDS FTH_1880 NC_008369.1 1889338 1889739 R conserved in Francisella genomes; hypothetical protein complement(1889338..1889739) Francisella tularensis subsp. holarctica OSU18 4306662 YP_764255.1 CDS trpD NC_008369.1 1889840 1890865 R Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase complement(1889840..1890865) Francisella tularensis subsp. holarctica OSU18 4306663 YP_764256.1 CDS trpG2 NC_008369.1 1890850 1891428 R glutamine amido-transferase; anthranilate synthase component II complement(1890850..1891428) Francisella tularensis subsp. holarctica OSU18 4306664 YP_764257.1 CDS trpE2 NC_008369.1 1891432 1892976 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1891432..1892976) Francisella tularensis subsp. holarctica OSU18 4306665 YP_764258.1 CDS trpR NC_008369.1 1892985 1893272 R trp operon repressor complement(1892985..1893272) Francisella tularensis subsp. holarctica OSU18 4306666 YP_764259.1 CDS cafA2 NC_008369.1 1893746 1895242 R ribonuclease G complement(1893746..1895242) Francisella tularensis subsp. holarctica OSU18 4306669 FTH_t0001 tRNA FTH_t0001 NC_008369.1 125971 126047 D tRNA-Ile 125971..126047 Francisella tularensis subsp. holarctica OSU18 4307260 FTH_t0002 tRNA FTH_t0002 NC_008369.1 126061 126138 D tRNA-Ala 126061..126138 Francisella tularensis subsp. holarctica OSU18 4307261 FTH_t0003 tRNA FTH_t0003 NC_008369.1 158189 158265 D tRNA-Gln 158189..158265 Francisella tularensis subsp. holarctica OSU18 4307290 FTH_t0004 tRNA FTH_t0004 NC_008369.1 223030 223105 D tRNA-Glu 223030..223105 Francisella tularensis subsp. holarctica OSU18 4308040 FTH_t0005 tRNA FTH_t0005 NC_008369.1 294779 294853 R tRNA-Gly complement(294779..294853) Francisella tularensis subsp. holarctica OSU18 4307617 FTH_t0006 tRNA FTH_t0006 NC_008369.1 294867 294945 R tRNA-Arg complement(294867..294945) Francisella tularensis subsp. holarctica OSU18 4307618 FTH_t0007 tRNA FTH_t0007 NC_008369.1 329351 329442 D tRNA-Ser 329351..329442 Francisella tularensis subsp. holarctica OSU18 4307656 FTH_t0008 tRNA FTH_t0008 NC_008369.1 417875 417966 D tRNA-Ser 417875..417966 Francisella tularensis subsp. holarctica OSU18 4306486 FTH_t0009 tRNA FTH_t0009 NC_008369.1 417994 418069 D tRNA-Val 417994..418069 Francisella tularensis subsp. holarctica OSU18 4306487 FTH_t0010 tRNA FTH_t0010 NC_008369.1 420910 420986 D tRNA-Ile 420910..420986 Francisella tularensis subsp. holarctica OSU18 4306490 FTH_t0011 tRNA FTH_t0011 NC_008369.1 421000 421077 D tRNA-Ala 421000..421077 Francisella tularensis subsp. holarctica OSU18 4306491 FTH_t0012 tRNA FTH_t0012 NC_008369.1 530661 530739 R tRNA-Met complement(530661..530739) Francisella tularensis subsp. holarctica OSU18 4307955 FTH_t0013 tRNA FTH_t0013 NC_008369.1 610728 610816 D tRNA-Leu 610728..610816 Francisella tularensis subsp. holarctica OSU18 4308122 FTH_t0014 tRNA FTH_t0014 NC_008369.1 640202 640279 R tRNA-Asn complement(640202..640279) Francisella tularensis subsp. holarctica OSU18 4308160 FTH_t0015 tRNA FTH_t0015 NC_008369.1 647529 647605 D tRNA-Gly 647529..647605 Francisella tularensis subsp. holarctica OSU18 4308169 FTH_t0016 tRNA FTH_t0016 NC_008369.1 647620 647693 D tRNA-Cys 647620..647693 Francisella tularensis subsp. holarctica OSU18 4308170 FTH_t0017 tRNA FTH_t0017 NC_008369.1 647699 647787 D tRNA-Leu 647699..647787 Francisella tularensis subsp. holarctica OSU18 4308171 FTH_t0018 tRNA FTH_t0018 NC_008369.1 1124896 1124972 D tRNA-Ile 1124896..1124972 Francisella tularensis subsp. holarctica OSU18 4306790 FTH_t0019 tRNA FTH_t0019 NC_008369.1 1124986 1125063 D tRNA-Ala 1124986..1125063 Francisella tularensis subsp. holarctica OSU18 4306791 FTH_t0020 tRNA FTH_t0020 NC_008369.1 1233060 1233138 D tRNA-Val 1233060..1233138 Francisella tularensis subsp. holarctica OSU18 4307548 FTH_t0021 tRNA FTH_t0021 NC_008369.1 1296554 1296643 D tRNA-Ser 1296554..1296643 Francisella tularensis subsp. holarctica OSU18 4307725 FTH_t0022 tRNA FTH_t0022 NC_008369.1 1350968 1351052 R tRNA-Leu complement(1350968..1351052) Francisella tularensis subsp. holarctica OSU18 4307784 FTH_t0023 tRNA FTH_t0023 NC_008369.1 1351057 1351134 R tRNA-His complement(1351057..1351134) Francisella tularensis subsp. holarctica OSU18 4307785 FTH_t0024 tRNA FTH_t0024 NC_008369.1 1351160 1351238 R tRNA-Arg complement(1351160..1351238) Francisella tularensis subsp. holarctica OSU18 4307786 FTH_t0025 tRNA FTH_t0025 NC_008369.1 1351245 1351323 R tRNA-Pro complement(1351245..1351323) Francisella tularensis subsp. holarctica OSU18 4307787 FTH_t0026 tRNA FTH_t0026 NC_008369.1 1351339 1351416 R tRNA-Phe complement(1351339..1351416) Francisella tularensis subsp. holarctica OSU18 4307788 FTH_t0027 tRNA FTH_t0027 NC_008369.1 1413904 1413979 R tRNA-Lys complement(1413904..1413979) Francisella tularensis subsp. holarctica OSU18 4307850 FTH_t0028 tRNA FTH_t0028 NC_008369.1 1462750 1462825 R tRNA-Val complement(1462750..1462825) Francisella tularensis subsp. holarctica OSU18 4307891 FTH_t0029 tRNA FTH_t0029 NC_008369.1 1642415 1642493 D tRNA-Met 1642415..1642493 Francisella tularensis subsp. holarctica OSU18 4307382 FTH_t0030 tRNA FTH_t0030 NC_008369.1 1647565 1647640 D tRNA-Arg 1647565..1647640 Francisella tularensis subsp. holarctica OSU18 4307389 FTH_t0031 tRNA FTH_t0031 NC_008369.1 1684517 1684594 D tRNA-Trp 1684517..1684594 Francisella tularensis subsp. holarctica OSU18 4307426 FTH_t0032 tRNA FTH_t0032 NC_008369.1 1685842 1685917 R tRNA-Thr complement(1685842..1685917) Francisella tularensis subsp. holarctica OSU18 4307428 FTH_t0033 tRNA FTH_t0033 NC_008369.1 1685946 1686019 R tRNA-Gly complement(1685946..1686019) Francisella tularensis subsp. holarctica OSU18 4307429 FTH_t0034 tRNA FTH_t0034 NC_008369.1 1686021 1686105 R tRNA-Tyr complement(1686021..1686105) Francisella tularensis subsp. holarctica OSU18 4307430 FTH_t0035 tRNA FTH_t0035 NC_008369.1 1709859 1709946 R tRNA-Leu complement(1709859..1709946) Francisella tularensis subsp. holarctica OSU18 4307454 FTH_t0036 tRNA FTH_t0036 NC_008369.1 1745817 1745893 R tRNA-Met complement(1745817..1745893) Francisella tularensis subsp. holarctica OSU18 4307489 FTH_t0037 tRNA FTH_t0037 NC_008369.1 1893527 1893605 R tRNA-Asp complement(1893527..1893605) Francisella tularensis subsp. holarctica OSU18 4306667 FTH_t0038 tRNA FTH_t0038 NC_008369.1 1893609 1893684 R tRNA-Thr complement(1893609..1893684) Francisella tularensis subsp. holarctica OSU18 4306668 FTH_r0001 rRNA rrs1 NC_008369.1 124352 125875 D 16S ribosomal RNA 124352..125875 Francisella tularensis subsp. holarctica OSU18 4307259 FTH_r0002 rRNA rrl1 NC_008369.1 126211 129073 D 23S ribosomal RNA 126211..129073 Francisella tularensis subsp. holarctica OSU18 4307262 FTH_r0003 rRNA rrf1 NC_008369.1 129124 129238 D 5S ribosomal RNA 129124..129238 Francisella tularensis subsp. holarctica OSU18 4307263 FTH_r0004 rRNA rrs2 NC_008369.1 419291 420814 D 16S ribosomal RNA 419291..420814 Francisella tularensis subsp. holarctica OSU18 4306489 FTH_r0005 rRNA rrl2 NC_008369.1 421150 424011 D 23S ribosomal RNA 421150..424011 Francisella tularensis subsp. holarctica OSU18 4306492 FTH_r0006 rRNA FTH_r0006 NC_008369.1 424062 424176 D 5S ribosomal RNA 424062..424176 Francisella tularensis subsp. holarctica OSU18 4306493 FTH_r0007 rRNA rrf2 NC_008369.1 453764 453882 D 5S ribosomal RNA 453764..453882 Francisella tularensis subsp. holarctica OSU18 4306526 FTH_r0008 rRNA FTH_r0008 NC_008369.1 1123277 1124800 D 16S ribosomal RNA 1123277..1124800 Francisella tularensis subsp. holarctica OSU18 4306789 FTH_r0009 rRNA FTH_r0009 NC_008369.1 1125136 1127997 D 23S ribosomal RNA 1125136..1127997 Francisella tularensis subsp. holarctica OSU18 4306792 FTH_r0010 rRNA FTH_r0010 NC_008369.1 1128048 1128162 D 5S ribosomal RNA 1128048..1128162 Francisella tularensis subsp. holarctica OSU18 4306793