-- dump date 20140619_095356 -- class Genbank::misc_feature -- table misc_feature_note -- id note 393011000001 Souce of Bacteria: Dr. Rebecca Morton at Oklahoma State University, mortonr@okstate.edu 393011000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 393011000003 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 393011000004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393011000005 Walker A motif; other site 393011000006 ATP binding site [chemical binding]; other site 393011000007 Walker B motif; other site 393011000008 arginine finger; other site 393011000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 393011000010 DnaA box-binding interface [nucleotide binding]; other site 393011000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 393011000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 393011000013 putative DNA binding surface [nucleotide binding]; other site 393011000014 dimer interface [polypeptide binding]; other site 393011000015 beta-clamp/clamp loader binding surface; other site 393011000016 beta-clamp/translesion DNA polymerase binding surface; other site 393011000017 pseudogene of probable MFS family major facilitator transporter 393011000018 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011000019 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011000020 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011000021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011000022 potassium/proton antiporter; Reviewed; Region: PRK05326 393011000023 indolepyruvate decarboxylase; indole-3-pyruvate decarboxylase 393011000024 pseudogene of probable ferredoxin 393011000025 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 393011000026 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 393011000027 tandem repeat interface [polypeptide binding]; other site 393011000028 oligomer interface [polypeptide binding]; other site 393011000029 active site residues [active] 393011000030 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 393011000031 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 393011000032 preprotein translocase subunit SecB; Provisional; Region: PRK13031 393011000033 SecA binding site; other site 393011000034 Preprotein binding site; other site 393011000035 recombinase A; Provisional; Region: recA; PRK09354 393011000036 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 393011000037 hexamer interface [polypeptide binding]; other site 393011000038 Walker A motif; other site 393011000039 ATP binding site [chemical binding]; other site 393011000040 Walker B motif; other site 393011000041 recombination regulator RecX; Reviewed; Region: recX; PRK00117 393011000042 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 393011000043 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 393011000044 dimer interface [polypeptide binding]; other site 393011000045 ssDNA binding site [nucleotide binding]; other site 393011000046 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393011000047 propionate/acetate kinase; Provisional; Region: PRK12379 393011000048 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 393011000049 phosphate acetyltransferase; Reviewed; Region: PRK05632 393011000050 DRTGG domain; Region: DRTGG; pfam07085 393011000051 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 393011000052 pseudogene of succinate-semialdehyde dehydrogenase 393011000053 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011000054 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011000055 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011000056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011000057 pseudogene of possible glycosyltransferase 393011000058 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 393011000059 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 393011000060 dimer interface [polypeptide binding]; other site 393011000061 anticodon binding site; other site 393011000062 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 393011000063 homodimer interface [polypeptide binding]; other site 393011000064 motif 1; other site 393011000065 active site 393011000066 motif 2; other site 393011000067 GAD domain; Region: GAD; pfam02938 393011000068 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 393011000069 active site 393011000070 motif 3; other site 393011000071 metabolite-proton symporter; Region: 2A0106; TIGR00883 393011000072 pseudogene of probable succinate-semialdehyde dehydrogenase 393011000073 pseudogene of ISFtu1 transposase 393011000074 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 393011000075 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 393011000076 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 393011000077 pseudogene of 3-hydroxyisobutyrate dehydrogenase 393011000078 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 393011000079 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 393011000080 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 393011000081 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 393011000082 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 393011000083 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 393011000084 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 393011000085 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 393011000086 ATP-grasp domain; Region: ATP-grasp_4; cl17255 393011000087 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 393011000088 substrate binding site [chemical binding]; other site 393011000089 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 393011000090 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 393011000091 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 393011000092 catalytic site [active] 393011000093 subunit interface [polypeptide binding]; other site 393011000094 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 393011000095 catalytic core [active] 393011000096 thiopurine S-methyltransferase; Reviewed; Region: PRK13256 393011000097 dihydroorotase; Reviewed; Region: PRK09236 393011000098 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 393011000099 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 393011000100 active site 393011000101 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 393011000102 pseudogene of conserved hypothetical protein 393011000103 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 393011000104 HlyD family secretion protein; Region: HlyD; pfam00529 393011000105 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 393011000106 HlyD family secretion protein; Region: HlyD_3; pfam13437 393011000107 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 393011000108 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393011000109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393011000110 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 393011000111 dimerization interface [polypeptide binding]; other site 393011000112 pseudogene of conserved hypothetical protein 393011000113 pseudogene of ISFtu2 transposase 393011000114 Chorismate mutase type II; Region: CM_2; smart00830 393011000115 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 393011000116 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 393011000117 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 393011000118 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 393011000119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 393011000120 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 393011000121 active site 393011000122 dimer interface [polypeptide binding]; other site 393011000123 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 393011000124 phosphate binding site [ion binding]; other site 393011000125 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 393011000126 prephenate dehydrogenase; Provisional; Region: PRK06444 393011000127 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 393011000128 putative active site [active] 393011000129 dimerization interface [polypeptide binding]; other site 393011000130 putative tRNAtyr binding site [nucleotide binding]; other site 393011000131 pseudogene of ABC superfamily ATP binding cassette transporter, ABC protein 393011000132 beta-fructofuranosidase; beta-fructosidase 393011000133 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011000134 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011000135 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011000136 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011000137 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 393011000138 putative FMN binding site [chemical binding]; other site 393011000139 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 393011000140 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 393011000141 aromatic amino acid transport protein; Region: araaP; TIGR00837 393011000142 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 393011000143 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 393011000144 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 393011000145 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 393011000146 catalytic residue [active] 393011000147 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 393011000148 pseudogene of possible transcription regulator 393011000149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011000150 putative substrate translocation pore; other site 393011000151 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 393011000152 pseudogene of conserved hypothetical protein 393011000153 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 393011000154 dimer interface [polypeptide binding]; other site 393011000155 active site 393011000156 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 393011000157 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 393011000158 GTP-binding protein LepA; Provisional; Region: PRK05433 393011000159 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 393011000160 G1 box; other site 393011000161 putative GEF interaction site [polypeptide binding]; other site 393011000162 GTP/Mg2+ binding site [chemical binding]; other site 393011000163 Switch I region; other site 393011000164 G2 box; other site 393011000165 G3 box; other site 393011000166 Switch II region; other site 393011000167 G4 box; other site 393011000168 G5 box; other site 393011000169 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 393011000170 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 393011000171 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 393011000172 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 393011000173 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 393011000174 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 393011000175 active site 393011000176 catalytic residues [active] 393011000177 metal binding site [ion binding]; metal-binding site 393011000178 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 393011000179 homopentamer interface [polypeptide binding]; other site 393011000180 active site 393011000181 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 393011000182 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 393011000183 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 393011000184 dimerization interface [polypeptide binding]; other site 393011000185 active site 393011000186 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 393011000187 Lumazine binding domain; Region: Lum_binding; pfam00677 393011000188 Lumazine binding domain; Region: Lum_binding; pfam00677 393011000189 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 393011000190 catalytic motif [active] 393011000191 Zn binding site [ion binding]; other site 393011000192 RibD C-terminal domain; Region: RibD_C; cl17279 393011000193 pseudogene of ISFtu2 transposase 393011000194 pseudogene of ISFtu1 transposase 393011000195 pseudogene of MFS family major facilitator transporter 393011000196 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 393011000197 pseudogene of probable rieske 2Fe-2S dioxygenase 393011000198 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854 393011000199 hypothetical protein; Provisional; Region: PRK05421 393011000200 putative catalytic site [active] 393011000201 putative metal binding site [ion binding]; other site 393011000202 putative phosphate binding site [ion binding]; other site 393011000203 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 393011000204 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 393011000205 putative acyl-acceptor binding pocket; other site 393011000206 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 393011000207 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 393011000208 putative acyl-acceptor binding pocket; other site 393011000209 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 393011000210 4Fe-4S binding domain; Region: Fer4; cl02805 393011000211 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 393011000212 pseudogene of O-methyltransferase 393011000213 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 393011000214 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 393011000215 ATP-grasp domain; Region: ATP-grasp; pfam02222 393011000216 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 393011000217 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 393011000218 active site 393011000219 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 393011000220 Clp amino terminal domain; Region: Clp_N; pfam02861 393011000221 Clp amino terminal domain; Region: Clp_N; pfam02861 393011000222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393011000223 Walker A motif; other site 393011000224 ATP binding site [chemical binding]; other site 393011000225 Walker B motif; other site 393011000226 arginine finger; other site 393011000227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393011000228 Walker A motif; other site 393011000229 ATP binding site [chemical binding]; other site 393011000230 Walker B motif; other site 393011000231 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 393011000232 pseudogene of NMN family nicotinamide mononucleotide uptake permease PnuC 393011000233 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 393011000234 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 393011000235 substrate binding site [chemical binding]; other site 393011000236 active site 393011000237 catalytic residues [active] 393011000238 heterodimer interface [polypeptide binding]; other site 393011000239 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 393011000240 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 393011000241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393011000242 catalytic residue [active] 393011000243 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 393011000244 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 393011000245 active site 393011000246 Zn binding site [ion binding]; other site 393011000247 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 393011000248 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 393011000249 Cl- selectivity filter; other site 393011000250 Cl- binding residues [ion binding]; other site 393011000251 pore gating glutamate residue; other site 393011000252 dimer interface [polypeptide binding]; other site 393011000253 H+/Cl- coupling transport residue; other site 393011000254 pseudogene of conserved hypothetical protein 393011000255 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 393011000256 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 393011000257 pseudogene of NMN family nicotinamide mononucleotide uptake permease PnuC; PnuC family transporter 393011000258 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011000259 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011000260 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011000261 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011000262 pseudogene of MFS family major facilitator transporter 393011000263 pseudogene of conserved protein PdpD; PdpD2 393011000264 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 393011000265 Protein of unknown function (DUF877); Region: DUF877; pfam05943 393011000266 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 393011000267 Intracellular growth locus C protein; Region: IglC; pfam11550 393011000268 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 393011000269 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 393011000270 pseduogene of conserved hypothetical protein 393011000271 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 393011000272 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 393011000273 NAD binding site [chemical binding]; other site 393011000274 pseudogene of ISFtu1 transposase 393011000275 2-isopropylmalate synthase; alpha-IPM synthetase 393011000276 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 393011000277 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 393011000278 homodimer interface [polypeptide binding]; other site 393011000279 substrate-cofactor binding pocket; other site 393011000280 catalytic residue [active] 393011000281 pyruvate phosphate dikinase; Provisional; Region: PRK09279 393011000282 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 393011000283 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 393011000284 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 393011000285 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 393011000286 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 393011000287 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 393011000288 G1 box; other site 393011000289 GTP/Mg2+ binding site [chemical binding]; other site 393011000290 Switch I region; other site 393011000291 G2 box; other site 393011000292 G3 box; other site 393011000293 Switch II region; other site 393011000294 G4 box; other site 393011000295 G5 box; other site 393011000296 Nucleoside recognition; Region: Gate; pfam07670 393011000297 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 393011000298 Nucleoside recognition; Region: Gate; pfam07670 393011000299 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011000300 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011000301 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011000302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011000303 pseudogene of conserved hypothetical protein 393011000304 pseudogene of conserved hypothetical protein 393011000305 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 393011000306 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 393011000307 RNB domain; Region: RNB; pfam00773 393011000308 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 393011000309 putative hydrolase; Provisional; Region: PRK11460 393011000310 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 393011000311 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 393011000312 domain interfaces; other site 393011000313 active site 393011000314 camphor resistance protein CrcB; Provisional; Region: PRK14226 393011000315 Zinc-finger domain; Region: zf-CHCC; cl01821 393011000316 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 393011000317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393011000318 dimer interface [polypeptide binding]; other site 393011000319 conserved gate region; other site 393011000320 putative PBP binding loops; other site 393011000321 ABC-ATPase subunit interface; other site 393011000322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393011000323 dimer interface [polypeptide binding]; other site 393011000324 conserved gate region; other site 393011000325 putative PBP binding loops; other site 393011000326 ABC-ATPase subunit interface; other site 393011000327 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 393011000328 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 393011000329 Walker A/P-loop; other site 393011000330 ATP binding site [chemical binding]; other site 393011000331 Q-loop/lid; other site 393011000332 ABC transporter signature motif; other site 393011000333 Walker B; other site 393011000334 D-loop; other site 393011000335 H-loop/switch region; other site 393011000336 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 393011000337 pseudogene of conserved hypothetical protein 393011000338 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 393011000339 TrkA-N domain; Region: TrkA_N; pfam02254 393011000340 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 393011000341 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 393011000342 trimer interface [polypeptide binding]; other site 393011000343 putative metal binding site [ion binding]; other site 393011000344 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 393011000345 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 393011000346 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 393011000347 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011000348 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011000349 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011000350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011000351 pseudogene of possible cytochrome b561 393011000352 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 393011000353 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 393011000354 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 393011000355 phospholipase C; clostridium oedematiens beta- and gamma-toxins 393011000356 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 393011000357 LamB/YcsF family protein; Provisional; Region: PRK05406 393011000358 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 393011000359 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 393011000360 pseudogene of MFS family major facilitator transporter 393011000361 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011000362 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011000363 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011000364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011000365 fragment of conserved hypothetical protein 393011000366 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 393011000367 Ligand Binding Site [chemical binding]; other site 393011000368 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 393011000369 Ligand Binding Site [chemical binding]; other site 393011000370 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 393011000371 PLD-like domain; Region: PLDc_2; pfam13091 393011000372 putative homodimer interface [polypeptide binding]; other site 393011000373 putative active site [active] 393011000374 catalytic site [active] 393011000375 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 393011000376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393011000377 ATP binding site [chemical binding]; other site 393011000378 putative Mg++ binding site [ion binding]; other site 393011000379 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393011000380 nucleotide binding region [chemical binding]; other site 393011000381 ATP-binding site [chemical binding]; other site 393011000382 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 393011000383 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 393011000384 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 393011000385 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 393011000386 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 393011000387 Mitochondrial PGP phosphatase; Region: PGP_phosphatase; pfam09419 393011000388 Predicted methyltransferases [General function prediction only]; Region: COG0313 393011000389 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 393011000390 putative SAM binding site [chemical binding]; other site 393011000391 putative homodimer interface [polypeptide binding]; other site 393011000392 pseudogene of UDP-N-acetylmuramate--L-alanine ligase; alanine-adding enzyme 393011000393 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 393011000394 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 393011000395 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 393011000396 shikimate binding site; other site 393011000397 NAD(P) binding site [chemical binding]; other site 393011000398 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 393011000399 Ribonuclease P; Region: Ribonuclease_P; pfam00825 393011000400 hypothetical protein; Provisional; Region: PRK14375 393011000401 membrane protein insertase; Provisional; Region: PRK01318 393011000402 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 393011000403 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 393011000404 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 393011000405 putative acyl-acceptor binding pocket; other site 393011000406 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 393011000407 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 393011000408 putative acyl-acceptor binding pocket; other site 393011000409 elongation factor P; Validated; Region: PRK00529 393011000410 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 393011000411 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 393011000412 RNA binding site [nucleotide binding]; other site 393011000413 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 393011000414 RNA binding site [nucleotide binding]; other site 393011000415 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 393011000416 catalytic site [active] 393011000417 putative active site [active] 393011000418 putative substrate binding site [chemical binding]; other site 393011000419 dimer interface [polypeptide binding]; other site 393011000420 pseudogene of conserved hypothetical protein 393011000421 pseudogene of ISFtu1 transposase 393011000422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011000423 putative substrate translocation pore; other site 393011000424 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 393011000425 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 393011000426 substrate binding pocket [chemical binding]; other site 393011000427 membrane-bound complex binding site; other site 393011000428 hinge residues; other site 393011000429 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 393011000430 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 393011000431 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 393011000432 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 393011000433 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 393011000434 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 393011000435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011000436 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393011000437 putative substrate translocation pore; other site 393011000438 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 393011000439 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 393011000440 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 393011000441 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 393011000442 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 393011000443 D-pathway; other site 393011000444 Putative ubiquinol binding site [chemical binding]; other site 393011000445 Low-spin heme (heme b) binding site [chemical binding]; other site 393011000446 Putative water exit pathway; other site 393011000447 Binuclear center (heme o3/CuB) [ion binding]; other site 393011000448 K-pathway; other site 393011000449 Putative proton exit pathway; other site 393011000450 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 393011000451 Subunit I/III interface [polypeptide binding]; other site 393011000452 Subunit III/IV interface [polypeptide binding]; other site 393011000453 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 393011000454 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 393011000455 UbiA prenyltransferase family; Region: UbiA; pfam01040 393011000456 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 393011000457 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 393011000458 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 393011000459 trimer interface [polypeptide binding]; other site 393011000460 active site 393011000461 UDP-GlcNAc binding site [chemical binding]; other site 393011000462 lipid binding site [chemical binding]; lipid-binding site 393011000463 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 393011000464 pyridoxamine kinase; Validated; Region: PRK05756 393011000465 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 393011000466 dimer interface [polypeptide binding]; other site 393011000467 pyridoxal binding site [chemical binding]; other site 393011000468 ATP binding site [chemical binding]; other site 393011000469 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 393011000470 MoxR-like ATPases [General function prediction only]; Region: COG0714 393011000471 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 393011000472 Walker A motif; other site 393011000473 ATP binding site [chemical binding]; other site 393011000474 Walker B motif; other site 393011000475 arginine finger; other site 393011000476 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 393011000477 Protein of unknown function DUF58; Region: DUF58; pfam01882 393011000478 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 393011000479 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 393011000480 metal ion-dependent adhesion site (MIDAS); other site 393011000481 hypothetical protein; Provisional; Region: PRK13685 393011000482 von Willebrand factor type A domain; Region: VWA_2; pfam13519 393011000483 metal ion-dependent adhesion site (MIDAS); other site 393011000484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393011000485 Tetratricopeptide repeat; Region: TPR_16; pfam13432 393011000486 TPR motif; other site 393011000487 binding surface 393011000488 Oxygen tolerance; Region: BatD; pfam13584 393011000489 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 393011000490 putative substrate binding pocket [chemical binding]; other site 393011000491 AC domain interface; other site 393011000492 catalytic triad [active] 393011000493 AB domain interface; other site 393011000494 interchain disulfide; other site 393011000495 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 393011000496 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 393011000497 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 393011000498 active site 393011000499 HIGH motif; other site 393011000500 nucleotide binding site [chemical binding]; other site 393011000501 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 393011000502 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 393011000503 active site 393011000504 KMSKS motif; other site 393011000505 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 393011000506 tRNA binding surface [nucleotide binding]; other site 393011000507 anticodon binding site; other site 393011000508 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 393011000509 1-deoxy-D-xylulose-5-phosphate synthase; Region: PLN02225 393011000510 pseudogene of conserved hypothetical protein 393011000511 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 393011000512 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 393011000513 phosphate binding site [ion binding]; other site 393011000514 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 393011000515 dimer interface [polypeptide binding]; other site 393011000516 FMN binding site [chemical binding]; other site 393011000517 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 393011000518 nudix motif; other site 393011000519 fumarate hydratase; Reviewed; Region: fumC; PRK00485 393011000520 Class II fumarases; Region: Fumarase_classII; cd01362 393011000521 active site 393011000522 tetramer interface [polypeptide binding]; other site 393011000523 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 393011000524 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 393011000525 HIGH motif; other site 393011000526 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 393011000527 active site 393011000528 KMSKS motif; other site 393011000529 pseudogene of conserved hypothetical protein 393011000530 pseudogene of ISFtu2 transposase 393011000531 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 393011000532 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 393011000533 Amidinotransferase; Region: Amidinotransf; pfam02274 393011000534 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 393011000535 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 393011000536 folate binding site [chemical binding]; other site 393011000537 NADP+ binding site [chemical binding]; other site 393011000538 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 393011000539 rRNA interaction site [nucleotide binding]; other site 393011000540 S8 interaction site; other site 393011000541 putative laminin-1 binding site; other site 393011000542 elongation factor Ts; Provisional; Region: tsf; PRK09377 393011000543 UBA/TS-N domain; Region: UBA; pfam00627 393011000544 Elongation factor TS; Region: EF_TS; pfam00889 393011000545 Elongation factor TS; Region: EF_TS; pfam00889 393011000546 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 393011000547 putative nucleotide binding site [chemical binding]; other site 393011000548 uridine monophosphate binding site [chemical binding]; other site 393011000549 homohexameric interface [polypeptide binding]; other site 393011000550 ribosome recycling factor; Reviewed; Region: frr; PRK00083 393011000551 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 393011000552 hinge region; other site 393011000553 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 393011000554 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 393011000555 catalytic residue [active] 393011000556 putative FPP diphosphate binding site; other site 393011000557 putative FPP binding hydrophobic cleft; other site 393011000558 dimer interface [polypeptide binding]; other site 393011000559 putative IPP diphosphate binding site; other site 393011000560 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 393011000561 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 393011000562 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 393011000563 trimer interface [polypeptide binding]; other site 393011000564 active site 393011000565 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 393011000566 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 393011000567 S17 interaction site [polypeptide binding]; other site 393011000568 S8 interaction site; other site 393011000569 16S rRNA interaction site [nucleotide binding]; other site 393011000570 streptomycin interaction site [chemical binding]; other site 393011000571 23S rRNA interaction site [nucleotide binding]; other site 393011000572 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 393011000573 30S ribosomal protein S7; Validated; Region: PRK05302 393011000574 elongation factor G; Reviewed; Region: PRK00007 393011000575 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 393011000576 G1 box; other site 393011000577 putative GEF interaction site [polypeptide binding]; other site 393011000578 GTP/Mg2+ binding site [chemical binding]; other site 393011000579 Switch I region; other site 393011000580 G2 box; other site 393011000581 G3 box; other site 393011000582 Switch II region; other site 393011000583 G4 box; other site 393011000584 G5 box; other site 393011000585 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 393011000586 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 393011000587 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 393011000588 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 393011000589 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 393011000590 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 393011000591 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 393011000592 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 393011000593 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 393011000594 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 393011000595 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 393011000596 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 393011000597 putative translocon binding site; other site 393011000598 protein-rRNA interface [nucleotide binding]; other site 393011000599 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 393011000600 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 393011000601 G-X-X-G motif; other site 393011000602 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 393011000603 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 393011000604 23S rRNA interface [nucleotide binding]; other site 393011000605 5S rRNA interface [nucleotide binding]; other site 393011000606 putative antibiotic binding site [chemical binding]; other site 393011000607 L25 interface [polypeptide binding]; other site 393011000608 L27 interface [polypeptide binding]; other site 393011000609 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 393011000610 23S rRNA interface [nucleotide binding]; other site 393011000611 putative translocon interaction site; other site 393011000612 signal recognition particle (SRP54) interaction site; other site 393011000613 L23 interface [polypeptide binding]; other site 393011000614 trigger factor interaction site; other site 393011000615 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 393011000616 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 393011000617 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 393011000618 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 393011000619 RNA binding site [nucleotide binding]; other site 393011000620 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 393011000621 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 393011000622 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 393011000623 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 393011000624 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 393011000625 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 393011000626 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 393011000627 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 393011000628 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 393011000629 23S rRNA interface [nucleotide binding]; other site 393011000630 L21e interface [polypeptide binding]; other site 393011000631 5S rRNA interface [nucleotide binding]; other site 393011000632 L27 interface [polypeptide binding]; other site 393011000633 L5 interface [polypeptide binding]; other site 393011000634 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 393011000635 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 393011000636 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 393011000637 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 393011000638 23S rRNA binding site [nucleotide binding]; other site 393011000639 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 393011000640 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 393011000641 SecY translocase; Region: SecY; pfam00344 393011000642 pseudogene of ribosomal protein L36 393011000643 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 393011000644 30S ribosomal protein S13; Region: bact_S13; TIGR03631 393011000645 30S ribosomal protein S11; Validated; Region: PRK05309 393011000646 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 393011000647 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 393011000648 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393011000649 RNA binding surface [nucleotide binding]; other site 393011000650 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 393011000651 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 393011000652 alphaNTD homodimer interface [polypeptide binding]; other site 393011000653 alphaNTD - beta interaction site [polypeptide binding]; other site 393011000654 alphaNTD - beta' interaction site [polypeptide binding]; other site 393011000655 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 393011000656 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 393011000657 fragment of conserved hypothetical protein 393011000658 pseudogene of ISFtu1 transposase 393011000659 pseudogene of ISFtu2 transposase 393011000660 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 393011000661 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011000662 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011000663 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011000664 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011000665 glutamate dehydrogenase (NADP(+)); glutamic dehydrogenase 393011000666 pseudogene of ISFtu1 transposase 393011000667 pseudogene of chaperone HtpG; hsp90 393011000668 glutamate dehydrogenase (NADP(+)); glutamic dehydrogenase 393011000669 pseudogene of ISFtu1 transposase 393011000670 glutamate dehydrogenase; Provisional; Region: PRK09414 393011000671 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 393011000672 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 393011000673 NAD(P) binding site [chemical binding]; other site 393011000674 pseudogene of ISFtu2 transposase 393011000675 pseudogene of conserved hypothetical protein 393011000676 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 393011000677 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 393011000678 active site 393011000679 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 393011000680 substrate binding site [chemical binding]; other site 393011000681 catalytic residues [active] 393011000682 dimer interface [polypeptide binding]; other site 393011000683 Amino acid permease; Region: AA_permease_2; pfam13520 393011000684 pseudogene of conserved hypothetical protein 393011000685 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 393011000686 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 393011000687 DNA binding site [nucleotide binding] 393011000688 active site 393011000689 Uncharacterized conserved protein [Function unknown]; Region: COG0398 393011000690 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 393011000691 mercuric reductase; Validated; Region: PRK06370 393011000692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393011000693 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 393011000694 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 393011000695 pseudogene of APC family amino acid-polyamine-organocation transporter 393011000696 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 393011000697 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 393011000698 HSP70 interaction site [polypeptide binding]; other site 393011000699 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 393011000700 substrate binding site [polypeptide binding]; other site 393011000701 dimer interface [polypeptide binding]; other site 393011000702 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 393011000703 EamA-like transporter family; Region: EamA; pfam00892 393011000704 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 393011000705 Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; Region: PI3Ka; cl00271 393011000706 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 393011000707 HD domain; Region: HD_4; pfam13328 393011000708 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 393011000709 synthetase active site [active] 393011000710 NTP binding site [chemical binding]; other site 393011000711 metal binding site [ion binding]; metal-binding site 393011000712 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 393011000713 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 393011000714 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 393011000715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393011000716 S-adenosylmethionine binding site [chemical binding]; other site 393011000717 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 393011000718 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 393011000719 active site 393011000720 DNA binding site [nucleotide binding] 393011000721 Int/Topo IB signature motif; other site 393011000722 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 393011000723 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 393011000724 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 393011000725 preprotein translocase subunit SecB; Validated; Region: PRK05751 393011000726 SecA binding site; other site 393011000727 Preprotein binding site; other site 393011000728 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 393011000729 MutS domain I; Region: MutS_I; pfam01624 393011000730 MutS domain III; Region: MutS_III; pfam05192 393011000731 MutS domain V; Region: MutS_V; pfam00488 393011000732 Walker A/P-loop; other site 393011000733 ATP binding site [chemical binding]; other site 393011000734 Q-loop/lid; other site 393011000735 ABC transporter signature motif; other site 393011000736 Walker B; other site 393011000737 D-loop; other site 393011000738 H-loop/switch region; other site 393011000739 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 393011000740 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 393011000741 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 393011000742 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 393011000743 putative active site [active] 393011000744 pseudogene of hypothetical protein 393011000745 pseudogene of ISFtu2 transposase 393011000746 Zeta toxin; Region: Zeta_toxin; pfam06414 393011000747 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 393011000748 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 393011000749 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 393011000750 active site 393011000751 HIGH motif; other site 393011000752 dimer interface [polypeptide binding]; other site 393011000753 KMSKS motif; other site 393011000754 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 393011000755 dephospho-CoA kinase; Region: TIGR00152 393011000756 CoA-binding site [chemical binding]; other site 393011000757 ATP-binding [chemical binding]; other site 393011000758 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 393011000759 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 393011000760 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 393011000761 dimer interface [polypeptide binding]; other site 393011000762 TPP-binding site [chemical binding]; other site 393011000763 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 393011000764 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 393011000765 E3 interaction surface; other site 393011000766 lipoyl attachment site [posttranslational modification]; other site 393011000767 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 393011000768 E3 interaction surface; other site 393011000769 lipoyl attachment site [posttranslational modification]; other site 393011000770 e3 binding domain; Region: E3_binding; pfam02817 393011000771 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 393011000772 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 393011000773 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 393011000774 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393011000775 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 393011000776 pseudogene of ISFtu3 transposase 393011000777 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011000778 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011000779 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011000780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011000781 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 393011000782 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 393011000783 nudix motif; other site 393011000784 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 393011000785 ArsC family; Region: ArsC; pfam03960 393011000786 catalytic residue [active] 393011000787 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 393011000788 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 393011000789 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393011000790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393011000791 homodimer interface [polypeptide binding]; other site 393011000792 catalytic residue [active] 393011000793 pseudogene of AAE family aspartate:alanine exchanger 393011000794 pseudogene of nucleotide-binding DNA uptake protein 393011000795 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 393011000796 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 393011000797 ligand binding site [chemical binding]; other site 393011000798 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 393011000799 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 393011000800 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 393011000801 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 393011000802 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 393011000803 homotrimer interaction site [polypeptide binding]; other site 393011000804 active site 393011000805 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 393011000806 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 393011000807 TolQ protein; Region: tolQ; TIGR02796 393011000808 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 393011000809 TolR protein; Region: tolR; TIGR02801 393011000810 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 393011000811 TolB amino-terminal domain; Region: TolB_N; pfam04052 393011000812 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 393011000813 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 393011000814 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 393011000815 ligand binding site [chemical binding]; other site 393011000816 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 393011000817 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 393011000818 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393011000819 FeS/SAM binding site; other site 393011000820 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 393011000821 Coenzyme A binding pocket [chemical binding]; other site 393011000822 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011000823 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011000824 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011000825 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011000826 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 393011000827 deoxyribodipyrimidine photo-lyase; DNA photolyase 393011000828 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 393011000829 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 393011000830 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 393011000831 bile acid transporter; Region: bass; TIGR00841 393011000832 Sodium Bile acid symporter family; Region: SBF; cl17470 393011000833 pseudogene of conserved hypothetical protein 393011000834 pseudogene of conserved hypothetical protein 393011000835 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 393011000836 pseudogene of arsenite-antimonite efflux family transporter, membrane subunit ArsB 393011000837 Protein of unknown function (DUF423); Region: DUF423; pfam04241 393011000838 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011000839 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011000840 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011000841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011000842 Protein of unknown function, DUF393; Region: DUF393; pfam04134 393011000843 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 393011000844 UbiA prenyltransferase family; Region: UbiA; pfam01040 393011000845 Chorismate lyase; Region: Chor_lyase; cl01230 393011000846 ribonuclease PH; Reviewed; Region: rph; PRK00173 393011000847 Ribonuclease PH; Region: RNase_PH_bact; cd11362 393011000848 hexamer interface [polypeptide binding]; other site 393011000849 active site 393011000850 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 393011000851 heat shock protein HtpX; Provisional; Region: PRK02870 393011000852 LemA family; Region: LemA; cl00742 393011000853 pseudogene of LysR family transcriptional regulator 393011000854 pseudogene of conserved hypothetical protein 393011000855 pseudogene of P-ATPase superfamily P-type ATPase cadmium transporter 393011000856 pseudogene of ISFtu2 transposase 393011000857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393011000858 dimerization interface [polypeptide binding]; other site 393011000859 putative DNA binding site [nucleotide binding]; other site 393011000860 putative Zn2+ binding site [ion binding]; other site 393011000861 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 393011000862 putative active site [active] 393011000863 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 393011000864 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 393011000865 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 393011000866 Colicin V production protein; Region: Colicin_V; pfam02674 393011000867 DNA repair protein RadA; Provisional; Region: PRK11823 393011000868 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 393011000869 Walker A motif/ATP binding site; other site 393011000870 ATP binding site [chemical binding]; other site 393011000871 Walker B motif; other site 393011000872 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 393011000873 PilZ domain; Region: PilZ; pfam07238 393011000874 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 393011000875 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 393011000876 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 393011000877 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 393011000878 Tetramer interface [polypeptide binding]; other site 393011000879 active site 393011000880 FMN-binding site [chemical binding]; other site 393011000881 PQ loop repeat; Region: PQ-loop; pfam04193 393011000882 methionine sulfoxide reductase B; Provisional; Region: PRK00222 393011000883 SelR domain; Region: SelR; pfam01641 393011000884 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 393011000885 E-class dimer interface [polypeptide binding]; other site 393011000886 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 393011000887 P-class dimer interface [polypeptide binding]; other site 393011000888 active site 393011000889 Cu2+ binding site [ion binding]; other site 393011000890 Zn2+ binding site [ion binding]; other site 393011000891 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 393011000892 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 393011000893 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 393011000894 Cupin domain; Region: Cupin_2; cl17218 393011000895 pseudogene of formaldehyde dehydrogenase (glutathione) 393011000896 aspartate aminotransferase; Provisional; Region: PRK07568 393011000897 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393011000898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393011000899 homodimer interface [polypeptide binding]; other site 393011000900 catalytic residue [active] 393011000901 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 393011000902 Cation efflux family; Region: Cation_efflux; pfam01545 393011000903 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 393011000904 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 393011000905 Walker A/P-loop; other site 393011000906 ATP binding site [chemical binding]; other site 393011000907 Q-loop/lid; other site 393011000908 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 393011000909 ABC transporter signature motif; other site 393011000910 Walker B; other site 393011000911 D-loop; other site 393011000912 H-loop/switch region; other site 393011000913 Proteins of 100 residues with WXG; Region: WXG100; cl02005 393011000914 pseudogene of type IV pilus fiber protein 393011000915 pseudogene of type IV pilus fiber protein 393011000916 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 393011000917 Pilin (bacterial filament); Region: Pilin; pfam00114 393011000918 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 393011000919 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 393011000920 active site 393011000921 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 393011000922 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 393011000923 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 393011000924 homodimer interface [polypeptide binding]; other site 393011000925 NADP binding site [chemical binding]; other site 393011000926 substrate binding site [chemical binding]; other site 393011000927 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 393011000928 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 393011000929 dimerization interface [polypeptide binding]; other site 393011000930 putative ATP binding site [chemical binding]; other site 393011000931 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 393011000932 active site 393011000933 ATP binding site [chemical binding]; other site 393011000934 substrate binding site [chemical binding]; other site 393011000935 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 393011000936 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 393011000937 ATP-grasp domain; Region: ATP-grasp_4; cl17255 393011000938 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 393011000939 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 393011000940 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 393011000941 active site 393011000942 substrate binding site [chemical binding]; other site 393011000943 cosubstrate binding site; other site 393011000944 catalytic site [active] 393011000945 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 393011000946 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 393011000947 ATP-grasp domain; Region: ATP-grasp; pfam02222 393011000948 pseudogene of ISFtu2 transposase 393011000949 pseudogene of possible translation protein 393011000950 intracellular septation protein A; Reviewed; Region: PRK00259 393011000951 Glucokinase; Region: Glucokinase; pfam02685 393011000952 glucokinase, proteobacterial type; Region: glk; TIGR00749 393011000953 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 393011000954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393011000955 S-adenosylmethionine binding site [chemical binding]; other site 393011000956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 393011000957 ABC1 family; Region: ABC1; cl17513 393011000958 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 393011000959 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 393011000960 nucleotide binding site/active site [active] 393011000961 HIT family signature motif; other site 393011000962 catalytic residue [active] 393011000963 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 393011000964 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393011000965 active site 393011000966 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 393011000967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 393011000968 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 393011000969 FAD binding domain; Region: FAD_binding_4; pfam01565 393011000970 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 393011000971 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 393011000972 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 393011000973 putative active site [active] 393011000974 GTP-binding protein Der; Reviewed; Region: PRK00093 393011000975 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 393011000976 G1 box; other site 393011000977 GTP/Mg2+ binding site [chemical binding]; other site 393011000978 Switch I region; other site 393011000979 G2 box; other site 393011000980 Switch II region; other site 393011000981 G3 box; other site 393011000982 G4 box; other site 393011000983 G5 box; other site 393011000984 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 393011000985 G1 box; other site 393011000986 GTP/Mg2+ binding site [chemical binding]; other site 393011000987 Switch I region; other site 393011000988 G2 box; other site 393011000989 G3 box; other site 393011000990 Switch II region; other site 393011000991 G4 box; other site 393011000992 G5 box; other site 393011000993 pseudogene of ISFtu2 transposase 393011000994 pseudogene of ISFtu1 transposase 393011000995 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 393011000996 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 393011000997 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 393011000998 active site 393011000999 Zn binding site [ion binding]; other site 393011001000 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 393011001001 pseudogene of conserved hypothetical protein 393011001002 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 393011001003 DNA topoisomerase I; Validated; Region: PRK06599 393011001004 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 393011001005 active site 393011001006 interdomain interaction site; other site 393011001007 putative metal-binding site [ion binding]; other site 393011001008 nucleotide binding site [chemical binding]; other site 393011001009 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 393011001010 domain I; other site 393011001011 DNA binding groove [nucleotide binding] 393011001012 phosphate binding site [ion binding]; other site 393011001013 domain II; other site 393011001014 domain III; other site 393011001015 nucleotide binding site [chemical binding]; other site 393011001016 catalytic site [active] 393011001017 domain IV; other site 393011001018 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 393011001019 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 393011001020 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 393011001021 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 393011001022 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 393011001023 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 393011001024 P-loop; other site 393011001025 Magnesium ion binding site [ion binding]; other site 393011001026 ParB-like nuclease domain; Region: ParB; smart00470 393011001027 KorB domain; Region: KorB; pfam08535 393011001028 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 393011001029 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 393011001030 catalytic triad [active] 393011001031 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 393011001032 active site 393011001033 catalytic triad [active] 393011001034 oxyanion hole [active] 393011001035 pseudogene of conserved hypothetical protein 393011001036 FtsJ-like methyltransferase; Region: FtsJ; cl17430 393011001037 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 393011001038 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 393011001039 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 393011001040 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 393011001041 active site 393011001042 HIGH motif; other site 393011001043 nucleotide binding site [chemical binding]; other site 393011001044 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 393011001045 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 393011001046 active site 393011001047 KMSKS motif; other site 393011001048 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 393011001049 tRNA binding surface [nucleotide binding]; other site 393011001050 anticodon binding site; other site 393011001051 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 393011001052 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 393011001053 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 393011001054 active site 393011001055 Riboflavin kinase; Region: Flavokinase; pfam01687 393011001056 malate dehydrogenase; Provisional; Region: PRK13529 393011001057 Malic enzyme, N-terminal domain; Region: malic; pfam00390 393011001058 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 393011001059 NAD(P) binding pocket [chemical binding]; other site 393011001060 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 393011001061 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 393011001062 pseudogene of ISFtu1 transposase 393011001063 pseudogene of ISFtu2 transposase 393011001064 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 393011001065 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 393011001066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011001067 D-galactonate transporter; Region: 2A0114; TIGR00893 393011001068 putative substrate translocation pore; other site 393011001069 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 393011001070 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 393011001071 active site 393011001072 HIGH motif; other site 393011001073 KMSKS motif; other site 393011001074 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 393011001075 tRNA binding surface [nucleotide binding]; other site 393011001076 anticodon binding site; other site 393011001077 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 393011001078 dimer interface [polypeptide binding]; other site 393011001079 putative tRNA-binding site [nucleotide binding]; other site 393011001080 Predicted flavoprotein [General function prediction only]; Region: COG0431 393011001081 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 393011001082 pseudogene of conserved hypothetical protein 393011001083 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 393011001084 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 393011001085 Peptidase family M50; Region: Peptidase_M50; pfam02163 393011001086 active site 393011001087 putative substrate binding region [chemical binding]; other site 393011001088 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 393011001089 DNA binding residues [nucleotide binding] 393011001090 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 393011001091 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 393011001092 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 393011001093 active site 393011001094 (T/H)XGH motif; other site 393011001095 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 393011001096 nudix motif; other site 393011001097 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 393011001098 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 393011001099 Substrate binding site; other site 393011001100 Mg++ binding site; other site 393011001101 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 393011001102 active site 393011001103 substrate binding site [chemical binding]; other site 393011001104 CoA binding site [chemical binding]; other site 393011001105 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 393011001106 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 393011001107 glutaminase active site [active] 393011001108 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 393011001109 dimer interface [polypeptide binding]; other site 393011001110 active site 393011001111 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 393011001112 dimer interface [polypeptide binding]; other site 393011001113 active site 393011001114 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 393011001115 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 393011001116 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 393011001117 DNA-binding site [nucleotide binding]; DNA binding site 393011001118 RNA-binding motif; other site 393011001119 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 393011001120 metal binding site [ion binding]; metal-binding site 393011001121 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 393011001122 active site 393011001123 PLD-like domain; Region: PLDc_2; pfam13091 393011001124 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 393011001125 putative homodimer interface [polypeptide binding]; other site 393011001126 putative active site [active] 393011001127 catalytic site [active] 393011001128 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 393011001129 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 393011001130 CAP-like domain; other site 393011001131 active site 393011001132 primary dimer interface [polypeptide binding]; other site 393011001133 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 393011001134 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 393011001135 BNR repeat-like domain; Region: BNR_2; pfam13088 393011001136 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 393011001137 Asp-box motif; other site 393011001138 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 393011001139 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 393011001140 N-acetyl-D-glucosamine binding site [chemical binding]; other site 393011001141 catalytic residue [active] 393011001142 pseudogene of ISftu2 transposase 393011001143 Predicted membrane protein [Function unknown]; Region: COG4325 393011001144 pseudogene of conserved hypothetical protein 393011001145 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 393011001146 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 393011001147 putative active site [active] 393011001148 putative PHP Thumb interface [polypeptide binding]; other site 393011001149 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 393011001150 generic binding surface II; other site 393011001151 generic binding surface I; other site 393011001152 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 393011001153 active site 393011001154 catalytic residues [active] 393011001155 metal binding site [ion binding]; metal-binding site 393011001156 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 393011001157 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 393011001158 FtsX-like permease family; Region: FtsX; pfam02687 393011001159 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 393011001160 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393011001161 Walker A/P-loop; other site 393011001162 ATP binding site [chemical binding]; other site 393011001163 Q-loop/lid; other site 393011001164 ABC transporter signature motif; other site 393011001165 Walker B; other site 393011001166 D-loop; other site 393011001167 H-loop/switch region; other site 393011001168 lysine decarboxylase LdcC; Provisional; Region: PRK15399 393011001169 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 393011001170 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 393011001171 homodimer interface [polypeptide binding]; other site 393011001172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393011001173 catalytic residue [active] 393011001174 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 393011001175 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 393011001176 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 393011001177 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 393011001178 lipoyl attachment site [posttranslational modification]; other site 393011001179 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 393011001180 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 393011001181 tetramer interface [polypeptide binding]; other site 393011001182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393011001183 catalytic residue [active] 393011001184 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 393011001185 tetramer interface [polypeptide binding]; other site 393011001186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393011001187 catalytic residue [active] 393011001188 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 393011001189 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 393011001190 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 393011001191 shikimate binding site; other site 393011001192 NAD(P) binding site [chemical binding]; other site 393011001193 pullulanase, type I; Region: pulA_typeI; TIGR02104 393011001194 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 393011001195 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 393011001196 Ca binding site [ion binding]; other site 393011001197 active site 393011001198 catalytic site [active] 393011001199 glycogen branching enzyme; Provisional; Region: PRK12313 393011001200 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 393011001201 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 393011001202 active site 393011001203 catalytic site [active] 393011001204 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 393011001205 phosphoglucomutase; Region: PLN02307 393011001206 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 393011001207 substrate binding site [chemical binding]; other site 393011001208 dimer interface [polypeptide binding]; other site 393011001209 active site 393011001210 metal binding site [ion binding]; metal-binding site 393011001211 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 393011001212 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 393011001213 ligand binding site; other site 393011001214 oligomer interface; other site 393011001215 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 393011001216 dimer interface [polypeptide binding]; other site 393011001217 N-terminal domain interface [polypeptide binding]; other site 393011001218 sulfate 1 binding site; other site 393011001219 glycogen synthase; Provisional; Region: glgA; PRK00654 393011001220 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 393011001221 ADP-binding pocket [chemical binding]; other site 393011001222 homodimer interface [polypeptide binding]; other site 393011001223 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 393011001224 homodimer interface [polypeptide binding]; other site 393011001225 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 393011001226 active site pocket [active] 393011001227 4-alpha-glucanotransferase; Provisional; Region: PRK14508 393011001228 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 393011001229 dimer interface [polypeptide binding]; other site 393011001230 motif 1; other site 393011001231 active site 393011001232 motif 2; other site 393011001233 motif 3; other site 393011001234 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 393011001235 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 393011001236 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393011001237 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 393011001238 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 393011001239 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 393011001240 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 393011001241 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393011001242 aspartate-semialdehyde dehydrogenase; ASA dehydrogenase 393011001243 aspartate kinase; aspartokinase 393011001244 fragment of homoserine kinase 393011001245 threonine synthase; Validated; Region: PRK09225 393011001246 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 393011001247 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393011001248 catalytic residue [active] 393011001249 beta-galactosidase; exo-(1->4)-beta-D-galactanase 393011001250 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 393011001251 spermidine synthase; Provisional; Region: PRK00811 393011001252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393011001253 pseudogene of arginine decarboxylase 393011001254 pseudogene of conserved hypothetical protein 393011001255 pseudogene of ISFtu1 transposase 393011001256 pseudogene of carbon-nitrogen family hydrolase 393011001257 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 393011001258 putative active site [active] 393011001259 putative metal binding site [ion binding]; other site 393011001260 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393011001261 active site 393011001262 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 393011001263 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 393011001264 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393011001265 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 393011001266 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 393011001267 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 393011001268 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011001269 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011001270 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011001271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011001272 BolA-like protein; Region: BolA; cl00386 393011001273 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 393011001274 anti sigma factor interaction site; other site 393011001275 regulatory phosphorylation site [posttranslational modification]; other site 393011001276 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 393011001277 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 393011001278 mce related protein; Region: MCE; pfam02470 393011001279 Permease; Region: Permease; pfam02405 393011001280 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 393011001281 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 393011001282 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 393011001283 Walker A/P-loop; other site 393011001284 ATP binding site [chemical binding]; other site 393011001285 Q-loop/lid; other site 393011001286 ABC transporter signature motif; other site 393011001287 Walker B; other site 393011001288 D-loop; other site 393011001289 H-loop/switch region; other site 393011001290 cell division topological specificity factor MinE; Provisional; Region: PRK13990 393011001291 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 393011001292 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 393011001293 Switch I; other site 393011001294 Switch II; other site 393011001295 septum formation inhibitor; Reviewed; Region: minC; PRK04804 393011001296 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 393011001297 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 393011001298 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 393011001299 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 393011001300 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 393011001301 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 393011001302 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 393011001303 ssDNA binding site; other site 393011001304 generic binding surface II; other site 393011001305 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393011001306 ATP binding site [chemical binding]; other site 393011001307 putative Mg++ binding site [ion binding]; other site 393011001308 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393011001309 nucleotide binding region [chemical binding]; other site 393011001310 ATP-binding site [chemical binding]; other site 393011001311 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 393011001312 Fumarase C-terminus; Region: Fumerase_C; pfam05683 393011001313 fragment of conserved hypothetical protein 393011001314 pseudogene of ISFtu1transposase 393011001315 pseudogene of type III restriction-modification system protein fragment 393011001316 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 393011001317 GIY-YIG motif/motif A; other site 393011001318 putative active site [active] 393011001319 putative metal binding site [ion binding]; other site 393011001320 pseudogene of conserved hypothetical protein 393011001321 Restriction endonuclease [Defense mechanisms]; Region: COG3587 393011001322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393011001323 ATP binding site [chemical binding]; other site 393011001324 putative Mg++ binding site [ion binding]; other site 393011001325 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 393011001326 ligand binding site [chemical binding]; other site 393011001327 active site 393011001328 UGI interface [polypeptide binding]; other site 393011001329 catalytic site [active] 393011001330 pseudogene of conserved hypothetical protein 393011001331 DNA gyrase subunit A; Validated; Region: PRK05560 393011001332 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 393011001333 CAP-like domain; other site 393011001334 active site 393011001335 primary dimer interface [polypeptide binding]; other site 393011001336 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393011001337 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393011001338 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393011001339 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393011001340 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393011001341 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393011001342 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 393011001343 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 393011001344 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 393011001345 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 393011001346 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 393011001347 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 393011001348 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 393011001349 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 393011001350 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 393011001351 Surface antigen; Region: Bac_surface_Ag; pfam01103 393011001352 periplasmic chaperone; Provisional; Region: PRK10780 393011001353 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 393011001354 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 393011001355 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 393011001356 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 393011001357 trimer interface [polypeptide binding]; other site 393011001358 active site 393011001359 UDP-GlcNAc binding site [chemical binding]; other site 393011001360 lipid binding site [chemical binding]; lipid-binding site 393011001361 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 393011001362 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 393011001363 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 393011001364 active site 393011001365 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 393011001366 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 393011001367 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 393011001368 active site 393011001369 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 393011001370 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 393011001371 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 393011001372 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 393011001373 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 393011001374 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 393011001375 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 393011001376 substrate binding pocket [chemical binding]; other site 393011001377 chain length determination region; other site 393011001378 substrate-Mg2+ binding site; other site 393011001379 catalytic residues [active] 393011001380 aspartate-rich region 1; other site 393011001381 active site lid residues [active] 393011001382 aspartate-rich region 2; other site 393011001383 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 393011001384 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 393011001385 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 393011001386 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 393011001387 active site 393011001388 dimerization interface [polypeptide binding]; other site 393011001389 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 393011001390 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 393011001391 pseudogene of conserved hypothetical protein 393011001392 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393011001393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393011001394 active site 393011001395 phosphorylation site [posttranslational modification] 393011001396 intermolecular recognition site; other site 393011001397 dimerization interface [polypeptide binding]; other site 393011001398 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393011001399 DNA binding site [nucleotide binding] 393011001400 signal peptidase I; Provisional; Region: PRK10861 393011001401 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 393011001402 Catalytic site [active] 393011001403 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 393011001404 ribonuclease III; Reviewed; Region: rnc; PRK00102 393011001405 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 393011001406 dimerization interface [polypeptide binding]; other site 393011001407 active site 393011001408 metal binding site [ion binding]; metal-binding site 393011001409 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 393011001410 dsRNA binding site [nucleotide binding]; other site 393011001411 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 393011001412 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 393011001413 RNA binding site [nucleotide binding]; other site 393011001414 active site 393011001415 ribonuclease R; Region: RNase_R; TIGR02063 393011001416 RNB domain; Region: RNB; pfam00773 393011001417 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 393011001418 RNA binding site [nucleotide binding]; other site 393011001419 stearoyl-CoA 9-desaturase; acyl-CoA desaturase 393011001420 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 393011001421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 393011001422 NAD(P) binding site [chemical binding]; other site 393011001423 active site 393011001424 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 393011001425 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 393011001426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393011001427 S-adenosylmethionine binding site [chemical binding]; other site 393011001428 Protein of unknown function (DUF1365); Region: DUF1365; cl17838 393011001429 Protein of unknown function (DUF1365); Region: DUF1365; cl17838 393011001430 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 393011001431 pseudogene of possible sensor kinase 393011001432 pseudogene of two component response regulator 393011001433 pseudogene of ISFtu2 transposase 393011001434 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 393011001435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 393011001436 pseudogene of ISFtu2 transposase 393011001437 pseudogene of conserved hypothetical protein 393011001438 pseudogene of ornithine cyclodeaminase 393011001439 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 393011001440 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 393011001441 active site 393011001442 Protein of unknown function (DUF465); Region: DUF465; pfam04325 393011001443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011001444 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 393011001445 putative substrate translocation pore; other site 393011001446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 393011001447 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 393011001448 CoenzymeA binding site [chemical binding]; other site 393011001449 subunit interaction site [polypeptide binding]; other site 393011001450 PHB binding site; other site 393011001451 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 393011001452 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 393011001453 dimer interface [polypeptide binding]; other site 393011001454 active site 393011001455 Acyl CoA binding protein; Region: ACBP; pfam00887 393011001456 acyl-CoA binding pocket [chemical binding]; other site 393011001457 CoA binding site [chemical binding]; other site 393011001458 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 393011001459 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 393011001460 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 393011001461 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 393011001462 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 393011001463 substrate binding site [chemical binding]; other site 393011001464 oxyanion hole (OAH) forming residues; other site 393011001465 trimer interface [polypeptide binding]; other site 393011001466 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 393011001467 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 393011001468 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 393011001469 active site 393011001470 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 393011001471 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 393011001472 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 393011001473 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 393011001474 acyl-activating enzyme (AAE) consensus motif; other site 393011001475 AMP binding site [chemical binding]; other site 393011001476 active site 393011001477 CoA binding site [chemical binding]; other site 393011001478 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 393011001479 ArsC family; Region: ArsC; pfam03960 393011001480 catalytic residues [active] 393011001481 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 393011001482 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 393011001483 DEAD-like helicases superfamily; Region: DEXDc; smart00487 393011001484 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393011001485 ATP binding site [chemical binding]; other site 393011001486 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 393011001487 putative Mg++ binding site [ion binding]; other site 393011001488 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393011001489 nucleotide binding region [chemical binding]; other site 393011001490 ATP-binding site [chemical binding]; other site 393011001491 Helicase associated domain (HA2); Region: HA2; pfam04408 393011001492 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 393011001493 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 393011001494 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 393011001495 pseudogene of ISFtu2 transposase 393011001496 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 393011001497 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 393011001498 NAD(P) binding site [chemical binding]; other site 393011001499 homodimer interface [polypeptide binding]; other site 393011001500 substrate binding site [chemical binding]; other site 393011001501 active site 393011001502 Bacterial sugar transferase; Region: Bac_transf; pfam02397 393011001503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 393011001504 NADH(P)-binding; Region: NAD_binding_10; pfam13460 393011001505 NAD(P) binding site [chemical binding]; other site 393011001506 active site 393011001507 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 393011001508 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 393011001509 putative ADP-binding pocket [chemical binding]; other site 393011001510 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 393011001511 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 393011001512 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 393011001513 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 393011001514 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 393011001515 NAD binding site [chemical binding]; other site 393011001516 substrate binding site [chemical binding]; other site 393011001517 homodimer interface [polypeptide binding]; other site 393011001518 active site 393011001519 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 393011001520 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 393011001521 putative ADP-binding pocket [chemical binding]; other site 393011001522 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 393011001523 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 393011001524 active site 393011001525 dimer interface [polypeptide binding]; other site 393011001526 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 393011001527 Ligand Binding Site [chemical binding]; other site 393011001528 Molecular Tunnel; other site 393011001529 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 393011001530 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 393011001531 inhibitor-cofactor binding pocket; inhibition site 393011001532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393011001533 catalytic residue [active] 393011001534 hypothetical protein; Provisional; Region: PRK07579 393011001535 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 393011001536 active site 393011001537 cosubstrate binding site; other site 393011001538 substrate binding site [chemical binding]; other site 393011001539 catalytic site [active] 393011001540 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 393011001541 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 393011001542 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 393011001543 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 393011001544 active site 393011001545 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 393011001546 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 393011001547 substrate binding site; other site 393011001548 tetramer interface; other site 393011001549 pseudogene of possible endonuclease 393011001550 pseudogene of dTDP-glucose 4,6-dehydratase 393011001551 pseudogene of ISFtu1 transposase 393011001552 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 393011001553 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 393011001554 Substrate binding site; other site 393011001555 Cupin domain; Region: Cupin_2; cl17218 393011001556 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 393011001557 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 393011001558 active site 393011001559 substrate binding site [chemical binding]; other site 393011001560 metal binding site [ion binding]; metal-binding site 393011001561 transcription termination factor Rho; Provisional; Region: rho; PRK09376 393011001562 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 393011001563 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 393011001564 RNA binding site [nucleotide binding]; other site 393011001565 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 393011001566 multimer interface [polypeptide binding]; other site 393011001567 Walker A motif; other site 393011001568 ATP binding site [chemical binding]; other site 393011001569 Walker B motif; other site 393011001570 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 393011001571 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 393011001572 catalytic residues [active] 393011001573 exopolyphosphatase; Region: exo_poly_only; TIGR03706 393011001574 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 393011001575 pseudogene of ISFtu2 transposase 393011001576 recombination factor protein RarA; Provisional; Region: PRK14700 393011001577 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 393011001578 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 393011001579 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 393011001580 dimer interface [polypeptide binding]; other site 393011001581 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 393011001582 Ferritin-like domain; Region: Ferritin; pfam00210 393011001583 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 393011001584 dinuclear metal binding motif [ion binding]; other site 393011001585 pseudogene of MFS family major facilitator transporter; pseudogene of probable multidrug resistance transporter 393011001586 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 393011001587 active site 393011001588 Cupin domain; Region: Cupin_2; cl17218 393011001589 hypothetical protein; Provisional; Region: PRK10621 393011001590 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 393011001591 pseudogene of ISFtu2 transposase 393011001592 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393011001593 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 393011001594 Walker A/P-loop; other site 393011001595 ATP binding site [chemical binding]; other site 393011001596 Q-loop/lid; other site 393011001597 ABC transporter signature motif; other site 393011001598 Walker B; other site 393011001599 D-loop; other site 393011001600 H-loop/switch region; other site 393011001601 inner membrane transport permease; Provisional; Region: PRK15066 393011001602 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 393011001603 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 393011001604 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 393011001605 Ligand binding site; other site 393011001606 Putative Catalytic site; other site 393011001607 DXD motif; other site 393011001608 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 393011001609 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 393011001610 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 393011001611 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 393011001612 pseudogene of acetyltransferase 393011001613 pseudogene of ISFtu1 transposase 393011001614 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393011001615 putative DNA binding site [nucleotide binding]; other site 393011001616 putative Zn2+ binding site [ion binding]; other site 393011001617 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 393011001618 active site residue [active] 393011001619 NADH dehydrogenase; beta-NADH dehydrogenase dinucleotide 393011001620 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 393011001621 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 393011001622 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 393011001623 hypothetical protein; Provisional; Region: PRK05170 393011001624 pseudogene of conserved hypothetical protein 393011001625 transcription antitermination factor NusB; Region: nusB; TIGR01951 393011001626 putative RNA binding site [nucleotide binding]; other site 393011001627 C-N hydrolase family amidase; Provisional; Region: PRK10438 393011001628 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 393011001629 putative active site [active] 393011001630 catalytic triad [active] 393011001631 dimer interface [polypeptide binding]; other site 393011001632 multimer interface [polypeptide binding]; other site 393011001633 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 393011001634 pseudogene of aminotransferase 393011001635 prolyl-tRNA synthetase; Provisional; Region: PRK09194 393011001636 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 393011001637 dimer interface [polypeptide binding]; other site 393011001638 motif 1; other site 393011001639 active site 393011001640 motif 2; other site 393011001641 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 393011001642 putative deacylase active site [active] 393011001643 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 393011001644 active site 393011001645 motif 3; other site 393011001646 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 393011001647 anticodon binding site; other site 393011001648 pseudogene of ISFtu5 transposase 393011001649 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 393011001650 nucleic acid binding site [nucleotide binding]; other site 393011001651 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 393011001652 Fe-S metabolism associated domain; Region: SufE; cl00951 393011001653 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 393011001654 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 393011001655 active site 393011001656 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 393011001657 Sporulation related domain; Region: SPOR; pfam05036 393011001658 FeoA domain; Region: FeoA; cl00838 393011001659 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 393011001660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393011001661 non-specific DNA binding site [nucleotide binding]; other site 393011001662 salt bridge; other site 393011001663 sequence-specific DNA binding site [nucleotide binding]; other site 393011001664 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 393011001665 Catalytic site [active] 393011001666 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 393011001667 EamA-like transporter family; Region: EamA; pfam00892 393011001668 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 393011001669 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 393011001670 active site 393011001671 FMN binding site [chemical binding]; other site 393011001672 substrate binding site [chemical binding]; other site 393011001673 3Fe-4S cluster binding site [ion binding]; other site 393011001674 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 393011001675 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 393011001676 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 393011001677 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 393011001678 Divergent AAA domain; Region: AAA_4; pfam04326 393011001679 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 393011001680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393011001681 putative DNA binding site [nucleotide binding]; other site 393011001682 putative Zn2+ binding site [ion binding]; other site 393011001683 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 393011001684 Family description; Region: UvrD_C_2; pfam13538 393011001685 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 393011001686 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 393011001687 AAA domain; Region: AAA_30; pfam13604 393011001688 Family description; Region: UvrD_C_2; pfam13538 393011001689 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393011001690 nucleotide binding site [chemical binding]; other site 393011001691 Type III pantothenate kinase; Region: Pan_kinase; cl17198 393011001692 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 393011001693 tetramerization interface [polypeptide binding]; other site 393011001694 active site 393011001695 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 393011001696 pantoate--beta-alanine ligase; Region: panC; TIGR00018 393011001697 active site 393011001698 nucleotide binding site [chemical binding]; other site 393011001699 HIGH motif; other site 393011001700 KMSKS motif; other site 393011001701 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 393011001702 active site 393011001703 oligomerization interface [polypeptide binding]; other site 393011001704 metal binding site [ion binding]; metal-binding site 393011001705 Uncharacterized conserved protein [Function unknown]; Region: COG5495 393011001706 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 393011001707 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 393011001708 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 393011001709 nucleotide binding pocket [chemical binding]; other site 393011001710 K-X-D-G motif; other site 393011001711 catalytic site [active] 393011001712 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 393011001713 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 393011001714 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 393011001715 Dimer interface [polypeptide binding]; other site 393011001716 BRCT sequence motif; other site 393011001717 pseudogene of ISFtu1 transposase 393011001718 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 393011001719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393011001720 dimer interface [polypeptide binding]; other site 393011001721 conserved gate region; other site 393011001722 putative PBP binding loops; other site 393011001723 ABC-ATPase subunit interface; other site 393011001724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393011001725 dimer interface [polypeptide binding]; other site 393011001726 conserved gate region; other site 393011001727 putative PBP binding loops; other site 393011001728 ABC-ATPase subunit interface; other site 393011001729 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 393011001730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393011001731 Walker A/P-loop; other site 393011001732 ATP binding site [chemical binding]; other site 393011001733 Q-loop/lid; other site 393011001734 ABC transporter signature motif; other site 393011001735 Walker B; other site 393011001736 D-loop; other site 393011001737 H-loop/switch region; other site 393011001738 TOBE domain; Region: TOBE_2; pfam08402 393011001739 pseudogene of ISFtu1 transposase 393011001740 pseudogene of possible flavodoxin 393011001741 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 393011001742 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 393011001743 homodimer interface [polypeptide binding]; other site 393011001744 NAD binding pocket [chemical binding]; other site 393011001745 ATP binding pocket [chemical binding]; other site 393011001746 Mg binding site [ion binding]; other site 393011001747 active-site loop [active] 393011001748 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 393011001749 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 393011001750 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 393011001751 HlyD family secretion protein; Region: HlyD_3; pfam13437 393011001752 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 393011001753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011001754 putative substrate translocation pore; other site 393011001755 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 393011001756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393011001757 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 393011001758 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 393011001759 acyl-activating enzyme (AAE) consensus motif; other site 393011001760 putative AMP binding site [chemical binding]; other site 393011001761 putative active site [active] 393011001762 putative CoA binding site [chemical binding]; other site 393011001763 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 393011001764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011001765 putative substrate translocation pore; other site 393011001766 POT family; Region: PTR2; cl17359 393011001767 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 393011001768 RNA methyltransferase, RsmE family; Region: TIGR00046 393011001769 Protein of unknown function (DUF445); Region: DUF445; pfam04286 393011001770 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 393011001771 mce related protein; Region: MCE; pfam02470 393011001772 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 393011001773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393011001774 Walker A/P-loop; other site 393011001775 ATP binding site [chemical binding]; other site 393011001776 Q-loop/lid; other site 393011001777 ABC transporter signature motif; other site 393011001778 Walker B; other site 393011001779 D-loop; other site 393011001780 H-loop/switch region; other site 393011001781 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 393011001782 Permease; Region: Permease; pfam02405 393011001783 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 393011001784 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 393011001785 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393011001786 RNA binding surface [nucleotide binding]; other site 393011001787 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 393011001788 active site 393011001789 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 393011001790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 393011001791 TPR motif; other site 393011001792 binding surface 393011001793 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 393011001794 FAD binding domain; Region: FAD_binding_4; pfam01565 393011001795 Berberine and berberine like; Region: BBE; pfam08031 393011001796 pseudogene of conserved hypothetical protein 393011001797 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 393011001798 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 393011001799 dimer interface [polypeptide binding]; other site 393011001800 active site 393011001801 glycine-pyridoxal phosphate binding site [chemical binding]; other site 393011001802 folate binding site [chemical binding]; other site 393011001803 hypothetical protein; Provisional; Region: PRK05255 393011001804 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 393011001805 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 393011001806 Ligand binding site; other site 393011001807 metal-binding site 393011001808 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 393011001809 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 393011001810 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 393011001811 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 393011001812 active site 393011001813 pseudogene of POT family proton (H+)-dependent oligopeptide transporter 393011001814 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 393011001815 Ligand Binding Site [chemical binding]; other site 393011001816 TilS substrate C-terminal domain; Region: TilS_C; smart00977 393011001817 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 393011001818 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 393011001819 ligand binding site [chemical binding]; other site 393011001820 NAD binding site [chemical binding]; other site 393011001821 tetramer interface [polypeptide binding]; other site 393011001822 catalytic site [active] 393011001823 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 393011001824 L-serine binding site [chemical binding]; other site 393011001825 ACT domain interface; other site 393011001826 thymidylate synthase; Reviewed; Region: thyA; PRK01827 393011001827 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 393011001828 dimerization interface [polypeptide binding]; other site 393011001829 active site 393011001830 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 393011001831 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 393011001832 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 393011001833 homodimer interface [polypeptide binding]; other site 393011001834 oligonucleotide binding site [chemical binding]; other site 393011001835 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 393011001836 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 393011001837 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393011001838 catalytic residue [active] 393011001839 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 393011001840 Recombination protein O N terminal; Region: RecO_N; pfam11967 393011001841 Recombination protein O C terminal; Region: RecO_C; pfam02565 393011001842 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 393011001843 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 393011001844 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 393011001845 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 393011001846 BolA-like protein; Region: BolA; cl00386 393011001847 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 393011001848 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 393011001849 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 393011001850 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 393011001851 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 393011001852 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 393011001853 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 393011001854 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 393011001855 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 393011001856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393011001857 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 393011001858 active site 393011001859 motif I; other site 393011001860 motif II; other site 393011001861 Soluble P-type ATPase [General function prediction only]; Region: COG4087 393011001862 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 393011001863 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393011001864 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 393011001865 dimer interface [polypeptide binding]; other site 393011001866 active site 393011001867 metal binding site [ion binding]; metal-binding site 393011001868 glutathione binding site [chemical binding]; other site 393011001869 pseudogene of conserved hypothetical protein 393011001870 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011001871 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011001872 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011001873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011001874 pseudogene of M13 family peptidase 393011001875 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 393011001876 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393011001877 active site 393011001878 dimer interface [polypeptide binding]; other site 393011001879 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 393011001880 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 393011001881 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 393011001882 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 393011001883 pseudogene of LysR family transcriptional regulator 393011001884 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 393011001885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 393011001886 NAD(P) binding site [chemical binding]; other site 393011001887 active site 393011001888 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 393011001889 active site 393011001890 catalytic site [active] 393011001891 substrate binding site [chemical binding]; other site 393011001892 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 393011001893 excinuclease ABC subunit B; Provisional; Region: PRK05298 393011001894 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393011001895 ATP binding site [chemical binding]; other site 393011001896 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393011001897 nucleotide binding region [chemical binding]; other site 393011001898 ATP-binding site [chemical binding]; other site 393011001899 Ultra-violet resistance protein B; Region: UvrB; pfam12344 393011001900 UvrB/uvrC motif; Region: UVR; pfam02151 393011001901 Nuclease-related domain; Region: NERD; pfam08378 393011001902 glutamate racemase; Provisional; Region: PRK00865 393011001903 metabolite-proton symporter; Region: 2A0106; TIGR00883 393011001904 pseudogene of ISFtu2 transposase 393011001905 pseudogene of conserved hypothetical protein 393011001906 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 393011001907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 393011001908 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 393011001909 putative dimer interface [polypeptide binding]; other site 393011001910 putative active site [active] 393011001911 Glutamine amidotransferases class-II; Region: GATase_4; pfam13230 393011001912 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 393011001913 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 393011001914 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 393011001915 aminoacylase; acylase I 393011001916 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 393011001917 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 393011001918 generic binding surface II; other site 393011001919 generic binding surface I; other site 393011001920 pseudogene of MFS family major facilitator transporter 393011001921 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 393011001922 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 393011001923 Ligand Binding Site [chemical binding]; other site 393011001924 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 393011001925 SmpB-tmRNA interface; other site 393011001926 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 393011001927 putative coenzyme Q binding site [chemical binding]; other site 393011001928 hypothetical protein; Validated; Region: PRK01777 393011001929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 393011001930 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 393011001931 VacJ like lipoprotein; Region: VacJ; cl01073 393011001932 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 393011001933 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 393011001934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393011001935 S-adenosylmethionine binding site [chemical binding]; other site 393011001936 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 393011001937 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 393011001938 G1 box; other site 393011001939 putative GEF interaction site [polypeptide binding]; other site 393011001940 GTP/Mg2+ binding site [chemical binding]; other site 393011001941 Switch I region; other site 393011001942 G2 box; other site 393011001943 G3 box; other site 393011001944 Switch II region; other site 393011001945 G4 box; other site 393011001946 G5 box; other site 393011001947 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 393011001948 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 393011001949 type I site-specific deoxyribonuclease; type I restriction enzyme 393011001950 type I site-specific deoxyribonuclease; type I restriction enzyme 393011001951 pseudogene of possible cold shock protein 393011001952 type I site-specific deoxyribonuclease; type I restriction enzyme 393011001953 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011001954 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011001955 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011001956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011001957 Sel1-like repeats; Region: SEL1; smart00671 393011001958 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 393011001959 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 393011001960 GTP/Mg2+ binding site [chemical binding]; other site 393011001961 G4 box; other site 393011001962 G5 box; other site 393011001963 G1 box; other site 393011001964 Switch I region; other site 393011001965 G2 box; other site 393011001966 G3 box; other site 393011001967 Switch II region; other site 393011001968 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 393011001969 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 393011001970 active site 393011001971 dimer interface [polypeptide binding]; other site 393011001972 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 393011001973 Glycoprotease family; Region: Peptidase_M22; pfam00814 393011001974 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 393011001975 putative active site [active] 393011001976 putative dimer interface [polypeptide binding]; other site 393011001977 aspartate aminotransferase; Provisional; Region: PRK05764 393011001978 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393011001979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393011001980 homodimer interface [polypeptide binding]; other site 393011001981 catalytic residue [active] 393011001982 GTPase Era; Reviewed; Region: era; PRK00089 393011001983 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 393011001984 G1 box; other site 393011001985 GTP/Mg2+ binding site [chemical binding]; other site 393011001986 Switch I region; other site 393011001987 G2 box; other site 393011001988 Switch II region; other site 393011001989 G3 box; other site 393011001990 G4 box; other site 393011001991 G5 box; other site 393011001992 pseudogene of Fe-S oxidoreductase 393011001993 adenylate kinase; Reviewed; Region: adk; PRK00279 393011001994 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 393011001995 AMP-binding site [chemical binding]; other site 393011001996 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 393011001997 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 393011001998 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 393011001999 Pilus assembly protein, PilO; Region: PilO; cl01234 393011002000 Pilus assembly protein, PilP; Region: PilP; pfam04351 393011002001 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 393011002002 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 393011002003 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 393011002004 shikimate kinase; Reviewed; Region: aroK; PRK00131 393011002005 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 393011002006 ADP binding site [chemical binding]; other site 393011002007 magnesium binding site [ion binding]; other site 393011002008 putative shikimate binding site; other site 393011002009 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 393011002010 active site 393011002011 dimer interface [polypeptide binding]; other site 393011002012 metal binding site [ion binding]; metal-binding site 393011002013 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 393011002014 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 393011002015 Proline dehydrogenase; Region: Pro_dh; pfam01619 393011002016 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 393011002017 Glutamate binding site [chemical binding]; other site 393011002018 NAD binding site [chemical binding]; other site 393011002019 catalytic residues [active] 393011002020 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 393011002021 NAD(P) binding site [chemical binding]; other site 393011002022 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 393011002023 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 393011002024 benzoate transport; Region: 2A0115; TIGR00895 393011002025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011002026 putative substrate translocation pore; other site 393011002027 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 393011002028 Flavoprotein; Region: Flavoprotein; pfam02441 393011002029 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 393011002030 aldose 1-epimerase; aldose mutarotase 393011002031 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 393011002032 pseudogene of short-chain dehydrogenase/reductase (SDR) family protein 393011002033 PRC-barrel domain; Region: PRC; pfam05239 393011002034 pseudogene of conserved hypothetical protein 393011002035 deoxyribodipyrimidine photo-lyase; DNA photolyase 393011002036 pseudogene of ISFtu2 transposase 393011002037 ferrochelatase; Reviewed; Region: hemH; PRK00035 393011002038 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 393011002039 C-terminal domain interface [polypeptide binding]; other site 393011002040 active site 393011002041 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 393011002042 active site 393011002043 N-terminal domain interface [polypeptide binding]; other site 393011002044 pseudogene of ATPase 393011002045 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 393011002046 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 393011002047 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 393011002048 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 393011002049 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 393011002050 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 393011002051 Walker A motif; other site 393011002052 ATP binding site [chemical binding]; other site 393011002053 Walker B motif; other site 393011002054 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 393011002055 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 393011002056 active site 393011002057 catalytic site [active] 393011002058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 393011002059 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 393011002060 putative MPT binding site; other site 393011002061 cyanophycin synthetase; Provisional; Region: PRK14016 393011002062 ATP-grasp domain; Region: ATP-grasp_4; cl17255 393011002063 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393011002064 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 393011002065 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393011002066 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 393011002067 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 393011002068 homotrimer interaction site [polypeptide binding]; other site 393011002069 zinc binding site [ion binding]; other site 393011002070 CDP-binding sites; other site 393011002071 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 393011002072 active site residue [active] 393011002073 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 393011002074 active site residue [active] 393011002075 pseudogene of ABC superfamily ATP binding cassette transporter, membrane/binding protein 393011002076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393011002077 dimer interface [polypeptide binding]; other site 393011002078 conserved gate region; other site 393011002079 putative PBP binding loops; other site 393011002080 ABC-ATPase subunit interface; other site 393011002081 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 393011002082 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 393011002083 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 393011002084 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 393011002085 Walker A/P-loop; other site 393011002086 ATP binding site [chemical binding]; other site 393011002087 Q-loop/lid; other site 393011002088 ABC transporter signature motif; other site 393011002089 Walker B; other site 393011002090 D-loop; other site 393011002091 H-loop/switch region; other site 393011002092 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 393011002093 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 393011002094 pseudogene of conserved hypothetical protein 393011002095 pseudogene of ISFtu3 transposase 393011002096 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 393011002097 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 393011002098 pseudogene of LysR family transcriptional regulator 393011002099 pseudogene of conserved hypothetical protein 393011002100 Isochorismatase family; Region: Isochorismatase; pfam00857 393011002101 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 393011002102 catalytic triad [active] 393011002103 conserved cis-peptide bond; other site 393011002104 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 393011002105 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 393011002106 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 393011002107 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 393011002108 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 393011002109 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 393011002110 Protein export membrane protein; Region: SecD_SecF; pfam02355 393011002111 Src Homology 3 domain superfamily; Region: SH3; cl17036 393011002112 peptide ligand binding site [polypeptide binding]; other site 393011002113 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 393011002114 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 393011002115 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 393011002116 DNA binding residues [nucleotide binding] 393011002117 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 393011002118 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 393011002119 hinge; other site 393011002120 active site 393011002121 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 393011002122 RNA/DNA hybrid binding site [nucleotide binding]; other site 393011002123 active site 393011002124 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 393011002125 active site 393011002126 homodimer interface [polypeptide binding]; other site 393011002127 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 393011002128 active site clefts [active] 393011002129 zinc binding site [ion binding]; other site 393011002130 dimer interface [polypeptide binding]; other site 393011002131 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 393011002132 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 393011002133 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393011002134 catalytic residue [active] 393011002135 Rubredoxin [Energy production and conversion]; Region: COG1773 393011002136 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 393011002137 iron binding site [ion binding]; other site 393011002138 pseudogene of ISFtu2 transposase 393011002139 pseudogene of conserved hypothetical protein 393011002140 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 393011002141 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 393011002142 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 393011002143 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 393011002144 dimer interface [polypeptide binding]; other site 393011002145 active site 393011002146 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 393011002147 dimer interface [polypeptide binding]; other site 393011002148 active site 393011002149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011002150 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 393011002151 putative substrate translocation pore; other site 393011002152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011002153 pseudogene of ISFtu6 transposase 393011002154 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 393011002155 pseudogene of ISFtu2 transposase 393011002156 beta-N-acetylhexosaminidase; beta-hexosaminidase 393011002157 pseudogene of CPA1 family monovalent cation:proton (H+) antiporter-1 393011002158 pseudogene of conserved hypothetical protein 393011002159 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 393011002160 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 393011002161 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 393011002162 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 393011002163 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 393011002164 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 393011002165 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 393011002166 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 393011002167 active site 393011002168 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 393011002169 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 393011002170 active site 393011002171 substrate binding site [chemical binding]; other site 393011002172 Mg2+ binding site [ion binding]; other site 393011002173 beta-lactamase TEM; Provisional; Region: PRK15442 393011002174 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 393011002175 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 393011002176 pseudogene of conserved hypothetical protein 393011002177 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 393011002178 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 393011002179 putative active site [active] 393011002180 catalytic triad [active] 393011002181 putative dimer interface [polypeptide binding]; other site 393011002182 FOG: CBS domain [General function prediction only]; Region: COG0517 393011002183 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 393011002184 Transporter associated domain; Region: CorC_HlyC; smart01091 393011002185 metal-binding heat shock protein; Provisional; Region: PRK00016 393011002186 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 393011002187 PhoH-like protein; Region: PhoH; pfam02562 393011002188 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 393011002189 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 393011002190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393011002191 FeS/SAM binding site; other site 393011002192 TRAM domain; Region: TRAM; pfam01938 393011002193 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 393011002194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 393011002195 pseudogene of conserved hypothetical protein 393011002196 thymidine kinase; Provisional; Region: PRK04296 393011002197 trigger factor; Provisional; Region: tig; PRK01490 393011002198 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 393011002199 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 393011002200 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 393011002201 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 393011002202 oligomer interface [polypeptide binding]; other site 393011002203 active site residues [active] 393011002204 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 393011002205 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 393011002206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393011002207 Walker A motif; other site 393011002208 ATP binding site [chemical binding]; other site 393011002209 Walker B motif; other site 393011002210 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 393011002211 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 393011002212 Found in ATP-dependent protease La (LON); Region: LON; smart00464 393011002213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393011002214 Walker A motif; other site 393011002215 ATP binding site [chemical binding]; other site 393011002216 Walker B motif; other site 393011002217 arginine finger; other site 393011002218 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 393011002219 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 393011002220 IHF dimer interface [polypeptide binding]; other site 393011002221 IHF - DNA interface [nucleotide binding]; other site 393011002222 SurA N-terminal domain; Region: SurA_N_3; cl07813 393011002223 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 393011002224 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 393011002225 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 393011002226 bacterial Hfq-like; Region: Hfq; cd01716 393011002227 hexamer interface [polypeptide binding]; other site 393011002228 Sm1 motif; other site 393011002229 RNA binding site [nucleotide binding]; other site 393011002230 Sm2 motif; other site 393011002231 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 393011002232 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 393011002233 HflX GTPase family; Region: HflX; cd01878 393011002234 G1 box; other site 393011002235 GTP/Mg2+ binding site [chemical binding]; other site 393011002236 Switch I region; other site 393011002237 G2 box; other site 393011002238 G3 box; other site 393011002239 Switch II region; other site 393011002240 G4 box; other site 393011002241 G5 box; other site 393011002242 pseudogene of monoxygenase 393011002243 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 393011002244 HflK protein; Region: hflK; TIGR01933 393011002245 FtsH protease regulator HflC; Provisional; Region: PRK11029 393011002246 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 393011002247 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 393011002248 Low molecular weight phosphatase family; Region: LMWPc; cd00115 393011002249 active site 393011002250 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 393011002251 G1 box; other site 393011002252 GTP/Mg2+ binding site [chemical binding]; other site 393011002253 Switch I region; other site 393011002254 G2 box; other site 393011002255 G3 box; other site 393011002256 Switch II region; other site 393011002257 G4 box; other site 393011002258 G5 box; other site 393011002259 pseudogene of threonine synthase 393011002260 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 393011002261 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 393011002262 pseudogene of dihydroxy-acid dehydratase 393011002263 acetolactate synthase; acetohydroxy acid synthetase 393011002264 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 393011002265 putative valine binding site [chemical binding]; other site 393011002266 dimer interface [polypeptide binding]; other site 393011002267 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 393011002268 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 393011002269 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 393011002270 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 393011002271 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 393011002272 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393011002273 ATP binding site [chemical binding]; other site 393011002274 putative Mg++ binding site [ion binding]; other site 393011002275 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393011002276 nucleotide binding region [chemical binding]; other site 393011002277 ATP-binding site [chemical binding]; other site 393011002278 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 393011002279 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 393011002280 YccA-like proteins; Region: YccA_like; cd10433 393011002281 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 393011002282 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 393011002283 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 393011002284 minor groove reading motif; other site 393011002285 helix-hairpin-helix signature motif; other site 393011002286 substrate binding pocket [chemical binding]; other site 393011002287 active site 393011002288 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 393011002289 ferredoxin; Provisional; Region: PRK08764 393011002290 Putative Fe-S cluster; Region: FeS; cl17515 393011002291 4Fe-4S binding domain; Region: Fer4; pfam00037 393011002292 glutaredoxin 2; Provisional; Region: PRK10387 393011002293 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 393011002294 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 393011002295 N-terminal domain interface [polypeptide binding]; other site 393011002296 pseudogene of POT family proton (H+)-dependent oligopeptide transporter 393011002297 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 393011002298 Ferritin-like domain; Region: Ferritin; pfam00210 393011002299 ferroxidase diiron center [ion binding]; other site 393011002300 lipoyl synthase; Provisional; Region: PRK05481 393011002301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393011002302 FeS/SAM binding site; other site 393011002303 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 393011002304 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 393011002305 conserved cys residue [active] 393011002306 hypothetical protein; Validated; Region: PRK00110 393011002307 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 393011002308 active site 393011002309 putative DNA-binding cleft [nucleotide binding]; other site 393011002310 dimer interface [polypeptide binding]; other site 393011002311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011002312 putative substrate translocation pore; other site 393011002313 D-galactonate transporter; Region: 2A0114; TIGR00893 393011002314 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 393011002315 RuvA N terminal domain; Region: RuvA_N; pfam01330 393011002316 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 393011002317 RmuC family; Region: RmuC; pfam02646 393011002318 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 393011002319 dimerization interface [polypeptide binding]; other site 393011002320 putative Zn2+ binding site [ion binding]; other site 393011002321 putative DNA binding site [nucleotide binding]; other site 393011002322 pseudogene of conserved hypothetical protein 393011002323 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 393011002324 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 393011002325 histidine decarboxylase; Provisional; Region: PRK02769 393011002326 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393011002327 catalytic residue [active] 393011002328 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 393011002329 intersubunit interface [polypeptide binding]; other site 393011002330 active site 393011002331 Zn2+ binding site [ion binding]; other site 393011002332 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 393011002333 active site 393011002334 DNA binding site [nucleotide binding] 393011002335 Isochorismatase family; Region: Isochorismatase; pfam00857 393011002336 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 393011002337 catalytic triad [active] 393011002338 conserved cis-peptide bond; other site 393011002339 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 393011002340 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 393011002341 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 393011002342 Mechanosensitive ion channel; Region: MS_channel; pfam00924 393011002343 pseudogene of MFS family major facilitator transporter 393011002344 pseudogene of MFS family major facilitator transporter 393011002345 pseudogene of possible deacylase 393011002346 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 393011002347 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 393011002348 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393011002349 active site 393011002350 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 393011002351 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 393011002352 5S rRNA interface [nucleotide binding]; other site 393011002353 CTC domain interface [polypeptide binding]; other site 393011002354 L16 interface [polypeptide binding]; other site 393011002355 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 393011002356 Domain of unknown function DUF21; Region: DUF21; pfam01595 393011002357 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 393011002358 Transporter associated domain; Region: CorC_HlyC; pfam03471 393011002359 pseudogene of probable methyltransferase 393011002360 pseudogene of iSSod13 transposase 393011002361 GTP-binding protein YchF; Reviewed; Region: PRK09601 393011002362 YchF GTPase; Region: YchF; cd01900 393011002363 G1 box; other site 393011002364 GTP/Mg2+ binding site [chemical binding]; other site 393011002365 Switch I region; other site 393011002366 G2 box; other site 393011002367 Switch II region; other site 393011002368 G3 box; other site 393011002369 G4 box; other site 393011002370 G5 box; other site 393011002371 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 393011002372 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 393011002373 putative active site [active] 393011002374 catalytic residue [active] 393011002375 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 393011002376 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 393011002377 dimerization domain [polypeptide binding]; other site 393011002378 dimer interface [polypeptide binding]; other site 393011002379 catalytic residues [active] 393011002380 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 393011002381 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 393011002382 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 393011002383 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 393011002384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393011002385 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 393011002386 pseudogene of possible VIC family voltage gated ion channel; possible potassium (K+) ion channel 393011002387 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 393011002388 POT family; Region: PTR2; cl17359 393011002389 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 393011002390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393011002391 Walker A motif; other site 393011002392 ATP binding site [chemical binding]; other site 393011002393 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 393011002394 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 393011002395 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 393011002396 active site 393011002397 HslU subunit interaction site [polypeptide binding]; other site 393011002398 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 393011002399 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 393011002400 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 393011002401 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 393011002402 active site 393011002403 HIGH motif; other site 393011002404 dimer interface [polypeptide binding]; other site 393011002405 KMSKS motif; other site 393011002406 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393011002407 RNA binding surface [nucleotide binding]; other site 393011002408 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011002409 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011002410 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011002411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011002412 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 393011002413 phosphate binding site [ion binding]; other site 393011002414 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 393011002415 FAD binding domain; Region: FAD_binding_4; pfam01565 393011002416 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 393011002417 pseudogene of Fe-S oxidoreductase 393011002418 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 393011002419 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 393011002420 dimer interface [polypeptide binding]; other site 393011002421 active site 393011002422 metal binding site [ion binding]; metal-binding site 393011002423 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 393011002424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393011002425 S-adenosylmethionine binding site [chemical binding]; other site 393011002426 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 393011002427 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 393011002428 FMN binding site [chemical binding]; other site 393011002429 active site 393011002430 catalytic residues [active] 393011002431 substrate binding site [chemical binding]; other site 393011002432 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 393011002433 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 393011002434 Methyltransferase domain; Region: Methyltransf_26; pfam13659 393011002435 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 393011002436 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 393011002437 putative active site [active] 393011002438 pseudogene of conserved hypothetical protein 393011002439 AAA domain; Region: AAA_21; pfam13304 393011002440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 393011002441 ABC transporter signature motif; other site 393011002442 Walker B; other site 393011002443 D-loop; other site 393011002444 H-loop/switch region; other site 393011002445 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 393011002446 active site 393011002447 DNA polymerase IV; Validated; Region: PRK02406 393011002448 DNA binding site [nucleotide binding] 393011002449 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 393011002450 DJ-1 family protein; Region: not_thiJ; TIGR01383 393011002451 conserved cys residue [active] 393011002452 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393011002453 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393011002454 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393011002455 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 393011002456 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 393011002457 GSH binding site [chemical binding]; other site 393011002458 catalytic residues [active] 393011002459 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 393011002460 dimer interface [polypeptide binding]; other site 393011002461 putative radical transfer pathway; other site 393011002462 diiron center [ion binding]; other site 393011002463 tyrosyl radical; other site 393011002464 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 393011002465 GSH binding site [chemical binding]; other site 393011002466 catalytic residues [active] 393011002467 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 393011002468 Class I ribonucleotide reductase; Region: RNR_I; cd01679 393011002469 active site 393011002470 dimer interface [polypeptide binding]; other site 393011002471 catalytic residues [active] 393011002472 effector binding site; other site 393011002473 R2 peptide binding site; other site 393011002474 malate dehydrogenase; Reviewed; Region: PRK06223 393011002475 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 393011002476 NAD(P) binding site [chemical binding]; other site 393011002477 dimer interface [polypeptide binding]; other site 393011002478 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393011002479 substrate binding site [chemical binding]; other site 393011002480 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 393011002481 diiron binding motif [ion binding]; other site 393011002482 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 393011002483 N-acetyl-D-glucosamine binding site [chemical binding]; other site 393011002484 catalytic residue [active] 393011002485 pseudogene of possible ThiF family protein 393011002486 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011002487 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011002488 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011002489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011002490 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 393011002491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393011002492 motif II; other site 393011002493 peroxidase; Provisional; Region: PRK15000 393011002494 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 393011002495 dimer interface [polypeptide binding]; other site 393011002496 decamer (pentamer of dimers) interface [polypeptide binding]; other site 393011002497 catalytic triad [active] 393011002498 peroxidatic and resolving cysteines [active] 393011002499 pseudogene of conserved hypothetical protein 393011002500 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 393011002501 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 393011002502 PhnA protein; Region: PhnA; pfam03831 393011002503 pseudogene of conserved hypothetical protein 393011002504 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 393011002505 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 393011002506 active site 393011002507 catalytic site [active] 393011002508 substrate binding site [chemical binding]; other site 393011002509 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 393011002510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 393011002511 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 393011002512 pseudogene of possible saccharopine dehydrogenase 393011002513 pseudogene of aldehyde dehydrogenase 393011002514 pseudogene of conserved hypothetical protein 393011002515 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 393011002516 putative homodimer interface [polypeptide binding]; other site 393011002517 putative homotetramer interface [polypeptide binding]; other site 393011002518 putative allosteric switch controlling residues; other site 393011002519 putative metal binding site [ion binding]; other site 393011002520 putative homodimer-homodimer interface [polypeptide binding]; other site 393011002521 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 393011002522 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 393011002523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393011002524 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 393011002525 dimerization interface [polypeptide binding]; other site 393011002526 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 393011002527 catalytic triad [active] 393011002528 dimer interface [polypeptide binding]; other site 393011002529 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 393011002530 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 393011002531 putative NAD(P) binding site [chemical binding]; other site 393011002532 homodimer interface [polypeptide binding]; other site 393011002533 cytidylate kinase; Provisional; Region: cmk; PRK00023 393011002534 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 393011002535 CMP-binding site; other site 393011002536 The sites determining sugar specificity; other site 393011002537 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 393011002538 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393011002539 catalytic residue [active] 393011002540 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011002541 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011002542 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011002543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011002544 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 393011002545 catalytic core [active] 393011002546 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 393011002547 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 393011002548 pseudogene of ISFtu2 transposase 393011002549 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 393011002550 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 393011002551 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 393011002552 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 393011002553 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 393011002554 replicative DNA helicase; Region: DnaB; TIGR00665 393011002555 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 393011002556 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 393011002557 Walker A motif; other site 393011002558 ATP binding site [chemical binding]; other site 393011002559 Walker B motif; other site 393011002560 DNA binding loops [nucleotide binding] 393011002561 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 393011002562 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393011002563 FeS/SAM binding site; other site 393011002564 Tetratricopeptide repeat; Region: TPR_12; pfam13424 393011002565 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 393011002566 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393011002567 RNA binding surface [nucleotide binding]; other site 393011002568 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 393011002569 probable active site [active] 393011002570 preprotein translocase subunit SecA; Validated; Region: secA; CHL00122 393011002571 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 393011002572 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 393011002573 Coenzyme A binding pocket [chemical binding]; other site 393011002574 pseudogene of ISFtu3 transposase 393011002575 sulfate adenylyltransferase; ATP-sulfurylase 393011002576 pseudogene of adenylylsulfate kinase 393011002577 PQ loop repeat; Region: PQ-loop; pfam04193 393011002578 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 393011002579 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 393011002580 substrate binding pocket [chemical binding]; other site 393011002581 chain length determination region; other site 393011002582 substrate-Mg2+ binding site; other site 393011002583 catalytic residues [active] 393011002584 aspartate-rich region 1; other site 393011002585 active site lid residues [active] 393011002586 aspartate-rich region 2; other site 393011002587 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 393011002588 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 393011002589 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 393011002590 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 393011002591 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 393011002592 Ligand Binding Site [chemical binding]; other site 393011002593 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 393011002594 active site 393011002595 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 393011002596 N-acetyl-D-glucosamine binding site [chemical binding]; other site 393011002597 catalytic residue [active] 393011002598 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 393011002599 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 393011002600 Yqey-like protein; Region: YqeY; pfam09424 393011002601 CHC2 zinc finger; Region: zf-CHC2; pfam01807 393011002602 DNA primase; Validated; Region: dnaG; PRK05667 393011002603 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 393011002604 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 393011002605 active site 393011002606 metal binding site [ion binding]; metal-binding site 393011002607 interdomain interaction site; other site 393011002608 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 393011002609 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 393011002610 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 393011002611 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 393011002612 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 393011002613 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 393011002614 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 393011002615 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 393011002616 DNA binding residues [nucleotide binding] 393011002617 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 393011002618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393011002619 pseudogene of probable glycosidase 393011002620 pseudogene of possible GPH family glycoside-pentoside-hexuronide:cation symporter 393011002621 lipoate-protein ligase B; Provisional; Region: PRK14342 393011002622 Protein of unknown function (DUF493); Region: DUF493; pfam04359 393011002623 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 393011002624 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 393011002625 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 393011002626 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 393011002627 dimer interface [polypeptide binding]; other site 393011002628 substrate binding site [chemical binding]; other site 393011002629 metal binding sites [ion binding]; metal-binding site 393011002630 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 393011002631 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393011002632 active site 393011002633 motif I; other site 393011002634 motif II; other site 393011002635 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 393011002636 OstA-like protein; Region: OstA; cl00844 393011002637 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 393011002638 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 393011002639 Walker A/P-loop; other site 393011002640 ATP binding site [chemical binding]; other site 393011002641 Q-loop/lid; other site 393011002642 ABC transporter signature motif; other site 393011002643 Walker B; other site 393011002644 D-loop; other site 393011002645 H-loop/switch region; other site 393011002646 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 393011002647 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 393011002648 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 393011002649 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 393011002650 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 393011002651 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 393011002652 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 393011002653 dimerization interface 3.5A [polypeptide binding]; other site 393011002654 active site 393011002655 pseudogene of APC family amino acid-polyamine-organocation transporter 393011002656 GMP synthase; Reviewed; Region: guaA; PRK00074 393011002657 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 393011002658 AMP/PPi binding site [chemical binding]; other site 393011002659 candidate oxyanion hole; other site 393011002660 catalytic triad [active] 393011002661 potential glutamine specificity residues [chemical binding]; other site 393011002662 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 393011002663 ATP Binding subdomain [chemical binding]; other site 393011002664 Ligand Binding sites [chemical binding]; other site 393011002665 Dimerization subdomain; other site 393011002666 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 393011002667 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 393011002668 TPP-binding site; other site 393011002669 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 393011002670 PYR/PP interface [polypeptide binding]; other site 393011002671 dimer interface [polypeptide binding]; other site 393011002672 TPP binding site [chemical binding]; other site 393011002673 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 393011002674 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 393011002675 putative active site pocket [active] 393011002676 dimerization interface [polypeptide binding]; other site 393011002677 putative catalytic residue [active] 393011002678 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 393011002679 active site 393011002680 catalytic triad [active] 393011002681 oxyanion hole [active] 393011002682 switch loop; other site 393011002683 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 393011002684 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 393011002685 classical (c) SDRs; Region: SDR_c; cd05233 393011002686 NAD(P) binding site [chemical binding]; other site 393011002687 active site 393011002688 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 393011002689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393011002690 Walker A motif; other site 393011002691 ATP binding site [chemical binding]; other site 393011002692 Walker B motif; other site 393011002693 arginine finger; other site 393011002694 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 393011002695 pseudogene of conserved hypothetical protein 393011002696 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 393011002697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393011002698 non-specific DNA binding site [nucleotide binding]; other site 393011002699 salt bridge; other site 393011002700 sequence-specific DNA binding site [nucleotide binding]; other site 393011002701 pseudogene of conserved hypothetical protein 393011002702 pseudogene of conserved hypothetical protein 393011002703 pseudogene of possible membrane transporter 393011002704 pseudogene of possible POT family proton (H+)-dependent oligopeptide transporter 393011002705 pseudogene of ISFtu2 transposase 393011002706 pseudogene of choloylglycine hydrolase 393011002707 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 393011002708 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 393011002709 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 393011002710 pseudogene of BCCT family betaine/carnitine/choline transporter 393011002711 TspO/MBR family; Region: TspO_MBR; pfam03073 393011002712 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 393011002713 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 393011002714 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 393011002715 pseudogene of MFS family major facilitator transporter 393011002716 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 393011002717 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 393011002718 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 393011002719 catalytic residues [active] 393011002720 pseudogene of macrophage infectivity potentiator 393011002721 pseudogene of probable iron-sulfur cluster-binding protein 393011002722 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 393011002723 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 393011002724 pseudogene of possible ATP-dependent DNA helicase II 393011002725 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 393011002726 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 393011002727 motif 1; other site 393011002728 active site 393011002729 motif 2; other site 393011002730 motif 3; other site 393011002731 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 393011002732 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 393011002733 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 393011002734 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 393011002735 interface (dimer of trimers) [polypeptide binding]; other site 393011002736 Substrate-binding/catalytic site; other site 393011002737 Zn-binding sites [ion binding]; other site 393011002738 transaldolase-like protein; Provisional; Region: PTZ00411 393011002739 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 393011002740 active site 393011002741 dimer interface [polypeptide binding]; other site 393011002742 catalytic residue [active] 393011002743 pseudogene of conserved hypothetical protein 393011002744 pseudogene of isochorismatase hydrolase 393011002745 pseudogene of ISFtu2 transposase 393011002746 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 393011002747 Isochorismatase family; Region: Isochorismatase; pfam00857 393011002748 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 393011002749 catalytic triad [active] 393011002750 conserved cis-peptide bond; other site 393011002751 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 393011002752 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 393011002753 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 393011002754 Part of AAA domain; Region: AAA_19; pfam13245 393011002755 Family description; Region: UvrD_C_2; pfam13538 393011002756 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 393011002757 S1 domain; Region: S1_2; pfam13509 393011002758 S1 domain; Region: S1_2; pfam13509 393011002759 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 393011002760 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 393011002761 active site residue [active] 393011002762 recombination associated protein; Reviewed; Region: rdgC; PRK00321 393011002763 pseudogene of conserved hypothetical protein 393011002764 HipA N-terminal domain; Region: couple_hipA; TIGR03071 393011002765 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 393011002766 HipA-like N-terminal domain; Region: HipA_N; pfam07805 393011002767 HipA-like C-terminal domain; Region: HipA_C; pfam07804 393011002768 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 393011002769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393011002770 non-specific DNA binding site [nucleotide binding]; other site 393011002771 salt bridge; other site 393011002772 sequence-specific DNA binding site [nucleotide binding]; other site 393011002773 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011002774 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011002775 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011002776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011002777 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 393011002778 pseudogene of probable rRNA methyltransferase 393011002779 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 393011002780 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 393011002781 active site 393011002782 dimerization interface [polypeptide binding]; other site 393011002783 Predicted membrane protein [Function unknown]; Region: COG2855 393011002784 putative transporter; Provisional; Region: PRK03699 393011002785 fragment of conserved hypothetical protein 393011002786 YCII-related domain; Region: YCII; cl00999 393011002787 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 393011002788 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 393011002789 dimer interface [polypeptide binding]; other site 393011002790 active site 393011002791 acyl carrier protein; Provisional; Region: acpP; PRK00982 393011002792 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 393011002793 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 393011002794 NAD(P) binding site [chemical binding]; other site 393011002795 homotetramer interface [polypeptide binding]; other site 393011002796 homodimer interface [polypeptide binding]; other site 393011002797 active site 393011002798 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 393011002799 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 393011002800 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 393011002801 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 393011002802 dimer interface [polypeptide binding]; other site 393011002803 active site 393011002804 CoA binding pocket [chemical binding]; other site 393011002805 putative phosphate acyltransferase; Provisional; Region: PRK05331 393011002806 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 393011002807 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 393011002808 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 393011002809 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 393011002810 TPP-binding site [chemical binding]; other site 393011002811 dimer interface [polypeptide binding]; other site 393011002812 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 393011002813 PYR/PP interface [polypeptide binding]; other site 393011002814 dimer interface [polypeptide binding]; other site 393011002815 TPP binding site [chemical binding]; other site 393011002816 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 393011002817 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 393011002818 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 393011002819 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 393011002820 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 393011002821 Phosphoglycerate kinase; Region: PGK; pfam00162 393011002822 substrate binding site [chemical binding]; other site 393011002823 hinge regions; other site 393011002824 ADP binding site [chemical binding]; other site 393011002825 catalytic site [active] 393011002826 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 393011002827 pyruvate kinase; Provisional; Region: PRK05826 393011002828 domain interfaces; other site 393011002829 active site 393011002830 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 393011002831 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 393011002832 intersubunit interface [polypeptide binding]; other site 393011002833 active site 393011002834 zinc binding site [ion binding]; other site 393011002835 Na+ binding site [ion binding]; other site 393011002836 alpha,alpha-trehalase; trehalase 393011002837 pseudogene of probable MFS family major facilitator superfamily transporter 393011002838 frameshift of ISFtu1 transposase 393011002839 pseudogene of conserved protein PdpD; PdpD1 393011002840 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 393011002841 Protein of unknown function (DUF877); Region: DUF877; pfam05943 393011002842 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 393011002843 Intracellular growth locus C protein; Region: IglC; pfam11550 393011002844 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 393011002845 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 393011002846 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 393011002847 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 393011002848 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 393011002849 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 393011002850 dimer interface [polypeptide binding]; other site 393011002851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393011002852 catalytic residue [active] 393011002853 choloylglycine hydrolase; bile salt hydrolase 393011002854 pseudogene of LysR family transcriptional regulator 393011002855 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 393011002856 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 393011002857 trmE is a tRNA modification GTPase; Region: trmE; cd04164 393011002858 G1 box; other site 393011002859 GTP/Mg2+ binding site [chemical binding]; other site 393011002860 Switch I region; other site 393011002861 G2 box; other site 393011002862 Switch II region; other site 393011002863 G3 box; other site 393011002864 G4 box; other site 393011002865 G5 box; other site 393011002866 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 393011002867 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 393011002868 30S subunit binding site; other site 393011002869 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393011002870 active site 393011002871 phosphorylation site [posttranslational modification] 393011002872 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 393011002873 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 393011002874 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 393011002875 RNA/DNA hybrid binding site [nucleotide binding]; other site 393011002876 active site 393011002877 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 393011002878 Na binding site [ion binding]; other site 393011002879 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 393011002880 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 393011002881 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 393011002882 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 393011002883 23S rRNA interface [nucleotide binding]; other site 393011002884 L3 interface [polypeptide binding]; other site 393011002885 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 393011002886 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 393011002887 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 393011002888 MltA specific insert domain; Region: MltA; smart00925 393011002889 3D domain; Region: 3D; pfam06725 393011002890 GrpE; Region: GrpE; pfam01025 393011002891 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 393011002892 dimer interface [polypeptide binding]; other site 393011002893 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 393011002894 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 393011002895 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 393011002896 nucleotide binding site [chemical binding]; other site 393011002897 chaperone protein DnaJ; Provisional; Region: PRK10767 393011002898 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 393011002899 HSP70 interaction site [polypeptide binding]; other site 393011002900 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 393011002901 substrate binding site [polypeptide binding]; other site 393011002902 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 393011002903 Zn binding sites [ion binding]; other site 393011002904 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 393011002905 dimer interface [polypeptide binding]; other site 393011002906 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393011002907 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 393011002908 putative effector binding pocket; other site 393011002909 dimerization interface [polypeptide binding]; other site 393011002910 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011002911 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011002912 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011002913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011002914 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 393011002915 EamA-like transporter family; Region: EamA; pfam00892 393011002916 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 393011002917 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 393011002918 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 393011002919 dimer interface [polypeptide binding]; other site 393011002920 motif 1; other site 393011002921 active site 393011002922 motif 2; other site 393011002923 motif 3; other site 393011002924 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 393011002925 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 393011002926 putative tRNA-binding site [nucleotide binding]; other site 393011002927 B3/4 domain; Region: B3_4; pfam03483 393011002928 tRNA synthetase B5 domain; Region: B5; smart00874 393011002929 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 393011002930 dimer interface [polypeptide binding]; other site 393011002931 motif 1; other site 393011002932 motif 3; other site 393011002933 motif 2; other site 393011002934 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 393011002935 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 393011002936 metal binding site 2 [ion binding]; metal-binding site 393011002937 putative DNA binding helix; other site 393011002938 metal binding site 1 [ion binding]; metal-binding site 393011002939 dimer interface [polypeptide binding]; other site 393011002940 structural Zn2+ binding site [ion binding]; other site 393011002941 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 393011002942 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 393011002943 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 393011002944 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 393011002945 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 393011002946 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 393011002947 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 393011002948 putative active site [active] 393011002949 catalytic site [active] 393011002950 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 393011002951 putative active site [active] 393011002952 catalytic site [active] 393011002953 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 393011002954 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 393011002955 putative active site [active] 393011002956 catalytic site [active] 393011002957 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 393011002958 putative active site [active] 393011002959 catalytic site [active] 393011002960 pseudogene of MFS family major facilitator transporter 393011002961 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 393011002962 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 393011002963 Walker A motif; other site 393011002964 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 393011002965 trimer interface [polypeptide binding]; other site 393011002966 active site 393011002967 pseudogene of MscS family small conductance mechanosenstive ion channel 393011002968 Lipopolysaccharide-assembly; Region: LptE; cl01125 393011002969 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 393011002970 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 393011002971 HIGH motif; other site 393011002972 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 393011002973 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 393011002974 active site 393011002975 KMSKS motif; other site 393011002976 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 393011002977 tRNA binding surface [nucleotide binding]; other site 393011002978 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 393011002979 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 393011002980 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 393011002981 Transglutaminase/protease-like homologues; Region: TGc; smart00460 393011002982 Sel1 repeat; Region: Sel1; cl02723 393011002983 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 393011002984 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 393011002985 pseudogene of mutator protein MutT 393011002986 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 393011002987 PAS fold; Region: PAS_4; pfam08448 393011002988 hypothetical protein; Provisional; Region: PRK07505 393011002989 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 393011002990 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393011002991 catalytic residue [active] 393011002992 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 393011002993 Transcriptional regulators [Transcription]; Region: MarR; COG1846 393011002994 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 393011002995 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 393011002996 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 393011002997 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 393011002998 catalytic residues [active] 393011002999 pseudogene of conserved hypothetical protein 393011003000 FeS assembly protein SufD; Region: sufD; TIGR01981 393011003001 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 393011003002 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 393011003003 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 393011003004 Walker A/P-loop; other site 393011003005 ATP binding site [chemical binding]; other site 393011003006 Q-loop/lid; other site 393011003007 ABC transporter signature motif; other site 393011003008 Walker B; other site 393011003009 D-loop; other site 393011003010 H-loop/switch region; other site 393011003011 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 393011003012 putative ABC transporter; Region: ycf24; CHL00085 393011003013 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 393011003014 Transcriptional regulator; Region: Rrf2; pfam02082 393011003015 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 393011003016 TrkA-N domain; Region: TrkA_N; pfam02254 393011003017 TrkA-N domain; Region: TrkA_N; pfam02254 393011003018 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 393011003019 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 393011003020 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 393011003021 rRNA binding site [nucleotide binding]; other site 393011003022 predicted 30S ribosome binding site; other site 393011003023 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 393011003024 signal recognition particle protein; Provisional; Region: PRK10867 393011003025 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 393011003026 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 393011003027 P loop; other site 393011003028 GTP binding site [chemical binding]; other site 393011003029 Signal peptide binding domain; Region: SRP_SPB; pfam02978 393011003030 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 393011003031 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 393011003032 pseudogene of conserved hypothetical protein 393011003033 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011003034 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011003035 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011003036 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011003037 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 393011003038 active site 393011003039 Zn binding site [ion binding]; other site 393011003040 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 393011003041 putative active site [active] 393011003042 putative catalytic site [active] 393011003043 putative DNA binding site [nucleotide binding]; other site 393011003044 putative phosphate binding site [ion binding]; other site 393011003045 metal binding site A [ion binding]; metal-binding site 393011003046 putative AP binding site [nucleotide binding]; other site 393011003047 putative metal binding site B [ion binding]; other site 393011003048 short chain dehydrogenase; Provisional; Region: PRK07577 393011003049 classical (c) SDRs; Region: SDR_c; cd05233 393011003050 NAD(P) binding site [chemical binding]; other site 393011003051 active site 393011003052 AAA domain; Region: AAA_17; pfam13207 393011003053 AAA domain; Region: AAA_18; pfam13238 393011003054 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 393011003055 glutathione reductase; Validated; Region: PRK06116 393011003056 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393011003057 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 393011003058 Uncharacterized conserved protein [Function unknown]; Region: COG0393 393011003059 pseudogene of ISFtu2 transposase 393011003060 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 393011003061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011003062 putative substrate translocation pore; other site 393011003063 POT family; Region: PTR2; cl17359 393011003064 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 393011003065 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 393011003066 ATP binding site [chemical binding]; other site 393011003067 Mg++ binding site [ion binding]; other site 393011003068 motif III; other site 393011003069 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393011003070 nucleotide binding region [chemical binding]; other site 393011003071 ATP-binding site [chemical binding]; other site 393011003072 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 393011003073 GTP cyclohydrolase I; Provisional; Region: PLN03044 393011003074 active site 393011003075 Uncharacterized conserved protein [Function unknown]; Region: COG1434 393011003076 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 393011003077 putative active site [active] 393011003078 pseudogene of conserved hypothetical protein 393011003079 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393011003080 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393011003081 active site 393011003082 catalytic tetrad [active] 393011003083 pseudogene of MFS family major facilitator transporter 393011003084 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 393011003085 Glutamine amidotransferase class-I; Region: GATase; pfam00117 393011003086 glutamine binding [chemical binding]; other site 393011003087 catalytic triad [active] 393011003088 aminodeoxychorismate synthase; Provisional; Region: PRK07508 393011003089 chorismate binding enzyme; Region: Chorismate_bind; cl10555 393011003090 Aminotransferase class IV; Region: Aminotran_4; pfam01063 393011003091 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 393011003092 substrate-cofactor binding pocket; other site 393011003093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393011003094 catalytic residue [active] 393011003095 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 393011003096 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 393011003097 acyl-activating enzyme (AAE) consensus motif; other site 393011003098 AMP binding site [chemical binding]; other site 393011003099 active site 393011003100 CoA binding site [chemical binding]; other site 393011003101 Dihydroneopterin aldolase; Region: FolB; smart00905 393011003102 active site 393011003103 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 393011003104 catalytic center binding site [active] 393011003105 ATP binding site [chemical binding]; other site 393011003106 dihydropteroate synthase; Region: DHPS; TIGR01496 393011003107 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 393011003108 substrate binding pocket [chemical binding]; other site 393011003109 dimer interface [polypeptide binding]; other site 393011003110 inhibitor binding site; inhibition site 393011003111 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 393011003112 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 393011003113 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 393011003114 adenosine deaminase; adenosine aminohydrolase 393011003115 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 393011003116 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 393011003117 inhibitor-cofactor binding pocket; inhibition site 393011003118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393011003119 catalytic residue [active] 393011003120 biotin synthase; Region: bioB; TIGR00433 393011003121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393011003122 FeS/SAM binding site; other site 393011003123 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 393011003124 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 393011003125 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 393011003126 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393011003127 catalytic residue [active] 393011003128 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 393011003129 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 393011003130 AAA domain; Region: AAA_26; pfam13500 393011003131 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393011003132 dimerization interface [polypeptide binding]; other site 393011003133 putative DNA binding site [nucleotide binding]; other site 393011003134 putative Zn2+ binding site [ion binding]; other site 393011003135 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 393011003136 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393011003137 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393011003138 nucleotide binding site [chemical binding]; other site 393011003139 pseudogene of MFS family major facilitator transporter 393011003140 acetoacetate decarboxylase; Provisional; Region: PRK02265 393011003141 3-hydroxybutyrate dehydrogenase; D-beta-hydroxybutyrate dehydrogenase 393011003142 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 393011003143 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 393011003144 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 393011003145 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 393011003146 inhibitor-cofactor binding pocket; inhibition site 393011003147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393011003148 catalytic residue [active] 393011003149 glutathione synthetase; Provisional; Region: PRK05246 393011003150 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 393011003151 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 393011003152 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 393011003153 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 393011003154 putative active site [active] 393011003155 substrate binding site [chemical binding]; other site 393011003156 putative cosubstrate binding site; other site 393011003157 catalytic site [active] 393011003158 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 393011003159 substrate binding site [chemical binding]; other site 393011003160 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 393011003161 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 393011003162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 393011003163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393011003164 S-adenosylmethionine binding site [chemical binding]; other site 393011003165 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 393011003166 conserved hypothetical protein fragment 393011003167 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 393011003168 active site 393011003169 nucleic acid binding site [nucleotide binding]; other site 393011003170 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011003171 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011003172 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011003173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011003174 pseudogene of conserved hypothetical protein 393011003175 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 393011003176 short chain dehydrogenase; Provisional; Region: PRK05993 393011003177 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 393011003178 NADP binding site [chemical binding]; other site 393011003179 active site 393011003180 steroid binding site; other site 393011003181 pseudogene of APC family amino acid-polyamine-organocation transporter 393011003182 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011003183 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011003184 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011003185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011003186 SnoaL-like domain; Region: SnoaL_2; pfam12680 393011003187 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 393011003188 pseudogene of ISFtu2 transposase 393011003189 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 393011003190 ferredoxin-NADP reductase; Provisional; Region: PRK10926 393011003191 FAD binding pocket [chemical binding]; other site 393011003192 FAD binding motif [chemical binding]; other site 393011003193 phosphate binding motif [ion binding]; other site 393011003194 beta-alpha-beta structure motif; other site 393011003195 NAD binding pocket [chemical binding]; other site 393011003196 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 393011003197 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 393011003198 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 393011003199 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 393011003200 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 393011003201 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 393011003202 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 393011003203 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 393011003204 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 393011003205 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 393011003206 active site 393011003207 multimer interface [polypeptide binding]; other site 393011003208 CTP synthetase; Validated; Region: pyrG; PRK05380 393011003209 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 393011003210 Catalytic site [active] 393011003211 active site 393011003212 UTP binding site [chemical binding]; other site 393011003213 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 393011003214 active site 393011003215 putative oxyanion hole; other site 393011003216 catalytic triad [active] 393011003217 pseudogene of possible S-transferase 393011003218 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011003219 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011003220 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011003221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011003222 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 393011003223 pseudogene of ISFtu2 transposase 393011003224 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 393011003225 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 393011003226 pseudogene of conserved hypothetical protein 393011003227 pseudogene of conserved hypothetical protein 393011003228 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 393011003229 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 393011003230 ligand binding site [chemical binding]; other site 393011003231 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 393011003232 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 393011003233 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 393011003234 active site 393011003235 (T/H)XGH motif; other site 393011003236 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 393011003237 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 393011003238 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 393011003239 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 393011003240 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393011003241 catalytic residue [active] 393011003242 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 393011003243 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 393011003244 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 393011003245 Protein of unknown function DUF45; Region: DUF45; pfam01863 393011003246 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 393011003247 Prephenate dehydratase; Region: PDT; pfam00800 393011003248 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 393011003249 putative L-Phe binding site [chemical binding]; other site 393011003250 pseudogene of APC family amino acid-polyamine-organocation transporter 393011003251 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 393011003252 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 393011003253 active site 393011003254 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 393011003255 dimer interface [polypeptide binding]; other site 393011003256 substrate binding site [chemical binding]; other site 393011003257 catalytic residues [active] 393011003258 pseudogene of possible POT family proton (H+)-dependent oligopeptide transporter 393011003259 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 393011003260 putative C-terminal domain interface [polypeptide binding]; other site 393011003261 putative GSH binding site [chemical binding]; other site 393011003262 putative dimer interface [polypeptide binding]; other site 393011003263 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 393011003264 dimer interface [polypeptide binding]; other site 393011003265 substrate binding pocket (H-site) [chemical binding]; other site 393011003266 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 393011003267 putative N-terminal domain interface [polypeptide binding]; other site 393011003268 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 393011003269 hypothetical protein; Provisional; Region: PRK14013 393011003270 pseudogene of conserved hypothetical protein 393011003271 pseudogene of ABC superfamily ATP binding cassette transporter, ABC protein 393011003272 pseudogene of conserved hypothetical protein 393011003273 pseudogene of ISFtu2 transposase 393011003274 pseudogene of ISFtu1 transposase 393011003275 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 393011003276 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 393011003277 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 393011003278 active site 393011003279 recombination protein F; Reviewed; Region: recF; PRK00064 393011003280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393011003281 Walker A/P-loop; other site 393011003282 ATP binding site [chemical binding]; other site 393011003283 Q-loop/lid; other site 393011003284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393011003285 ABC transporter signature motif; other site 393011003286 Walker B; other site 393011003287 D-loop; other site 393011003288 H-loop/switch region; other site 393011003289 pseudogene of conserved hypothetical protein 393011003290 EamA-like transporter family; Region: EamA; pfam00892 393011003291 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 393011003292 EamA-like transporter family; Region: EamA; pfam00892 393011003293 acetate--CoA ligase; acetate thiokinase 393011003294 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 393011003295 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 393011003296 active site 393011003297 tetramer interface; other site 393011003298 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 393011003299 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 393011003300 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 393011003301 pseudogene of conserved hypothetical protein 393011003302 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 393011003303 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 393011003304 DNA-binding site [nucleotide binding]; DNA binding site 393011003305 RNA-binding motif; other site 393011003306 Radical SAM superfamily; Region: Radical_SAM; pfam04055 393011003307 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393011003308 FeS/SAM binding site; other site 393011003309 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 393011003310 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 393011003311 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 393011003312 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 393011003313 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 393011003314 non-specific DNA interactions [nucleotide binding]; other site 393011003315 DNA binding site [nucleotide binding] 393011003316 sequence specific DNA binding site [nucleotide binding]; other site 393011003317 putative cAMP binding site [chemical binding]; other site 393011003318 Bacterial transcriptional regulator; Region: IclR; pfam01614 393011003319 pseudogene of conserved hypothetical protein 393011003320 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 393011003321 Fusaric acid resistance protein family; Region: FUSC; pfam04632 393011003322 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011003323 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011003324 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011003325 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011003326 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 393011003327 pseudogene of conserved hypothetical protein 393011003328 pseudogene of organic solvent tolerance protein 393011003329 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393011003330 RNA binding surface [nucleotide binding]; other site 393011003331 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 393011003332 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 393011003333 putative substrate binding site [chemical binding]; other site 393011003334 putative ATP binding site [chemical binding]; other site 393011003335 Putative serine esterase (DUF676); Region: DUF676; pfam05057 393011003336 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 393011003337 pseudogene of possible mandelate racemase/muconate lactonizing enzyme 393011003338 pseudogene of conserved hypothetical protein 393011003339 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 393011003340 catalytic residues [active] 393011003341 dimer interface [polypeptide binding]; other site 393011003342 Chorismate mutase type II; Region: CM_2; smart00830 393011003343 pseudogene of ISFtu2 transposase 393011003344 pseudogene of possible adenosine deaminase 393011003345 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 393011003346 L-aspartate oxidase; Provisional; Region: PRK06175 393011003347 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 393011003348 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 393011003349 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 393011003350 dimerization interface [polypeptide binding]; other site 393011003351 active site 393011003352 quinolinate synthetase; Provisional; Region: PRK09375 393011003353 Guanylate kinase; Region: Guanylate_kin; pfam00625 393011003354 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 393011003355 catalytic site [active] 393011003356 G-X2-G-X-G-K; other site 393011003357 helicase 45; Provisional; Region: PTZ00424 393011003358 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 393011003359 ATP binding site [chemical binding]; other site 393011003360 Mg++ binding site [ion binding]; other site 393011003361 motif III; other site 393011003362 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393011003363 nucleotide binding region [chemical binding]; other site 393011003364 ATP-binding site [chemical binding]; other site 393011003365 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 393011003366 putative RNA binding site [nucleotide binding]; other site 393011003367 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 393011003368 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 393011003369 pseudogene of MFS family major facilitator transporter; pseudogene of possible galactose-proton (H+)symporter 393011003370 pseudogene of MFS family major facilitator transporter; pseudogene of possible galactose-proton (H+)symporter 393011003371 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 393011003372 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 393011003373 dimer interface [polypeptide binding]; other site 393011003374 active site 393011003375 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 393011003376 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 393011003377 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 393011003378 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 393011003379 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 393011003380 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 393011003381 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 393011003382 Ligand binding site; other site 393011003383 oligomer interface; other site 393011003384 Uncharacterized conserved protein [Function unknown]; Region: COG2835 393011003385 pseudogene of conserved hypothetical protein 393011003386 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011003387 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011003388 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011003389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011003390 Uncharacterized conserved protein [Function unknown]; Region: COG0398 393011003391 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 393011003392 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 393011003393 23S rRNA binding site [nucleotide binding]; other site 393011003394 L21 binding site [polypeptide binding]; other site 393011003395 L13 binding site [polypeptide binding]; other site 393011003396 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 393011003397 translation initiation factor IF-3; Region: infC; TIGR00168 393011003398 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 393011003399 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 393011003400 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 393011003401 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 393011003402 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 393011003403 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 393011003404 active site 393011003405 dimer interface [polypeptide binding]; other site 393011003406 motif 1; other site 393011003407 motif 2; other site 393011003408 motif 3; other site 393011003409 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 393011003410 anticodon binding site; other site 393011003411 Chitin binding domain; Region: Chitin_bind_3; pfam03067 393011003412 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 393011003413 aromatic chitin/cellulose binding site residues [chemical binding]; other site 393011003414 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 393011003415 lipoyl attachment site [posttranslational modification]; other site 393011003416 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 393011003417 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 393011003418 homodimer interface [polypeptide binding]; other site 393011003419 active site 393011003420 hypothetical protein; Validated; Region: PRK00153 393011003421 recombination protein RecR; Provisional; Region: PRK13844 393011003422 RecR protein; Region: RecR; pfam02132 393011003423 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 393011003424 putative active site [active] 393011003425 putative metal-binding site [ion binding]; other site 393011003426 tetramer interface [polypeptide binding]; other site 393011003427 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 393011003428 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393011003429 Zn2+ binding site [ion binding]; other site 393011003430 Mg2+ binding site [ion binding]; other site 393011003431 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 393011003432 synthetase active site [active] 393011003433 NTP binding site [chemical binding]; other site 393011003434 metal binding site [ion binding]; metal-binding site 393011003435 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 393011003436 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 393011003437 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 393011003438 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 393011003439 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 393011003440 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393011003441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011003442 metabolite-proton symporter; Region: 2A0106; TIGR00883 393011003443 putative substrate translocation pore; other site 393011003444 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 393011003445 catalytic nucleophile [active] 393011003446 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 393011003447 proposed catalytic triad [active] 393011003448 active site nucleophile [active] 393011003449 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 393011003450 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 393011003451 substrate binding site [chemical binding]; other site 393011003452 ATP binding site [chemical binding]; other site 393011003453 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 393011003454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393011003455 motif II; other site 393011003456 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 393011003457 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 393011003458 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 393011003459 active site 393011003460 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 393011003461 active site 393011003462 LicD family; Region: LicD; pfam04991 393011003463 Methyltransferase domain; Region: Methyltransf_23; pfam13489 393011003464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393011003465 S-adenosylmethionine binding site [chemical binding]; other site 393011003466 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 393011003467 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 393011003468 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 393011003469 active site 393011003470 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393011003471 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393011003472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393011003473 Walker A/P-loop; other site 393011003474 ATP binding site [chemical binding]; other site 393011003475 Q-loop/lid; other site 393011003476 ABC transporter signature motif; other site 393011003477 Walker B; other site 393011003478 D-loop; other site 393011003479 H-loop/switch region; other site 393011003480 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 393011003481 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 393011003482 putative ADP-binding pocket [chemical binding]; other site 393011003483 UDP-glucose 4-epimerase; Region: PLN02240 393011003484 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 393011003485 NAD binding site [chemical binding]; other site 393011003486 homodimer interface [polypeptide binding]; other site 393011003487 active site 393011003488 substrate binding site [chemical binding]; other site 393011003489 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 393011003490 Bacterial sugar transferase; Region: Bac_transf; pfam02397 393011003491 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 393011003492 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 393011003493 substrate binding site [chemical binding]; other site 393011003494 hexamer interface [polypeptide binding]; other site 393011003495 metal binding site [ion binding]; metal-binding site 393011003496 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 393011003497 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 393011003498 putative active site [active] 393011003499 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 393011003500 DoxX; Region: DoxX; pfam07681 393011003501 pseudogene of conserved hypothetical protein 393011003502 pseudogene of conserved hypothetical protein 393011003503 arylsulfatase; aryl-sulfate sulphohydrolase 393011003504 pseudogene of ISFtu2 transposase 393011003505 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 393011003506 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 393011003507 NAD binding site [chemical binding]; other site 393011003508 homotetramer interface [polypeptide binding]; other site 393011003509 homodimer interface [polypeptide binding]; other site 393011003510 substrate binding site [chemical binding]; other site 393011003511 active site 393011003512 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 393011003513 pseudogene of ISFtu2 transposase 393011003514 pseudogene of ISFtu1 transposase 393011003515 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 393011003516 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 393011003517 GIY-YIG motif/motif A; other site 393011003518 active site 393011003519 catalytic site [active] 393011003520 putative DNA binding site [nucleotide binding]; other site 393011003521 metal binding site [ion binding]; metal-binding site 393011003522 UvrB/uvrC motif; Region: UVR; pfam02151 393011003523 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 393011003524 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 393011003525 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 393011003526 catalytic site [active] 393011003527 putative active site [active] 393011003528 putative substrate binding site [chemical binding]; other site 393011003529 HRDC domain; Region: HRDC; pfam00570 393011003530 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 393011003531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011003532 putative substrate translocation pore; other site 393011003533 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 393011003534 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 393011003535 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 393011003536 pseudogene of glycerate kinase 393011003537 DNA-3-methyladenine glycosylase I; DNA glycosidase I 393011003538 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 393011003539 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393011003540 ATP binding site [chemical binding]; other site 393011003541 putative Mg++ binding site [ion binding]; other site 393011003542 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 393011003543 SEC-C motif; Region: SEC-C; pfam02810 393011003544 LPP20 lipoprotein; Region: LPP20; cl15824 393011003545 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 393011003546 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011003547 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011003548 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011003549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011003550 pseudogene of ISFtu2 transposase 393011003551 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 393011003552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393011003553 Walker A motif; other site 393011003554 ATP binding site [chemical binding]; other site 393011003555 Walker B motif; other site 393011003556 arginine finger; other site 393011003557 Peptidase family M41; Region: Peptidase_M41; pfam01434 393011003558 pseudogene of MFS family major facilitator transporter 393011003559 pseudogene of ISFtu2 transposase 393011003560 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 393011003561 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 393011003562 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 393011003563 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 393011003564 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 393011003565 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 393011003566 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 393011003567 Type II transport protein GspH; Region: GspH; pfam12019 393011003568 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 393011003569 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 393011003570 active site 393011003571 dimer interface [polypeptide binding]; other site 393011003572 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 393011003573 dimer interface [polypeptide binding]; other site 393011003574 active site 393011003575 Thiamine pyrophosphokinase; Region: TPK; cd07995 393011003576 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 393011003577 active site 393011003578 dimerization interface [polypeptide binding]; other site 393011003579 thiamine binding site [chemical binding]; other site 393011003580 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 393011003581 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 393011003582 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 393011003583 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 393011003584 active site 393011003585 multifunctional aminopeptidase A; Provisional; Region: PRK00913 393011003586 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 393011003587 interface (dimer of trimers) [polypeptide binding]; other site 393011003588 Substrate-binding/catalytic site; other site 393011003589 Zn-binding sites [ion binding]; other site 393011003590 Predicted permeases [General function prediction only]; Region: COG0795 393011003591 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 393011003592 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 393011003593 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 393011003594 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 393011003595 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 393011003596 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 393011003597 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 393011003598 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 393011003599 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 393011003600 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 393011003601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 393011003602 Predicted membrane protein [Function unknown]; Region: COG2860 393011003603 UPF0126 domain; Region: UPF0126; pfam03458 393011003604 UPF0126 domain; Region: UPF0126; pfam03458 393011003605 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 393011003606 active site 393011003607 dinuclear metal binding site [ion binding]; other site 393011003608 dimerization interface [polypeptide binding]; other site 393011003609 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 393011003610 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 393011003611 active site 393011003612 catalytic motif [active] 393011003613 Zn binding site [ion binding]; other site 393011003614 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 393011003615 FAD binding domain; Region: FAD_binding_4; pfam01565 393011003616 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 393011003617 phosphoglyceromutase; Provisional; Region: PRK05434 393011003618 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 393011003619 seryl-tRNA synthetase; Provisional; Region: PRK05431 393011003620 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 393011003621 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 393011003622 dimer interface [polypeptide binding]; other site 393011003623 active site 393011003624 motif 1; other site 393011003625 motif 2; other site 393011003626 motif 3; other site 393011003627 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393011003628 ROK family; Region: ROK; pfam00480 393011003629 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 393011003630 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 393011003631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393011003632 Walker A/P-loop; other site 393011003633 ATP binding site [chemical binding]; other site 393011003634 Q-loop/lid; other site 393011003635 ABC transporter signature motif; other site 393011003636 Walker B; other site 393011003637 D-loop; other site 393011003638 H-loop/switch region; other site 393011003639 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 393011003640 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393011003641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393011003642 Walker A/P-loop; other site 393011003643 ATP binding site [chemical binding]; other site 393011003644 Q-loop/lid; other site 393011003645 ABC transporter signature motif; other site 393011003646 Walker B; other site 393011003647 D-loop; other site 393011003648 H-loop/switch region; other site 393011003649 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 393011003650 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 393011003651 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 393011003652 homotrimer interaction site [polypeptide binding]; other site 393011003653 putative active site [active] 393011003654 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 393011003655 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 393011003656 Sulfate transporter family; Region: Sulfate_transp; pfam00916 393011003657 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 393011003658 pseudogene of ISFtu2 transposase 393011003659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011003660 metabolite-proton symporter; Region: 2A0106; TIGR00883 393011003661 putative substrate translocation pore; other site 393011003662 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 393011003663 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393011003664 Zn2+ binding site [ion binding]; other site 393011003665 Mg2+ binding site [ion binding]; other site 393011003666 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 393011003667 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 393011003668 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 393011003669 heme binding site [chemical binding]; other site 393011003670 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 393011003671 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011003672 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011003673 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011003674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011003675 pseudogene of oxidoreductase; short-chain dehydrogenase/reductase 393011003676 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 393011003677 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 393011003678 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 393011003679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011003680 putative substrate translocation pore; other site 393011003681 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 393011003682 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 393011003683 active site 393011003684 catalytic site [active] 393011003685 metal binding site [ion binding]; metal-binding site 393011003686 pseudogene of conserved hypothetical protein 393011003687 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393011003688 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393011003689 Walker A/P-loop; other site 393011003690 ATP binding site [chemical binding]; other site 393011003691 Q-loop/lid; other site 393011003692 ABC transporter signature motif; other site 393011003693 Walker B; other site 393011003694 D-loop; other site 393011003695 H-loop/switch region; other site 393011003696 pseudogene of ABC superfamily ATP binding cassette transporter, membrane protein 393011003697 pseudogene of ISFtu2 transposase 393011003698 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 393011003699 putative substrate binding pocket [chemical binding]; other site 393011003700 trimer interface [polypeptide binding]; other site 393011003701 formyltetrahydrofolate deformylase; formyl-FH(4) hydrolase 393011003702 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393011003703 active site 393011003704 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 393011003705 Glyco_18 domain; Region: Glyco_18; smart00636 393011003706 active site 393011003707 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 393011003708 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 393011003709 aromatic chitin/cellulose binding site residues [chemical binding]; other site 393011003710 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 393011003711 aromatic chitin/cellulose binding site residues [chemical binding]; other site 393011003712 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 393011003713 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 393011003714 substrate-cofactor binding pocket; other site 393011003715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393011003716 catalytic residue [active] 393011003717 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 393011003718 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 393011003719 NAD(P) binding site [chemical binding]; other site 393011003720 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 393011003721 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 393011003722 substrate binding site; other site 393011003723 dimer interface; other site 393011003724 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 393011003725 Septum formation initiator; Region: DivIC; cl17659 393011003726 enolase; Provisional; Region: eno; PRK00077 393011003727 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 393011003728 dimer interface [polypeptide binding]; other site 393011003729 metal binding site [ion binding]; metal-binding site 393011003730 substrate binding pocket [chemical binding]; other site 393011003731 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393011003732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011003733 putative substrate translocation pore; other site 393011003734 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 393011003735 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; pfam00370 393011003736 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393011003737 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 393011003738 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 393011003739 TRAM domain; Region: TRAM; pfam01938 393011003740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393011003741 S-adenosylmethionine binding site [chemical binding]; other site 393011003742 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 393011003743 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 393011003744 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 393011003745 ATP-binding site [chemical binding]; other site 393011003746 Sugar specificity; other site 393011003747 Pyrimidine base specificity; other site 393011003748 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 393011003749 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 393011003750 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 393011003751 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 393011003752 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 393011003753 oligomer interface [polypeptide binding]; other site 393011003754 RNA binding site [nucleotide binding]; other site 393011003755 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 393011003756 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 393011003757 RNase E interface [polypeptide binding]; other site 393011003758 trimer interface [polypeptide binding]; other site 393011003759 active site 393011003760 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 393011003761 putative nucleic acid binding region [nucleotide binding]; other site 393011003762 G-X-X-G motif; other site 393011003763 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 393011003764 RNA binding site [nucleotide binding]; other site 393011003765 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 393011003766 16S/18S rRNA binding site [nucleotide binding]; other site 393011003767 S13e-L30e interaction site [polypeptide binding]; other site 393011003768 25S rRNA binding site [nucleotide binding]; other site 393011003769 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 393011003770 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 393011003771 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 393011003772 Cell division protein FtsL; Region: FtsL; cl11433 393011003773 MraW methylase family; Region: Methyltransf_5; cl17771 393011003774 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 393011003775 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 393011003776 AMP-binding enzyme; Region: AMP-binding; pfam00501 393011003777 acyl-activating enzyme (AAE) consensus motif; other site 393011003778 putative AMP binding site [chemical binding]; other site 393011003779 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 393011003780 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 393011003781 DNA binding site [nucleotide binding] 393011003782 catalytic residue [active] 393011003783 H2TH interface [polypeptide binding]; other site 393011003784 putative catalytic residues [active] 393011003785 turnover-facilitating residue; other site 393011003786 intercalation triad [nucleotide binding]; other site 393011003787 8OG recognition residue [nucleotide binding]; other site 393011003788 putative reading head residues; other site 393011003789 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 393011003790 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 393011003791 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011003792 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011003793 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011003794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011003795 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 393011003796 predicted active site [active] 393011003797 catalytic triad [active] 393011003798 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 393011003799 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 393011003800 active site 393011003801 multimer interface [polypeptide binding]; other site 393011003802 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 393011003803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393011003804 ATP binding site [chemical binding]; other site 393011003805 Mg2+ binding site [ion binding]; other site 393011003806 G-X-G motif; other site 393011003807 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 393011003808 anchoring element; other site 393011003809 dimer interface [polypeptide binding]; other site 393011003810 ATP binding site [chemical binding]; other site 393011003811 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 393011003812 active site 393011003813 putative metal-binding site [ion binding]; other site 393011003814 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 393011003815 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 393011003816 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 393011003817 FMN binding site [chemical binding]; other site 393011003818 active site 393011003819 catalytic residues [active] 393011003820 substrate binding site [chemical binding]; other site 393011003821 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 393011003822 TIGR03546 family protein; Region: TIGR03546 393011003823 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 393011003824 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 393011003825 CoA-ligase; Region: Ligase_CoA; pfam00549 393011003826 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 393011003827 CoA binding domain; Region: CoA_binding; smart00881 393011003828 CoA-ligase; Region: Ligase_CoA; pfam00549 393011003829 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 393011003830 hypothetical protein; Provisional; Region: PRK07206 393011003831 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 393011003832 pseudogene of possible POT family proton (H+)-dependent oligopeptide transporter 393011003833 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 393011003834 active site 393011003835 dimer interface [polypeptide binding]; other site 393011003836 catalytic nucleophile [active] 393011003837 pseudogene of conserved hypothetical protein 393011003838 pseudogene of conserved hypothetical protein 393011003839 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 393011003840 MFS transport protein AraJ; Provisional; Region: PRK10091 393011003841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011003842 putative substrate translocation pore; other site 393011003843 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393011003844 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393011003845 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 393011003846 putative effector binding pocket; other site 393011003847 dimerization interface [polypeptide binding]; other site 393011003848 phosphoglycolate phosphatase; Provisional; Region: PRK13222 393011003849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393011003850 motif II; other site 393011003851 pseudogene of phospholipase D 393011003852 thioredoxin reductase; Provisional; Region: PRK10262 393011003853 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393011003854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393011003855 pseudogene of ISFtu2 transposase 393011003856 pseudogene of MFS family major facilitator transporter 393011003857 pseudogene of possible macrolide efflux protein 393011003858 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 393011003859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393011003860 ATP binding site [chemical binding]; other site 393011003861 Mg2+ binding site [ion binding]; other site 393011003862 G-X-G motif; other site 393011003863 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 393011003864 ATP binding site [chemical binding]; other site 393011003865 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 393011003866 pseudogene of conserved hypothetical protein 393011003867 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 393011003868 Predicted GTPases [General function prediction only]; Region: COG1162 393011003869 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 393011003870 RNA binding site [nucleotide binding]; other site 393011003871 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 393011003872 GTPase/Zn-binding domain interface [polypeptide binding]; other site 393011003873 GTP/Mg2+ binding site [chemical binding]; other site 393011003874 G4 box; other site 393011003875 G5 box; other site 393011003876 G1 box; other site 393011003877 Switch I region; other site 393011003878 G2 box; other site 393011003879 G3 box; other site 393011003880 Switch II region; other site 393011003881 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 393011003882 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 393011003883 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 393011003884 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 393011003885 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 393011003886 Domain of unknown function DUF20; Region: UPF0118; pfam01594 393011003887 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 393011003888 DHH family; Region: DHH; pfam01368 393011003889 DHHA1 domain; Region: DHHA1; pfam02272 393011003890 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 393011003891 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 393011003892 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 393011003893 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 393011003894 motif 1; other site 393011003895 dimer interface [polypeptide binding]; other site 393011003896 active site 393011003897 motif 2; other site 393011003898 motif 3; other site 393011003899 pseudogene of possible MscS family small conductance mechanosenstive ion channel 393011003900 pseudogene of ISFtu2 transposase 393011003901 Helix-turn-helix domain; Region: HTH_25; pfam13413 393011003902 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 393011003903 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 393011003904 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 393011003905 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 393011003906 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 393011003907 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 393011003908 carboxyltransferase (CT) interaction site; other site 393011003909 biotinylation site [posttranslational modification]; other site 393011003910 Dehydroquinase class II; Region: DHquinase_II; pfam01220 393011003911 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 393011003912 trimer interface [polypeptide binding]; other site 393011003913 active site 393011003914 dimer interface [polypeptide binding]; other site 393011003915 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 393011003916 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 393011003917 active site 393011003918 metal binding site [ion binding]; metal-binding site 393011003919 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 393011003920 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 393011003921 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 393011003922 SurA N-terminal domain; Region: SurA_N; pfam09312 393011003923 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 393011003924 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 393011003925 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 393011003926 Organic solvent tolerance protein; Region: OstA_C; pfam04453 393011003927 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 393011003928 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 393011003929 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 393011003930 active site 393011003931 HIGH motif; other site 393011003932 nucleotide binding site [chemical binding]; other site 393011003933 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 393011003934 KMSK motif region; other site 393011003935 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 393011003936 tRNA binding surface [nucleotide binding]; other site 393011003937 anticodon binding site; other site 393011003938 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 393011003939 active site 393011003940 homodimer interface [polypeptide binding]; other site 393011003941 homotetramer interface [polypeptide binding]; other site 393011003942 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 393011003943 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 393011003944 dimer interface [polypeptide binding]; other site 393011003945 active site 393011003946 Schiff base residues; other site 393011003947 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 393011003948 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 393011003949 DNA polymerase III subunit delta'; Validated; Region: PRK08485 393011003950 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 393011003951 putative inner membrane peptidase; Provisional; Region: PRK11778 393011003952 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 393011003953 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 393011003954 tandem repeat interface [polypeptide binding]; other site 393011003955 oligomer interface [polypeptide binding]; other site 393011003956 active site residues [active] 393011003957 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 393011003958 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 393011003959 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 393011003960 dimer interface [polypeptide binding]; other site 393011003961 N-terminal domain interface [polypeptide binding]; other site 393011003962 DsrC like protein; Region: DsrC; pfam04358 393011003963 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 393011003964 oxidative damage protection protein; Provisional; Region: PRK05408 393011003965 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 393011003966 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 393011003967 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011003968 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011003969 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011003970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011003971 fragment of conserved hypothetical protein 393011003972 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 393011003973 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 393011003974 Ligand binding site; other site 393011003975 Putative Catalytic site; other site 393011003976 DXD motif; other site 393011003977 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 393011003978 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 393011003979 putative active site [active] 393011003980 YdjC motif; other site 393011003981 Mg binding site [ion binding]; other site 393011003982 putative homodimer interface [polypeptide binding]; other site 393011003983 cell division protein FtsW; Region: ftsW; TIGR02614 393011003984 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 393011003985 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393011003986 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 393011003987 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 393011003988 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 393011003989 Mg++ binding site [ion binding]; other site 393011003990 putative catalytic motif [active] 393011003991 putative substrate binding site [chemical binding]; other site 393011003992 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 393011003993 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 393011003994 active site 393011003995 metal-binding site [ion binding] 393011003996 nucleotide-binding site [chemical binding]; other site 393011003997 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 393011003998 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 393011003999 active site 393011004000 HIGH motif; other site 393011004001 nucleotide binding site [chemical binding]; other site 393011004002 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 393011004003 KMSKS motif; other site 393011004004 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 393011004005 pseudogene of conserved hypothetical protein 393011004006 pseudogene of POT family proton (H+)-dependent oligopeptide transporter 393011004007 ABC transporter ATPase component; Reviewed; Region: PRK11147 393011004008 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393011004009 Walker A/P-loop; other site 393011004010 ATP binding site [chemical binding]; other site 393011004011 Q-loop/lid; other site 393011004012 ABC transporter signature motif; other site 393011004013 Walker B; other site 393011004014 D-loop; other site 393011004015 H-loop/switch region; other site 393011004016 ABC transporter; Region: ABC_tran_2; pfam12848 393011004017 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393011004018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004019 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393011004020 putative substrate translocation pore; other site 393011004021 Predicted membrane protein [Function unknown]; Region: COG4129 393011004022 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 393011004023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004024 putative substrate translocation pore; other site 393011004025 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 393011004026 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 393011004027 rRNA methylase fragment 393011004028 fragment of conserved hypothetical protein 393011004029 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011004030 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011004031 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011004032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011004033 pseudogene of conserved hypothetical protein 393011004034 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393011004035 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393011004036 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 393011004037 dimerization interface [polypeptide binding]; other site 393011004038 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 393011004039 aromatic chitin/cellulose binding site residues [chemical binding]; other site 393011004040 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 393011004041 aromatic chitin/cellulose binding site residues [chemical binding]; other site 393011004042 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 393011004043 active site 393011004044 pseudogene of lipoprotein 393011004045 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 393011004046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393011004047 S-adenosylmethionine binding site [chemical binding]; other site 393011004048 pseudogene of APC family amino acid-polyamine-organocation membrane protein 393011004049 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 393011004050 pseudogene of ISFtu1 transposase; ISFtu1 393011004051 glycerol kinase; Provisional; Region: glpK; PRK00047 393011004052 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 393011004053 N- and C-terminal domain interface [polypeptide binding]; other site 393011004054 active site 393011004055 MgATP binding site [chemical binding]; other site 393011004056 catalytic site [active] 393011004057 metal binding site [ion binding]; metal-binding site 393011004058 glycerol binding site [chemical binding]; other site 393011004059 homotetramer interface [polypeptide binding]; other site 393011004060 homodimer interface [polypeptide binding]; other site 393011004061 FBP binding site [chemical binding]; other site 393011004062 protein IIAGlc interface [polypeptide binding]; other site 393011004063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004064 putative substrate translocation pore; other site 393011004065 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393011004066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393011004068 putative substrate translocation pore; other site 393011004069 pseudogene of (oligopeptide) ABC superfamily ATP binding cassette transporter, ABC protein 393011004070 pseudogene of (oligopeptide) ABC superfamily ATP binding cassette transporter, membrane protein 393011004071 pseudogene of (oligopeptide) ABC superfamily ATP binding cassette transporter, membrane protein 393011004072 pseudogene of (oligopeptide) ABC superfamily ATP binding cassette transporter, binding protein 393011004073 pseudogene of ISFtu2 transposase 393011004074 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 393011004075 Part of AAA domain; Region: AAA_19; pfam13245 393011004076 Family description; Region: UvrD_C_2; pfam13538 393011004077 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 393011004078 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 393011004079 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 393011004080 GTP binding site [chemical binding]; other site 393011004081 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393011004082 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 393011004083 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 393011004084 G1 box; other site 393011004085 putative GEF interaction site [polypeptide binding]; other site 393011004086 GTP/Mg2+ binding site [chemical binding]; other site 393011004087 Switch I region; other site 393011004088 G2 box; other site 393011004089 G3 box; other site 393011004090 Switch II region; other site 393011004091 G4 box; other site 393011004092 G5 box; other site 393011004093 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 393011004094 thymidylate kinase; Validated; Region: tmk; PRK00698 393011004095 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 393011004096 TMP-binding site; other site 393011004097 ATP-binding site [chemical binding]; other site 393011004098 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 393011004099 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 393011004100 Nucleoside recognition; Region: Gate; pfam07670 393011004101 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 393011004102 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 393011004103 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 393011004104 Nucleoside recognition; Region: Gate; pfam07670 393011004105 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 393011004106 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 393011004107 intersubunit interface [polypeptide binding]; other site 393011004108 active site 393011004109 catalytic residue [active] 393011004110 phosphopentomutase; Provisional; Region: PRK05362 393011004111 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 393011004112 pantothenate kinase; Reviewed; Region: PRK13324 393011004113 DNA polymerase I; Provisional; Region: PRK05755 393011004114 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 393011004115 active site 393011004116 metal binding site 1 [ion binding]; metal-binding site 393011004117 putative 5' ssDNA interaction site; other site 393011004118 metal binding site 3; metal-binding site 393011004119 metal binding site 2 [ion binding]; metal-binding site 393011004120 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 393011004121 putative DNA binding site [nucleotide binding]; other site 393011004122 putative metal binding site [ion binding]; other site 393011004123 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 393011004124 active site 393011004125 catalytic site [active] 393011004126 substrate binding site [chemical binding]; other site 393011004127 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 393011004128 active site 393011004129 DNA binding site [nucleotide binding] 393011004130 catalytic site [active] 393011004131 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 393011004132 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 393011004133 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 393011004134 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393011004135 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 393011004136 Walker A/P-loop; other site 393011004137 ATP binding site [chemical binding]; other site 393011004138 Q-loop/lid; other site 393011004139 ABC transporter signature motif; other site 393011004140 Walker B; other site 393011004141 D-loop; other site 393011004142 H-loop/switch region; other site 393011004143 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 393011004144 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 393011004145 active site 393011004146 NTP binding site [chemical binding]; other site 393011004147 metal binding triad [ion binding]; metal-binding site 393011004148 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 393011004149 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 393011004150 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 393011004151 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 393011004152 HlyD family secretion protein; Region: HlyD_3; pfam13437 393011004153 multidrug efflux protein; Reviewed; Region: PRK09579 393011004154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004155 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 393011004156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004157 pseudogene of ISFtu4 transposase 393011004158 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 393011004159 dimer interface [polypeptide binding]; other site 393011004160 catalytic triad [active] 393011004161 pseudogene of ISFtu3 transposase 393011004162 pseudogene of ISFtu2 transposase 393011004163 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011004164 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011004165 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011004166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011004167 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 393011004168 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 393011004169 active site 393011004170 HIGH motif; other site 393011004171 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 393011004172 KMSKS motif; other site 393011004173 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 393011004174 tRNA binding surface [nucleotide binding]; other site 393011004175 anticodon binding site; other site 393011004176 HemK family putative methylases; Region: hemK_fam; TIGR00536 393011004177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393011004178 S-adenosylmethionine binding site [chemical binding]; other site 393011004179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004180 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393011004181 putative substrate translocation pore; other site 393011004182 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 393011004183 Coenzyme A binding pocket [chemical binding]; other site 393011004184 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011004185 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011004186 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011004187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011004188 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 393011004189 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 393011004190 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 393011004191 pseudogene of metal ion transporter 393011004192 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 393011004193 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 393011004194 DXD motif; other site 393011004195 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 393011004196 Na binding site [ion binding]; other site 393011004197 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 393011004198 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 393011004199 putative active site [active] 393011004200 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 393011004201 lysine transporter; Provisional; Region: PRK10836 393011004202 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 393011004203 active site 393011004204 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 393011004205 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 393011004206 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 393011004207 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 393011004208 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 393011004209 Cation transport protein; Region: TrkH; cl17365 393011004210 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 393011004211 pseudogene of activator of ProP osmoprotectant transporter 393011004212 pseudogene of a type I site-specific restriction-modification system, R 393011004213 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011004214 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011004215 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011004216 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011004217 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 393011004218 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 393011004219 ring oligomerisation interface [polypeptide binding]; other site 393011004220 ATP/Mg binding site [chemical binding]; other site 393011004221 stacking interactions; other site 393011004222 hinge regions; other site 393011004223 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 393011004224 oligomerisation interface [polypeptide binding]; other site 393011004225 mobile loop; other site 393011004226 roof hairpin; other site 393011004227 Predicted membrane protein [Function unknown]; Region: COG4125 393011004228 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 393011004229 hypothetical protein; Validated; Region: PRK02101 393011004230 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011004231 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011004232 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011004233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011004234 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 393011004235 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 393011004236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393011004237 peptide chain release factor 1; Validated; Region: prfA; PRK00591 393011004238 This domain is found in peptide chain release factors; Region: PCRF; smart00937 393011004239 RF-1 domain; Region: RF-1; pfam00472 393011004240 glutamyl-tRNA reductase; Provisional; Region: PRK13940 393011004241 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 393011004242 tRNA; other site 393011004243 putative tRNA binding site [nucleotide binding]; other site 393011004244 putative NADP binding site [chemical binding]; other site 393011004245 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 393011004246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393011004247 TPR motif; other site 393011004248 binding surface 393011004249 Tetratricopeptide repeat; Region: TPR_16; pfam13432 393011004250 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 393011004251 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 393011004252 Trp docking motif [polypeptide binding]; other site 393011004253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004254 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 393011004255 putative substrate translocation pore; other site 393011004256 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 393011004257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393011004258 Mg2+ binding site [ion binding]; other site 393011004259 G-X-G motif; other site 393011004260 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 393011004261 anchoring element; other site 393011004262 dimer interface [polypeptide binding]; other site 393011004263 ATP binding site [chemical binding]; other site 393011004264 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 393011004265 active site 393011004266 metal binding site [ion binding]; metal-binding site 393011004267 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 393011004268 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 393011004269 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 393011004270 amidase catalytic site [active] 393011004271 Zn binding residues [ion binding]; other site 393011004272 substrate binding site [chemical binding]; other site 393011004273 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 393011004274 active site 393011004275 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 393011004276 putative active site [active] 393011004277 Ap4A binding site [chemical binding]; other site 393011004278 nudix motif; other site 393011004279 putative metal binding site [ion binding]; other site 393011004280 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 393011004281 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 393011004282 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 393011004283 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 393011004284 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 393011004285 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 393011004286 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 393011004287 active site 393011004288 DNA binding site [nucleotide binding] 393011004289 Int/Topo IB signature motif; other site 393011004290 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 393011004291 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 393011004292 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 393011004293 RimM N-terminal domain; Region: RimM; pfam01782 393011004294 PRC-barrel domain; Region: PRC; pfam05239 393011004295 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 393011004296 S-adenosylmethionine synthetase; Validated; Region: PRK05250 393011004297 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 393011004298 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 393011004299 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 393011004300 Fatty acid desaturase; Region: FA_desaturase; pfam00487 393011004301 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 393011004302 Di-iron ligands [ion binding]; other site 393011004303 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 393011004304 UGMP family protein; Validated; Region: PRK09604 393011004305 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 393011004306 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 393011004307 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 393011004308 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 393011004309 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 393011004310 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 393011004311 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 393011004312 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 393011004313 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 393011004314 cleft; other site 393011004315 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 393011004316 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 393011004317 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 393011004318 DNA binding site [nucleotide binding] 393011004319 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 393011004320 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 393011004321 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 393011004322 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 393011004323 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 393011004324 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 393011004325 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 393011004326 RPB3 interaction site [polypeptide binding]; other site 393011004327 RPB1 interaction site [polypeptide binding]; other site 393011004328 RPB11 interaction site [polypeptide binding]; other site 393011004329 RPB10 interaction site [polypeptide binding]; other site 393011004330 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 393011004331 core dimer interface [polypeptide binding]; other site 393011004332 peripheral dimer interface [polypeptide binding]; other site 393011004333 L10 interface [polypeptide binding]; other site 393011004334 L11 interface [polypeptide binding]; other site 393011004335 putative EF-Tu interaction site [polypeptide binding]; other site 393011004336 putative EF-G interaction site [polypeptide binding]; other site 393011004337 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 393011004338 23S rRNA interface [nucleotide binding]; other site 393011004339 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 393011004340 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 393011004341 mRNA/rRNA interface [nucleotide binding]; other site 393011004342 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 393011004343 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 393011004344 23S rRNA interface [nucleotide binding]; other site 393011004345 L7/L12 interface [polypeptide binding]; other site 393011004346 putative thiostrepton binding site; other site 393011004347 L25 interface [polypeptide binding]; other site 393011004348 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 393011004349 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 393011004350 putative homodimer interface [polypeptide binding]; other site 393011004351 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 393011004352 heterodimer interface [polypeptide binding]; other site 393011004353 homodimer interface [polypeptide binding]; other site 393011004354 pseudogene of preprotein translocase SecE subunit 393011004355 elongation factor Tu; Reviewed; Region: PRK00049 393011004356 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 393011004357 G1 box; other site 393011004358 GEF interaction site [polypeptide binding]; other site 393011004359 GTP/Mg2+ binding site [chemical binding]; other site 393011004360 Switch I region; other site 393011004361 G2 box; other site 393011004362 G3 box; other site 393011004363 Switch II region; other site 393011004364 G4 box; other site 393011004365 G5 box; other site 393011004366 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 393011004367 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 393011004368 Antibiotic Binding Site [chemical binding]; other site 393011004369 pseudogene of helicase 393011004370 Mechanosensitive ion channel; Region: MS_channel; pfam00924 393011004371 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 393011004372 amphipathic channel; other site 393011004373 Asn-Pro-Ala signature motifs; other site 393011004374 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 393011004375 pseudogene of ISFtu1 transposase 393011004376 pseudogene of conserved hypothetical protein 393011004377 ATP-grasp domain; Region: ATP-grasp_4; cl17255 393011004378 pseudogene of conserved hypothetical protein 393011004379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 393011004380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393011004381 dimer interface [polypeptide binding]; other site 393011004382 phosphorylation site [posttranslational modification] 393011004383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393011004384 ATP binding site [chemical binding]; other site 393011004385 Mg2+ binding site [ion binding]; other site 393011004386 G-X-G motif; other site 393011004387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 393011004388 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 393011004389 NAD(P) binding site [chemical binding]; other site 393011004390 active site 393011004391 pseudogene of cytochrome d ubiquinol oxidase subunit I 393011004392 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 393011004393 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 393011004394 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 393011004395 pseudogene of oxidoreductase 393011004396 pseduogene of Type IV pilus nucleotide-binding protein 393011004397 aconitate hydratase; Validated; Region: PRK09277 393011004398 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 393011004399 substrate binding site [chemical binding]; other site 393011004400 ligand binding site [chemical binding]; other site 393011004401 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 393011004402 substrate binding site [chemical binding]; other site 393011004403 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 393011004404 Predicted membrane protein [Function unknown]; Region: COG2246 393011004405 GtrA-like protein; Region: GtrA; pfam04138 393011004406 HemN family oxidoreductase; Provisional; Region: PRK05660 393011004407 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393011004408 FeS/SAM binding site; other site 393011004409 HemN C-terminal domain; Region: HemN_C; pfam06969 393011004410 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 393011004411 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 393011004412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393011004413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393011004414 Preprotein translocase SecG subunit; Region: SecG; pfam03840 393011004415 triosephosphate isomerase; Provisional; Region: PRK14567 393011004416 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 393011004417 substrate binding site [chemical binding]; other site 393011004418 dimer interface [polypeptide binding]; other site 393011004419 catalytic triad [active] 393011004420 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 393011004421 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 393011004422 active site 393011004423 substrate binding site [chemical binding]; other site 393011004424 metal binding site [ion binding]; metal-binding site 393011004425 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393011004426 active site 393011004427 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 393011004428 E3 interaction surface; other site 393011004429 lipoyl attachment site [posttranslational modification]; other site 393011004430 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 393011004431 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 393011004432 E3 interaction surface; other site 393011004433 lipoyl attachment site [posttranslational modification]; other site 393011004434 e3 binding domain; Region: E3_binding; pfam02817 393011004435 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 393011004436 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 393011004437 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 393011004438 TPP-binding site [chemical binding]; other site 393011004439 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 393011004440 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 393011004441 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 393011004442 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 393011004443 L-aspartate oxidase; Provisional; Region: PRK06175 393011004444 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 393011004445 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 393011004446 SdhC subunit interface [polypeptide binding]; other site 393011004447 proximal heme binding site [chemical binding]; other site 393011004448 cardiolipin binding site; other site 393011004449 Iron-sulfur protein interface; other site 393011004450 proximal quinone binding site [chemical binding]; other site 393011004451 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 393011004452 Iron-sulfur protein interface; other site 393011004453 proximal quinone binding site [chemical binding]; other site 393011004454 SdhD (CybS) interface [polypeptide binding]; other site 393011004455 proximal heme binding site [chemical binding]; other site 393011004456 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 393011004457 dimer interface [polypeptide binding]; other site 393011004458 Citrate synthase; Region: Citrate_synt; pfam00285 393011004459 active site 393011004460 citrylCoA binding site [chemical binding]; other site 393011004461 NADH binding [chemical binding]; other site 393011004462 cationic pore residues; other site 393011004463 oxalacetate/citrate binding site [chemical binding]; other site 393011004464 coenzyme A binding site [chemical binding]; other site 393011004465 catalytic triad [active] 393011004466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004467 muropeptide transporter; Reviewed; Region: ampG; PRK11902 393011004468 putative substrate translocation pore; other site 393011004469 superoxide dismutase; Provisional; Region: PRK10543 393011004470 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 393011004471 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 393011004472 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 393011004473 putative GSH binding site [chemical binding]; other site 393011004474 catalytic residues [active] 393011004475 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 393011004476 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 393011004477 putative active site [active] 393011004478 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 393011004479 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 393011004480 gamma subunit interface [polypeptide binding]; other site 393011004481 epsilon subunit interface [polypeptide binding]; other site 393011004482 LBP interface [polypeptide binding]; other site 393011004483 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 393011004484 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 393011004485 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 393011004486 alpha subunit interaction interface [polypeptide binding]; other site 393011004487 Walker A motif; other site 393011004488 ATP binding site [chemical binding]; other site 393011004489 Walker B motif; other site 393011004490 inhibitor binding site; inhibition site 393011004491 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 393011004492 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 393011004493 core domain interface [polypeptide binding]; other site 393011004494 delta subunit interface [polypeptide binding]; other site 393011004495 epsilon subunit interface [polypeptide binding]; other site 393011004496 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 393011004497 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 393011004498 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 393011004499 beta subunit interaction interface [polypeptide binding]; other site 393011004500 Walker A motif; other site 393011004501 ATP binding site [chemical binding]; other site 393011004502 Walker B motif; other site 393011004503 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 393011004504 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 393011004505 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 393011004506 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 393011004507 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 393011004508 F0F1 ATP synthase subunit C; Provisional; Region: PRK13464 393011004509 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 393011004510 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 393011004511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393011004512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004513 putative substrate translocation pore; other site 393011004514 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 393011004515 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393011004516 RNA binding surface [nucleotide binding]; other site 393011004517 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 393011004518 active site 393011004519 Predicted ATPase [General function prediction only]; Region: COG1485 393011004520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004521 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 393011004522 putative substrate translocation pore; other site 393011004523 histidyl-tRNA synthetase; Region: hisS; TIGR00442 393011004524 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 393011004525 dimer interface [polypeptide binding]; other site 393011004526 motif 1; other site 393011004527 active site 393011004528 motif 2; other site 393011004529 motif 3; other site 393011004530 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 393011004531 anticodon binding site; other site 393011004532 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 393011004533 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 393011004534 translation initiation factor IF-2; Region: IF-2; TIGR00487 393011004535 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 393011004536 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 393011004537 G1 box; other site 393011004538 putative GEF interaction site [polypeptide binding]; other site 393011004539 GTP/Mg2+ binding site [chemical binding]; other site 393011004540 Switch I region; other site 393011004541 G2 box; other site 393011004542 G3 box; other site 393011004543 Switch II region; other site 393011004544 G4 box; other site 393011004545 G5 box; other site 393011004546 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 393011004547 Translation-initiation factor 2; Region: IF-2; pfam11987 393011004548 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 393011004549 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 393011004550 NusA N-terminal domain; Region: NusA_N; pfam08529 393011004551 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 393011004552 RNA binding site [nucleotide binding]; other site 393011004553 homodimer interface [polypeptide binding]; other site 393011004554 NusA-like KH domain; Region: KH_5; pfam13184 393011004555 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 393011004556 G-X-X-G motif; other site 393011004557 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 393011004558 ribosome maturation protein RimP; Reviewed; Region: PRK00092 393011004559 hypothetical protein; Provisional; Region: PRK14641 393011004560 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 393011004561 putative oligomer interface [polypeptide binding]; other site 393011004562 putative RNA binding site [nucleotide binding]; other site 393011004563 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 393011004564 substrate binding site [chemical binding]; other site 393011004565 active site 393011004566 pseudogene of probable competence protein ComM 393011004567 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011004568 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011004569 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011004570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011004571 Membrane fusogenic activity; Region: BMFP; pfam04380 393011004572 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 393011004573 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 393011004574 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 393011004575 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 393011004576 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 393011004577 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 393011004578 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 393011004579 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 393011004580 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 393011004581 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 393011004582 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 393011004583 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 393011004584 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 393011004585 NADH dehydrogenase subunit G; Validated; Region: PRK09129 393011004586 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 393011004587 catalytic loop [active] 393011004588 iron binding site [ion binding]; other site 393011004589 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 393011004590 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 393011004591 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 393011004592 SLBB domain; Region: SLBB; pfam10531 393011004593 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 393011004594 NADH dehydrogenase subunit E; Validated; Region: PRK07539 393011004595 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 393011004596 putative dimer interface [polypeptide binding]; other site 393011004597 [2Fe-2S] cluster binding site [ion binding]; other site 393011004598 NADH dehydrogenase subunit D; Validated; Region: PRK06075 393011004599 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 393011004600 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 393011004601 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 393011004602 NADH dehydrogenase subunit B; Validated; Region: PRK06411 393011004603 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 393011004604 ferric uptake regulator; Provisional; Region: fur; PRK09462 393011004605 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 393011004606 metal binding site 2 [ion binding]; metal-binding site 393011004607 putative DNA binding helix; other site 393011004608 metal binding site 1 [ion binding]; metal-binding site 393011004609 dimer interface [polypeptide binding]; other site 393011004610 structural Zn2+ binding site [ion binding]; other site 393011004611 IucA / IucC family; Region: IucA_IucC; pfam04183 393011004612 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 393011004613 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393011004614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004615 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 393011004616 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 393011004617 dimer interface [polypeptide binding]; other site 393011004618 active site 393011004619 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 393011004620 catalytic residues [active] 393011004621 substrate binding site [chemical binding]; other site 393011004622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004623 putative substrate translocation pore; other site 393011004624 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 393011004625 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 393011004626 active site 393011004627 oxyanion hole [active] 393011004628 catalytic triad [active] 393011004629 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 393011004630 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 393011004631 GatB domain; Region: GatB_Yqey; smart00845 393011004632 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 393011004633 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 393011004634 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 393011004635 pseudogene of probable efflux membrane fusion protein 393011004636 pseudogene of conserved hypothetical protein 393011004637 adenylosuccinate lyase; Provisional; Region: PRK07492 393011004638 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 393011004639 tetramer interface [polypeptide binding]; other site 393011004640 active site 393011004641 pseudogene of ISFtu2 transposase 393011004642 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 393011004643 active site 393011004644 catalytic residues [active] 393011004645 pseudogene of restriction endonuclease 393011004646 pseudogene of possible DNA modification methyltransferase 393011004647 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 393011004648 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 393011004649 dimerization interface [polypeptide binding]; other site 393011004650 ATP binding site [chemical binding]; other site 393011004651 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 393011004652 dimerization interface [polypeptide binding]; other site 393011004653 ATP binding site [chemical binding]; other site 393011004654 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 393011004655 putative active site [active] 393011004656 catalytic triad [active] 393011004657 amidophosphoribosyltransferase; Provisional; Region: PRK09246 393011004658 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 393011004659 active site 393011004660 tetramer interface [polypeptide binding]; other site 393011004661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393011004662 active site 393011004663 pseudogene of glutamate decarboxylase 393011004664 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 393011004665 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 393011004666 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 393011004667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 393011004668 putative protease; Provisional; Region: PRK15452 393011004669 Peptidase family U32; Region: Peptidase_U32; pfam01136 393011004670 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 393011004671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004672 putative substrate translocation pore; other site 393011004673 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 393011004674 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 393011004675 pseudogene of ABC superfamily ATP binding cassette transporter, binding protein 393011004676 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 393011004677 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 393011004678 GTP1/OBG; Region: GTP1_OBG; pfam01018 393011004679 Obg GTPase; Region: Obg; cd01898 393011004680 G1 box; other site 393011004681 GTP/Mg2+ binding site [chemical binding]; other site 393011004682 Switch I region; other site 393011004683 G2 box; other site 393011004684 G3 box; other site 393011004685 Switch II region; other site 393011004686 G4 box; other site 393011004687 G5 box; other site 393011004688 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 393011004689 aromatic amino acid transport protein; Region: araaP; TIGR00837 393011004690 pseudogene of outer membrane associated protein 393011004691 pseudogene of probable transcriptional regulatory protein KdpE 393011004692 pseudogene of two component sensor protein KdpD 393011004693 K+-transporting ATPase, c chain; Region: KdpC; cl00944 393011004694 potassium-transporting ATPase; K(+)-importing ATPase 393011004695 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 393011004696 pseudogene of possible NAD-dependent formate dehydrogenase 393011004697 pseudogene of ISFtu2 transposase 393011004698 pseudogene of ISFtu1 transposase 393011004699 pseudogene of 3-isopropylmalate dehydrogenase 393011004700 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 393011004701 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 393011004702 substrate binding site [chemical binding]; other site 393011004703 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 393011004704 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 393011004705 substrate binding site [chemical binding]; other site 393011004706 ligand binding site [chemical binding]; other site 393011004707 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011004708 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011004709 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011004710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011004711 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 393011004712 pseudogene of ISFtu2 transposase 393011004713 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 393011004714 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 393011004715 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 393011004716 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 393011004717 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 393011004718 glutamine synthetase; Region: PLN02284 393011004719 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 393011004720 Eps15 homology domain; Region: EH; smart00027 393011004721 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 393011004722 Glutaminase; Region: Glutaminase; cl00907 393011004723 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 393011004724 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 393011004725 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 393011004726 pseudogene of conserved hypothetical protein 393011004727 hypothetical protein; Provisional; Region: PRK05208 393011004728 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 393011004729 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 393011004730 dimer interface [polypeptide binding]; other site 393011004731 putative anticodon binding site; other site 393011004732 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 393011004733 motif 1; other site 393011004734 active site 393011004735 motif 2; other site 393011004736 motif 3; other site 393011004737 This domain is found in peptide chain release factors; Region: PCRF; smart00937 393011004738 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 393011004739 RF-1 domain; Region: RF-1; pfam00472 393011004740 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 393011004741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393011004742 Walker A motif; other site 393011004743 ATP binding site [chemical binding]; other site 393011004744 Walker B motif; other site 393011004745 DNA polymerase III subunit delta'; Validated; Region: PRK08485 393011004746 arginine finger; other site 393011004747 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 393011004748 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 393011004749 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 393011004750 cell division protein FtsZ; Validated; Region: PRK09330 393011004751 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 393011004752 nucleotide binding site [chemical binding]; other site 393011004753 SulA interaction site; other site 393011004754 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 393011004755 Cell division protein FtsA; Region: FtsA; smart00842 393011004756 Cell division protein FtsA; Region: FtsA; pfam14450 393011004757 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 393011004758 Cell division protein FtsQ; Region: FtsQ; pfam03799 393011004759 D-alanyl-alanine synthetase A; Provisional; Region: PRK14569 393011004760 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 393011004761 ATP-grasp domain; Region: ATP-grasp_4; cl17255 393011004762 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 393011004763 nucleoside/Zn binding site; other site 393011004764 dimer interface [polypeptide binding]; other site 393011004765 catalytic motif [active] 393011004766 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 393011004767 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 393011004768 RNA binding site [nucleotide binding]; other site 393011004769 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 393011004770 RNA binding site [nucleotide binding]; other site 393011004771 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 393011004772 RNA binding site [nucleotide binding]; other site 393011004773 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 393011004774 RNA binding site [nucleotide binding]; other site 393011004775 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 393011004776 RNA binding site [nucleotide binding]; other site 393011004777 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 393011004778 RNA binding site [nucleotide binding]; other site 393011004779 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 393011004780 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 393011004781 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 393011004782 putative acyl-acceptor binding pocket; other site 393011004783 pseudogene of possible competence protein ComA 393011004784 pseudogene of glutathione synthase/ribosomal protein S6 modification protein 393011004785 pseudogene of ABC superfamily ATP binding cassette transporter, membrane protein 393011004786 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393011004787 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 393011004788 Walker A/P-loop; other site 393011004789 ATP binding site [chemical binding]; other site 393011004790 Q-loop/lid; other site 393011004791 ABC transporter signature motif; other site 393011004792 Walker B; other site 393011004793 D-loop; other site 393011004794 H-loop/switch region; other site 393011004795 YGGT family; Region: YGGT; pfam02325 393011004796 YGGT family; Region: YGGT; pfam02325 393011004797 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 393011004798 putative active site [active] 393011004799 Zn binding site [ion binding]; other site 393011004800 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011004801 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011004802 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011004803 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011004804 pseudogene of transposase ISFtu2 393011004805 pseudogene of possible HAAAP family transport protein 393011004806 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 393011004807 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 393011004808 purine monophosphate binding site [chemical binding]; other site 393011004809 dimer interface [polypeptide binding]; other site 393011004810 putative catalytic residues [active] 393011004811 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 393011004812 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 393011004813 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 393011004814 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 393011004815 GDP-binding site [chemical binding]; other site 393011004816 ACT binding site; other site 393011004817 IMP binding site; other site 393011004818 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393011004819 active site 393011004820 pseudogene of possible dienelactone hydrolase family protein 393011004821 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 393011004822 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393011004823 dimer interface [polypeptide binding]; other site 393011004824 putative PBP binding regions; other site 393011004825 ABC-ATPase subunit interface; other site 393011004826 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 393011004827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393011004828 Walker A/P-loop; other site 393011004829 ATP binding site [chemical binding]; other site 393011004830 Q-loop/lid; other site 393011004831 ABC transporter signature motif; other site 393011004832 Walker B; other site 393011004833 D-loop; other site 393011004834 H-loop/switch region; other site 393011004835 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 393011004836 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 393011004837 intersubunit interface [polypeptide binding]; other site 393011004838 pseudogene of MFS family major facilitator transporter 393011004839 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 393011004840 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 393011004841 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 393011004842 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 393011004843 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 393011004844 primosome assembly protein PriA; Validated; Region: PRK05580 393011004845 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393011004846 ATP binding site [chemical binding]; other site 393011004847 putative Mg++ binding site [ion binding]; other site 393011004848 helicase superfamily c-terminal domain; Region: HELICc; smart00490 393011004849 Transposase; Region: HTH_Tnp_IS630; pfam01710 393011004850 Helix-turn-helix domain; Region: HTH_28; pfam13518 393011004851 DDE superfamily endonuclease; Region: DDE_3; pfam13358 393011004852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 393011004853 pseudogene of conserved hypothetical protein 393011004854 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 393011004855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393011004856 Walker A/P-loop; other site 393011004857 ATP binding site [chemical binding]; other site 393011004858 Q-loop/lid; other site 393011004859 ABC transporter signature motif; other site 393011004860 Walker B; other site 393011004861 D-loop; other site 393011004862 H-loop/switch region; other site 393011004863 ABC transporter; Region: ABC_tran_2; pfam12848 393011004864 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393011004865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393011004866 metabolite-proton symporter; Region: 2A0106; TIGR00883 393011004867 putative substrate translocation pore; other site 393011004868 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 393011004869 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 393011004870 pseudogene of LysE family L-lysine exporter 393011004871 pseudogene of possible chromosomal replication initiation inhibitor 393011004872 pseudogene of conserved hypothetical protein 393011004873 pseudogene of ISFtu3 transposase 393011004874 aminopeptidase N; Provisional; Region: pepN; PRK14015 393011004875 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 393011004876 active site 393011004877 Zn binding site [ion binding]; other site 393011004878 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 393011004879 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 393011004880 putative dimer interface [polypeptide binding]; other site 393011004881 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 393011004882 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 393011004883 active site 393011004884 ribulose/triose binding site [chemical binding]; other site 393011004885 phosphate binding site [ion binding]; other site 393011004886 substrate (anthranilate) binding pocket [chemical binding]; other site 393011004887 product (indole) binding pocket [chemical binding]; other site 393011004888 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 393011004889 active site 393011004890 pseudogene of conserved hypothetical protein 393011004891 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 393011004892 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 393011004893 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 393011004894 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 393011004895 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 393011004896 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 393011004897 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 393011004898 Glutamine amidotransferase class-I; Region: GATase; pfam00117 393011004899 glutamine binding [chemical binding]; other site 393011004900 catalytic triad [active] 393011004901 anthranilate synthase component I; Provisional; Region: PRK13564 393011004902 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 393011004903 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 393011004904 Trp repressor protein; Region: Trp_repressor; cl17266 393011004905 ribonuclease G; Provisional; Region: PRK11712 393011004906 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 393011004907 homodimer interface [polypeptide binding]; other site 393011004908 oligonucleotide binding site [chemical binding]; other site